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Proper funding for women’s health research could save lives during pandemic – Policy Options

Womens health research is chronically underfunded, and womens health receives little attention across the spectrum of health research, from funding to academic opportunities. Although steps have been taken to incorporate sex and gender-based analysis (SGBA) into research in Canada, there is a continued lack of analyses of sex and gender across health research areas. This lack of attention paid to SGBA and to womens health research has led to misdiagnoses, minimized symptoms and poorly targeted treatment in women.

Indeed, if we had provided more funding and resources to womens health research, one could make the argument that we would be closer in our search for a treatment and cure for COVID-19. Why?

Mortality from COVID-19 follows from attacks on the immune and vascular system, and both systems have striking sex differences. Yet, there is little research on how female-specific factors affect immune and vascular systems. If we knew more about how these systems work in women, we would be in a better position to understand why female physiology offers some protection against COVID-19-related mortality as shown in higher mortality rates in males. We would also be further ahead in our quest for an effective COVID-19 treatment for both men and women.

A sex and gender-focused approach and targeted consideration of womens health issues in health science research, policy and practice will ensure we do not deepen sex and gender disparities in COVID-19 research and outcomes and promote an inclusive and balanced path for the future health of all Canadians. And it will save lives, faster.

Sex differences matter in health research

Womens health research may seem like a niche research area; however, many diseases disproportionately affect women compared to men. For instance: depression and anxiety-related diseases are more prevalent in women than in men; heart attack symptoms manifest differently between the sexes; and treatments for certain diseases are more effective in one sex versus the other.

It is essential to understand these sex differences and how female-specific factors, such as contraceptive use, pregnancy and menopause, may contribute to disease susceptibility, symptoms and treatment. These unique aspects of womens health are compounded by a range of intersectional factors such as gendered societal norms, race and socioeconomic status, which can accumulate to negatively affect womens health, and are often ignored in health literature.

Womens health research is chronically underfunded. In a 2019 report commissioned by B.C. Womens Health Foundation, we found that over the past ten years, one percent of salary awards went to womens health researchers in Canada, and in B.C., womens health grants made up only eight percent of Canadian Institutes for Health Research (CIHR) grants. Given that women make up over 50 percent of the population, these percentages are dishearteningly low.

Furthermore, the amount of funding per grant was $50,000 lower per year for womens health grants compared to others. Perhaps unsurprisingly, more women than men researchers study womens health and conduct research analysing sex and gender. Women, on average, have lower funding success rates at CIHR, and receive less money (over $100,000 less per CIHR grant).

Inequities exacerbated by COVID-19

COVID-19 has amplified these inequities in womens health research affecting funding, authorship, data acquisition and analysis. Health research suffered a serious blow when CIHR cancelled their 2020 spring competition one month after grants were submitted. Thankfully, the decision was reversed; however, the subsequent delay and resulting interim funding gap will have a cascading negative impact on health researchers, disproportionately affecting those with less funding, including womens health researchers. Unpredictability of funding opportunities and low funding levels greatly impede research progress according to a survey of Canadian health researchers.

Emerging data indicates that women researchers are being surpassed by their male counterparts in COVID-19 scientific outputs, likely linked to the increased volume of caregiving and domestic responsibilities falling on women during the pandemic. Females are conducting less research on COVID-19, as depicted by publications, registered reports and awarded grants.

Furthermore, fewer female researchers as first authors are submitting and publishing during the pandemic compared to the year prior and these trends appear to be getting worse as time goes on. From the CIHR funding decisions database, of the initial 99 grants awarded for the CIHR Novel Coronavirus (COVID-19) Rapid Research Funding Opportunity, only 23 percent of the grant awardees had a woman as the nominated principal investigator.

In the latest round of CIHR COVID-19 grants, which included grants on mental health, clinical management and social policy, the percentage of grants lead by a woman as principal investigator increased to 40 percent.

Yet the general picture is still worrying. Studies indicate that diversity breeds discovery. We need more minds with diverse interests and multidisciplinary research to solve the many health, economic and societal issues related to the pandemic. If women are missing from the equation, diversity is compromised, and we will continue to lag in our efforts to solve the pandemic crisis for all.

Worse yet, commitment to SGBA for COVID-19 research grants is not evident. Only four percent of awarded grants met SGBA criteria, and only two percent went specifically to studying womens health. Two months after the funding announcements, a supplement to understand the effect of sex as a biological variable (SABV) was awarded and currently 11 percent of the COVID-19 grants consider SGBA.

This is still not enough. If we ignore sex and gender as a variable in COVID-19 research, we miss crucial information to propel the research forward.

Disaggregated data is a critical tool

Additionally, despite the Canadian governments commitment to applying a GBA+ policy lens in its decisions, it is difficult to find Canadian data on COVID-19 infections, hospitalizations and deaths disaggregated by sex and age.

Canada is one of the countries now providing the Global Health 50/50 program with sex-disaggregated data. However, the troubling lack of commitment to SGBA in the CIHR COVID-19 funding decisions, makes it evident that little work in Canada is underway to investigate the known sex and gender differences of this disease.

To rectify these biases and inequities, first and foremost, funding for womens health research needs to increase by creating dedicated funding sources specifically for womens health research, both for COVID-19 and for womens health research in general.

Second, Canada needs to create a national open repository where all federally funded research must be submitted with mandatory recording of sex, gender and age data. Doing so will enable secondary analyses of sex and gender and allow for new health initiatives that benefit women, men and gender diverse peoples.

