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Myriad Genetics (MYGN) Grows on Higher Cancer Test Volumes – Nasdaq

On Aug 11, we issued an updated research report on Salt Lake City, UT-based molecular diagnostics provider, Myriad Genetics, Inc. MYGN . The company currently carries a Zacks Rank #3 (Hold).

For the past three months, Myriad has been trading above the broader industry . The company has rallied 24.7%, compared with the industry's 3.7% gain.

Myriad ended fiscal 2017 on a solid note, with its fourth-quarter numbers exceeding the Zacks Consensus Estimate. The company particularly observed strong growth in EndoPredict and GeneSight testing revenues. Also, Myriad witnessed a third consecutive quarter of rise in hereditary cancer volumes. Also, it received provincial reimbursement in Quebec for EndoPredict.

Notably, at the European League Against Rheumatism (EULAR) meeting held in June in Spain, Crescendo Bioscience, a wholly-owned subsidiary of Myriad, released new data from a meta-analysis of clinical studies. The data has demonstrated the Vectra DA test's ability to predict a joint damage.

The same month, the company announced that its BRACAnalysis CDxcompanion diagnostic test has successfully identified BRCA -mutated patients with HER2- metastatic breast cancer in the OlympiAD trial, who have responded to treatment with olaparib better than standard chemotherapy.

Myriad's collaborations with AstraZeneca and BeiGene for development of companion diagnostics also raise optimism. Moreover, Myriad continues to make progress with its kit-based versions of Prolaris and myPath Melanoma in the international market and expects to file for CE Mark for Prolaris by 2018.

Moreover, the company has introduced its 'Elevate 2020' program that targets to achieve $50 million of incremental operating income by fiscal 2020. Per management, the company has selected the projects that are anticipated to deliver $17 million of operating income in fiscal 2018 and another $24 million in fiscal 2019.

On the flip side, unfavorable currency translation continues to be a major dampener for the stock. Management fears that further strengthening of the dollar against foreign currencies will lead to deteriorating operating results.

Intensifying competition as well as the possibility that Myriad's new test might not generate meaningful profits to outweigh the costs associated with its development continues to raise concern.

Zacks Rank and Key Picks

Some better-ranked medical stocks are Edwards Lifesciences Corp. EW , Steris Plc STE and Align Technology, Inc. ALGN . Edwards Lifesciences and Align Technology sport a Zacks Rank #1 (Strong Buy), while Steris carries a Zacks Rank #2 (Buy). You can see the complete list of today's Zacks #1 Rank stocks here.

Edwards Lifesciences has a positive earnings surprise of 10.75% over the trailing four quarters. The stock has gained around 0.9% over the last three months.

Align Technology has a long-term expected earnings growth rate of 26.6%. The stock has rallied roughly 25.4% over the last three months.

Steris has a positive earnings surprise of 0.78% over two of the trailing four quarters. The stock has gained 13.1% over the last three months.

5 Trades Could Profit "Big-League" from Trump Policies

If the stocks above spark your interest, wait until you look into companies primed to make substantial gains from Washington's changing course.

Today Zacks reveals 5 tickers that could benefit from new trends like streamlined drug approvals, tariffs, lower taxes, higher interest rates, and spending surges in defense and infrastructure. See these buy recommendations now >>

Myriad Genetics, Inc. (MYGN): Free Stock Analysis Report

Align Technology, Inc. (ALGN): Free Stock Analysis Report

STERIS PLC (STE): Free Stock Analysis Report

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The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

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Myriad Genetics (MYGN) Grows on Higher Cancer Test Volumes - Nasdaq

Style Anatomy: Urooba Khuro – The Express Tribune

The owner of Pakistans first luxe sleepwear, SlumberGram, speaks to us about what fashion is to her

The owner of Pakistans first luxe sleepwear, SlumberGram, speaks to us about what fashion is to her

Understanding your body is the key to looking good and a trait found amongst all impeccably dressed fashionistas. While people shy away from talking about their bodies, these brave souls explain how they work their anatomies to their advantage

How would you describe your body type?

I would describe it as curvy and petite. I have defined collarbones and shoulders, but at the same time 39 of curves!

