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How to stay socially connected as lockdown returns – according to science – The Conversation UK

After a fairly relaxed summer, more and more places are bringing back tighter restrictions in response to rising COVID-19 cases, with some even returning to full or near-full lockdowns.

We all know that social distancing makes sense: the fewer people we meet (and the further away from them we stay), the less likely we are to get ill or to spread the virus. But sticking to social distancing is hard. And the longer we do it, the harder it seems to get.

Recent findings from social neuroscience may offer some insights on how we can nonetheless stay socially connected. Hopefully, this will help us cope better if only just a little.

Being socially connected to others makes us feel safe and cared for, and this feeling affects our body and brain. We worry less about potential dangers and feel less stressed, sleep better, have lower heart rate and blood pressure, our baseline energy requirement is lower, and our immune system works more efficiently. We are also less prone to depression.

This is because when calculating the available cognitive and bodily resources, our brain naturally takes our nearest social surroundings the people we interact with into account. It treats social and metabolic resources almost interchangeably. If we can count on other people to support us in times of need, our own resources can either be preserved or dedicated to other issues, as if they were literally increased.

Recent social neuroscience findings suggest that these beneficial effects have a lot to do with becoming synchronised with others, by paying attention to or thinking about the same thing at the same time and to have the ability to react to one another instantly.

We usually do this through physical touch, eye contact, talking to each other, sharing our emotions, and following each others behaviour such as bodily gestures. We call this bio-behavioural synchrony.

There is growing evidence that being in synchrony with others increases cooperation, social connection and positive thoughts about others, and also lifts our spirits. It can also ease our pain, reduce stress and boost our resilience our ability to stay positive and healthy despite facing adversity.

This means we should embrace virtual interaction for our work meetings, quick chats and socially distanced workouts, quizzes or movie nights. It wont be the same as before, but we can still get some of this feeling of synchrony with others that is so important for us.

Whats more, recent insights reveal that virtual interactions can stimulate comparable bodily and brain responses to those from real-world interactions. For example, making eye contact with someone over a video call has similar effects, physiologically and psychologically, as a real interaction involving eye contact.

There is also evidence that brain areas related to social reward and mind-reading show stronger activation during a live online social interaction than when watching the same interaction content as a recorded video. Hearing a loved ones voice may even be enough to decrease the stress hormone cortisol and increase the social bonding hormone oxytocin - but you dont get this reaction from just reading a text from the same person.

Other research even shows that imagining a loved ones presence (with the help of a photo) when anticipating or feeling pain significantly decreases brain activity related to pain, as well as your subjective experience of it very much as if the loved one was with you holding your hand.

Social connection is a strongly subjective, inner experience. We can have a thousand friends but still feel lonely. It is not physical, objective social isolation that makes our body and mind ill, but our perceived social isolation or loneliness.

One way to maintain or even create a stronger sense of social connection from within is to be kind and compassionate towards and help others. There is ample evidence that by acting prosocially in this way, we become happier and healthier by ourselves.

This is because generating a compassionate attitude from within is associated with activation of positive emotion- and reward-related brain regions and hormonal pathways. We can even put ourselves in this state by being on our own and simply wishing others well and good health through meditation. In this sense, we can literally help ourselves by helping others.

We also shouldnt be afraid of reaching out to others, to follow our natural tendency to let others know that we are not fine and need support. Almost always, somebody will respond, because we are not only made to shout out if we need help (using our innate attachment system), but we are also made for helping others if they need it (using our innate caregiving system.

Although the virtual space can be hostile sometimes, it has recently shown to also be full of compassion and social warmth. And the same appears to hold true when reaching out in a more old-fashioned, analogue way.

The field of positive psychology says that we have a unique ability to learn optimism in the face of adversity, and that we should build upon our propensity for getting through periods of trauma with a developed sense of personal growth and an increased inner-strength. Social neuroscience has shown us that we can do it best if we do it together.

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How to stay socially connected as lockdown returns - according to science - The Conversation UK

A Virtual Twist on Tradition: Founders Day Will Feature Visual Contests, Messages – University of Texas at Dallas

From left: Cecil Green, Erik Jonsson and Eugene McDermott displayed the dedication plaque for the Founders Building. On Oct. 29, 1964, the Founders Building, the first permanent structure at The University of Texas at Dallas, was dedicated.

