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Race, genetics and health: Our ancestry both limits and exacerbates … – Genetic Literacy Project

An Asian American born in Connecticut in 2009 could expect to live89.1 years. An African American, on the other hand, couldexpect to live 77.8 years. Its seldom surprising tosee large discrepancieswhen comparing life expectancies indeveloped and developing nations, considering the vast differences in availablehealth care. But how do we explain such a wide variance between two populations or ethnic groups living in the same region?

The complicated relationship between population, ethnicity and raceand how it impacts our health involves a complex equation offactors,includingmedicine,economics, psychology, anthropology, sociology andgeography. But it also seems clear that there are so-called race-related genetic factors in play .

Cultures and health behaviors

At this point in the history of medicine, there are a handful of behaviors withwell-established health impacts onour health. Among this is tobacco smoking,which has been linked unequivocallyto lung cancer and chronic obstructive pulmonary disease (COPD). Its also associated withcardiovascular and cerebrovascular conditions (leading to high blood pressure, atherosclerosis, heart disease, and strokes), and a host of non-pulmonary cancers. Yet different ethnic groups react differently to prolonged exposure.

Consider that therate of smoking among Native Americans is higher than for any other group in North America, at 26.1 percent, according toAmerican Lung Association. At the other end of the smoking spectrum areAsian Americans, at 9.6 percent, andHispanics at12.1 percent. In the middle areAfrican Americans, 18.3 percent, andCaucasians,19.4 percent.

Source: American Lung Association

Based on smoking rates alone, youd expect Asians and Latinos to have lower lung cancer rates, and they do. However, youd also expect Native Americans to have higher lung cancer rates. Yet their lung cancer rates are only slightly worse thanthose of Latinos. Strikingly, the ethnic group with the highest lung cancer rate is African Americans, according to the Center for Disease Control (CDC).

A similar phenomenon is seen inalcohol use. According to the National Institute of Alcohol Abuse and Alcoholism (NIAAA), the most common drinkers are white males, 74.27 percent, while Asian-American women were the least common, at 36.11 percent. In terms of daily heavy drinking, the highest rates were recorded among Hispanic males, at 40.48 percent, while Asian American men had the lowest rate, at 18.84 percent. Alcohol abuse relates to liver disease, nutritional disorders, and various cancers, but as with smoking the disease rates among ethnic groups do not correlate precisely with consumption.

Black men (25.81 percent)and women (19.02 percent), for example, reported lower rates of daily heavy drinking, when compared to white men and women. Yet, African Americans have a higher risk of developing alcohol-related liver disease, according to the National Institutes of Health.

Health genetics

With majorkillers like heart disease and stroke,there are a multitude of genetic factors, making forcomplex relationships between genetics and disease.For example, despite having a relatively high risk of developing cardiovascular disease, Latinos have alower risk of actually dying from the disease. Thus, studies are constantly underway to examine genetic risk factors and markers. African Americans have a notoriously high rate of high blood pressure compared with other ethnic groups, and for decades there has been a debate regarding whether genetic factors or environmental factors are more important.

What about discrimination?

A potentially troubling possibility has emerged from a University of Florida study that was published in December 2016in thejournal PLOS ONE. By interviewing 157 African American subjects in creative ways, researchers were able to show a relationship between the feeling of discrimination and high blood pressure. The study pointed toeight genetic variants of five genespreviously known to be associated with cardiovascular disease. The cause ofhigh blood pressure iscomplex, given that its related both to physical phenomena such as factors controlling how tightly blood vessels squeeze, as well as psychological factors, since blood pressure rises in nearly everyone when they become anxious or stressed.

Putting all of these factors into a coherent picture of how diseases are generated appears to be a daunting task. Year by year, month by month, the science community is inundated with new data, especiallyfrom genomic studies. Various new instruments are in use too, and yet, when the goal is to assess anything related toethnicity or race, the task grows progressively more difficult.

David Warmflash is an astrobiologist, physician and science writer. Follow @CosmicEvolution to read what he is saying on Twitter.

