All posts by student

Queen’s University Belfast Vice-Chancellor Patrick Johnston dies suddenly – Belfast Telegraph

Queen's University Belfast Vice-Chancellor Patrick Johnston dies suddenly

BelfastTelegraph.co.uk

Queen's University Belfast's Vice-Chancellor Patrick Johnston has died suddenly.

http://www.belfasttelegraph.co.uk/news/northern-ireland/queens-university-belfast-vicechancellor-patrick-johnston-dies-suddenly-35787432.html

http://www.belfasttelegraph.co.uk/news/northern-ireland/article35787511.ece/af72b/AUTOCROP/h342/2016-09-19_new_24750948_I1.JPG

Queen's University Belfast's Vice-Chancellor Patrick Johnston has died suddenly.

The news of his death came in an email to staff from the university's registrar, James O'Kane on Sunday afternoon.

Professor Johnston's cause of death has not yet been revealed. Queen's University has said more information will be made available.

Obituary: Prof Patrick Johnston - a great mind whose work saved lives

In a statement the Queen's University said: "It is, with a deep sense of shock and loss, that I have to announce the untimely and sudden death of our Vice-Chancellor, Professor Patrick Johnston, earlier today.

"We extend our deepest sympathies and condolences to Iseult, his wife, and their four boys, Seamus, Eoghan, Niall and Ruairi, and the wider family circle at this desperately sad time.

"We will provide further updates in due course."

QUB academic and green party councillor John Barry said the news would come as a shock to staff at the Russell group university.

He said: "He was our first locally based Vice-Chancellor in quite some time - and was extremely youthful and energetic. It's a complete shock."

His loss will be felt not just at home here in Northern Ireland but right around the world where he was hugely respected. DUP leader Arlene Foster

The SDLP's Dr Alasdair McDonnell paid tribute to the "powerful figure" and said he was deeply saddened by news of Professor Johnston's death.

He said: "I am deeply saddened to hear the news of the untimely death of Professor Paddy Johnston. His death is a terrible loss to Queens University, cancer research and Northern Ireland.

Professor Johnston was a powerful figure, working to find a cure for cancer. One of his greatest achievements is undoubtedly leading the establishment of the Centre for Cancer Research and Cell Biology in Belfast.

I express my deepest sympathies and condolences to his family and QUB colleagues at this difficult time.

UUP MLA Alan Chambers said: "Many will remember Patrick particularly for his work in leading the establishment of the Centre for Cancer Research and Cell Biology.

"For his tireless work in this field we are indebted to him."

His loss will be keenly felt also by all those who admired his determination to find a cure for cancer and who respected his decision to return to Belfast to lead the Centre for Cancer Research. Sinn Fein MLA Mairtin O Muilleoir

Professor Johnston from Londonderry was the first person to be appointed President and Vice-Chancellor from within the staff of Queens since the appointment of Sir Peter Froggatt in 1976.

Professor Johnston was regarded as one of the world's leading cancer researchers.

He joined Queens University in 1996 as Professor of Oncology, later leading the establishment of the Centre for Cancer Research and Cell Biology.

Since then CCRCB has revolutionised cancer treatment in Northern Ireland and further afield. It now has 250 researchers from all over the world and was designated a Cancer Research UK Centre in 2009.

Until taking up the post of President and Vice-Chancellor of Queens in March 2014, Professor Johnston was Dean of the School of Medicine, Dentistry and Biomedical Sciences where he led the foundation of a new international Medical School and Institute of Health Sciences.

His own research focus over 25 years has been on the understanding of mechanisms of drug resistance to therapeutic agents.

This resulted in a number of prestigious landmark publications, more than 20 patents and the award of grants of 95m from research and philanthropic bodies including Cancer Research UK, the Medical Research Council, Atlantic Philanthropies, the Department of Health, Social Services and Public Safety and the National Institute of Health.

In 2012 he received a Diamond Jubilee Queens Anniversary Prize from Her Majesty The Queen for the University-led reorganisation of cancer care in Northern Ireland.

Belfast Telegraph Digital

More:
Queen's University Belfast Vice-Chancellor Patrick Johnston dies suddenly - Belfast Telegraph

How I Aced Biochemistry – PreMedLife – The Lifestyle Magazine for Pre-Medical Students

College hallways abound with rumors on the blood, sweat, and tears that accompany biochemistry. Mechanisms, pathways, enzymes Anxiety crept upon me after I signed up for the class and anticipated syllabus day until I stood up, determined, that I willsucceed biochemistry! I understand the heavy workload, tediousness, and specificity of the material, so I would like to share a handful tips on how I aced the class!

When we hear judgments, we could feasibly become influenced by their opinions and prejudge our experiences before we even set foot. I eventually decided to block out peoples opinions on the class, and focus on making the course my own experience. It is crucial to realize other peoples experiences do not determine yours. Further, avoid assuming the nature of the class. It may be boring, and on top of that, nearly impossible! I just hate memorizing pathways! Your attitude affects your performance. Perhaps, approach with a more open viewpoint of the class: It might be challenging, but Im open to learning about the underlying machinery of the human body. If you already find biochemistry intriguing, you are ahead of step one!