UT Dallas campuswide celebration of Founders Day will look a little different this year. The day that honors the Universitys three founders will be delivered in a virtual format and will include online contests and giveaways.

The University community is invited to participate in a photo mosaic in place of the traditional group photo. The first 600 people who send photo submissions will receive this years commemorative Founders Day T-shirt. All photo submissions will be entered into a drawing for a limited edition Temoc statue as well. Celebrations this year will also include an Instagram Reels challenge.

Capture your best Whoosh video on Instagram Reels for a chance to win a UT Dallas swag bag.

Thursday, Oct. 29, marks the 56th anniversary of the date the Founders Building was dedicated in 1964. It is also the day the University celebrates the vision and legacy of its founders: Eugene McDermott, Erik Jonsson and Cecil Green. The area where UT Dallas first building stands was originally surrounded by acres of cotton fields and undeveloped land, and it served as the central facility of the Graduate Research Center of the Southwest, a private research institution that in 1969 became UT Dallas.

Founders McDermott, Jonsson and Green established the center because they wanted to retain and cultivate the engineering talent at their firm, Texas Instruments Inc. They had witnessed bright young people moving out of the region to pursue advanced education elsewhere and aimed to create an institution that would foster learning, further research and attract the most influential minds of the day.

Founders Day virtual events also will include the story of the founders as told by three students: Yushra Rashid, a neuroscience senior, Green Fellow and student ambassador; Ayala Ben David, a chemistry senior and Green Fellow; and Patrick Nnoromele, neuroscience senior, Eugene McDermott Scholar and student ambassador.

There also will be a message called You Are the Founders Vision from UT Dallas President Richard C. Bensonand University vice presidents and deans. Both videos will be available on the Founders Day website.

We are pleased to present Founders Day as a virtual event this year and again celebrate this important tradition, said Kyle Edgington PhD13, vice president for development and alumni relations. We are excited to honor these founders, who laid the groundwork to create educational opportunities and train more scientists and researchers to serve not only the state, but the country and the world.

The first 600 people who submit photos will be emailed directly about where they can select their shirt size and schedule a pickup time.

The winner of the Instagram Reels challenge will be announced via social media the afternoon of Founders Day and contacted with instructions on collecting the prize. The contests are open to faculty, staff, students and alumni.

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A Virtual Twist on Tradition: Founders Day Will Feature Visual Contests, Messages - University of Texas at Dallas

UW jumps two spots to No. 8 in US News Best Global Universities ranking | UW News – UW News

Administrative affairs | Education | For UW employees | Health and medicine | Honors and awards | News releases | Population Health | Public Health | Research | Science | Social science | UW and the community

October 20, 2020

The University of Washington moved up two spots to No. 8 on theU.S. News & World Reports Best Global Universities rankings, released Tuesday. The UW maintained its No. 2 ranking among U.S. public institutions.

We are proud to be consistently recognized for the excellence and impact of our scholarship across so many subjects, UW President Ana Mari Cauce said. Its especially gratifying to see the work of outstanding programs like infectious diseases and immunology listed among the very best in the world at a time when we need discovery and innovation in these areas more than ever.

U.S. News also ranked several subjects, and the UW landed in the top 10 in 10 subject areas, including infectious diseases (No. 6) and computer science (No. 9) joining the top 10 since last years rankings were released. The UW also moved up to No. 6 from No. 10 in immunology.

The ranking methodology which is based on Web of Science data and metrics provided by Clarivate Analytics InCites weighs factors that measure a universitys global and regional research reputation and academic research performance. For the overall rankings, this includes bibliometric indicators such as publications, citations and international collaboration.

The overall Best Global Universities ranking, now in its sixth year, encompasses the top 1,500 institutions spread across 81 countries, up from 75 countries last year, according to a press release from U.S. News.American universities make up eight of the top 10 spots.

