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Genetics | CTCA

Cancer is triggered by mutations (changes) in the genes of a cell. These changes cause cells to reproduce in an unstructured, abnormal way. Most cancers occur by chance or sporadically. Gene changes may result from a random mistake when cells are dividing. Genes may also change in response to lifestyle habits and/or environment exposures or injuries.

A small portion of cancers have been identified as resulting from genetic changes that are inherited. Individuals with an inherited gene mutation tendency have an increased risk of developing cancer in their lifetime. However, not everyone who is born with a tendency for a gene mutation will develop cancer.

At Cancer Treatment Centers of America (CTCA) we offer genetic testing to help determine if your cancer was due to an inherited gene mutation and if you are at an increased risk of developing a second cancer.

Our Cancer Genetics Program consists of genetics education, counseling and testing services. You will learn about the role of genes and hereditary in the development of cancer and which of your family members may be affected. Before and after your test, you will meet with a genetic counselor to discuss your questions and concerns.

CTCA also offers genomic tumor assessment to help uncover genetic changes occurring within the tumor itself. Identifying these changes may help determine whats driving the growth of cancer. With this information, our physicians can better understand whats driving the growth of the cancer and find treatment options not previously considered.

The terms genetics and genomics may seem similar. Both refer to the genes in an individual. But genetics looks only at the traits you inherited from your parents, while genomics is focused exclusively on whats happening to the genes of an individual tumor.

Watch our video above to learn more about the difference.

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Genetics | CTCA

Interleukin Genetics slashes workforce, explores options – BioPharma Dive

Dive Brief:

Interleukin Genetics attempted to restructure its debts back in April, entering into a rejiggered agreement with Horizon Technology Finance which deferred the principal amount owed to the lender on April 1, May 1 and June 1. The deferral could have continued each month through September, but the borrower had to lock down by June 15 a "clinical services agreement" that had the approval of Horizon Technology Finance.

That didn't happen, and now Interleukin Genetics is doing whatever it can to gain capital.

"While this decision was extremely difficult, it is important to preserve capital as we assess our options," Interleukin Genetics CEO Mark Carbeau said in a July 3 statement. The company did not immediately respond to BioPharma Dive request for comment.

Interleukin Genetics also said in the statement it had about $925,000 in cash on hand as of June 30. Due to the strategic evaluation, its second quarter financial filings with the Securities and Exchange Commission will be coming in late.

Horizon Technology Finance initially loaned $5 million to the borrower back in late 2014. The parties agreed that Interleukin Genetics would repay the loan over 45 months, with the first 15 months being only interest payments and the latter 30 being equal payments of the total principal plus interest. The revamped agreement from earlier this year offered Interleukin Genetics a few months of deferred payments in exchange for an estimated 5.5 million to 11 million shares of the company's common stock.

Even if the borrower had secured a clinical services partnership and been able to keep the payment deferrals going a few more months, it has had trouble generating revenue.

Interleukin Genetics garnered nearly $200,000 in total revenue during the first quarter, down from almost $961,000 during the same period in 2016, which the company attributed to a decline in contracted research projects. A $2.3 million loss from operational costs led the company to have a net loss of $2.5 million for the first three months of 2017.

Moving forward, the company expects its main assets will be its Clinical Laboratory Improvement Amendments-certified testing and the intellectual property for its diagnostic programs, including Ilustra and the Inherent Health brand. It also expects the current restructuring efforts will cost $245,000.

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Interleukin Genetics slashes workforce, explores options - BioPharma Dive

How a few drops of blood led to a breakthrough in immunology – Medical Xpress

July 5, 2017 The image shows a lymph node in which we see normal T cells (in red) and Treg cells regulated by the FOXP3 gene (in green). Lymph nodes are small glands that are part of the lymph system which is important for body's defense system against diseases. Technique used: Confocal microscopy Credit: Ciriaco Piccirillo, Research Institute of the McGill University Health Centre

Scientists from the Research Institute of the McGill University Health Centre (RI-MUHC) may have cracked the code to understanding the function of special cells called regulatory T Cells. Treg cells, as they are often known, control and regulate our immune system to prevent excessive reactions. The findings, published in Science Immunology, could have a major impact in our understanding and treatment of all autoimmune diseases and most chronic inflammatory diseases such as arthritis, Crohn's disease as well as broader conditions such as asthma, allergies and cancer.

Researchers made this discovery by investigating a rare human mutation in a gene called FOXP3. Although the importance of the FOXP3 gene in the proper function of Treg cells has been well documented, its mechanisms were still not fully understood by scientists.

"We discovered that this mutation in the FOXP3 gene affects the Treg cell's ability to dampen the immune response, which results in the immune system overreacting and causing inflammation," explains the study's lead author, Dr. Ciriaco Piccirillo, immunologist and senior scientist in the Infectious Diseases and Immunity in the Global Health Program at the RI-MUHC, and a professor of Immunology at McGill University. "This discovery gives us key insights on how Treg cells are born and how they can be regulated."

Thanks to an international collaboration and cutting-edge technology from the Immunophenotyping Platform at the RI-MUHC, the team was able to make their discovery using only a few drops of blood from a five-week-old newborn boy who died in 2009 from a rare and often fatal inherited genetic immune disorder called IPEX. In the past 40 years, fewer than 200 cases of IPEX have been identified worldwide. Over 60 different mutations of the FOXP3 gene are known to cause IPEX and believed to result in non-functional Treg Cells.

"What was unique about this case of IPEX was that the patient's Treg cells were fully functional apart from one crucial element: its ability to shut down the inflammatory response," says Dr. Piccirillo.

"Understanding this specific mutation has allowed us to shed light on how many milder forms of chronic inflammatory diseases or autoimmune diseases could be linked to alterations in FOXP3 functions," adds the study's first author, Khalid Bin Dhuban, a postdoctoral fellow in Dr. Piccirillo's laboratory.

From fundamental biology to clinical treatment

Dr. Piccirillo and his colleagues have already developed a molecule that could restore the Treg cells' ability to control the immune system for patients with the same rare mutation. The drug has been tested in animal models and the researchers are hopeful they can also develop similar drugs that will apply for other conditions where Treg cells are known to be slightly defective such as arthritis, type I diabetes, multiple sclerosis and lupus.

