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FDA padlocks any new human tests on Seattle Genetics’ cancer drug in the wake of more deaths – Endpoints News

Clay Siegall, CEO, Seattle Genetics

In the wake of Seattle Genetics announcement that a disturbing tilt in deaths pointed to a likely safety problem for its late-stage cancer drug vadastuximab talirine (SGN-CD33A), the FDA has stepped in to yank the IND and officially put any human testing on hold.

The biotech $SGEN reported the FDAs move in a filing with the SEC this morning.

Seattle Genetics had already hit the brakes on its R&D work on the drug three days ago, scrapping the Phase III for acute myeloid leukemia and ordering a halt to any other testing until they can get a better read on the situation. It will also have to convince regulators that the drug is safe for testing after the FDA had lifted its first clinical hold on the drug just three months ago. That first hold on its early-stage work came after four patients died.

Those deaths were linked to liver toxicity, a classic red flag on safety. But this time one of the few clues provided by Seattle Genetics is that liver toxicity did not appear to be behind the disturbing rate of deaths investigators were seeing.

Back in March the biotech reported that it was getting restarted on the clinical work after it came up with revised eligibility criteria and stopping rules for veno-occlusive disease.The FDA agreed to lift the hold only two months after it was dropped on Seattle Genetics.

With its big Immunomedics deal axed by activists and its lead clinical drug in big trouble, Seattle Genetics CEO Clay Siegall will come under heavier pressure to diversify beyond Adcetris.

News reports for those who discover, develop, and market drugs. Join 16,000+ biopharma pros who read Endpoints News articles by email every day. Free subscription.

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FDA padlocks any new human tests on Seattle Genetics' cancer drug in the wake of more deaths - Endpoints News

Cells in fish’s spinal discs repair themselves – Phys.Org

June 22, 2017 In this developing backbone of a zebrafish, collapsed inner cells (green) are replaced by newly fluid-filled sheath cells (red) from the outer layer. The remaining cellular debris clumps together in the center of the structure, which is called a notochord. Credit: Jennifer Bagwell, Duke University

Duke researchers have discovered a unique repair mechanism in the developing backbone of zebrafish that could give insight into why spinal discs of longer-lived organisms like humans degenerate with age.

The repair mechanism apparently protects the fluid-filled cells of the notochord, the precursor of the spine, from mechanical stress as a young fish begins swimming. Notochord cells go on to form the gelatinous center of intervertebral discs, the flat, round cushions wedged between each vertebrae that act as shock absorbers for the spine.

The disappearance of these cells over time is associated with degenerative disc disease, a major cause of human pain and disability worldwide.

"It is not difficult to speculate that these same mechanisms of repair and regeneration are present in humans at very early stages, but are lost over time," said Michel Bagnat, Ph.D., senior author of the study and assistant professor of cell biology at Duke University School of Medicine. "If we are going to think about techniques that foster intervertebral disc regeneration, this is the basic biology we need to understand."

The study appears June 22, 2017, in Current Biology.

Bagnat likens the notochord to a garden hose filled with water. The hardy structure consists of a sheath of epithelial cells surrounding a collection of giant fluid-filled or "vacuolated" cells. During development, these vacuolated cells rarely pop, despite being under constant mechanical stress. Recent research has suggested that tiny pouches known as caveolae (Latin for "little caves") that form in the plasma membrane of these cells can provide a buffer against stretching or swelling.

To see whether the caveolae protected vacuoles from bursting, his team and collaborators from Germany generated mutants of three caveolar genes in their model organism, the zebrafish. Because these small aquarium fish are transparent as embryos, the scientists could easily visualize any spinal defects triggered by the loss of caveolae.

The researchers found that when the mutant embryos hatched and started swimming, exerting pressure on their underdeveloped backbones, their vacuolated cells started to break up. While the finding confirmed their suspicions, it turned up a puzzling discovery. "In the caveolar mutants, you see these serial lesions up and down the notochord, and yet the mature spine formed normally," said Bagnat. "That was very puzzling to us."

To figure out how that was possible, lead authors Jamie Garcia and Jennifer Bagwell took a closer look at the notochord of mutant fish. They marked the vacuolated cells green and the surrounding epithelial sheath cells red and then filmed the fish shortly after they hatched and started swimming. First, they could see an occasional vacuolated cell break and spill its contents like a water balloon. Then, over the course of fifteen hours, a nearby epithelial sheath cell would move in, crawl over the detritus of the collapsed cell, and morph into a new vacuolated cell.

They performed a few more experiments and found that the repair response was triggered by the release of the cell contents, specifically the basic molecular building blocks known as nucleotides. The researchers then isolated live epithelial sheath cells and treated them with nucleotide analogs to show that they turned into vacuolated cells.

"These cells, which reside in the discs of both zebrafish and man, seem capable of controlling their own repair and regeneration," said Bagnat. "Perhaps it is a continuous release of nucleotides that is important for keeping the disc in good shape."

