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UCD Post-doctoral Research Fellow Level 1, School of Medicine job with UNIVERSITY COLLEGE DUBLIN (UCD) | 234707 – Times Higher Education (THE)

Applications are invited for a temporary post of a UCD Post-doctoral Research Fellow Level 1 within the UCD School of Medicine

University College Dublin is seeking applications for a Postdoctoral Research Fellow position to work on a collaborative research project in Precision Oncology Ireland (a Science Foundation Ireland Strategic Partnership Programme). The project is in collaboration with AstraZeneca.

Immune Checkpoint inhibitors (ICIs) have opened a new avenue for cancer therapy. However, responses are variable between different patients and cancer types. For instance, clinical studies of ICIs in epithelial ovarian cancer have yielded low response rates despite being an extremely antigenic tumour, with a very dynamic tumour microenvironment, The objective of this study is to work with AstraZeneca, systems biologists and clinician scientists to improve the efficacy of ICIs in low response cancers such as epithelial ovarian cancer - the most lethal form of female cancer.

The main aims of the project are to:

This project is carried out by an interdisciplinary team at Systems Biology Ireland (SBI) at UCD and AstraZeneca (Cambridge, UK). This post will be located at SBI and jointly supervised by Prof Walter Kolch (systems biology, proteomics) and Prof Donal Brennan (clinician, single cell sequencing). The position may also include opportunities to visit AstraZeneca. The ideal candidate will have a strong background in (onco)immunology and cell biology, a solid working knowledge of signal transduction and omics methods to analyse signalling processes.

This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator.

The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching.

Precision Oncology Ireland (POI; http://www.precisiononcology.ie) is a consortium of 5 Irish Universities, 6 Irish Charities, and 8 companies aiming to develop new diagnostics and therapeutics for the personalised treatment of cancer. The consortium is part-funded by Science Foundation Ireland under their Strategic Partnership Programme. The shared vision is to combine cutting-edge genomics, proteomics, metabolomics and imaging technologies integrated through computational analysis and modelling to generate molecular profiles that allow us to better understand cancer pathogenesis, progression and response to therapies. Bringing together experimental and computational advances combined through data integration is a key competitive advantage of the POI consortium. The results will be better diagnostics, personalised cancer therapies, and acceleration of cancer drug discovery and development.

Systems Biology Ireland (SBI, http://www.ucd.ie/sbi), established in 2009, has successfully developed an integrated mathematical modelling and experimental research programme focusing on the design of new diagnostic and therapeutic approaches to diseases, primarily cancer, based on a systems level, mechanistic understanding of cellular signal transduction networks. To accomplish these goals, SBI uses mathematical and computational modelling approaches in combination with cutting edge experimental technologies in genomics, transcriptomics, proteomics, advanced microscopy and flow cytometry as well as cell biology and molecular biology methods. SBI's expertise, particularly in the area of modelling in systems pharmacology and therapeutics, strategically position it at the crossroads between biology and medicine. The purpose-built SBI facility sits in the space between the UCD Conway Institute and the Health Sciences Centre (UCD Charles Institute of Dermatology and School of Medicine). It is physically linked to both buildings, providing access to existing technology platforms, educational and conference facilities and ideally placed to train allied healthcare professionals. The facility houses a multidisciplinary team of some 50 researchers including bioinformaticians

Salary: 38,631 - 41,025 per annumAppointment on the above range will be dependent on qualifications and experience

Closing date: 17:00hrs (local Irish time) on 27th November 2021

Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.

UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.

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UCD Post-doctoral Research Fellow Level 1, School of Medicine job with UNIVERSITY COLLEGE DUBLIN (UCD) | 234707 - Times Higher Education (THE)

A New Future Market Insights Study Analyses Growth of Incubator Analyzer Market in Light of the Global Corona Virus Outbreak – The Courier

Incubators are used to cultivate and preserve microbiological cells and microbiological cultures in scientific labs. The incubators maintain optimum humidity, temperature, and other states of affairs such as the carbon dioxide and oxygen content of the inside atmosphere. Incubators are essential for various experimental work in molecular biology, cell biology, and microbiology. Incubators are used to culture both eukaryotic cells as well as bacterial cells. Incubators are produced in a variety of sizes, from warm rooms to preserve and cultivate a large number of samples to bench-top models for small experiments.

The Incubator Analyzer is designed to examine and perform anticipatory maintenance on incubators as well as radiant warmers. Incubator analyzer simultaneously measures the airflow, sound, relative humidity, and also varied range of autonomous temperatures. It can be used with open infant warmers, closed as well as forced-convection incubators including air-controlled, transportable, and baby-controlled units.