Third, while federal funding agencies such as CIHR are to be applauded for making gender metrics public, granting bodies must consistently demonstrate a commitment to gender equity in funding awards, terms and amounts. One method is to employ modular budgets, which have eliminated sex differences in funding amounts for the National Institute of Health in the United States and reduced sex differences in funded grant amounts to less than $5000 under the Natural Sciences and Engineering Research Council of Canada system.

These steps will improve health research both in response to this pandemic and more widely. It will also help us better respond to future pandemics. The solution is simple: fund more womens health research.

This article is part of theTackling inequality as part of Canadas post-pandemic recoveryspecial feature.

Photo: Shutterstock/By Gorodenkoff

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Proper funding for women's health research could save lives during pandemic - Policy Options

Animal Model Market research gain impetus due to the growing demand over (2020 2027) – The Daily Chronicle

Global Animal model market report provides geographic analysis covering regions such as North America, Europe, Asia Pacific, and Rest of World. The Animal model market for each region is further segmented for major countries including U.S., Canada, Germany, UK, France, Italy, China, India, Japan, Brazil, South Africa and others.

FYI, You will get latest updated report as per the COVID-19 Impact on this industry. Our updated reports will now feature detailed analysis that will help you make critical decisions.

Browse Full Report: https://www.marketresearchengine.com/animal-model-market

The Global Animal Model market is expected to grow at a CAGR of 8% during the forecast period. Scientist and research professionals perform biological and pathological experiments on animals, which is called animal model as animals and human beings share common biological structure. The model is chosen usually because it meets the determined taxonomic equivalency to a human for the research and investigation purpose so as to get the better understanding of the human disease.

The growing innovation in genetic engineering that helps in evaluating the drugs mechanisms of action is again boosting the demand for the drug discovery thereby raising the demand for the animal model.

Global Animal model market is segregated on the basis of application as toxicology, biomedical research, physiology, cancer research, genetic research, neurological research, xenotransplantation. Based on animal type, the global Animal model market is segmented in rabbits, dogs, cats, rats, mice and others. The report also bifurcates global Animal model market based on end user in research institutes, pharmaceutical companies, and educational institutes.

Competitive Rivalry

Envigo, SAGE Labs, Transgenic, Inc. are among the major players in the global Animal model market share. The companies are involved in several growth and expansion strategies to gain a competitive advantage. Industry participants also follow value chain integration with business operations in multiple stages of the value chain.

The Animal Model Market has been segmented as below:

Animal Model Market, by Application

Animal Model Market, by Animal Type

Animal Model Market, by End User

Animal Model Market, By Region

The report covers:

Report scope:

Global Animal model market report scope includes detailed study covering underlying factors influencing the industry trends.

The report covers analysis on regional and country level market dynamics. The scope also covers competitive overview providing company market shares along with company profiles for major revenue contributing companies.

The report scope includes detailed competitive outlook covering market shares and profiles key participants in the global Animal model market share. Major industry players with significant revenue share include SAGE Labs, Envigo, Transgenic, Inc., Charles River Laboratories etc.

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Animal Model Market research gain impetus due to the growing demand over (2020 2027) - The Daily Chronicle

ONLINE: The Future of Medicine – Isthmus

Watch here: https://www.youtube.com/watch?feature=youtu.be&v=VVkQU91KbEs

press release: The UW has a long history of pioneering medical advancements that have transformed the world. From performing the first bone marrow transplant in the United States to cultivating the first laboratory-derived human embryonic stem cells. Now, where will UW medical research go next?

On the next Wisconsin Medicine Livestream, meet trailblazing doctors, researchers, and medical leaders who are charting a bold course to completely alter the health care landscape. During this insightful panel discussion, well explore how gene therapy and cell replacements could hold the keys to treating inherited and acquired blindness. Youll also discover the remarkable potential in xenotransplantation where nonhuman animal source organs are transplanted into human recipients. In addition, you will learn about UW Healths journey to build a multidisciplinary program to serve the community. These, and other, fascinating developments in treatment and care are happening right now at the UW and are the future of medicine. The presentation will be moderated by Robert Golden, the dean of the University of WisconsinMadisons School of Medicine and Public Health.

Our Guests:

David Gamm, professor, Department of Ophthalmology and Visual Sciences; Emmett A. Humble Distinguished Director, McPherson Eye Research Institute; Sandra Lemke Trout Chair in Eye Research

Dr. Gamms lab is at the forefront in developing cell-based therapies to combat retinal degenerative diseases (RDDs). As the director of the McPherson Eye Research Institute and a member of the Waisman Center Stem Cell Research Program, the UW Stem Cell and Regenerative Medicine Center, and the American Society for Clinical Investigation, his efforts are directed toward basic and translational retinal stem cell research. The Gamm Lab uses induced pluripotent stem cells to create retinal tissues composed of authentic human photoreceptor cells rods and cones that can detect light and initiate visual signals in a dish. The aims of his laboratory are to investigate the cellular and molecular events that occur during human retinal development and to generate cells for use in retinal disease modeling and cell replacement therapies. In collaboration with other researchers at UWMadison and around the world, the lab is developing methods to produce and transplant photoreceptors and/or retinal pigment epithelium (RPE) in preparation for future clinical trials. At the same time, the Gamm Lab uses lab-grown photoreceptor and RPE cells to test and advance a host of other experimental treatments, including gene therapies. In so doing, the lab seeks to delay or reverse the effects of blinding disorders, such as retinitis pigmentosa and age-related macular degeneration, and to develop or codevelop effective interventions for these RDDs at all stages of disease.

