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Mitochondria Behind Blood Cell Formation – Northwestern University NewsCenter

Mitochondria are tiny, free-floating organelles inside cells. New Northwestern Medicine research has discovered that they play an important role in hematopoiesis, the bodys process for creating new blood cells.

New Northwestern Medicine research published in Nature Cell Biology has shown that mitochondria, traditionally known for their role creating energy in cells, also play animportant role in hematopoiesis, the bodys process for creating new blood cells.

Historically, mitochondria are viewed as ATP energy producing organelles, explained principal investigator Navdeep Chandel, PhD,the David W. Cugell Professor ofMedicinein the Division ofPulmonary and Critical Care Medicine. Previously, my laboratory provided evidence that mitochondria can dictate cell function or fate independent of ATP production.We established the idea that mitochondria are signaling organelles.

In the currentstudy, Chandels team, including post-doctoral fellow Elena Ans, PhD, and graduate students Sam Weinberg and Lauren Diebold, demonstrated that mitochondria control hematopoietic stem cell fate by preventing the generation of a metabolite called 2-hydroxyglutarate (2HG). The scientists showed that mice with stem cells deficient in mitochondrial function cannot generate blood cells due to elevated levels of 2HG, which causes histone and DNA hyper-methylation.

This is a great example of two laboratories complementing their expertise to work on a project, said Chandel, also a professor ofCell and Molecular Biologyand a member of theRobert H. Lurie Comprehensive Cancer Center of Northwestern University.

Sam Weinberg, a graduate student in the Medical Scientist Training Program, and Lauren Diebold, a graduate student in the Driskill Graduate Program in Life Sciences, were co-authors on the paper.

Paul Schumacker, PhD, professor of Pediatrics, Cell and Molecular Biology and Medicine, was also a co-author on the paper.

Chandel co-authored an accompanying paper in Nature Cell Biology, led by Jian Xu, PhD, at the University of Texas Southwestern Medical Center, which demonstrated that initiation of erythropoiesis, the production of red blood cells specifically, requires functional mitochondria.

These two studies collectively support the idea that metabolism dictates stem cell fate, which is a rapidly evolving subject matter, said Chandel, who recently wrote a review in Nature Cell Biology highlighting this idea. An important implication of this work is that diseases linked to mitochondrial dysfunction like neurodegeneration or normal aging process might be due to elevation in metabolites like 2HG.

This research was supported by National Institutes of Health grants R35CA197532, T32GM008061, T32 T32HL076139, K01DK093543 and R01DK111430, and Cancer Prevention and Research Institute of Texas New Investigator award RR140025.

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Mitochondria Behind Blood Cell Formation - Northwestern University NewsCenter

Beauty brands embrace the appeal of neuroscience – Inquirer.net

Mood-boosting beauty pioneer Benefit Cosmetics continues to lead the feel-good retail movement. Image: Benefit Cosmetics US/Instagram via AFP Relaxnews

According to recent findings by top think tank Peclers Paris, more and more millennial fashion and beauty brands are tapping into the strong consumer demand for mood-oriented products and interaction.

Leading brands such as Benefit Cosmetics are eschewing traditional marketing spiel in a move to create a closer emotional connection with their consumers.

A no-brainer, if you follow leading expert on emotions Antonio Damasios reasoning that 80 percent of our choices and decisions are driven by our emotions.

Biometrics and neuroscience are being brought into the mix to enhance our overall retail experience. Face reading and mood-tracking technologies are examples of these new ways of garnering interest and enticing shoppers to come back for more.

Japanese clothing brand Uniqlo was one of the pioneers of the trend back in 2005 when it launched UMood, algorithm-based brainwave sensing technology that was designed to help customers find the perfect t-shirt from 600 styles, to suit their emotional state.

Beauty brands often use seductive product names in the hopes of tapping into consumers deep-seated desires.

Cliniques Happy fragrance and Benefits Dr Feel Good complexion balm; the list goes on. While the concept of mood-boosting fragrances or makeup is not new, digital marketers are going the extra mile by lavishing more attention on consumers moods and general well being.

Benefit is a case in point. The San Francisco-born beauty giant has built its reputation on playfully engaging with consumers, announcing, for instance that laughter is the best cosmetic despite boasting an army of best-selling beauty products.

