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Fertility clinics selling ‘ineffective’ IVF add-ons – International Federation of Gynecology and Obstetrics

A fertility watchdog has warned that women paying for IVF treatment are being pressured to pay for additional products. The Human Fertilisation and Embryology Authority has said that clinics are selling unneeded add-ons, but it is unable to prevent this.

Extra treatments being offered to women include drugs to prevent rejection, screening to choose the best embryo and procedures to result in better implantation. IVF treatment costs around 4,000 per course and these add-ons can cost between 100 and 3,500.

However, many of these treatments are ineffective, meaning clinics are getting women's hopes up about having a better chance of the process working. Oxford University research that was presented on BBC's Panorama at the end of last year showed that just one of the 27 treatments had any effect.

Sally Cheshire, chairof the Human Fertilisation and Embryology Authority, told a fertility conference in central London on March 29th that clinics offering these add-ons put more pressure on women who are already experiencing a lot of stress.

She said that the authority is concerned about the use of add-on treatments, but it cannot stop clinics from offering them or control the pricing.

Professor Adam Balen, chairman of the British Fertility Society, also spoke at the conference. He highlighted the fact that there is confusion for women over what is an actual add-on as many treatments that are being sold as add-ons are actually part of standard treatments, causing more confusion.

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Fertility clinics selling 'ineffective' IVF add-ons - International Federation of Gynecology and Obstetrics

Science Day brings students to campus – The Dartmouth

by Mika Jehoon Lee | 4/4/17 2:15am

Students from local schools with an interest in science read weather maps, planted seedlings and examined sheep brain specimens at the fifth annual Science Day held this past Saturday, April 1 at various labs on campus.

According to fourth-year biochemistry graduate student and Science Day co-organizer Jessica DeSimone, this years attendance was the highest since its launch in 2013. A total of 171 adults accompanied 231 students at the event this year. DeSimone said that close to 200 adults and 300 students RSVPd for the event, but inclement weather may have accounted for the gap between expected and actual attendance.

Science Day is a free, drop-in event that features 15-minute long scientific demonstrations and hands-on activities geared toward students in sixth to ninth grade. According to DeSimone, Science Day was created to educate local community members about science and foster students passion for the subject. DeSimone said that Science Day was hosted by the group Graduate Women in Science and Engineering over the past few years, but this year it was independently organized by DeSimone, sixth-year biochemistry student Kelly Salmon and second-year biochemistry student Sarah Valles due to leadership changes in the group. They received funding for this years event from the School of Graduate and Advanced Studies. In addition to the three organizers, around 60 graduate students from eight different departments including biology, chemistry and psychology prepared 11 total activity stations for the event this year.

In the under the microscope station, students watched worms and flies glow under microscopes. According to third-year cellular and molecular biology graduate student Timothy Gauvin, a volunteer at the station, worms and flies provide a simple system for studying various human diseases, because the three species share a lot of similarities. Gauvin added that his love for microscopes got him interested in science and that he hoped students exposure to the activity would inspire their passion for science.

I thought it was cool to look at human cells under [microscopes] and as I investigated further, there was a lot of cool stuff you could do with this, Gauvin said. Im hoping kids of various ages can see that we have a lot of cool tricks.

Local middle school student Hope Cooper, who visited the under the microscope station, said that she enjoyed looking at worms under the microscope and learning about how worms hatch. Both Cooper and her father Adam Cooper attended Science Day two years ago and said that there were more microscopes and opportunities for students to use them this year than in years past.

Adam Cooper spoke highly of the benefit of such an event for students in exposing them to subjects they might study or pursue in the future.

The exposure for our kids to see what interests they may or may not have, to be able to see what they might want to do when they grow up and what they might not want to do when they grow up, [is] just a lot of good exposure to what their future might be, Adam Cooper said.

Meanwhile, in the soil and the world beneath our feet station, volunteers including ecology, evolution, ecosystems and society graduate student Ashley Lang Gr20 helped kids learn about mycorrhizal fungi and fossils. Lang said she wanted to introduce students to mycorrhizae, which grow in symbiotic relationships with plants, because it is poorly understood and many people are unaware of its existence.

Local elementary school student Nicholas Champine said that he enjoyed participating in Langs station and appreciated learning about fungis influence on plant growth.

Local elementary school student Charleigh Olmstead said that he specifically enjoyed playing the game Jet Stream Racer in the flowing rivers of air station. According to earth science graduate student Huanping Huang, the game allows students to become pilots and learn more about jet streams and gas. Jag Olmstead, Charleighs father, said that Science Day provided an opportunity of intellectual engagement for his children, as opposed to more typical recreational activities.

[Science Day] is something for the kids to enlighten their minds, learn something new and not play video games, Jag Olmstead said.

Rong Ding, whose elementary school-aged son participated in the flowing rivers of air station, said that the event provided his son with a unique opportunity to witness and participate in scientific experiments, which is not an everyday occurrence.

Science Day attendees were also given tours of the Thayer School of Engineering, where they visited the schools laboratories and made flubber, a rubbery polymer.

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Science Day brings students to campus - The Dartmouth

Michelangelo’s Medici Chapel may contain hidden symbols of … – Phys.Org

April 4, 2017 Highlight showing the sides of the tombs containing the bull/ram skulls, spheres/circles linked by cords and the shell (A). Note the similarity of the skull and horns to the uterus and fallopian tubes, respectively (B). The shell contained in image A clearly resembles the shell contained in Sandro Botticelli's "The Birth of Venus" (1483), Galleria degli Uffizi, Florence, Italy (C). Image B of the uterus and adnexa from Netter's Atlas of Human Anatomy with permission Philadelphia: Elsevier. Credit: Clinical Anatomy

Michelangelo often surreptitiously inserted pagan symbols into his works of art, many of them possibly associated with anatomical representations. A new analysis suggests that Michelangelo may have concealed symbols associated with female anatomy within his famous work in the Medici Chapel.

For example, the sides of tombs in the chapel depict bull/ram skulls and horns with similarity to the uterus and fallopian tubes, respectively.

Numerous studies have offered interpretations of the link between anatomical figures and hidden symbols in works of art not only by Michelangelo but also by other Renaissance artists.

"This study provides a previously unavailable interpretation of one of Michelangelo's major works, and will certainly interest those who are passionate about the history of anatomy," said Dr. Deivis de Campos, lead author of the Clinical Anatomy article. Another recent analysis by Dr. de Campos and his colleagues revealed similar hidden symbols in Michelangelo's Sistine Chapel.