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Race, genetics and health: Our ancestry both limits and exacerbates ... - Genetic Literacy Project

Lab opens doors for an undergrad experience – Harvard Gazette

For most college freshmen, working in a lab typically means following the step-by-step instructions of class assignments with the goal of performing a specific experiment to produce a predetermined result.

But a handful of Harvard freshmen got the chance to experience real lab work by exploring how altering genes in yeast affected the cells functions.

Created by postdoctoral fellow James Martenson and Vlad Denic, a professor of molecular and cellular biology, the Wintersession class was designed to give undergraduates an up-close-and-personal view of the research that takes place in Harvard labs, and the opportunities they have to take part.

Students often arent aware these opportunities exist, so we think of this as a gateway for freshmen interested in doing research, Martenson said. But we also wanted to emphasize some of the critical thinking skills we use every day as scientists, but which may not be emphasized as much in more traditional coursework.

Over the course of the multiday class, each student worked with genetically altered strains of yeast to perform a series of three experiments.

We chose yeast because its a classic model organism in biology, Martenson said. A lot of very important work has been done in yeast. In fact, much of what we know about basic cell biology weve learned from yeast.

Using their various strains, he said, students performed a series of experiments aimed at testing how genetic changes altered organelle function.

A critical part of cell biology, organelles are essentially compartments inside cells, and include everything from mitochondria which act as the cells power plants to nuclei, which contain genetic material.

One key question in cell biology is how organelle quality is maintained, because many organelles house toxic chemical environments, Martenson explained. You also need a way to ensure the organelles are healthy, and if they do get sick, they need to be identified and eliminated before they cause a problem for the rest of the cell.

To probe questions of organelle health, Martenson is focusing on an organelle called the peroxisome and students did the same.

We started with a list of genes we had reason to believe were important for peroxisome function and quality control, but which were uncharacterized, he said. We thought it would be interesting for students to be involved in something that were actually interested in studying, so their work could yield interesting results that could inform our research.

For the students who took part, the experience was invaluable.

I didnt have a lot of lab experience, and I felt this class was a good way to expose myself to it, said Dylan Rice. I feel like Ive learned a lot, and Ive really enjoyed it so far.

Though she had already worked in another lab, Irla Belli said the relaxed atmosphere of the class helped her learn that making mistakes is often a key part of research.

You learn a lot from them, she said. In this four-day span, Ive learned more than from all the labs I had in class. This has solidified my desire to pursue the Ph.D. part of an M.D./Ph.D, and even though its very serious science, its relaxing.

For Amanda DiMartini, the class was a chance for an in-depth look at a field shes considering as a concentration.

I did some research in high school, but it was relatively simple, she said. Im interested in concentrating in some area of biology and this was a chance to see if I want to continue doing research throughout college. I feel like, in this class, were learning to think scientifically, and to think critically, and how to do research at a higher level. I dont regret [this class] at all.

By Colleen Walsh, Harvard Staff Writer | February 16, 2017

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Lab opens doors for an undergrad experience - Harvard Gazette

SSCI Expands Biochemistry Services to Meet Growing Industry … – Benzinga

Intended to meet rapidly growing needs of the biopharmaceutical sector

WEST LAFAYETTE, Indiana (PRWEB) February 16, 2017

SSCI, a division of Albany Molecular Research Inc. has further extended its industry leading Biochemistry Services specifically targeting the rapidly growing needs of the biopharmaceutical sector. This service offers state-of-the-art cGMP techniques and methods for the biochemical and biosimilar characterization, product-related impurity characterization, aggregation state characterization, structure elucidation, protein formulation development, comparability, analytical method development and validation, and protein and peptide crystallization. Included in the diverse array of services available, an ultra-high resolution Q-TOF mass spectrometry is the cornerstone a state of the art instrument that significantly enhances SSCI's capabilities in analysis and data interpretation for large molecules, including biologic drugs such as antibodies and antibody-drug conjugates, metabolites and polymers to meet the expectations outlined in the ICH Q6B Specifications: Test Procedures and Acceptance Criteria for Biotechnological/ Biological Products.

