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Three parent baby born in UK hospital | Business Recorder – Business Recorder (press release) (registration) (blog)

Baby parented by three individuals, was given birth this Thursday in a UK hospital, the very controversial technique was legalized by the parliament in December, in attempts to thwart inherited diseases.

According to the Huffington post, the technique was not taken ahead by the doctors at the Newcastle Fertility Centre until the individual parent agreed on it.

This significant decision represents the culmination of many years hard work by researchers, clinical experts and regulators," said Sally Cheshire, head of the human fertilization and embryology authority.

"Patients will now be able to apply individually to the HFEA(Human Fertilization and Embryology Authority) to undergo mitochondrial donation treatment at Newcastle, which will be life-changing for them, as they seek to avoid passing on serious genetic diseases to future generations," she said.

The human cell comprises of two DNA structures, one is nuclear DNA which is present in the nucleus of cell and the other DNA is mitochondrial DNA which is present in the cytoplasm of the cell. Unlike the nuclear DNA which is inherited half from mother and half from father, the mitochondrial DNA is inherited only from the mother that has been a source to some inherited disease affecting 1 in every 5000 births. This technique allows replacing the defected mitochondrial DNA with a perfect one minimizing the possibilities of the disease.

Many years of research have led to the development of pronuclear transfer as a treatment to reduce the risk of mothers transmitting diseases to their children, Mary Herbert, a professor of reproductive biology at Newcastle Fertility Centre and Newcastle University, said in a statement. Its a great testament to the regulatory system here in the UK that research innovation can be applied in treatment to help families affected by these devastating diseases.

This is an invitro-fertilization technique that requires the pronuclei the nucleus of the sperm and the egg during the process of fertilization from an embryo containing the mothers unhealthy mitochondria. These pronuclei are then inserted in a donor embryo containing healthy mitochondria, stated in Rawstory Post.

The baby with this technique will have a genetic makeup from all three parent, one male and two mothers.

A Jordanian couple was the first to parent a baby born through this technique in Mexico, which was led by a team of U.S. doctors, the reason for using this technique was to avoid Leigh Syndrome a neurological disorder that is transferred by the mothers mitochondria and is fatal in early childhood.

The techniques were also opposed by UK churches on both ethical and psychological grounds.

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New drug strategy: Target ribosome to halt protein production – UC Berkeley

The discovery of a chemical compound that halts the production of a small set of proteins while leaving general protein production untouched suggests a new drug search strategy: Find compounds that target undesired proteins before they are even made.

Ribosomes lined up along pieces of messenger RNA extrude proteins that curl up once they emerge from the ribosomes internal tunnel. UC Berkeley and Pfizer scientists discovered that a small molecule (black T) can kink the growing protein inside the tunnel and stall its production while leaving other protein production unaffected. Jamie Cate image.

Many of todays therapies for cancer or heart disease are monoclonal antibodies that bind and disable proteins outside the cell. The immunotherapeutic checkpoint inhibitors, such as Yervoy, block suppressor proteins, for example, unleashing the immune system to attack cancer.

But monoclonal antibodies arent effective against all proteins, cant enter cells and must be delivered via injection.

In a paper appearing today in the journal PLOS Biology, researchers at the University of California, Berkeley, and Pfizer Worldwide Research and Development report finding a small molecule that was able to block the production of a specific protein involved in LDL (low-density lipoprotein) turnover by stalling only the ribosome that produces that protein. Ribosomes are large, general-purpose molecular machines that translate genetic instructions in the form of messenger RNA into the proteins used to build cells, the enzymes in charge of cellular housekeeping, and the hormones that carry messages in and between cells.

When delivered orally to rats, the small molecule lowered LDL cholesterol levels, much the way statins do, though by a different mechanism: by lowering the production of the protein PCSK9.

While antibiotics like erythromycin are known to stall the ribosome, they halt production of most proteins, said Jamie Cate, one of two senior authors, a UC Berkeley professor of molecular and cell biology and of chemistry and a faculty scientist at Lawrence Berkeley National Laboratory.

The chemical in this instance stalls the ribosome only when its producing the protein PCSK9 and a couple of dozen others out of the tens of thousands of proteins the body produces, as shown by a relatively new technique called ribosomal profiling.

PCSK9 was just where we started. Now we can think about how to come up with other small molecules that hit proteins that nobody has been able to target before because, maybe, they have a floppy part, or they dont have a nook or cranny where you can bind a small molecule to inhibit them, Cate said. This research is saying, we may be able to just prevent the synthesis of the protein in the first place.

Cate suspects that the small molecule in the current study, a multi-ringed chlorinated compound, could serve as a template, like a key blank that can be machined to open a specific lock.

We now have this key blank that we can cut in a number of different ways to try to go after undruggable proteins in a number of different disease states, Cate said. No one really thought that would have been possible before.

Stalling the ribosome The small molecule was discovered by Pfizer labs through live-cell screening for compounds that lower production of the protein PCSK9 (proprotein convertase subtilisin kexin 9), which regulates the recycling of the LDL receptor. Knocking out the protein is known to lower blood levels of LDL cholesterol, the so-called bad cholesterol, presumably lowering risk of cardiovascular disease. PCSK9 inhibitors, mostly monoclonal antibodies, actually lower LDL better than the well-known statins, though they have to be injected into the bloodstream.

When it became clear that the chemical was acting on the ribosome, Spiros Liras, vice president of medicinal chemistry at Pfizer, approached Cate and Jennifer Doudna, both leaders in the field of ribosome function and translation, to establish a collaboration through UC Berkeleys California Institute for Quantitative Bioscience (QB3) to further investigate the questions of selectivity and mechanism of action. Cate is also director of UC Berkeleys Center for RNA Systems Biology, while Doudna is a professor of molecular and cell biology and of chemistry, a Howard Hughes Medical Institute investigator and executive director of the Innovative Genomics Institute.

