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Neuroscience firms up companies’ efficiency – Business Day (registration)

About 30% of what is eaten is used to fuel the brain, so healthy eating is good. "People make food choices because they are on a diet or training for sport, but no one not even someone who is paid to use his or her brain wakes up and thinks, What should I eat so I can make better decisions or think flexibly to solve complex problems?"

The first rule is to eat regularly. Meals should not be skipped because brains cannot store nutrients and will slip into low-power mode. Recommended foods are salmon, avocado, eggs, nuts, olives and coconut oil.

Another hot topic is technologys effect on the brain. Having calm time before bed is common sense, but the scientific reason makes it more compelling. "The blue light emitted from smartphones, tablets or laptops sends a message to your pineal gland that it is still daytime and it should not release the hormone melatonin that helps you fall asleep. So stop looking at those screens an hour before you want to fall asleep," Swart says.

Another topic she will deal with is "imposter syndrome", in which high-powered and successful people feel like frauds. When Swart began covering this in her talks, people would come up afterwards and confess that was how they felt.

"Successful people such as hedge-fund billionaires say they feel like they should not be in that position and they are afraid one day they will be found out as people realise they should not have risen this far," she says. "It has nothing to do with skills. They are skilled and no one else is thinking they cannot do their job. It is the creeping thought at the back of their mind that one day they will be found out," Swart says. The answer is to learn positive ways of overwriting those pathways in the brain and increasing peoples resilience and confidence by focusing on past successes.

That relates to her favourite topic of neuroplasticity the brains ability to rewire and build new pathways to relearn something or acquire new skills. Many people claim they are too old to learn new tricks or change their ways, but science has shown that is not true.

Neuroscience can also help people make better decisions before taking financial risks. Stress hormones and testosterone change when attempting something risky. Boosting testosterone brings extra confidence. A combination of certain foods and weight-bearing exercise can also achieve that. "Do some weights and eat cabbage afterwards, because there is a chemical compound in cabbage that has an effect on your testosterone levels," Swart advises.

Stress people feel at work affects their mood, decision-making abilities and capacity to bounce back from adversity.

Because leaders skills are affected by their mental state, Swart believes changes must be driven by companies, not individuals. It is happening slowly. Office gyms are being supplemented by yoga or meditation rooms, canteens are serving brain food and water coolers are being installed so people can remain hydrated.

Swart has been visiting SA for almost 20 years, first as a medical student working with HIV-positive babies, then as a doctor and now as a neuroscience coach.

The companies she consults for are mostly in the financial services and legal sectors.

She finds South Africans need this advice more than most, because the "boys dont cry" attitude is so engrained.

"The culture of organisations has to change. Having a culture of people doing exercise and eating healthily and being able to talk about stress is really important and it has to come from the leadership," she says.

Neuroscience for Leadership will run at the Turbine Hall, Newtown, Johannesburg, on May 25.

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Neuroscience firms up companies' efficiency - Business Day (registration)

IMMUNOLOGY 2017 May 12 16, 2017 | Washington, D.C.

Development of Inexpensive Multiplex Immunoassays: Assessment of Food Allergens in Plasma

1:45 AM 2:30 PM EXHIBITOR WORKSHOP ROOM 2 SCIENION US, Inc.

Presenter:

Attack by foreign substances, such as allergens, triggers a cascade of events, in which IgE is a first responder. An allergic reaction to certain foods, e.g., shellfish or peanuts, can elicit a response within minutes of ingestion. There are also more subtle responses, such as IgG, which remains in the bloodstream for an extended period, and is monitored to assess this delayed response. Th2 cytokines are involved in the humoral response, leading to the production ofIgE antibodies. Other cytokines, such as IL-25, are also involved in the induction of Th2 responses. In this study, a microplate-based microarray of allergenic proteins from food sources was constructed together with antibodies to measure inflammatory cytokines. Plasma from patients with known food allergy was assessed for specific IgG subclasses, specific IgE, and Th2 cytokine levels. Quantitative multiplex immunoassays were performed, and resulted in bright and colorful spots. The plates were analyzed using a novel colorimetric microplate imaging reader (sciREADER CL2, Scienion).

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IMMUNOLOGY 2017 May 12 16, 2017 | Washington, D.C.