"Currently, we have to shut down the whole immune system with aggressive suppressive therapies in various autoimmune and inflammatory diseases," explains Dr. Piccirillo. Our goal is to increase the activity of these Treg cells in certain settings, such as autoimmune diseases, but we want to turn it down in other settings, such as cancer. With this discovery, we are taking a big step in the right direction."

Dr. Ciriaco Piccirillo is also the director of the Centre of Excellence in Translational Immunology (CETI), a newly established research coalition based at the Research Institute of the MUHC that fosters linkages among biomedical investigators and clinicians for interdisciplinary immunology research focused on the understanding and treatment of immune-based diseases.

Explore further: Preventing too much immunity

More information: Suppression by human FOXP3+ regulatory T cells requires FOXP3-TIP60 interactions, Science Immunology 16 Jun 2017: Vol. 2, Issue 12, eaai9297 , DOI: 10.1126/sciimmunol.aai9297 , http://immunology.sciencemag.org/content/2/12/eaai9297

An immune-related protein deployed between neighboring cells in Drosophila plays an essential role in the cell degradation process known as autophagy, according to new research by Eric H. Baehrecke, PhD, at UMass Medical ...

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How a few drops of blood led to a breakthrough in immunology - Medical Xpress

Sun Pharma agrees manufacturing deal for immunology candidate – The Pharma Letter (registration)

India's largest drugmaker Sun Pharmaceutical has entered into a manufacturing agreement with South Koreas

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Sun Pharma agrees manufacturing deal for immunology candidate - The Pharma Letter (registration)

Neuroscience < University of Chicago Catalog

Contacts | Program of Study | Declaring the Major | General Education | The Major | Grading | Summary of Requirements for the Major in Neuroscience | Honors | Minor Options | Courses

Department Website: http://neuroscience.uchicago.edu/undergraduate

Neuroscience is the study of neurons and neural systems and their outputs: sensation, perception, homeostasis, and behavior. Neural function is investigated at the levels of molecules, cells, circuits, organisms, and species, making neuroscience inherently multidisciplinary. In addition to established neuroscience career paths in academia, medicine, and the pharmaceutical industry, new careers for students of neuroscience are emerging in economics, software development, and other fields requiring "big data" analysis or a mechanistic understanding of how humans think. The course of study in the undergraduate major in neuroscience provides students with the background and skills appropriate for these diverse careers.

The University of Chicago offers a bachelor of arts (BA) degree and a bachelor of science (BS) degree in Neuroscience. The Neuroscience major is designed to accommodate students with the range of scientific variety that one finds at the professional level of neuroscience, including physics, chemistry, computer science, engineering, mathematics, biology, psychology, and medicine. Neuroscience faculty at the University of Chicago have expertise in all of these areas and are distributed across the Biological Sciences, Social Sciences, and Physical Sciences Divisions. Majoring students have the opportunity to take a broad range of courses or to specialize in a particular area.

Students who wish to major in Neuroscience should declare the major in their second year.

(Because the Neuroscience major was introduced in the 201617 academic year, the Class of 2020 and subsequent classes can design a plan of study in Neuroscience from their first year. Students in the Classes of 2018 and 2019 may also be able to major in Neuroscience, depending on the courses they have already taken, although there is no way to guarantee this. Students in these classes should consult with their College advisers to see if majoring in Neuroscience is feasible.)

Students majoring in Neuroscience typically begin their general education requirement in the Biological Sciences with BIOS20186 Fundamentals of Cell and Molecular Biology. Attaining a proper grounding in cell biology is essential before delving into neuroscience as a discipline. To complete the requirement, students may choose to take one of the following: BIOS20150 How Can We Understand the Biosphere?, BIOS20151 Introduction to Quantitative Modeling in Biology (Basic), BIOS20152 Introduction to Quantitative Modeling in Biology (Advanced), BIOS20187 Fundamentals of Genetics, BIOS20188 Fundamentals of Physiology, or BIOS20191 Integrative Physiology. (Note: The general education requirement for the NSCI major can be fulfilled by courses in the Biology Fundamentals Sequences [20186-20190] without the Biological Sciences prerequisites [BIOS 20150-20151/20152] unless a student pursues a double major in Biological Sciences. Students who choose this path will be expected to possess the competency in mathematical modeling of biological phenomena covered in BIOS 20151 or BIOS 20152.)

Two alternative paths to fulfilling the General Education requirements exist. 1) Neuroscience majors may petition to take the Pre-Med Sequence for Non-Biology majors. In this case, BIOS20170 Microbial and Human Cell Biology and BIOS20171 Human Genetics and Developmental Biology will satisfy the core. (Note that BIOS 20171 must be taken concurrently with BIOS20172 Mathematical Modeling for Pre-Med Students .) 2) A score of 4 or 5 on the AP Biology exam allows students to enter the Advanced Biology sequence in the Autumn of their first year. This three-quarter, lab-intensive sequence is for students with a strong background in research. Upon completion of the sequence students are awarded two credits, which satisfy the general education requirement in Biological Sciences.

The basic degree in Neuroscience is the BA, for which requirements are described below. A BS is awarded to students who complete an additional three quarters of Neuroscience electives, which must include one to three quarters of faculty-supervised research (scholarly or experimental) resulting in a written thesis (see Requirements for the Bachelor of Science Degree in Neuroscience below).

The major curriculum includes nine required Neuroscience courses, which provide a comprehensive overview of the field. The BA requires another 700 units of elective courses, which must be selected from the list below. Electives can be chosen for a broad exposure or tailored for depth in a particular area, such as cellular/molecular, systems, cognitive, and computational neuroscience and machine learning.

Students must have their program of elective courses approved by the office of the director of undergraduate studies. The Student Elective Approval Form should be filled out by the end of the third year and submitted to the Neuroscience major director of undergraduate studies for approval at neuromajor@uchicago.edu.

While it is possible to complete a double major in Neuroscience and another program, this is not encouraged. Neuroscience majors are generally better suited to achieving breadth through a combination of courses that provides the desired expertise in neuroscience and carefully selected courses outside of neuroscience.

Students can earn a BS in Neuroscience by completing three quarters of Neuroscience elective courses over and above the BA requirements, which must include one to three quarters of faculty-supervised research that results in a written thesis (NSCI29100, NSCI29101, NSCI29102 Neuroscience Thesis Research). The additional courses and the thesis work require approval by the office of the director of undergraduate studies and the thesis advisor. The thesis may be either research-based or literature-based.