Here are all of the top 10 UW rankings in U.S. News subject rankings:

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UW jumps two spots to No. 8 in US News Best Global Universities ranking | UW News - UW News

Should you get the first coronavirus vaccine available? A 60-year-old scientific doctrine may have the answer – San Francisco Chronicle

People desperate for a coronavirus cure might not want to take the first vaccine that comes along if a better one is likely to come around later.

That is one interpretation of a 60-year-old medical doctrine that may be as relevant as ever, given the Trump administrations push to rush out a vaccine before years end.

The Doctrine of Original Antigenic Sin, also known as the Hoskins effect, holds that the antibodies generated by the strain of flu a person first encounters remain in the body for life and affect how the body responds to future infections and vaccinations.

Dr. Jay Levy, a professor of medicine at UCSF, said the doctrine suggests that a person inoculated with a vaccine for COVID-19 might develop an immunological memory to that specific vaccine, which would prevent him or her from benefiting from stronger vaccines produced later.

The concept is that if you are given, by chance, a less effective vaccine and then later you are given a strong one, your body might not respond to the strong one ... because the immune system thinks its getting the same vaccine and it wont improve the response, said Levy, a specialist in immunology and virology. So the message really is, we dont want to rush into this. We need the vaccine, but we want to make sure weve got as good a vaccine as we can make.

Not all infectious disease specialists agree with that concept and even if it were so, there are many caveats but experts say it is something that should be considered in the frantic worldwide race to come out with a drug that will halt the pandemic.

Scientists and medical professionals across the country have expressed concern about President Trumps recent declarations about the speed with which he expects a COVID-19 vaccine to be produced. Most experts do not believe that ambitious timeline provides enough time to complete drug trials, certify that a vaccine is safe and effective, produce millions of doses, transport it around the country, and distribute it to everyone this year.

But an even bigger worry is that important steps might be skipped in order to produce a coronavirus vaccine as quickly as the president wants, and that could lead to a flawed product. If, in that case, Levys interpretation of the Doctrine of Original Antigenic Sin holds true, it would mean millions of people could be inoculated with an inferior vaccine and be stuck with the consequences.

Robert Siegel, an infectious disease specialist at Stanford University, said the doctrine is a fascinating concept, but it doesnt address coronaviruses and is more nuanced than just saying people bedeviled by the pandemic are stuck with taking only one vaccine.

I am far more concerned about the release of an inadequately tested vaccine that is not safe and/or efficacious, Siegel said. I am also concerned that a prematurely released vaccine could hinder the ability to do proper testing on that vaccine or on other potential vaccine candidates.

The original paper on the Doctrine of Original Antigenic Sin was published by Dr. Thomas Francis in the Dec. 15, 1960, edition of the Proceedings of the American Philosophical Society.

The concept, first named by Francis in the 1950s and later dubbed first flu is forever, described how the imprint made by that first virus governs antibody response to vaccinations with other strains. The paper said antibodies from that first strain are amplified, or bolstered, by every subsequent exposure to the flu.

In a nutshell, it means that doctors can test peoples blood and determine which strain of influenza was around when they were kids. It also suggests that booster shots for that strain can provide useful protection against other similar strains.

If, however, a new strain of flu different from the original is encountered later in life, the cellular memory established in that first infection would tend to delay or dampen the effectiveness of the immune response, according to the doctrine.

A 2017 paper published in the Journal of Infectious Diseases cited studies in the United States and Canada that indicated that prior influenza vaccination can, in certain situations, produce actual increased susceptibility to infection.

Siegel said this phenomenon has been seen in the mosquito-borne tropical virus called Dengue fever, which has four serotypes, or strains, or five if you count the Zika virus.

In this case, a secondary infection with a different strain not only interferes with the proper immune response, it actually causes the response to go haywire and make the clinical disease worse than if the person had never been exposed to Dengue, said Siegel, describing what he called antibody dependent enhancement.

The antigenic sin concept is still being debated six decades after Francis came up with it. The 2017 paper said the doctrine is still invoked to explain observations that may but often may not relate to its original description, such as reductions in the response to antigens in flu vaccines.