The study may offer insight not only into the development of back and neck pain, but also into the origins of cancer. Their data suggests that chordomas, rare and aggressive notochord cell tumors, may begin when epithelial sheath cells leave the notochord and invade the skull and other tissues.

Explore further: Stem cells therapy for naturally occurring intervertebral disc disease

More information: "Sheath cell invasion and trans-differentiation repair mechanical damage caused by loss of caveolae in the zebrafish notochord," Jamie Garcia, Jennifer Bagwell, Brian Njaine, James Norman, Daniel S. Levic, Susan Wopat, Sara E. Miller, Xiaojing Liu, Jason W. Locasale, Didier Y.R. Stainier and Michel Bagnat. Current Biology, June 22, 2017. DOI: 10.1016/j.cub.2017.05.035

Journal reference: Current Biology

Provided by: Duke University

The intervertebral disc is the "shock absorber" between the vertebrae of the spine, cushioning every step, bend and jump. If the fibrocartilage tissue in the spine degenerates over time, an intervertebral disc can "slip" ...

Regeneration is an inherent property of life. However, the potential to regenerate differs across species: while fish and amphibians can re-grow appendages such as limbs, tails, and fins, mammals, including humans, cannot ...

A new study by basic science researchers in the Department of Basic Science and Craniofacial Biology at New York University College of Dentistry (NYUCD) sought to understand how gene expression is initiated in the notochord, ...

All cells are confronted with DNA damage, for example by exposure of the skin to UV rays, chemical byproducts of nerve cells consuming sugar, or immune cells destroying bacteria. If these DNA lesions are not - or badly - ...

Thoughts of the family tree may not be uppermost in the mind of a person suffering from a slipped disc, but those spinal discs provide a window into our evolutionary past. They are remnants of the first vertebrate skeleton, ...

Orthopedic researchers at Jefferson Medical College have for the first time found stem cells in the intervertebral discs of the human spine, suggesting that such cells might someday be used to help repair degenerating discs ...

The evolution of the amniotic eggcomplete with membrane and shellwas key to vertebrates leaving the oceans and colonizing the land and air. Now, 360 million years later, bird eggs come in all shapes and sizes, from ...

(Phys.org)A team of researchers with the EcoHealth Alliance has narrowed down the list of animal species that may harbor viruses likely to jump to humans. In their paper published in the journal Nature, the group outlines ...

Amid the incredible diversity of living things on our planet, there is a common theme. Organisms need to acquire new genes, or change the functions of existing genes, in order to adapt and survive.

Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle's protein shell.

Honeybees may not need key brain structures known as mushroom bodies in order to learn complex associations between odors and rewards, according to new research published in PLOS Computational Biology.

Duke researchers have discovered a unique repair mechanism in the developing backbone of zebrafish that could give insight into why spinal discs of longer-lived organisms like humans degenerate with age.

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A century of women in medicine at Yale – Yale News

June 21, 2017

Photo credit: Robert Lisak

By Natasha Strydhorst

In 1916, more than 100 years after its founding, the Yale School of Medicine admitted its first female students. At the time, this stood in marked contrast to the ethos of other institutions like Harvard, which considered it unladylike for women to attend medical school. By necessity, the three women admitted to the Class of 1916 were exceptionalunlike their male counterparts, who needed only two years of college education, they had to hold a college degree, and a quota further restricted the number of women admitted.

One of the three, Louise Farnam, held a Ph.D. in Physiological Chemistry from Yale. Although commonly known for her connection to the Louise Farnam memorial bathrooms (a donation from her father, an economics professor at Yale, made a womens lavatory possible, paving the way for female enrollment), Farnam was remarkable in her own right. Her story remains a source of inspiration to women in the medical field to this day.

In a talk in the Historical Library at this years reunion, Susan Baserga, M.D. 88, Ph.D. 88, FW 93, professor of molecular biophysics and biochemistry, of genetics and therapeutic radiology, recounted Farnams story as she traced the history of women at the School of Medicine. In 1978, while Baserga was an undergraduate at Yale College, her interest in the topic was sparked by a women in medicine course taught by Florence Haseltine, M.D., and Lisa Anderson, then-director of the Office for Women in Medicine. In this course, Mary Roth Walsh, Ph.D., a professor at the University of Lowell in Massachusetts spoke about barriers to women in medicine. In her talk, Roth Walsh noted an intriguing trend: more women practiced medicine before the turn of the 19th century than shortly thereafterwhen a college education, available almost exclusively to men, became essential to being a physician.

Women now comprise about 50 percent of enrolled students, 24 percent of professors, and two department chairs at the School of Medicine. While 5 percent of physicians in the United States in 1920 were women, that number is now 34 percent, according to the Kaiser Family Foundation.