All courses used to satisfy prerequisites and requirements must be taken for quality grades. Students must pass all required courses with an average GPA of 2.0 or higher to continue in the program.

To obtain honors in Neuroscience, students must have a minimum cumulative GPA (3.25) at the point of entering the honors track, no later than the end of the third year. Entry into the honors track must be approved by the director of undergraduate studies. Students must do experimental research for three quarters and submit a thesis (NSCI29200, NSCI29201, NSCI29202 Neuroscience Honors Thesis Research). As part of the research course work, honors students participate in regular group meetings in which they share their research with each other and supervising faculty, and receive guidance on formulating testable hypotheses, experimental design, report writing, and oral presentations. They also receive training in the responsible conduct of research. Experimental research may not be credited toward honors in more than one major.

A minor in Neuroscience is not offered. The College offers a minor program in Computational Neuroscience, and students majoring in Biological Sciences have the option of completing a Specialization in Neuroscience.

NSCI00292. Neuroscience Honors Thesis Research. 100 Units.

Research Thesis and Seminar

Instructor(s): Elizabeth GroveTerms Offered: Summer Prerequisite(s): Acceptance into the Neuroscience Honors Program

NSCI20100. Neuroscience Laboratory. 100 Units.

This course has three components in series, representing (1) molecular neuroscience, (2) cellular electrophysiology, and (3) computation and psychophysics. The course meets one afternoon each week for four hours of laboratory time, including a didactic introduction. Students will be graded on their laboratory reports.

Instructor(s): J. Maunsell; E. Heckscher; C. Hansel; M. McNultyTerms Offered: Winter Note(s): This course will be offered in the 201718 academic year and each year thereafter.

NSCI20110. Fundamental Neuroscience. 100 Units.

This course is a rigorous introduction to the study of neurons, nervous systems and brains. The systems anatomy and physiology of the vertebrate brain will be covered in depth. Common features of neural circuits, such as those subserving the stretch reflex, will be examined. The biology of brain evolution and development will be introduced. A highlight of this course will be student dissections of sheep brains and the laboratory presentation of human brain dissections by the instructors.

Instructor(s): C. Ragsdale, P. Mason Terms Offered: Autumn Prerequisite(s): At least two quarters of Biological Sciences instruction (including courses taken concurrently) or consent of instructor. Equivalent Course(s): BIOS 24110

NSCI20120. Cellular Neuroscience. 100 Units.

This course describes the cellular and subcellular properties of neurons, including passive and active electrophysiological properties, and their synaptic interactions. Readings are assigned from a general neuroscience textbook.

Instructor(s): R. A. Eatock, W. Wei, StaffTerms Offered: Winter Prerequisite(s): NSCI 20110, along with completion of MATH 13100, or MATH 15100, or MATH 16100 Equivalent Course(s): BIOS 24120

NSCI20130. Systems Neurobiology. 100 Units.

This course covers vertebrate and invertebrate systems neuroscience with a focus on the anatomy, physiology, and development of sensory and motor control systems. The neural bases of form and motion perception, locomotion, memory, and other forms of neural plasticity are examined in detail. We also discuss clinical aspects of neurological disorders.

Instructor(s): D. Freedman, Staff Terms Offered: Spring Prerequisite(s): NSCI 20110, and NSCI 20120 or consent of instructor Equivalent Course(s): BIOS 24130

NSCI20140. Sensation and Perception. 100 Units.

What we see and hear depends on energy that enters the eyes and ears, but what we actually experienceperceptionfollows from human neural responses. This course focuses on visual and auditory phenomena, including basic percepts (for example, acuity, brightness, color, loudness, pitch) and also more complex percepts such as movement and object recognition. Biological underpinnings of perception are an integral part of the course.

Instructor(s): K. LedouxTerms Offered: Winter Equivalent Course(s): PSYC 20700

NSCI29100. Neuroscience Thesis Research. 100 Units.

Scholar or Research Thesis.

Instructor(s): StaffTerms Offered: Autumn,Spring,Summer,Winter Prerequisite(s): By consent of instructor and approval of major director.

NSCI29101. Neuroscience Thesis Research. 100 Units.

Scholar or Research Thesis.

Instructor(s): StaffTerms Offered: Autumn,Spring,Summer,Winter Prerequisite(s): NSCI 29100, and consent of instructor, and approval of major director.

NSCI29102. Neuroscience Thesis Research. 100 Units.

Scholar or Research Thesis.

Instructor(s): StaffTerms Offered: Autumn,Spring,Summer,Winter Prerequisite(s): NSCI 29100, and consent of instructor, and approval of major director.

NSCI29200. Neuroscience Honors Thesis Research. 100 Units.

Research Thesis and Seminar.

Instructor(s): StaffTerms Offered: Autumn,Spring,Summer,Winter Prerequisite(s): By consent of instructor and approval of major director. Open to Neuroscience majors who are candidates for honors in Neuroscience.

NSCI29201. Neuroscience Honors Thesis Research. 100 Units.

Research Thesis and Seminar.

Instructor(s): StaffTerms Offered: Autumn,Spring,Summer,Winter Prerequisite(s): NSCI 29200, and consent of instructor, and approval of major director. Open to Neuroscience majors who are candidates for honors in Neuroscience.

NSCI29202. Neuroscience Honors Thesis Research. 100 Units.

Research Thesis and Seminar.

Instructor(s): StaffTerms Offered: Autumn,Spring,Summer,Winter Prerequisite(s): NSCI 20201, and consent of instructor, and approval of major director. Open to Neuroscience majors who are candidates for honors in Neuroscience.

Link:
Neuroscience < University of Chicago Catalog

I Tried a Mindfulness App to Fight My App Addiction – Organic Authority

iStock/Georgijevic

Technology can be addictive. I got to a point where I felt like I needed to check my phone even though Id only checked it five minutes before.While I knew that didnt make sense, I still checked it. I was frustrated with myself. But what I didnt know was that the feeling I was having was well-designed and predictable. Tech companies pay for us to develop app addiction.

While Dopamine Labs typically designs apps to be addictive, the company also created an app called Space Because You Need a Breatherto combat app addiction. This past week, I gave it a shot and talked to Matt Mayberry, Dopamine Labs head of business development, about how Space works.