Explore further: Michelangelo's Sistine Chapel may contain hidden symbols of female anatomy

More information: Deivis de Campos et al, Pagan symbols associated with the female anatomy in the Medici Chapel by Michelangelo Buonarroti, Clinical Anatomy (2017). DOI: 10.1002/ca.22882

Publications on the works of Michelangelo in the Sistine Chapel indicate that numerous codes and hidden messages may have been inserted for various purposes.

New research provides mathematical evidence that Michelangelo used the Golden Ratio of 1.6 when painting The Creation of Adam on the ceiling of the Sistine Chapel. The Golden Ratio is found when you divide a line into two ...

Da Vinci Code author Dan Brown has yet to write a book on the hidden pictures in Michelangelo's artwork, but maybe he can start working on a thriller that takes Robert Langdon on a journey through the Renaissance master's ...

Prolonged hammering and chiselling accelerated degenerative arthritis in the hands of Michelangelo Buonarroti, sculptor, painter and one of the greatest artists of all time. But the intense work probably helped him keep the ...

Michelangelo's famous Sistine Chapel ceiling paintings in the Vatican have been brought to life with innovative light emitting diode (LED) lighting. The new installation, developed by the EU-funded LED4ART project, enables ...

Engineers and imagers from the University of Warwick's Warwick Manufacturing Group (WMG) and anatomists from Warwick Medical School at the University of Warwick are helping Art historians from the University of Cambridge ...

Approximately 13,500 years after nomadic Clovis hunters crossed the frozen land bridge from Asia to North America, researchers are still asking questions and putting together clues as to how they not only survived in a new ...

A study of the DNA in ancient skeletal remains adds to the evidence that indigenous groups living today in southern Alaska and the western coast of British Columbia are descendants of the first humans to make their home in ...

A cave in southern Oregon that is the site of some the oldest preserved evidence of human activity in North America was also once home to not-too-distant cousins of the common bed bug.

Reader preferences for liberal or conservative political books also attract them to different types of science books, according to a new study from researchers at the University of Chicago and Yale and Cornell universities. ...

Two monkeys grooming each other about 20-30 million years ago may have helped produce a remarkable new find - the first fossilized red blood cells from a mammal, preserved so perfectly in amber that they appear to have been ...

The Australian Research Centre for Human Evolution (ARCHE) team, based in Griffith's Environmental Futures Research Institute, together with Indonesian colleagues, have shed new light on 'Ice Age' human culture and symbolism ...

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Michelangelo's Medici Chapel may contain hidden symbols of ... - Phys.Org

Anatomy of a fake scandal, ginned up by right-wing media and Trump – Washington Post (blog)

President Trump started off this morning as he often does, by settling in to watch the festival of nincompoopery that is Fox & Friends. On the show, he saw something that he believes vindicates the bizarre and false charge he made that Barack Obama was tapping his phones during the presidential campaign.

Ill try to sort through the substance of all this. But I also want to make a broader argument about how Trumps support system inside his government but especially in the conservative media and on Fox, which is where he apparently gets most of his intelligence information is playing to his worst instincts, harming him politically, and making his presidency even more dangerous.

Todays antics all started with a report on Fox & Friends in which correspondent Adam Housley reported that a high-ranking Obama administration official had requested the unmasking of the names of Trump officials who were caught up in surveillance of foreign targets. Ordinarily, when a U.S. person shows up in such surveillance say, talking to a Russian ambassador whose communications are being monitored that persons identity is blacked out in reports on the surveillance. While Housley did not identify the Obama administration official, he did say that Trump associates were being picked up by this surveillance for a year before Trump took office.

Then we get this report from Eli Lake, identifying former national security adviser Susan Rice as the Obama official who requested the unmasking. Id like to highlight this passage:

Rices requests to unmask the names of Trump transition officials does not vindicate Trumps own tweets from March 4 in which he accused Obama of illegally tapping Trump Tower. There remains no evidence to support that claim.

But Rices multiple requests to learn the identities of Trump officials discussed in intelligence reports during the transition period does highlight a longstanding concern for civil liberties advocates about U.S. surveillance programs. The standard for senior officials to learn the names of U.S. persons incidentally collected is that it must have some foreign intelligence value, a standard that can apply to almost anything. This suggests Rices unmasking requests were likely within the law.

Id say that if members of the Trump team were in communication with foreign actors who were under surveillance, that damn sure has foreign intelligence value, and its not too surprising that the national security adviser would want to know about it. Were talking about associates of a presidential candidate communicating with representatives of a foreign power.

Lets back up for a moment and go through the series of events here to get some context. Heres what has happened, with the caveat that some of the information is sketchy:

1. On March 4, President Trump sends out a series of tweets claiming that Barack Obama tapped his phones, apparently because of an article Trump saw on Breitbart. In subsequent days, the FBI director, the NSA director, the former director of national intelligence and everyone in any position to know make clear that not only didnt Obama tap Trumps phones, the president has no power to order phone-tapping.

White House press secretary Sean Spicer has been repeatedly defending President Trump's unproven claims that former president Barack Obama ordered a wiretap on him in 2016. (Bastien Inzaurralde/The Washington Post)

2.Because Trump never backs down from even the most ridiculous lie, his employees and allies are now required defend his claim. So spokesperson Sean Spicer argues that because in a different tweet Trump put the words wire tapping in quotes, that means he was referring to a whole host of surveillance types and not his phones being tapped, despite the fact that he said President Obama was tapping my phones. Trump himself will later pick up this argument.

3.Two White House officials, Ezra Cohen-Watnick and Michael Ellis, locate intelligence reports that include Trump officials in communication with Russians under surveillance by American intelligence agencies. The White House says they came across those reports in the ordinary course of business and were not actually looking for something that would back up Trumps claim; you can decide how plausible you find that. In any case, they then call Rep. Devin Nunes, the chair of the House Intelligence Committee, to the White House so he can view the information. Nunes then holds a news conference announcing the find and briefs Trump on what Trumps own staff has told him.

All of this was designed to allow Trump to say that he was right all along that he was being targeted by Obama, which of course he does.