When Farnam entered the medical school, her goal was to serve as a missionary to China. She graduated with highest honors alongside the honor of being selected as a commencement speaker. In 1921, she began her work in China at Yali (the College of Yale-in-China), the Changsha mission that opened in 1906. She further distinguished herself there, when, in 1930during the civil war between Nationalists and Communistsshe surrendered a spot on the evacuation vessel to tend a wounded soldier. I hate to go off and leave a man with a bullet in his chest liable to have pneumonia with no doctor on board. So I stayed, she wrote to her parents.

In the class following Farnams, only one woman was enrolled: Ella Wakeman. There was no fuss about this, Wakeman wrote, implying that this was because of her down-to-earth attitude, sensible clothing, and neatness. Reflecting on her lab partner, she wrote, It was probably a trial to him to have a partner in whose presence he had to behave.

Even as both medicine and the representation of women in the field have advanced markedly since the years of Farnams and Wakemans attendance at Yale, the underrepresentation of women in biomedical research remains a source of concern.

This article was submitted by Tiffany Penn on June 21, 2017.

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A century of women in medicine at Yale - Yale News

About last night: Anatomy of one of Phillies’ worst losses of 2017 – PhillyVoice.com

It wasnt all bad.

Really.

The last hour or so of Wednesday nights game surely was a series of unfortunate events. And well get to most of those in a minute, but, first, something good that actually came from one of the worst games of the season, a game that ended with the Phillies on the losing end for the 39th time in their last 50 games.

Nick Pivetta, the 24-year-old right-hander the Phillies once acquired for Jonathan Papelbon, is beginning to resemble the pitcher who dominated the competition in Triple-As International League in April. In his eighth career MLB start, Pivetta struck out a career-high 10 before walking a batter and took a 5-1 lead into the sixth inning.

After sporting a 5.12 ERA and allowing five home runs and an opponents 1.025 OPS in his first four starts, which earned him a trip back to Triple-A, Pivetta has a 3.91 ERA in his last four since returning to the Phillies, hes allowed just two homers and held the opponent to a .220/.304./.354 slash line.

Pivettas fastball was sitting at 94-MPH on Wednesday night and he was commanding it with the confidence of a veteran starter, not a kid that looked shell-shocked in May. Going to Allentown to work on his off-speed stuff helped, but so did reconnecting with his confidence, the mojo that can help a young pitcher take the important next step in their maturation.

As baseball players, you get into a rhythm, Ive gotten into a rhythm here and theres still stuff I can work on to help this team win more but I still put my team in a position to win, Pivetta said Wednesday night. Ive got more time here, got more confidence.

Pivetta is averaging 9.78 strikeouts-per-nine innings this season, which ranks second to the Angels Alex Meyer among rookies with at least 40 innings of work. Hes struck out 19 of the last 49 batters hes faced in his last two starts while walking just three batters in the same 13-inning span.

OK, now that thats done, onto the bad

It probably felt like a broken record last night for Phillies fans watching the bullpen blow the 5-3 lead Pivetta turned over to the relief corps.

Joaquin Benoit, one of the offseason moves that really hasnt panned out well for general manager Matt Klentak, served up a home run to the first batter he faced in the eighth inning, Cardinals pinch-hitter Jose Martinez, to make it a one-run game. Benoit has given up at least one run in three of his six appearances this month.

Hector Neris, one of baseballs best eighth-inning relievers in 2016, continued to be one of baseballs least trustworthy closers in 2017. He served up a game-tying homer to the second batter he faced in the ninth; Neris has served up five home runs in 13 save situations this season and opponents have a .879 OPS against him in save opportunities this season, compared to a .623 OPS in non-save opportunities. Perhaps its time to put him back in the eighth and let that be that.

But who should close? Pat Neshek makes a heck of a lot of sense, given his success this year. Yeah, he probably wont be here in a month as one of the teams two attractive trade deadline chips (along with Howie Kendrick) but that doesnt matter much now. Let him close until then.

Speaking of Neshek, there was a little confusion as to why he wasnt called on to pitch at all on Wednesday, when every other reliever that entered found a new way to turn a winnable game into a disaster. After the game, manager Pete Mackanin said Neshek was unavailable, as veteran relievers sometimes are through the course of a season.

He told me he couldnt pitch, Mackanin said. He was just sore.

According to Neshek, this isnt exactly true. Prior to the game, Neshek said Mackanin told him he was down, meaning he wouldnt be using him and instead would be giving the 36-year-old a day off after working in six of the previous 10 games (and warming up in another one of those contests but not entering, too).

Neshek may have asked for a day before Mackanin gave him the heads-up prior to the game but he may have also taken the ball if asked on Wednesday night, too.

One last bullpen note: its probably time to send Edubray Ramos to Triple-A.

Hes walked 20 batters and allowed 32 hits in 30 innings. Ramos 1.73 WHIP ranks 174th of the 189 major league relievers with at least 30 innings. Jeanmar Gomez, who was designated for assignment on Tuesday, was just ahead of him (173rd) with a 1.70 WHIP.

I dont know what to tell you, it looks like hes mixed up or something, Mackanin said of Ramos, who struck out 40 and walked 11 in 40 innings last year as a rookie. Hes not the same guy.