How Decline in Remicade Is Affecting Merck’s Immunology Revenues – Market Realist

What's Driving Merck's Valuation in 2017? PART 6 OF 9

Remicade, one of the top-selling drugs for the treatment of inflammatory disorders, is losing its market share after the loss of exclusivity in European markets in 2015. Merck (MRK) has reported a constant decline in Remicade revenues. Apart from Merck, Johnson and Johnson (JNJ) also has marketing rights of Remicadein certain countries outside Europe.

Remicade revenues fell ~29% to $1.3 billion in 2016 as compared to $1.8 billion for 2015. The fall was mainly due to the entry of generic competitors and biosimilars following the loss of exclusivity in European markets. Merck expects Remicade revenues to fall further in the future as new patients prefer biosimilars over Remicade.

Simponi is another drug in the immunology franchise. Simponi revenues rose 11% to $766 million in 2016 as compared to $690 million for 2015.

Zetia and Vytorin are blockbuster drugs from Mercks cardiovascular portfolio. Both of these drugs are used to lower the LDL cholesterol levels in the blood. The combined revenues for these drugs fell to $3.70 billion in 2016. Global sales were affected due to the loss of exclusivity of Vytorin in the US, while Zetia sales improved 1% for 2016 as compared to 2015.

The competitors for Zetia include Niaspan from AbbVie (ABBV) and Lipitor from Pfizer (PFE). To divest the risk, investors can consider ETFs like the Health Care Select Sector SPDR ETF (XLV), which holds 6.3% of its total assets in Merck.

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How Decline in Remicade Is Affecting Merck's Immunology Revenues - Market Realist

Anatomy Of A Decision, Part 5: The West Wing – Benzinga

GLG has produced a new series of videos focused on decision making in the business world.

As part of the series, GLG, the world's leading membership network for professional learning, has interviewed a number of business leaders to ask about what considerations go into making important decisions.

In this installment, GLG spoke with Jake Sullivan, a former advisor to former President Barack Obama, about critical decisions involved in the policy-making process in Washington.

Sullivan played a critical role in the Obama administrations controversial nuclear deal with Iran. He said no matter how confident he was in the work the administration had put into the deal, the moment when the president asked his opinion on whether or not they should accept the final terms was very difficult.

Being able to make that decision to recommend to the president that we go ahead and do this deal required stepping back from the anxiety, the emotion, the nerve-wracking idea that maybe we were going to screw this thing up and actually systematically running a cost benefit analysis, he said. By taking emotion out of the equation, he saw that the benefits of the deal far outweighed the cost.

The hard thing about a decision like that is that somebody can always come along, and many did, and say you could have gotten a better deal. And you have to be prepared to stand there, look people in the eye and say, I believe this is a good deal and its as good as we are going to be able to do right now.

Sullivan also addressed the unpredictability of the Trump administration and whether or not unpredictability can be an advantage when it comes to foreign policy. He said unpredictability can be an advantage, but it should be used rarely and strategically.

Richard Nixon actually talked about the crazy man theory of foreign policy, and there are moments for that, but it cant be every moment. And I think that is what makes the current situation quite challenging.

Related Links:

Anatomy Of A Decision, Part 1: The C-Suite

Anatomy Of A Decision, Part 2: The Newsroom

Anatomy Of A Decision, Part 3: Minorities In The Boardroom

Anatomy of a Decision, Part 4: The Admissions Office

_______ Image Credit: "United States President Barack Obama talks with Secretary of State Hillary Rodham Clinton about his decision to send her to the Middle East while attending the US-ASEAN Summit in Phnom Penh, Cambodia on 20 November 2012. From left are: Ben Rhodes, Deputy National Security Advisor for Strategic Communications; Jake Sullivan, Deputy Chief of Staff to the Secretary of State; and National Security Advisor Tom Donilon." By Pete Souza - White House Flickr account P112012PS-0453, Public Domain, https://commons.wikimedia.org/w/index.php?curid=22813121">via Wikimedia Commons

Posted-In: Anatomy of a Decision GLG Jake SullivanPolitics Interview General Best of Benzinga

2017 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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Anatomy Of A Decision, Part 5: The West Wing - Benzinga

Spoiler Room: Scoop on Supergirl, Grey’s Anatomy, Blindspot, and more – EW.com

Welcome to the Spoiler Room, a safe place for spoiler addicts to come on a weekly basis to learn whats coming next on their favorite shows and, hopefully, get a few of their own questions answered. If you want scoop on a specific show, send your questions to spoilerroom@ew.com.