4. Im skipping over some smaller developments and plenty of details. But today, we have the following series of events: Trump officials leak that Rice requested the unmasking of the identities of Trump associates who were in communication with foreigners under surveillance; those reporters publish their stories; then the president himself calls attention to them on his Twitter feed:

This particular PR maneuver is not unprecedented, but the point is this: Whats obviously of most importance to the president of the United States isnt the fact that his associates were in contact with people from Russia (or other countries) who were of sufficient interest to U.S. intelligence that they would be under surveillance, but whether or not each new detail that emerges does or does not support his idiotic tweets.

And this is why I argue that Fox and some of Trumps allies are only helping him hurt himself. Much of the time, having a supportive amen chorus has great political utility, because it helps buck up your base and disseminate the arguments youre making. But its one thing when those arguments are things like We should cut taxes or Obamacare is a disaster. Its something else when theyre trying desperately to claim that every stupid thing Trump ever said is actually true.

In this case, clinging to the idea that the Obama administration unfairly monitored the Trump campaign only encourages further investigation of what could turn out to be one of the biggest scandals in American political history. Nuness buffoonish efforts on Trumps behalf havent helped him at all. Quite the contrary, theyve made his committee utterly irrelevant and increased pressure on the Senate Intelligence Committee to conduct a thorough and objective review. Nunes has zero credibility, and so he can no longer be an asset to the White House.

But when Trump tunes in to Fox & Friends every morning, he learns that hes right about everything. He doesnt need to listen to his intelligence briefers or anyone else who might tell him something he doesnt want to hear. He can keep telling tall tales and pursuing his petty grievances. He never does anything wrong and never has to change. I shudder to think how that dynamic will play out when this administration faces its first foreign policy crisis, with untold numbers of lives at stake.

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Anatomy of a fake scandal, ginned up by right-wing media and Trump - Washington Post (blog)

Prior Scientific offers new ultra-stable platform for neuroscience and … – News-Medical.net

April 3, 2017 at 3:55 AM

Prior Scientific announces V-Deck - an ultra-stable platform for neuroscience and electrophysiology that offers you the ability to quickly and precisely adjust sample height.

The new V-Deck sets a new benchmark for operational stability. Versatility to optimally image from thin sections right through to whole animal samples is ensured through the available of a wide range of height adjustable, lockable platform posts.

The V-Deck offers a large sample area, with a M6 x 25 breadboard, that allows heating, cooling, perfusion and incubation chambers, micromanipulators, stereotaxic instruments and other equipment to be precisely mounted. Consequently setting up microscopic imaging of an electrophysiology or neuroscience experiment to your exact specifications is quickly and routinely achievable.

Dovetail slides on the V-Deck enable the horizontal position of your sample to be simply and rapidly adjusted. The entire V-Deck platform is compatible with almost any commercially available vibration isolation table.

The V-Deck is designed to be used on conjunction with the recently released Prior Scientific Translation stage. The Translation stage allows an entire microscope to be quickly yet precisely moved, allowing your sample to remain immobile - essential for precision electrophysiology and neuroscience experiments where it is vital for the sample to stay completely still and as vibration free as possible.

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Prior Scientific offers new ultra-stable platform for neuroscience and ... - News-Medical.net

Invisible Manipulators of Your Mind | by Tamsin Shaw | The New … – The New York Review of Books

The Undoing Project: A Friendship That Changed Our Minds

by Michael Lewis

Norton, 362 pp., $28.95

We are living in an age in which the behavioral sciences have become inescapable. The findings of social psychology and behavioral economics are being employed to determine the news we read, the products we buy, the cultural and intellectual spheres we inhabit, and the human networks, online and in real life, of which we are a part. Aspects of human societies that were formerly guided by habit and tradition, or spontaneity and whim, are now increasingly the intended or unintended consequences of decisions made on the basis of scientific theories of the human mind and human well-being.

The behavioral techniques that are being employed by governments and private corporations do not appeal to our reason; they do not seek to persuade us consciously with information and argument. Rather, these techniques change behavior by appealing to our nonrational motivations, our emotional triggers and unconscious biases. If psychologists could possess a systematic understanding of these nonrational motivations they would have the power to influence the smallest aspects of our lives and the largest aspects of our societies.

Michael Lewiss The Undoing Project seems destined to be the most popular celebration of this ongoing endeavor to understand and correct human behavior. It recounts the complex friendship and remarkable intellectual partnership of Daniel Kahneman and Amos Tversky, the psychologists whose work has provided the foundation for the new behavioral science. It was their findings that first suggested we might understand human irrationality in a systematic way. When our thinking errs, they claimed, it does so predictably. Kahneman tells us that thanks to the various counterintuitive findingsdrawn from surveysthat he and Tversky made together, we now understand the marvels as well as the flaws of intuitive thought.

Kahneman presented their new model of the mind to the general reader in Thinking, Fast and Slow (2011), where he characterized the human mind as the interrelated operation of two systems of thought: System One, which is fast and automatic, including instincts, emotions, innate skills shared with animals, as well as learned associations and skills; and System Two, which is slow and deliberative and allows us to correct for the errors made by System One.

Lewiss tale of this intellectual revolution begins in 1955 with the twenty-one-year-old Kahneman devising personality tests for the Israeli army and discovering that optimal accuracy could be attained by devising tests that removed, as far as possible, the gut feelings of the tester. The testers were employing System One intuitions that skewed their judgment and could be avoided if tests were devised and implemented in ways that disallowed any role for individual judgment and bias. This is an especially captivating episode for Lewis, since his best-selling book, Moneyball (2003), told the analogous tale of Billy Beane, general manager of the Oakland Athletics baseball team, who used new forms of data analytics to override the intuitive judgments of baseball scouts in picking players.

The Undoing Project also applauds the story of the psychologist Lewis Goldberg, a colleague of Kahneman and Tversky in their days in Eugene, Oregon, who discovered that a simple algorithm could more accurately diagnose cancer than highly trained experts who were biased by their emotions and faulty intuitions. Algorithmsfixed rules for processing dataunlike the often difficult, emotional human protagonists of the book, are its uncomplicated heroes, quietly correcting for the subtle but consequential flaws in human thought.

The most influential of Kahneman and Tverskys discoveries, however, is prospect theory, since this has provided the most important basis of the biases and heuristics approach of the new behavioral sciences. They looked at the way in which people make decisions under conditions of uncertainty and found that their behavior violated expected utility theorya fundamental assumption of economic theory that holds that decision-makers reason instrumentally about how to maximize their gains. Kahneman and Tversky realized that they were not observing a random series of errors that occur when people attempted to do this. Rather, they identified a dozen systematic violations of the axioms of rationality in choices between gambles. These systematic errors make human irrationality predictable.

