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Department of Cell Biology | NYU Langone Health

The Department of Cell Biology at NYU Langone Health brings together scientists who study the mechanisms that control essential aspects of cell behavior.

Our faculty investigate the basic principles of gene function and aim to elucidate cellular changes associated with health and disease. Using modern imaging tools and quantitative techniques, we lead innovative research projects that take a cellular approach to research areassuch as cancer biology, developmental biology, stem cell biology, structural biology, immunology, and neurobiology.

Our research is intertwined with our teaching mission. Through intensive, interdisciplinary training programs, our faculty mentor a new generation of cellular biologists, helping them build the skills they need to lead labs of their own.

Our laboratories and offices are located in multiple NYU Langone research facilities. We have research space in the Skirball Institute of Biomolecular Medicine and in the Medical Science Building, both located at 540 First Avenue in Manhattan. We also have space on the sixth floor of the West Tower of the Alexandria Center for Life Sciences at 430 East 29th Street.

For general inquiries, email Kalyani Narasimhan, PhD, executive director, at kalyani.narasimhan@nyulangone.org.

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Department of Cell Biology | NYU Langone Health

Grey’s Anatomy Renewed for Season 16 and 17 at ABC

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The doctors of Grey Sloan are checking in for at least two more seasons. ABC announced Friday that Shondaland's groundbreaking medical drama Grey's Anatomy has been renewed for Seasons 16 and 17. The news isn't surprising given the show's consistently strong ratings, which top Thursday nights with an average of more than 6 million viewers per week, but it's still an impressive feat nonetheless.

The network also revealed that Station 19 has secured a third season and that How to Get Away with Murder will return for Season 6, ensuring that this current TGIT lineup will remain intact next year.

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Grey's, which is currently airing its 15th season, reached a major milestone in February when it surpassed ER to become the longest-running medical drama in TV history. The monumental season also saw Meredith (Ellen Pompeo) finally open her heart to love again with DeLuca (Giacomo Gianniotti), and welcomed the hunky ortho god Link (Chris Carmack) into an already stacked roster of unbelievably good-looking surgeons. Plus, Season 15 featured the return of Owen's sister Megan (Abigail Spencer), who roasted her big bro over his disastrous handling of Teddy's (Kim Raver) pregnancy, as well as the on-screen debut of the late Derek Shepherd's (Patrick Dempsey) elusive fourth sister Kathleen (Amy Acker).

Grey's Anatomy wraps Season 15 on Thursday, May 16 at 8/7c, followed by Station 19 at 9/8c, on ABC.

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Grey's Anatomy Renewed for Season 16 and 17 at ABC

Physiology synonyms, physiology antonyms – FreeThesaurus.com

Physiology is an important branch of biology, its significance of study must be raised in Pakistan', Shahla Raza added.Shahana Urooj Kazmi while addressing at the panel discussion emphasized on the need of providing employment opportunities to physiology graduates in educational institutions especially varsities, 'MBBS students are preferred over them which is injustice', added the panellists.Stockholm [Sweden], Oct 2 ( ANI ): The Nobel Prize in Physiology or Medicine 2017 was awarded to three scientists Jeffrey C.This conference will go a long way to benefit of Physiologists with the modern developments in the subject of Physiology.The responses on various aspects of learning of physiology were acquired on a scale of poor, good or excellent.This article is being retracted at the request of the authors because of concerns about the accuracy of the initial data from the animal physiology laboratory at Duke University.2 days Seminar: Anatomy and Physiology and associatedTipton edits HISTORY OF EXERCISE PHYSIOLOGY (9780736083690, $119.It provides an international forum for the presentation of scholarly research findings and exchanges in exercise physiology and related areas of interest with global visibility.Human Anatomy, Human Physiology and Clinical Biochemistry are taught to the first phase medical students in their medical course.Sugarcane: Physiology, Biochemistry, and Functional BiologyContract Awarded for Develop BioGears , Army%s Human Physiology EngineThe third updated edition of Clinical Exercise Physiology provides college-level health and sports holdings alike with an in-depth examination of the clinical aspects of exercise physiology as it applies to chronic disease, and has been revised throughout to reflect the many changes that have affected the field.Prior to the same, he was working as Professor and Head (Academic & Research Co-ordination and International Co-operation), Veterinary Physiology, KVASU.Of particular interest in this book is a brief description of the origins of the Department of Physiology in the 1950s.

