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Human Behavior

Spring Arbor University Launches Online Bachelor of Science in Human Services, Prepares Students to Aid Those at Risk of Social and Economic…

SPRING ARBOR, Mich., Oct. 30, 2020 /PRNewswire/ --Spring Arbor University (SAU) today announced the launch of its online Bachelor of Science in Human Services degree program.

The program is designed to ready its graduates to work in public and private sectors, emphasizing the general study and provision of human and social services to individuals, groups and communities. Designed to ready its graduates to work in public and private human services agencies and organizations, the program emphasizes the general study and provision of human and social services to individuals, groups and communities. Spring Arbor University blends its unique approach of the liberal arts tradition, total commitment to Jesus Christ as the perspective for learning and critical participation in the contemporary world. The program also is advantageous for those planning to pursue a master's degree in counseling or social work.

The versatile knowledge and skills gained during study prepare students for real-world employment in a human-services related field, such as counseling, social work, criminal justice, or a nonprofit or faith-based human services organization. Jobs could include social and community service manager; social services care coordinator/case manager; probation officer/correctional treatment specialist; patient/client/victim advocate; community outreach specialist/community liaison; bereavement/grief specialist; crisis intervention specialist; or administrators of nonprofit and faith-based organizations.

The interdisciplinary degree focuses on the human experience, establishing foundational knowledge in four primary sectors: psychology and human behavior; sociology and social work; research design and methods; and communication and business. The curriculum comprises of instruction in the social sciences, psychology, social service principles, human services policy, planning and evaluation, social services law and administration, and applications to human services issues, services, localities and populations.

"The Human Services major builds on SAU's strengths in online learning and the helping professions," said Carol Green, Ph.D., vice president for academic affairs. "We designed the program based on what we heard from professionals working in the field as to the skills and knowledge needed for those jobs. Students with lots of transfer credits will love how the flexibility will allow them to finish their bachelors quickly. And, it creates a nice pathway to a master's degree. The degree will prepare students to make a significant difference in our world."

According to the U.S. Bureau of Labor Statistics, graduates with human services degrees can expect a bright outlook. With a 17 percent growth rate through 2029, opportunities in the field are growing at a faster than average pace.

In parallel with Spring Arbor University's mission, individual courses integrate a Christ-centered worldview into the educational experience by applying Biblical principles to concepts or practices in class activities and assignments. This approach to faith-based learning emphasizes compassion, human dignity, justice, ethics and cultural understanding.

Courses are offered completely online, with no required physical campus visits and with multiple starting dates throughout the year, allowing students to begin their educational journey when it's convenient to them. Most courses run in six-week blocks, which means sooner completion and better use of Pell Grant funding, if applicable. The program is ideal for students with significant transfer credits and accepts transfers of up to 84 college credits.

The new online bachelor's degree in human services is accredited by the Higher Learning Commission, ensuring students receive a rigorous education that meets today's highest industry standards.

Learn more about Spring Arbor University's Bachelor of Science in Human Services degree at https://programs.online.arbor.edu/programs/human-services-degree

Founded in 1873, Spring Arbor University is a Christian liberal arts university located in Spring Arbor, Michigan. SAU offers more than 70 majors and programs to traditional undergraduate students, as well as associate, bachelor, and master programs offered in virtual class formats. For more information, visit arbor.edu.

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Spring Arbor University Launches Online Bachelor of Science in Human Services, Prepares Students to Aid Those at Risk of Social and Economic...

Human Behavior

Which mask works? Researchers find confusion over mask use for wildfire, COVID-19 crises – Stanford University News

To mask or not to mask and which mask to use? With public health guidance about masks in the United States confused by political hedging, clarity around mask use is increasingly important, especially as the western U.S. battles the twin crises of wildfire smoke and COVID-19.

The CDC is the gold standard of where we find guidance to protect our health, but its also really important for that information to be spread in ways that people can access and understand it, said Francisca Santana, a PhD student at Stanford University and lead author of a perspective review on mask use published in Environmental Research Letters Oct. 28. Unfortunately, just a website online may not be effective at communicating that information.

The researchers analyzed studies on large-scale responses to epidemics, drivers of human behavior and reactions to wildfire smoke exposure. Based on what scientists have gleaned in aggregate, they have outlined recommendations for communicating mask use guidelines. For U.S. government agencies, their suggestions include:

Even people who understand what they should be doing are not doing it, said senior author Gabrielle Wong-Parodi, an assistant professor of Earth system science at Stanfords School of Earth, Energy & Environmental Sciences (Stanford Earth). The message needs to be evidence-based, and we need to provide people with behaviorally realistic options that they can actually do and afford.