Lewis describes, with sensitivity to the political turmoil that constantly assailed them in Israel, the realization by Kahneman and Tversky that emotions powerfully influence our intuitive analysis of probability and risk. We particularly aim, on this account, to avoid negative emotions such as regret and loss. Lewis tells us that after the Yom Kippur War, Israelis deeply regretted having to fight at a disadvantage as a result of being taken by surprise. But they did not regret Israels failure to take the action that both Kahneman and Tversky thought could have avoided war: giving back the territorial gains from the 1967 war. It seemed to Kahneman and Tversky that in this case as in others people regretted losses caused by their actions more than they regretted inaction that could have averted the loss. And if this were generally the case it would regularly inform peoples judgments about risk.

That research eventually yielded heuristics, or rules of thumb, that have now become well-known shorthand expressions for specific flaws in our intuitive thinking. Some of these seem to be linked by a shared emotional basis: the endowment effect (overvaluation of what we already have), status quo bias (an emotional preference for maintaining the status quo), and loss aversion (the tendency to attribute much more weight to potential losses than potential gains when assessing risk) are all related to an innate conservatism about what we feel we have already invested in.

Many of these heuristics are easy to recognize in ourselves. The availability heuristic describes our tendency to think that something is much more likely to occur if we happen to be, for contingent reasons, strongly aware of the phenomenon. After September 11, for instance, fear of terrorism was undoubtedly disproportionate to the probability of its occurrence relative to car crashes and other causes of death that were not flashing across our TV screens night and day. We find it hard to tune out information that should, strictly speaking, not be of high relevance to our judgment.

But in spite of revealing these deep flaws in our thinking, Lewis supplies a consistently redemptive narrative, insisting that this new psychological knowledge permits us to compensate for human irrationality in ways that can improve human well-being. The field of behavioral economics, a subject pioneered by Richard Thaler and rooted in the work of Kahneman and Tversky, has taken up the task of figuring out how to turn us into better versions of ourselves. If the availability heuristic encourages people to ensure against very unlikely occurrences, nudges such as providing vivid reminders of more likely bad outcomes can be used to make their judgments of probability more realistic. If a bias toward the status quo means that people tend not to make changes that would benefit them, for instance by refusing to choose between retirement plans, we can make the more beneficial option available by automatically enrolling people in a plan with the option to withdraw if they choose.

This is exactly what Cass Sunstein did when when he oversaw the Office of Information and Regulatory Affairs in the Obama White House (Obama subsequently created a Social and Behavioral Sciences Team). He devised choice architectures or nudges that would work with the intuitive apparatus people have in order to guide their choices. In Lewiss hands, the potential for doing good through such means can be a kind of magic, stealing like moonlight through the homes of sleeping Americans:

Millions of US corporate and government employees had woken up one day during the 2000s and found they no longer needed to enroll themselves in retirement plans but instead were automatically enrolled.

Sunstein and Thaler have described the political philosophy of such interventions as Libertarian Paternalism. It is libertarian because they do not impose mandates to narrow peoples choice, but merely frame choices or provide incentives that tend to make people better off, as judged by themselves. Their claim is that this form of influence, albeit often unconscious, is not manipulative or coercive because the possibility of a person choosing differently is not closed down. Lewiss book ends with an uncomplicated celebration of this form of guided but purportedly free choice.

Lewis does not discuss the ways in which the same behavioral science can be used quite deliberately for the purposes of deception and manipulation, though this has been one of its most important applications. Frank Babetski, a CIA Directorate of Intelligence analyst who also holds the Analytical Tradecraft chair at the Sherman Kent School of Intelligence Analysis at the CIA University, has called Kahnemans Thinking, Fast and Slow a must read for intelligence officers.

Babetski has described the use of behavioral science for deceptive practices that are part of the intelligence officers trade.1 He is envisaging this use as constrained by law and by intelligence goals that are ultimately determined by democratic governments. But in doing so he also reveals the potential for coercion that is implicit in these tools for anyone willing to wield it.

The deeper concern that Lewiss happy narrative omits entirely is that behavioral scientists claim to have developed the capacity to manipulate peoples emotional lives in ways that shape their fundamental preferences, values, and desires. In Kahnemans recent work he has developed the idea, originally set out in one of his papers with Tversky (who died in 1996), that we are not good judges of our own well-being. Our intuitions are unstable and conflicting. We may retrospectively judge an experience more enjoyable than our subjective reports suggested at the time. Kahneman, working with others in the field of positive psychology, has helped to establish a new subfield, hedonic psychology, which measures not just pleasure but well-being in a broader sense, in order to establish a more objective account of our condition than our subjective reflection can afford us.

This new subfield has led the way in combining research in behavioral science with big data, a further development that is beyond the scope of Lewiss book, but one that has tremendously expanded the potential applications of Kahneman and Tverskys ideas. Psychologists at the World Well-Being Project, at the University of Pennsylvania, have collaborated with Michal Kosinski and David Stillwell, computational psychologists from the Psychometrics Centre at the University of Cambridge and developers of myPersonality. This was a Facebook application that allowed users to take psychometric tests and gathered six million test results and four million individual profiles. Scores on these tests could be combined with enormous amounts of data from the users Facebook environment. The application has been used in conjunction with personality measures such as the big five, also known as the OCEAN model, which purportedly measures openness, conscientiousness, extraversion, agreeableness, and neuroticism. Words such as apparently and actually, for example, are taken to correlate with a higher degree of neuroticism. The architects of myPersonality claim that these tests, in conjunction with other data, permit the prediction of individual levels of well-being.

The guiding idea for the World Well-Being Project is that we need not rely on our faulty subjective judgments about what will make us happy or what path in life will give us a sense of meaning.2 But if those studying behavioral influence are targeting the form of well-being that we value and the kind of happiness we seek, then it is harder to see how peoples being better off, as judged by themselves genuinely preserves their freedom. And this concern is not a purely academic one. The manipulation of preferences has driven the commercialization of behavioral insights and is now fundamental to the digital economy that shapes so much of our lives.