And it is an open question whether the doctrine applies to SARS-CoV-2, the specific coronavirus that causes COVID-19, Siegel said. For all anybody knows, he said, taking two different vaccines might result in cross protection against different strains, which would be a good thing.

The first vaccine for shingles, a painful skin infection caused by the same virus that causes chicken pox, was later improved upon and no adverse effects were reported in people who took both versions.

But the possibility does exist that an inadequately tested coronavirus vaccine could interact with a different strain still circulating in the population and hinder the bodys ability to make strong neutralizing antibodies. That could potentially leave people unprotected or even enhance disease, Siegel said.

In theory, this could happen if there were two vaccines aimed at the same protein from two different strains of the virus, Siegel said. But in a properly tested vaccine, this eventuality would be detected before the vaccine was licensed.

Bad outcomes like that may be unlikely, he said, but we need to get the actual data to determine which of these possibilities is correct.

The race for a cure in the United States is largely being driven by Operation Warp Speed, designed by the Trump administration to cut bureaucratic red tape and speed the approval process.

The pharmaceutical firms leading the race Pfizer, Moderna, AstraZeneca and Johnson & Johnson have vowed not to seek government approval for any vaccine that hasnt proven to be safe and effective. That means testing it on people of different ages, genders and ethnicities and on different strains and lineages of the virus to see if there are side effects, a process most believe wont be complete until at least the spring.

Original antigenic sin may or may not come into play, Siegel and Levy said, but the mere possibility is reason enough not to bypass science and rush an unproven coronavirus vaccine into use.

Peter Fimrite is a San Francisco Chronicle staff writer. Email: pfimrite@sfchronicle.com. Twitter: @pfimrite

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Should you get the first coronavirus vaccine available? A 60-year-old scientific doctrine may have the answer - San Francisco Chronicle

Protein by which common skin bacteria trigger eczema identified – The University of Manchester

The search for the missing link involved mouse eczema model studies led by Tokyo University of Agriculture and Technology, and bench work on cells and human skin tissue at Manchester.

The scientists also studied six other species of staphylococci, as well as the common Group A strep which causes tonsillitis and scarlet fever, but none generated allergic responses.

In each part of the study, the results pointed to Sbi - first discovered in 1998 - as the trigger.

Dr Pennock, from The University of Manchester said: Our primary aim was to understand why Staphylococcus aureus is so uniquely associated with allergic reactions in skin.

The precise mechanism that drives the allergic pathology in eczema patients has been a mystery, until now.

Staphylococcus aureus expresses many virulence factors so finding the right protein was a challenge. We have shown that only golden Staph that expresses Sbi is capable of causing the allergic skin response.

Now our aim is to learn more about Sbi in order to lay the groundwork for future non-steroid treatments. We are very grateful to the Leo Foundation for continuing to fund this exciting work.

The paper Staphylococcus aureus Second Immunoglobulin-Binding Protein drives atopic 2 dermatitis via IL-33 is published in theJournal of Allergy and Clinical Immunology

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Protein by which common skin bacteria trigger eczema identified - The University of Manchester

Evidence for a DNA Methylation Signature of ASD in Cord Blood – Technology Networks

A new study led by UC Davis MIND Institute researchers found a distinct DNA methylation signature in the cord blood of newborns who were eventually diagnosed with autism spectrum disorder (ASD). This signature mark spanned DNA regions and genes linked to early fetal neurodevelopment. The findings may hold clues for early diagnosis and intervention.

"We found evidence that a DNA methylation signature of ASD exists in cord blood with specific regions consistently differentially methylated," saidJanine LaSalle, lead author on the study and professor of microbiology and immunology at UC Davis.

The studypublished Oct. 14 inGenome Medicinealso identified sex-specific epigenomic signatures that support the developmental and sex-biased roots of ASD.

The U.S. Centers for Disease Control and Prevention (CDC) estimates that one in 54 children are diagnosed with ASD, a complex neurological condition linked to genetic and environmental factors. It is much more prevalent in males than females.

The epigenome compounds do not change the DNA sequence but affect how cells use the DNA's instructions. These attachments are sometimes passed on from cell to cell as cells divide. They can also be passed down from one generation to the next. The neonatal epigenome has the potential to reflect past interactions between genetic and environmental factors during early development. They may also influence future health outcomes.