Dopamine Labs uses artificial intelligence and neuroscience to help tech companies design apps and software. Essentially, the goal is to make you want to use technology as often as possible. The API (an app-intelligence program) gives users the perfect burst of dopamine to keep them hooked, says Mayberry. Dopamine Labs co-founder Dr. Combs holds a PhD in neuroscience.

One example of how Dopamine Labs API works is Instagram likes. When you post a photo on Instagram, in reality, most of your likes come in at about the same time. But Instagram is designed to hold back likes. The app only shows them to you when youve been away from Instagram a while. This way, you keep coming back for more.

Its mischievous, says Mayberry, but its also brilliant.

One night, the team at Dopamine Labs began to discuss what it would be like if someone built an anti-dopamine. In other words, what would happen if the team built an app that stopped the addictive dopamine rush? What they came up with was Space Because You Need a Breather, an app that fights app addiction.

Space reverses the work Dopamine Labs typically does, re-wiring your instant gratification sensors to not go off every time you check an app. Anti-dopamine is simple: Instead of giving you instant gratification when you check an app, it makes you wait for a brief pause. Just this moment of waiting decreases the addictive effect of instant gratification you typically get when you see another flood of likes. In effect, instant gratification is being replaced with a moment of mindfulness.

When I got Space Because You Need a Breather, the app allowed me to choose certain apps or websites I wanted space from. I chose my email, Facebook, and Instagram. Then, every time I clicked one of those apps, a screen of deep space popped up and asked me to take 1 deep breath beforeI started.

Thats literally all the app does. It makes you wait a little longer than you typically would to use an app. Because youre forced to wait for one deep breath (sometimes more), your instant gratification sensors dont get the happy rush theyre used to. After using the app multiple times with this pause, you brain will stop expecting the instant gratification. As a result, ideally, youll begin to use the app less.

One thing I noticed is that, depending on how often I used an app, the breathing pause would become even longer. This is because artificial intelligence automatically adjusts the wait time, depending on how addicted you are to an app. The more you use an app, the longer it forces you to wait.

While the app hasnt made a drastic change in my thinking or feeling about my app use in just one week, I do feel less emotionally dependent on Instagram likes. Maybe part of this is knowing that a computer program is withholding likes from me, and that ultimately, the number doesnt matter.

According to Mayberry, Dopamine Labs is one of the few if not the only company using our technology for good. Its Dopamine Labs goal to help us modify our behavior in positive ways. Space was originally blocked from the Apple app store because Apple didnt want to sell anything that made people use their phones less. Then, as Mayberry puts it, Apple decided they wanted to be on the right side of history. Now, it offers the app Space.

Kicking app addiction can be hard and it makes sense, considering how much money goes into paying companies like Dopamine Labs to keep us hooked. On my laptop, I found myself changing tabs to go to different websites rather than breathing one breath with the app because I still needed that instant gratification. Hopefully, continuing to use Space and taking more moments of mindfulness will help me snap out of that. Ive found one new app addiction, but I think its a good one.

Space is available in Apple iOS,Android, and on Chrome as an extension.

Related on Organic AuthorityDo You Have a Smartphone Addiction?5 Ways High-Tech Gadgets Ruin Your Body5 Signs Your Exercise Addiction Might Make You Obsess Over Fitness Trackers and Nutrition Apps

Lauren Krouse is an autodidact, travel addict, amateur Buddhist philosopher, and proud black lab mama. She believes in sounding her barbaric yawp over the roofs of the world Whitman-style and is frequently found writing in the woods perched on a log or reading on the coast with her belly in the sand.

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I Tried a Mindfulness App to Fight My App Addiction - Organic Authority

Aytu BioScience Presents Clinical Findings for its MiOXSYS System at 33rd Annual Meeting of the European Society … – PR Newswire (press release)

Josh Disbrow, Chief Executive Officer of Aytu BioScience, stated, "These latest research findings continue to add to the clinical and scientific evidence supporting use of our MiOXSYS System, which we've already demonstrated to be a useful clinical tool for assessing oxidative stress levels in semen as it relates to male infertility. These seven presentations at ESHRE, presented by leading andrologists and urologists from infertility centers around the world, demonstrate the broad interest and significant potential for clinical use of the MiOXSYS System as an aid in the diagnosis of male factor infertility."

The poster presentations were as follows:

Title: ORP: A Reliable and Reproducible Method of Evaluating Oxidative Stress - A Multicenter Study Poster Number: G17-0526 Session: 36 Presenter: Ashok Agarwal, Ph.D., Director of the Andrology Center and Director of the American Center for Reproductive Medicine at the Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH Conclusion: Although other semen parameters showed significant differences between the two centers, sORP remained consistent in both data sets individually or in combined data. This proves its reproducibility and reliability. sORP is a measure of semen quality which adds more weight to semen testing in identifying fertile from infertile semen samples.

Title: Effect of Seminal ORP Value on Embryo Quality and Clinical Pregnancy Rate Poster Number: G17-1357 Session: Andrology Presenter: B. Balaban, VKF American Hospital Assisted Reproduction Unit stanbul, Turkey Conclusion: These findings may have important diagnostic and prognostic implications for couples experiencing male factor infertility and undergoing assisted reproductive technique (ART). Further studies are warranted to explore the mechanism of increased ORP in a subset of couples (male factor, no female factor) undergoing ART to corroborate the significance of these findings.

Title: Oxidation-Reduction Potential and Sperm DNA Fragmentation Levels in Sperm Morphologic Anomalies Poster Number: G17-0075 Session: 36 Presenter: A. Majzoub, Urology Department Hamad Medical Corporation, Doha, Qatar; Conclusion: Results were obtained from semen samples of patients presenting with primary or secondary infertility and hence were not compared with a control group or with men of proven fertility. Studying the correlation between sperm morphology indices and advanced sperm function tests is important as this would help in resting the controversy surrounding its clinical implication on fertility potential. It may also provide insights for developing novel sperm selection techniques that can be utilized during assisted reproduction.

Title: Oxidation-Reduction Potential: A Valuable Tool for Male Fertility Evaluation. Poster Number: G17-0182 Session: 4 Presenter: A. Majzoub, Urology Department Hamad Medical Corporation, Doha, Qatar; Conclusion: ORP measurement with the MiOXSYS System is a simple, quick and user friendly method that can reliably measure OS in biologic samples. The significant correlation between ORP and total motile sperm count allows its use as a predictor of fertility potential.

