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The Art of Neuroscience – Scientific American

The winners of an annual contest capture the brain at its most beautiful

Gray, white and wet, an image of the brain by itself can repulse more often than inspire. But when researchers and artists look past its outward appearance, they can reveal thrilling images of the organ that the rest of us would otherwise never see. Though many of these images resulted from lab work and research into how our nervous system functions, they easily stand alone as artclearly a neuroscience degree is not necessary to appreciate the brains intricacies.

For the seventh year in a row, the Art of Neuroscience competition out of the Netherlands Institute for Neuroscience in Amsterdam asked researchers and artists to submit their paintings, renderings, magnifications and videos of animal brains. The committees winning entry and honorable mentions are presented below, along with a selection of Scientific American editors favorites.

Leslie Nemo

Leslie Nemo is Scientific American's editorial intern.

Liz Tormes

Liz Tormes is the assistant photo editor for Scientific American. She lives in Brooklyn with her husband and two dogs. Follow Liz on Instagram.

Neuroscience. Evolution. Health. Chemistry. Physics. Technology.

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The Art of Neuroscience - Scientific American

Physiology-driven genetic changes have positive influence on brain development – News-Medical.net

July 31, 2017

SCIENTISTS in the UK and India have discovered more evidence that positive stimuli in early childhood can benefit the infant brain.

A comparative study of genetic variations between two parts of the brain found evidence for progressive variations in the brain's genome benefiting physiological development.

And they believe such variations may be linked to the level of brain activity determined by so-called 'nurture' factors, which are environmental rather than hereditary.

"The implication is that early life positive experiences can stimulate cognitive activities and will favor such 'beneficial' variations, whereas, negative experiences or lack of cognitive stimulation can reduce the genomic diversity resulting in limiting brain capacity," said Dr Arijit Mukhopadhyay, a researcher in human genetics and genomics at the University of Salford.

It is one of the first studies to show the effect of brain activity on genomic changes, and is published in F1000 Research, Dr. Mukhopadhyay and colleagues from CSIR-Institute of Genomics & Integrative Biology, Delhi.

Dr. Mukhopadhyay explains: "It is generally assumed that as we inherit our genetic blueprint (DNA) from our parents, we also inherit the genetic variations alongside. While this is largely true, this research along with other reports in the recent literature shows that some variations - termed de novo somatic variations - occur as a normal process and are added to diversify our genetic repertoire.

The team collected two different parts of the human brain, frontal cortex and corpus callosum from multiple individuals, postmortem, from the Brain Bank, (the individuals died due to road accidents without any known disease.)

The researchers extracted DNA from the tissue and performed state-of-the-art genomic sequencing to identify genetic variations between the two. The study found a higher number of possibly 'beneficial' variations in the cortex compared to the corpus callosum of the same individuals.

Dr. Mukhopadhyay said: "This finding is an important step in our understanding of early brain development and of how local genetic variations can occur and shape our physiology.

"It is likely that genetic variations beyond those we inherit are important for our ability to adapt and evolve locally for specific organs and tissues.

"We believe our results indicate that such physiology driven genetic changes have a positive influence on the development of the neuronal connectivity early in life."

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Physiology-driven genetic changes have positive influence on brain development - News-Medical.net

Anatomy of an Ad: How Driven helped 100 women ‘Feel Good’ in skinny dipping spot – The Drum

At a time when the soft drinks market is crowded with health-conscious products, Feel Good aims to carve out its brand positioning by extending a message of positivity to women in its latest 'all natural' ad. The Drum went on set (and participated in the ad) to get a first-hand look at the campaign.

With the launch of a new 100% natural range of flavoured water drinks, Driven Agency was tasked with bringing the Vimto-owned Feel Good brand to life with an integrated campaign.

"Obviously the brand is called Feel Good, so the clue is in the name," said Graham Drury, partner at Driven, on the genesis of the idea. We wanted to capture something that actually meant something. Its all about this feeling of liberation and freedom.

"We had to find somewhere private and beautiful so when people arrived they felt comfortable. Finding this place was a a dead important part of the jigsaw."

The idea was to create a documentary-style film where client-side senior brand manager Becky Unwin rallies 100 women to go skinny dipping with her in Spain, tracking the journey from start to finish and how the women feel during the experience.