Earlier this year, Benefit raised brows with the launch of its brow translator tool. The mood-gauging microsite unabashedly surfs the browcentric beauty trend, thanks to the likes of Cara Delevingne, enabling internet users the opportunity to upload pictures of their eyebrows and find out what they say about them.

With the help of neuroscientist Dr. Javid Sadr from Canadas University of Lethbridge, Benefit came up with a face-reader, which analyses the upper part of the face to determine emotional expression and adds an enhancing effect. Arched, narrow, knitted, neutral; our brows speak volumes about how sassy, happy or sad we are feeling.

Benefit captured their market research in this video, showing passers-by how to define their brows with their online brow translator.

Meanwhile, indie brand Chaos Makeups buzzed-about, soon-to-be launched Mood Cream not only plays upon a changing emotional connection between product and user in its name but also has nostalgic appeal by evoking thermochromatic mood rings from times past. The multi-purpose color-shifting cream changes color with exposure to water or heat. JB

RELATED STORY:

Heres the Deal Behind Alicia Keys #NoMakeup Music Video Look

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Beauty brands embrace the appeal of neuroscience - Inquirer.net

Human Behavior Creates Predictable Chart Patterns – Investing.com

It was an interesting week in the stock market, with plenty of fear and greed to go around. Same as it ever was, right? As we analyze emotions and behavior they seem to parallel the price action in markets. Excessive greed pushes prices ever higher, We saw new highs this week in names like Amazon (NASDAQ:) and Google (NASDAQ:), while all of the most prominent indices at some point hit record highs during the week.

As prices continue to rise volatility shrinks and the perception about market action becomes more 'predictable', and that could be troublesome. Anyone who tries to predict market action and behavior has certainly seen his share of losses - especially if it was down. Oh, we have seen downside over the years, but the longer term trend has been higher as the moves lower have been steep, sharp and quick.

As we analyze price patterns we see behavior show up in recognizable patterns. Let's study the chart of recent high flyer NVIDIA (NASDAQ:). This stock was the top mover in the last year, up a stunning 300%. Many believed those days were behind it and most likely the stock was going to head sideways for an extended period. The stock hit new all time highs last week and pushed much higher than anyone would have expected. But as we can see from the daily chart, at least in 2017 there have been a few interruptions, and we have just seen another if the previous pattern plays out again.

Earlier this year, NVIDIA encountered two nasty selling days on heavy volume, and as we would expect there was followthrough to the downside. These followed sharp moves to the upside. Those trying to catch a falling knife were bloodied and beaten up by not waiting for the selling to subside. Prices did eventually rise however, and this last move from the 102 area in May up to 167 was just stunning.

But look at the poor action June 9 and we can see the setup for more downside first before the stock may head back up. Clearly the fear was evident by the extreme selling and massive turnover. Higher price levels were rejected and when that happened the floodgates opened and sellers hit the bid very easily. This follows the pattern of behavior of sellers in previous price breaks, the odds and probabilities favor more downside here.

While the exact pattern the stock may follow is a guess, we can discern from the chart where support lies, at the recent breakout level, around the 130 price zone. This was a place buyers were aggressive. This would be about 15% lower than the close last Friday, and would be an area of interest IF price stops its decline.

Bottom line, follow the patterns of charts to key in on areas of interest, as these patterns are indicative of human behavior, fear and greed.

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Human Behavior Creates Predictable Chart Patterns - Investing.com

Style anatomy: With Daneese Ali – The Express Tribune

The super-stylish fashionista breaks down her style. Find out all her style secrets and learn the dos and donts

The super-stylish fashionista breaks down her style. Find out all her style secrets and learn the dos and donts in her fashion rulebook

Understanding your body is the key to looking good and a trait found amongst all impeccably dressed fashionistas. While people shy away from talking about their bodies, these brave souls explain how they work their anatomies to their advantage

How would you describe your body type?

Im tall, slim and slender. I have a straight figure, and Im glad. Im not one of those girls who like curvy or voluptuous figures anyway!

Has your body type changed over the last five years?

I wanted to get rid of my baby fat so I became proactive about going to the gym and dieting. But the one thing I never gave up on was sweets. Its a necessity in ones life!

How has your style changed over the years?