Title: High Levels of Seminal Oxidation-Reduction Potential (ORP) in Infertile Men with Clinical Varicocele Poster Number: G17-0995 Session: Andrology Presenter: R. Saleh, Director, Ajyal Hospital, Sohag, Egypt Conclusion: These findings may have important diagnostic and therapeutic implications. Further studies are warranted to explore the mechanism of increased ORP in a subset of infertile men with clinical varicocele. In addition, future studies may help determine those patients who would benefit from antioxidant therapy and/or surgical repair of varicocele.

Title: Oxidation-Reduction Potential Can Help Distinguish Semen Samples Under Oxidative Stress Poster Number: G17-0954 Session: Andrology Presenter: S. Roychoudhury, Assam University, Silchar, India Conclusion: Measuring sORP can help a clinician understand if comparatively one semen sample is under higher state of oxidative stress than another.

Title: Correlation of Sperm DNA fragmentation and Seminal Oxidation Reduction Potential in Infertile Men Poster Number: G17-0055 Session: Andrology Presenter: H. Elbardisi, Urology Department Hamad Medical Corporation, Doha, Qatar; Conclusion: Sperm DNA fragmentation and seminal oxidation reduction potential should be included in assessment of male infertility. Using ORP testing can help in detecting the target patients for antioxidant therapy.

Selection of the abstracts for publication in the press program does not imply endorsement of the MiOXSYS System by ESHRE.

About Aytu BioScience, Inc.

Aytu BioScience is a commercial-stage specialty pharmaceutical company focused on global commercialization of novel products in the field of urology, with a focus on products addressing vitality, sexual wellness, and reproductive health. The company currently markets two prescription products in the U.S.: Natesto, the first and only FDA-approved nasal formulation of testosterone for men with hypogonadism (low testosterone, or "Low T") and ProstaScint (capromab pendetide), the only FDA-approved imaging agent specific to prostate specific membrane antigen (PSMA) for prostate cancer detection and staging. Additionally, Aytu is developing MiOXSYS, a novel, rapid semen analysis system with the potential to become a standard of care for the diagnosis and management of male infertility caused by oxidative stress. MiOXSYS is commercialized outside the U.S. where it is a CE Marked, Health Canada cleared product, and Aytu is planning U.S.-based clinical trials in pursuit of 510k medical device clearance by the FDA. Aytu's strategy is to continue building its portfolio of revenue-generating products, leveraging its focused commercial team and expertise to build leading brands within growing markets. For more information visit aytubio.com. Aytu also now owns wholly-owned subsidiary Aytu Women's Health (formerly Nuelle, Inc.), a personal health and wellness company focused on women's sexual wellbeing and intimacy that markets Fiera, a personal care device for women that is scientifically proven to enhance physical arousal and sexual desire. Fiera is a consumer device and is not intended to treat, mitigate, or cure any disease or medical condition. For more information about the Fiera personal care device visit fiera.com.

Forward Looking Statement

This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, or the Exchange Act. All statements other than statements of historical facts contained in this presentation, including statements regarding our anticipated future clinical and regulatory events, future financial position, business strategy and plans and objectives of management for future operations, are forward-looking statements. Forward looking statements are generally written in the future tense and/or are preceded by words such as "may," "will," "should," "forecast," "could," "expect," "suggest," "believe," "estimate," "continue," "anticipate," "intend," "plan," or similar words, or the negatives of such terms or other variations on such terms or comparable terminology. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results to differ materially. These risks and uncertainties include, among others: risks relating to gaining market acceptance of our products, obtaining reimbursement by third-party payors, the potential future commercialization of our product candidates, the anticipated start dates, durations and completion dates, as well as the potential future results, of our ongoing and future clinical trials, the anticipated designs of our future clinical trials, anticipated future regulatory submissions and events, our anticipated future cash position and future events under our current and potential future collaborations. We also refer you to the risks described in "Risk Factors" in Part I, Item 1A of Aytu BioScience, Inc.'s Annual Report on Form 10-K and in the other reports and documents we file with the Securities and Exchange Commission from time to time.

Investor contact:

Amato and Partners, LLC

Investor Relations Counsel

admin@amatoandpartners.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/aytu-bioscience-presents-clinical-findings-for-its-mioxsys-system-at-33rd-annual-meeting-of-the-european-society-of-human-reproduction-and-embryology-300482828.html

SOURCE Aytu BioScience, Inc.

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Aytu BioScience Presents Clinical Findings for its MiOXSYS System at 33rd Annual Meeting of the European Society ... - PR Newswire (press release)

Artificial intelligence better than scientists at choosing successful IVF embryos – Independent Online

Scientists are using artificial intelligence (AI) to help predict which embryos will result in IVF success. In a new study, AI was found to be more accurate than embryologists at pinpointing which embryos had the potential to result in the birth of a healthy baby. Experts from Sao Paulo State University in Brazil teamed up with Boston Place Clinic in London to develop the technology in collaboration with Dr Cristina Hickman, scientific adviser to the British Fertility Society. They believe the inexpensive technique has the potential to transform care for patients and help women achieve pregnancy sooner. During the process, AI was "trained" in what a good embryo looks like from a series of images. AI is able to recognise and quantify 24 image characteristics of embryos that are invisible to the human eye. These include the size of the embryo, texture of the image and biological characteristics such as the number and homogeneity of cells. During the study, which used cattle embryos, 48 images were evaluated three times each by embryologists and by the AI system. The embryologists could not agree on their findings across the three images, but AI led to complete agreement. Stuart Lavery, director of the Boston Place Clinic, said the technology would not replace examining chromosomes in detail, which is thought to be a key factor in determining which embryos are "normal" or "abnormal". He said: "Looking at chromosomes does work, but it is expensive and it is invasive to the embryo. What we are looking for here is something that can be universal. Instead of a human looking at thousands of images, actually a piece of software looks at them and is capable of learning all the time. As we get data about which embryos produce a baby, that data will be fed back into the computer and the computer will learn. "What we have found is that the technique is much more consistent than an embryologist, it is more reliable. It can also look for things that the human eye can't see." He said work was under way to look back at images from parents who had genetic screening and became pregnant. Applying AI to those images will help the computer learn, he said. Mr Lavery added: "This is an innovative and exciting project combining state of the art embryology with new advances in computer modelling, all with the aim of selecting the best possible embryo for transfer to give all our patients the best possible chance of having a baby. Although further work is needed to optimise the technique, we hope that a system will be available shortly for use in a clinical setting."