The shoot took place in rural Andalucia with an all female crew and led by director Nicky Woodhouse from Maker Projects, who incorporated underwater cameras, drones and Go Pros into the production of the film in order to capture every moment.

With an event like this we needed to capture it from all angles. Its not something you can do loads of takes of; its pretty much a one take wonder, said Jennie Ferrar, deputy creative director at Driven.

We knew there was a window where we had the 100 women all together so the best way to capture it was an underwater a camera, Go Pros on peoples heads, a drone in the sky to see the location, and of course our director behind the camera. So it was really throwing everything at that moment this had to be spontaneous, Ferrar added.

To recruit the 100 women, Becky Unwin of Feel Good drinks took to social media, called acquaintances and even approached strangers in the street.

If wed have planned it down to a T it wouldnt have had that seize of the moment quality, though it did come with its downsides, Unwin mused.

We had some challenges, obviously. The week before we were due to shoot we didnt have the full quota. There were people who were maybes, or waiting on flight details. It was very difficult to co-ordinate as people needed to organise shift swaps, child care, so there were a few hairy moments, but we got there in the end."

In addition to the documentary style film, Feel Good is executing an experiential campaign where people can hop into a 'Feel Good taxi', as well as a consumer PR campaign, radio and out of home plans in August. MEC is handling media buying while Social Chain is engaging in an influencer campaign with some of the skinny dipping participants.

"Theres only certain types of clients youd lay this challenge out to. We proposed that we do this for real, live, where theres nowhere to hide," Drury said.

"The client has taken a big leap of faith and we have managed to pull it off, I think. From an agency perspective, I've never seen staff moved to tears of relief during a campaign."

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Anatomy of an Ad: How Driven helped 100 women 'Feel Good' in skinny dipping spot - The Drum

‘Grey’s Anatomy’ Alum Returning For Season 14 – People’s Choice

Johnni Macke 4:08 pm on July 27, 2017

(Photo Courtesy: ABC)

A Greys Anatomy original is heading back to Grey Sloan Memorial Hospital next season, and its great news for longtime fans of the ABC doctor drama.

After serving as the head writer and executive producer for Greys from seasons one through seven, Krista Vernoff is officially back as showrunner, TV Line has confirmed.

With news that Greys most recent showrunner, Stacy McKee, is moving to Shonda Rhimes upcoming firefighter spinoff serieswhen it debuts, fans can rest easy with Vernoff at the helm of the veteran drama. The showrunner will reportedly be working alongside Rhimes and her TV partner Betsy Beers this season, beginning with the premiere.

TV Line reports that in addition to being the showrunner this season, Vernoff wrote the season 14 premiere, Break Down the House, which is already being filmed in Seattle.

In fact, Vernoff has already shared a few pictures from set hinting that episode one is already wrapped and ready to go. Can you believe it?!

Thats a wrap, Seattle! Thank you for the weather and for my sparkle hat! (Its like a sparkle pager, only hattier!) #GreysAnatomy, Vernoff captioned a selfie with Kevin McKidd, who played Dr. Owen Hunt.

We cant wait to see what Vernoff and the rest of the Greys Anatomy team has in store for us come this fall! Until then, we will just have to look at thepictures that the cast including Ellen Pompeo, Jesse Williams, and morehave been sharing from their current adventures in Seattle.

Greys Anatomy returns for season 14 with a two-hour premiere on September 28, 2017 on ABC.For the latest pop culture news and voting, make sure to sign up for the Peoples Choice newsletter!

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'Grey's Anatomy' Alum Returning For Season 14 - People's Choice

‘Grey’s Anatomy’ Season 14 Feels ‘Vintage,’ Teases Star – People’s Choice

Pamela Gocobachi 9:05 am on July 28, 2017

(Photo by ABC/Mitch Haaseth)

Greys Anatomyis about to take it way back! The ABC drama is gearing up for a fourteenth season thats apparently going to make long-time viewers of the series incredibly happy.

According to actor Kevin McKidd, who plays Dr. Owen Hunt, season 14 of the hit medical drama starring Ellen Pompeo will be heavy on the old school Greys Anatomy vibes.

Its fantastic, wrote McKidd via Twitter when one fan asked what we can expect from this years season premiere. Funny and feels like vintage @GreysABC.