Hi, whats next for Mon-El and Kara from Supergirl? Maria Well, Kara and Mon-El may have reconciled, but there are certainly challenges moving forward considering the Daxamites are slated to become the new big bads. Isnt that how things work that just when you get things settled, some wrench has to fall into the gears? Melissa Benoist says. The Daxamites pose some problems. Rhea is not necessarily a sweet prospect for a mother-in-law, but its really fun to see the way these characters interact.

Whats next for Meredith and Riggs on Greys Anatomy? Sarah Yes, Meredith has agreed to a date with Riggs, but is she actually ready to move on after Derek? Whether youre ready or not, you have to make the leap; I dont know if shes ready, Ellen Pompeo admits, cautioning that Meredith faces a big choice when it comes to her potential romance with Riggs in the upcoming episode she directed. Dont get too excited, she says of the Mer-Riggs romance. Ruh-roh! For her part, Kelly McCreary thinks Maggie will eventually handle the truth about her sister and Riggs in an unexpected way. Maggie maybe has to learn that people dont always tell you the truth, she says. Lots of people keep secrets, and thats just how it goes, and then shell suffer a lot less in life.

I always need Blindspot scoop! Jessica A familiar face will be back in the April 5 episode but its not a welcome return. Devilishly charming Assistant U.S. Attorney Matthew Weitz, played by Blindspot favorite Aaron Abrams, returns on a mission to bring down the team, EP Martin Gero tells me. Heres an exclusive first look at his return:

I need some Arrow finale scoop! Drew Ask and you shall receive: As the season heads toward the ultimate showdown between Oliver and Chase, were going to be seeing a very different season finale this year. Were not going to destroy the city, EP Marc Guggenheim teases. Were not even going to threaten the city. In fact, I can also tell you the finale doesnt even take place in the city. Finally, the citizens of Star City can breathe easily in May. Wherever the finale takes place, Guggenheim adds, You can expect a good number of returning characters, characters you havent seen in a while, back in the episode.

Is there any hope for reconciliation between Marcel and the Mikaelsons on The Originals? Mark We all know Klaus Mikaelson isnt prone to forgiveness, but considering Marcel is someone he once considered a son, its not off the table. But lets not forget that Marcel is still strong enough to kill an Original, a threat that wont sit well with anyone. Over the course of the season, the Mikaelsons are going to have to deal with the fact that theres this person its not a White Oak stake that can be burnt up or buried or thrown in the ocean its a person who they cannot defeat, but who can absolutely defeat them, and thats not going to be something that theyre going to be happy about, EP Michael Narducci says. Its going to make any kind of reconciliation all the more difficult. But Marcel, for his part, is always interested in doing the smart thing. Hes not motivated by revenge, hes not motivated by petty desire to take back something that he lost. When he sees the Mikaelsons again, hes going to make a very smart decision about how best to deal with them and thats one of the things I love about that character is watching the way his mind has evolved to transcend his upbringing.

Can you tease anything about the Bones finale? Mary I know theres a question of who survived that big explosion so the following teases could have many meanings, okay? First, Booth will take Brennan on an emotional walk down memory lane. Also, we finally find out the significance of 4:47. And finally, Cam hasnt been exactly honest with her coworkers about her time off from the Jeffersonian.

Any scoop on Riverdale? Taylor Even though Polly has taken refuge now living with Hermione and Veronica, that doesnt mean the Blossom parents have given up coming after her. Theyre like the child snatchers from Mary Poppins, EP Roberto Aquirre-Sacasa says. They want that baby more than anything.

Any chance of some Grimm scoop before it ends? Kelsey We are coming to the end here, so it shouldnt be surprising to hear that the death toll will be quite high as Nick finds himself fighting an unexpected person in the series finale. Hell also, of course, take on the Zerstrer, but hell have some equally unexpected help in that regard.

Im both terrified and beyond excited for Doomsworld on Legends of Tomorrow. What can you tease? Chris Well, the future beyond Doomsworld does not look promising heading into the finale. Were going to do the one thing on the show we said we would never do, EP Marc Guggenheim says of the season ender. Without spoiling too much, clearly theyre going to have to do something very significant and break a major rule in order to fix things.