Pfizer brought a significant depth of knowledge and resources to the collaboration, including fundamental cell biology, disease-relevant expertise, chemical biology and medicinal chemistry,said Liras. We aimed at building a strong cross-institutional collaboration which would complement our strengths in drug discovery with UC Berkeleys strengths in ribosome biochemistry and structural biology.

In the PLOS Biology paper, Cate, Robert Dullea at Pfizer and their teams at UC Berkeley and Pfizer describe how the drug interacts with the ribosome to halt protein production.

According to Cate, the ribosome assembles amino acids into a chain inside a tunnel that holds about 30 to 40 amino acids before the end begins to poke out of the tunnel. The chemical studied appears to bind to specific amino acid sequences of the growing protein within that tunnel in the ribosome and make them kink enough to stop progress down the tunnel, halting protein synthesis.

We found that the proteins that are stalled are too short to stick outside the ribosome, Cate said. So we think the compound is actually trapping this snake-like chain, the starting part of the protein, in the tunnel not completely blocking the tunnel, but just partially blocking it, in a way that prevents this particular protein from making its way out.

While its still unclear what the two dozen proteins affected have in common that makes them susceptible to stalling by the small molecule, Cate sees these findings as clear evidence that ribosomal stalling can occur very specifically, something most researchers thought unlikely.

We think that we now have enough understanding of the mechanism that we have our foot in the door to explore the relevance of this biology more broadly, said Cate.

Co-authors of the paper are Cate, Doudna and postdoctoral scholar Nathanael Lintner of UC Berkeley and Pfizer researchers Kim McClure, Donna Petersen, Allyn Londregan, David Piotrowski, Liuqing Wei, Jun Xiao, Michael Bolt, Paula Loria, Bruce Maguire, Kieran Geoghegan, Austin Huang, Tim Rolph and Spiros Liras.

The work was funded by Pfizer, with computing and gene sequencing assistance through resources supported by the National Institutes of Health. RELATED INFORMATION

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New drug strategy: Target ribosome to halt protein production - UC Berkeley

Vacancies at AIIMS, Jodhpur for 48 Junior Resident and Tutor/Demonstrator (Biochemistry) Posts – Jagran Josh

All India Institute of Medical Sciences, Jodhpur Jobs Notification: All India Institute of Medical Sciences, Jodhpur invited applications for the post of Junior Resident (Clinical) and Tutor/Demonstrator (Biochemistry) Posts. The eligible candidates can apply to the post through the prescribed format and walk in interview on 28 March 2017.

Junior Resident (Clinical) candidates must possess MBBS from the MCI recognized Institute. The Candidate must have compulsory rotatory internship and must produce internship completion certificate

Tutor/Demonstrator (Biochemistry) candidates must possess MBBS from the MCI recognized Institute or M.Sc. in Biochemistry. The Candidate must have compulsory rotatory internship and must produce internship completion certificate for MBBS Candidates

Eligible candidates can apply to the post through the prescribed format and walk in interview on 28 March 2017at 10:00am at Medical College of AIIMS, Jodhpur (Rajasthan).

Official Notification

Vacancy Summary

Notification details

Notification No. :Admn/Estt/01/JR/2017-AIIMS.JDH

Important Date:

Walk in interview - 28 March 2017 at 10:00

Age Limit Junior Resident (Clinical) and Tutor/Demonstrator (Biochemistry) Posts- 30 Years

Selection Procedure forJunior Resident (Clinical) and Tutor/Demonstrator (Biochemistry) PostsJob

The selection will be on the basis of the interview. The list of selected candidates will be uploaded on website. Candidates are advised to check the Institute website regularly for information

Application Fees for Junior Resident (Clinical) and Tutor/Demonstrator (Biochemistry) Posts

Gen & OBC : Rs.1000/-

SC/ST: NIL

Women Candidates: NIL

Official Website

http://www.aiimsjodhpur.edu.in

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Vacancies at AIIMS, Jodhpur for 48 Junior Resident and Tutor/Demonstrator (Biochemistry) Posts - Jagran Josh

How Many More Seasons Does Grey’s Anatomy Have Left In It? Ellen Pompeo Says… – E! Online

When Grey's Anatomy returns for its already-ordered 14th season this fall, it will not only air its 300th (!!) episode, but it'll finally tie classic sitcom The Adventures of Ozzie and Harriet for ABC's longest-running series ever. (And unlike that other show, Shonda Rhimes and Co. show no signs of slowing down!) In this day and age of Peak TV, for any series to even come close to a milestone like this is a damn near miracleand the cast knows it.

"It's been perfect to be able to have a job that you can go to," OG Grey's cast member Justin Chambers told E! News on the red carpet at the PaleyFest event honoring the series. "Just having a routine and working with people that you love and enjoying your character. To be able to say that you've been on a show this longit's a great gig to be able to say that."

Chandra Wilson, who's been there since day one alongside Chambers, couldn't help but agree. "I'll tell you, as an actor, the opportunity to be involved in something historic is amazing, so I love that," she gushed. "These characters and this show are cemented in history, so to know that little contribution is thereand it will always bethat's amazing. So it's a great honor."

Kevin McKidd, who joined the series five years into its run, couldn't be more thankful for getting the opportunity to be a part of Grey's Anatomy. "I pinch myself every single day that I'm part of it," he admitted. "It's unbelievable. I really feel honored and deeply grateful that I'm part of a thing that's actually making a piece of history. It's a really exciting thing and not to be taken lightly. These things don't happen often."

So, how much longer do Ellen Pompeo and her co-stars think they have left in them? Do they dare dream of giving Gunsmoke's record 20 seasons a run for their money in order to become TV's longest running live-action series ever?

"I don't know. I know that we want to try to," the leading lady herself admitted before stopping herself short. "Well, let's just see, you know? I don't like to take things for granted. You can't just assume the show can go on forever. It's up to the fans. And the fans will let us know how long they want the show to air."