Vintage Greys Anatomy? Sign us up, please! Its nice to hear that the show could potentially be going back to its roots in terms of tone especially considering how many of the original actors weve had to bid farewell to over the years.

Though McKidd didnt go into details via Twitter, the reasons Greys Anatomy season 14 in particular might be so reminiscent of earlier seasons of Greys Anatomy could have something to do with the return of executive producer Krista Vernoff.

On Thursday (July 27), we learned via TVLine that Vernoff, who served as the head writer and executive producer for Greys Anatomyfrom season one through seven, is officially heading back to spearhead season 14.

Vernoff will be taking over showrunner duties from Stacy McKee, who has been tasked with helmingShonda Rhimes upcoming firefighter spinoff series. As sad as well be to see McKee go, we cant deny that were excited to have Vernoff back.

We cant wait to see what Vernoff, who is said to be working closely with Rhimes and her TV partner Betsy Beers, has in store for us this year!

(H/T MovieFone)

Greys Anatomy returns to ABC with a two-hour premiere on September 28.For the latest pop culture news and voting, make sure to sign up for the Peoples Choice newsletter!

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'Grey's Anatomy' Season 14 Feels 'Vintage,' Teases Star - People's Choice

Jesse Williams, Justin Chambers, Grey’s Anatomy cast throw first pitch at Mariners game – For The Win

https://usat.ly/2v67hGs

Jesse Williams, Justin Chambers, Greys Anatomy cast throw first pitch at Mariners game

Jackson Avery, Alex Karev, Owen Hunt and Ben Warren at Safeco Field.

I found this on FTW and wanted to share: %link% For more great sports stories ... *visit For The Win: https://www.ftw.usatoday.com *follow @ForTheWin: https://www.twitter.com/forthewin *like FTW on Facebook: https://www.facebook.com/usatodayftw

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Jesse Williams, Justin Chambers, Grey's Anatomy cast throw first pitch at Mariners game - For The Win

Anatomy of a Goal: Ilsinho’s Goalazo – Massive Report

Welcome to the Anatomy of a Goal, where each week we dissect one goal from the previous weeks Columbus Crew SC match.

For match 22 on the 2017 MLS Season, we take a look at Ilsinhos 20th minute goal that put the Philadelphia Union up 1-0 on Crew SC level as part of the 3-0 loss on Wednesday.

Heres a look at the finish from the Philadelphia winger.

The Union approached Wednesdays match with an offensive mindset, totally unlike its defense-first approach on Saturday. Columbus weathered the Philadelphia attacking storm during the first portion of the match, but still faced a significant amount of pressure from the Union attack.

Phillys opener starts with a 50/50 ball won by the Union midfield. Left back Giliano Wijnaldum picked up the won ball as he is closed down by Justin Meram and Hector Jimenez.

Notice Artur, looking downfield. The Black & Gold center-midfielder decides to hold his position and let Meram and Jimenez defend Wijnaldum.

With Meram closing out his angle to Haris Medunjanin, Wijnaldum slots a pass along the sideline to Marcus Epps.

Though he would has room to turn and run, Epps elects to play a one-time pass back to Medunjanin. Throughout this entire sequence, Philadelphia plays very quick passes, slicing through the Crew SC defense.

With the ball at his feet and a soft cushion from Meram, Medunjanin has multiple options. He can either play a quick pass back to Wijnaldum, a pass up the field to CJ Sapong, dribble the ball forward or a field-switching pass to Roland Alberg.

Medunjanin takes quick touch forward and switches the ball to Alberg.

Alberg receives the ball and finds himself with tons of space along the right flank. Running down the flank, right back Raymon Gaddis spreads the field just to the right of Alberg.

Wil Trapp, just to the right of the referee, and Jukka Raitala shift toward Alberg in an attempt to close down the Union attacker.

With Albergs angle on goal closed out by Trapp and Raitala, the Philadelphia No. 10 slides the ball over to Gaddis, who continued his overlapping run with Alberg.

As Gaddis approaches the ball, he hits a one-touch cross into the box. It seems that Gaddis is looking for Sapong, but the striker is marked by both Alex Crognale and Jonathan Mensah. No matter, Gaddis cross wont have enough power to make it to his striker.