Is Jane going to start dating soon on Jane the Virgin? Elena Prepare yourselves, Michael fans, because the answer is yes. In fact, the next episode is all about Jane getting her groove back and realizing that she might be ready to start dating again, and you might even recognize her first date. But lets just say that shes not the only one who realizes something big about her romantic life all three Villanueva women will have much to discuss in upcoming episodes.

This week in TV: I want thisRiverdaletheory to come true. So. Bad.

Thats a wrap on this weeks Spoiler Room. Be sure to email your questions to spoilerroom@ew.com or tweet them to @NatalieAbrams.

Additional reporting by Kelly Connolly, Samantha Highfill, and Sara Netzley.

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Spoiler Room: Scoop on Supergirl, Grey's Anatomy, Blindspot, and more - EW.com

Who’s the most annoying Grey’s Anatomy character: Maggie or Amelia? – A.V. Club

Because The A.V. Club knows that TV shows keep going even if were not writing at length about them, were experimenting with discussion posts. For certain shows, one of our TV writers will publish some brief thoughts about the latest episode, and open the comments for readers to share theirs.

Previous episode Even Greys Anatomy wants to get out of that damn hospital

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Who's the most annoying Grey's Anatomy character: Maggie or Amelia? - A.V. Club

BRIEF-Atossa Genetics files for public offering of up to 4 mln units – Reuters

MOVES-Deutsche Bank head of restructuring finance joins RBC -sources

March 23 Mark Cohen, the head of restructuring finance at Deutsche Bank AG, will join Royal Bank of Canada as head of its U.S. capital solutions group in New York in June, people familiar with the matter said on Thursday.

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BRIEF-Atossa Genetics files for public offering of up to 4 mln units - Reuters

First Mutations in Human Life Discovered – Laboratory Equipment – Laboratory Equipment

The earliest mutations of human life have been observed by researchers at the Wellcome Trust Sanger Institute and their collaborators. Analysing genomes from adult cells, the scientists could look back in time to reveal how each embryo developed.

Published in Nature, the study shows that from the two-cell stage of the human embryo, one of these cells becomes more dominant than the other and leads to a higher proportion of the adult body.

A longstanding question for researchers has been what happens in the very early human development as this has proved impossible to study directly. Now, researchers have analyzed the whole genome sequences of blood samples (collected from 279 individuals with breast cancer) and discovered 163 mutations that occurred very early in the embryonic development of those people.

Once identified, the researchers used mutations from the first, second and third divisions of the fertilized egg to calculate which proportion of adult cells resulted from each of the first two cells in the embryo. They found that these first two cells contribute differently to the whole body. One cell gives rise to about 70 percent of the adult body tissues, whereas the other cell has a more minor contribution, leading to about 30 percent of the tissues. This skewed contribution continues for some cells in the second and third generation too.

Originally pinpointed in normal blood cells from cancer patients, the researchers then looked for these mutations in cancer samples that had been surgically removed from the patients during treatment. Unlike normal tissues composed of multiple somatic cell clones, a cancer develops from one mutant cell. Therefore, each proposed embryonic mutation should either be present in all of the cancer cells in a tumor, or none of them. This proved to be the case, and by using these cancer samples, the researchers were able to validate that the mutations had originated during early development.

"This is the first time that anyone has seen where mutations arise in the very early human development. It is like finding a needle in a haystack. There are just a handful of these mutations, compared with millions of inherited genetic variations, and finding them allowed us to track what happened during embryogenesis," said Young Seok Ju, first author from the Wellcome Trust Sanger Institute and the Korea Advanced Institute of Science and Technology (KAIST).

"Having identified the mutations, we were able to use statistical analysis to better understand cell dynamics during embryo development. We determined the relative contribution of the first embryonic cells to the adult blood cell pool and found one dominant cell - that led to 70 percent of the blood cells - and one minor cell. We also sequenced normal lymph and breast cells, and the results suggested that the dominant cell also contributes to these other tissues at a similar level. This opens an unprecedented window into the earliest stages of human development," said Inigo Martincorena, from the Sanger Institute.

During this study, the researchers were also able to measure the rate of mutation in early human development for the first time, up to three generations of cell division. Previous researchers had estimated one mutation per cell division, but this study measured three mutations for each cell doubling, in every daughter cell.