Has your body changed over the last five years?

Not drastically, but yes a few pounds here and there.

How has your style changed over the years?

Style is something that is personal and defines your individuality. I feel that mine hasnt changed, but actually just improved.

In your opinion what is the most troublesome area?

I wouldnt call any part of my body a troublesome area as such, but yes sometimes my thighs can be troublesome. Especially when Im buying a new pair of jeans or pants.

How do you dress your body according to your body type?

My all-time favourite look is slim-fit jeans with a slightly loose top. I try my best to wear clothes that dont make me look too short.

In your opinion what is the biggest mistake a person can make while dressing here?

The biggest mistake would be to blatantly imitate the style of other people without considering your own body type and personality.

Which silhouettes suit your body the most?

Anything well tailored suits my body. I dont restrict myself from wearing anything in particular, if it fits well and looks nice, thats good enough for me.

What do you shy away from wearing and why?

Im very experimental when it comes to my clothes, but Im definitely not a fan of revealing my legs and knees.

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Style Anatomy: Urooba Khuro - The Express Tribune

Anatomy of a brutal killing… the brick, the baseball bat and the blood – Independent.ie

He arrived for an unplanned Saturday night visit, after a flurry of phone calls between Martens Corbett and her parents, despite being expected at work on the Monday morning. What was discussed on the phone remains unclear.

2. Molly's screams/no injuries

Martens claims he woke in the middle of the night to find Mr Corbett strangling his daughter. However, she refused a medical assessment at a nearby hospital after police arrived. A witness told the court that Martens Corbett was "rubbing her neck in a scrubbing motion". A paramedic attending the scene said they saw light redness on her neck but no abnormalities.

3. Trazodone sedative

The district attorney's office revealed that traces of a powerful sleep medication, trazodone, were found in Mr Corbett's blood stream. A nurse, Katie Wingate-Scott of the KPC health centre, confirmed to the trial that Martens Corbett was prescribed Trazodone in 50mg doses on July 30 - three days before her husband's death.

4. The brick

A brick Martens Corbett used to hit her husband was shown to jurors. It was covered with blood on both sides. A forensic expert told the court it was used to strike Mr Corbett more than once with excessive force. Martens Corbett said she had kept the brick on her night stand before the attack but did not say why it was in the bedroom.

5. The baseball bat

Martens said he struck Mr Corbett with a baseball bat he brought to the house that evening: "I hit him until he couldn't kill me." It was in the guest room where he was sleeping before he brought it upstairs after hearing a loud noise. The black 'Louisville Slugger' bat was 28 inches long and made of aluminium. Martens brought it to the house as a gift for Mr Corbett's son but it was not given to him. It had previously belonged to his own son, Stewart.

6. Bloodstains on Jason's bed

Forensic expert Stuart James told the court that bloodstains on the bed sheets showed Mr Corbett was struck there. He found blood spatters on the inside of the quilt on the bed, in addition to blood saturation marks inside the mattress. "It may well be where the bloodshed first occurred," he said.

7. Blood spatter

An analysis of the blood spatter patterns around the bedroom showed Mr Corbett was struck on the head while falling and while he was on, or close to, the ground. Stains found on the inside hem of Martens's boxer shorts were said to have travelled upwards and indicated that Mr Corbett was below them when he was struck on the head. Similar patterns were discovered on Martens Corbett's pyjamas.

8. The 911 call

Prosecutors claimed a 911 call after the killing was delayed and said Martens Corbett and her father engaged in fake CPR efforts. The dispatcher who took the call said she was surprised at how calm Martens was as she talked him through performing CPR and chest pumps. "There was no panting, no gasping. He wasn't out of breath," she added.

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Anatomy of a brutal killing... the brick, the baseball bat and the blood - Independent.ie

European Academy of Allergy and Clinical Immunology …

EAACI StatementThe EAACI community is deeply affected by the recent media reports of the death of a young child undergoing an oral food challenge (OFC) in the United States. Firstly, we wish to express our sincere condolences to Alastair Watson's family.