As Gaddis weak cross trickles into the box, Crognale has a simple angle to the ball. If the ball doesnt take a difficult bounce then Crognale should be able to clear the ball or at least send it out of bounds... neither of those things happen.

Your browser does not support HTML5 video.

In the above video, you can see Crognale whiff on this clearance. Its not clear if the ball takes a quick bounce before reaching the center back, but Crognale at worst should have side-footed this ball out of bounds.

Here, you can see the ball slicing up and above Crognale, back into the face of the goal.

As the ball reaches its apex, Jonathan marks Sapong while Jimenez puts himself between Epps and the goal.

All 4 players misplay the ball, and Epps gets an awkward touch into the path of Jonathan, who does a good job to shift in front of the open attacker.

Your browser does not support HTML5 video.

I have included the above video to show Jonathans quick attempted clearance of the ball on this play. The defender quickly got in front of Epps and was able to clear the ball up and out of immediate danger without a full swing of his leg.

The beleaguered center back obviously had his issues later in the first half, but here he did nearly everything he could to bail out his teammates.

As Jonathans short clearance drops, Sapong begins to take aim at an overhead kick. There is not much that Jimenez can do aside from putting his face into the path of Sapongs foot in hopes of drawing a free kick.

Now as Sapongs prepares for his, excellent assist, notice how totally wide open Ilsinho is. The winger is in the vicinity of multiple Crew SC players, but is totally alone.

With no defenders near him, Ilsinho lines up his half volley. . .

. . . and smashes it home.

Ive highlighted the four Columbus players who I think should have been responsible for marking Ilsinho in order of responsibility: Trapp, Raitala, Artur, and Lalas Abubakar.

Lets look at this defensive slip up from another angle.

As Gaddis cross heads into the penalty box, you can see that Artur track Ilsinho. Raitala defends Gaddis while Abubakar covers the middle of the box. Trapp is just sort of hanging out in the general vicinity of a Union attacker.

From this angle, I think you can remove Abubakars responsibility for covering Ilsinho. he attempts to deny the ball into the box, cut off Ilsinhos run were it to continue and then is forced to deal with Crognales mishit.

Now, with Ilsinho lining up his volley, you can see Artur, Raitala, and Trapp all around Ilsinho with no other Philadelphia attacking threats present. Raitala had to recover from the cross, but neither Artur nor Trapp have any excuse not to have picked up Ilsinho. The responsibility for covering Ilsinho falls directly on Columbus two center midfielders. Artur tracks Ilsinho into the box and then decides to hang out in the middle of the box rather than cover the open winger. Trapp sees his man drop out of the play and slowly walks into the box; the captain has to do a better job here.

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Anatomy of a Goal: Ilsinho's Goalazo - Massive Report

The Physiology of Breakups – Study Breaks

You dont need a random writer on the internet to tell you that breakups almost always suck. (Maybe not for your friend Sarah, who claims her breakup was totally mutual and is the type of person who can actually pull off a cardigan, but still.) The end of a relationship is rarely easy.

Afterwards, youre often left sad, confused, frustrated and sometimes even depressed. A person can feel like their whole outlook on love has changed. Some people feel the sadness and heartbreak so acutely that it feels like real physical pain, and some want to do nothing but watch all two-hundred-something episodes of The Office and only leave their bed to greet the delivery guy. However, it turns out that there are physiological and scientific reasons for why you feel so poorly after getting dumpedor ending a relationship, if thats what you want to call it.

First, its important to note that emotional trauma like that of a breakup not only affects us mentally and emotionally, but, consequently, also physically. In a 2011 study, researchers asked participants to look at photos of former partners while monitoring their brain activity. They saw that the areas of the brain typically associated with physical pain light up. In fact, people reported that Tylenol was able to reduce this pain. (Win!)

According to a 2008 study, when people engage in long-term relationships, they often start to regulate each others biological rhythms, such as sleep, heart rate, body temperature and appetite. Given this, a breakup could alter your very physiology, maybe even compromising your immune system.

Also on the physiological front are withdrawal effects. While withdrawal is often associated with substances such as drugs or alcohol, the sudden loss of a lover can also trigger similar effects. Love affects the brain in specific ways: When a self-described person in love sees images of their partner, they experience increased activity in the anterior cingulate cortex, medial insula, caudate nucleus and putamen. Interestingly enough, this activity is not seen in lust-based or platonic relationships. We can also see lessened activity in the amygdala, which processes largely anger- and fear-related emotions, in addition to lessened activity in the posterior cingulate gyrus, which deals with the perception of painful emotion.