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Artificial intelligence better than scientists at choosing successful IVF embryos - Independent Online

Anatomy Of A Love Triangle: Husband Kills Wife For Insurance Money And His Transgender Lover – Oxygen (blog)

February 23, 1991. Arizona businessman Dan Willoughby and his family were on vacation in Las Conchas, Mexico. Dans wife Trish stayed behind to take a nap, according to Snapped on Oxygen, while Dan and the kids spent the afternoon touring the coastal community. When Dan and his three children came back to the vacation home, the kids found their 43-year-old mom with her skull crushed and a butter knife sticking out of one of the fractures. She had been beaten and stabbed, and she was grasping for life. Not long after, she was dead.

Dan told Mexican police that over $400 in cash and two rings were missing from the scene. The crime scene appeared to be a robbery gone bad. This murder is the subject of this week's Martinis& Murder podcast.

The child of Mexican farm laborers, Yesenia Patino was 6 years old when her family immigrated to the United States in 1962. She hustled men in bars and on the streets, and she occasionally supplemented her income by shoplifting. She lived all over, but by the late 1980s, Yesenia moved to Mesa, Arizona, near her family. According to Yesenia, she and a friend were waiting on a bus when she met Dan Willoughby.

I start unwrapping the Reeses peanut butter cup and walking the street, she said. All of a sudden I saw this car driving by, a Jaguar.

Driving the Jaguars was Dan, a successful 50-year-old businessman. Dan worked as a sales manager for a international air freight company. Trish Willoughby, Dans wife, was even more successful than he was.

She and her mother ran a lucrative herbal supplement company, with over a million in sales.

Dan saw Yessenia drop the candy wrapper to the ground, so he jokingly reprimanded her for littering. Then, he offered Yesenia and her friend a ride,and drove them to a mall. When he dropped them off, he gave Yesenia his number, and offered to buy her a drink sometime. When he met Yesenia for drinks a few days later, they discussed some business: Dans company had a lot of contacts in Mexico and he was trying to acquire other business contacts south of the border. So, he wanted to learn Spanish.

Just few weeks after they met, Dan invited Yesenia to meet his family.

Dan takes me to his house and introduces me to his kids as his Spanish teacher, said Yesenia.

But she was a lot more than just his teacher. They began seeing each other frequently and Yesenia even accompanied Dan on a few trips to Mexico. Dan was able to give Yesenia a lifestyle that she had never experienced. Soon, she moved to a nicer apartment right down the road from the Willoughbys, and Dans wife foot the bill.

Dan had me living up within a half mile from where they lived, where their actual house was. He would take the kids over there in the afternoons to swim in the pool so the four of them would be out by the pool and Dan would have his Spanish homework papers and he would be basically studying Spanish.

Despite learned Spanish but Dans quest for Mexican business was too little, too late. In July of 1990, his job at the airfreight company came to an end. But, he still paying Yesenias bills and traveling with her. Trish began to resent paying for everything.

She couldnt even find him on the cell phone. She could never find him anywhere and I kept telling her, Trish something is going on theres something wrong here. Why, why cant you get in touch with Dan? said Thera Huish, Trishs mother.

In the fall of 1990, Trish went looking for her husband. The first place she looked was at his Spanish teachers apartment.

She walks in and goes straight in the bedroom tried to turn the light on switch on and saw Dan putting his shirt on. She didnt see me because I got, I got, I hided.

Yesenia said that later in the day, Dan called her and said, Yesenia, my wife is coming to talk to you. If she say something about you and I just deny it. Just tell her that youre my Spanish teacher.

Yesenia said Trish came over the next day and approached her, saying, My understanding Yesenia is that youre going out with my husband.

Yesenia denied it and even volunteered to stop tutoring Dan if it was causing problems in his marriage. But, Yesenia and Dan continued to see each other.

In February of 1991, the Willoughby's went on vacation. They headed to the beachside resort of Las Conchas, Mexico and on the afternoon of February 23, Dan loaded the kids in the car for a trip to a nearby museum. Trish stayed behind for a nap. She was still in bed when Dan and the kids piled out of the car after their trip to the museum. Dan told his children, Go on and tell your mom what, what you saw at the museum.

Instead, the kids found their mom in bed, with a pillow over her head, covered in blood.

The Mexican police took a few Polaroid pictures of the crime scene. They didnt have proper equipment to do forensic evidence and fingerprinting at the time. Items were strewn around the apartment, and it looked like a robbery. But immediately, after the murder, detectives back in Arizona began getting some interesting tips.

Detective Joseph Ruet recalled, We received numerous calls from people telling us, I cant believe he finally killed his wife. And I said, Who? Dan Willoughby, I cant believe Dan Willoughby finally killed his wife.

Several tipsters claimed that the Dan they knew had been cheating on his wife for years. Apparently, when Dan was still employed, he would often use the office restroom and come out smelling like strong cologne. He would say he was going to Digital, one of the companies they did business with. Everyone knew when Dan said he was going to Digital it meant he would be with a woman for the rest of the afternoon. Plenty of callers provided police with the name of Dans current lady friend. Dan was starting to look kinda guilty: It became known that upon Trishs death Dan would stand to inherit Trishs position in her business and gain millions by the death of his wife. A little digging from police revealed that Dan paid the rent for Yesenias apartment, her monthly dues at a local health club and put money in the joint checking account the couple shared. He also went with Yesenia to get engagement pictures shot. He bought a set of his and hers diamond rings, and he and Yesenia were engaged to be married. They had been engaged in the fall of 1990, when both Dan and Yesenia had assured Trish that their relationship was nothing more than student and teacher.

Detectives brought Dan in for questioning and he at behaved like a grieving husband, at first. But when detectives inquired about the money he stood to inherit due to Trishs death, his composure changed. According to detectives, when the issue of finances came up, he was notably perspiring. Dan acknowledged that he would gain several million dollars from Trishs business assets and life insurance. But, he also insisted that he was happily married. He denied that he was having an affair with anyone.