Despite being one of the Phillies few talented left-handed hitters capable of hitting anywhere toward the top of the lineup, Odubel Herrera was once ago promoted from a premier spot in Mackanins batting order to the sixth spot prior to Wednesdays game. Herrera had been leading off since Cesar Hernandez was placed on the DL, but his .291 OBP and 13 walks (fewer than every other regular whos been healthy all year) in 68 games are conducive of a leadoff hitter, of course.

Perhaps the lineup shift woke Herrera up. He went 2-for-5 with a double and a couple of RBI. Hes hitting third this afternoon.

But, yup, were burying the lede. In the bottom of the ninth, with the game tied, Herrera blatantly blew through third base coach Juan Samuels stop sign when Freddy Galvis doubled to left field.

Herrera was easily out by a few yards. Rally, over.

I was playing aggressive, Herrera said after the game through an interpreter. I wanted to win the game. So when I was rounding third, I put my head down. I kept going to home plate. Yeah, I saw (the stop sign). But I saw it late.

Samuel tried to physically place himself in front of Herrera as a last-second move after Herrera ignored him, to no avail. Samuel said it was the first time in his coaching career that a player ignored his stop sign at third.

I'm watching the plays in front of me, Samuel said. I put the brakes on, you've got to stop, whatever the situation is.

Herrera was one of the few bright spots on the Phillies roster in 2015 and 16, slashing .291/.353/.419 with 23 home runs, 51 doubles, and 41 stolen bases, and finishing as a finalist for the National League Gold Glove Award for center fielders last season. The 25-year-old has taken a major step back this season (.255/.291/.405, 13 walks, 68 strikeouts in 289 plate appearances).

The Phillies awarded Herrera with a five-year, $30.5 million contract this winter. It looked like a smart, team-friendly deal at the time, even getting it in place before Herrera was eligible for arbitration.

But now? Despite Herreras physical talent, he makes enough regular mental mistakes to make you wonder whether that was such a smart deal after all.

Follow Ryan on Twitter: @ryanlawrence21

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About last night: Anatomy of one of Phillies' worst losses of 2017 - PhillyVoice.com

Advanced Anatomy Classes at Broadway Bares’s Strip U | Out … – Out Magazine

Sunday at the Hammerstein Ballroom in midtown Manhattan, 181 of the hottest dancers in New York Citywith a roster of special guestsperformed with an absolute minimum of costuming. What could be more educational? The biggest seminar on the perfection of male and female dancer bodies was attended by eager students willing to toss large handfuls of crumpled tuition dollar bills at the nearly naked instructors, and it was all for a good cause! Broadway Bares Strip U raised $1.57 million for Broadway Cares/Equity Fights AIDS.

Want to meet some of the dancers? Check out their Instagram feeds.

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Advanced Anatomy Classes at Broadway Bares's Strip U | Out ... - Out Magazine

Kate Walsh Talks Playing ”Wicked Bitch” Addison Montgomery on … – E! Online

Kate Walsh will always have a bit of Addison Montgomery in her.

The actress rose to fame onGrey's Anatomystarring as the girl every avid watcher loved to hate. After two seasons as a main character opposite Ellen Pompeo andPatrick Dempsey, Walsh parlayed Addison into her own spinoff,Private Practice. Now four years after the hit medical drama said goodbye to the infamous neonatal surgeon, Walsh is reflecting on the role that changed her life.

During a Q&A with Buzzfeed, Kate said she'll never forget her entrance at the end of seasonone.Grey's fans will vividly remember when she (and her fiery red locks) surprised estranged husband Derek Shepherd (Dempsey) and his new girlfriend, Meredith Grey, (Pompeo) at the hospital. She recalled, "I got more calls and attention from that 60-second scene than anything in my career before.Isn't that funny?"

Walsh continued, "Everyone hated me, but at that time there was no Twitter. There were chat rooms, but I never really went on them. I kind of liked being the Wicked Witch from the East. Or the wicked bitch. [Show creator] Shonda [Rhime's] really gifted at flipping every character that's seemingly awful. It's a great lesson in how to have compassion for people that you initially hate."

ABC

The 13 Reasons Why staralso dished on-set secrets from the early days ofGrey's...long before the critical acclaim, sky-high ratings and Emmy awards.

Walsh explained, "With Grey's, I remember because I came in at episode 8, at that time the morale was really low. They kept changing the name of the show. It was Doctors and then Surgeons and then Complications and I was like, 'What a bullshit show title!' Grey's Anatomy is the perfect title."

"To keep our morale up they started showing us episodes at Friday lunches that were already edited," she revealed. "And I was like, 'This is a really good show' and I was so excited to be a part of it. I was supposed to do a pilot for another sitcom on ABC, and it didn't end up getting picked up and then they called me to be a series regular on Grey's and the world changed. It was stunning, right? It was really phenomenal."