Dhanansayan Shanmuganayagam, assistant professor, Department of Surgery, School of Medicine and Public Health; Department of Animal and Dairy Sciences, UWMadison; director, Biomedical, and Genomic Research Group

Dr. Shanmuganayagams research focuses on the development and utilization of pigs as homologous models to close the translational gap in human disease research, taking advantage of the overwhelming similarities between pigs and humans in terms of genetics, anatomy, physiology, and immunology. He and his colleagues created the human-sized Wisconsin Miniature Swine breed that is unique to the university. The breed exhibits greater physiological similarity to humans, particularly in vascular biology and in modeling metabolic disorders and obesity. He currently leads genetic engineering of swine at the UW. His team has created more than 15 genetic porcine models including several of pediatric genetic cancer-predisposition disorders such as neurofibromatosis type 1 (NF1). In the context of NF1, his lab is studying the role of alternative splicing of the nf1 gene on the tissue-specific function of neurofibromin and whether gene therapy to modulate the regulation of this splicing can be used as a viable treatment strategy for children with the disorder.

Dr. Shanmuganayagam is also currently leading the efforts to establish the University of Wisconsin Center for Biomedical Swine Research and Innovation (CBSRI) that will leverage the translatability of research in pig models and UWMadisons unique swine and biomedical research infrastructure, resources, and expertise to conduct innovative basic and translational research on human diseases. The central mission of CBSRI is to innovate and accelerate the discovery and development of clinically relevant therapies and technologies. The center will also serve to innovate graduate and medical training. As the only center of its kind in the United States, CBSRI will make UWMadison a hub of translational research and industry-partnered biomedical innovation.

Petros Anagnostopoulos, surgeon in chief, American Family Childrens Hospital; chief, Section of Pediatric Cardiothoracic Surgery; professor, Department of Surgery, Division of Cardiothoracic Surgery

Dr. Anagnostopoulos is certified by the American Board of Thoracic Surgery and the American Board of Surgery. He completed two fellowships, one in cardiothoracic surgery at the University of Pittsburgh School of Medicine and a second in pediatric cardiac surgery at the University of California, San Francisco School of Medicine. He completed his general surgery residency at Henry Ford Hospital in Detroit. Dr. Anagnostopoulos received his MD from the University of Athens Medical School, Greece. His clinical interests include pediatric congenital heart surgery and minimally invasive heart surgery.

Dr. Anagnostopoulos specializes in complex neonatal and infant cardiac reconstructive surgery, pediatric heart surgery, adult congenital cardiac surgery, single ventricle palliation, extracorporeal life support, extracorporeal membrane oxygenation, ventricular assist devices, minimally invasive cardiac surgery, hybrid surgical-catheterization cardiac surgery, off-pump cardiac surgery, complex mitral and tricuspid valve repair, aortic root surgery, tetralogy of Fallot, coronary artery anomalies, Ross operations, obstructive cardiomyopathy, and heart transplantation.

When: Tuesday, Sept. 29, at 7 p.m. CDT

Where: Wisconsin Medicine Livestream: wiscmedicine.org/programs/ending-alzheimers

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ONLINE: The Future of Medicine - Isthmus

Schools rise to face crisis, changing the face of education – Terre Haute Tribune Star

A year ago, no one could have anticipated a pandemic that would force colleges to send students home early and finish the academic year through online, remote education.

The past several months have been a time of great uncertainty for higher education, both in terms of enrollment and revenue. And while the challenges have been many, Terre Hautes four colleges and universities have risen to the occasion and made changes that will benefit them, and students, moving forward.

Tribune-Star/Joseph C. GarzaTaking care of those on Zoom: Indiana State University student Hannah DeBlock serves as a teaching assistant and works with the Zoom students, answering or forwarding their questions or monitoring their answers delivered via chat to multiple choice questions during assistant professor Jim Davis' human physiology class on Sept. 3 on the ISU campus.

Under the guise of never waste a good crisis, I think we have learned some things as a part of the pandemic, said Rob Coons, president of Rose-Hulman Institute of Technology. It required us to do some things online or think about the way we present things differently than we might otherwise have chosen to do.

Coons adds, I think thats been good. Thats had some advantages.

Indiana State University

In a lecture hall of Indiana State Universitys College of Health and Human Services, assistant professor Jim Davis taught his Human Physiology hybrid class not only to the 70 or so students there in person, but others attending online via Zoom. Part of the lesson dealt with reflexes and their role in nervous system function.

Periodically, he had to adjust cameras so the distance students could see what he had written on a board. One student watching via Zoom asked for a camera adjustment so they could better see Davis nonverbal language.

Nearby, student Hannah DeBlock served as a teaching assistant and worked with the Zoom students, answering or forwarding their questions or monitoring their answers delivered via chat to multiple choice questions.

The challenges are many, but the benefits are that students who arent in class for whatever reason can still participate, Davis said.

While it isnt my ideal method of teaching, I do think that I will always use Zoom in the future so that students who are sick, out of town, etc. have the ability to participate in a live lecture.

Among the challenges are small group discussion involving Zoom students. Also, with masking, I cant tell what my students are thinking, and I am struggling to learn student names which I believe makes it more difficult to foster that student-teacher relationship that is important for learning.