The researchers noted the importance of incorporating the social and psychological influences of mask use behavior a critical and poorly understood topic they urge scientists to further investigate. We are social beings, we live in these social contexts and were not making decisions in isolation, so thats really important to acknowledge in whatever messages are given to the public, Wong-Parodi said. Just because we put out a great message doesnt mean that people are going to take it up and do it we need to be sensitive to what people are going through right now.

One pathway to behavior change is through social norms the shared beliefs within a social group. Common methods for establishing social norms include comparing peoples actions to others, providing positive feedback and placing messaging where it is most relevant. That could mean, for example, posting signage about wildfire masks outdoors and COVID-19 masks indoors.

Further investigation is needed to understand if mask wearing can also affect other actions to prevent the spread of infectious disease, such as hand-washing and social distancing, according to the co-authors.

To help fill gaps in research on mask use during wildfires, Santana, a PhD student in the Emmett Interdisciplinary Program in Environment and Resources, interviewed residents affected by wildfire smoke from the 2018 Camp Fire that destroyed Paradise, California.

The discussions indicated that social norms are a powerful driver of mask use, but also revealed instances of maladaptive behavior, when the action taken is ineffective or even harmful. In one interview, Santana learned that during persistent wildfire smoke, someone with asthma wore a mask while sleeping a practice that can even further stress breathing for people with pre-existing asthmatic conditions. That highlighted how some of the basic information about how to wear a mask how to fit it, what conditions should you wear it in was not permeating all the communities that we were working in, Santana said.

Unlike situations of infectious disease alone, the dual threats of wildfire smoke and COVID-19 have presented a plethora of mask-wearing options with varying effectiveness, depending on the hazard. While an N95 mask is form fitting and must be placed on top of your nose to protect from wildfire smoke, cloth face coverings may be advised forCOVID-19 protection and people sometimes wear less-structured cloth masks under their noses, going against the CDCs recommendation to wear them over your nose and mouth to reduce disease transmission.

The interviews also revealed a form of social support that is now being repeated during COVID-19: gifting masks to others. While it may or may not actually encourage mask use, that support can influence how people perceive the behaviors of close friends and family.

Your perception of the behavior of people youre in close contact with matters maybe even more than what theyre actually doing, in terms of influencing your own behavior, Wong-Parodi said.

The review also included surveys from China and Japan, where mask-wearing was associated with the perceived threat of pandemics like SARS and H1N1 and strong perceived benefits of masks. More recent research in the U.S. reveals how mask use can indicate political affiliation or fear of racial profiling.

The researchers suggest several areas of study that would help public health communications leverage the social nature of mask use, such as how social norms influence individual health like the inhalation of smoke versus collective health such as the spread of COVID-19. Above all, they underscore the importance of communications based on scientific evidence.

Its really important for public health officials at the local or state level to provide clearer guidance to the public about which masks are appropriate for which events, and to make recommendations for behavior change, Santana said.

Wong-Parodi is also a center fellow at the Stanford Woods Institute for the Environment. Co-authors include Stephanie Fischer, a social science research coordinator with the Woods Institute, and Marika Jaeger, a research associate with Wong-Parodis research group.

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Which mask works? Researchers find confusion over mask use for wildfire, COVID-19 crises - Stanford University News

Immunology

The Immunology Drug market to be under the gambit of growth curve in the next decade – TechnoWeekly

The immune system is an assembly of structures and processes inside the body to protect against possibly damaging foreign bodies and diseases. It identifies various threats like bacteria, viruses, and parasites and distinguishes them from bodys healthy tissues. When the immune system weakness and lose the capability to detect and destroy the abnormal cells or body attacks and damages its tissues lead to diseases like cancer and autoimmune diseases. Immunotherapy is a process which includes the treatment by inducing, enhancing or suppressing an immune system to fight against the diseases.