Some professors provide students with lecture notes online to print, as others do not. If your professor does not, recording the lecture could help tremendously to go back and listen to what you may have missed or to gain a more solid understanding. If the professor does provide online lecture notes, make sure to print them or download them onto your computer. I read over the lecture notes the same day of the class and quizzed myself over simple questions on the material on the notes. (Keep in mind: biochemistry includes application, critical thinking, and memorization, so your exam most likely may ask questions on a deeper level, but understanding the basics of the lecture is the point of quizzing yourself over the lecture notes). I divided the notes into sections and turned the stated lecture notes into questions to ask and quiz myself over. With this step, you will be familiar with what was covered in class.

A helpful way to perform on exams is to ask the professor if the lecture notes or textbook serve more as a basis for the exams. I studied lecture notes and read the textbook, regardless of when my professor stated the lecture notes were sufficient for the tests (reading the textbook chapters helped tremendously with the exams!) Not everybody prefers to read textbooks, or even needs the textbook for high performance, so this step depends on personal preference. As the material can be overwhelming, I divided my reading into paragraphs. I would read one paragraph once, read it again and highlight, then write my notes in my own words. Be sure to take breaks too!

You cannot go wrong with getting to know your professor! They could introduce you to resources that can help you, take time to elaborate concepts, and overall, help you along your academic journey. If you do not understand material, be sure to make time to visit your professors office hours with a list of things to ask. Emailing is a great option as well (if your professor checks it!); however, face-to-face interaction facilitates the ability to ask questions.

I am such a visual learner! It can be hard for me to visualize the chymotrypsin mechanism or the way translation works. Looking up these mechanisms on YouTube eased understanding of these concepts because I obtained a visual grasp on how they work.

My professor provided us with practice exams for the class; however, if your professor does not, worry not! I sometimes chose not to go with the exams the professor offered and googled biochemistry practice exams for a particular set of topics. It obviously will most likely not resemble your exams difficulty, application style, etc., but it will help train you to apply your knowledge, rather than soak up everything you have learned without using it. Be sure to practice those math problems too!

I have disappointed myself a few times throughout the class, and overall, my college experience. It happens! We are human. Breathe. What matters is your attitude, which drives the recovery. If you did not get the grade you expected, contact the professor, let him/her aware of your concern and what you can do to perform better next time, go over the exam, go over practice problems, etc. At the end of the day, you are taking a challenging class and are willing to succeed! Give yourself credit for the amazing effort you are putting in! Believe in yourself!

Originally posted here:
How I Aced Biochemistry - PreMedLife - The Lifestyle Magazine for Pre-Medical Students

Anatomy of two at-bats: Roberto Osuna overrules Aaron Judge in Blue Jays’ victories – The Athletic (Toronto) (subscription)

Anatomy of two at-bats: Roberto Osuna overrules Aaron Judge in Blue Jays victories

Join the community of the most die-hard Toronto sports fans, players, and executives who subscribe. The best writers. Unique content. No ads, no fluff.

Already a User?

Original post:
Anatomy of two at-bats: Roberto Osuna overrules Aaron Judge in Blue Jays' victories - The Athletic (Toronto) (subscription)

What does neuroscience have to do with family business? – grbj.com

One mid-November night, I was driving down a country road with my 15-year-old son. I was distracted by intractable problems going on within my family. Suddenly, I saw a stop sign whizzing by me, and I realized there was no way I could stop in time. We hit a car going 40 miles per hour.

My life was spared that day, and so were the lives of the two women I hit and the life of my son.

But what a scary thing! Imagine how youd feel if you hurt or killed someone because you werent paying attention!

That accident was no accident; I wasnt fully present behind the wheel. I was distracted by problems I was tolerating and not resolving.

Im not alone, of course. How many of us dont attend to the relationship problems at hand? It is common to read about the challenging dynamics of Family-Owned Businesses (FOB):

But what do you do to resolve them? Many FOB leaders dont resolve them; they tolerate them. Their health suffers and their relationships at home become strained. They start counting the days until something changes and their lives at work become easier maybe having extra drinks at night to be able to sleep, maybe staying distracted through working harder and longer, hoping the conflicts will sort themselves out.

The day of my car accident was a huge wake-up call. I decided there in the middle of the road to pay attention in my life, take responsibility and address the problems before me.

Maybe youve had a wake-up call something that shook you to the core and made you pay attention. Maybe not. Either way, we owe it to ourselves to be present, to take responsibility and resolve the problems that plague us in our family and business.

Heres a story to illustrate. Joe called me one day because of his escalating health problems. He was the youngest sibling in a family-owned business and was frustrated at every turn. As we talked, it became clear he was extending early family conflicts into the business today, playing by rules that were established when he was young. He didnt dare take action without express permission and often interpreted his brothers comments through the lens of you dont give me enough credit. He was constantly angry about his lack of power, and it was literally killing him.

What Joe learned is that his own mindset created both the problems and the solutions and that by taking responsibility for everything in his life, he could create major change. For example, when he thought he was being treated with disrespect, that was indeed his experience. When he decided that his perceived lack of respect was just perception, he felt more empowered to enact his vision.

Some people believe that taking responsibility for everything in their life is unrealistic or creates a blame the victim mentality. But in fact, taking responsibility for everything in your life allows you the freedom and opportunity to create the life and business you want.

Theres a saying about the brain that goes like this: Neurons that fire together, wire together. What we believe gives rise to our thoughts, which generate our feelings, which produce our actions, which create our results, which reinforce our beliefs. Our results make us think we were right to believe what we did in the first place! We perpetuate current reality in our brains neural networks and in our lives.

The way out of this loop is to take responsibility for our thoughts and actions and shift our mindset to actually change those original, often unconscious beliefs.