I dont really think my style has changed because Ive always kept it classy and simple, and I think that never goes out of fashion. At most, I experiment with whatevers trending but if it doesnt suit me then its a big no! Fashion for me is what you feel comfortable in.

In your opinion what is your most troublesome area?

Im happy with the way my figure is but I can be self-conscious about my calves. They are chunky compared to the rest of my body.

How do you dress your body according to your body type?

Since Im slim and slender, I like to add curves to my frame with peplum style dresses and tops. Im obsessed with bootleg jeans and trousers because they are great for slender women as they add shape and dimension. I also feel skinny jeans look fabulous on me. To be honest, I feel I can carry off most styles because I dont have a full figure and hence I wont end up looking vulgar. A long top or sweater with culottes or skinny jeans is my everyday casual look.

In your opinion what is the biggest mistake a person can make while dressing here?

The biggest mistake women make is showing too much skin. I strongly believe that showing too much skin doesnt make you look sexy! Also, dont hide in the folds of your baggy outfit and dont try to squeeze yourself into something just for the sake of being able to say Im a size so-and-so. Thirdly, playing up your outfit with a couple of carefully chosen pieces of jewellery is a definite do. I really admire women who have the talent to mix and match and can pull off a new trend. Overdoing it however, is one of the worst fashion mistakes out there and probably something you want to avoid. Lastly, women here dont dress according to their age. They dress more maturely and it makes them look much older. You have your whole life ahead of you to dress maturely; dont take away your youth and innocence already!

Which silhouettes suit your body the most?

I dont wear a specific style of silhouette that suits my body because no matter what I wear, I make it my own. Also, Im lucky because I have a petite frame and I can easily fit in all sorts of ensembles.

What is the one piece of clothing that you shy away from wearing and why?

What I have and always will avoid is low necklines. I feel it is very inappropriate and vulgar to show your cleavage. I dont think Ill ever be comfortable with that.

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Style anatomy: With Daneese Ali - The Express Tribune

Merfolk Physiology | Superpower Wiki | Fandom powered by Wikia

Merfolk Physiology Power/Ability to:

Use the traits of merfolk

The power to use the abilities of Merfolk. Variation of Mythic Physiology and Fish Physiology. Not to be confused with Fish People Physiology.

User with this ability either is or can transform into a merfolk (male or female), a beingwith the upper body of a humanoid and the lower body (in taur-style) of a sea animal/creature (mainly either that of a fish or cetacean). Some are able to transform completely into humanoid form to move on land and some can split their tail into legs. Others have to find other ways to move while on land.

Merfolk are sometimes depicted as perilous creatures associated with floods, storms, shipwrecks, and drowning. In other folk traditions (or sometimes within the same tradition), they can be benevolent, bestowing boons, teaching or even falling in love with humans.

See Also: Our Mermaids Are Different.

Merna the Merhog (Adventures of Sonic the Hedgehog)

Mermista (She-Ra: Princess of Power)

Sofia the First (Sofia the First)

Alim Coelacanth (Teenage Mutant Ninja Turtles 1987 TV series)

Merpeoples (American Dragon: Jake Long): Silver...

Sirena Von Boo (Monster High)

Meeshell Mermaid (Ever After High)

Aryana Mendez (Aryana) is carried by her friend Paul.

Rikki Chadwick (H2O: Just Add Water)

Cleo (H2O: Just Add Water)

Emma and Rikki (H2O: Just Add Water) swimming in mermaid form.

Emma Gilbert (H2O: Just Add Water)

Isabella "Bella" Hartley (H2O: Just Add Water)

Nixie, Lyla, Zac, and Sirena. (Mako Mermaids)

Zac the Merman (Mako: Island of Secrets)

Marina (Adventures of the Little Mermaid)

The seven Mermaid Princesses (Mermaid Melody Pichi Pichi Pitch): Lucia, Hanon, Rina, Caren, Noel, Coco, and Seira.

Meroune Lorelei (Monster Musume)

Sun Seto (My Bride is a Mermaid) in human form...

Madam Shirley (One Piece)

Shirahoshi (One Piece) is the Mermaid Princess who has the unique power to communicate with Sea Kings.

The Swimming Club mermaids (Rosario + Vampire)

Tamao Ichinose (Rosario + Vampire)

Pia (Rune Factory) in human form.