In 2007, and again in 2008, Kahneman gave a masterclass in Thinking About Thinking to, among others, Jeff Bezos (the founder of Amazon), Larry Page (Google), Sergey Brin (Google), Nathan Myhrvold (Microsoft), Sean Parker (Facebook), Elon Musk (SpaceX, Tesla), Evan Williams (Twitter), and Jimmy Wales (Wikipedia).3 At the 2008 meeting, Richard Thaler also spoke about nudges, and in the clips we can view online he describes choice architectures that guide people toward specific behaviors but that can be reversed with one click if the subject doesnt like the outcome. In Kahnemans talk, however, he tells his assembled audience of Silicon Valley entrepreneurs that primingpicking a suitable atmosphereis one of the most important areas of psychological research, a technique that involves offering people cues unconsciously (for instance flashing smiley faces on a screen at a speed that makes them undetectable) in order to influence their mood and behavior. He insists that there are predictable and coherent associations that can be exploited by this sort of priming. If subjects are unaware of this unconscious influence, the freedom to resist it begins to look more theoretical than real.

The Silicon Valley executives clearly saw the commercial potential in these behavioral techniques, since they have now become integral to that sector. When Thaler and Sunstein last updated their nudges.org website in 2011, it contained an interview with John Kenny, of the Institute of Decision Making, in which he says:

You cant understand the success of digital platforms like Amazon, Facebook, Farmville, Nike Plus, and Groupon if you dont understand behavioral economic principles. Behavioral economics will increasingly be providing the behavioral insight that drives digital strategy.

And Jeff Bezos of Amazon, in a letter to shareholders in April 2015, declared that Amazon sellers have a significant business advantage because through our Selling Coach program, we generate a steady stream of automated machine-learned nudges (more than 70 million in a typical week). It is hard to imagine that these 70 million nudges leave Amazon customers with the full freedom to reverse, after conscious reflection, the direction in which they are being nudged.

Facebook, too, has embraced the behavioral insights described by Kahneman and Thaler, having received wide and unwanted publicity for researching priming. In 2012 its Core Data Science Team, along with researchers at Cornell University and the University of California at San Francisco, experimented with emotional priming on Facebook, without the awareness of the approximately 700,000 users involved, to see whether manipulation of their news feeds would affect the positivity or negativity of their own posts. When this came to light in 2014 it was generally seen as an unacceptable form of psychological manipulation. But Facebook defended the research on the grounds that its users consent to their terms of service was sufficient to imply consent to such experiments.

Nathan Myhrvold, the former chief technology officer of Microsoft who attended Kahnemans masterclasses in 2007, went on to become an adviser to Kahnemans own consulting firm, TGG Group, chaired by the former Citibank head Vikram Pandit. This group aims, according to its website, to unpack the knowledge hidden in big data, designchoice architectures, and reduce noise in decision-making (that is, to eliminate inconsistencies created by conflicting subjective judgments in organizations).

The website does not list any of TGGs clients, though early articles mention its pitching Deutsche Bank. In conjunction with big data, behavioral science has become an extraordinarily powerful tool in the world of business and finance, and Kahneman has not shied away from these applications. Lewiss book ends with the thrill of the phone ringing in Kahnemans living room on an October morning in 2002, as we anticipate the announcement that he has won the Nobel Prize for his work with Tversky. But the story of their ideas silently transforming our social world, in conjunction with data we supply, has only just begun.

Since the electoral surprise of November 8, 2016, the magical tale of behavioral science making the world a better place has been replaced by a darker story in the public mind. It has been widely reported that Trumps team, as adviser Jared Kushner puts it, played Moneyball with the election. News outlets have claimed that although Obamas and Clintons teams both used social media, data analytics, and finely grained targeting to promote their message, Trumps team, according to Forbes, delved into message tailoring, sentiment manipulation and machine learning.4 If this sinister level of manipulation seems far-fetched, it nevertheless reflects the boasts of Cambridge Analytica, the company they employed to do this for them, a subsidiary of the British-based SCL Group.

The company, whose board has included Trumps chief strategist, Steve Bannon, has also been held responsible by the press for the outcome of the Brexit vote of June 2016. Its CEO, Alexander Nix, claims in a presentation entitled The Power of Big Data and Psychographics (which can be found on Youtube5) that Cambridge Analytica has used OCEAN personality tests in combination with data mined from social media to produce psychographic profilesmodels that predict personality traitsfor every adult in America. It did so without the consent of Kosinski and Stillwell, who developed the technique. Nix claims that they possess between four and five thousand data points on every potential voter, after combining the personality test results with attitudinal data, such as credit card spending patterns, consumer preferences, Facebook likes, and civic and political engagement.

There is an interesting slippage in the presentation between Nix saying that hundreds of thousands of people have filled out Cambridge Analyticas questionnaires and his claiming they have this amount of data on every American adult. It is either an empty boast or there is a disturbing story to be told about how they acquired this information. Nix nevertheless claims that they can use their data in combination with tracking cookies, data from cable companies, and other media tools to target very specific audiences with messages that are persuasive because they are informed by behavioral science.

In describing their behavioral methods of persuasion, Nix gives the example of a private beach owner who wishes to keep the public out. He might, Nix says, put up an informational sign that seeks to inform attitudes, such as: Public beach ends here: private property. Or he could seek to probe an altogether much more powerful, underlying motivation by putting up a sign that says Warning: shark sighted. The threat of being eaten by a shark, Nix claims, will be more effective. Similarly, in videos made by Cambridge Analyticas research wing, the Behavioral Dynamics Institute, the group describes strategies for appealing directly to peoples underlying fears and desires in ways that are continuous with the insights of behavioral economics, but that seem less scrupulous about employing lies or half-truths to influence System One motivations.

This behavioral microtargeting is what Nix claims to have used when Cambridge Analytica worked on the Cruz campaign. But it is important to remember that this much-discussed video is a sales pitch.

Behavioral techniques, microtargeting, and data analysis are not new to political campaigns, as Sasha Issenberg has shown in The Victory Lab: The Secret Science of Winning Campaigns (2012). Accurate and detailed psychographic profiles are a product that everyone in this business wants, so thats what Nix claims to be selling. Doubts have been raised about whether the Trump team in fact employed these techniques, though the Cambridge Analytica website has posted articles asserting that they did. There has also been some skepticism about whether the psychographic techniques Nix describes actually work.6

It is impossible to test the claims of organizations such as Cambridge Analytica, since there can be no control group, only the kind of ambiguous observational data that can be attained in a very noisy environment. But this doesnt mean that there is no threat to democracy once we start relying less on information that can be critically scrutinized in favor of unconscious manipulation.