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Grey’s Anatomy’s Jesse Williams on That Huge MerLuca Moment …

Grey's Anatomy brought double the drama this week in a crossover with Station 19 that meshed together both worlds as Maggie (Kelly McCreary) took care of one of the firehouse's own.

Jesse Williams directed the first half of the two-hour event, titled "What I Did for Love," which saw Levi (Jake Borelli) help a man who had collapsed at a flower shop. But to Bailey's (Chandra Wilson) horror, John Doe turned out to be Fire Chief Luca Ripley (Brett Tucker), who works alongside her husband, Ben (Jason George). His predicament raised major concern, especially since he disappeared from his hospital bed just when Maggie concluded that his condition was worse than they initially thought. In the second hour, we learned that Ripley's efforts to find his fianc Hughes (Barrett Doss) and explain why he hadn't stood her up only made things worse for him. A combination of the toxins he inhaled from the last fire and a preexisting heart condition proved to be fatal, and the crossover ended with the Station 19 gang huddled around Hughes while she mourned the loss of her soulmate.

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Elsewhere, Jo (Camilla Luddington) experienced a huge emotional breakdown after a mixup with one of her patients, and Link (Chris Carmack) helped Levi understand what Nico (Alex Landi) was going through after losing a patient. In true Grey's fashion, the hour also tackled the delicate issue of immigration through Meredith (Ellen Pompeo), who treated a young girl whose family was seeking asylum. Realizing that her uninsured patient desperately needed medical attention even though her family had no way of paying for it, Meredith took drastic measures to ensure the girl receive the help she needed by falsely presenting her as her daughter Ellis on the insurance forms.

It was a bold move that could potentially cost Meredith her job, but it also served as the catalyst for a surprising moment with DeLuca (Giacomo Gianniotti). After a day of misunderstanding, DeLuca cleared the air with a heartfelt speech explaining why he remained silent throughout Meredith's ordeal. In awe of her courage, DeLuca revealed that he was afraid the only words that would have come out of his mouth would have been "I love you." But the question is, did he actually mean that or was he just caught up in the moment? Whether or not this was DeLuca's accidental declaration or just a slip of the tongue remains to be seen, but it clearly struck a nerve with Meredith, who immediately fled the room as soon as he finished talking.

TV Guide hit up Jesse Williams to break down the jam-packed episode, including what that unexpected MerLuca moment actually meant. Plus, Williams opened up about Jackson and Maggie's future together now that they've decided to move in together, and what it was like to tackle the topic of asylum given today's heated political climate.

This is your second time directing an episode of Grey's Anatomy. Stepping behind the camera means coming at the show from a different perspective. What new things did you learn about yourself while helming this episode?Jesse Williams: It's a little bit difficult to direct yourself. It's deciding whether to watch playback on every single take, whether I can see out of my own eyes what my fellow actors are doing, and taking in the scene. [It's] setting it up and then shooting it and just getting a rhythm and trusting your eyes versus making sure you've got all the pieces you've designed. It's a little bit tricky. It's certainly nice to have it be my second one. With the first one, I was certainly a bit more revved up and it was the great unknown. But once I knocked out my first one last year, I felt really comfortable during production and really loved the editing process, so I felt very very comfortable this time around.