Mermaid (Valkyrie Crusade)

Mermaid Princess (Valkyrie Crusade)

Delphinus (Valkyrie Crusade) is a dolphin mermaid.

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Merfolk Physiology | Superpower Wiki | Fandom powered by Wikia

Music, Music Therapy and Neuroscience: Imagining Improvised and … – HuffPost

Imagine Imagine a dinner party where a renowned opera singer (soprano Rene Fleming, who also happens to be an Artistic Advisor at Large for the Kennedy Center) and a doctor (Francis Collins, the Director of the National Institutes of Health, also a guitarist, singer and composer) meet. One thing leads to another and they find themselves singing with the guests, three of whom are Supreme Court Justices, no less. They hatch a plan to have their institutions collaborate on music and the brain to amplify the work being done in this field.

Their collaboration builds upon community outreach efforts of the National Symphony Orchestra, including performances at the NIH Clinical Center over the past several years, broadens the scope and brings together the diverse artistic resources of the Kennedy Center with the scientific, clinical, and research expertise of the NIH.

Imagine Imagine the past, when a nurse named Florence Nightingale noticed that music comforted the solders for whom she was caring (in the 1800s), when the first degree program for music therapists began (1944), and when the first professional music therapy association began (1950). Fast forward to the more recent past when music therapy leaders gained unprecedented participation in the US Special Committee on Aging hearing, Forever Young: Music and Aging (1991) and when several expert music therapists were honored to guest lecture at the Library of Congress (2011)!

The big event has arrived. It is June 2-3, 2017.

Imagine Imagine the present, with concert halls and theaters full of musicians, neuroscientists, music therapists, researchers, clients, their family members, general patrons and lovers of the arts, and more.

Imagine leading neuroscientists onstage with the National Symphony Orchestra. Dr. Daniel Levitin explains that the brain is a pattern detector and music is full of patterns and motifs. We count how many times we hear the major third theme (short, short, short, long) in the first movement of Beethovens 5th Symphony.

Dr. Charles Limb shows us fMRI images (a neuroimaging technique) of Rene Flemings brain while she is singing and imagining singing The Water Is Wide. We learn that more parts of the brain are activated when singing or imagining one is singing than when speaking!

Dr. Levitin elaborates on why music matters. He refers to oxytocin as the social salience chemical, remarking that more oxytocin is produced when we listen and/or play collectively. In fact, a review by Inga Neumann states that oxytocin's impact on "pro-social behaviors" and emotional responses contributes to relaxation, trust and psychological stability.

Imagine Imagine the present, where over 7,000 Board Certified MusicTherapists blend art and science, develop therapeutic relationships, and systematically deliver music experiences to promote recovery, resilience, and enhanced quality of life, to name only a few positive outcomes, and music therapy researchers are adding to our 70-year evidence base to demonstrate the efficacy and effectiveness of our interventions.

In a coma following a snowboarding accident, Forrest Allens first response to music came in his second music therapy session with music therapist Tom Sweitzer, when he moved his pinky. After 29 surgeries and a few years of music therapy, he is now able to sing, speak, dance, and isolate his fingers to play the guitar. He powerfully exclaims that Music therapy saved my life! Producer Susan Koch has made a documentary titled, Music Got Me Here, about his experiences.

Bridging clinical music therapy and research, Dr. Wendy Magee cites a 2017 Cochrane Review on music for acquired brain injury to support Forrests amazing progress. She says, Music has a hotline to emotion and motivationWhat we hear influences how we move Music changes brain structure after neurological damage.

Jordan Cochran bravely tells his sons story. Born 8 weeks premature, Joshua was later diagnosed with autism and observed to avoid many sensory experiences, particularly those having to do with his hands. He was, and continues to be, extremely musical. CJ Shiloh, his music therapist, reveals how she systematically desensitized Josh and provided affirmation of his progress. She focused on areas such as use of his hands to play instruments, coping skills, communication and quality of life.

Dr. Blythe Lagasse outlines music therapy research supporting clinical applications for individuals with autism. Music therapy assists in social engagement, social interaction, joint attention, parent child relationships, communication skills, social emotional reciprocity, self-regulation, and attention!