Whatever the truth of Cambridge Analyticas claims, the very existence of such companies tells us something important about the weight that unconscious influence, relative to reasoned argument, now plays in political campaigns. Kahnemans TGG Group is not involved in the business of political influence. But according to Issenberg, in 2006, a private group at the University of California, Los Angeles, called the Consortium of Behavioral Scientists, which was run by psychologist Craig Fox and included Kahneman and Thaler, began to persuade Democrats that they needed to employ behavioral science. The secrecy of the group was a result of qualms about how such initiatives would be perceived. By now, behavioral strategies are in the open and are ubiquitous. The term propaganda has been replaced by a behavioral approach to persuasive communication with quantifiable results.

Companies such as SCL Group claim to have the weapons to win large-scale ideological struggles. We can watch online a video of Nigel Oakes, the head of SCL Group, delivering a presentation to the US Department of State on behalf of SCL Defence, one of its subsidiaries. He points out that traditional advertisers who appeal to individuals and capture 0.6 percent of their market are considered very successful. Strategic communication, however, requires group communication: Theres no point in having .6 percent of Syrians supporting you or .6 percent of al-Qaeda. Weve got to convince the entire communities.7 The part of the pitch in which he describes his methods is not available for public viewing.

The claim that SCL can deliver this is an extraordinary one, even for a company that has experience in the field through psychological operations led by Steve Tatham, a former commander in the British navy. He worked, for example, with Andrew Mackay, the commander of the British armed forces in Afghanistan, in order to win areas that had been flattened by kinetic activity through persuasive techniques derived from behavioral economics and refined in theater.8

Many of the relevant techniques were suggested directly by Kahneman and Tversky in their 1995 essay Conflict Resolution: A Cognitive Perspective. Tatham and Mackay, in a book on their initiatives, Behavioral Conflict: Why Understanding People and Their Motivations Will Prove Decisive in Future Conflict (2011), describe how they were used in the Afghan war. They employed prospect theory, for example, to think about motivations, realizing that the avoidance of further losses was more important to local populations than the potential realization of gains. The reconstruction of the Kajaki Dam in Helmand, while strategically important, was too remote an incentive to limit insurgent activity around the dam. More immediate incentives had to be created. Kahneman and Tverskys insight into the wisdom of crowds was employed when thinking about decision-making in an Afghan shura, or assembly, where the British sought to empower those individuals who had the right ideas but the least amount of authority.

We cannot, however, gather data on the successes of these initiatives, since the psychological factors involved are opaque and the counterfactuals impossibly complex. When the party wishing to persuade a population arrives with tanks, guns, and drones, and the population itself is internally divided, we cannot easily determine the extent to which cooperation with the occupying forces is the result of behavioral techniques. There is as yet no scientific evidence of how the military can noncoercively influence group behavior on a large scale in zones of conflict. And claims about winning over the majority of a population in any given state are entirely untested.

Nevertheless, SCL Group, which claims to have mastered behavioral influence both online and in the field, recently signed a $500,000 contract with the State Department and according to The Washington Post is in negotiations with the Trump administration to help the Pentagon and other government agencies with counter radicalization program.9 They claim to have offers for their services from all over the world. This in turn will doubtless engender competition from around the world.

The idea of Libertarian Paternalism, in which the tools of the new behavioral sciences remain in the hands of benign liberal mandarins, has come to seem hopelessly quaint. In a more combative and unstable environment there must clearly be greater concern about our capacity to regulate the uses of behavioral science, the robustness of the fundamental research, and the political or financial motivations of any behavioral initiatives to be employed or countered.

Nonrational forms of persuasion are clearly nothing new. But many social psychologists credit Kahneman and Tversky with a profoundly original theory of the human mind, one that exposes systematic, unconscious sources of irrationality, just as Freuds idea of the unconscious was taken to do by previous generations of psychologists. The view that social psychology and behavioral economics are rooted in robust fundamental research of this kind lends the imprimatur of cutting-edge science to the millions of behavioral initiatives now being undertaken across the world.

When Kahnemans Thinking, Fast and Slow was published in 2011, it elicited comparisons to the innovations of Descartes, Darwin, and Freud. But philosophers have long had qualms about the two-systems model Kahneman sets out there. In 1981, L. Jonathan Cohen published a paper entitled Can Human Irrationality Be Experimentally Demonstrated? In it he developed various lines of criticism of Kahneman and Tverskys work, but the one to which Kahneman was particularly moved to respond was the idea that we cannot easily separate intuition from other cognitive functions, that we in fact have no choice but to rely on intuition in our reasoning.

Kahneman rejected the idea that there can be a realm of intuition that cannot be rationally evaluated because people often find inconsistent intuitions appealing.10 If our intuitions conflict, rational deliberation will have to be called upon to adjudicate the disagreement. However, in his ongoing defense of this position he has failed to take into account what Cohen and other philosophers mean by intuition, and so failed to engage the sense in which intuitions are necessary for deliberation.

In Thinking, Fast and Slow, Kahneman characterizes System One intuitions as fast and automatic, whereas System Two reasoning is slow and deliberate. In other words, he characterizes our intuitive judgments phenomenologically, by describing the speed and effortlessness with which they come to us. They are, in effect, snap judgments.When philosophers describe our reliance on intuition, however, they are not concerned with the phenomenology of judgments per se but with the architecture of justification.

We have to rely on intuition, they contend, where our discursive justifications come to an end, for instance in the fundamental laws of logic, such as the principle of noncontradiction, or basic rules of inference. We cannot justify our belief in these laws in ways that dont beg further questions. Our justification for employing them rests on our finding them self-evident. We cannot deliberate rationally without them. Since they are the necessary basis for any deliberative thought, we cannot characterize mental functions as straightforwardly belonging to an intuitive System One or a deliberative System Two.

A further problem arises when we try to assign errors to a particular set of systematic biases, or attribute them to specific flawed heuristics. If we wish to accuse someone employing the word probable or likely of making a false probabilistic judgment, we need to be sure that they are employing the very same concept of probability that is the object of analysis in probability theory. If we wish to accuse someone of making false probabilistic judgments because they are employing a faulty heuristic, we need to be sure that the correct explanation isnt that certain people have some complicating beliefs in the background, in luck or fate or God, for instance.