For more insights into the Market, request a sample of thisreport@ https://www.futuremarketinsights.com/reports/sample/rep-gb-8997

Market Dynamics Global Incubator Analyzer Market

Infant incubation analysis and growth in incubation for hatching eggs are key driving factors

Incubators are most widely utilized in incubation of microbes as well as in the preservation of plant and animal cell lines. The growth in the field of microbiological research is increasing the requirement to maintain the perfect environmental conditions in the incubator, thereby supporting the demand for incubator analyzers, for measuring and managing the optimum incubator environment throughout the experiment.

Incubator analyzer also plays a vital role in the infant incubation for creating a healthy environment for infant care. A surging number of premature births demanding critical infant care will continue to generate the need for infant incubation. The incubator analyzer plays a crucial role here by recording the test results, creating and maintaining the right environment, recording every detail in long term testing and analyzing the complex test records. These are the key driving factors for incubator analyzer market. The increasing use of incubation for various purposes like infant incubation, microbiological incubation, egg-hatching, insects incubation, and others is giving rise to the demand of incubator analyzer in the market.

The advanced research facilities and high focus on inventions in the field of biology, are boosting the growth of incubator analyzers

Increasing research and development activities in the industries like biotechnology, clinical research, pharmaceutical, hospitals, and research laboratories are stimulating the growth of global incubator analyzer market. Furthermore, the presence of numerous incubator analyzers and intensifying application of incubators for hatching eggs, and incubating insects are driving the incubator analyzer market.

Introduction of neonatal incubator analyzer for a newborn infant suffering from particular disease or disorder further triggers the growth of incubator analyzer market. However, the high cost of incubators, as well as incubator analyzers and lack of awareness in developing countries, are some of the restraints for the growth of the incubator analyzer market.

Key Players- Global Incubator Analyzer Market

The market is centralized with a finite number of manufacturers and is mostly dominated by big players like FLUKE. Some of the key players operating in the incubator analyzer market worldwide are-

Regional Outlook- Global Incubator Analyzer Market

North America, the earliest adopter of technological advances, to represent a key market for incubator analyzer

North America has been a prominent consumer region of incubator analyzers, and in the forecast period, it is anticipated to remain dominant. Owing to high expenditure on healthcare sector and substantial investments in the biological and clinical research sector. Europe is also an important market for manufacturers of incubator analyzer as the region has been raising high demand for neonatal incubator analyzers over the recent past. Asia Pacific is estimated to witness significant growth in incubator analyzer market owing to strong presence of majority of manufacturers in the APEJ region along with booming hatching egg industry. The Middle East and Africa is expected to experience moderate growth in the incubator analyzer market in coming years.

The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, and inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators, and governing factors, along with market attractiveness as per segment. The report also maps the qualitative impact of various market factors on market segments and geographies.

The report covers exhaustive analysis on:

Regional analysis includes:

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Segmentation- Global Incubator Analyzer market

Global incubator analyzer market is segmented on the basis of product type, test type, and region.

Global Incubator Market by Modularity

Global Incubator Analyzer Market by Equipment Type

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A New Future Market Insights Study Analyses Growth of Incubator Analyzer Market in Light of the Global Corona Virus Outbreak - The Courier

Emergex Vaccines Raises US$11 million to Advance Pipeline of Synthetic T-Cell Vaccines for Infectious Diseases – GlobeNewswire

PRESS RELEASE

Emergex Vaccines Raises US$11 million to Advance Pipeline of Synthetic T-Cell Vaccines for Infectious Diseases

Abingdon, Oxon, UK, 18 November 2020 Emergex Vaccines Holding Limited (Emergex), a company tackling major global infectious disease threats through the development of synthetic set point vaccines which prime the T-cell immune response, today announces that it has raised $11 million in a funding round supported by new and existing investors. This round follows a successful $11 million Series A completed in January 2020.

The proceeds of this funding round will, among other things, enable Emergex to further advance and execute its vaccine development strategy, producing vaccine candidates for some of the worlds most threatening and virulent diseases such as COVID-19, Dengue Fever and pandemic flu.

Emergexs next generation vaccines have been designed to expand the bodys natural immune response by programing CD8+ T-cells to rapidly recognise and respond to pathogens. This approach is aimed at providing effective prevention of disease while eliminating the allergic, autoimmune or antibody mediated side effects associated with traditional vaccines. Emergexs vaccines are 100% synthetic - requiring no biology for manufacturing - thus having the potential to be rapidly produced and cost-effectively scaled. They are delivered through a microneedle system which allows for convenient administration and require no cold chain in storage or distribution.