What's the biggest difference between acting alongside your co-stars and actually directing them?Williams: It's a more fleshed-out vision as a director. Honestly, I pay more attention. I'm examining the scene tonally, visually, and literally in each character and taking in and considering all of their perspectives. As an actor, it's not my job to consider in the same way every other character's thought process because I want it to be alive and real and I want to listen. Acting is all about listening in the moment and reacting as opposed to directing, [where] I'm really responsible for where the couch cushions are, where everything is placed, how the lighting is set up, what the props are doing, what the art department is doing, what the medical is doing... It's a lot more. But I'm far more at home and I feel really comfortable as a director. And also with actors, I understand the language of how to communicate emotion and what it is you're asking of them without telling them what to do. That's such a collaborative medium and I certainly have a leg up by understanding an actor's language.

Jackson asked Maggie to move in with him and she tells him she needs to talk it out with Meredith before giving him an answer, which sort of confuses Jackson. He seems to view it as her asking for permission. Why did he react the way that he did?Williams: He kinda shoots from the hip and he knows what he wants when he wants it. With the mortality issue and his mom and feeling he could have lost her, I think he feels kinda more like live life to the fullest, trust yourself right now, just go for it. What happens to some people when they're faced with death or loss of a loved one, they start reconsidering being too careful and just live in the now.

In the end, Maggie decides to move in with Jackson, so what does that mean for their relationship moving forward?Williams: I think it means a lot. It's a very significant step forward. They had some hiccups. They had some issues. He took off for a little bit. He was trying to find himself and recalibrate what it means to be an adult and co-parent and move on after loving and losing someone. I think that makes it so they can't walk out on each other. They can't just go leave to get milk. They can't make excuses and go crash at Meredith's house. Like, this is it. You don't have an escape where after a fight you can just go sleep it off. You've gotta decide how to work this out tonight, and that's a very adult decision. For them, it's a very significant step because Maggie kind of likes to escape.

This episode was pretty big for MerLuca, with DeLuca telling Meredith he loves her for the first time. What do you remember in your conversations with Ellen and Giacomo about how to approach that scene and what was the most important thing you wanted to convey?Williams: Meredith had a hell of a day and had come in with momentum. She is misinterpreting his cues the whole day. He is genuinely and sincerely impressed by her audacity and confidence and she's taking it as critiques. She's taking it as doubt, so there is a miscommunication happening, which is fun to revisit. But she comes in hot and with a prescribed notion of like, "I know his position, I'm gonna address it. I'm gonna be brave and I'm just gonna tell him the truth." And the thing is, she got him wrong. And in that trying to stop the bleeding there, stop the momentum that she's developed, he kind of blurts it out. One of the things me and Giacomo [Gianniotti] talked about is, are you telling her you love her or are you telling her that all you could think about was saying you love her? It's kinda like saying you are a jerk or you're acting like a jerk. So when this comes out of his mouth, he knows how it sounds. He knows he didn't plan on saying it. He's not sure how she's taking it and then she shows us that she can't really handle this right now. It certainly has a comedic undertone, but it's a moment of letting the cat out of the bag. I'm not sure that he's sure that he meant it.

Grey's Anatomy is known for tackling tough topics and this episode delves into the matter of asylum with Meredith and her young patient. It's an important issue for so many people right now, so did you feel added pressure to get it right? What did it mean for you to tell this story?Williams: I took that storyline very seriously, and down to the casting. I made it very clear, as soon as I read it, that we're gonna cast brown people who look like those who are impacted. We're not gonna whitewash this and make it the palest Mexican or Central American you've ever seen, like the TV version of ethnicity. We're gonna cast people that are outstanding actors, and we found them with Omar [Leyva] and Allyson [Juliette]. I think a lot of that sometimes gets lost in a role with a heavy accent with folks that are brown, folks that are assumed to be just playing themselves, and that's not the case. This guy is a real thespian. But yes, I took the storyline very seriously because it's real, it's now, and we can't afford to distract from the real people living with these circumstances by adding too much hyperbole or flourishing in drama. Let's keep it centered and rooted in truth. It's very real to experience, unfortunately, and I think they did and will continue to do a great job of representing it.