In that case, she may want to settle in for the long haul, because if it's up to the fans, Grey's Anatomy isn't going anywhere anytime soon.

For more from Pompeo and her co-stars, be sure to check out the videos above.

Grey's Anatomy airs Thursdays at 8 p.m. on ABC.

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How Many More Seasons Does Grey's Anatomy Have Left In It? Ellen Pompeo Says... - E! Online

From Mind Control to Curing Brain Diseases, a Neuroscience Revolution Is Coming – Big Think

If the idea of physicalism is correct that all of our mental states can be described in purely physical terms then neuroscience is not only the study of our brains, but the study of our entire existence. Neuroengineering, defined as the application of engineering principles to neurological problems, then becomes how we engineer our relationship with existence itself.

Fifty years ago, nobody but computer programmers knew the personal computer was being developed, and the primary market for the device was thought to be scientists. Today, computers are a ubiquitous.

Digital technology has revolutionized nearly every facet of our lives. Today, neuroengineering is in a similar infancy. While most people would understand the basic idea ofusing engineering techniques to alter, improve, repair, and study neural systems, most people would lack for ideas on the application.

Dr. Ed Boyden is somebody who does not lack for those ideas.

ed-boyden-on-optogenetics-and-expansion-microscopy

As professor of Biological Engineering and Brain and Cognitive Sciences at the MIT Media Lab, Boyden has launched an award-winning series of classes at MIT which teach principles of neural engineering, starting with the basic principles of how to control and observe neural functions.While studying neuroscience at Stanford University as a Hertz Foundation Fellow, Boyden discovered that human memories are stored by a specific molecular mechanism, and that the content of a memory determines the mechanism used by the brain.

His work focuses on dramatically improving how the brain is imaged, opening a world of opportunities for people who wish to study the neural pathways that make our brains work. Dr. Boydens high resolution 3-D maps of the brain, unlike prior 2-D maps, allow researchers to pinpoint exactly what part of the brain they wish to focus on.

Resulting from improved mapping of the brain, one basic application of Boyden's work includes better treatment for brain injuries by altering the flow of electric signals through neurons. Some of Boyden's projects, however, seem to enter the world of science-fiction:

One concept that I think is emerging is what I like to call the brain coprocessor, a device that intimately interacts with the brain. It can upload information to the brain and download information from it. Imagine that you could have a technology that could replace lost memories or augment decision making or boost attention or cognition.

MOUNTAIN VIEW, CA - NOVEMBER 08: Actors Kumail Nanjiani and Martin Starr present Associate Professor, MIT Media Lab and McGovern Institute, Departments of Biological Engineering and Brain and Cognitive Sciences, Edward S. Boyden with the 2016 Breakthrough Prize in Life Sciences during the 2016 Breakthrough Prize Ceremony on November 8, 2015 in Mountain View, California. (Photo by Steve Jennings/Getty Images for Breakthrough Prize)

A cyborgian improvement to my memory and ability to focus? The ability to save my memories on a disk like a word file? Immortality for my experiences? Anything is possible. Already thousands of people have something similar to this technology helping them right now, but Dr. Boyden imagines something larger:

Although over a third of a million patients have had brain implants or neural implants that stimulate the nervous system, so far theyve operated in an open loop fashion. That is they drive activity in the brain but not in a fully responsive fashion. What we want to do is to have bidirectional communication to the brain. Can you read and write information continuously and supply maybe through coupling these interfaces to silicon computers exactly the information the brain needs. My hope is that over the next five to ten years were going to get deep insights thanks to our technologies into how brain circuits compute and that will drive the design of these interfaces so that we can deliver information to the brain and record information from the brain at a natural level speaking the natural language of the brain if you will in order to powerfully augment things like memory and thinking.

Such engineering and interfacing may even help us better understand what our consciousness is at all. In a remarkably interesting experiment Dr. Boyden explains how mice can have their brains stimulated to produce some prettybizarre behaviour.

A group at CalTech has activated certain clusters of cells deep, deep in the brains of mice. And if its the right cluster you can actually trigger a mouse to become aggressive or violent. Theyll attack whatevers next to them even if its like a rubber glove, right. So the idea that you can pinpoint the exact circuits in the brain that implement these complex, even ethically and philosophically relevant circuit to the brain I think is starting to open up a new convergence of how brain circuits work in the context of very interesting relevant behaviors. You can also study diseases. You can, for example, turn off overactive cells in a seizure and you can actually shut down seizures in animal models with epilepsy.

Is this the darkside of neuroengineering? After all, if all of our mental states, such as aggressiveness, are just physical, neurological, states, then giving us the ability to alter one would allow us to alter the other. This raises a myriad of ethical concerns for any widespread use of the technology. While the benefits of curing neural disease, improving cognitive function, and the like probably outweigh the negatives, we must take great care when making such alterations to our mental states.

Is this the wave of the future? Neuroengineering our way to better health, self-understanding, and ability? If it is, Dr. Boyden will have given us the map to it, if we are careful enough to avoid the ethical pitfalls he notices on the way there.

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From Mind Control to Curing Brain Diseases, a Neuroscience Revolution Is Coming - Big Think

7 psychological concepts that explain the Trump era of politics – Vox

These are strange, unsettling times. And for the past several months, Ive been asking psychologists variations on a basic question: What research can best help us reckon with uncomfortable social and political realities like the rise of Donald Trump, the widening partisan split, the divisiveness that comes with multiculturalism?

More than ever before, people of different ideological backgrounds seem to live in separate universes. One example: In the days after the inauguration, social scientists showed participants photos of Trumps inaugural crowd and Obamas. Those who had voted for Trump were more likely to say Trump had the larger turnout, despite obvious differences in the photos that demonstrated otherwise.

Psychology can help explain these tense times. Old theories, like motivated reasoning, are more clearly true than ever before. And new work has confirmed that humanity still contains its same base instincts of the prehistoric era.

Consider this a primer. Here are seven essential lessons on the hidden forces shaping our views and actions in the Trump era.