Storme Moore-Thornicroft, co-founder and COO of Emergex, commented: The current COVID-19 pandemic, the ongoing threat of pandemic flu and the global challenge of Dengue Fever demonstrate the urgent need to rethink traditional approaches to vaccine development. This new funding round demonstrates our investors confidence in the Company to meet that need and belief that our unique technology can play a critical role, creating safe, effective vaccines that can be rapidly developed and deployed.

We welcome our new investors to the Company and appreciate the continued support of our existing investors and look forward to rapidly advancing the clinical development of our novel vaccine candidates.

- Ends -

For further information, please contact:

Phone: +44 (0) 1235 527589

Email: smt@emergexvaccines.com

Phone: +44 (0)20 3709 5700

Email: Emergex@consilium-comms.com

About Emergex

Emergex, a UK-based biotechnology company headquartered in Abingdon, UK, is pioneering the development of synthetic set point vaccines which prime the T-cell immune response to address some of the worlds most immediate health threats such as COVID-19, Dengue Fever, Zika, Ebola, pandemic flu and serious intra-cellular bacterial infections.

These set-point vaccines modify the initial immune status of recipients in a way that primes their immune systems to recognise subsequent infectious agents much like a natural infection would do, preventing an acute or severe manifestation of the disease.

Emergex combines validated technologies together with the very latest scientific insights to develop its vaccines, including using synthetic peptide codes determined on actual infected cells and using a proprietary gold nanoparticle carrier system for programming.

The Company has a growing pipeline of vaccine candidates. The most advanced development programme is a vaccine for Dengue Fever, which may also be disease modifying for other Flaviviruses such as the Zika and Yellow Fever viruses. Emergex also has programmes in development for a universal Influenza vaccine and a universal Filovirus vaccine (including viruses such as Ebola and Marburg) and discovery programmes for a Yellow Fever Booster vaccine and a Chikungunya vaccine.

Emergex has partnered with the Institute of Molecular and Cell Biology (IMCB) of Singapore to develop a vaccine for the emerging threat of Hand, Foot and Mouth (HFM) disease and has signed a Memorandum of Understanding (MoU) with Brazil-based Oswaldo Cruz Foundation Fiocruz for the development of viral vaccines. This initially covers the development of a vaccine that universally targets diseases within the flavivirus family such as Dengue Fever, Zika and Yellow Fever but could be expanded to include the development of vaccines to target other viral families that are endemic to the region.

Find out more online at http://www.emergexvaccines.com.

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Emergex Vaccines Raises US$11 million to Advance Pipeline of Synthetic T-Cell Vaccines for Infectious Diseases - GlobeNewswire

Novel Antioxidant Seen as an Effective Strategy for Peripheral Artery Disease – BioSpace

OMAHA, Ne., Nov.20, 2020 /PRNewswire/ -- Researchers within the School of Health and Kinesiology at the University of Nebraska at Omaha (UNO) have found that a novel antioxidant can provide a number of health benefits for individuals with peripheral artery disease.

The antioxidant specifically targets mitochondria, considered the powerhouse of the cell. The study was led by Assistant Professor Song-Young Park, Ph.D., and published in the American Journal of Physiology-Heart and Circulatory Physiology.

Park recruited eleven men and women with PAD to participate in this research; six of which received 80 milligrams of the antioxidant while the remaining five participants were given a placebo. Measurements were done before and 40 minutes after each participant took the supplement or placebo to assess the roles of vascular mitochondria in endothelial function, arterial stiffness, exercise tolerance and skeletal muscle function. After a 14 day "wash out" period, the two groups switched, with the placebo group taking the supplement and vice versa and measurements were assessed again.

When a participant took the supplement, the researchers noted an increase in dilation of the arteries, popliteal flow-mediated dilation, antioxidant superoxide dismutase, maximal walking time and distance, and time to claudication or leg pain.

"The results of this study reveal for the first time that acute oral intake of a mitochondrial-targeted antioxidant is effective for improving vascular endothelial function and superoxide dismutase in patients with peripheral artery disease (PAD)," Park said. "This improvement is clinically important and such antioxidants may potentially be utilized as therapeutic supplement for patients with PAD".

The antioxidant, commercially available as MitoQ, contains the naturally occurring ubiquinol which is a coenzyme that gives the antixoxidant the ability to cross the cell membrane and accumulate within the mitrochondria.

Peripheral artery disease (PAD) is a common cardiovascular disease in which atherosclerotic plaque forms in the arteries of the leg which can cause decrease blood flow and reduced perfusion in the lower extremity. The disease affects nearly 200 million people worldwide, with over 20 percent of individuals over 80 years old being affected by this disease. Common symptoms often include foot ulcers and leg pain during walking. If severe, medical treatment up to and including leg amputation may be required.