Here are three steps to shift your mindset:

1. Establish your vision: Dwell in possibilities of what you want to see in your business. Dont get stuck on how things currently are, spend time imagining how you want them to be. The brain doesnt know the difference between real and imagined experiences (hard to believe, but true). The more time you spend visualizing the relationships and communication you want to have, the more you will see opportunities to create this.

2. Identify the obstacles: What old family rules have you adopted that youre consciously or unconsciously following? Talk to someone or write for five to 10 minutes to discover how playing with these old rules blocks your effectiveness and satisfaction. One way to discover these rules is to look at whats not working for you, what doesnt feel good in your day-to-day functioning and what would feel more satisfying to you.

3. Make new decisions: If the old rules no longer serve you, decide to establish new rules. Instead of I cant take action without express permission, decide that the fellow leaders in your family trust you and trust your actions. Then take action from a place of integrity. Or, if you feel trapped by a family system and dont believe you can get out, decide there is always a way out. It is amazing what a new decision will do to create a sense of freedom and self-confidence.

The complexities within family-owned businesses abound. This is not new information! When we get stuck in patterns that dont work, when we dont see a way out, when our health or ability to be present in our lives suffers, its important to take responsibility and do whatever is required to resolve the issue.

Sometimes taking responsibility means reaching out and getting some assistance. When our cars break down, we take them to the shop. Most of us dont wait until they break down! We bring them in for oil changes and regular tune-ups.

Do the same for yourself and your family business. Tend to your life and the issues in the family at least as much as you would your car. Take responsibility and see what is possible!

Nancy Jonker, Ph.D, is a mindset coach serving entrepreneurs, family business owners and successful professionals. She aids family business owners in identifying leaders strengths, facilitating conversations and family meetings and improving team functioning.

More:
What does neuroscience have to do with family business? - grbj.com

5 factors raise hospitalization risk for kids with autism – Futurity: Research News

A new study identifies which factors put young people with an autism spectrum disorder (ASD) at high risk of being hospitalized for inpatient psychiatric careincluding factors both related and unrelated to ASD itself.

Children or teens with autism spectrum disorders often come to hospitals when behavioral episodes overwhelm the support that caregivers can provide at homebut resources at hospitals are sometimes limited, too, says Giulia Righi.

The demand is far greater than the number of clinicians, the number of programs, and the number of beds we have, says Righi, a research assistant professor of psychiatry and human behavior at the Warren Alpert Medical School of Brown University, who treats acute care patients with autism spectrum disorders.

The strongest risk factors are not necessarily associated with ASD.

One of the biggest issues is the availability of acute care services such as day hospital programs and inpatient units to support families when their childrens behaviors have escalated to the point of making a situation unsafe at home, at school, or sometimes both, she adds.

Identifying and addressing the factors that make hospitalization more likely, she says, could reduce such instances. Notably, only two of the risk factors identified in the study of patients with an autism spectrum disorder (ASD)their severity of autism symptoms and the degree of their adaptive daily life functioningwere specific consequences of the disorder.

The strongest risk factorsdisrupted sleep, having a mood disorder, and living in a home with a single caregiverare not necessarily associated with ASD.

Our results underscore the importance of a multidisciplinary approach to the assessment and treatment of children and adolescents with ASD that addresses behavioral, psychological and psychiatric, adaptive, sleep, and medical functioning in order to decrease behavioral crises and the utilization of inpatient psychiatric services, Righi and coauthors write in the study published in theJournal of Autism and Developmental Disorders.

The study made unique use of two large datasets with unusually rich information about patients, Righi says: the Autism Inpatient Collection (AIC), which includes data from childrens psychiatric hospitals in six states, and the Rhode Island Consortium for Autism Research and Treatment (RI-CART). Founded in 2013 by a coalition of local institutions including Brown, Bradley Hospital, and Women & Infants Hospital, RI-CART has grown to become a community of about 1,500 patients and their families.

In the research, Righi and her coauthors looked at the AIC records of 218 patients age 4 to 20 who were hospitalized and compared them with 255 age- and gender-matched members of RI-CART who were not hospitalized. By employing statistical analysis techniques, the researchers were able to isolate risk factors that were independently and significantly associated with the risk of hospitalization.

The strongest predictor was the presence of a mood disorder, which was associated with a seven-fold increase in the odds of hospitalization. The presence of sleep problems was the second strongest risk, more than doubling the odds. A high score on a standardized scale of autism symptom severity raised the odds a little bit, though still significantly.

Meanwhile, having a high score on a standardized scale of adaptive functioning, or basic life and coping skills, slightly but significantly lowered the odds of hospitalization. Finally, children and teens in households with married caregivers had only 0.4 times the odds of needing hospital care compared with comparable patients living with only one adult caregiver.

That last result, Righi says, is likely not about family structure or stability per se, but rather about resources available to cope with the care for a child with high needs. The hospitalization risk associated with mood and sleep disorders, meanwhile, points to the need to engage in a broad based and careful psychiatric evaluation of autism patients.

Our findings emphasize the utility of thorough assessment and treatment of mood and sleep conditions to decrease the likelihood of requiring psychiatric hospitalization, Righi and her coauthors write.

Righi notes that some factors she might have hypothesized would be independently significant were not, including the degree of intellectual disability or gastrointestinal problems.

Righi acknowledges that while research examined many factors, others that it didnt measure might also be important. Also, the study measured associations of risk factors with hospitalization but doesnt prove they were the cause of hospital visits.