The researchers also analyzed the umbilical cord blood samples taken at birth from the delivering mothers. They performed whole-genome sequencing of these blood samples to identify an epigenomic signature or mark of ASD at birth. They were checking for any patterns of DNA-epigenome binding that could predict future ASD diagnosis.

They split the samples into discovery and replication sets and stratified them by sex. The discovery set included samples from 74 males (39 TD, 35 ASD) and 32 females (17 TD, 15 ASD). The replication set was obtained from 38 males (17 TD, 21 ASD) and eight females (3TD, 5 ASD).

Using the samples in the discovery set, the researchers looked to identify specific regions in the genomes linked to ASD diagnosis. They tested the DNA methylation profiles for DMRs between ASD and TD cord blood samples. They mapped the DMRs to genes and assessed them in gene function, tissue expression, chromosome location and overlap with prior ASD studies. They later compared the results between discovery and replication sets and between males and females.

"Findings from our study provide key insights for early diagnosis and intervention," LaSalle said. "We were impressed by the ability of cord blood to reveal insights into genes and pathways relevant to the fetal brain."

The researchers pointed out that these results will require further replication before being used diagnostically. Their study serves as an important proof of principle that the cord blood methylome is informative about future ASD risk.

Reference: Mordaunt CE, Jianu JM, Laufer BI, et al. Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes. Genome Medicine. 2020;12(1):88. doi:10.1186/s13073-020-00785-8.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Evidence for a DNA Methylation Signature of ASD in Cord Blood - Technology Networks

Trans-Hit Biomarkers Announces Today a Partnership With Nexelis, Supporting Sample Procurement Activities for a Number of Strategic Projects Including…

Under the terms of the agreement, THB will manage Nexelis biospecimen procurement activities, consolidating Nexelis current sourcing channels with those of THB spanning over 20 countries worldwide.

Benoit Bouche, Nexelis Chief Executive Officer said: Fast access to quality samples is essential for turnaround and lead time purposes, and is a clear bottleneck in a number of immunology projects. We have been collaborating with Trans-Hit Bio on a number of occasions and highly appreciate their reactivity and professionalism coupled with a scientific rigor that we believe to be key to the success of Nexelis.

Dr. Pascal Puchois, Chief Executive Officer at THB added, We are pleased and excited to work with this rapidly growing leader in the bioanalytical domain, and we are eager to support Nexelis important mission. Since fit-for-purpose biospecimens are crucial for the successful validation of new assays, it is important for our partners to have full confidence in the manner in which the samples were consented, collected, and shipped. On behalf of Trans-Hit Bio and our entire team, we look forward to working closely with Nexelis, and managing their biospecimen procurement activities.

About Nexelis

With unrivaled expertise in immunology, and operating sites in North America (East and West Coast) and Europe, Nexelis is a leading provider of assay development and advanced laboratory testing services in the infectious diseases, metabolic diseases, and oncology fields. Our versatile team of scientists, working with our advanced technology platforms, were instrumental in the development, qualification, validation, and large-scale sample testing of assays that supported the FDA filing of almost 100 new molecular entities, including blockbuster vaccines, anti-viral drugs, and immunotherapy, gene and cell therapy products.

About Trans-Hit Bio

Trans-Hit Biomarkers Inc is a worldwide biospecimen procurement CRO with the most extensive collection capability for biospecimens and clinical samples through an unrivalled worldwide partnered network of clinical partners and biobanks. The company, led by a team with a solid background in biomedical research, advises and provides biopharma and diagnostic clients with the best solutions to help design, organize, and conduct sample collections in various fields including oncology, infectious and CNS diseases, among others. THB manages the entire biospecimen acquisition process, from the initial sample request, to the moment the samples are delivered, and beyond. To learn more about THB, please, visit http://www.trans-hit.com.

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Trans-Hit Biomarkers Announces Today a Partnership With Nexelis, Supporting Sample Procurement Activities for a Number of Strategic Projects Including...