Mutations during the development of the embryo occur by two processes - known as mutational signatures 1 and 5. These mutations are fairly randomly distributed through the genome, and the vast majority of them will not affect the developing embryo. However, a mutation that occurs in an important gene can lead to disease such as developmental disorders.

"This is a significant step forward in widening the range of biological insights that can be extracted using genome sequences and mutations. Essentially, the mutations are archaeological traces of embryonic development left in our adult tissues, so if we can find and interpret them, we can understand human embryology better. This is just one early insight into human development, with hopefully many more to come in the future," said Mike Stratton, lead author on the paper and director of the Sanger Institute.

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First Mutations in Human Life Discovered - Laboratory Equipment - Laboratory Equipment

Global Biochemistry Analyzers Market Forecast Research Report 2017 2021 – GreaterPatchogueDaily

The report Global Biochemistry Analyzers Market 2017 is a professional, in-depth study that includes insights extracted from complex information, which clients can use for their business advantage. A large volume of precise, reliable market data has been distilled into clear and actionable insight for clients so that they can formulate their plans or make crucial business decisions with precision.

The report begins with an overview of the Biochemistry Analyzers market and defines the trends that have shaped the global Biochemistry Analyzers market. The key market drivers, restraints, and opportunities that will shape the dynamics of the Biochemistry Analyzers market have been presented in the report. A detailed analysis of the key challenges the players in the market face has been also covered in the report. Key inputs from leading industry experts mentioned in the report address how these challenges can be turned into opportunities.

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A detailed segmentation analysis of the Biochemistry Analyzers market is available in the report. The key segments in the Biochemistry Analyzers industry along with their sub-segments have been covered in the report. The performance analysis of these segments and sub-segments has been included in the report along with detailed evaluation of the trends that will influence the growth prospects of these segments. Moreover, niche segments that demonstrate good growth potential and thus opportunities for new entrants and established companies in the market have been covered.

Market forecasts and estimates for each key segment and its sub-segments are available in the report. All estimates and forecasts in the Biochemistry Analyzers market study have been verified by the exhaustive primary research with the KIPs (key industry participants), which include the markets leading participants, key consumers and clients, and client distributors and vendors. A detailed company-wise analysis of the leading market players has also been covered in the Biochemistry Analyzers market report.

Inquiry for Buying Report @http://www.9dresearchgroup.com/report/113962/inquiry-for-buying

Analysis also covers upstream raw materials, equipment, downstream client survey, marketing channels, industry development trend and proposals. In the end, the report includes Biochemistry Analyzers new project SWOT analysis, investment feasibility analysis, investment return analysis, and development trend analysis. In conclusion, it is a deep research report on Global Biochemistry Analyzers industry. Here, we express our thanks for the support and assistance from Biochemistry Analyzers industry chain related technical experts and marketing engineers during Research Teams survey and interviews.

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Global Biochemistry Analyzers Market Forecast Research Report 2017 2021 - GreaterPatchogueDaily

Kate Walsh Let the Shade Fly About Shonda Rhimes and Grey’s Anatomy – Bravo (blog)

We love Shonda Rhimes. As far as we're concerned, every year is a Year of Yes. But when a star of not one but two of the prolific showrunner's series decides to willingly spill some tea about Shonda, of course we're going to be all ears.

That's exactly what Grey's Anatomy and Private Practice star Kate Walsh did when she appeared on Watch What Happens Live with Andy Cohen Wednesday night as she answered questions posed by the Shady Shonda Anaconda who slithered onto the screen.

Though Shonda is legendary for her gift giving, not every present has been a winner. "We once got, I think, just a box of potpourri," Kate said on WWHL. "We were like, 'Really? We just won every award known to man. That's cool. That's super cool.'"

Kate also revealed that she thought Grey's Anatomy jumped the shark during "the bomb episode," the Season 2 episode entitled "As We Know It." "But that's the one that made it everything, that made Grey's Anatomy," Kate explained. "I'd say she jumped that shark, but then we rode it all the way to the top."

So did Shonda ever throw any shade of her own? "Here's what I will say, we had on Private Practice, all I'll say is there was a no a-hole policy," Kate replied. "How about that?"

We guess we'll take it.

Watch Kate and her fellow WWHL guest Laura Dern spill some more Hollywood secrets, below.

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Kate Walsh Let the Shade Fly About Shonda Rhimes and Grey's Anatomy - Bravo (blog)