With such fond memories, does Kate ever reminisce with aGrey's Anatomybinge-watching sesh? "I don't!" she admitted, "Once in a while I'll see a gif somewhere online. It would be really interesting to go back and watch nowthat would be really cool."

"It was funny, I was on The Today Show and I didn't know that Taye Diggs was guest-hosting and they showed a little clip of us when Sam and Addison were dating [on Private Practice] and I was like, 'Oh my god, who is that girl?' It's like watching someone else. I don't usually watch myselfI get a little freaked out. It's not good for me."

Walsh is evidently still a huge fan of the long-running series, and was just as shocked when producers killed off McDreamy in season 11. "Well, I was surprised when they killed off Patrick," she dished. "It had been so long and I was like, 'Oh, really?' And I tuned into that episode. It was like, 'Oh, I guess I should watch this.'

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Kate Walsh Talks Playing ''Wicked Bitch'' Addison Montgomery on ... - E! Online

CASIS and NCATS Announce Five Projects Selected from … – GlobeNewswire (press release)

June 21, 2017 12:00 ET | Source: Center for the Advancement of Science in Space

Kennedy Space Center, FL, June 21, 2017 (GLOBE NEWSWIRE) -- The Center for the Advancement of Science in Space (CASIS) and the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH), today announced five grants have been awarded in response to afunding opportunityfocused on human physiology and disease onboard the International Space Station (ISS) U.S. National Laboratory. Data from this research which will feature tissue chips (or organs-on-chips) will help scientists develop and advance novel technologies to improve human health here on Earth. These initial five projects are part of a four-year collaboration through which NCATS will provide two-years of initial funding of approximately $6 million, to use tissue chip technology for translational research onboard the ISS National Laboratory. Awardees will be eligible for a subsequent two years of funding, pending availability of funds, based upon performance and achieving milestones for each project.

The opportunity to partner with CASIS to perform tissue chip science on the International Space Station is a remarkable opportunity to understand disease and improve human health, said NCATS Director Christopher P. Austin, M.D. Physiological functions in the microgravity of the International Space Station will provide insights that will increase translational effectiveness on earth, including identifying novel targets for drug discovery and development.

The NCATS grants will support the following research projects:

Lung Host Defense in Microgravity

George Worthen, M.D. and Dan Huh, M.D, Childrens Hospital of Philadelphia (PA)

Implementation Partners: Space Technology and Advanced Research Systems (STaARS) and SpacePharma Inc

There is a link between infections and the health of our immune system. Infections are commonly reported onboard spacecraft where exposure to microgravity negatively affects immune system function, but the mechanisms responsible are not well understood. The goals of this project are to test engineered microphysiological systems that model the airway and bone marrow; and to combine the models to emulate and understand the integrated immune responses of the human respiratory system in microgravity.

Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain Barrier-Chip in Health and Disease

Christopher Hinojosa, M.S. and Katia Karalis, D.S., M.D, Emulate, Boston (MA)

Implementation Partner: SpaceTango

The objective of this project is to validate, optimize and further develop Emulates proprietary Organs-On-Chips technology platform for experimentation with human cells in space. The intent is to develop an automated platform and software to accelerate experimentation in space that will become available to the broader scientific community for studies in human physiology and disease in space. The scientific findings will provide new advancements for Earth studies in human disease and drug discovery. The Brain-Chip to be studied in microgravity is a prototype for an organ system centrally positioned in homeostasis and thus, involved in the pathogenesis of multiple types of disease including neurodegeneration, traumatic injury, and cancer.

Cartilage-Bone-Synovium Microphysiological System: Musculoskeletal Disease Biology in Space

Alan Grodzinsky, Sc.D., M.S and Murat Cirit, Ph.D., Massachusetts Institute of Technology, Cambridge (MA)

Implementation Partner: Techshot

This research focuses on a cartilage-bone-synovium joint tissue chip model to study the effects of space flight on musculoskeletal disease biology, motivated by post-traumatic osteoarthritis and bone loss. The effects of pharmacological agents to ameliorate bone and cartilage degeneration will be tested on earth and in the International Space Station, using a quantitative and high-content experimental and computational approach.

Microgravity as Model for Immunological Senescence and its Impact on Tissue Stem Cells and Regeneration

Sonja Schrepfer, M.D., Ph.D., Tobias Deuse, M.D., and Heath J. Mills, Ph.D., University of California, San Francisco (CA)

Implementation Partner: Space Technology Advanced Research Systems (STaARS)

Many space-related physiological changes resemble those observed during cellular aging, including defects in bone healing, loss of cardiovascular and neurological capacity, and altered immune function. This project aims to investigate the relationship between an individuals immune aging and healing outcomes, and to investigate the biology of aging from two directionsnot only during its development in microgravity conditions but also during recovery after return to earths environment.