But the study authors write that the risk factors they identified may be worth addressing before young autism patients reach the point where hospitalization becomes necessary.

In spite of its limitations, the study authors conclude, the present findings reveal indicators that may be useful for identifying children and adolescents at greater risk of psychiatric hospitalization as well as other potential targets for individual and family intervention.

The Hassenfeld Child Health Innovation Institute at Brown University helped to fund the study along with the Simons Foundation, the Nancy Lurie Marks Family Foundation, and the National Institutes of Health.

Source: Brown University

Read the rest here:
5 factors raise hospitalization risk for kids with autism - Futurity: Research News

Weekend: Elementary school classroom gets ‘egg-cited’ – The Courier

By KAREN McDOUGALL The incredible egg. An incubator filled with fertilized eggs was the star of a three-week stay in an elementary school classroom when I was the 4-H program assistant. Why? One of the school enrichment programs is the chick embryology program, Hatching Future Scientists. Along with the fertilized eggs, there were many questions and much learning. When going into the classrooms, the students always asked how long it would take for the eggs to hatch. It takes about 21 days. To make this real for the students, a hatching book was created. Starting with day one, this book gave a day-by-day look at the development of the chick inside the egg. We talked about why the chickens laid colored eggs: white, brown, blue or green. How? The color of the chickens earlobes determined the egg color. Chickens with white earlobes lay white eggs. Chickens with red earlobes, the students would say lay red, but these are the ones who lay the brown, blue or green eggs. Most of our eggs were brown eggs and were specific breeds. We could tell if they were male or female by their color after they hatched. Have you ever noticed the white spot or germ spot on the egg yolk? This is where the chick will start to develop if the eggs are fertilized. When a hen sits on her eggs, her body heat incubates the eggs. She turns them with her beak, which is part of her maternal instincts. The average clutch a hen hatches is 12 eggs. The students asked where the developing chick got its food. Nutrition comes from the yolk. It was quite interesting to process. Our incubator had a turner, which would turn the eggs every 30 minutes. If the humidity or temperature is off, the development and hatching of the eggs is affected. Fertile eggs are set in the incubator on the first day in the classroom. Humidity and temperature controls are carefully monitored. Between 38 and 60 hours after the eggs begin to incubate, many things start happening inside the eggs. The heart is beating. The upper part of the embryos body turns on its side. The eyes, ears and brain take shape. On days four and five, wings and legs are growing and the chick is moving inside the egg. On day nine, the eyelids form and on day thirteen the eye closes. One highlight for the students is candling the eggs. This is done around day 10. What is candling? Shine a small light into the large end of the egg, darken the room and we are able to see inside the egg. Seeing nothing means the egg is not fertile. One sign of a developing chick is the blood vessels growing around the embryo. Many times a black dot is visible, which is the chicks eye. If conditions are right, the students are able to see the chick move inside the egg. During my second visit, we did eggsperiments. Spinning eggs indicated if we had a raw or hard-cooked egg. Eggs that float indicate whether they are spoiled or good to eat. The answers? Hard-cooked eggs spin faster. If the egg floats, throw it out. On day 18, the egg turner is unplugged so the chicks can get themselves ready to hatch. The chick makes a small hole in the egg shell, then pecks its way around the egg. When completed, the chick makes its appearance in the classroom. Once the chicks are dry, the teachers put them in a special container with food and water. The students are able to hold them and feel how soft and delicate they are. By the time I stopped to pick up the chicks, they were starting to have feathers on their little wings. What an egg-citing time that was! Students named their little friends. Many of the students wanted to take them home, but I always shared that I was taking them to a neighbor who would take care of them. It takes about 26 weeks for the pullets to start laying; since they are young hens, they will be laying the smaller eggs. Have you ever found a double yolk? While the hens are getting their bodies in sync with laying, you may find an extra bonus. Laying hens typically lay an egg roughly every 24-27 hours and produce 200 to 300 eggs per year. As the hen gets older, her eggs will get larger. It was an egg-cellent time for these students to see a miracle in their classroom, from an egg to a chick. McDougall is the SNAP-Ed program assistant at the OSU Extension of Hancock County.

comments

Continue reading here:
Weekend: Elementary school classroom gets 'egg-cited' - The Courier

The ‘Lifestylization’ of Politics – National Review

EDITORS NOTE: The following is Jonah Goldbergs weekly newsletter, the G-File. Subscribe here to get the G-File delivered to your inbox on Fridays.

Dear Covfefe,

I will admit upfront that I have a pretty good gig, writing-wise. No one really tells me what to write, particularly in this newsletter. I have no lane, as it were. I can go anywhere I want Alger Hiss was guilty! I like eating cold chicken over the sink! Cows, when cooked properly, are delicious! Hail Orb! Etc!

Still, even as a generalist, there are some topics that arent a natural fit for me. I rarely write about sports. I cant remember the last time I weighed-in on relations between Peru and Singapore or why I might spare One Directions lives if I were czar. I dont review video games, miniature-horse rodeos, or Canadian pornography. But I will confess that, if I wanted to, I could. And, if someone out there wants to pay me to share my musings I will be happy to discuss terms.

I bring this up for the simple reason that I want to head off a specific asinine rejoinder that is so prevalent in this remarkably stupid moment: If its okay for you to do it, why cant I?

My short response to this is: Because this is my job.

This is a long way around to get to what should have been my lede: Stay in your lanes, people.