Anatomy of . . . US swimmer Caeleb Dressel | Sport | The Sunday Times – The Times

US swimmer is the worlds leading sprinter and is currently starring in the latest International Swimming League edition

DietHes not at Michael Phelps level (8,000-10,000 a day) for calorie intake, starting the day with bagel, toast or oatmeal with honey. After two hours in the pool, he heads to the weight room where he tops up with a chocolate milk or energy bar. Two more hours in the gym is followed by breakfast-lunch, which consists of carbs, protein, fruit and vegetables. I could eat seafood every meal, but if I cook at home, itll usually be some type of chicken. I graze throughout the day on apples and oranges. After sleep and afternoon practice, he enjoys his final meal of the day. His favourite?

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Anatomy of . . . US swimmer Caeleb Dressel | Sport | The Sunday Times - The Times

Anatomy of a Killing by Ian Cobain review a death that casts new light on the Troubles – The Guardian

In certain parts of Northern Ireland in the late 1970s, a stranger arriving at the door could provoke panic, even terror. The town of Lisburn, near Belfast, was not such a place. Predominantly Protestant and home to many members of the Royal Ulster Constabulary (RUC), it had for the most part escaped the violence that had ravaged other parts of the province. Up until 1977, as Ian Cobain puts it, not a single member of the security forces had lost their life in Lisburn.

All that would change on the morning of Saturday, 22 April 1978, when Millar McAllister, a police photographer, opened the back door of his home in Woodland Park, having glimpsed a figure moving in his back garden. He was shot three times at close range, twice in the chest and the third time, as he was lying on the ground, in the head. In the silence that followed, the killer noticed McAllisters seven-year-old son, Alan, standing just inside the kitchen door, frozen to the spot. They stared at each other for a long moment until the boy started screaming. The stranger ran to a waiting car, the boys cries echoing in his head,

In Lost Lives, the vast book of historical record that chronologically documents every death in the Troubles, Millar McAllister is listed as victim number 2,017. The bare facts of his life are outlined thus: RUC, Protestant, 36, married, two children. In Anatomy of a Killing, Ian Cobain rescues him from the abyss of history, tracing the arc of his short life and contrasting it with the still ongoing, altogether more tangled, life of Harry Murray, his killer.

By reconstructing a single murder its planning, its ruthless execution and its protracted aftermath through in-depth interviews and the careful sifting of not always reliable evidence from official records, Cobain also casts new light on the culture of terrorist violence and state repression that defined Northern Ireland during 30 years of conflict.

Cobain is a seasoned, award-winning investigative journalist (most recently for the Guardian), who also sketches the social and historical context that spawned the Troubles. Throughout, his style is brisk and his tone level-headed, the violence he chronicles often evoked through spartan, but chillingly descriptive, detail. Of the aftermath of the IRA bombing of the La Mon hotel restaurant, which happened on 17 February 1978, just a few months before the murder of Millar McAllister, he writes: Twelve people, including three married couples, died in the blast. All were Protestant. The dead were so badly burned and shrivelled by the flames that firemen thought initially that some of them were children. Hell is in the details.

Amid such carnage, the death of an individual could pass all too swiftly into the anonymous realm of statistics, forgotten by all but family members and loved ones. Cobains book is, among other things, an act of reclamation. It is also, in its skilful telling, a tale of two ordinary lives converging with the inexorability of a Greek tragedy.

Millar McAllister joined the RUC in 1961, when the Troubles, as Cobain puts it, were barely visible on the horizon. He had two hobbies: photography and racing pigeons. The former provided him with a well-paid job; the second unwittingly led to his death. McAllister wrote a monthly column for Pigeon Racing News and Gazette under the byline The Copper, which was accompanied by his photograph. When an IRA suspect, who was being held at the Castlereagh interrogation centre in east Belfast, recognised McAllister from the photo, the word went out to find him. Soon afterwards, Harry Murray was dispatched with another young volunteer to carry out his execution.