Police also questioned Yesenia. When they asked for her ID, she gave them her social security card. It said Alfredo Patino. The only piece of information police learned was that she had gotten a gender reassignment operation in the 80s.

At a later date, officers took Yesenia to the police station for questioning. During a search of her purse, police found what they believed to be Trishs missing rings. In the interrogation room, Yesenia denied being involved in Trish Willoughbys murder, but she did admit to being in Mexico, partying with friends on the weekend of Trishs death. And, she said she bought that ring from a man that she didnt know on the beach on the day of Trishs murder. Yesenia had a shoplifting warrant from an adjourning jurisdiction, so Mesa police ended up arresting her on that warrant. While incarcerated, the police called Trishs mother in for a positive I.D. on the rings they had found in Yesenias purse. She confirmed they were in fact her daughters jewelry.

On March 4, investigators flew to Mexico to conduct their own investigation of the crime scene and they discovered fingerprints on a Coke bottle in the kitchen.

On March 5, Yesenia was released from jail without restrictions. That same day, the Arizona authorities returned from Mexico and sent the crime scene evidence to the lab. Turns out, the fingerprint was from Yesenia Patino. Police had everything they needed to charge Yesenia with Trishs murder -- except Yesenia. She had run off.

Trishs family blanketed the border with posters offering a reward for information leading to Yesenias capture. They bought advertising space. They put missing posters on the sides of buses and they kept Yesenias picture in the news. And a cross border love triangle with millions at stake was an easy sell for the media.

In December of 1991, the media exposure finally paid off: Crime Stoppers got a phone call from someone who saw Yesenia working in a bar in Mexico.

I was working there and had a good time there but I was afraid, said Yesenia. I was afraid that, that I would, I would get arrested sooner or later.

She was soon arrested in a crowded cantina in Matzatlan.

I said, Yes, Im ready to face the law.

In a detailed confession, Yesenia told police that it all started three months before the Trish was killed, when Trish confronted her about the affair. Yesenia said she gave Dan an ultimatum at that point: her or Trish. Yesenia claimed Dan had agreed divorce his wife. But, he came up with an alternative plan a few days later.

He start telling me on our way to the gym about murdering his wife. I said, No Dan, we cant do that. Divorce her.

Yesenia eventually agreed to the murder plan, once Dan promised he would use the crimes payoff to move to Mexico with Yesenia.

Dan said, according to Yesenia, Yesenia, I cant do it myself. In order for us to be together forever you going to have to help me.

Yesenia claimed her job was to sneak into the vacation house and make Trishs death look like a robbery. She said Dan had murdered Trish earlier by bludgeoning her in her sleep.

Once he hit her, he left with the kids like a go out for a tour or something and I go in and see that shes covered up from head to toes, a lot of blood around the walls.

Yesenia did admit to stabbing Trish in the head. But, according to her, it was an act of mercy. She said she could hear Trish moaning, so she tried to finish her off, by putting a butter knife into her temple.

The day after Yesenias confession, Dan was arrested.

In April of 1992, Dan Willoughbys murder trial began, and by May the jury found Dan Willoughby guilty of murder and he was sentenced to death. Following Dans trial, Yesenia returned to Mexico and pleaded guilty to murder. She expected to be granted leniency because of her plea, but a Mexican judge sentenced her to the maximum - 35 years in prison.

In 1995, three years after the murder case was closed, Yesenia Patino penned a letter to the judge who had sentenced Dan to death. In it, she claimed that she murdered Trish all by herself, and that Dan Willoughby had nothing to do with it. Arizona authorities flew to Mexico to interview Yesenia. According to her new story, she had snuck into the house after Dan had left with the kids, then bludgeoned Trish to death.

I was upset with that because the ring that it was bought for me, Yesenia said of writing the letter. It was never returned to me. They kept it as a state evidence. They also, they, they didnt help me in getting released like they told me that I would be.

In November of 1999, a judge overturned Dans conviction, agreeing that his attorney had done a poor job representing him. Dan faced a new jury and this time, the prosecution didnt seek the death penalty because they said they could no longer rely on Yesenias testimony. Dans new defense team had hopes for an acquittal when his second trial began in 2001.

But rather than recant her previous testimony as everyone expected, Yesenia told the same exact story she told at the first trial.

My sister said to me, Please Yesenia, say the truth, speak on with the truth. Dont make up things, dont lie, dont, uh; let them, uh, for Dan to be release. He doesnt deserve to be out Yesenia.

So, Trish said again that both she and Willoughby participated in the murder of Trish. A forensic scientist testified that blood spatter at the scene was consistent with Yesenias original testimony and not the letter: the forensics indicated that Trishs body had endured two attacks at two separate times.

The jury found Daniel guilty, again. He received two consecutive life sentences consecutive.

Trishs mother wrote Yesenia a letter, telling her she forgave her for what she did.

Because I think she was a victim, just like everybody else.

It is nice to know that she has nothing against me, said Yesenia. She says that Dan is where he belongs to be, and that she feels sorry for what Im going through.

Yesenia Patino is serving her 35-year sentence at the state prison in Hermosillo, Mexico. Dan Willoughby is serving two life sentences and he maintains his innocence. Trishs brother raised the Willoughby children, who are now all adults.

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Anatomy Of A Love Triangle: Husband Kills Wife For Insurance Money And His Transgender Lover - Oxygen (blog)

Grey’s Anatomy – Syracuse New Times

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The New York State Blues Festival will celebrate its 25th anniversary on Friday, July 7, and Saturday, July 8, with two days of free music events at downtowns Clinton Square. The fest, which started in 1992, took pauses in 2010 and 2013, but came back strong and seeks to continue the tradition with this years acts including The Nighthawks, Amy Helm, Chris OLeary Band, Slam Allen and more.

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The festivals closing show provides a strong example of the continuing Southern blues rock tradition with JJ Grey and Mofro. The Jacksonville, Fla., band came up the hard way starting in the mid-1990s, as Mofro, with years of day jobs and touring before finding greater success with the 2007 release of Country Ghetto on Alligator Records. The Sun is Shining Down was featured on the third seasons finale of the Netflixseries House of Cards and the 2008 LP Orange Blossom continued the bands growth. Since then, the band has released The Choice Cuts (2009), Georgia Warhorse (2010), Brighter Days (2011), This River (2013) and Ol Glory (2015).