He has eliminated small group activities, which he said is unfortunate because it often brings on those light bulb moments.

Hes gone the extra mile to help students learn when they cant be in class. Over the summer, he created a series of 100 mini lectures that cover all of the material for the semester. That way if someone misses a lecture or doesnt understand a specific concept they can go to a video that just focuses on that one concept, he said.

Davis is one of many ISU faculty members working to provide a quality education to students in class, and those who may be out for various reasons that might include isolation or quarantine because of COVID.

Many ISU faculty have spent part of the summer planning for and redesigning courses to meet changes required because of the pandemic, said Molly Hare, director of the Faculty Center for Teaching Excellence.

They may maybe teaching a face-to-face class, but at the same time, they may also be teaching students online, real-time, via Zoom. And, they may have to tape the class for those who cant attend in-person or watch in real time.

Students who are in class one day may have to attend via Zoom another day because they are isolated with COVID or on quarantine. That greatly affects the ability to carry out that class plan. Faculty have to be flexible, nimble and be able to adjust to meet the needs of students, Hare said.

Every time they go into a face-to-face classroom, it looks different, she said.

They have to have a Plan A, Plan B and Plan C. They are doing triple the work in order to offer students a quality education. And its very tiring, she said. Thats triple the work, times four classes they might be teaching.

She describes it as mental gymnastics.

And, they may face barriers, including technology glitches, they didnt anticipate, yet have to try and overcome, she said.

In addition, several courses are hybrid, with both in-person and online components for all students in the class.

Its challenging and a lot of work. But at the same time, Faculty really care about the quality of education and want students to get the outcomes they deserve, Hare said.

Hare works with faculty at the center. Typically, the center isnt as active over the summer, but this past summer, faculty took advantage of sessions offered each day. A lot of faculty have really worked hard, Hare said.

Students are stressed as well, she said. Every class is different, and if the class is hybrid, students must pay attention to whether that day is in-person or via Zoom and how assignments should be submitted.

Among the benefits of pandemic-related changes are more electronic submissions and less paper.

Instruction techniques are changing for some classes. For example, a student may watch a prerecorded lesson on line, and then do the hands-on portion, or homework, in class, where they can get faculty assistance if needed. Its called a flipped classroom.

The center does individual consultations or meets with groups for a particular reason; it offers professional development. Our motto is inform, innovate and celebrate teaching, she said. We look at how to do things a new

Tribune-Star file/Joseph C. GarzaBless this ground: Sister Dawn Tomaszewski blesses the ground on which a new residence hall will be built before a groundbreaking ceremony Thursday, June 18, on the campus of Saint Mary-of-the-Woods College.

The Woods

Despite the many uncertainties created by the pandemic, Dottie King, president of Saint Mary-of-the-Woods College, believed the Woods still needed to keep making forward progress.

We thought, how can we even in the midst of these times continue to not just get through, but really make some significant strides with our progress, she said.

In spring, admissions staff came up with some innovative ways to reach students, including a virtual, live-streamed campus visit with about 300 students and parents logged in and watching.

We didnt get as big a class as we had planned on, but we still saw a modest increase from last year for the on campus program, King said. The freshman class increased about 11 percent. Total enrollment including on campus, graduate and online programs is about 1,075.

SMWC also plans to add programs, hopefully with funding through the Lilly Endowment. It plans to offer a doctoral program its first in global leadership. Given the pandemic, which affects countries across the globe, King considers it providential the college was considering such a program even prior to the pandemic.

COVID-19 has affirmed the need for such a program, in which people across the globe would work together to find solutions, rather than relying solely on government, she said.

The college also plans to offer a bachelors in exercise science, a continuation of its focus on health care. The college already has programs in nursing, kinesiology and health care administration.

The new programs will go forward with or without Lilly funding, but those funds would enable the college to proceed more quickly, King said.

The college also is building its first new residence hall since 1924. Currently, LeFer residence hall is approaching capacity. We have more graduate students inquiring about being residential. Right now we dont have that opportunity, King said.

The new residence hall will increase capacity for undergraduates, and also add the ability for graduate students to live on campus, she said.

The college also is offering graduate assistantships for the first time, King said.

Sarah DeWeese/Ivy Tech-Terre HauteChris Gresham, Ivy Tech-Terre Haute criminal justice instructor, teaches Introduction to Criminology in a Learn Anywhere class.

Ivy Tech Community College Terre Haute

Imagine a college class where you attend in person if you are able.

But if child care or work issues or even COVID-19 quarantine prevents you from going to class, you can attend online, real-time or watch a video of the class when you are able.

Ivy Tech is piloting some classes using this format, which is called Learn Anywhere.

The initiative grew out of a grant our Indianapolis campus and Muncie campus had on addressing challenges that single-mother students encounter, said Lea Anne Crooks, chancellor at Ivy Tech-Terre Haute.

With Learn Anywhere, instructors deliver class face-to-face with any student who can get there, but for those who cant attend in person, students can participate real time through Zoom. Also, the class is taped so a student who couldnt do either that day can watch it when they do have time.

We are being as flexible as we can for students, Crooks said. One week, a student may attend in person, another week, they may attend online. It also helps those students who may have to quarantine or isolate because of COVID-19.

The program is being piloted statewide, with four classes [six sections] being offered as Learn Anytime at Ivy Tech-Terre Haute. They are: intro to criminology; informatics fundamentals; fundamentals of public speaking and introduction to interpersonal communication.