This is the first fatality reported in relation to OFC's and we await the full facts surrounding Alastair's death. While we wait for further details, this statement hopes to reassure the wider allergy community and to highlight procedures that should be followed by those performing OFC's; the gold standard test for food allergy diagnosis.In this regard EAACI has delivered the Guidelines for Food Allergy Diagnosis and Management in 2014 that should serve as best practice of care.

Food challenges are essential for the effective diagnosis and progress management of food allergies and currently cannot be replaced by skin prick or blood IgE, component or basophil activation testing or allergy testing alone. Patients and families should be informed about the potential risks and appropriate consent should be obtained. The OFC has been used safely for decades Life-threatening and fatal anaphylaxis at OFC's are exceptional if proper process and equipment are put in place by the health care professionals involved in oral food challenges. Reviewing internal procedures, setting, staffing and supervision should be performed on regular basis and on individual basis when needed. Ensuring patients safety is paramount. Protocols should be in place following some international guidance such as PRACTALL summarized in the EAACI Guidelines for Clinical practice on Food Allergy and Anaphylaxis, available for download here.

EAACI Pediatric Section

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European Academy of Allergy and Clinical Immunology ...

ALLERGY AND IMMUNOLOGY SPECIALIST – Bangor Daily News

Select a major from the list

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ALLERGY AND IMMUNOLOGY SPECIALIST - Bangor Daily News

Google Combines Neuroscience Into DeepMind AI Platform – Android Headlines

Google has added a new capability to DeepMind that enables its artificial intelligence (AI) platform to take a nap at a given point of time. DeepMind explained in a blog post that the new development in its AI effort incorporates ideas from neuroscience research, a move that significantly complements the typical logic-based and theoretical mathematical approaches to AI. Neuroscience does this through the identification of biological computation that DeepMind believes could have a substantial contribution to helping the platform learn from its environment in a more human-like fashion. DeepMind, therefore, intends for the addition of neuroscience into its AI work to check whether existing AI techniques are functioning as they should and to produce new kinds of algorithms that can be used to create AI-based systems.

DeepMind mentioned a new finding in neuroscience research stating that the human brain is capable of revisiting its earlier neuronal activities during sleep. That means the biological brain can still store and process data from an earlier experience, failed or successful, even if it is resting and consequently make successes in the future. That inspired DeepMind to make its AI platform learn how to sleep. The company argued that while it might appear as though the concept of sleep is illogical in the context of AI as a tool to solve computational problems, the idea is to develop an algorithm that can store a host of experimental data and review those pieces of information while at rest in order to study where it flopped and succeeded in the past. In other words, even if an AI-based computer previously failed to solve a computational challenge, it can still handle training data while in offline mode and use that same information to accomplish the task in the future. The concept forms part of DeepMinds deep-Q network algorithm that uses raw pixels and score data to learn a wide variety of Atari 2600 games.

DeepMind said that some of the challenges that AI can solve in the future with the help of neuroscience include imagination, a concept that the company introduced into two kinds of AI that it developed recently with the goal of helping to plan for the future by learning to separate useful data from irrelevant information. An update on DeepMinds growing AI efforts will likely follow in the coming months.

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Google Combines Neuroscience Into DeepMind AI Platform - Android Headlines

Review: Anatomy of Ferguson, From a Shooting to Activism – New York Times

Photo Brittany Ferrells activism in Ferguson, Mo., is a focal point of the documentary Whose Streets? Credit Autumn Lin/Magnolia Pictures

Whose Streets?, a documentary about the unrest and activism in Ferguson, Mo., in the wake of the 2014 police shooting of Michael Brown, an unarmed black teenager, is choppy, sometimes unfocused, and in every respect the opposite of slick. Its directors, Sabaah Folayan and Damon Davis, are novice filmmakers, true; but I also suspect this movies form is deliberate, part of its message. This is direct and frequently powerful filmmaking that doesnt much care about meeting my aesthetic standards.

A preview of the film.

Whose Streets? takes off from the night Mr. Brown was shot. One of the movies subjects is David Whitt, a resident of the apartment complex on the street where the shooting took place, who is moved to take his video camera onto the streets to record police action as rioting started. Another thread follows Brittany Ferrell and Alexis Templeton, a couple navigating parenthood and school, and putting themselves at considerable risk as they lead and participate in demonstrations like one in which they formed a human chain to block traffic on a highway.