The other day, the guy behind one of my favorite Twitter feeds, @Dog_rates, announced that he would donate half of the proceeds from a jokey anti-Trump hat to Planned Parenthood. I was among the first to criticize him. I didnt dispute his right to do what he had in mind, but I said it was a terrible business decision for the rather obvious reason that Planned Parenthood is polarizing.

Theres a reason why lots of businesses dont want to be seen as political i.e., because they want to maximize the number of their customers. If you start hawking liberal widgets, you are closing yourself off to conservative widget buyers, and vice versa. Of course, some business models involve finding market niches, but ideally you want to sell to everyone. A dog-themed Twitter account is already something of a niche, but since only monsters dont like dogs, its a pretty broad niche. Picking sides on one of the most divisive issues of our time abortion may be a principled thing to do, but purely on business terms it was a bad idea, as anyone whos watched Seinfeld could have told him.

Now, Im not going to rehash all of it here (Ian Tuttle has two good posts on the situation here and here). But I will say that I would have made the exact same argument if @Dog_Rates had promised to donate money to pro-life groups, a point my left-wing critics seem to have a very difficult time processing.

Anyway, it looks like I was right that Matt Nelson, the operator of the account, hadnt thought the whole thing through when he came up with the idea, and he tried to backpedal as best he could, which then in turn pissed off the proPlanned Parenthood crowd. As best I can tell, hes even taken down his semi-apologetic statement. Thats what happens when you blunder into a no-win situation.

Now consider this tweet rant from the ACLU:

I have no doubt the ACLU sincerely believes all of this. But you know what? Climate change isnt in the American Civil Liberties Unions portfolio. The ACLU is supposed to be concerned with wait for it civil liberties. I think it has been drifting off that beat for a long time. But this tweet is truly remarkable and remarkably dumb. The ACLU depends a great deal on its reputation as a non-partisan defender of constitutional rights. It puts that reputation at risk when it starts soapboxing about climate change. What does it gain from this as an institution? The people who already agree with these tweets dont need to be persuaded, and the people who dont will not be persuaded by them. But they will or might be further convinced that the ACLU is just another partisan political outfit. Credibility is a difficult resource to accumulate and an easy one to squander.

Maybe the ACLU is too far gone to be a good example of what Im talking about. But the problem is everywhere. From news anchors and reporters all but giving up any claims to neutrality on the issues of the day, to judges who must virtue signal their distaste for Trump, to actors who think that they are full-time pundits who play make-believe on the stage and screen as a side hobby.

Almost every morning I see this GE ad.

Ive seen nary a critical word about it, even though it is nothing more than corporate political propaganda. But since its propaganda all the right people support, they dont even pause to think about how they would respond if it pushed a political message they dont like. Its like my old rants about NBCs Green Week. Imagine if ABC came out with a pro-life week in which they incorporated positive messages about fighting for the unborn in their news broadcasts and sitcoms. The same people cheering @Dog_Rates would be burning cars in the streets.

Peanut Butter Cup America

Its a familiar conservative lament to say this is all part of the politicization of everything. And I think thats true. But you can flip it on its head, too. Everything is becoming lifestylized (I hereby decree thats a word). Its like that ancient debate between Plato and Socrates: Did Socrates get his chocolate in Platos peanut butter or did Plato get peanut butter in Socrates chocolate? (That sounds dirty The Couch.)

Scads have been written, mostly by conservatives and libertarians, about the problem of politics bleeding into the nooks and crannies of traditionally apolitical life. And I agree with much of it. But far less has been written about how lifestyle is creeping into politics. With the decline of traditional religion and other mediating institutions, the primary source of identity for ever larger numbers of people is partisan affiliation. Indeed, partisan affiliation for the first time ever is often more predictive of behavior and attitudes than race, ethnicity, religion, and gender. Thats bananas.

But its also utterly predictable. When politics becomes a secular religion, a source of meaning, or simply a lifestyle, politics will be less about arguments and tradeoffs and more about wearing ideas on your sleeve. I agree with Jonathan Last when he writes that the current hysteria over the Paris pullout is virtue signaling about virtue signaling. But what else can you expect when people start wearing their partisan affiliation the way people once wore a crucifix or Star of David?

Disagreements become insults when politics becomes a statement about who you are. And, as I keep saying, that explains why so many now define free speech as assault and assault as free speech.

Rights and Science

What do the passionate cries of science denier and calls for prosecuting Kathy Griffin have in common? They conflate amoral processes with moral stances.

This is difficult to explain, so give me a minute. Neil deGrasse Tyson notwithstanding, science is not moral. It is not a source of values. Scientists can do extremely evil things or extremely noble things. Science is a method and a tool. But the freedom to do science is a wonderful thing because a society with healthy guardrails can harness science to wonderful ends. Think of fire. Fire has no morality. It can be used to burn down a home and it can be used to cook a meal. Our legal, cultural, and moral guardrails make these distinctions constantly. We dont let mad scientists use humans for experiments without their permission, even though I could make a perfectly rational argument that if we gave scientists a free hand, we could get more medical breakthroughs more quickly. What are a few eggs if we get a better omelet? Etc.

If you read left-wing Twitter, this is a source of remarkable confusion for many people. Every day, I see a tweet from someone saying that you must believe in science when it comes to climate change and another tweet from someone else saying that science is a tool of oppression and racism. How can science be righteously authoritative on environmental policy but cruel and bigoted when it comes to the science of embryology or sexuality?

Something similar holds for our rights. We have all manner of rights to do wrongs. For instance, as Kat Timpf and Charlie Cooke have been insisting, what Griffin did with that beheaded effigy of Donald Trump was stupid and repugnant. But at the same time, she had every right to do it, and thats a wonderful thing.