Effects of Microgravity on the Structure and Function of Proximal and Distal Tubule Microphysiological System

Jonathan Himmelfarb, M.D., and Ed Kelly, M.S, Ph.D., University of Washington, Seattle (WA)

Implementation Partner: BioServe Space Technologies

When healthy, your two kidneys work together filter about 110 to 140 liters of blood to produce about 1 to 2 liters of urine every day. Dehydration or diseases like diabetes and high blood pressure impair kidney function and result in serious medical conditions including protein in the urine and kidney stones. Like osteoporosis, these conditions are even more common and follow an accelerated time-course in people living in microgravity. This project will send a kidney model to the International Space Station in order to understand how microgravity and other factors affect kidney function, and to use these discoveries to design better treatments for proteinuria, osteoporosis, and kidney stones on earth.

Our partnership with NCATS builds upon dramatic results fostered by public and private investment in organ-on-chip research and enables these pioneering researchers the opportunity to leverage the ISS National Laboratory to further advance an integral and burgeoning area of medical discovery to improve human health on Earth, said CASIS Deputy Chief Scientist Dr. Michael Roberts. Additionally, through these creative and collaborative partnerships with established granting agencies like the NCATS, the ISS National Lab demonstrates that research in microgravity is a viable setting to push beyond the terrestrial limits of scientific discovery and opportunity.

All grants and subsequent flight opportunities are contingent on final contract agreements between the award recipients, NCATS and CASIS.

For more information on the NCATS Tissue Chip for Drug Screening Program, including Tissue Chips in Space, please visit https://ncats.nih.gov/tissuechip.

To learn more about the on-orbit capabilities of the ISS National Lab, including past research initiatives and available facilities, visitwww.spacestationresearch.com.

# # #

About CASIS: The Center for Advancement of Science in Space (CASIS) is the non-profit organization selected to manage the ISS National Laboratory with a focus on enabling a new era of space research to improve life onEarth. In this innovative role, CASIS promotes and brokers a diverse range of research inlife sciences,physical sciences,remote sensing,technology development,andeducation.

Since 2011, the ISS National Lab portfolio has included hundreds of novel research projects spanning multiple scientific disciplines, all with the intention of benefitting life on Earth. Working together with NASA, CASIS aims to advance the nations leadership in commercial space, pursue groundbreaking science not possible on Earth, and leverage the space station to inspire the next generation.

About the ISS National Laboratory:In 2005, Congress designated the U.S. portion of the International Space Station as the nation's newest national laboratory to maximize its use for improving life on Earth, promoting collaboration among diverse users, and advancing STEM education. This unique laboratory environment is available for use by other U.S. government agencies and by academic and private institutions, providing access to the permanent microgravity setting, vantage point in low Earth orbit, and varied environments of space.

# # #

Attachments:

http://www.globenewswire.com/NewsRoom/AttachmentNg/87bf4685-0ff3-4650-98dc-6ba3709e125a

Attachments:

A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/4efb40f5-4081-428a-8548-9602bcb08511

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CASIS and NCATS Announce Five Projects Selected from ... - GlobeNewswire (press release)

Scholars debate free will in light of new neuroscience findings – Loma Linda University Health

Professor of Religion James Walters, PhD, left, and guest speaker Philip Clayton, PhD, took questions from the audience after Claytons plenary address during the conference Whats with Free Will? Ethics and Religion after Neuroscience.

Arms crossed in defiance. So reacted many of the audience members when Philip Clayton, PhD, stated his conviction that humans dont have complete free will. Noting this instinctual response of his listeners, Clayton said:

Half of you just crossed your arms over your chest, which is a biological signal that you think Im wrong.

For community members attending the conference Whats with Free Will? Ethics and Religion after Neuroscience on May 19-20, the topics complexity was revealed in the range of viewpoints argued by Clayton, of Claremont School of Theology, and the events other plenary speaker, Thomas Oord, PhD, of Northwest Nazarene University, as well as numerous other scholars during the smaller sessions.

Professor of Religion James Walters, PhD, of Loma Linda Universitys School of Religion, where he also directs its Humanities Program, organized the conference to consider the vast topic of free will, particularly in light of some new neuroscience findings that may suggest free will is just an illusion. That idea runs contrary to centuries of much Christian teaching that argues for free will as both a cornerstone of theodicy and a sign of Gods love for his creatures a love that does not allow Him to compel. The topic of free will is also crucial to fields such as law and ethics.

Clayton began his presentation by asking the audience members to clap their hands or blink, noting that they did so of their own free choice. Some refused to do it, also indicated their free choice right?

By and large, we just know were free, dont we? he asked, before spending the next hour arguing that most people dont have genuine freedom but that people may possess a psychological and spiritual freedom that, for most intents and purposes, is genuine.

Beginning with new findings of neuroscience and then discussing the increasing complexity of living organisms, from single-celled creatures to the great apes to humans, Clayton explained how both complexity and unpredictability increase, along with the ability to learn new behaviors.

But does that equal genuine free will? He argued no: humans are conditioned and bound by genetics, the workings of the brain, experience and education, to name a few to make the choices they do.