We think this is something that will continue to grow and be really a great option for students in the future, Crooks said.

Teaching in the various Learn Anywhere formats has its challenges, so I really applaud our faculty who have stepped up and are looking at this as a way to assist our students, she said.

In another change this fall, courses that require hands-on learning are taking place face-to-face and on campus, including programs in health sciences, nursing, information technology, advanced manufacturing and engineering/applied science.

Most general education, business and liberal arts courses are offered virtually or online only; virtual courses are live, via Zoom, allowing for interaction. Online classes are not real-time and can be done as the students schedule allows.

Online courses allow students more flexibility and allow them to complete their coursework at days/times that are convenient for them. They still must complete assignments by their deadlines, but they do not have to attend class at a specific time. Instructors require participation through discussion boards and not live video.

The number of students on campus is about half of what it would be in a normal year, Crooks said. I wish we had the energy of what the campus normally feels like, but its where it should be because of the pandemic.

These are challenging times for our instructors, she said. But faculty and staff have stepped up to meet students needs and faculty are going the extra mile.

Students are still able to enroll for 8-week classes that begin in October. With the uncertainties of COVID, many have delayed enrolling, including parents who may not have known childrens school schedules, or high school graduates thinking theyll wait a year to start college.

Its not the time to take a break, Crooks said.

If students are choosing a gap year because they intend to go to a four-year university next year, We encourage them to consider staying in the academic mode and taking courses this year from Ivy Tech, which they will be able to transfer, she said.

Rose-Hulman Institute of Technology

At Rose-Hulman, a team of faculty have been gathering from colleagues ways theyve used online technology or other creative means to share concepts with students, when in-person classes were not possible, said college president Rob Coons.

The goal is to determine whether some of those tools or course delivery strategies can be used to improve classroom instruction overall and make it more efficient, potentially saving students money.

For example, for chemistry experiments and lab work in some of the other engineering disciplines, faculty assembled kits and mailed them home to students this past spring. Students did part of the experiments or labs while at home, and then demonstrated their lab results in a variety of different ways depending on the class.

For example, in some cases the professor had students demonstrate their work during a video call. In other cases, the professor would have the them submit laboratory reports.

It might seem more cumbersome, yet, Some of our faculty are still studying it, but they feel some of that learning that occurred because students had to make that adaptation was really positive, Coons said.

As a result, the college is starting to look for ways we can incorporate the good things we learned as part of the pandemic back into the classroom, so that ultimately, regardless of method of delivery, it is an outstanding educational experience, Coons said.

There are elements of the education experience best presented in person and there are also many that can be presented just as well online, he said. We are learning from that process and trying to take the best of those things moving forward.

A number of courses this fall are blended, with part of the course online and part in person, he said. Originally, it was being done to reduce the amount of risk and exposure of employees and students to the COVID virus.

The college is still gathering data, but, We think there are ways to improve the efficiency of the class and begin to look at ways in which we could either perhaps, shorten the schedule or adjust the schedule in some way which in turn can convert to actual savings for the student. I think there is some opportunity there, Coons said.

Sue Loughlin can be reached at 812-231-4235 or at sue.loughlin@tribstar.com Follow Sue on Twitter @TribStarSue.

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Schools rise to face crisis, changing the face of education - Terre Haute Tribune Star

Study shows clear links between genetic predisposition of CVD and lifestyle factors – News-Medical.Net

Reviewed by Emily Henderson, B.Sc.Sep 28 2020

From Weight Watchers to wearable tech wherever we look, there are messages encouraging us to stay fit and healthy.

But diets and training methods aside, when it comes to heart health, research from the University of South Australia shows that a far more personalized approach is neededand it all starts with your genes.

Conducted in partnership with the University of New England and the University of Queensland, the study assessed the impact of lifestyle factors on cardiovascular disease (CVD), finding clear links between genetic predisposition of CVD and smoking, alcohol intake, physical activity and diet.

UniSA researcher, Associate Professor Hong Lee, leader of the statistical genetics group at the Australian Centre for Precision Health, says the popular 'one-size-fits-all' approach to heart health does not have uniform effects, and that a tailored, individualised approach to CVD is essential.

Globally, CVD is the number one cause of death, claiming an estimated 17.9 million lives a year. Most deaths are due to heart attacks and strokes, with a third of these occurring prematurely in people under 70 years of age. In Australia, heart disease kills one Australian every four minutes.

"Every day, we're exposed to information that promotes positive lifestyle factors for better health. But what we don't hear, is how individual genetic differences can negate positive effects, often to detriment of the individual," Assoc Prof Lee says.

"Between 20 to 60 percent of risk factors for CVD are attributed to genetics which are far better addressed through personalised and individual interventions than broad-stroke lifestyle adjustments.

"For example, genetics show how the level of your cholesterol can be controlled by a lifestyle modification, given your genotypes and the underlying genetic link between cholesterol and lifestyle factors.

"This will help you make a decision about which lifestyle intervention is most suitable for you, for example, more exercise might be a better choice than reducing smoking.

"However, this does not necessary mean that exercise is uniformly recommended for other people who may have different genes and genetic effects that are more sensitive to smoking exposure.

"It's all about understanding how individual genetic risks can change in line with different lifestyle adjustments, and consequently how cardiovascular health can benefit."

Using a novel whole-genome approach, researchers analyzed 23 cardiovascular health-related traits and 22 lifestyle characteristics using the ARIC (Atherosclerosis Risk in Communities) Study (N=8291) and validating results via the UK Biobank (N~500,000). 34 significant CVD trait-lifestyle pairs were identified.