If you think I missed something that should be on this list, send me an email: brian@vox.com

One of the key psychological concepts for understanding politics is also one of the oldest.

Its called motivated cognition, or motivated reasoning. And theres no clearer example than in a paper published way back in the 1950s.

The Dartmouth versus Princeton football game of November 1951 was, by all accounts, brutal. One Princeton player broke his nose. One Dartmouth player broke his leg.

Princeton students blamed the Dartmouth team for instigating. The Dartmouth paper accused Princetons. In the contentious debates that ensued about "who started it," psychologists at the two schools united to answer this question: Why did each school have such a different understanding of what happened?

In the weeks after the Princeton-Dartmouth game, the psychologists Albert Hastorf and Hadley Cantril ran a very simple test. Their findings would become the classic example of a concept called motivated reasoning: Our tendency to come to conclusions were already favored to believe.

When they asked students at each of their universities to watch video highlights from the game, 90 percent of the Princeton students said it was Dartmouth that instigated the rough play. Princeton students were also twice as likely to call penalties on Dartmouth than their own team. The majority of Dartmouth students, on the other hand, said both sides were to blame for the rough play in the game, and called a similar number of penalties for both teams. Hastorf and Cantrils conclusion wasnt that one set of fans was lying. Its that being a fan fundamentally changes the way you perceive the game.

The lesson is simple: People are more likely to arrive at conclusions that they want to arrive at, the psychologist Ziva Kunda wrote in a seminal 1990 paper, making the case that motivated reasoning is real and pervasive.

And theres plenty of proof of it today. When Gallup polled Americans the week before and the week after the presidential election, Democrats and Republicans flipped their perceptions of the economy. But nothing had actually changed about the economy. What changed was which team was winning.

Motivated reasoning plays into why people from poor communities were willing to vote for Trump, a candidate whose party is keen to pare back the social safety net and has a proposed a health care bill that will lead to millions more becoming uninsured.

One crucial thing to know about motivated reasoning is that you often dont realize youre doing it. We automatically have an easier time remembering information that fits our world views. Were simply quicker to recognize information that confirms what we already know, which makes us blind to facts that discount it.

None of this psychology is to suggest that people who engage in motivated reasoning are stupid. No, they are just human. For example, a lot of evangelicals voted for Trump because of the simple fact he was the Republican presidential candidate, despite having reason to dismiss him after the Access Hollywood tape where he bragged about sexual assault leaked. Republican is the political team they play on. And that allowed them to find ways to justify their support.

Motivated reasoning can affect anyone, and liberals do it, too. Some are retweeting rogue federal Twitter accounts that have no verification that theyre indeed written by disgruntled federal staffers. At the Atlantic, Robinson Meyer asked Brooke Binkowski, the head of fact-checking website Snopes.com, if fake news targeted toward liberals is on the rise. Of course yes! she said. (See some examples here.)

Lets remember that.

If a group of people have the same, solid grounding in the same facts about politics, then everyone should come to the same conclusions, right? Wrong.

Study after study has shown that this assumption is not supported by the data, says Dietram Scheufele, who studies science communication at the University of Wisconsin.

In fact, studies show the exact opposite: The more informed people are about politics, the more likely they are to be stubborn about political issues.

This concept is related to motivated reasoning, but its important enough to warrant its own consideration. It shows how motivated reasoning becomes especially stubborn and ugly when it comes to politics.

People are using their reason to be socially competent actors, says Dan Kahan, a psychologist at Yale, and one of the leading experts on this phenomenon. Put another way: We have a lot of pressure to live up to our groups expectations. And the smarter we are, the more we put our brain power to use for that end.

In his studies, Kahan will often give participants different kinds of math problems.

When the problem is about nonpolitical issues like figuring out the whether a drug is effective people tend to use their math skills to solve it. But when theyre evaluating something political lets say, the effectiveness of gun control measures the trend is that the better participants are at math, the more partisan they are in their responses.

Partisans with weak math skills were 25 percentage points likelier to get the answer right when it fit their ideology, Ezra Klein explained in a profile of Kahans work. Partisans with strong math skills were 45 percentage points likelier to get the answer right when it fit their ideology. The smarter the person is, the dumber politics can make them.

And its not just for math problems: Kahan finds that Republicans who have higher levels of science knowledge are more stubborn when it comes to questions on climate change. The pattern is consistent: The more information we have, the more we bend it to serve our political aims. Thats why the current debate over fake news is a bit misguided: Its not the case that if only people had perfectly true information, everyone would suddenly agree.

So think of that when you hear politicians or pundits talk shop: They know a lot about politics, but theyre bending what they know to fall in line with their political goals. And they probably dont realize they are doing this and can feel confident in their partisan conclusions because they feel well informed.

Theres a reason why we engage in motivated reasoning, a reason why facts often dont matter: evolution.

Critical thinking and reasoning skills evolved because they made it easier to cooperate in groups, Elizabeth Kolbert explains in a recent New Yorker piece. Weve since adapted these skills to make breakthroughs in topics like science and math. But when pressed, we default to using our powers of mind to get along with our groups.

Psychologists theorize thats because our partisan identities get mixed up with our personal identities. Which would mean that an attack on our strongly held beliefs is an attack on the self.

The brains primary responsibility is to take care of the body, to protect the body, Jonas Kaplan, a psychologist at the University of Southern California, says. The psychological self is the brains extension of that. When our self feels attacked, our [brain is] going to bring to bear the same defenses that it has for protecting the body.

Its like we have an immune system for uncomfortable thoughts.

Recently, Kaplan has found more evidence that we tend to take political attacks personally. In a study recently published in Scientific Reports, he and collaborators took 40 self-avowed liberals who reported having deep convictions, put them inside in a functional MRI scanner, and started challenging their beliefs. Then they watched which parts of the participants brains lit up.

Their conclusion: When the participants were challenged on strongly held beliefs, there was more activation in the parts of the brain that are thought to correspond with self-identity and negative emotions.