This study was funded in part by the University of Nebraska at Omaha Graduate Research and Creative Activity (GRACA) grant awarded to Jiwon Song, University of Nebraska at Omaha University Committee on Research and Creative Activity (UCRCA) awarded to Song-Young Park and the NASA Nebraska Space Grant (#NNX15AI09H) awarded to Song-Young Park. Doses of MitoQ were donated to UNO by MitoQ Limited for use in this research study.

About the University of Nebraska at Omaha

Located in one of America's best cities to live, work and learn, the University of Nebraska at Omaha (UNO) is Nebraska's premier metropolitan university. With more than 15,000 students enrolled in 200-plus programs of study, UNO is recognized nationally for its online education, graduate education, military friendliness and community engagement efforts. Founded in 1908, UNO has served learners of all backgrounds for more than 100 years and is dedicated to another century of excellence both in the classroom and in the community.

View original content:http://www.prnewswire.com/news-releases/novel-antioxidant-seen-as-an-effective-strategy-for-peripheral-artery-disease-301176579.html

SOURCE University of Nebraska at Omaha

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Novel Antioxidant Seen as an Effective Strategy for Peripheral Artery Disease - BioSpace

November: Highly cited 2020 | News and features – University of Bristol

The Highly Cited Researchers 2020 list recognises 17 University of Bristol researchers reaching the highest sphere of influence in research.

The citation analysis, now in its seventh year, identifies those who have published a high number of papers that rank in the top one per cent most cited works in their field. This year,6,389 researchers are named in theHighly Cited List.

The 17 researchers on the list (whose primary affiliation is with Bristol) this year are:Professor Jerry Nolan, Bristol Medical SchoolDr Jane Ferrie, Bristol Medical SchoolProfessor David Gunnell, Bristol Medical SchoolProfessor Matthew Hickman, Bristol Medical SchoolDr Jo House, School of Geographical SciencesProfessor Marcus Munafo, School of Psychological ScienceProfessor Kate Tilling, Bristol Medical SchoolProfessor Jonathan Bamber, School of Geographical SciencesProfessor Jules Hancox, School of Physiology, Pharmacology and NeuroscienceProfessor Eamonn Kelly, School of Physiology, Pharmacology and NeuroscienceDr Stephen Lolait, Bristol Medical SchoolProfessor Neil Marrion, School of Physiology, Pharmacology and NeuroscienceProfessor Craig McArdle, Bristol Medical SchoolProfessor Philip Donoghue, School of Earth SciencesProfessor Julian Higgins, Bristol Medical SchoolProfessor Deborah Lawlor, Bristol Medical SchoolProfessor Jonathan Sterne, Bristol Medical School

Placement on the list, which is based on qualitative and quantitative data from the Web of Science, is a significant achievement for those named.

Web of Science is the worlds most trusted and largest publisher-neutral citation index, powering global discovery and citation analytics across the sciences, social sciences and the arts and humanities. With over 1.4 billion cited references going back to 1900 and millions of users per day from leading government and academic institutions and research-intensive corporations the Web of Science citation network serves as the foundation for the Journal Impact Factor, InCites and other powerful and trusted citation-impact measures. The Web of Science helps researchers, research institutions, publishers and funders discover and assess the citation impact of over a century of research publications found in the most prestigious books, conference proceedings and journals.

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November: Highly cited 2020 | News and features - University of Bristol

Never Underestimate The Power Of Saying ‘I Like You Just The Way You Are’ – WBUR

There is no shortage of thoughts about President Donald Trumps supporters. Comments abound. They are ignorant, immoral, climate change deniers, racists, misogynists, religious fanatics, deplorables, and on and on.

Much of what is being said is silly. Or worse, it groups 74 million people into one big polluting lump of coal, making the behavior of the most extreme represent everyone. We blue folks can be pretty othering when we set ourselves to it, and we are good at the quiet sneer. Were enlightened theyre the unwashed masses. We get structural racism, climate change, gun control, science, and the real price of wealth inequality they dont. Were good. Theyre bad.

Wouldnt it be nice to think so. Ive worked for decades as a psychotherapist, and I am reminded each day what a mistake it is to assume that rational thought has the upper hand over our unconscious minds. However different our ideas about government, I believe the polarization and intense anger Red and Blue folks share springs from the unconscious wish each person possesses to feel that they are good enough just as they are.

In fact, were I to wager one vast generalization about many of the more fervent Trump voters, it would be that they experience him as their Mr. Rogers. You know, the man who so repeatedly and convincingly said, I like you just the way you are.