Dr. Deforia Lane provides stirring examples of music therapy in medical settings: Through therapeutic singing, a gentleman vocalizes This Little Light of Mine after a stroke. A young man with sickle cell anemia creates a rap with his music therapist, facilitating appropriate expression of feelings. Dr. Lane emphasizes that a song can be a connecting point for anyone, any time, any place. Indeed, Dr. Sheri Robb works with teens and young adults undergoing stem cell transplants to create therapeutic music videos to promote positive coping skills and build resiliency. She and her team tailor music experiences to reduce stressful environments and develop more supportive environments.

Imagine Imagine the audience improvising on the spot, weaving these music therapy stories together with Ben Folds, a gifted musician, composer, educator, and advocate for music education and music therapy.

Now dare to imagine the future At the June 2nd concert, Jussie Smollett performed John Lennons song Imagine. The next afternoon Ben Folds performed his song You Are Capable of Anything during the panel on Music Therapy Breakthroughs. These performers, together with numerous other speakers, have inspired us.

Saturday afternoon Dr. Francis Collins and 19th US Surgeon General Vice Admiral Vivek Murthy, MD, MBA, brainstormed about what we can learn from studying musics interaction with the brain and what potential implications might be for music therapy.

Dr. Murthy spoke very eloquently: We are a country that has tremendous potential, but are being held back by pain. I'm not talking just about physical pain; I'm talking about a deeper, emotional pain...I recognized pretty quicklythere are some places that medicines cannot reach. There are parts of us that cant be accessed with traditional therapies. We need a different tool to get there. We need a different language... What is so beautiful about music is that music is a different language. It has a power to reach people in deep places where sometimes speech, or even touch, cant. He continued, The goal should not be to just be free of mental illness but to be at a peak state of emotional well being We have to include music and the arts in our toolbox for working toward improved emotional wellbeing of our country We need to create a nation that is as good at prevention as at treating illness.

Imagine-thats our motif. Through this historical new partnership, let us continue to imagine and work together In this vein, Dr. Francis Collins and Rene Fleming described their Sound Health: Music and the Mind initiative in a recent Journal of the American Medical Association article. They noted, Music therapists have generated evidence for the therapeutic effects of active engagement with music for an ever-growing list of indications. Future goals are now to connect the effects of music on the brain with mechanistic insights from biomarkers and other approaches to better understand how music therapy interventions may be working and enhance their efficacy and generalizability.

To learn more or to listen/watch to all the workshops presented on June 3rd, click here.

Magee, W. L., ,Clark, I.,Tamplin, J., & Bradt, J. (2017). Music interventions for acquired brain injury. Cochrane Database of Systematic Reviews, 2017 (1), 20;1. doi: 10.1002/14651858.CD006787.pub3.

Neumann, I. D. (2008). Brain oxytocin: A key regulator of emotional and social behaviors in both females and males. Journal of Neuroendocrinology. 2008 June; 20 (6): 858-65.

Start your workday the right way with the news that matters most.

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Music, Music Therapy and Neuroscience: Imagining Improvised and ... - HuffPost

Sky Watch: The case of the wandering ‘stars’ – TwinCities.com-Pioneer Press

Last month, I told you about the zodiac band that runs through the night sky. Because the Earth and the planets all orbit the sun in nearly the same plane, all of our fellow planets are located within it.

Back in the day, folks didnt know about any of this and saw the planets as wandering stars. In fact, they really didnt know what stars were, period. Most cultures saw them as being of a divine or godly nature. They saw patterns or pictures in the stars, which we call constellations, and observed them as they majestically slide from east to west night after night. Their predictable seasonal cycles through hundreds of years acted as clocks and calendars that helped them plan their lives. They were and still are infallibly reliable.

But then, as now, there were five stars that were mavericks or wild cards. Without a lot of rhyme or reason, they showed up every night in slightly different positions among the fixed stars. They would also switch directions and get brighter and fainter. Some of them even sported variations in color. They would also disappear from the skies for weeks at a time. Many cultures, including First Nation and Native Americans, saw them as greater gods and their motions and behaviors were signs of pleasure or displeasure with the mere mortals on the ground. Human behavior was controlled by these wandering stars.To appease them, sacrifices took place, sometimes even human ones.

Ancient Greeks referred to these independently minded wandering stars as asteres planets, which is where we get the term planets. The Greeks, as well as the neighboring Romans, didnt see these planets as gods themselves, but named them after major gods in their mythology out of respect for their deity. It never hurt to kiss up! The Roman names of the planets have carried on to thepresent day.