Charlie is right. But there is a tension. Just as Griffin has every right to do what she did, she was also wrong to do it. This is a distinction people get profoundly confused about on both the left and the right.

For instance, when it was reported that General Michael Flynn (Ret.) would invoke his Fifth Amendment rights, many of his defenders shrieked that we shouldnt count that against him in any way. As a legal matter, thats correct. But theres nothing wrong with making judgments about it either. It looks bad, even if Flynn is within in his rights.

If youre going to get on your high horse about how its unfair to leap to conclusions when someone pleads the Fifth, then I can only assume you condemned this:

Whats interesting to me is the way that people talk about rights as if they have moral content to them. How dare you judge me for exercising my rights!

There is an infinite menu of things I can do with my rights that would be immoral or unethical, just as there is an infinite menu of things scientists can do with science that would be immoral, unethical, and illegal.

Americans have the right to say horrible things on Twitter in response to a terrorist attack on a bunch of young girls. They have the right to associate with Klansmen. They have the right to worship Satan. They have the right to do all manner of gross, tacky, weird, and unspeakable things with their own property and in their own homes. Indeed, they have the right to sit around all day wearing Indy 500 Rompers and eating lettuce jam while watching Donnie Darko. But in these and in so many other things, I have the right to make judgments and to criticize based on those judgments. Whether my judgments are fair and my criticisms are sound has no bearing on whether I have the right to them.

Why should the Fifth Amendment be any different? The Fifth Amendment is the right that ensures a fair process. Thats all. Its not a source of meaning or moral direction outside that process.

Morality only enters the picture when you look at the system as a whole. The trees can be bad, but the forest is good. As I wrote in this much better newsletter, the essence of conservatism can be defined as comfort with contradiction. People have the right to do wrong and people have the right to condemn, shame, and boycott people who do wrong. Saying you had the right to do x is a universally valid defense in only one venue: a court of law. Outside the dock, there are higher standards or there should be.

The problem with the lifestylization of politics most acutely on college campuses is that people want to clear away the contradictions. They want a unity of goodness where all good things go together and bad things are given no quarter. This has chiefly been a problem on the left, but it has become increasingly bipartisan. Why? Because right-wing populism is a lifestyle too:

Everywhere you look, people are mistaking inconvenient facts for insults. Every single day, people are taking offense at disagreement and confusing rights (and presidential prerogatives) and science for moral authority. Its a hothouse where the air is thick with hypocrisy because arguments are downstream of feelings and where facts are so much flair to don or discard depending on what lifestyle you want to adopt and what virtues you want to signal. In short, its a very stupid time.

Various & Sundry

As Michael Knight said to Kitt, I want to change gears a little. Kevin Williamson has a very nice plea for your support today. In his own inimitable way, he corroborates the point I made above:

National Review took a principled and even at the time unpopular stand against the man who would go on to become the Republican presidential nominee and, incredibly enough, president. I was not the most restrained voice on the issue. I am sure that this resulted in some canceled subscriptions and withheld donations, but I never heard much about any of that. I get a lot of feedback on my work from the editors here Do you think this is really fair to the other sides argument? Are you sure about the numbers here? Do you really need a 121-word lead? but its never: Dont write that because it will annoy x donor or y advertiser.

If you are wondering what your donations and support go to, thats it: maintaining a conservative institution that lets a lot of different writers with a lot of different opinions write what they think without worrying about anything other than producing the best work they can. Its a big part of what allows National Review to operate as an opinion journal in which this is remarkable, if you think about it there is no party line. If theres a live political dispute that Ramesh Ponnuru, Rich Lowry, Andrew C. McCarthy, Reihan Salam, Jay Nordlinger, Mike Potemra, Rick Brookhiser, Kat Timpf, Veronique de Rugy, Ian Tuttle, Alexandra DeSanctis, and I all agree about...I cant think what it is.

Now, if youre like me, you may be wondering why he left me off that list. Maybe Kevin knows something I dont know? But putting that aside, hes making an important point. National Review has writers who exult in Donald Trump and it has writers who dont. I dont think we have any writers who take a position of blanket opposition to him. There are no members of the resistance here. But there are plenty of people who understand that conservatism is more than a lifestyle, better than pure team partisanship. In short, we believe in making arguments, standing athwart GroupThink. And the fact that so many friends and readers have trouble with this is a testament, at least in some small part, to the extent of the lifestylization of American politics. If you feel that way, youre probably not reading this anyway.

But if you appreciate it, if you think America needs more institutions that think arguments and facts matter even when they are insulting to people on the left or the right then we would be extremely grateful if you could show your appreciation. If you cant, we understand. Life is complicated, which is sort of the whole point.

Canine Update: Things have been a bit complicated on the dog front this week. Pippa developed a bad limp earlier in the week, but seems to be on the mend. Its a sign of how traumatized my wife and I were by the Late Great Cosmo The Wonderdogs medical troubles that we greet every limp as a potential crisis. Cosmo was beautiful, tough, and smart, but he was also built like an East German car. Before he died, Cosmo was about two surgeries shy of being fully bionic. We dont know how the Spaniel hurt herself, but we fear it might be that Zo and Pippa might play too rough when the humans are gone. My wifes new job has necessitated a lot more alone time, and theres evidence to believe that Zo takes out her boredom on Pippa much like Ramsay Bolton did on Reek. We hope thats not the case. But Im sorely tempted to get a nanny cam to get to the bottom of it. Meanwhile, it means that when were home, Zo is far needier.