In terms of chemicals, being in love will raise activity of dopamine, the chemical that signals feedback for predicted rewards, as well as oxytocin, commonly known as the love hormone. Your body begins to expect these chemical signals and adapts to accommodate them. When a breakup occurs, you are suddenly depriving your brain of all the positive sensations it has come to expect, and your brain doesnt cope well with uncertainty; its strained from the sudden loss of these feel-good chemicals, which it then starts craving.

A study looking at the MRIs of cocaine addicts and people in love but recently single showed several neural correlates in common. The findings are consistent with the hypothesis that romantic rejection is a specific form of addiction, says researcher and professor Helen Fisher.

Besides sadness and pain, a common feeling that people cant shake after a breakup is confusion. A group of studies on college students shows that the students who experienced a recent breakup were more prone to use words such as bewilder and confuse in daily diary entries than people who hadnt been broken up with. When youre in a committed relationship, your sense of self can start to overlap with your partner, meaning that a sudden break is extremely jarring in terms of identity. Researcher Gary Lewandowski found that, while new relationships serve to expand ones self concept, the participants reported that a breakup made their self-concept shrink. This confusing feeling means that people feel uncertain about who they are now that the other half they strongly identified with is gone.

Another reason you may be feeling awful after a breakup is because the unexpected ending of a relationship is essentially a form of unanticipated rejection. Humans fear rejection, a fear that likely stems from the historical implications of being rejected from the group during a primordial time period when grouping together was critical for survival. While you no longer have to fear death due to rejection, our bodies retain some of the physiological responses.

When a study looked at the physical effects of rejection, they found that the participants had a sizable parasympathetic nervous system reaction. The parasympathetic nervous system controls most of the bodys functions that dont need our intervention, like the regulation of our internal organs. The study participants experienced a sudden slowing of their heart rate after rejection, especially if it was unanticipated.

The upside of knowing that the awful feelings after a breakup have scientific backing is that there are also some proven ways to help nudge you back on your feet. (I know theres nothing more nauseating than an outsider patting your arm and saying Itll be okay, but stay with me, please.) Obviously, a clear, linear progression from heartbroken to A-okay is pretty much impossible, but researchers and psychologists can offer some suggestions for making it more bearable. Here is some of the best advice for dealing with breakups.

The Placebo Effect

A study of people who had recently experienced a breakup involved giving participants a saline nasal spray. Half were told it was effective in reducing emotional pain and half were told the truth. The people who received the pain reducing spray not only reported less emotional and physical pain, but MRI scans showed that their brain activity decreased in rejection-associated areas and increased in emotion-controlling areas.

The takeaway? Expectations and beliefs matter. If you believe something is going to help heal your broken heart, its possible that it will work.

On Dealing With the Rejection Response

Remember that, while you cant control these feelings, you can control how you respond to them. Remind yourself that part of what you feel happens automatically and make a large effort to behave responsibly, advises relationship and family therapist Roger Gil.

The way we behave can have a huge impact on how we feel. Ever heard that smiling can make you happier? Theres truth in that. Remember, while it may not align with how youre feeling, making mature choices can seriously benefit you in the long run. You dont want to regret calling up your exor worse.

Reflection

While you shouldnt wallow forever post breakup, a study by Grace Larson shows that people who regularly spoke and answered questions about their breakup reported being able to process it better than the people who simply filled out surveys. This study proposes the idea that calm reflection can actually aid the healing process. However, its important to note that dwelling for too long is not helpful.

Talk to your friends or family about how youre feeling and what the experience has been like for you. Writing about the experience as if youre talking to a friend may also be cathartic and healing.

Positivity

It sounds clich, but focusing on the positive aspects of the ended relationship can actually help you move on. Various studies show that people who coped through positive reinterpretation of their breakup experience were more likely to experience a positive outcome.

Here, again, positive writing can create positive emotions in both the short and long term. Maybe its time to start a journal, eh?