While Assoc Prof Lee agrees that positive lifestyle changes are good for overall health, including cardiovascular health, he says tailored interventions based on individual differences will be most successful for managing CVD.

As precision health practices advance, we are likely to see more personalised health treatments that are based on individual genetic profiles."

Hong Lee, Researcher and Associate Professor, University of South Australia

"We are currently in the process of developing tools that can predict genetic risk based on genotypes and how lifestyle changes can modulate these.

"Incorporating individual (genetic) differences into CVD interventions will absolutely increase the predictive power of lifestyle changes on individual health."

Source:

Journal reference:

Zhou, X., et al. (2020) WholeGenome Approach Discovers Novel Genetic and Nongenetic Variance Components Modulated by Lifestyle for Cardiovascular Health. Journal of the American Heart Association. doi.org/10.1161/JAHA.119.015661.

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Study shows clear links between genetic predisposition of CVD and lifestyle factors - News-Medical.Net

Study into left-handedness finds 41 genetic variants that influence it – ABC News

About 10 per cent of Australians are left-handed and genetic analysis of more than 1.7 million people has brought scientists a step closer to understanding why.

Researchers from QIMR Berghofer Medical Research Institute and the University of Queensland have identified 48 genetic variants that influence if a person is left-handed, right-handed or ambidextrous.

Forty-one variants were linked to left-handedness and seven were associated with ambidexterity.

"Handedness is one of those things where both genetics and environment play a large role and what we've been able to do is advance the knowledge quite a bit further in the genetics side," Professor Sarah Medland from QIMR Berghofer's Psychiatric Genetics Group said.

"Each of these [variants] are just little changes in the DNA each of them individually have very, very small effects but when you consider all the effects together, they start to add up."

Researchers tapped into international biobanks to analyse genetic data from more than 1.7 million samples, making it one of the largest investigations of its kind.

The findings were published in the journal Nature Human Behaviour.

Professor Medland said environmental factors play a larger role than genes in determining which hand a person favours.

"Something like height is much more strongly genetically-influenced, whereas [for] something like handedness the genetic influences are relatively weak," she said.

"Through training or just through interacting with the environment and using tools that are designed one way or the other, you can actually influence someone's handedness quite a lot."

Professor Medland said the research also dispelled the belief that ambidextrousness was a middle-zone between left and right-handedness.

"The results from our study shows there was not very much genetic overlap actually between left-handedness and ambidextrousness it seems like there are different mechanisms going on there," she said.

She said more research was needed to help answer why people developed a dominant hand.

"The reason why we do this work is to help us understand ourselves as humans and this characteristic of ourselves," Professor Medland said.

"Although we've found 41 variants influencing left-handedness and seven influencing ambidextrousness, there's a lot more out there to find."

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Study into left-handedness finds 41 genetic variants that influence it - ABC News

Applied Biology in Collaboration with Researchers at University Hospital Ramon y Cajal Hospital Announce Results from Study of Androgen Receptor…

IRVINE, Calif.--(BUSINESS WIRE)--Applied Biology in collaboration with researchers at University Hospital Ramon y Cajal in Madrid, Spain, today announced results from their androgen receptor genetics study in hospitalized COVID-19 male patients (NCT04368897, https://clinicaltrials.gov/ct2/show/NCT04368897?term=androgen&cond=Covid19&draw=2&rank=4). The aim of the study was to confirm a direct association between androgens and COVID-19, potentially paving the way for a breakthrough therapy against SARS-CoV-2.

This prospective longitudinal study analyzed the length of a variable genetic repeat in the androgen receptor gene of hospitalized COVID-19 male patients. The results of the clinical study were published in the Journal of the European Academy of Dermatology and Venerology (doi: 10.1111/jdv.16956).

The study demonstrated that the proportion of male patients admitted to the ICU with the longer variant was statistically significantly higher compared to males with the shorter variant. Similarly, the risk of ICU admissions was significantly higher among males with the longer variant (OR 2.9143). In addition, COVID-19 patients with the shorter variant experienced a shorter duration of hospitalization compared to males with the longer variant (25 days vs 47.5 days). Overall, the longer variant of the androgen receptor was associated with higher disease severity among hospitalized male COVID-19 patients.

The team was led by Andy Goren, MD, Medical Researcher and Co-Investigator with the Department of Dermatology at the University Hospital Ramon y Cajal in Madrid, Spain; Sergio Va Galvn, MD, from the Department of Dermatology at the University Hospital Ramon y Cajal; Sabina Herrera, MD, from the Infectious Disease Department at the University Hospital Ramon y Cajal; Carlos G. Wambier, MD, PhD, from the Department of Dermatology at the Alpert Medical School of Brown University; and Flavio A. Cadegiani, MD, MSc, PhD, from Corpometria Institute in Brazil.

According to Dr. Sergio Va Galvn: To the best of our knowledge, this is the first study to directly confirm an association between androgens and COVID-19 disease severity.

According to Dr. Carlos Wambier: This is another piece of the puzzle for the scientific understanding of role of androgens in the pandemic.

Further, according to Dr. Andy Goren: The results of this study further support our research into the use of anti-androgens in the treatment of COVID-19. If randomized prospective trials demonstrate efficacy, anti-androgens may provide a breakthrough inexpensive treatment for COVID-19.