In other news, Zo is fascinated by turtles and covfefe. In feline news, when the Fair Jessica and I were in New York over Memorial Day, our dogwalker/sitter/aunt reported that around 11:00 oclock at night, Zo went bonkers and started barking out an open window. Kirsten looked outside and saw that Gracie, the Good Cat, was staring down a fox in the middle of the street. Between Zos barking and Gracies willful glare, the fox turned tail (literally!) and ran away. It could have ended very badly. But now Zo and Pippa look upon Gracie as a kind of folk hero.

Heads Up: Ill be on ABCs This Week on Sunday.

ICYMI...

Last weeks G-File.

My short (mostly negative) review of Alien: Covenant.

My response to Dennis Pragers take on Trumps right-leaning critics.

Why government-provided health care doesnt necessarily lead to better health.

Laffaire covfefe.

My Special Report appearance from Wednesday night.

Why cant Hillary accept blame for her 2016 loss?

And now, the weird stuff.

Debbys Friday links

Two mating camels cause a traffic jam in Dubai

Little girl rescues runaway dog with love

When deja vu is strong enough that you dont know whats real

A garden of poison plants

When Nazis tried to bring extinct animals back to life

Behold: a new species of carnivorous sponge

Great White shark launches itself into Australian fishermans boat

Science: Your meanest friend just wants the best for you

School in France testing facial recognition tech to keep students paying attention

Love-hormone injections turn gray seals into best friends

What does the edge of the universe look like?

The strange and surprising second life of Harambe

Five hundred years after the Protestant Reformation began...a robot priest

The most misspelled words in every state

Mathematical proof that your life is interesting

Newborn walks minutes after being born

Read the original here:
The 'Lifestylization' of Politics - National Review

Reliance on Foreign Tech Puts Strain on China’s Genetics Market – Sixth Tone

In 2007, Shanghai launched a project called Eastern Scholars, which provided funding to lure distinguished academics to the city to reinvigorate academic programs at top universities. The program provided the impetus for my 2009 move to Fudan University, where I ran the nanofabrication lab. Now, however, my goal is to provide the technology necessary to treat diseases using DNA sequencing. In the next couple of years, I hope to make this a viable option for the majority of Chinese patients, and as quick and easy as drawing blood.

After three years as an Eastern Scholar, I decided in April 2015 to start my own gene sequencing company, Turtle-Tech. The name is a play on words: In Chinese culture, turtles are symbols of longevity; in Chinese language, the word for turtle haigui can also refer to someone who returns to China after studying abroad. This reflects my own experience as a student in Sweden, where I worked on a project to develop a gene sensor using semiconductors.

Genetic testing allows scientists to examine a persons DNA from, say, a blood sample. In addition to providing medical diagnoses, it can also be used to see how likely it is that someone will contract a given disease in their lifetime. It can even be used in cancer screenings, to test a patients susceptibility to certain types of cancer, and thereby help them to prolong their life. Currently, there are over 1,000 diseases that can be diagnosed using genetic technologies.

The DNA sequencing industry has grown rapidly in recent years, with the global market for sequencing services growing from $7.94 million in 2007 to a predicted $11.7 billion by next year. It is estimated that this market will continue to grow by more than 20 percent annually over the next 10 years.

In China, DNA sequencing services began popping up onlineas early as 2006. Since 2009, health management centers at some of the countrys top-ranked provincial and municipal hospitals have offered genetic testing as part of physical examinations. The barriers for clinical application remain high, however, due to the fact that the genetic testing industry and its products still constitute medical instruments requiring supervision. In practice, this means they are required to pass clinical trials and be approved by the China Food and Drug Administration (CDFA) before they can be used for medical purposes.

People soon discovered, however, that although the barriers to clinical use are quite high, DNA sequencing holds a potentially vast commercial value. In advertising, such technology is frequently portrayed as having almost miraculous effects: It can prevent illness, help you lose weight, unearth hidden talents, even trace your ancestry. The fact that current technology is not mature enough to guarantee these benefits does little to persuade people that a product this impressive wont be in high demand in the future.

In China, there are currently two main types of sequencing companies in the industry. Most of the first kind entered the market more than five years ago; they include companies like BGI, NovoGene, Berry Genomics, and BasePair. These companies largely emerged out of the scientific research industry, and are primarily focused on offering medical testing services. The second kind consists of companies that have entered the market in the past two years. This group, which includes the likes of WeGene, G-Cat, Somur, M+ Gene, and QuantiHealth, primarily market their technology to ordinary consumers.

Recently, in the battle for market share, the second set of companies have started diversifying their products. Now, in addition to letting consumers test their own DNA, they are also engaged in a major price war, with tests costing only 300 to 400 yuan ($43 to $58). They also offer products aimed at weight loss, nutrition, fitness, and early education.

Against this background, newcomers to the market immediately find themselves on their heels. First, if you want access to the medical testing market, your product must win approval from the CFDA, after which you still need to come up with a way to persuade hospitals to buy your products. If the commercial market tickles your fancy, you have to face up to a nagging doubt at the back of consumers minds: Is genetic testing actually of any use to me?

The number-one barrier to the growth of the genetic testing industry is one of knowledge. While China has made impressive strides in the field of DNA sequencing, its data capabilities have yet to catch up to more developed countries, and China still lacks a national DNA database. This data is important for carrying out research and developing our overall knowledge of genetics. Those of us involved in bioinformatics essentially turn that raw data into knowledge, then use this knowledge to make inferences and deductions about human health.