For more insights into the Market, request a sample of this report @https://www.persistencemarketresearch.com/samples/15259

According to American Autoimmune Related Diseases Association, autoimmune disease affects up to 50 million Americans. Autoimmune diseases are of 80 types out of which most prevalent are rheumatoid arthritis, Systemic Lupus Erythematous (Lupus),Juvenile rheumatoid arthritis,inflammatory bowel arthritis, Psoriatic arthritis and affects different body organs like joints, muscles, skin, red blood cells, blood vessels, connective tissues and endocrine glands. Immunology drug is becoming the choice of several oncologists as they provide long-lasting affect by activating the immune system to identify cancerous cell and kill them through the natural process as well as improve the quality of survival. Some of the cancer treatment vaccines approved by FDA are bacillus Calmette-Gurin (BCG), Sipuleucel-T which propel the growth of the Immunology Drug market.

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Immunology Drug Market: Drivers and Restraints

The increase in the prevalence rate of the different type of cancer and rheumatoid cancer, rising government initiatives, increasing funding from the various government and non-government organization is driving the immunology drug market. Patients with poor prognosis are expected to drive the growth of the immunology drugtrial evidence reveals that after preparing the immune system to fight against cancer immunology, drug effects last for a long time even after the reduction of the tumor. High costs of immunology drug and lack of awareness could be the possible restraints for the immunology drug market. Also, the introduction of generic drugs in some regions and slower pipeline development are the challenges for the immunology drug market.

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Immunology Drug Market: Segmentation

Immunology drug market is segmented by drug class and the end users.

To the date most clinically and effective drugs in monoclonal antibodies are Humira (adalimumab) and Remicade (infliximab).

Immunology Drug Market: Overview

Development of some new drugs with success rate is expected to offer the good opportunity for immunology drug market. Wide-ranging scope of Immuno-oncology agents in different cancer treatments would provide the maximum share to immunology drug market in the forecast period. pharmaceutical companies and R&D are showing increased interest in this field and is expected to offer better potential for immunology drug market. Companies involved in partnership and R&D for efficient technologies are some of the latest trends that have been observed in immunology drug market. Currently, most of the immunology drugs are in clinical trial and are expected to rise the immunology market after clearance or success of these products from clinical trials.

Immunology Drug Market: Region-wise Outlook

North America has the largest share globally in immunology drug market because of the availability of better reimbursement policies, high potential to invest the huge amount of money in the development of immunology drug and the advancement in the technologies. Europe is the second largest region regarding value because of the easy accessibility to the immunology drug, and also the affordability for the cost of treatment is high. Increase in awareness, rising economy, increasing government initiatives and large patient pool in Asia-Pacific regions also demonstrates the higher growth in Immunology Drug Market.

Immunology Drug Market: Key Market Participants

Some of the major players in Immunology drug market are Abbott Laboratories, Active Biotech, Eli Lilly and Company, Autoimmune Inc., Pfizer, Inc., GlaxoSmithKline plc, Seattle Genetics, Inc., Genentech, Inc., F. Hoffmann-La Roche Ltd., Eisai Co., Bayer AG and Sanofi Aventis LLC.

The immune system is an assembly of structures and processes inside the body to protect against possibly damaging foreign bodies and diseases. It identifies various threats like bacteria, viruses, and parasites and distinguishes them from bodys healthy tissues. When the immune system weakness and lose the capability to detect and destroy the abnormal cells or body attacks and damages its tissues lead to diseases like cancer and autoimmune diseases. Immunotherapy is a process which includes the treatment by inducing, enhancing or suppressing an immune system to fight against the diseases.

According to American Autoimmune Related Diseases Association, autoimmune disease affects up to 50 million Americans. Autoimmune diseases are of 80 types out of which most prevalent are rheumatoid arthritis, Systemic Lupus Erythematous (Lupus),Juvenile rheumatoid arthritis,inflammatory bowel arthritis, Psoriatic arthritis and affects different body organs like joints, muscles, skin, red blood cells, blood vessels, connective tissues and endocrine glands. Immunology drug is becoming the choice of several oncologists as they provide long-lasting affect by activating the immune system to identify cancerous cell and kill them through the natural process as well as improve the quality of survival. Some of the cancer treatment vaccines approved by FDA are bacillus Calmette-Gurin (BCG), Sipuleucel-T which propel the growth of the Immunology Drug market.

Immunology Drug Market: Drivers and Restraints

The increase in the prevalence rate of the different type of cancer and rheumatoid cancer, rising government initiatives, increasing funding from the various government and non-government organization is driving the immunology drug market. Patients with poor prognosis are expected to drive the growth of the immunology drugtrial evidence reveals that after preparing the immune system to fight against cancer immunology, drug effects last for a long time even after the reduction of the tumor. High costs of immunology drug and lack of awareness could be the possible restraints for the immunology drug market. Also, the introduction of generic drugs in some regions and slower pipeline development are the challenges for the immunology drug market.