The movie is punctuated with quotes by black historical figures Martin Luther King Jr.s observation that a riot is the language of the unheard is particularly resonant. Much of the footage is from low-resolution video cameras and cellphones; the most professional-looking material here is from a television interview with Officer Darren Wilson, who shot Mr. Brown, in which he says, You cant perform the duties of a police officer and have racism in you. This is shown in the same section that features on-the-fly shots of off-duty St. Louis police officers puffing their chests at activists at a town hall meeting. Another wrenching scene shows a protester trying to address a black female officer, the only person of color in a defensive line of cops; she holds her position even as tears fill her eyes.

Whose Streets?

Directors Sabaah Folayan, Damon Davis

Stars Brittany Ferrell, Tef Poe, Kayla Reed, Tory Russell, Alexis Templeton

Rating R

Running Time 1h 30m

Genre Documentary

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Review: Anatomy of Ferguson, From a Shooting to Activism - New York Times

Anatomy of a world championship: How ‘tiny’ Tom Walsh shot down the giants – Stuff.co.nz

MARC HINTON

Last updated05:00, August 13 2017

REUTERS

Tom Walsh wasn't the strongest in the world champs shot put field, but he did throw the furthest legally.

It was Jake the Muss in the iconic Kiwi movie Once Were Warriors who brutally encapsulated the delicate balance between "too much weights and not enough speed work". Tom Walsh may just have taken that theory to another level with his world championships shot put triumph in London.

Walsh tipped the shot put form book on its head when he knocked over the heavily favoured American duo of Ryan Crouser and Joe Kovacs to claim his first IAAF World Championships title, and continue his groundbreaking ways.

These are good times to be Tom Walsh, a part-time builder from Christchurch (by way of Timaru) who is laying some impressive foundations as an athlete. Last year he became the first Kiwi male to win a world indoors title; then followed that up by claiming New Zealand's first men's field event Olympic medal (a bronze) in Rio; and also becoming the first bloke from these parts to claim an overall Diamond league crown.

KAI PFAFFENBACH/REUTERS

Tom Walsh throws in the men's shot put final in London.

Now with his world championship triumph early Monday (NZT) at London's Olympic stadium, Walsh has struck a further blow for blokedom, becoming the first Kiwi male to make the podium at the global event. The US$60,000 (NZ$82,000) bonus he achieved for doing so was just a delicious icing on the cake.

READ MORE*Walsh fires up over protests*Groin tear won't hold Walsh back*Walsh banks $82,000bonus

It wasn't easy for Walsh in London as he had to suck up an agonising groin tear on the eve of the event and compete through gritted teeth, and then survive multiple protests from both Crouser and Kovacs in the aftermath that left the final outcome in doubt right up until just minutes before the medal ceremony the next evening.

But the protests were all eventually thrown out and Walsh was able to limp on to the podium to receive a richly deserved gold medal that was a blow not just for the underdog, with Crouser and Kovacs owning the year's 10 biggest throws between them, but also for the comparative "little guy".

Yes, Walsh, at 1.85 metres and around 124kg is pretty damn big to be anyone's idea of small. But these things are comparative.

Crouser, a giant of a man, stands 2.03m and tips the scales around 141kg. The more compact Kovacs is still a full 10kg heavier than Walsh. They are both power men. They muscle the shot put, rather than finesse it.

Brazilian monster Darlan Romani, who was fifth in Rio last year but failed to make the final in London, nudges the scales at 140kg and is reputed to be bench-pressing 300kg in his workouts.

"There are two major ways to throw," says Walsh. "You can be strong or you can be fast. I'm not overly strong and I'm not overly big either. I'm definitely the speed and rhythm kind of guy. Most of the guys are strength kind of guys get very strong in the gym and you'll throw far.

"Yes, I am stronger than probably 99 percent of Kiwis. But in terms of world shot put I'm not overly strong.

"Put it this way, if it was a strongman contest, I'd be way out the arse-end."