"Innovative proteins and biopharmaceuticals comprise the fastest growing class of new chemical entities in the industry," commented Patrick Tishmack, PhD, Director Analytical Development , who leads the Biochemistry Services at SSCI. "Many of these therapeutic proteins typically exist in the solid state as lyophilized powders during their manufacture or in a final formulation. Few proteins are produced as crystals or formulated as mixtures of crystalline and amorphous protein. Therefore, SSCI is uniquely positioned to provide an understanding of the properties of biologics in the solid-state or as liquid formulations, which is of critical importance both in the development of the product and for regulatory approval."

About SSCI SSCI, a division of Albany Molecular Research Inc., provides industry leading contract solid-state and analytical testing services and exists to help companies in the pharmaceutical, food, agrochemical, and other chemical industries develop better products and get them to market more quickly. Over the past quarter century, SSCI has provided comprehensive cGMP research and analytical services in the characterization and chemistry of solid materials, with particular expertise in small and large molecules being investigated for pharmaceutical use. As the AMRI's Center of Excellence for Solid State Chemistry, its offerings include early candidate support services (in vitro analysis, stability, solubility, dissolution, excipient compatibility), solid form screening and polymorph, salt and cocrystal screening, form selection, particle engineering (process development, particle size method development), property improvement, crystallization of difficult materials, process control, biochemical analysis, full analytical chemistry support including method development and validation, intellectual property consulting and litigation support, and related research activities.

For more information about SSCI's biochemistry services, please contact 1-800-375-2179 or visit http://www.ssci-inc.com.

For the original version on PRWeb visit: http://www.prweb.com/releases/2017/02/prweb14066531.htm

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SSCI Expands Biochemistry Services to Meet Growing Industry ... - Benzinga

Doctors call for revising syllabus of anatomy – Times of India

NAGPUR: Various issues on revision of anatomy syllabus, including assessment of manpower and duration of teaching, came up for discussion during a conclave organized by the department of anatomy of NKP Salve Institute of Medical Sciences and Research Centre recently.

The topic of the conclave was 'Challenges in anatomy curriculum and way ahead.' Dr DD Ksheersagar was the organizing secretary. Ninety-two delegates from Central India participated in the continuing medical education (CME) programme and discussed various issues on revision of the syllabus of anatomy that also highlighted modification in theory, practical examination, curricular reforms for histology, embryology, gross anatomy and genetics.

Dr Mangala Kohli, head of the anatomy department, Vardhaman Mahavir Medical College, New Delhi, was the chief guest. Dr MD Huddar introduced Dr Kohli. Dr Ksheersagar welcomed the chief guest and other dignitaries and explained the purpose of holding the CME. Dr Kohli stressed the need for reforms in anatomy curriculum and improving job opportunities for anatomists. Ranjeet Deshmukh, chairman of VSPMAHE, congratulated Dr Ksheersagar for organizing the CME.

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Doctors call for revising syllabus of anatomy - Times of India

‘Grey’s Anatomy’ Star Sara Ramirez Calls Out ABC for ‘Biphobia … – Entertainment Tonight

Sara Ramirez is calling out her old network.

The 41-year-old actress, who starred for 10 years on ABC's Grey's Anatomy, took to Twitter on Thursday to slam the network for a joke about bisexual people that aired during a recent episode of The Real O'Neals.

WATCH: 'Grey's Anatomy' Star Sara Ramirez Comes Out as Bisexual

On the episode in question, which aired on Jan. 17, Noah Galvin's openly gay character, Kenny, compared being bisexual to having "webbed toes" or "money problems."

Ramirez, who played bisexual character Callie Torres on Grey's, and identifies as bisexual herself, said that she was "truly disheartened and disappointed" by the joke, and that she would "invest my brand where I'm respected."

The actress addressed ABC and The Real O'Neals in her tweet, encouraging them to "own" and "address" the mistake, to "empower our #Queer and #Bisexual youth & community w/accurate positive reflections." She also asked fans to sign a Change.org petition imploring ABC to "end biphobia and bi-erasure" on the comedy.

WATCH: Shocker! 'Grey's Anatomy' Star Sara Ramirez Exits Show After 10 Seasons

In another tweet, Ramirez reacted to Galvin's response to the joke, saying it "wasn't enough for me."