Immunology Drug Market: Segmentation

Immunology drug market is segmented by drug class and the end users.

To the date most clinically and effective drugs in monoclonal antibodies are Humira (adalimumab) and Remicade (infliximab).

Immunology Drug Market: Overview

Development of some new drugs with success rate is expected to offer the good opportunity for immunology drug market. Wide-ranging scope of Immuno-oncology agents in different cancer treatments would provide the maximum share to immunology drug market in the forecast period. pharmaceutical companies and R&D are showing increased interest in this field and is expected to offer better potential for immunology drug market. Companies involved in partnership and R&D for efficient technologies are some of the latest trends that have been observed in immunology drug market. Currently, most of the immunology drugs are in clinical trial and are expected to rise the immunology market after clearance or success of these products from clinical trials.

Immunology Drug Market: Region-wise Outlook

North America has the largest share globally in immunology drug market because of the availability of better reimbursement policies, high potential to invest the huge amount of money in the development of immunology drug and the advancement in the technologies. Europe is the second largest region regarding value because of the easy accessibility to the immunology drug, and also the affordability for the cost of treatment is high. Increase in awareness, rising economy, increasing government initiatives and large patient pool in Asia-Pacific regions also demonstrates the higher growth in Immunology Drug Market.

Immunology Drug Market: Key Market Participants

Some of the major players in Immunology drug market are Abbott Laboratories, Active Biotech, Eli Lilly and Company, Autoimmune Inc., Pfizer, Inc., GlaxoSmithKline plc, Seattle Genetics, Inc., Genentech, Inc., F. Hoffmann-La Roche Ltd., Eisai Co., Bayer AG and Sanofi Aventis LLC.

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The Immunology Drug market to be under the gambit of growth curve in the next decade - TechnoWeekly

Immunology

Looking at the efficacy of baked egg therapy at improving egg allergy outcomes – Contemporary Pediatrics

Oral immunotherapy has been an effective way to treat peanut and egg allergies. Can baked egg therapy improve food allergy outcomes in children who can tolerate baked eggs?

Eggs are one of the big 8 food allergens and much like with peanuts, using oral immunotherapy has been used to achieve desensitization and sustained unresponsiveness. An investigation in the Journal of Allergy and Clinical Immunology looked at the potential benefits of baked egg therapy for egg allergy, which the researchers noted had not been well studied previously.1

The researchers enrolled children aged 3 to 16 years who were baked egg-tolerant but unbaked egg reactive. Each participant was randomized to receive 2 years of treatment with either egg oral immunotherapy or baked egg therapy. They administered double-blind, placebo-controlled food challenges following 1 and 2 years of treatment to assess for desensitization. Another challenge was administered after 2 years of treatment, followed by 8 to 10 weeks without the treatment, to assess sustained unresponsiveness. Additionally, some children who were baked egg-reactive were given egg oralimmunotherapy and given identical double-blind, placebo-controlled food challenges to be used as a comparator group.

A total of 50 children were included in the study. The investigators found that sustained unresponsiveness occurred in 3 of the 27 children who were assigned to the baked egg therapy group versus 10 of the 23 participants who had been assigned to receive egg oral immunotherapy (P = .009). Within the comparator group, 7 of the 39 children were able to achieve sustained unresponsiveness. The dosing symptom frequency was similar for both baked egg therapy and egg oral immunotherapy among the children who were baked egg tolerant, but were more frequent in the comparator group. The investigators found that egg whitespecific immunoglobulin E skin testing and basophil activation decreased in a similar fashion following baked egg therapy and egg oral immunotherapy.

The researchers concluded that treatment of unbaked egg allergy with oral immunotherapy was much more likely to help a child achieve sustained unresponsiveness than baked egg therapy.

Reference

1. Kim E, Perry T, Wood R, et al. Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy. Journal of Allergy and Clinical Immunology. 2020;146(4):851-862.e10. doi:10.1016/j.jaci.2020.05.040

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Looking at the efficacy of baked egg therapy at improving egg allergy outcomes - Contemporary Pediatrics

Immunology

ETF Strategies to Tap into Medical Breakthroughs, Healthcare Innovations – ETF Trends

The election year and the coronavirus has highlighted the importance of an adaptive health industry that meets up with quickly changing times. Investors can also tap into this evolution in healthcare through targeted exchange traded fund strategies to capture this shifting opportunity.