The planet Mercury is named after the messenger of the gods because of its speed among the stars, just as the god Mercury was considered the first speedy delivery service. It only takes Mercury 88 days to circle the sun, flying along at more than 100,000 mph.Earth plows along at just 67,000 mph.

Venus is named after the Roman goddess of beauty and love because of its great brilliance in the sky. Little did they know what a hellholethe planet is. Because of a thick poisonous atmosphere complete with acid rain, the runaway greenhouse leaves the surface temperature hot enough to melt lead. Its definitely not a beautiful place.

Because the planet Jupiter is so bright and stays in one place among the stars for a lot longer than Venus, it was named in honor of the king of the Roman gods. TheRomans were right in naming the planetafter their head god, Jupiter, because its by far the largest planet in the solar system at 88,000 miles in diameter. The Romans didnt know that at the time, of course.

The planet Saturn was named after the Roman god of agriculture for reasons that arent all that clear. However, Saturn was also considered the goddess of time because it takes so long for Saturn to make a complete circuit among the stars. Saturn takes more than 29 years to make that journey, the longest of all the planets.

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Sky Watch: The case of the wandering 'stars' - TwinCities.com-Pioneer Press

Genetics / Genomics SciPol Daily, 9 June 2017 | SciPol

Clinical OMICs Jackson Laboratory Expands Genomic Research Into China

The Jackson Laboratory (JAX) said it will expand into China through a strategic collaborative clinical genomics research agreement with three groups in Wenzhou. JAX will collaborate with the Wenzhou Municipal People's Government, Ouhai District People's Government (WZ), and Wenzhou Medical University and its affiliated hospitals (WMU), to conduct research on the genomic causes of disease.

Medical Xpress Stem cell treatment for lethal STAT1 gene mutation produces mixed results

Researchers report the first-ever study assessing how patients with "gain of function" mutation of the STAT1 gene respond to stem cell transplantation. It involved 15 young patients from nine different countries, each suffering a range of complications caused by the gene's mutation. Of these, only six survived a regime of stem cell transplantationwith five completely cured and disease free by the study's conclusion.

Motherboard CRISPR Is Not Accurate Enough to Save Us Yet

While this study brings some CRISPR limitations to the forefront, all of its claims may not stand up under scrutiny. We're definitely going to need more research to really figure out the extent of off-target mutations, when they happen, and why.

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Genetics / Genomics SciPol Daily, 9 June 2017 | SciPol

Rethinking the 14 day rule – BioEdge

Policy analysts in the United States and UK are calling for a reconsideration of the decades-old 14-day embryo experimentation rule - a regulation that requires scientists to terminate any embryo in vitro before it reaches two weeks of development. New embryology research indicates that scientists can now grow embryos in a culture dish well past 14 days, permitting research into early human development and various diseases.

An article in this months Hastings Center Report calls for a new public discussion of the longstanding regulation, suggesting in particular that we take into account new scientific and social perspectives on embryo research. ...our understandings of responsible research have evolved to require greater public participation in decisions about science, writes University of Edinburgh bioethicist Sarah Chan. Broader public discourse must begin now.

Chan says that the 14-day rule was originally based on an arbitrary compromise between different viewpoints on the moral status of the embryo. We should be open to considering whether the public now wants to extend or restrict the limits we place on embryo research.

Baroness Mary Warnock, a moral philosopher and one of the original proponents of the rule, has cautioned against change. According to Warnock, the rule provides a way of allowing for embryo research, while still addressing slippery slope concerns: you cannot successfully block a slippery slope except by a fixed and invariable obstacle, which is what the 14-day rule provided.

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Rethinking the 14 day rule - BioEdge

I had a ‘test-tube baby.’ Did I have to worry about health problems for … – Washington Post

By Amy Klein By Amy Klein June 10 at 8:00 AM

When I first visited a fertility doctor because of pregnancy problems, I had no idea that the in vitro fertilization, or IVF, he was suggesting to help me was actually the test-tube baby technique that Id heard about, an approach that had sounded scary, like something out of science fiction.