Theres a dynamic playing out in the current health care debate, and in health care debates of ages past. Liberals make their arguments for expanding coverage in terms of equality and fairness (i.e., everyone should have a right to health care), while conservatives make their case grounded in self-determination (i.e., the government shouldnt tell me how to live) and fiscal security (i.e., paying for health care will bankrupt us all).

According to a psychological theory called moral foundations, its no surprise that these arguments fail spectacularly at changing minds.

Moral foundations is the idea that people have stable, gut-level morals that influence their worldview. The liberal moral foundations include equality, fairness, and protection of the vulnerable. Conservative moral foundations favor in-group loyalty, moral purity, and respect for authority.

These moral foundations are believed to be somewhat consistent over our lifetimes, and they may have a biological basis as well. (Theres some fascinating experimental work that shows that conservatives are more excited as measured by perspiration by negative or alarming images.)

Moral foundations explain why messages highlighting equality and fairness resonate with liberals and why more patriotic messages like make America great again get some conservative hearts pumping.

The thing is, we often dont realize that people have moral foundations different than our own.

When we engage in political debates, we all tend to overrate the power of arguments we find personally convincing and wrongly think the other side will be swayed.

On gun control, for instance, liberals are persuaded by stats like, "No other developed country in the world has nearly the same rate of gun violence as does America." And they think other people will find this compelling, too.

Conservatives, meanwhile, often go to this formulation: "The only way to stop a bad guy with a gun is a good guy with a gun."

What both sides fail to understand is that they're arguing a point that their opponents may be inherently deaf to.

In a study, psychologists Robb Willer and Matthew Feinberg had around 200 conservative and liberal study participants write essays to sway political opponents on the acceptance of gay marriage or to make English the official language of the United States.

Almost all the participants made the same mistake.

Only 9 percent of the liberals in the study made arguments that reflected conservative moral principles. Only 8 percent of the conservative made arguments that had a chance of swaying a liberal.

No wonder why its so hard to change another persons mind.

Nour Kteily, a psychologist at Northwestern University, conducts research on one of the darkest, most ancient, and most disturbing mental programs encoded into our minds: dehumanization, the ability to see fellow men and women as less than human.

Psychologists are no strangers to this subject. But the prevailing wisdom has been that most people are not willing to admit to having prejudice against others.

Wrong.

In Kteilys studies, participants typically groups of mostly white Americans are shown this (scientifically inaccurate) image of a human ancestor slowly learning how to stand on two legs and become fully human. And then they are told to rate members of different groups such as Muslims, Americans, and Swedes on how evolved they are on a scale of 0 to 100.

Many people in these studies give members of other groups a perfect score, 100, fully human. But many others give others scores putting them closer to animals.

With the Ascent of Man tool, Kteily and collaborators Emile Bruneau, Adam Waytz, and Sarah Cotterill found that, on average, Americans rate other Americans as being highly evolved, with an average score in the 90s. But disturbingly, many also rated Muslims, Mexican immigrants, and Arabs as less evolved.

We typically see scores that average 75, 76, for Muslims, Kteily says. And about a quarter of study participants will rate Muslims on a score of 60 or below.

People who dehumanize are more likely to blame Muslims as a whole for the actions of a few perpetrators. They are more likely to support policies restricting the immigration of Arabs to the United States. People who dehumanize low-status or marginalized groups also score higher on a measure called social dominance orientation, meaning that they favor inequality among groups in society, with some groups dominating others.

And, in a study, blatant dehumanization of Muslims and Mexican immigrants was strongly correlated with Trump support and the correlation was stronger for Trump than any of the other Republican candidates.

In the lead-up to the 2016 election, fear seemed to be everywhere.

After the terrorist attacks in Paris and Brussels, Donald Trump and conservative allies redoubled their promises to make borders more secure and ban whole religious groups from the country. Trumps rhetoric often underscored an us-versus-them mentality illegal immigrants from Mexico were raping our people; countries like China were destroying us on trade.

A lot of new psychological evidence suggests that stoking peoples racial and demographic fears helped Donald Trump win votes.

Negative, scary information is almost always more sticky and memorable than positive information

One of those studies explored the question of what white people feel when they are reminded that minorities will eventually be the majority. And it found that they begin to feel less warm toward members of other races. A more recent experiment showed that reminding white people of this trend increased support for Trump.

What this doesnt mean is that all white people harbor extreme racial animus. It means fear is an all-too-easy button for politicians to press. We fear unthinkingly. It directs our actions. And it nudges us to believe the person who says he will vanquish our fears.

People who think of themselves as not prejudiced (and liberal) demonstrate these threat effects, says Jennifer Richeson, a leading researcher on racial bias.

Theres also this fact to contend with: Negative, scary information is almost always more sticky and memorable than positive information. Negative events capture attention and information processing more readily, elicit strong emotions more easily, and are more memorable, psychologists Daniel Fessler, Anne Pisor, and Colin Holbrook, wrote in a recent study.

They showed participants 14 plausible but false statements, like Kale contains thallium, a toxic heavy metal, that the plant absorbs from soil. Some of the statements, like the one above, implied a warning (dont eat Kale!), others were positive, like Eating carrots results in significantly improved vision.

Participants often found the threatening statements more credible than the non-threatening one, and this was especially true among more conservative participants (and especially true for social conservatives, as compared to fiscal conservative). This is not because conservatives are more gullible. Its because they tend to be more vigilant.

Savvy politicians understand this, and craft messages that stoke that innate vigilance (whether concern is warranted or not). Its hard to blame people for being afraid of threats. Its just in our nature. But you can blame politicians who prey on it.

Other researchers have arrived at similar findings.

Last year, Willer and Feinberg published a paper that found that racial attitudes predicted support for the conservative Tea Party movement. In one study, they showed participants an artificially darkened portrait of President Barack Obama to maximally remind participants hes African American. White participants shown the darkened photo were more likely to report they supported the Tea Party relative to a control condition, the study reported.