The 2020 election has illuminated the growth potential within digital health, immunotherapy, and genomics that could be accelerated by the pandemic, Jeff Spiegel, Head of U.S. iShares Megatrend and International ETFs, said in a research note. For equity investors, the election offers a chance to reevaluate their healthcare exposure to help ensure that their positions reflect the most relevant, long-term themes and that their holdings do not fail to capture the potential cross-sector opportunities available with increased virtualization.

Looking ahead, the market for digital health technologies is expected to expand as more people shift toward virtual work and life due to the Covid-19 pandemic. Meanwhile, attitudes toward healthcare regulations continue to relax irrespective of the U.S. election outcome.

Sub-sectors like immunotherapy and genomics are quickly developing as the search for an effective COVID-19 treatment and vaccine accelerates the development of RNA therapeutics and personalized medicine.

We are also witnessing new developments in regulatory, technological, and scientific advancements that have produced innovations across the fields of telehealth, mobile healthcare applications, immunotherapy, and genomics. Consequently, Spiegel argued that investors might want to consider a megatrends approach, over a sector approach, that can offer broad, thematic exposure to multi-sector themes.

For example, theiShares Virtual Work and Life Multisector ETF (NYSE: IWFH) tracks the NYSE FactSet Global Virtual Work and Life Index, an index of developed and emerging market companies that provide products, services, and technologies that empower individuals to work remotely and support an increasingly virtual way of life.

The iShares Genomics Immunology and Healthcare ETF (IDNA) targets exposure to companies worldwide at the forefront of medical revolutions in the rapidly expanding fields of molecular biology and mapping of genomes, and immunology.

iShares Nasdaq Biotechnology ETF (IBB) has been a go-to play for broad biotechnology exposure. The ETF tracks the NASDAQ Biotechnology Index, which contains securities of companies listed on NASDAQ that are classified according to the Industry Classification Benchmark as either biotechnology or pharmaceuticals and that also meet other eligibility criteria determined by Nasdaq, Inc.

Lastly, the iShares U.S. Tech Breakthrough Multisector ETF (TECB) tries to reflect the performance of the NYSE FactSet U.S. Tech Breakthrough Index, which is composed of U.S. companies that could benefit from various breakthrough technologies, including robotics and artificial intelligence, cloud and data tech, cybersecurity, genomics and immunology, and financial technology.

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ETF Strategies to Tap into Medical Breakthroughs, Healthcare Innovations - ETF Trends

Immunology

Impact/Shock Recorders size and Key Trends in terms of volume and value 2020-2020 – Aerospace Journal

This report also researches and evaluates the impact of Covid-19 outbreak on the Impact/Shock Recorders industry, involving potential opportunity and challenges, drivers and risks. We present the impact assessment of Covid-19 effects on Impact/Shock Recorders and market growth forecast based on different scenario (optimistic, pessimistic, very optimistic, most likely etc.).

Global Impact/Shock Recorders Market Overview:

The research report, titled [Global Impact/Shock Recorders Market 2020 by Company, Regions, Type and Application, Forecast to 2025], presents a detailed analysis of the drivers and restraints impacting the overall market. Analysts have studied the key trends defining the trajectory of the market. The research report also includes an assessment of the achievements made by the players in the global Impact/Shock Recorders market so far. It also notes the key trends in the market that are likely to be lucrative. The research report aims to provide an unbiased and a comprehensive outlook of the global Impact/Shock Recorders market to the readers.

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Global Impact/Shock Recorders Market: Segmentation

For clearer understanding of the global Impact/Shock Recorders market, analysts have segmented the market. The segmentation has been done on the basis of application, technology, and users. Each segment has been further explained with the help of graphs figures. This breakdown of the market gives the readers an objective view of the global Impact/Shock Recorders market, which is essential to make sound investments.

Segment by Type, the Immunology Drug market is segmented intoMonoclonal Antibodies (mAb)Antibody Drug ConjugatesInterferon and Cytokine therapiesImmunosuppressive medication

Segment by Application, the Immunology Drug market is segmented intoHospitalsClinicsCancer Research Centers and Institutes

Regional and Country-level AnalysisThe Immunology Drug market is analysed and market size information is provided by regions (countries).The key regions covered in the Immunology Drug market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of sales and revenue for the period 2015-2026.