ABOUT APPLIED BIOLOGY

Founded in 2002, Applied Biology, Inc. (www.appliedbiology.com), headquartered in Irvine, California, is a biotechnology company specializing in hair and skin science. Applied Biology develops breakthrough drugs and medical devices for the treatment of androgen mediated dermatological conditions. Applied Biology's R&D pipeline includes a topically applied prophylactic treatment for chemotherapy induced alopecia; a novel diagnostic device that can aid dermatologists in identifying non-responders to topical minoxidil; an adjuvant therapy for non-responders to topical minoxidil; and a novel therapy for female pattern hair loss.

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Applied Biology in Collaboration with Researchers at University Hospital Ramon y Cajal Hospital Announce Results from Study of Androgen Receptor...

Genetic testing helps patients be proactive in seeking healthcare – The Columbus Dispatch

Megan Henry|The Columbus Dispatch

Joan Swarts recently learned she has a greater risk of developing colon, ovarian and breast cancer.

Genetic testing counselors at OhioHealth were able to discover all of this information after taking ablood sample from her back in February.

Now, Swarts, 55, of Delaware,is being proactive. She recently met with a colorectal surgeon and knows to increase the frequency of her colon screenings.

Im glad that I now know thats a potential and I can take steps to watch for that to catch it early, she said.

Genetic testing recognizes changes in chromosomes, genes or proteins. The results can help confirm or dismiss a suspected genetic condition;help determine a persons chance of developing a genetic condition; and show the likelihood of passing on a genetic disorder, according to the National Library of Medicine.

What we hope is that the genetic testing information is going to give us a very personalized plan for what that person needs to do based on their genetic testing results and based on their family history, said Amy Sturm, a cardiovascular genetics expert for the National Society of Genetic Counselors.

Test results come back either positive (meaning the test found a genetic change known to cause disease),negative (meaning the test did not find a genetic change known to cause disease), oruncertain (meaning there isn't enough information about the genetic change to figure out if it's normal or could cause a disease), according to the Centers for Disease Control and Prevention.

The results can answer questions like, Are there things that I can do that will enable me to not develop this disease? Or that can basically modify my risk or things that I can do to prepare myself for what might come in the future because I have this genetic condition? said Nichole Morman, genetic counseling manageratOhioHealth.

The number of licensed genetic counselors in Ohio has been on the rise. There were 221 in 2016 and 423 in June of this year, according to the state medical board annual report.

People do genetic testing for a variety of reasons. Somemight wonder whether they are predisposed to a genetic condition if they have a family history. Or a person might want to know why they were diagnosed with a specific condition. They might also question whether they could pass on a genetic condition to a child.

Breast cancer runs in Swarts'family. Her grandmother died from breast cancer when she was 65, so Swarts'breast health doctor urged her to do genetic testing.

(The genetic testing)was really informative,"Swarts said."I felt like I was inundated with a lot of information but everything has been explained really well to me as far as preventive things I need to do.

Erin Pettegrew, 46, did genetic testing a couple of years ago after her mom was diagnosed with ovarian cancer seven years ago.

TheHilliard resident had the tests through the Making Genetic Testing Accessible (Magenta) study, an at-home screening for 19 genetic abnormalitieslaunched out of the University of Texas MD Anderson Cancer Center.

She saw an ad for Magenta pop up on her Facebook and sent in her cheek swab after getting the kit. She got her results back a few weeks later saying she didnt have a genetic predisposition to ovarian cancer.

My heart was pounding as I opened the email for sure, but once I saw that it was negative it was a big relief, Pettegrew said. If it had been positive, I would have had to make some choices about maybe having my ovaries removed early in life and other considerations about my own health, but I didnt have to go down that path."

There is a psychological aspect tofinding out whether you're predisposed to a genetic condition, Morman noted.

How is that going to make me feel about myself? How is it going to impact my relationships with my family members?" Morman said.

Swarts's mind is more at ease knowing she has the potential for these diseases and she takes comfort knowing it can be caught early.

"Honestly, Im one of those people who thought I really dont want to know so I was nervous about doing it, but Im glad I did so I can take the necessary measures to look for this stuff,"Swarts said.

Direct-to-consumertesting like 23andMe is also an option, but the results can be limited.

If you are interested in doing genetic testing because of a family health history of a certain disease, we do not recommend doing a 23andMe test, rather you should speak to your health-care provider,Aushawna Collins, 23andMe spokesperson, said in an email.

Genetic testing is continuing to evolve and whole-genome sequencing for newborns could be on the horizon.

A baby is born and you want to know for that baby's entire life what might they be at risk for, Sturm said. I think really getting that full genome sequencing at a very young age and then using it as a resource throughout their life is something we really are striving toward in our field.

mhenry@dispatch.com

@megankhenry

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Genetic testing helps patients be proactive in seeking healthcare - The Columbus Dispatch

COVID-19 Impact on Methylidenesuccinic Acid Market Top Manufacturers, Types and Application 2020| Kehai Biochemistry, Alpha Chemika, Guoguang…

Global Methylidenesuccinic Acid Industry Amid Global COVID-19 Crisis: Report Hive Viewpoint

Chicago, United States: Global Methylidenesuccinic Acid Market report offers a detailed Outlook and future prospects of the Industry. The Methylidenesuccinic Acid Market report includes various topics like market size & share, Product types, applications, key market drivers & restraints, challenges, growth opportunities, key players, competitive landscape.