Similarly, they found that reminding study participants about a coming minority-majority America made them more likely to support the Tea Party platform.

In the 1960s, Stanford psychologist Albert Bandura showed how easy it is to teach kids to act violently by showing them an adult acting violently.

In this famous experiment, Bandura showed young children between 3 and 6 years old a video of an adult wailing on an inflatable bobo doll (see in the video below). Other children in the study did not see an adult behaving aggressively to the doll.

And sure enough: The kids who saw the aggressive behavior were more aggressive themselves when playing with the doll later on.

Its a simple experiment with a simple conclusion: As humans, even at an early age we learn whats socially acceptable by watching other people.

Lately, weve been witnessing an unsettling number of brazen hate crimes and vandalism against Muslim and Jewish institutions. Its hard to directly link these crimes to the charged political climate. But like Banduras experiment, theres evidence that social norms against prejudice change when people in power start talking and behaving badly.

Some psychologists think Trumps rhetoric and the rise of the alt-right movement that supported him are similarly encouraging people with prejudicial views to act upon them.

I dont think Trump created new prejudices in people not that quickly and not that broadly what he did do is change peoples perceptions about what is okay and what is not okay, University of Kansas psychologist Chris Crandall says.

Recently Crandall and his student Mark White asked 400 Trump and Clinton supporters to rate how normal it is to disparage members people of various marginalized groups like the obese, Muslims, Mexican immigrants, and the disabled both before the election and in the days after.

Both Clinton and Trump supporters were more likely to report it was acceptable to discriminate against these groups after the election. For Trump to say the disparaging things he said during the campaign, and then be rewarded for them, sent a powerful sign.

It took away the suppression from the very highly prejudiced people, Crandall said. And those are people acting.

These results are preliminary (i.e., not yet published in a journal), but theyre reflective of the established literature: Exposure to misbehavior simply makes it more acceptable.

Heres one example. In 2004, sociologists Thomas Ford and Mark Ferguson found that exposure to a racist or sexist joke increased tolerance of further discrimination in people who held prejudicial views. Hearing the off-color joke, they write, Expands the bounds of appropriate conduct, creating a norm of tolerance of discrimination.

Theres still many more questions psychologists want to answer about this political age. Its not enough to define problems in prejudice and reasoning, psychologists are also seeking to solve them. But many answers are still out of reach.

Psychology has been called the hardest science because the human mind comes with so many messy inconsistencies that even the top researchers can get tangled up in. It can take decades to establish a psychological theory, and in just months, new evidence can tear it down. Despite its flaws, psychology is still the best scientific tool we have to understand how human behavior shapes the world.

There are a lot more concepts in psychology that can help us understand whats going on in the world of politics. Here are a few more worth learning about.

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7 psychological concepts that explain the Trump era of politics - Vox

The climate, not just genetics, shaped your nose – E&E News

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Kavya Balaraman, E&E News reporter

New research from researchers at Pennsylvania State University indicates that the human nose has, over millennia, tailored itself to best suit the climate in which it finds itself. Photos courtesy of Pixabay.

The planet's climate has shaped continents, coastlines, land-use patterns and the human nose.

New research indicates that the human nose has, over millennia, tailored itself to best suit the climate it finds itself in. In a nutshell, warmer and more humid environments are populated by wide-nosed people, while narrower noses are more preferable in colder, drier regions.

"We looked at different parts of the nose, and nostril width sticks out as a measurement that's significantly different in different populations," said Arslan Zaidi, a graduate student with Pennsylvania State University's anthropology department and author of the study. "It's more different than can be explained by genetic drift a random evolutionary force."

While scientists have noticed the discrepancy in nose widths and geographic regions before, this is the first piece of concrete evidence that the different shapes can be attributed to climatic conditions. Zaidi and his team studied the shapes and sizes of noses from different communities and ancestries West African, South Asian, East Asian and Northern European and found that there was a strong correlation between the width of the nose in different regions and local humidity levels and temperature. While a multitude of factors go into shaping the nose, they concluded, climate is definitely one of them.

From an evolutionary point of view, narrower noses make more sense in colder regions of the world, said Zaidi.

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"One of the most important functions of the nose is to warm and humidify the air we breathe before it gets into our lungs that's important because it helps catch pathogens and particles entering our respiratory track," he explained, adding, "We know from functional studies of fluid dynamics inside the nose that narrower noses tend to introduce more turbulence into the air. That allows the air to better mix with the lining inside the nose."

According to Mark Shriver, a professor of anthropology at Penn State, people with narrow noses probably had better chances of surviving and having more offspring in colder climates than their wider-nosed counterparts. This would mean that gradually, regions far away from the equator would be populated more by people with narrower noses.

Apart from being an issue of anthropological interest, the findings could have medical implications, as well, said Zaidi.

"In general, adaptation is important to study because our evolutionary history is directly tied to disease risk. A classic example is skin pigmentation," he said. "People who are lighter, who move near the equator, have higher UV exposure and a higher risk of skin cancer. Away from the equator, the flip side is true darker people are at a higher risk of Vitamin D deficiency."

A better understanding of skin pigmentation can help address these issues, he added.

"I'm Pakistani and I live in the U.S., so my skin blocks out more sun than it should. Understanding this helps us to think about preventing these risks for instance, I could take vitamin supplements," he explained, adding that similarly, understanding the links between climatic conditions and nose shapes could help the medical community address respiratory diseases, he added.

Zaidi stressed, however, that this is still a preliminary result.

"We are offering a hint," he said. "We've studied the genetics of nose shape, but I think a clearer picture of the evolutionary history of the nose will appear when we look at specific genes underlying those and identify them. At the DNA level, the signal of evolutionary history is much cleaner."