To understand the changing political scenario, analysts have regionally segmented the market. This gives an overview of the political and socio-economic status of the regions that is expected to impact the market dynamic.

Global Impact/Shock Recorders Market: Research Methodology

To begin with, the analysis has been put together using primary and secondary research methodologies. The information has been authenticated by market expert through valuable commentary. Research analysts have also conducted exhaustive interviews with market-relevant questions to collate this research report.

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Global Impact/Shock Recorders Market: Competitive Rivalry

The research report also studied the key players operating in the global Impact/Shock Recorders market. It has evaluated and elucidated the research and development statuses of these companies, their financial outlooks, and their expansion plans for the forecast period. In addition, the research report also includes the list of strategic initiatives that clearly explain the achievements of the companies in the recent past.

Competitive Landscape and Immunology Drug Market Share AnalysisImmunology Drug market competitive landscape provides details and data information by players. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on revenue (global and regional level) by players for the period 2015-2020. Details included are company description, major business, company total revenue and the sales, revenue generated in Immunology Drug business, the date to enter into the Immunology Drug market, Immunology Drug product introduction, recent developments, etc.The major vendors covered:Abbott LaboratoriesActive BiotechEli Lilly and CompanyAutoimmune Inc.PfizerGlaxoSmithKline plcSeattle GeneticsGenentechF. Hoffmann-La Roche Ltd.Eisai Co.Bayer AGSanofi Aventis LLC.

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Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Impact/Shock Recorders market

Chapter 2: Evaluating the leading manufacturers of the global Impact/Shock Recorders market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Impact/Shock Recorders market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

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Impact/Shock Recorders size and Key Trends in terms of volume and value 2020-2020 - Aerospace Journal

Immunology

Novartis fills manufacturing gap for CAR-T therapy Kymriah with first Asian production facility – FiercePharma

The blossoming field of cell and gene therapies has received a ton of interest from the world's largest drugmakers, but a common challenge plagues them all: How do you quickly and cheaply manufacture those therapies?

One strategy is going big. To boost manufacturing for cancer fighting CAR-TKymriah, Novartis is going global, and it nowhas the green light to produce the therapy at its first Asian production site.

Japanese regulators approved the commercial manufacturing of Kymriah at theFoundation for Biomedical Research and Innovation at Kobe, making it the first site in Asia toproduce the next-gen cancer-fighter for market, Novartissaid Friday.

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The Kobe site will add to Kymriah's global manufacturing footprint after Novartis plantedanother facilityand 450 new employeesin December to produce the therapy in Stein, Switzerland. Novartis also commercially manufactures Kymriah at its facilitiesin Morris Plains, New Jersey, and Les Ulis France, as well as at a contract manufacturing site at the Fraunhofer Institute for Cell Therapy and Immunology in Leipzig, Germany.

Novartis is also planning to make the therapy at Cell Therapies in Australia and Cellular Biomedicine Group in China, according to a release. The FDA recently approved an expansion at Novartis' Morris Plains site.

A Novartis spokeswoman didn't estimate how much capacity the Kobe site would add to Kymriah's footprint but noted the drugmaker has more than tripled its capacity over the past year.

RELATED:Novartis' new cell therapy facility could ease manufacturing squeeze for CAR-T med Kymriah

Novartis has looked to rapidly ramp up its geographic footprint for Kymriah as logistical challenges have hamstrung the pricey and difficult-to-make therapy's rollout.

In December, Novartis opened the Stein site specifically to manufacture tailored cell therapies for European patients, opening abottleneck that previously required two transatlantic flights to the drugmaker's sole facility in Morris Plains.

Kymriah initially received the FDA's go-ahead to treat lymphoblastic leukemia in August 2017, making it the first CAR-T approved on U.S. shores for any indication. Novartis followed that up with a Kymriah approval in B-cell lymphoma in May 2018 and is chasing a third indication in follicular lymphoma, where it may file for approval next year.

At time of opening in December, the Stein locationemployed 185 employees, many of whom previouslyworked at Novartis'"traditional chemical and pharmaceutical manufacturing"sites in Basel, Schweizerhalle and Stein. Novartis plannedto hike that workforce up to450 workers and make a $90.6 millioninvestment over three years.

RELATED:With cell and gene therapy boom coming, experts at Novartis, Kite trumpet need for capacity

With approvals for novel cell and gene therapies expected to tick up in the coming years, drugmakers are making huge down payments to overcome a projected manufacturing crunch.