Similarly, when peoples judgments appear to be affected by irrelevant stimuli, for example a reminder of our mortality seeming to make us more risk-averse (priming effects, that is), a very large number of potential causal factors would have to be ruled out before such irrational biases could be confidently described as features intrinsic to System One. If it is not a simple task to divide thinking into two separate systems, it will not be easy to reduce the complex interactions between unconscious biases, background beliefs, and deliberation in any given case to an identifiable and systematic error.

These objections, if correct, would suggest that many of the psychological experiments Kahneman cites in Thinking, Fast and Slow would be impossible to replicate. And indeed the very year that it was published a replicability crisis emerged in the field of psychology, but most severely in social psychology. The psychologist Ulrich Schimmack has recently created a Replicability Index that analyzes the statistical significance of published results in psychology. He and his collaborators, Moritz Heene and Kamini Kesavan, have applied this to the studies cited in Thinking, Fast and Slow to predict how replicable they will be, assigning letter grades to each chapter. Kahneman and Tverskys own work gets good grades, but many other studies fare very poorly. The chapter on priming, for example, gets an F.11 As reported in Slate, the overall grade of the chapters assessed so far is a C-.12 Kahneman has posted a gracious response to their findings, regretting that he cited studies that used such small sample sizes.13

This seems to represent a serious challenge to the biases and heuristics approach to persuasion. Psychologists have not yet uncovered the fundamental mechanisms governing human thought or finally found the secret key to mind control. Since the human mind is not straightforwardly a mechanism (or we are at least far from proving that it is) and its workings are unfathomably complex so far, they may never succeed in that venture. Some of the biases they have identified can easily be redescribed in ways that dont make them seem like irrational biases at all; some are not transferable across different environments. The fundamental assumption of two discreet systems cannot be sustained.

But this does not mean we can disregard the propaganda initiatives derived from Kahneman and Tverskys work. Many of the persuasive techniques being employed in these efforts have been known intuitively for centuries. They have been used by governments, religions, and the arts.14 Now, however, these techniques are being extensively tested and combined with sophisticated data analysis. The two-systems view has managed to lend the appearance of legitimacy to techniques that might otherwise appear coercive. Experts, algorithms, and nudges may be presented as a form of collective rationality, assisted institutionally by markets and governments, stealthily undoing the knots of irrationality in which individuals have inevitably entangled themselves.

On this model, it appears that System Two, implemented from above, can liberate us from the flaws of System One. If we reject the distinction between these two supposedly separate psychological systems and instead pay attention to what can and cannot be rationally justified, it will be more evident that behavioral change imposed on us through nonrational means not only is more coercive than that which comes about through the rational evaluation of justifications, but also erodes our capacity to reflect rationally and critically on our social world. The sources of influence that shape social behavior, markets, and politics increasingly become invisible and rationally inscrutable.

Comparatively little attention has been paid to overcoming the biases that psychologists have identified, except insofar as this might serve the national security objective of discouraging extremism through the introduction of measures to combat effects such as confirmation bias.15 It is still possible to envisage behavioral science playing a part in the great social experiment of providing the kind of public education that nurtures the critical faculties of everyone in our society. But the pressures to exploit irrationalities rather than eliminate them are great and the chaos caused by competition to exploit them is perhaps already too intractable for us to rein in. In The Undoing Project, Lewis tells a story full of promise about the unraveling of obsolete assumptions. But Kahneman and Tverskys ideas have escaped the confines of their troubled friendship and we have yet to see how much will be undone.

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Invisible Manipulators of Your Mind | by Tamsin Shaw | The New ... - The New York Review of Books

BRIEF-Cancer Genetics and Mendel.ai announce strategic partnership – Reuters

BRIEF-Casella Waste says invited prospective lenders for considering potential repricing of term loan B facility of $350 million

* Casella Waste says invited prospective lenders to meeting scheduled for April 3 for considering potential repricing of term loan B facility of $350 million Source text for Eikon: Further company coverage:

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BRIEF-Cancer Genetics and Mendel.ai announce strategic partnership - Reuters

Your Cheat-Sheet Guide to Synthetic Biology – Slate Magazine

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Drew Endy: Endy, a Stanford biotechnologist who focuses on genetic computing, has helped drive efforts to keep synthetic biology open source.

Jay Keasling: A chemical- and bioengineer based at University of CaliforniaBerkeley, Keasling led an effort to synthetically produce aremisinin, a powerful anti-malarial drug.

Kristala Prather: Prather, an MIT professor, runs a lab working to turn microbes into chemical factories.

J. Craig Venter: After playing an important role in early efforts to sequence the human genome, Venter now heads the J. Craig Venter Institute, whose work involves, among other things, research on synthetic life forms.

Christopher Voigt: Voigt is an MIT biological engineer who has worked at the intersection of synthetic biology and CRSIPR gene editing technology.

Boundaries of species: Synthetic biologists sometimes take genetic material from one species and implant it in another. Will such transplantations challenge our ability to make sense of the unnatural world? Is it ethical to fuse organisms that would otherwise remain distinct?

Computational comparisons: Proponents of synthetic biology often suggest that we should be able to encode genetic material in much the same way that we program computers, but real lab work doesnt always bear that metaphor out. Will synthetic biology advance to the point where this comparison works in practice?

Ecological implications: Some critics of synthetic biology worry about what will happen when lab-made organisms start finding their way into the wild. Will these synthetic creations destroy already fragile ecosystems? Or will this simply be the next step in our species long-running agricultural transformation of the world?

Eugenics: As synthetic biology advances, we may gain the ability to introduce novel sequences into the human genome, allowing us to reconfigure our own offspring. What are the ethical implications of taking evolution into our own hands?

Regulatory uncertainty: At present, there are few to no legal standards specific to the practice of synthetic biology. Are we courting environmental or medical disaster in the absence of such norms? If we did impose laws, would we risk dramatically impeding the pace of progress?

BioBricks: DNA strings designed to be pieced together in synthetic biology applications.

Biofuel: A fuel generated from a living organisma primary goal for many synthetic biologists.

Carson curve: An analogue to Moores law, the Carlson curve describes the rate at which our ability to synthesize DNA is accelerating.

CRISPR: A genetic editing technique that involves copying and pasting strings of DNA.

Metabolic pathway: A sequence of chemical reactions that occur within a cell. Some synthetic biologists seek to manipulate these pathways in laboratory organisms to produce novel outputs.