RELATED: 'Real O'Neals' Star Noah Galvin Slams Colton Haynes, Eric Stonestreet & More, Immediately Apologizes for 'Hurtful' Comments

The Real O'Neals star, who found himself surrounded by controversy last year after slamming Eric Stonestreet's portrayal of a gay man on Modern Family and mocking Colton Haynes' decision to come out as gay, addressed the joke last month on Twitter.

The 22-year-old actor said he "respects and loves the bi community," though defended the joke, saying it represented "a panicky teen expressing his 'deepest fear' which was his boyfriend leaving him for a girl." "I'm sorry if we offended anyone. I hope you know our show fights for visibility and inclusivity and we will do better in the future. BUT, we also have to remember, it's a comedy."

WATCH: 'Greys Anatomy' Boss Addresses Sara Ramirez's Exit: 'I Had a Different Plan'

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'Grey's Anatomy' Star Sara Ramirez Calls Out ABC for 'Biphobia ... - Entertainment Tonight

Listen to this male snow leopard’s love song in the Eastern Sayan … – The Siberian Times

Many people still believe that these large secretive cats can't roar due to the physiology of their throat. Picture: Following Snow Leopard Volunteers Expedition

Spotted by a camera trap in the Republic of Buryatia, this snow leopard has debunked the 'no roar' theory about snow leopards, says a leading Russian authority on the wild animals.

Dmitry Medvedev, president of the Irklutsk-based Snow Leopard Foundation, says the mating season cry is proof.

'Many people still believe that these large secretive cats can't roar due to the physiology of their throat, unlike lions, tigers and leopard,' he said.

'This video proves that they can. It shows a large male roaring loudly during a mating season high in the Eastern Sayan mountains.'

Listen to this male snow leopard's love song in the Eastern Sayan mountains.Pictures: Gazeta Pskov, Dmitry Medvedev

The video which hasn't been previously shared was filmed in March 2014 near the snow leopard research base in Buryatia, and won a video trap competition for cats in 2016.

Website snowleopard.org says the endangered animals 'make sounds similar to those made by other large cats, including a purr, mew, hiss, growl, moan, and yowl.

'However, snow leopards cannot roar due to the physiology of their throat, and instead make a non-aggressive puffing sound called a 'chuff'.'

Yet the sound on this video seems more than a 'chuff'.

Endemic to high and rugged mountains in southern Siberia and central Asia, scientists estimate that there may be as few as 3,920 snow leopards left in the wild.

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Listen to this male snow leopard's love song in the Eastern Sayan ... - The Siberian Times

Salivary salt modifies cheese’s tang – Chemistry World (subscription)

If your Christmas was anything like mine, then you ate an awful lot of cheese. I love mature cheddar, and Im partial to brie, but dont offer me anything blue. I always thought my taste buds dictated my choices but recent research has shown that your physiology can affect how you perceive food.

To test for a link between physiology and taste, Elisabeth Guichard from the French National Institute for Agricultural Research, and colleagues combined cheddar, soft cheese, butter, protein powder, salt and water in different proportions to create four model cheeses with differing fat content and firmness. They then trained 14 taste testers to recognise the odour of two specific compounds nonan-2-one, which gives blue cheese its notable smell, and ethyl propanoate, which gives cheese a fruity odour and rate their perception of these two compounds in the cheese they tasted. At the same time the researchers recorded the testers chewing activity and saliva composition.

Chewing mixes food with saliva. During this step, aroma compounds within the food transfer to the saliva and are then released into the nasal cavity. It is already known that food texture and composition will affect this aroma compound release. What Guichard has now discovered is that saliva composition plays a role as well. The aroma of cheeses is perceived differently by humans due to differences in their salivary composition and the way they process the cheese in their mouth. Humans with a low salt content in saliva and high lipolysis [the ability of the body to break down fats in the cheese] activity perceived the cheeses as being more salty, more cheesy and less fruity, says Guichard.