Grey says the next album is on the horizon. I just got out of the studio yesterday, he said in a phone interview with the Syracuse New Times from his 26-acre Jacksonville farm. Im just getting started.

Grey, now 49, discussed his philosophy on music, his connection to the late Gregg Allman and his temperamental rooster, all with a sense of humor, yet also with a sincerity that comes through vividly in his music.

Where are you right now?

Im on my farm. Its full of pecan trees. It used to have 60,000 chickens in the houses. My grandparents got out of the business, thankfully. Its tough on people their age. I have 15 chickens now, or used to. Bobcats, eagles, hawks, all kinds of stuff are trying to get at them. I love chickens. Here, its one part chicken paradise and one park Jurassic Park.

Any other animals around?

My rooster. Hes a good rooster. He was gonna start with me, but he walked off. If I was here every day, hed settle in with me. But Im in and out. Im not here all the time. Everything is automated for the chicken house. It can run itself for days. Solar doors let him in and out.

What got you started in music?

I never really gave it a whole lot of thought. It just kind of happened. I compare it to a salmon swimming upstream. Whats going on in my life is me swimming: I have to go in that direction. I feel compelled to do it. Its not something Ive ever had a choice in, in a wonderful way.

When did you decide its what you wanted to do for a living?

It happened over a period of time. At first, you just dont want to look like an idiot. You want to look cool when you first do it as a kid. Then, time goes on and you start being you and you stop being who you thought you should be, without effort. Your idea of how good or bad you thought you did that night starts to fall away and you just want to share a moment with the audience and yourself. I really enjoy it.

When did you start touring full time?

I started singing in bars when I was 17 and touring full time around 2001. It was a struggle at first. I worked at the lumberyard, too. I would go on the road and go right back to work. I wouldnt have been able to do it without them allowing me the time off.

When did you quit the lumberyard to pursue music full time?

Probably around 2005, 2006. The first four years of touring I slept four hours a night perpetually. But I never even thought about it like that (relief upon quitting the lumberyard). I still come home and go to work. Theres always something, like whatevers broken on the farm.

My house got flooded in the hurricane in October. They made me lift my house. There were five inches of water in it and its sitting up in the air right now, so Im figuring stuff out. Its no big deal. It is what it is. But theres always something.

You never felt relief upon quitting the day job?

Music is a byproduct of my life, not the center of it. I dont have a process for songwriting as much as the process is just part of life as its coming to me. It finds me more than the other way. I dont take it seriously. I want to honor it and be dignified with it, treat it with dignity, but I dont take it seriously. Same as life.

So what is your goal with your music?

The most I can hope for is it will lead to a place, for me, where I can share an honest moment with an audience. You start to become so in your own skin for a few hours at a show, that it starts to permeate the rest of your life. Youre living these moments, not once in a while or only on stage. You try to live in the zone all the time, where things flow and move a lot easier, to a pace thats enjoyable.

As far as Im concerned, speed and time, theyre abstractions. Theyre things that fluctuate depending on whos experiencing them and the frame of mind youre in. Take that into perspective. Reality isnt as real as were led to believe coming up.

How does that translate into your live show?

I just go where the microphone takes me. We all go together. I tried to be an entertainer years ago. I wasnt any good at it. Honestly, it was boring to me. Some people are really good at it and blow you away. They suspend reality for a while. I was never good at it.

Honesty was always the best policy for me. So I try to be as honest as I can. I reckon Im about half-honest. Its not always easy to let go of the nonsense and let it all be what it is.

Can you tell me about your experiences with Gregg Allman?

Gregg did a lot for me over the years. I played shows with the Allman Brothers and with Gregg himself. Hes a character. Hes awesome.

Now Derek (Trucks, nephew of Butch Trucks, the late Allman Brothers Band drummer who performed at the 2016 Blues Fest) and Susan (Tedeschi) have assumed the mantel of the Southeast music mafia. Theyre at the top of the family now. I wouldnt have been able to do what Ive done without all of them. Its a family, incestuous in a great way, and Im happy to be part of it. Families fight each other and love each other, but theyve all helped me tremendously and Gregg was at the pinnacle of that.

What is most important for people to remember about Gregg?

I dont need to add anything to that. Everybody knows what he was. Dude had soul. His brother (Duane) had soul. Those guys, theres nothing I can add to who they are. Theyre heroes and great people. I was fortunate enough to meet a lot of them. Its been a great thing to meet these people and learn from them. Theyre all down to earth and cool.

One music promoter said that its a crucial time for music to bring people together. How do you feel about that?

I go out there and travel a lot and meet lots of people. Friends and families of mine have different perspectives of the world, and its a great thing.

I truly dont find that we are as ultra-divided as the news media paints. There are always people who are extreme, whatever direction theyre coming from. People build an identity and ideology and they feel threatened because theyre tied to that. But with an identity, you can change your mind about things.

If Im JJ Grey and Im a singer, if I lose my voice, am I still a singer? All those things are just thoughts. And the craziness they show on TV, the handful of people doing and saying crazy things, makes the world appear to be so divided, but its miniscule compared to the 300 million living in the country. You can be politically divided, one red, one blue, but have 99.99999 percent in common.

So things arent as bad as they seem?

People think things arent as good, but they are. Theyre as good as theyll get a chance to be. Dont get me wrong: Someone will get their ass beat tonight, drunk at a bar in Jacksonville, but do we all need to tune into that and develop an opinion on that? Whether someones drunk on booze or drunk on power? Im not much of a political-stand person. Im not much about government, but I am about people. The more attention we give the bad, the worse it is.

What do you want to tell people who are seeing you for the first time?

Be ready to share an honest moment. Let go and let it happen. Dont try to fight it or resist it. Let it go and let it happen. Lets have a party.

What advice do you have for up-and-coming musicians?

Its almost clich, but just do what youre doing. Dont get caught up in the idea of thinking this should be this way or that way. Thats what kills most bands: Young guys or girls going out there thinking theyll be big, partying, people screaming. No, this shits work!

I compare it to Michael Jordan. He doesnt think out every step. He goes in, puts in the work, and then lets go and lets it happen. If youre beating your head against the wall, youre either wasting your time or you shouldnt be doing it.

And never make a decision based in fear. Its the wrong decision no matter what. Let go of the fear and go with your gut.[snt]

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Grey's Anatomy - Syracuse New Times