Being broken up with will never be a pleasant experience. Understanding the reasons behind why you feel this pain and sadness post-split is useful, but it cant take away the pain when it happens. We have yet to discover an instant antidote for heartbreak, so accept that recovery can take some time. Luckily, recent research suggests that the majority of people overestimate how long it will take them to recover. Furthermore, Monmouth University psychologist Gary Lewandowski found that many people who went through a breakup reported that it helped them to grow and learn from the experience.

Breakups are painful, but I can promise that it wont hurt forever.

If your breakup has worsened existing depression or if you are worried that youre suffering from new symptoms, here are some hotline resources that you can contact:

Substance Abuse and Mental Health Services Administration (SAMHSA): 1-800-662-HELP (4357)

National Hopeline Network: 1-800-SUICIDE (784-2433)

National Youth Crisis Hotline: 1-800-448-4663

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The Physiology of Breakups - Study Breaks

Physiology profs appointed Mathematical Biology fellows – McGill Reporter

Browse > Home / Kudos / Physiology profs appointed Mathematical Biology fellows

Posted on Tuesday, July 25, 2017

By McGill Reporter Staff

At its most recent annual meeting, the Society for Mathematical Biology appointed 18 people to its inaugural Fellows Program. McGill professors Leon Glass and Michael Mackey, both in the Faculty of Medicines Department of Physiology, were among the researchers recognized by the scientific and scholarly community for their distinguished contributions to the interface between the mathematical and life sciences. The Society held its 2017 meeting at the University of Utah from July 17-20.

Prof. Leon Glass

Prof. Glass is widely known for his 1960 discovery of patterns, now known as Glass patterns, that clarified our understanding of how the human brain processes visual stimuli. His research applies nonlinear dynamics to the understanding of vision, dynamics in genetic networks, cardiac arrhythmias, and dynamical disease. In particular he has worked on problems associated with respiratory rhythmogenesis and the effects of periodic forcing on respiration, dynamics of tremor and motor control, dynamics of cardiac arrhythmia, visual perception, and dynamics in gene networks. Prof. Glass is the Isadore Rosenfeld Chair in Cardiology. His work has earned him accolades that include a Guggenheim Fellowship, the Jacques-Rousseau Prize for Disciplinary Research from the Association Francophone pour le Savoir (ACFAS),and the Society for Mathematical Biologys Arthur T. Winfree Prize.

Prof. Michael Mackey

Prof. Mackey is the Joseph Morley Drake Professor Emeritus in Physiology. His research works to achieve reasonable concordance between biologically realistic mathematical models (of physiological processes at the cellular and molecular level) and laboratory/clinical data. His recent work focuses on the periodic hematological diseases (such as cyclical neutropenia, cyclical thrombocytopenia, and periodic leukemia) and control of the tryptophan and lactose operons. In 2013, an international conference honoring Prof. Mackeys work was held in Lyon, France, to mark the occasion of his 70th birthday.

The Mackey-Glass equation

Glass and Mackey have also collaborated on research. In a 1977 article in the journal Science, they introduced an equation, now called the Mackey-Glass equation, that illuminates how simple control mechanisms can lead to complex bodily rhythms such as the fluctuations in the number of circulating blood cells.

The Society for Mathematical Biology was founded in 1973 to promote the development and international dissemination of research and education at the interface between the mathematical and life sciences. Professors Glass and Mackey are both former presidents of the SMB, having served from 1997-1999 and 2009-2011, respectively.

The full list of 2017 SMB Fellows is online.

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Physiology profs appointed Mathematical Biology fellows - McGill Reporter

Molecules That Could Form ‘Cell-Like’ Membranes Spotted on Saturn’s Largest Moon – Gizmodo

Titan, partially obscured by Saturns rings. Image: NASA/JPL-Caltech/Space Science Institute

Saturns moon Titan is a world of contrast; both eerily familiar and strikingly alien. Its calm seas and enormous sand dunes might remind you of Earth, until you learn that whats flowing across Titans surface is not water, but liquid hydrocarbons. Titans nitrogen-rich atmosphere seems to have some of the ingredients for biology, but any life forms evolved to thrive at temperatures of -290 degrees Fahrenheit would be practically unrecognizable.