Gilead Sciences, which produces Yescarta, the second CAR-T therapy approved in the U.S., has also been expanding rapidly, including opening a long-awaited117,000-square-foot plant at SEGRO Park Amsterdam Airport in June.

The newest facility is the"next step" in Gilead's global manufacturing ramp-up for Yescarta, according toChuck Calderaro, global head of technical operations for Gilead's Kite unit, as the site will be able to churn out enough of the pricey therapy for 4,000 patients each year.

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Novartis fills manufacturing gap for CAR-T therapy Kymriah with first Asian production facility - FiercePharma

Immunology

Correction to AbbVie Earnings Article – Morningstar.com

AbbVie Inc.'s third-quarter revenue from its immunology portfolio was $5.79 billion, a 14.8% increase year over year. That result included revenue from AbbVie's Humira medication of $5.14 billion, a figure that rose 4.1% year over year. "AbbVie Logs 3Q Sales Growth on Higher Immunology, Oncology Results," published at 8:22 a.m. ET, incorrectly said that immunology revenue increased 4.1%, to $5.14 billion.

(END) Dow Jones Newswires

October 30, 2020 09:50 ET (13:50 GMT)

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Correction to AbbVie Earnings Article - Morningstar.com

Biochemistry

Vanderbilt biochemists reveal the cause of Charcot-Marie-Tooth diseasetoo much of a good thing – Vanderbilt University News

Vanderbilt researchersincludingCharles Sanders, associate dean for research and professor of biochemistry, and graduate studentJustin Marinkohave illuminated the cause of Charcot-Marie-Tooth disease, putting them on the road to developing therapeutic approaches for the disease that affects one in 2,500 people.

The discovery was published in the article Direct Relationship Between Increased Expression andMistraffickingof the Charcot-Marie-Tooth-Associated Protein PMP22 published in theJournal of Biological Chemistryon July 9. The significance and overall importance of the findings within the article earned it the rare distinction of Editors Pick.

Charcot-Marie-Tooth disease is known to cause the peripheral nerves to stop working, causing loss of dexterity and the sense of touch in the hands and feet. Over two decades, Sanders has been studying a targeted approach to treat Charcot-Marie-Tooth disease and other neuropathies by looking at rarely examined proteins.

The lab shutdown brought on by COVID-19 afforded Marinko time to more deeply analyze data previously collected in the lab. Marinkos work with this data showed that overproduction of the membrane protein PMP22 is too much of a good thing; it turns individual cells into traps.

During the safer-at-home period, we started to think about our large dataset and the layers within that data that could be analyzed in ways that we had not previously considered, said Marinko, who also is winner of theAnne Karpay Award. A very positive outcome came as a result of having some time to think about the data more thoroughly.

In healthy cells, there are two copies of the gene encoding PMP22, a protein that snakes through the lipid bilayer of the cell several times until it reaches the cell surface. Under disease conditions, a third copy adds more PMP22 to the cell in a way that overloads its pathway to the exterior of the cell, leading to most of the protein getting trapped within the cellwhere it becomes toxic and disease-causing. This research is the first experimental evidence that definitively points to this mechanism as the cause of the most common form of Charcot-Marie-Tooth disease. A similar phenomenon likely occurs for other proteins in other disorders involving unregulated cell behavior, including some forms of cancer.

The investigation is the outcome of a continuing collaboration between the Sanders Lab and that ofBruce Carter, professor of biochemistry and an associate director of theVanderbilt Brain Institute.

Discovering this relatively new phenomenon was an important step and a highlight for our lab, said Sanders, also the Aileen M. Lange & Annie Mary Lyle Chair in Cardiovascular Research.I am thrilledabout the future of this workwith our friends in the Carter Lab, translating our data and model cell line work to nervous system cells.

The work was supported by NIH grants R01 NS095989 and R01 NS107456, NIH fellowship F31 NS113494 and NIH training grant T32 NS00749.

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Vanderbilt biochemists reveal the cause of Charcot-Marie-Tooth diseasetoo much of a good thing - Vanderbilt University News

Biochemistry

Biochemistry Analysers Market to Showcase Vigorous Demand During the Period until 2025 – The Think Curiouser

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Biochemistry Analysers Market to Showcase Vigorous Demand During the Period until 2025 - The Think Curiouser