But it's not. The pre-throw whirly-gig routine in the circle is as important as the actual release of the 7.2kg silver sphere. And the 25-year-old Walsh is so very good at generating the low-to-the-ground speed that then transfers into power on the throw.

For a big man, he is remarkably light on his feet, and it's an attribute he has honed into a game-changing point of difference.

Not that Crouser, whose only quality throw in London was red-flagged (thus his protest, and then re-protest), can be surprised by what played out. Back in February, when he beat Walsh twice in meets in Christchurch and Auckland by throwing over 22 metres in both, he remarked about the difference in style.

"I'm bigger and stronger than I was last year, so I'm kind of muscling it out there," he said after throwing 22.15m to win the Auckland Track Challenge. "You see Tom is lot quicker and has a lot more finesse than I do, and he's definitely in cleaner form.

"He's an unbelievable competitor, and he's one of those guys you can have a big lead on and he can throw a monster when the pressure is on. You never really beat Tom till that last throw is done."

What Walsh has also become is the most consistent performer on the shot put scene. He had five of the top six throws in London with a series of remarkable quality: 21.38m, 21.64m, 21.75m, 21.70, 21.63m and, then, saving his best for last, 22.03m.

On a day when his rivals struggled to find their best stuff at least legally the smiling Kiwi was quite simply a man apart.

Walsh puts that down to his accent on technique, timing and speed, and a strong mindset that has been a big part of the work undertaken with coach Dale Stevenson and sports psychologist John Quinn.

"Mentally I was in a really good place. I knew exactly what I needed to do and I stuck with that. Dale and John and I always talk about sticking to what's been working in training, and what has been working in training is getting out and around at the back of the circle.

"That means flowing through the back of the circle in terms of acceleration, and then a strong left side. If I've got a strong left side, all my power goes into my left side and it pops up, and that keeps me in the circle."

Remember, the best throws of both Crouser and Kovacs in London (both would have won the gold medal if legal) were red-flagged. The sport is not just about chucking tin a long way. But doing it within the rules of the game.

Walsh does a lot of mental work now. It's something he's, well, got his head around.

"When you're young, you don't think it's important. You think physical attributes are important. I bombed out at the world juniors the year Jacko (Kiwi rival Jacko Gill) won. I went from throwing 20 metres in the warmup area to throwing 18 metres in the competition arena.

"I thought, 'well, what's the reason?'. From there, it's been a long and gradual process over the last seven years to get to where I am now. My routines are very structured and I know exactly what works for me."

The burly Kiwi is also a competitor. "It was great to come in when everyone was talking about those two (Crouser and Kovacs) and do the deed. No one was talking about me, and that was good. Kiwis compete well with a chip on their shoulder.

"It's a great feeling to know we've achieved what we set out to after Rio. We said we'll probably need to throw mid-22s to win in London. I got myself into that shape, but on the day no one managed to throw that far, and I took the cake."

Yes, the sweet taste of success went to not the biggest, meanest or strongest. But the man who figured out that if you don't get the balance between speed-work and weights, there is most definitely a price to pay.

-Sunday Star Times

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Anatomy of a world championship: How 'tiny' Tom Walsh shot down the giants - Stuff.co.nz

Cellular ‘garbage disposal’ units fingered in Alzheimer’s development – FierceBiotech

Lysosomes play an important role in cells: They break down old material so the body can dispose of it. Now, scientists at Yale University are zeroing in on lysosomes in the brain, and they believe theyve discovered how these garbage disposal units may contribute to the buildup of the amyloid plaques characteristic of Alzheimers disease.

The Yale researchers discovered defects in the process by which lysosomes travel within neurons. And when this transport goes wrong, lysosomes build up in swollen axons that surround amyloid-beta, the protein thats associated with brain plaques. The team published thefindings in The Journal of Cell Biology.

RELATED: Alzheimer's hopes dashed as Lilly gives up on amyloid drug solanezumab

When lysosomes travel from the ends of axons into the center of neuronal cells, they mature and develop the ability to degrade old cell components. But sometimes they get stuck in swollen axons and fail to mature. The Yale scientists werent sure how this defect contributed to the buildup of amyloid plaque, so they designed an experiment in which they interfered with the transport of lysosomes in mouse neurons.