Synthetic biology: An interdisciplinary research field that combines the insights of computer science, engineering, genetics, and cellular biology in an effort to reshape the building blocks of life.

A Life of Its Own by Michael Specter: In this long New Yorker article, Specter discusses some of synthetic biologys most prominent achievements.

Our Biotech Future by Freeman Dyson: In this seminal 2007 New York Review of Books essay, physicist Dyson argued that green technology could radically upset the balance of power in the world.

The Principles for the Oversight of Synthetic Biology: This collaboratively drafted document suggests a set of industrial and experimental oversight mechanisms that would be specific to the challenges of synthetic biology.

Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves by George M. Church and Ed Regis: This recent book looks at the practical promise of biotechnology as we continue to transform the microbial world.

Synthetic: How Life Got Made by Sophia Roosth: In this book, Roosth, a cultural anthropologist, discusses her study of synthetic biologists, revealing how they understand the world that they are shaping.

Why Kickstarters Glowing Plant Left Backers in the Dark by Antonio Regaldo: Revisiting the largely failed Glowing Plants project, Regaldo looks into the practical limitations of synthetic biology.

BioShock, directed by Ken Levine: This video game takes place in an underwater city whose residents modify their DNA to provide themselves with superhuman abilities.

Blood Music by Greg Bear: In this novel, biological computers infect humans, reshaping their lives and their world in the process.

Change Agent by Daniel Suarez: In the near-future world of this novel, an Interpol agent tries to fight back against a powerful biocrime syndicate after it rewrites his own genome.

Gattaca, directed by Andrew Niccol: This film plays out in a world shaped by genetic analysis and eugenics.

Orphan Black, created by Graeme Manson and John Fawcett: A powerful biotech company manipulates the lives of a group of clones in this British television series.

This article is part of the synthetic biology installment of Futurography, a series in which Future Tense introduces readers to the technologies that will define tomorrow. Each month, well choose a new technology and break it down. Future Tense is a collaboration among Arizona State University, New America, and Slate.

Photo of Drew Endy, Jay Keasling, J. Craig Venter, and Christopher Voigt by Creative Commons. Photo of Kristala Prather by MIT.

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Your Cheat-Sheet Guide to Synthetic Biology - Slate Magazine

Young scientist wins gold awards – Worthing Herald

10:23 Monday 03 April 2017

Our Lady of Sion School student Blaise Cloran was the only national finalist from Sussex at the The Big Bang Fair 2017.

Blaise, from year nine, was also the only Sussex student to achieve a weeks stay to study biochemistry at Oxford this summer and a NASA science camp in America for five days in the summer holidays.

Helen Davis, assistant head (academic), said: She did not win one of the major prizes but she did get a gold medal and a gold crest award. These are a fantastic achievement for a 13-year-old.

All of these events have been supported by the school but she has earned her place through merit alone. They are not places gained by a paid-for-place in any of these examples.

Blaise has achieved all this through her own determination her parents are not scientists. She is a fantastic role model for girls in science, something the nation sadly lacks.

Blaise said being selected for The Big Bang Fair at Birmingham NEC and representing Our Lady of Sion School was a truly amazing experience.

I showcased and competed with my project, A Quicker More Efficient Method of Diagnosis for Hepatitis. My project used an ELISA test combined with silk fibroin to create a cheap, under-two-hour diagnosis method that can be transported without refrigeration. It uses hepatitis to demonstrate how the process works but it could be applied to any disease.

I went up to the NEC at Birmingham and stayed for four days. On the first day, all 600 finalists went to a welcome ceremony, where we listened to talks from well-known scientists, such as Greg Foot, and were given information about the next few days. It was quite nerve-racking to be the only student from the whole of Sussex but the familiar scientific environment engrossed me and I soon felt at home.

On the Wednesday, the show was opened to the public and my day consisted of lots of judging. Judges would come round in groups of two or four and would listen and examine my project, which was displayed on a stand. I really enjoyed talking to people who were interested in my project and the questioning members of the public were good practice before I talked to the judges.

There were also many other stands at the fair such as JCB, SeaWorld, Airbus, Rolls Royce, many universities and, of course, other competitors. I learned lots from looking round and talking to those who occupied stands. Shows and experiments would go all day, which added to the all excitement.

The next day, the award ceremony was held and I was lucky enough to win a medal and a gold crest award. I felt honoured and I know I will definitely be trying to attend next year.

Later this summer, I will be attending an Oxbridge course in biochemistry that I had to pass a round of Skype interviews to gain a place at, followed by a NASA camp in America. I was lucky enough to get into both of these and cant wait to attend them.

I was interviewed for the Oxbridge course and got confirmed a place to study biochemistry at Oxford for a week. I am extremely excited to see what life is like at the university and experience studying at a higher level.

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Southern Illinois University Edwardsville alumni make advancements – Alton Telegraph

EDWARDSVILLE The Southern Illinois University Edwardsville School of Education, Health and Human Behavior (SEHHB) is celebrating the continued professional achievements and proven leadership abilities of four alumni.

Edwardsville Community Unit District 7 Superintendent Lynda Andre has announced changes in leadership positions, including transitions to assistant principal and principal positions which involve SIUE alumni Tanya Patton, Andrew Gipson, Vince Schlueter and Julie Matarelli.

We are extremely proud of the many achievements and career advancements of our alumni, said Curt Lox, dean of the SEHHB. As educators and now administrators, these alumni are making a positive impact on the development of students across District 7. The School of Education, Health and Human Behavior has a rich history of preparing teachers and administrators, and it is great to see our community partners choosing our graduates to lead their schools.

Patton was named principal of Cassens Elementary School. She previously served as principal at Nelson Elementary School since 2005. Patton earned a masters in education administration in 2003, an education specialist degree in 2011 and a doctorate in educational leadership in 2014, all from SIUE.

Gipson, who earned a bachelors in music/music education from the SIUE College of Arts and Sciences in 2004, was named principal of Nelson Elementary School to replace Patton.

Schlueter was appointed assistant principal at Edwardsville High School. He has earned multiple degrees from SIUE including a bachelors in math studies in 1989, a masters in education administration in 2005, an education specialist degree in 2014, and a doctorate in educational leadership in 2016.

Matarelli earned a masters in education administration from SIUE in 2007. She was named principal at Columbus Elementary School.

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Southern Illinois University Edwardsville alumni make advancements - Alton Telegraph