I understand that these two men seem like polar opposites, but its exactly that gulf that makes the comparison true. Trump is the anti-Rogers who likes his followers just the way they are.

Trump is completely unapologetic about every single aspect of his being: what he says, what he does, how often he lies, what he eats, how he cheats, who he hurts and on and on. And so they can be completely unapologetic, too.

Trump's supporters adore him because by insisting that a broad range of human behaviors are acceptable, he makes them feel understood, and not ashamed.

While humans have a capacity for love and for compassion, we have a whole host of not so pretty traits, too violence, greed, selfishness, cruelty and this president isnt having anything to do with the thick frosting of respectability that attempts to make the human cake all shiny and sweet.

He knows ugly, and he says ugly is nothing to be ashamed of. Its just part of who we are. In turn, Trump's supporters adore him because by insisting that a broad range of human behaviors are acceptable, he makes them feel understood, and not ashamed. They feel that he spares them their dignity (even if, in others' view, he's shredding every bit of decency, and deeply harming society).

That notion can be a huge relief. Especially to people who are being pushed to change in ways that seem abstract and mostly just make them feel bad about themselves and misunderstood, and like theyre being chastised, told theyre bad and that their sacrifices are meaningless.

When I think of the small, rural towns I grew up in, in Oregon and then in Vermont, normal meant occasionally enjoying being mean; making fun of peoples differences, forming cliques, bullying. We sometimes called each other ugly names, we told awful sexist and ethnic jokes. As girls, we all knew we were less than.

When, as a 22-year-old in 1974, I worked in a huge working-class daycare center in Lowell, Mass. my female boss called me The Jew when she was irritated with me, and The Wop when she wasnt. (I was both.) Other staff members included the The Polack, the Cannuck and the Mick. We all laughed a lot, not thinking much of it, but the tone was nasty.

Whats acceptable to do, or be, or say aloud, even to believe in private, has changed radically in half a century.

I worked for many of those changes, and heartily applaud the bulk of them. I passionately favor racial equality, gender equality, and on and on. But the changes have been accompanied by an unintentional oozing sense of superiority in those of us who have bought into this newer vision of whats OK and whats not.Weve seen the light. But the unspoken rest of that assumption is, We are virtuous and You are inferior, you are shameful.

[T]he changes have been accompanied by an unintentional oozing sense of superiority in those of us who have bought in to this newer vision of whats OK and whats not.

Wittingly or not, we often strip the dignity from anyone not in our club. We forget that theres a difference between feeling your vision of the world has something better to offer humanity, and feeling you are superior because you hold that vision. But the heat of the battle tends often to melt that distinction.

Part of Trumps genius has been to say, No, youre not less than to me. You are good people. I embrace you just the way you are. If you vote for me, I will have your back. I wont let anyone make you feel bad or ashamed even when you behave indecently. I do that too. The power of the message, however disingenuous the speaker, is profound.

The question facing those of us intent on creating greater racial, gender and economic equality, and on fueling a full-throttle effort to reverse climate change, is how we move forward legislatively, how we gather power and use it forcefully, without dehumanizing, devaluing or patronizing those who may disagree.

I dont know. It may be that the best our minds' hardwiring will let us do is move the othering from one place to another, and that ever rearranging groups will make meaning only by battling forever. Im not sure we can find another way. But its certainly a burning question. And were he still with us, I think Mr. Rogers would be all in on seeking an answer.

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Never Underestimate The Power Of Saying 'I Like You Just The Way You Are' - WBUR

Op-Ed: Let’s Not Lecture Healthcare Workers This Thanksgiving – MedPage Today

I read with interest the recent MedPage Today article "Demanding Thanksgiving Abstinence is Not Public Health." In it, Vinay Prasad, MD, MPH, argues that as public health officials, we should not be admonishing Americans to avoid Thanksgiving altogether during this COVID-19 resurgence. We should be more compassionate, he says, understanding that people are human beings with needs, and that many are going to do Thanksgiving the way they want to anyway. And knowing this, we should figure out how to listen to what people are telling us and work with them on ways to reduce risk without torpedoing their basic need for holiday connectedness after a long year of isolation.

This is our classic "harm reduction" approach, which is adapted from public health work with people who struggle with substance abuse, and reflects "a set of practical strategies and ideas aimed at reducing negative consequences associated with drug use," or in this case, not adopting behaviors that increase the risk of COVID-19. Harm reduction is also defined as "a movement for social justice built on a belief in, and respect for, the rights of people who use drugs."

I agree with the harm reduction approaches for this ongoing pandemic proposed by Dr. Prasad and others, as shaming people into behavioral submission to prevent spread of the novel coronavirus isn't the answer. Where I differ is that there is indeed even more nuance to this topic than the article suggests.