Flavia Gasperi, head of the sensory quality research group at the Edmund Mach Foundation in Italy, agrees with Guichard that both chemical and physiological parameters can influence a foods perceived quality. The highlight of this study is that the researchers are not scared, as often happens, by the complexity of this interaction between food and consumer. They successfully take into account different aspects of food composition and texture, but also the physicochemical and cognitive mechanisms related to the subjects responses, says Gasperi.

Taste perception can also change with time, as eating salty foods alters saliva composition over the course of a day and sense of smell decreases with age. This research could help the food industry tailor their products to the physiology of specific populations. So maybe one day I will like blue cheese, but for now, just pass me the cheddar.

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Salivary salt modifies cheese's tang - Chemistry World (subscription)

Neuroscience firm plots Barnsley expansion – Insider Media

One of the UK's largest neuroscience research companies is to open a new site in Barnsley this month, creating 12 jobs.

MAC Clinical Research, which has operations in Manchester, Leeds, Blackpool, Cannock and Liverpool, specialises in clinical trials for Alzheimer's disease, diabetes, osteoarthritis, eczema, psoriasis, central nervous system conditions and depression.

It currently employs a workforce of 150.

Now, it is moving into 4,800 sq ft office space at Wentworth Office Park.

MAC has invested 500,000 in the site and has been supported by Enterprising Barnsley, the business development arm of Barnsley Council.

Dr Mark Dale, chief executive of MAC Clinical Research, said: "The move into Barnsley is a natural expansion for us and will see us get more heavily involved in the South Yorkshire market.

"In the not too distant future, we're looking to open up more research sites across Yorkshire."

Martin Beasley, Enterprising Barnsley group leader, added: "MAC Clinical Research is now starting to get the staff in place to become fully operational. We wish them all the best and look forward to working with them in the future."

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Neuroscience firm plots Barnsley expansion - Insider Media

Optogenetics: What Makes It a Powerful Neuroscience Tool? – Labiotech.eu (blog)

Its a brand-new field and possibilities seem infinite. Heres what you need to know about its rapid development intoa powerful genetic tool.

What if you could activate and deactivate neurons by simply switching on the lights? Thats the basis of optogenetics, the control of cell behavior via light-sensitive proteins.

Optogenetics is a very young field, thought to have started back in 2002, which has significantly grown over the last decade. Since then, it has been explored as a method to restore eyesight, to treat arrhythmiaand toprecisely control the growth ofbacteria.

But one of the areas where it presents more potential is neuroscience. The technology allows for the control of specific neurons in living animals and monitoring the effects in real time. It can be used to preciselymap brain circuits responsible for a particular behavior, such as fear or drug addiction, and as a therapy for neurological diseases like epilepsyor Parkinsons. Neurons can be easily controlled using a method that is fast, with responses at the millisecond scale, reversible and cell specific.

As it name indicates, optogenetics relies on genes to introduce light-sensitive proteins in specific cells. These proteins are most commonlyopsins, membrane proteins that transform optical input into electrochemical signals within the cell. These proteins can be found in the retina, but those used in optogenetics are typically of microbial originbecause they have a simpler structure and transmit signals faster.

When the opsin is excited, it induces the exchange of ions across the membrane, changing its potential and either activating or inhibiting neuronal activity. The fast reaction time of the proteins allows a researcher to test how different frequencies in the light pulses affect behavior. And since different opsins are excited by light atspecific wavelengthsit is possible to combine several of them in a single animal.

The possibilities seem unlimited, butfor the technique to work properly, efficient delivery and expression of opsin genes to the target neuronsare critical.

Lentiviral vectors are one of the tools of choice for genetic engineering in optogenetics. Viral vectorstake less effort and time than creating transgenic lines. And among them, lentiviral vectors have a larger capacity, which allows including several elements, such as largepromoter andreporter genes, in the final construct.

Here is where GEG Tech comes in. The French company has an extensivecatalog of lentiviral vectors to choose from, with a big selection for optogenetics applications. Its scientists have edited and created lentiviral vectors with different features to match the needs of any particular application. For example, theycan control if gene expression is eithertransient or long-term and whether the genetic material is integrated into the host, as well as include multiple promoters and reporters. And if aclient needs another promoter or another reporter, GEG Tech will design a customized new lentiviral vector.