We're getting close to the end of the season, so what can fans expect in the remaining episodes?Williams: I think we've bred a new level of amendment and frustration and decision making for Jackson and Maggie. It's one thing to talk about moving in together and it's another thing to do it, another thing to be trapped in close quarters with each other under stress. Without giving away too much, we'll really get to see how that pressure could bust pipes. I think we also get an understanding. ... I'm really excited about the Owen, Teddy, and Amelia triangle. We've got some really great scenes with them and that really develops. And we also have Camilla Luddington. Her role as Jo, she's just killing it this season. I can't say enough about how she's taking it to another level as a performer and how the hell she handles this avalanche of emotions and disappointment and heartbreak.

Grey's Anatomy airs Thursdays at 8/7c on ABC, followed by Station 19 at 9/8c.

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Grey's Anatomy's Jesse Williams on That Huge MerLuca Moment ...

Embryology – 9780702032257 | US Elsevier Health Bookshop

EMBRYOLOGY provides a concise and highly illustrated text, which confines its descriptions to those that are relevant for modern undergraduate and postgraduate medical courses, and similar courses in other related disciplines. An appreciation of embryology is essential to understand topological relationships in gross anatomy and to explain many congenital anomalies. Each chapter is supplemented by clinical point 'boxes' and by key revision points.Key Features

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Biochemistry: 9781464126109: Medicine & Health Science …

JEREMY M. BERG received his B.S. and M.S. degrees in Chemistry from Stanford (where he did research with Keith Hodgson and Lubert Stryer) and his Ph.D. in Chemistry from Harvard with Richard Holm. He then completed a postdoctoral fellowship with Carl Pabo in Biophysics at Johns Hopkins University School of Medicine. He was an Assistant Professor in the Department of Chemistry at Johns Hopkins from 1986 to 1990. He then moved to Johns Hopkins University School of Medicine as Professor and Director of the Department of Biophysics and Biophysical Chemistry, where he remained until 2003. He then became Director of the National Institute of General Medical Sciences at the National Institutes of Health. In 2011, he moved to the University of Pittsburgh where he is now Professor of Computational and Systems Biology and Pittsburgh Foundation Chair and Director of the Institute for Personalized Medicine. He served as President of the American Society for Biochemistry and Molecular Biology from 2011-2013. He is a Fellow of the American Association for the Advancement of Science and a member of the Institute of Medicine of the National Academy of Sciences. He received the American Chemical Society Award in Pure Chemistry (1994) and the Eli Lilly Award for Fundamental Research in Biological Chemistry (1995), was named Maryland Outstanding Young Scientist of the Year (1995), received the Harrison Howe Award (1997), and received public service awards from the Biophysical Society, the American Society for Biochemistry and Molecular Biology, the American Chemical Society, and the American Society for Cell Biology. He also received numerous teaching awards, including the W. Barry Wood Teaching Award (selected by medical students), the Graduate Student Teaching Award, and the Professor s Teaching Award for the Preclinical Sciences. He is coauthor, with Stephen J. Lippard, of the textbook Principles of Bioinorganic Chemistry.