First, when we say that telling people to avoid Thanksgiving is an "abstinence-only" approach, we are automatically creating parallels to historical and current public health language and approaches with substance abuse, teen pregnancy, and the HIV epidemic. In these examples, abstinence-only speaks to people simply avoiding behavior that can lead to untoward consequences such as IV drug use or sex.

While there are parallels here to Thanksgiving, in general principle abstaining from substance abuse or certain sexual behaviors embodies a lifestyle change, not a skipping of a one-time holiday that, to be honest, is a luxury, not a necessity. Moreover, just stopping a behavior may be achievable for some, but not for others, so more realistic options must be offered.

Second, since we are using language from public health approaches with substance abuse and the HIV epidemic, it is useful to refresh our memories as to what actually happened back then. During the early 1980s when HIV first began to emerge, we knew that condoms worked, but to be honest, not everyone liked using them and/or could get access to them. Additionally, we didn't have any medications or effective treatments for HIV, so people were dying in droves. We didn't even have the prospect of a vaccine on the horizon to look forward to -- and still don't 40 years later.

While flying by the seat of our pants trying to handle the HIV epidemic that was decimating white gay communities, people who used IV drugs, and in Black and Latin communities, we sometimes encouraged drastic measures like telling people to avoid sex and IV drug use altogether.

The public health messaging was often judgmental and laced with stigma, but one could argue that we were in a crisis situation at the time and needed to do what was needed for the health of our communities while we waited on our government to even acknowledge that HIV existed and that treatments could be developed. Sound familiar?

Back then, I remember people being scared -- even without the public health messaging. I recall this because I was petrified as well. We didn't need a doctor or public health official to tell us how serious HIV was, as we saw it every week in the obituaries or when a friend suddenly didn't show up for a social gathering. People were here one day and gone the next.

Many were reluctant to have sex back then, even with condoms, while others listened to scientists and that, combined with what they were seeing on the ground, was enough to encourage additional precautions.

We live in different times now. There is a campaign to discredit science, facts, and truth. Healthcare workers who risk their lives daily to treat people with COVID-19 are being smeared in political and media outlets as greedy people just out to make a buck off the pandemic. Many are burned out, have become sick, and/or died from the virus, and some have suffered such tremendous mental health trauma from witnessing death on a daily basis that they have resorted to taking their own lives.

So as a medical community, we should give our colleagues a little wiggle room for knee-jerk reactions to social media clickbait when hearing about people not taking this pandemic as seriously as we know it is.

Truth is, we don't have comparable harm reduction tools for COVID-19 -- like needle exchange programs for IV drug use and pre-exposure prophylaxis for HIV prevention. Until the vaccine arrives, which may be months away, all we have in our toolkit are masks, handwashing, and physical distancing. That's all we got.

You'll have to excuse many medical and public health professionals if they resort to endorsing "abstinence-only" COVID-19 prevention approaches as a temporary solution for holiday gatherings. They are not trying to imprison anyone by suggesting they skip Thanksgiving this year -- they are merely trying to save lives and salvage what little is left of their physical and mental health in the process.

Finally, public health is indeed a service industry in that its primary purpose is to serve our communities. However, the fundamental flaw in declaring it a service industry like Walmart or Target, is that we are charged with the ethical responsibility of trying to educate and empower people beyond thinking only for themselves and their families when it comes to epidemics and disease states, as well as challenging them to understand how their behaviors may affect others as well.

This is the basic distinction between one-on-one clinical encounters and public health. The former simply focuses on what's best for the patient, while the latter considers both the patient and our larger communities. It's a formidable task when living in a country that thrives on and rewards narcissistic behavior like a prize won at a county fair.

There is no "right" way for public health officials to respond to this never-seen-in-our-lives-before pandemic. There is just a continuum of options that may be employed that should be patient-centered and appreciate human behavior and the desire for connectedness that COVID-19 has discarded like proverbial trash.

This is especially true when treatments for the virus are both expensive and limited, and the vaccine may be months away from reaching a general population that so desperately needs it.

While avoiding Thanksgiving altogether may not be the flavor for everyone's public health palate, given the circumstances and urgency of this situation where many still are not wearing masks or maintaining distance by choice, it may not be too unreasonable as a short-term suggestion.

Our job as public health officials shouldn't be to avoid "abstinence-only" speak altogether, but rather to figure out how to better communicate this as a temporary strategy so that our families, friends, and communities may consider it without shame, stigma, or feelings of coercion.

It may not be fruitful to lecture communities on how to react to this pandemic, but it is equally unproductive to lecture healthcare workers on how to react as well. We are all going through this together.