The company also offers help for lentiviral vector users through explanatory videos, online protocols and extensive information on the properties, safety and regulations concerning the genetic tools. If you want to know more, pay a visit to GEG Techswebsite!

Despite being a very young field, optogenetics is alreadystarting to make noise in the biotech industry. Well bring you the latest news as more and more applications of the technology emerge in coming years.

Images from Sergey Nivens /Shutterstock; Biological Psychiatry (2015) 71, 12;Deisseroth K. et al.; 2015; GEG Tech

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Optogenetics: What Makes It a Powerful Neuroscience Tool? - Labiotech.eu (blog)

Sitting Is Deadly. Could Banning Chairs Help? – Co.Design (blog)

By now the health deficits of sitting all day are so widely studied and well-documented that they're impossible to ignore. Studies show that sitting increases lower back pain, slows our metabolisms, and shortens our life-spans, among a host of other things. Not even daily exercise is enough to offset the damage. What's a health-conscious person to do?

The End of Sitting. [Photo: Ricky Rijkenberg via RAAAF]

One answer: Eliminate chairs altogether. At the interdisciplinary Dutch design studio RAAAF (Rietveld Architecture-Art-Affordances), brothers and cofounders Ronald and Erik Rietveld have been studying how radically redesigning the workplace and home might affect how sedentary we are. Their installations The End of Sitting, which debuted in 2014, and Breaking Habits, opening at the Mondriaan Fund for Visual Arts in Amsterdam February 16, present chair-free environments that encourage people to get up and move. As Erik puts it, "As long as there are chairs present, people will sit in them habitually."

Though grounded in scientific research, the Rietveld's installations are mostly conceptual; they're about researching how we can manipulate an environment's design to impact sedentary behavior. But they bring up an interesting idea: What if we did banish chairs altogether? Is that even possible? And would that solve our societal sitting problem, or just open up the door to new problems?

The design of the structures in the Rietveld's project are the result of years of research and a series of experiments. Ronald is a practicing architect, and Erik is a philosopher, whose research project "The Landscape of Affordances: Situating the Embodied Mind," funded by the Netherlands Organisation for Scientific Research (NWO), forms the basis for the design work. The pair's research revolves around the scientific concept of affordancesput simply, the idea that human behavior is learned by picking up the information that is relevant to survival, and ignoring the rest. Throughout history, trees have afforded climbing on, for example, and holes have afforded hiding in. And for centuries in Western society, chairs have afforded sitting in. The easiest ways to change human behavior is to radically change our surrounding environment.

Working together, Erik and Ronald have taken the idea of affordances and applied it to the prospect of a chair-less and table-less future. "The easiest ways to change human behavior is to radically change our surrounding environment," says Erik. Three years ago, the studio reimagined the office as a labyrinth of concrete and plywoodwithout traditional desks or chairsfor The End of Sitting. In Breaking Habits, they expanded the scope to include the home, with a futuristic and surreal "domestic landscape."

The cut-away office space in The End Of Sitting structure was rigid and confining. Based on feedback from participants in a study they conducted in the installation, the Rietvelds determined that softer material would make the act of not sitting more comfortable. As a result, the new installation is made from large swaths of carpet-like materiala proprietary mix of wool threads and a felt basethat are draped over stainless-steel rollers suspended from the ceiling.

In Breaking Habits, the spareness of the environment eliminates more than just chairs: There are no desks on which to put a laptop, thereby discouraging sitting and working at home. There are no hard surfaces for a TV to watch Netflix from bed. Visitors to the installation are invited to use the spaceto interact with it, and to lean, stand, or lie against the soft surfaces. In turn, the Rietvelds will observe those interactions in an informal manner. They also invite behavioral scientists to bring study groups to the installation, and use it as a place for more formal scientific study on how people might use and adapt to this type of new environment. (Though no scientific studies are scheduled at the moment, the Rietvelds say the Mondriaan Fund appears open to letting scientists use the space in that way.)