A new scientific paper supports the idea that life might exist on Titan, but that it would be nothing like life as we know it. After studying spectroscopic data collected by the Atacama Large Millimeter/sub millimeter Array (ALMA) in northern Chile, researchers are now reporting that Titans atmosphere is rife with vinyl cyanide, a molecule that could, in theory, form cell-like membranes under the moons unique environmental conditions.

In fact, based on the levels of vinyl cyanide present in Titans atmosphere, its seas couldin theory, were not saying there are aliensbe bubbling with tiny cell membranes, with concentrations similar to those of bacteria in Earths oceans.

The membranes that enclose the cells of all living things here on Earth are made of phospholipids, molecules with long, non-polar (water-repelling) tails and polar (water-loving) heads. If you remember high school biology, youll know that phospholipids form a bi-layer, with the water-loving parts on the outside, and the water-repelling bits on the inside. This structure allows membranes to bubble off tiny pockets of water from their surroundings, creating cells that house genetic material and support biochemical reactions.

Thats all well and good for organisms evolved to thrive in the temperate, liquid water seas here on Earth, but the membranes our biology uses simply wouldnt work in the cryogenic methane seas of Titan. (Theyd be far too rigid, and water-loving/water-repelling bits would have to be reversed.) So, what could cells on Titan look like? Two years back, researchers at Cornell University used chemical models to attempt to answer that very question. Through those models, they produced a functional cell membrane that remained stable and flexible at incredibly low temperatures, using none other than C2H3CN, or vinyl cyanide.

They called their hypothetical alien cell an azotosome.

What makes vinyl cyanide potentially useful molecule for this is that its amphiphilicit has a polar and a non polar end, just like our membranes phospholipids, Maureen Palmer, a recent graduate of St. Olaf College and lead author on the new study,explained. It would be sort of the same but sort of the opposite of how cell membrane lipids work on Earth, with the polar bits on the inside, and the non-polar bits on the outside.

It was a fascinating hypothesis, but there was one problemnobody had ever confirmed that vinyl cyanide is actually present on Titan. (NASAs Cassini spacecraft found tentative evidence for the molecule several years back.) Palmerand her colleagues decided to fill in this gap, by examining calibration data ALMA collects at Titan before turning its telescopes to stare at other targets. Sure enough, they found compelling evidence that large amounts of vinyl cyanide are present in Titans atmospheremainly, at altitudes greater than 200 kilometers. The research was published today in Scientific Reports.

When I sent the paper to Jonathan Lunine, Cornell astronomer and co-author on the 2015 study positing the existence of azotosomes, he said it was quite gratifying to see that acrylonitrile, or vinyl cyanide, does indeed seem to be present in Titans atmosphere.

Of course, life as we know it would be more likely to emerge in the vast seas on Titans surface than high up in the sky. But as Palmer and her colleagues point out, rainfall is constantly transporting organic compounds to Titans surfaceand those could include vinyl cyanide. It should be reaching the surface, she said. Titan has lots of rain.

In fact, in Ligeia Mare, a methane sea larger than Michigans Lake Superior located near Titans north pole, Palmer and her colleagues estimate there could be as many as 30 million azotosomes per cubic centimeter of sea water. For comparison, costal ocean waters on Earth have about a million bacteria per cubic centimeter, according to one papers estimate.

This is a crucial point and lab experiments ought to be done, Lunine added. Palmer agreed.

Im hoping someone will do a study of trying to form the membranes in the lab, seeing if theyre actually able to form, she said. Her co-authors are currently trying to better constrain the abundance and distribution of vinyl cyanide in Titans atmospherethis first paper was just a rough look. Theyre also searching for evidence of other biologically-relevant molecules on Titan. Also this week, another team of scientists reported the detection of carbon chain anionspotential building blocks of complex biomoleculesin Titans upper atmosphere, using data from Cassini.

Ultimately, resolving the question of whether or not Titan is home to some seriously weird life forms will require a future mission that can land on its surfacemaybe a cryogenic methane-proof submarine. Palmer is definitely rooting for a lander.

I love Titan, Palmer said. Its super interesting as an astrobiology target, because all forms of life we know of on Earth have water as the solvent, but it has liquid methane. It would be a totally different form of biochemistry, if there was life on Titan. I find that possibility fascinating.

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Molecules That Could Form 'Cell-Like' Membranes Spotted on Saturn's Largest Moon - Gizmodo