David Malebranche, MD, MPH, is a board-certified internal medicine, HIV, and sexual health physician who resides in Atlanta.

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Op-Ed: Let's Not Lecture Healthcare Workers This Thanksgiving - MedPage Today

Ways your Healthcare Company is Breaking the Law Without Realizing it – MedPage Today

According to the U.S. Department of Health & Human Services' Breach Portal, sometimes called the "Wall of Shame," 418 breaches of HIPAA were reported in 2019. Some 34.9 million Americans had their protected health information (PHI) compromised. How is this still happening?

Healthcare companies and practices make the biggest mistake by believing human behavior can be perfect all the time. For example, the employee may not have their encrypted work phone with them, so they choose to use their personal phone to send patient information. Email had the worst breaches ever in 2019.

Also resulting from this assumption about human behavior, healthcare providers cheap out and refuse to pay for sufficient security measures for their network. A cheap security system may not contain proper firewalls and leave devices vulnerable, while wholly unencrypted devices can be a nightmare. Healthcare employees leave their cell phones, laptops, or iPads in their vehicles while they run out for coffee or to the grocery. And what happens next? The vehicles are broken into, and PHI is at risk.

Several occurrences of this type took place involving employees at the Dallas Children's Hospital. An unencrypted, non-password protected Blackberry was lost at the DFW airport in November 2009, and Children's reported the breach to the Office of Civil Rights (OCR) in January 2010. It contained the electronic PHI of 3,800 patients.

Later, an unencrypted laptop was stolen from Children's in April 2013, containing electronic PHI of 2,462 patients. However, the hospital failed to report the theft. The OCR fined Children's $3.2 million for HIPAA noncompliance on these two data breaches.

This brings up another big tip: The OCR will be much more forgiving to those who report their own breach events, rather than being found out or reported by someone outside the organization.

Even then, Dallas Children's Hospital, which is part of Children's Health, the seventh-largest pediatric healthcare provider in the U.S., did not take encryption seriously and continued to issue unencrypted Blackberries and laptops to employees until 2013, despite being notified about the necessity for encryption back in 2007.

In addition, companies need to reinforce a "minimum information necessary" motto with their employees. Employees only need to access the patient information and medical history necessary for treatment or for payment. Snooping -- just simply being nosy -- can qualify as a violation and can lead to major fines. The world witnessed this when a UCLA Health System researcher went to jail for reading 323 confidential records held by the university's school of medicine, which contained medical records of various California celebrities.

Another common mistake is when paper PHI is disposed of incorrectly. Making sure medical records are shredded is of extreme importance. In Montgomery, Alabama, records were discovered in a garbage truck and all over the ground around the truck. They included names, numbers, x-rays, ultrasound, MRIs, and were clearly labeled "Radiology Department, Baptist Medical Center."

Here are a couple other tips to protect patients' privacy:

The easiest of slip-ups in HIPAA compliance come from conversational violations or "loose lips." A common example of this is when doctors and nurses talk about a patient at the coffee bar, elevator, or in the hallways with others around. Believe it or not, it happens all the time.

One alarming example of this was in a medium-sized hospital. There were many patients around, and the doctors and nurses were holding private conversations. An associate chief medical officer said, "Maybe we should open up the death rooms!" When asked what that was, he responded, "We only use them to talk away from the gathering family members whose loved one is about to die." Protected health information comes in all forms, positive and negative. I advised him to open the rooms for all conversations involving PHI, including if someone was cured of cancer. That is private information too!

While it may be fun to create this rapport or engage in such jocularity at work, non-compliant verbiage can become a very expensive joke.

These aspects cover the waterfront for HIPAA's privacy and security rules, but it is best for every healthcare provider to have at least one in-house compliance person. Said compliance professionals should attend webinars to keep themselves constantly informed as to how providers are being breached and save their employers millions of dollars in fines born of carelessness.

Concomitantly, healthcare CEOs must develop up-to-date strict policies and mandatory compliance training quarterly. It is also recommended to prohibit access to work emails, communications, and attachments using personal cellphones.

David Silva, CHC, CPHQ, is a healthcare compliance and quality professional with over 15 years of experience in leading teams in investigations, assessments, corrective action plan creation, and validation audits.

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Ways your Healthcare Company is Breaking the Law Without Realizing it - MedPage Today

How safe is it to go to indoor movie theaters during the COVID-19 pandemic? – Gazettextra

Remember what it was like going out to see a movie?