Was Nobel Laureate Francis Crick right? Are we nothing but a pack of neurons?

No, argued Clayton. He suggested a way to rise above pure determinism, via an asymptotic (for the mathematically inclined) or quasi type of freedom. He said that though humans cannot truly break free of every influence over them, according to scientific findings, they can choose a self-identity in which looking back and looking forward they own responsibility for their actions even if they werent taken freely.

In other words, humans transcend their lack of choice by creating personhood. And this allows humans to come into communion with what philosophy calls the ground of our being, which Clayton believes to be God. Having a relationship with Him.

This, Clayton said, is the answer we give to the universe.

Audience members heard a different perspective from Oord the next day. He opened his talk by asking the audience to imagine explaining the human experience via email to a being from a different galaxy.

Would free will be something to include that email? He argued yes of a limited variety. Despite what were told as children, we cannot actually be anything we want when we grow up. A person with no coordination cannot play the game like their favorite professional athlete, for example, he said. A blind person cannot choose to see.

But in general starting with what he called the most obvious reason Oord argued that our actions reveal our basic belief in freedom. He noted that if someone is punched, he or she will blame the aggressor.

Free will, Oord said, helps people make sense of other people and is necessary for the societal and religious concept of moral responsibility. Other items on his list of nine reasons we should affirm freedom included:

It shows us that our lives matter. It explains the desire to reject the old and embrace the new (change ones ways). It is most compatible to believing in a God who loves us. It explains our desire to learn.

This is an argument many would agree with. But Oord declared another, more controversial tenet: God, too, is limited.

Yes, Oord said: by the very nature of Gods being love He cannot act outside the desire for creaturely well-being.

This begs the question of why He doesnt then prevent suffering, Oord said.

God cannot prevent evil unilaterally, Oord said, backing up the statement by pointing to Bible verses that state limitations on Gods behavior. For example, 2 Timothy 2:13 says God cannot be unfaithful to his nature. Hebrews 6:18, among other verses, states God cannot lie.

But unable to stop wickedness? Part of His nature that Oord argued God cannot deny is to give life and give autonomy with it. And as an open theist, Oord believes God does not know the future and could not predict whether that freedom would mean creatures choosing sin and evil.

Following Oords presentation, a panel of some of the conferences scholars responded.

They were Kendal Boyd, PhD, MA, associate professor in LLU School of Behavioral Health; Calvin Thomsen, PhD, assistant professor in LLU School of Religion; Fritz Guy, PhD, author and research professor of philosophical theology at La Sierra University; David Larson, PhD, DMin, professor in LLU School of Religion; Richard Rice, PhD, professor in LLU School of Religion; Marlene Ferreras, MFT, doctoral student at Claremont School of Theology and associate professor of practical theology at La Sierra University; James Walters; Gerald Winslow, PhD, director of LLU Center for Christian Bioethics; Zane Yi, PhD, assistant professor at LLU School of Religion; Charles Scriven, PhD, author, pastor, former educator and chair of the Adventist Forum board; and Mark Ard, MD, MA, psychiatry resident at Loma Linda University Health. Most of them are members of the Seventh-day Adventist Church, which is the parent organization of Loma Linda University Health.

On the whole, Oords concept of human free will seemed to appeal more to most members of the panel than did Claytons. But there was some disagreement from the panel about Oords argument that Gods will is not completely free.

Winslow, for example, expressed discomfort with the idea that God has to give creatures free will. Rather, he said, God risked much in the service of love.

For her part, Ferreras agreed that God cannot exert complete control over humanity, but she said that He is able to act in the world for the good through the church.

Clayton was tasked with making a closing statement. He started by noting that he and Oord, with their two different ways of seeing, both have the same commitment to belief in a God of love.

And to understand Gods love, the best way to do so is to put it in terms of the greatest amount of love that humans can conceive of, Clayton said, which he believes is revealed through studying the nature of Jesus.

Clayton referred to the apostle Pauls letter to the Philippians, chapter 2:6-8, which says of Jesus:

Who, being in very nature God, did not consider equality with God something to be used to his own advantage; rather, he made himself nothing by taking the very nature of a servant, being made in human likeness.

And being found in appearance as a man, he humbled himself by becoming obedient to death even death on a cross!

Humans have the freedom to make a similar choice, Clayton said. A God who would voluntarily limit Godself so that we as puny human beings could rise, be free and enter into relationship with God, is the model for our own love, to voluntarily live in a sacrificial way for others.

Conference planner Walters said after the event, "I couldn't be more pleased with how the conference came together.The quality of the presentations was top-rate, the discussion significant and engaging, and the diversity of views broad. No one argued for a simple free will. A few argued that free will is more hope than reality, but the majority view was that humans possess genuine, but limited, free will."

Video of the conference can be viewed on the LLU School of Religion events video page.