The global Methylidenesuccinic Acid market is expected to reach xxx Million USD by 2025, with a CAGR of xx% from 2020 to 2025.

Top Players of Methylidenesuccinic Acid Market are Studied: Kehai Biochemistry, Alpha Chemika, Guoguang Biochemistry, Huaming Biochemistry, Zhongshun Science & Technology, ,

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The report incorporates significant sections, for example, type and end user and a variety of segments that decide the prospects of global Methylidenesuccinic Acid market. Each type provide data with respect to the business esteem during the conjecture time frame. The application area likewise gives information by volume and consumption during the estimate time frame. The comprehension of this segment direct the readers in perceiving the significance of variables that shape the market development.

Global Methylidenesuccinic Acid Market Segment By Type: Synthesis, Fermentation, ,

Global Methylidenesuccinic Acid Market Segment By Application: Plasticizer, Lubricating Oil Additive, Others, ,

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Why Report Hive Research:

Report Hive Research delivers strategic market research reports, statistical surveys, industry analysis and forecast data on products and services, markets and companies. Our clientele ranges mix of global business leaders, government organizations, SMEs, individuals and Start-ups, top management consulting firms, universities, etc. Our library of 700,000 + reports targets high growth emerging markets in the USA, Europe Middle East, Africa, Asia Pacific covering industries like IT, Telecom, Semiconductor, Chemical, Healthcare, Pharmaceutical, Energy and Power, Manufacturing, Automotive and Transportation, Food and Beverages, etc.

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COVID-19 Impact on Methylidenesuccinic Acid Market Top Manufacturers, Types and Application 2020| Kehai Biochemistry, Alpha Chemika, Guoguang...

Methylene Succinic Acid Market By Coronavirus-Covid19 Impact Analysis With Top Companies and Regions by Forecast to 2026| Itaconix Corporation,…

Global Methylene Succinic Acid Industry Amid Global COVID-19 Crisis: Report Hive Viewpoint

Chicago, United States: Global Methylene Succinic Acid Market Report offers detailed research and analysis of key aspects of the global Methylene Succinic Acid market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Methylene Succinic Acid market. Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Methylene Succinic Acid market is carefully analyzed and researched about by the market analysts. The market analysts and researchers have done extensive analysis of the global Methylene Succinic Acid market with the help of research methodologies such as PESTLE and Porters Five Forces analysis.

Methylene Succinic Acid Market provided accurate and reliable market data and useful recommendations with an aim to help the players gain an insight into the overall present and future market scenario. The Methylene Succinic Acid report comprises in-depth study of the potential segments including product type, application, and end user and their contribution to the overall market size.

Key Companies/Manufacturers operating in the global Methylene Succinic Acid market include: Itaconix Corporation, Aekyung Petrochemical Co. Ltd., Jinan Huaming Biochemistry Co. Ltd., Qingdao Langyatai Group Co., Ltd., Shandong Kaison Biochemical Co., Ltd., Zhejiang Guoguang Biochemistry Co., Ltd., Ronas Chemicals Ind. Co., Ltd., Alpha Chemika, Iwata Chemical Co., Ltd., Chengdu Jinkai Biology Engineering Co., Ltd., Ultimate Chem India Pvt. Ltd., Shandong Shunda, Nanjing Huajin Healthcare Biologicals Co. Ltd., Citrus Food Additives Co., Ltd, Shandong Zhongshun Science & Technology Development Co., Ltd., ,

Get PDF Sample Copy of the Report to understand the structure of the complete report: (Including Full TOC, List of Tables & Figures, Chart): https://www.reporthive.com/request_sample/2353513

Methylene Succinic Acid Market is split by Type and by Application. For the period 2015-2025, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

Methylene Succinic Acid Market Segment by Type covers: Styrene Butadiene Itaconic Acid, Methyl Methacrylate, Polyitaconic Acid, Others, ,

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Regional analysis covers:

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Key questions answered in the report:

* What is the growth potential of the Methylene Succinic Acid market?

* Which product segment will grab a lions share?

* Which regional market will emerge as a frontrunner in the coming years?

* Which application segment will grow at a robust rate?

* What are the growth opportunities that may emerge in the Methylene Succinic Acid industry in the years to come?

* What are the key challenges that the global Methylene Succinic Acid market may face in the future?

* Which are the leading companies in the global Methylene Succinic Acid market?

* Which are the key trends positively impacting the market growth?

* Which are the growth strategies considered by the players to sustain hold in the global Methylene Succinic Acid market

Why Report Hive Research:

Report Hive Research delivers strategic market research reports, statistical surveys, industry analysis and forecast data on products and services, markets and companies. Our clientele ranges mix of global business leaders, government organizations, SMEs, individuals and Start-ups, top management consulting firms, universities, etc. Our library of 700,000 + reports targets high growth emerging markets in the USA, Europe Middle East, Africa, Asia Pacific covering industries like IT, Telecom, Semiconductor, Chemical, Healthcare, Pharmaceutical, Energy and Power, Manufacturing, Automotive and Transportation, Food and Beverages, etc.

Contact Us:

Report Hive Research

500, North Michigan Avenue,

Suite 6014,

Chicago, IL 60611,

United States

Website: https://www.reporthive.com

Email: [emailprotected]

Phone: +1 312-604-7084

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Methylene Succinic Acid Market By Coronavirus-Covid19 Impact Analysis With Top Companies and Regions by Forecast to 2026| Itaconix Corporation,...