After I educated myself and started treatment, the concerns continued: Would the hormone-stimulating drugs have adverse effects on me? What would the drugs do to the fetus? And more important, would conceiving a child outside the womb (not actually in a test tube but in an embryology lab) have any long-term effects? Most important, would my child if I would be lucky enough to give birth to one be as physically and mentally healthy as naturally conceived children?

Articles and blogs fed into my worries not to mention the online mommy boards at pregnancy and fertility websites where women trade rumors, innuendoes and fears, often based on nothing more than a friends experience.

Since the first test-tube baby, Louise Brown, was born in England in 1978, about 6.5 million children have been born worldwide with the help of assisted reproductive technologies (ART) such as IVF. So there is now enough information to address my concerns. Overall, those findings leave me pretty confident that the risks are pretty small and well worth taking if, like me, you want to have a baby but cant.

Although taking fertility medications drove me crazy some hormones gave me nightmares, others kept me up at night, and the main ones made my mind race loopily looking at studies allowed me to conclude that IVF probably has no long-term bad effects.

For instance, a 2013 study of 21,646 women in Australia concluded that there is no evidence of an increased risk of ovarian cancer following IVF in women who give birth. Another study of 9,825 American women found no link between gonadotropins the drugs I was taking to increase my egg production and ovarian cancer for women who gave birth. There was one worrisome point: Both studies found an increased cancer risk for women with resistant infertility i.e., those who did not give birth although the researchers did not know why.

A recent study in the journal JAMA of about 25,000 women who had fertility treatments between 1980 and 1995 found that those who had gone through IVF had no greater risk of getting breast cancer in the subsequent 21 years than those who used other techniques.

Whew. I went through nine rounds of IVF before I got pregnant, which means I took a lot of ovary-stimulating drugs, so these studies are reassuring.

Numerous studies and opinions from [the American Society for Reproductive Medicine] confirm low risk for ovarian and breast cancer from the use of fertility drugs, regardless of the number of IVF cycles performed, said Jeffrey Braverman, founder and medical director at Braverman IVF & Reproductive Immunology in New York.

So how about risks to the baby? Would he or she be affected by her medically assisted conception?

Two studies have raised concerns.

A 2016 study in JAMA Pediatrics found increased risk for birth defects in babies conceived through ART. The study, which involved more than 4 million infants, found that singleton infants conceived using ART were 40 percent more likely to have a nonchromosomal birth defect (such as cleft lip and/or palate or a congenital heart defect) compared with all other singleton births.

The researchers acknowledged that the study did not account for some factors related to infertility that might explain the observed increases in risk for birth defects. In other words, IVF may not have caused the defects. They recommended further research.

A comprehensive review of a group of other studies suggested that the risk for developmental disabilities was greater with ART which, in addition to IVF, includes egg freezing and surrogacy than with natural childbirth. The review examined studies of IVF and autism, cerebral palsy, intellectual disability, attention-deficit/hyperactivity disorder and sensory impairment, among others, and found conflicting information, no correlation or that the disabilities could have been caused by other factors such as preterm birth.

And a study published in March found an increased risk of neoplasms tumors that can be benign or malignant in children born through ART.

But I focused on a study that followed children conceived with ART into their teenage years. It offers a much more reassuring view. The study, published in January, compared 253 16- and 17-year-olds who were conceived with fertility treatments to a cohort of teenagers conceived naturally and found that no differences were detected in general and mental health of ART adolescents or cognitive ability, compared with the reference group. The researchers, who said this was the first long-term study of such children, concluded that their preliminary results provide reassurance that in the long run, health and functioning of ART-conceived adolescents is not compromised.

One of the researchers on the study, Mark Weiser, a psychiatry professor at Tel Aviv Universitys Sackler School of Medicine, said in an interview that the findings should be a relief to parents who used IVF and other assisted reproductive technology. We show there is nothing wrong with these kids when compared with children born naturally. This is a very positive message to parents who are not able to get pregnant on their own. If you look down the line, the kids are perfectly normal.

As for me: After an uneventful pregnancy, my daughter was born full term nearly two years ago at a healthy six pounds, six ounces, with all her fingers and toes and brown hair that would soon turn to curls. She is a delightful, chatty, feisty toddler. Every parent worries about their child, and I know that I will be no different. But for now it seems clear to me that the risks of having used IVF were minimal and the reward huge.

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I had a 'test-tube baby.' Did I have to worry about health problems for ... - Washington Post