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The climate, not just genetics, shaped your nose - E&E News

McCain and Montenegro: The Anatomy of a Conspiracy Theory by … – Antiwar.com

Just in case you thought the conspiracy theory that Russia secretly controls the US government is exclusively an affliction affecting the Democratic party, Sen. John McCains recent performance on the floor of the US Senate should disabuse you of this optimistic notion. Responding to Sen. Rand Pauls blocking of a vote in favor of the accession of Montenegro to NATO, the failed former GOP presidential candidate let it all hang out:

I note the senator from Kentucky leaving the floor without justification or any rationale for the action he has just taken. That is really remarkable, that a senator blocking a treaty that is supported by the overwhelming number, perhaps 98 at least of his colleagues would come to the floor and object and walk away. The only conclusion you can draw when he walks away is he has no justification for his objection to having a small nation be part of NATO that is under assault from the Russians. So I repeat again, the senator from Kentucky is now working for Vladimir Putin.

Whats remarkable is that this kind of lunacy is tolerated in the US Senate: I recall that Sen. Elizabeth Warren was rebuked and silenced by Senate majority leader Mitch McConnell because she read a letter from Coretta Scott King that called into question the motives of Jeff Sessions, then a Senator and a candidate for the office of Attorney General. Surely McCains outburst was an even more egregious violation of the rules than Warrens, and yet McCain was allowed to proceed uninterrupted. Perhaps this is an example of warmongers privilege.

In a later interview, Sen. Paul sought to explain McCains behavior as an indication of the Senator from Arizonas advanced age: perhaps, he suggested, McCain is past his prime, and, by the way, this is a good argument for term limits. Well, yes, but in the current political atmosphere where Vladimir Putin has been elevated to the status of a virtually omnipotent force who has the power to change election results and infiltrate the highest reaches of Western governments its no crazier than anything else were hearing out of Washington these days.

Be that as it may, ordinary Americans may have a few questions about this bizarre incident, starting with: What the heck is Montenegro?

A tiny republic in the middle of the Balkans, Montenegro has a population equal to that of Albuquerque, New Mexico, and a military force of around 2,000 soldiers and sailors. Up until the break up of Yugoslavia, it was never a unified independent country (except for a few years early in the twentieth century). Today, it is even less unified, beset as it is with rival factions that routinely battle it out in the streets. Its former President (and, alternately, Prime Minister) Milo Djukanovic, is a former top Communist official who came to power in 1997 in an election marred by allegations of fraud and violent protests, and is known as Mr. Ten Percent on account of his reputation for corruption. Although retired (this is, I believe, his third retirement) he is still the real nexus of power in the country.

Formerly a bastion of Serbian nationalism, Montenegro has undergone demographic changes since the end of the Yugoslav era, with a large incursion of Albanians who have initiated a campaign to create a Greater Albania by merging the southern portion of the country with Albania proper. Aside from that, however, there is the question of whether Montenegro will join NATO and the European Union, a project dear to the heart of Djukanovic, and opposed by the former Serbian majority which still remembers how the country was bombed under NATOs rubric during the Kosovo war.

The recent elections, billed as a referendum on NATO membership, yielded ambiguous results for Djukanovics party: the hope was that Djukanovics Democratic Party of Socialists (DPS), the successor to the old Communist Party, would win an outright majority, thus enabling the pro-NATO forces to push NATO membership through parliament without having to resort to a referendum. The DPS ended up winning 41 percent of the vote, not enough to form a government, although an alliance with smaller parties not all of them pro-NATO gave Djukanovic a parliamentary majority. The opposition parties are now pushing for a popular vote on entering NATO, and recent polls indicate that voters are split almost exactly down the middle on the issue.

That doesnt deter Djukanovic, who, with the help of the Western media, has managed to replicate the anti-Russian hysteria we are seeing infect our own politics. According to Djukanovic, a Russian plot to attack the parliament, kill members of the ruling party, and take over the country was narrowly averted when a number of plotters were arrested. The New York Times describes these sinister plotters as follows:

Mr. Djukanovic and his officials initially provided no evidence to support their allegation of a foiled coup attempt on Oct. 16, the day of national elections. They said only that 20 Serbs some of whom turned out to be elderly and in ill health had been detained just hours before they were to launch the alleged putsch. Nonetheless, Mr. Djukanovic insisted it is more than obvious that unnamed Russian structures were working with pro-Moscow politicians to derail the countrys efforts to join NATO.

After months of searching, the alleged weapons cache that was to be used in the coup attempt has yet to turn up. But, hey, who needs weapons when youre part of the vast Putinite Conspiracy? Oh, those Russians stealing elections from Michigan to Montenegro! Is there anything they cant do? The alleged leader of the plot has been granted a plea deal, and is now spinning a tale of intrigue so murky that light cannot penetrate its depths. One version has it that Russian special forces disguised as a Cossack folk band arrived on the scene to recruit those plotting to off Djukanovic. Those are some very special forces indeed. Oddly, the alleged plotters have all been released, including the supposed ringleader. Meanwhile, leaders of the anti-NATO opposition are being arrested for ties to the plot.

This what Sen. McCain was talking about when he claimed that Montenegro is under assault from the Russians. Its the Montenegrin version of the same line of baloney hes been pushing here in the US: that the Russians stole the 2016 presidential election, and are subverting American democracy.

Sen. Paul was right to block approval of Montenegros accession to NATO: that country is the perfect backdrop for an international incident that would drag us into a conflict with Russia. In accusing Paul of working for Vladimir Putin, McCain is limning the tactics of Djukanovic, who is busy framing up and arresting his political opponents on similarly phony charges.

The alleged Russian agent Mike Flynn, forced to resign as National Security Advisor because of his nonexistent ties to Moscow, reportedly recommended that the Trump administration approve Montenegros bid to join NATO. I guess he didnt get his directive from Putin in a timely manner. On the other hand, the Montenegrin opposition is petitioning Trump advisor Steve Bannon to urge the President to veto it.