But certain limitations are keeping genetic testing from living up to its full potential. At present, DNA testing kits run anywhere from a few hundred to a few thousand yuan, but according to some radical viewpoints, they should be made totally free to anyone who wants them. The problem is that the exact implications of genetic testing results are not yet clear. While gene editing technology makes for enticing headlines, it is not ready for widespread use as an method for curing disease.

As a leader in DNA sequencing, China began adopting the precision medicine model which focuses on making health care customizable and personalized only a few months after the United States. Currently, the two countries are keeping pace with one another in this field. However, due to an effective duopoly on key technologies by American companies Illumina and Life Technologies, China is restricted in its research into DNA sequencing and treatments involving genetic manipulation.

The development of DNA sequencers and their accompanying chemical reagents is largely dependent on foreign capital, with the two aforementioned American firms having achieved dominant positions within the industry. Their market dominance is compounded by the continuous rise in prices of key materials and reagents. The price of a single gram of imported polymerase the enzyme that builds DNA is comparable to that of gold. Creating a domestic variant of polymerase, however, would mean Chinese companies could lower this price significantly. By developing homemade versions of the necessary machine components, sequencers could be produced for around one-third of what they cost to make overseas, and possibly even less.

The initial wave of startups since 2015 has now receded, and the Chinese genetics industry is undergoing a lull in investor interest. DNA testing itself has also entered an awkward phase, with domestic and foreign research organizations having hit a technological plateau. Given the inherent limits of genetic technology, it may be necessary to wait until both it and the market has matured further before it can reach its full potential. For me, personally, I hope that my little Turtle-Tech can stay afloat through these rougher waters, and that we will be ready to offer competitive products to the Chinese genetic testing industry when the tide finally does come back in.

Translator: Kilian ODonnell; editors: Lu Hongyong and Matthew Walsh.

(Header image: A laboratory technician transfers a sample for a genetic test in Chongqing, April 9, 2015. VCG)

View post:
Reliance on Foreign Tech Puts Strain on China's Genetics Market - Sixth Tone

Myriad Genetics’ EndoPredict Test Receives New Coverage From 17 Insurance Plans – GenomeWeb

NEW YORK (GenomeWeb) Myriad Genetics announced late Friday afternoon that 17 new insurance plans have released positive coverage policies for its EndoPredict breast cancer test.

The plans include Blue Shield of California, Humana, and multiple regional plans. Further, Myriad said, Highmark Blue Cross Blue Shield, Independence Blue Cross, and Health Care Service Corporation have posted positive coverage policies which take effect in July 2017. These plans altogether represent more than 35 million covered lives raising the total of lives covered for EndoPredict to 109 million.

Registering provides access to this and other free content.

Already have an account? .

Read more:
Myriad Genetics' EndoPredict Test Receives New Coverage From 17 Insurance Plans - GenomeWeb

Bristol-Myers and Seattle Genetics move a promising flagship combo into PhIII – Endpoints News

Jonathan Drachman, Seattle Genetics CMO

Late last year investigators for Bristol-Myers Squibb $BMY and Seattle Genetics $SGEN turned up at ASH with some stellar pilot data from a Phase I/II combination study matching Opdivo with Adcetris. In addition to a 90% objective response rate in a small group of patients, the team also tracked a 62% complete response rate among treatment-resistant patients for classical Hodgkin lymphoma.

Now the partners want to see if they can get similar results in a pivotal Phase III matchup.

The two companies headed to ASCO this morning with an announcement that theyll be pushing into the Phase III soon, which will compare the combo against Adcetris as a monotherapy.

The move into Phase III comes as the first wave of hundreds of Phase I/II exploratory studies have begun to deliver a trove of data about the potential of these new combos. This week EP Vantage highlighted 765 combination studies in the industry pipeline as cancer combos become one of the hottest tickets in drug R&D. And a new slate of Phase III studies including a recently announced slate of pivotal tie-ups for Incyte point to the near-term introduction of new, more effective therapies.

The addition of Adcetris and Opdivo helps illustrate the potential. Opdivo, like 4 other approved PD-(L)1s, dismantles a brake cancer cells have been able to put on an attack by immune cells. Adcetris is a targeted attack. And theres a large second wave of PD-(L)1s coming through the pipeline.

This is just the first of what could potentially prove to be a series of late-stage studies for these two companies, which have also been running through trials on a range of indications focused on relapsed or refractory Hodgkin lymphoma and CD30-expressing relapsed or refractory non-Hodgkin lymphomas. The studies include T-cell lymphomas, diffuse large B-cell lymphoma (DLBCL), and other rare subtypes of B-cell malignancies, including mediastinal B-cell lymphoma and mediastinal gray zone lymphoma.

Seattle Genetics CMO Jonathan Drachman said:

We are evaluating Adcetris in novel combinations in order to identify optimal treatment regimens for patients with CD30-expressing lymphomas. We are pleased to expand this collaboration with Bristol-Myers Squibb to evaluate Adcetris compared to the combination of Adcetris and Opdivo in a pivotal phase 3 study in relapsed Hodgkin lymphoma.

News reports for those who discover, develop, and market drugs. Join 16,000+ biopharma pros who read Endpoints News articles by email every day. Free subscription.

See the original post:
Bristol-Myers and Seattle Genetics move a promising flagship combo into PhIII - Endpoints News