John L. Tymoczko is Towsley Professor of Biology at Carleton College, where he has taught since 1976. He currently teaches Biochemistry, the Metabolic Basisof Human Disease, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry and co-teaches an introductory course, Energy Flow in BiologicalSystems. Professor Tymoczko received his B.A. from the University in Chicago in 1970 and his Ph.D. in Biochemistry from the University of Chicago withShutsung Liao at the Ben May Institute for Cancer Research in 1973. He then held a postdoctoral position with Hewson Swift of the Department of Biology atthe University of Chicago. The focus of his research has been on steroid receptors, ribonucleoprotein particles, and proteolytic processing enzymes. Gregory J. Gatto, Jr., received his A.B. degree in chemistry from Princeton University, where he worked with Martin F. Semmelhack and was awarded the Everett S. Wallis Prize in Organic Chemistry. In 2003, he received his M.D. and Ph.D. degrees from the Johns Hopkins University School of Medicine, where he studied the structural biology of peroxisomal targeting signal recognition with Jeremy M. Berg and received the Michael A. Shanoff Young Investigator Research Award. He then completed a postdoctoral fellowship in 2006 with Christopher T. Walsh at Harvard Medical School, where he studied the biosynthesis of the macrolide immunosuppressants. He is currently a Senior Scientific Investigator in the Heart Failure Discovery Performance Unit at GlaxoSmithKline. Lubert Stryer is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, where he has been on the faculty since 1976. He received his M.D. from Harvard Medical School. Professor Stryer has received many awards for his research on theinterplay of light and life, including the Eli Lilly Award for Fundamental Research in Biological Chemistry, the Distinguished Inventors Award of the IntellectualProperty Owners Association, and election to the National Academy of Sciences and the American Philosophical Society. He was awarded the National Medalof Science in 2006. The publication of his first edition of Biochemistry in 1975 transformed the teaching of biochemistry."

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Biochemistry – Methods in biochemistry | Britannica.com

Methods in biochemistry

Like other sciences, biochemistry aims at quantifying, or measuring, results, sometimes with sophisticated instrumentation. The earliest approach to a study of the events in a living organism was an analysis of the materials entering an organism (foods, oxygen) and those leaving (excretion products, carbon dioxide). This is still the basis of so-called balance experiments conducted on animals, in which, for example, both foods and excreta are thoroughly analyzed. For this purpose many chemical methods involving specific colour reactions have been developed, requiring spectrum-analyzing instruments (spectrophotometers) for quantitative measurement. Gasometric techniques are those commonly used for measurements of oxygen and carbon dioxide, yielding respiratory quotients (the ratio of carbon dioxide to oxygen). Somewhat more detail has been gained by determining the quantities of substances entering and leaving a given organ and also by incubating slices of a tissue in a physiological medium outside the body and analyzing the changes that occur in the medium. Because these techniques yield an overall picture of metabolic capacities, it became necessary to disrupt cellular structure (homogenization) and to isolate the individual parts of the cellnuclei, mitochondria, lysosomes, ribosomes, membranesand finally the various enzymes and discrete chemical substances of the cell in an attempt to understand the chemistry of life more fully.

An important tool in biochemical research is the centrifuge, which through rapid spinning imposes high centrifugal forces on suspended particles, or even molecules in solution, and causes separations of such matter on the basis of differences in weight. Thus, red cells may be separated from plasma of blood, nuclei from mitochondria in cell homogenates, and one protein from another in complex mixtures. Proteins are separated by ultracentrifugationvery high speed spinning; with appropriate photography of the protein layers as they form in the centrifugal field, it is possible to determine the molecular weights of proteins.

Another property of biological molecules that has been exploited for separation and analysis is their electrical charge. Amino acids and proteins possess net positive or negative charges according to the acidity of the solution in which they are dissolved. In an electric field, such molecules adopt different rates of migration toward positively (anode) or negatively (cathode) charged poles and permit separation. Such separations can be effected in solutions or when the proteins saturate a stationary medium such as cellulose (filter paper), starch, or acrylamide gels. By appropriate colour reactions of the proteins and scanning of colour intensities, a number of proteins in a mixture may be measured. Separate proteins may be isolated and identified by electrophoresis, and the purity of a given protein may be determined. (Electrophoresis of human hemoglobin revealed the abnormal hemoglobin in sickle-cell anemia, the first definitive example of a molecular disease.)

The different solubilities of substances in aqueous and organic solvents provide another basis for analysis. In its earlier form, a separation was conducted in complex apparatus by partition of substances in various solvents. A simplified form of the same principle evolved as paper chromatography, in which small amounts of substances could be separated on filter paper and identified by appropriate colour reactions. In contrast to electrophoresis, this method has been applied to a wide variety of biological compounds and has contributed enormously to research in biochemistry.