In almost every way, Murray comes across as the polar opposite of the level-headed McAllister: impetuous, impressionable and instinctively rebellious. What they had in common is that they were both Protestants, Murray being one of the very few from his community to join the IRA. A few years before, he had been driven out of his home in loyalist Tigers Bay in Belfast by local paramilitaries. His transgression was to marry a Catholic. Having been resettled where his wife grew up in nationalist north Belfast, he grew increasingly sympathetic to the republican cause. Murray seems to have drifted into the ranks of the Provisionals much like, years before, he had enlisted on impulse with the Royal Air Force and served overseas. His military career ended abruptly after one too many breaches of discipline. I just couldnt take orders, he tells Cobain without irony.

Murrays renegade life was not without principle, however. During his induction into the IRA, he claims to have told his recruiters there were two things he would not do: kneecappings and shooting Protestants just because they were Protestant. Like all IRA combatants, though, he regarded the RUC as the enemy in a just war, and, as Cobain discovers, remains remarkably free of remorse for the brutal taking of Millar McAllisters life. In 1983, while serving time for the killing, Murray would take part in an audacious IRA jailbreak from Long Kesh prison, shooting a prison officer in the leg before being wounded himself. On his recapture, he was set upon by prison officers who berated him as a turncoat bastard.

As with Patrick Radden Keefes recent book, Say Nothing, which uses the IRAs disappearance of Jean McConville in 1972 as the starting point for an illuminating exploration of the conflict, Anatomy of a Killing deftly merges history, social context and anecdotal testimony. Cobain explores the psychology of political violence, citing a study from 1978 which found that, rather than being the psychopaths of tabloid headlines, the IRAs political killers tended to be normal in intelligence and mental stability. He also suggests that vengeance may have been a crucial motivating factor for young men joining the Provisionals and, in Murrays case, it is clear that he has never forgiven his own community for the humiliation of his expulsion.

The immediate aftermath of the killing also makes for deeply unsettling reading. On information obtained from an IRA informer, Murray and his accomplices were arrested and taken to Castlereagh, where they were beaten and interrogated relentlessly by Special Branch men working in shifts. Anne, an IRA courier, confesses to her role and, Cobain writes, appears to have suffered a fairly complete physical and psychological breakdown.

The man she gave the gun to after the killing, Brian Maguire, whom Cobain describes as highly strung, was not an IRA member. He was interrogated non-stop for 12 hours and, the next morning, was found hanged in his cell. His death remains disputed. Among the revelations in Cobains book is testimony given at the time by another suspect called Phelim, which provides what Cobain calls an accurate description of the torture technique that became known as waterboarding when used by the CIA in the years after 9/11.

If there is much that is compelling in Anatomy of a Killing, what lingers longest is the awful mundanity of the events leading up to and after the killing. Cobain describes how, on that fateful morning, Anne calmly carried the gun from Belfast to Lisburn on a bus, and, having arrived early, went shopping for a birthday present for her brother. Just a few hours after he killed McAllister, Murray returned to Lisburn to play football on a pitch close to his victims home.

As the Troubles begin to fade into history and forgetting, it is in these incidental actions that the deep moral fracture caused by the conflict comes sharply and chillingly into focus. We would do well to remember how quickly violence can become almost normalised in a culture riven by intractable differences of identity and belonging.

Anatomy of a Killing: Life and Death on a Divided Island by Ian Cobain is published by Granta (18.99). To order a copy go to guardianbookshop.com. Delivery charges may apply

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Anatomy of a Killing by Ian Cobain review a death that casts new light on the Troubles - The Guardian

Sandra Oh Stays In Touch With Her Old ‘Grey’s Anatomy’ Co-Stars: ‘They Became Like Family Members’ – Access Hollywood

Sandra Oh is still close with her Greys Anatomy family. The Killing Eve actress told Access Hollywoods Sibley Scoles, I was just recently in touch with Kevin McKidd. Kevin and I are very, very close, you know? And then, having seen a couple of cast members in the past couple years, you know, its been great to kind of stay in touch with them They became like family members to me. Sandra also opened up about the joy of working on the new animated film Over the Moon, which is out now on Netflix and in select theaters.

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Sandra Oh Stays In Touch With Her Old 'Grey's Anatomy' Co-Stars: 'They Became Like Family Members' - Access Hollywood