They discovered that when neurons are deprived of a protein called JIP3, they fail to properly transport lysosomes from the axons, according to a statement. Swollen axons also accumulate amyloid precursor protein (APP) and two enzymes that cause APP to generate amyloid-beta: BACE1 and presenilin 2.

When the team removed a copy of the gene that makes JIP3 from mouse models of Alzheimers, the animals produced more amyloid-beta, and they formed larger plaques surrounded by an increased number of swollen axons.

"Collectively, our results indicate that the axonal accumulations of lysosomes at amyloid plaques are not innocent bystanders but rather are important contributors to APP processing and amyloid plaque growth," said co-author Shawn Ferguson of the Yale School of Medicine in the statement.

The so-called amyloid hypothesis in Alzheimers remains controversial. Many neurological researchers believe amyloid plaques are central players in the disease. But efforts to target those plaques with drugs have been disappointing so far. One of the most high-profile anti-amyloid drugs was solanezumab, Eli Lillys experimental Alzheimers drug, whichthe company abandoned in 2016 after years of failed trials.

But researchers are still investigating new ways of preventing amyloid from building up in the brain. In June, for example, a University of Cambridge team described computer-generated antibodies they developed that prevent amyloid-beta from clumping together and forming plaques.

RELATED: Designer antibodies block Alzheimers plaque from forming

The Yale scientists believe that as they learn more about how deficiencies in lysosome transport contribute to amyloid plaques, they may be able to identify strategies for modulating proteins in the brain to repair the process. Their research might also aid efforts underway to examine how genetics and other risk factorsincluding traumatic brain injuriescontribute to Alzheimers.

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Cellular 'garbage disposal' units fingered in Alzheimer's development - FierceBiotech

The stupidest thing you can do with money – The Durango Herald

You may have guessed that Im a bit of a freak when it comes to personal finance. Only a freak would get up at 5:30 a.m. on a Saturday to write about money. Right?

Given that, it shouldnt surprise you that Freakonomics (www.freakonomics.com) is one of my favorite podcasts. Freakonomics explores the hidden side of human behavior and how we make decisions behavioral economics through stories and interviews.

A recent episode, called The Stupidest Thing You Can Do With Money, grabbed my attention.

The show addresses two options for investing:

1. Hire an investment adviser, who studies the financial markets using sophisticated tools and actively manages your money to get you the best return.

2. Do-it-yourself investing passively invest with a set-it-and-forget-it attitude.

Investment advisers give their clients advice about where and how to invest, charging fees either as a percentage of assets under management, typically 1 to 2 percent, or a flat amount. There are about 300,000 investment advisers in the United States. Most of them must beat the market, right? Why else would we keep paying them?

The truth is most people are paying fees to their investment advisers for sub-par returns on their investments. Ninety-five percent of actively managed portfolios cant consistently beat the S&P 500 index after subtracting fees.

An S&P 500 index fund is a low-cost way to own a diversified portfolio. The fund owns stocks in 500 of the largest U.S. companies the S&P 500, which spans many different industries and accounts for about three-fourths of the U.S. stock markets value.

And its not just your investment adviser who cant beat the market. Harvard University has an endowment of $38 billion and access to some of the best and brightest minds and top computer-modeling tools. Yet, the universitys annualized net return on investment for the past 10 years was less than 6 percent. The S&P 500 earned 7.72 percent over the same period.

Welcome to the low-cost, index fund investing DIY revolution. Not only are low-cost mutual funds, such as S&P 500 index funds and total stock market index funds, beating actively managed portfolios, they are doing it at a lower cost.

Jack Bogle, founder of Vanguard and the worlds first index fund, says this about fees: If the market return is 7 percent and the active manager gives you 5 after that 2 percent cost, and the index fund gives you 6.96 after that four basis point cost you dont appreciate it much in a year but over 50 years, believe it or not, a dollar invested at 7 percent grows to around $32 and a dollar invested at 5 percent grows to about $10.

Its time to join the revolution.

Durango resident and personal finance coach Matt Kelly owns Momentum: Personal Finance. http://www.personalfinancecoaching.com.

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The stupidest thing you can do with money - The Durango Herald