Montenegros accession to NATO would plant yet another tripwire that could easily lead directly to a collision with Russia. At the very least it would cause substantial internal turmoil in the country, perhaps ending in an all-out civil war such as happened in Ukraine.

President Trump was right when he said during the campaign that NATO is obsolete. It is also dangerous in that it pledges us to go to war in defense of member nations. With Turkey, a NATO member, moving rapidly into Syria, and now face-to-face with Russian and Syrian soldiers, and with British troops now entering Estonia, where a make-believe Russian threat is supposedly being thwarted, our membership in NATO could very well drag us into a conflict on two fronts.

How is this putting America first?

NOTES IN THE MARGIN

You can check out my Twitter feed by going here. But please note that my tweets are sometimes deliberately provocative, often made in jest, and largely consist of me thinking out loud.

Ive written a couple of books, which you might want to peruse. Here is the link for buying the second edition of my 1993 book, Reclaiming the American Right: The Lost Legacy of the Conservative Movement, with an Introduction by Prof. George W. Carey, a Foreword by Patrick J. Buchanan, and critical essays by Scott Richert and David Gordon (ISI Books, 2008).

You can buy An Enemy of the State: The Life of Murray N. Rothbard (Prometheus Books, 2000), my biography of the great libertarian thinker, here.

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McCain and Montenegro: The Anatomy of a Conspiracy Theory by ... - Antiwar.com

PaleyFest 2017: Grey’s Anatomy Cast Talks Shonda Rhimes – Vulture – Vulture

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PaleyFest 2017: Grey's Anatomy Cast Talks Shonda Rhimes - Vulture - Vulture

NASCAR Phoenix recap: The anatomy of Ryan Newman’s upset win – SB Nation

NASCARs version of March Madness didnt involve a buzzer-beater and a small school few recognized toppling one of college basketballs blueblood programs. Nevertheless what transpired Sunday at Phoenix International Raceway certainly qualifies as an upset, a reminder of what can transpire when circumstances converge resulting in an unforeseen outcome.

If prior to the Camping World 500 you were to draw up a list of potential winners, Ryan Newmans name certainly would not have been among the first dozen or so chosen. Thats what happens when you havent won in 127 races, while your team, Richard Childress Racing, has gone winless in the past 112 races with neither showing much indication of snapping their streaks of futility.

For much of Sunday, the fourth Monster Energy Cup Series played out as expected. Pole-sitter Joey Logano dominated early in winning the first stage, with promising second-year driver Chase Elliott asserting himself in the second stage. Then, Kyle Busch seized control in the decisive final stage.

At no point before the final two laps did it appear Newmans name would be etched on the winners trophy.

But the race that had seemingly been so clear-cut took an entirely different focus when Loganos overheated right-front tire exploded, sending him crashing into the outside Turn 1 wall with four laps remaining. This placed the crew chiefs for Busch and others running up front in a difficult position where they had to choose between pitting for fresh tires and foregoing track position, or staying out on older tires.

Newman, who was seventh, thought it best to pit and take two tires. Crew chief Luke Lambert thought otherwise. He wanted to go for the win, figuring that with so few laps left their best chance stood if they stayed out, thereby placing Newman in a position where he would need to play defense.

It was the only opportunity we had to win the race, Lambert said. I felt like doing it was going to yield a better result than the other option. Ultimately that was the decision. He said he could make the car wide. He did.

It was now Newmans race to win or lose. The key would be the restart. If he could get away cleanly and not have those behind on fresh tires get a run entering Turn 1, he stood a chance.

Newmans mind flashed back to late restart in last falls playoff race at Phoenix, when leader Matt Kenseth found himself in a similar position. On that day, Alex Bowman had been able to get to the inside of Kenseth, who came down and clipped Bowman sending him spinning. Logano would go on to win, while Kenseth not only lost the race but was also eliminated from the playoffs.

You're on old tires, it's easy to screw up, Newman said. You got to get your tires cleaned off right. You got to get a good launch. You got to run through the gearbox right. Then you got to hold everybody off.

The stakes werent as high Sunday as they were in November when a berth in the championship finale was on the line, but for a driver and team in the midst of a three-year-plus dry spell, what was before them carried considerable importance.

Kyle Larson had been second before the caution and after pitting he would be fourth, the highest-placed among drivers on fresh tires, and in the preferred outside groove. He would likely be Newmans biggest threat provided he didnt get bogged down in traffic.

That didnt occur.

When the green flag waved Newman did his part and edged ahead, but as anticipated Larson got a terrific restart and was closing. However, instead of exercising patience, Larson attempted to swing low and to the inside of Newman. Unbeknownst to Larson, Ricky Stenhouse Jr. was there and Larson cut across his nose just as Kenseth had done to Bowman last fall.

Hindsight is always 20/20, but I should have went a lane up in (Turns) 1 and 2, Larson said. I should have known to just stay close to Newman. That's what I wish I would have done.

To his credit, Larson didnt crash. The bobble, though, allowed Newman to build enough of a gap that there wasnt enough time to chase him down and make a pass.

For the first time since July 28, 2013, Newman was on his way to victory lane. And for the first time since Nov. 3, 2013, a RCR driver had picked up a Cup Series checkered flag.

Going a long time without winning, you have confidence in your mind that you can do it, Newman said. You just got to stay humble. This sport, you walk away from it, there's one guy that wins, 39 losers. You have to be humble walking into it that you're probably not going to win that day. Odds are against you.

On the surface it may appear as if Newman stole a race he had no business winning. That couldnt be farther from the truth.

It took a combination of sage strategy by Lambert and Newmans veteran savviness to make it happen. The other six teams ahead of Newman couldve employed the same strategy as Lambert and not pitted under the final caution. Yet, it was Lambert who made the correct call. And on worn tires, it wouldve really been easy for Newman to stumble on the restart.

Sunday may have been an upset, but dont think for a second that it wasnt earned.

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NASCAR Phoenix recap: The anatomy of Ryan Newman's upset win - SB Nation