The general principle has been extended from filter paper strips to columns of other relatively inert media, permitting larger scale separation and identification of closely related biological substances. Particularly noteworthy has been the separation of amino acids by chromatography in columns of ion-exchange resins, permitting the determination of exact amino acid composition of proteins. Following such determination, other techniques of organic chemistry have been used to elucidate the actual sequence of amino acids in complex proteins. Another technique of column chromatography is based on the relative rates of penetration of molecules into beads of a complex carbohydrate according to size of the molecules. Larger molecules are excluded relative to smaller molecules and emerge first from a column of such beads. This technique not only permits separation of biological substances but also provides estimates of molecular weights.

Perhaps the single most important technique in unravelling the complexities of metabolism has been the use of isotopes (heavy or radioactive elements) in labelling biological compounds and tracing their fate in metabolism. Measurement of the isotope-labelled compounds has required considerable technology in mass spectroscopy and radioactive detection devices.

A variety of other physical techniques, such as nuclear magnetic resonance, electron spin spectroscopy, circular dichroism, and X-ray crystallography, have become prominent tools in revealing the relation of chemical structure to biological function.

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Cell-Biology | List of High Impact Articles | PPts …

Cell biology is a branch of biology that studies cells physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function. This is done both on a microscopic and molecular level. Cell biology research encompasses both the great diversity of single-celled organisms like bacteria and protozoa, as well as the many specialized cells in multicellular organisms such as humans, plants, and sponges. To know the components of cells and how cells work is fundamental to all biological sciences.

Related Journals of Cell Biology

Biochemistry & Analytical Biochemistry, Journal of Allergy & Therapy, Single Cell Biology, Journal of Bioterrorism & Biodefense, European Journal of Cell Biology, The Journal of Cell Biology, Journal of Molecular Cell Biology, International Journal of Cell Biology, BMC Cell Biology, Journal of Cell Biology and Genetics

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Cell-Biology | List of High Impact Articles | PPts ...

Immunology | ColumbiaDoctors

ColumbiaDoctors immunologists are dedicated to providing excellence in patient care for individuals with immunodeficiencies. Our specialists are highly trained and board certified in Allergy and Immunology. We treat the breath of immunodeficiency diseases, whether the cause is hereditary in nature or the result of another disorder. We are also affiliated with NewYork-Presbyterian, the top-ranked hospital in the tristate area.

Our central approach is to provide personalized and multidisciplinary medical care to patients, offering the latest insights to the rapidly advancing field of immunology. We utilize state-of-the-art measures to help diagnose and treat congenital immunodeficiencies and other immunological disorders... All of our academic faculty are nationally recognized clinical experts in immune-related diseases. Collaborating with infectious disease specialists, geneticists, and pathologists, we help patients with the most severe and rare immunodeficiency disorders.

Our patients directly benefit from the groundbreaking advances of the world-renowned Columbia Center for Translational Immunology (CCTI) that studies organ transplantation, hematopoietic cell transplantation, Type I diabetes, other areas of autoimmunity, tumor immunology, stem cell biology and basic immunology. CCTI is a research center aimed at bringing advances in basic immunology to patient care by gaining greater understanding of immune system. CCTI investigators have expertise at all levels of immunology and transplantation, from molecular biology to large animal and clinical transplantation studies.

Our specialists provide initial diagnoses, second opinions, immunologic testing, genetic testing as well as expert medical care. The initial comprehensive evaluation includes a thorough patient history, physical examination, and detailed review of previous records and test results.

These immunodeficiencies are usually present at birth and are hereditary. Though rare, they typically become evident during infancy or childhood but can become evident during adulthood. There are more than 100 different disorders such as humoral or cellular immunity. Examples include X-linked agammaglobulinemia, common variable immunodeficiency, and severe combined immunodeficiency, which is known as boy in a bubble disease.

We have offices at multiple locations, including Columbia University Medical Center on Broadway and W. 168th St and ColumbiaDoctors Midtown at 51 W 51 St.

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Immunology | ColumbiaDoctors