Breaking Habits

RAAAF's futuristic landscapes aren't necessarily homey and comfortable, but they aren't supposed to be. They are meant to explore new possibilities for our spaces, not represent the exact blueprint of our house.

One of the most important aspects of RAAAF's experimental environments is that they encourage the user to shift positions frequently. In Breaking Habits, for instance, some pieces of fabric are configured into pyramids or perpendicular walls on which to lean; others are suspended like a hammock for lying down on when your legs muscles inevitably get tired. The goal was "temporary comfort, not permanent comfort," says Ronald.

This idea addresses one of the main health risks of sitting: the slow-down of our metabolism. When we sit for a prolonged amount of time, our skeletal muscles remain inactive and the metabolic pathways linked to these muscles that regulate how we store fats and break down sugars become less efficient. Moving around, stretching, oscillating between standing up and sitting back down againthese are things that scientists recommend to help combat the onset of metabolic-related diseases like type 2 diabetes, some cancers, and heart disease. The rungs hanging from the ceiling and the more flexible landscape in Breaking Habits were built to aid and allow for stretching, the brothers say, and since leaning against fabric is only comfortable for so long, moving around is also a necessity.

According to Avi Biswas, PhD candidate at the Institute of Health Policy, Management, and Evaluation at the University of Toronto (who was not involved in the RAAAF project), the way environments are designed can make a significant difference in offsetting the metabolism slow-down. Biswas, whose post-doctoral work (he defends his dissertation at the end of the month) will focus on the influence of the workplace environment on sedentary behavior of workers, says that any place that encourages you to get up, take a walk, and move around is helpful in slowing down the health risks of sitting.

However, he also notes that not all movement is created equal: Tasks that require exerting more energy will burn more calories, and will have the greatest effect on your metabolism. In that regard, merely shifting positions is not as helpful as, say, taking a lap around the office. It's the same way that having a standing desk is beneficial, but not quite as much so as walking on a treadmill while working. Ultimately, we need to both exercise and move more to remove the risks of sedentary behaviorand while RAAAF's installations do encourage movement, they don't necessarily guide people in exerting the kind of energy that would be most helpful in counteracting slowing metabolisms.

The End of Sitting [Photo: Jan Kempenaers via RAAAF]

So eliminating chairs won't automatically get us to exercise, but will it encourage us to invent other resting positions out of necessity? And if so, will those positions be better than sitting?

From a behavioral perspective, people interact with the environment that we are exposed to, says Lucas Carr, an assistant professor and director of the Behavioral Medicine Lab at the University of Iowa (who is also uninvolved with RAAAF's project). But even without chairs, "humans are still going to rest for long periods of time," says Carr. "It's how we were designed."

So eliminating all chairs without replacing them with better resting options simply wouldn't work. Just like sitting all day is bad for your health, standing for too long is unhealthy, too. It causes fatigue and blood begins to pool in the legs, among other things. And leaning against something isn't necessarily much better.

As Carr points out, prior to being conditioned to sit still in chairs for long periods of time, young children instinctively sit in more natural resting positions that include sitting on their heels, sitting cross-legged, and sitting in a squatting position. The latter is an effective middle ground between standing and sitting, and it's actually a position that Carr would still recommend todaythough he acknowledges it's not a position most people want to take in public. (As a sidenote, Carr says he doesn't know of any products or environments that would normalize or support that position, but suggests it's an area that might be helpful if designers explored.)

Meanwhile, Breaking Habits gives designers something to mull over between now and 2025, the year that RAAAF set for its futuristic home. Our living rooms may never look like the installation, but it wouldn't hurt to drape a few carpets and get serious about chair alternatives just in casethe best way to kick a bad habit is to replace it with a good one.

Slideshow Credits: 01 / Photo: Jan Kempenaers via RAAAF; 02 / Photo: Jan Kempenaers via RAAAF; 03 / Photo: Jan Kempenaers via RAAAF; 04 / Photo: Ricky Rijkenberg via RAAAF; 05 / Photo: Ricky Rijkenberg via RAAAF;

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Sitting Is Deadly. Could Banning Chairs Help? - Co.Design (blog)