Originally posted here:
Scholars debate free will in light of new neuroscience findings - Loma Linda University Health

Mountain lions fear humans, UC Santa Cruz study reveals – KSBW The Central Coast

SANTA CRUZ, Calif.

"Fraidy cat" isn't the way most people think of mountain lions, but when it comes to encounters with humans, perhaps they should.

New research into the behavior of these big cats indicates that they don't like encountering humans any more than we like bumping into them on hiking trails.

"We exposed pumas in the Santa Cruz mountains to the sound of human voices to see if they would react with fear and flee, and the results were striking: They were definitely afraid of humans," said Justine Smith.

WATCH: Mountain lion flees from sound of human voice

Smith was the lead author of the paper "Fear of the human 'super predator' reduces feeding time in large carnivores," published Wednesday.

The findings are valuable as human development encroaches on lion habitat and drives up the number of human-puma encounters.

The most recent cougar who wandered into a heavily populated neighborhood in Santa Cruz hid in a tree for hours until it was tranquilized and re-located into the mountains. The cougar appeared to be afraid during the April incident as more and more curious onlookers showed up.

READ MORE: Santa Cruz mountain lion found hiding in tree

Smith and her colleagues devised a novel experiment to gauge puma behavior: Her team placed audio equipment at puma kill sites in the Santa Cruz Mountains; when a puma came to feed, its movements triggered motion-activated technology that broadcast recordings of people talking, and a hidden camera captured the puma's responses.

They broadcast recordings of Pacific tree frog vocalizations as a control.

Human voice recordings were broadcast to mimic the natural volume of human conversation.

"We found that pumas almost always ran from the sound of humans--and almost never ran from the sound of frogs," said Smith, now a postdoctoral researcher at UC Berkeley. In 29 experiments involving 17 pumas, the pumas fled in 83 percent of cases as soon as it heard human voices, and only once upon hearing frogs.

READ MORE: Adorable wild mountain lion kittens found

National Park Service

In addition to establishing the fear response, the study reveals changes in puma feeding behavior that could have implications for their well-being in human-dominated landscapesand their impact on prey populations, particularly deer.

"We found that pumas took longer to return to their kills after hearing people, and subsequently reduced their feeding on kills by about half," said Smith. "Those behavioral changes are significant, as our previous work has shown that they cause pumas to increase their kill rates by 36 percent in areas with high human activity."

This is the first study to experimentally link the fear of humans to feeding behavior in large carnivores, said Chris Wilmers, associate professor of environmental studies at UC Santa Cruz and a senior author on the study.

"Fear is the mechanism behind an ecological cascade that goes from humans to pumas to increased puma predation on deer," said Wilmers, a wildlife ecologist who studies the cascading effects large carnivores can have on their prey. "We're seeing that human disturbancebeyond huntingmay alter the ecological role of large carnivores. As we encroach on lion habitat, our presence will likely affect the link between top predators and their prey."

The experiment was part of a long-term study of puma ecology in the Santa Cruz Mountains that began in 2008.

All 17 pumas in this study have housing developments in their home range, and exposure to humans is commonplace. Kill sites were identified with data transmitted from GPS-monitoring collars worn by pumas that have been captured, collared, and released as part of the project.

In addition to Smith and Wilmers, coauthors include Justin Suraci and Ayana Crawford at UC Santa Cruz, and Michael Clinchy, Devin Roberts, and Liana Zanette at Western University in Canada.

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Mountain lions fear humans, UC Santa Cruz study reveals - KSBW The Central Coast

FSU boardmember suggests women’s salaries may be lower due to genetics – WFLA

TALLAHASSEE, Fla. (CAPITOL NEWS SERVICE) A member of the Florida State University Board of Governors is in hot water, after making a comment at board meeting in which he seemed to suggest differences in starting salaries between men and women maybe genetic and not cultural.

The comment spurred a backlash.

Floridas Board of Governors was told that statistics show women graduates make less than their male counterparts a year after leaving school.

Board member Ed Morton suggested teaching salary negotiating skills for women, but also said the gap may be genetic. The women are given, maybe some of its genetic, I dont know. Im not smart enough to know the difference, he said.

Morton, who was appointed by Governor Rick Scott, was quickly condemned by the Governor in a statement issued by his press secretary.

As a father of two daughters, the Governor absolutely does not agree with this statement.

Morton has since apologized, issuing a statement, but refusing interviews. He says in part I chose my words poorly. My belief is that women and men should be valued equally in the workplace.

The controversy comes after legislation failed in the 2017 regular session that attempted to close the wage gap between men and women.

More women than men graduate from Florida universities, still womens median starting salaries are $5,500 less than men, said Jake Stofen.

Dr. Wayne Hochwarter a professorof Organizational Behavior at FSU says the gap is more likely a result of women choosing professions that pay less.

Whereas you still have a large section of young men who are also in the business school and engineering, he said.

Hockwarter also says research shows women often times are better prepared and better equipped for situations like negotiating salaries.

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FSU boardmember suggests women's salaries may be lower due to genetics - WFLA