Even though movie theaters have implemented protocols to protect guests and staff during the COVID-19 pandemic, and many of the measures have been met with praise from experts, the exhibition industry remains in a state of crisis. Indoor theaters have been closed in Los Angeles County since mid-March, and Gov. Gavin Newsom pulled the "emergency brake" on the rest of the state last week, shutting down many indoor businesses in California, including most movie theaters. Even when these restrictions lift, the industry will be anxious to reopen safely.

And in many other states, the question remains: With the national totals surpassing 12 million infections, more than 255,000 Americans dead and daily numbers surging to record highs, just how risky is it to see a movie indoors?

The argument from the exhibition industry to keep theaters open relies on confidence in the COVID-19 protocols theaters are putting in place including mask mandates, enhanced cleaning, automatic seating gaps between parties, limited auditorium capacity, staggered showtimes and other measures. They say no outbreaks have yet been traced back to movie attendance.

"That's not just (in) the U.S. but anywhere in the world," said Patrick Corcoran, vice president and chief communications officer of the National Assn. of Theater Owners, which introduced the "CinemaSafe" program that theaters can opt into. "There have been people who have worked at movie theaters or who have attended movie theaters who have had it, but it hasn't been passed on to others in that environment through any tracing."

"The guidance looks great on paper," said Dr. Peter Chin-Hong, an infectious disease specialist at UC San Francisco. "If you have a well-ventilated movie theater and people keep their masks on for the whole time and they are socially distant, and you don't go to the movies when you're sick ... it's probably going to be a relatively safe environment."

However, he notes those protocols can easily be defeated by the actions of others. "You can have a lot of recommendations, but at the end of the day, it's really human behavior."

And while Chin-Hong agrees there are "no documented COVID cases linked to movie attendance to date globally," he adds, "the absence of an association does not mean that there have not been any transmissions."

To help unpack this debate, The Times spoke with two industry spokespeople Corcoran and Chanda Brashears, vice president of investor relations and public relations of Cinemark Theaters; and three public health experts Chin-Hong, Dr. Georges Benjamin, executive director of the American Public Health Assn. and Dr. Annabelle De St. Maurice of UCLA.

The experts praised many of the industry's safety measures right up to the point of entering the auditorium. Once inside, though, the hazards increase, they agreed, mostly because of choices patrons make.

Mask mandates

Everyone interviewed for this article agreed mask wearing was key. CinemaSafe guidelines state, however, "face coverings may be removed for the limited purpose and limited time period necessary to consume food and beverages, if approved by state or local health authorities."

Benjamin, an internal medicine specialist and Maryland's former secretary of health, said, "Just like in a restaurant, you take a mask off to eat popcorn or drink, etc. And of course, when you do that, if you're infected, you will expel virus." Especially, he noted, if you laugh or scream at the movie.

De St. Maurice, a physician who specializes in pediatrics and infectious disease and is the co-chief infection prevention officer for UCLA Health, agreed, "How often are they going to pull the mask back up? And movies make you laugh and shout."

The health experts expressed concern that even proper social distancing might not be enough protection for a long period of exposure (say an average visit of two hours) to people who are not wearing masks. Benjamin invoked the CDC's definition of "community-related exposure" to infected individuals, even asymptomatic ones: "within six feet for a total of 15 minutes or more." In such cases, the CDC recommends those exposed "stay home until 14 days after last exposure," entering quarantine protocols.

"The activity within a movie theater is very different from what you have at a bar or a restaurant," Corcoran countered. "You don't have people facing each other." The duration of attendance helps mitigate risk, he added, as opposed to in a restaurant or bar, where "people finish eating, and they get up and leave, (replaced by) more people."

Cinemark has added employees whose sole job it is to make sure staff and patrons are following COVID-19 rules, Brashears said.

Still, De St. Maurice noted, enforcement could be an issue: "You may get pushback and a lot of these employees are teenagers and may not feel comfortable correcting an adult. You want to keep the theater open, and you want to keep your customers happy."

Seating and social distancingSocial distancing is defined by the CDC as maintaining six feet from people not in your household. Theaters have tried to enforce this by reducing crowds with staggered showtimes, fewer choices at concession stands, etc. AMC and Cinemark are among those that have instituted ticket-buying systems that automatically insert a one-seat buffer on either side of parties for a total of two seats separating parties from others. However, if most cinema seats are about two feet wide, that's only about a four-foot buffer.

Brashears said most of Cinemark's seats are wider-than-normal "recliners" and "rockers," so two adjacent would meet the six-foot standard.

Some auditoriums are laid out in a "stadium seating" configuration, in which rows are elevated as they progress backward.

"I think the other challenge is the stadium seating," said De St. Maurice. "You're coughing and there's droplets. Where are they going to land? Below you."

Corcoran noted that stadium seating starts with a greater distance between heads, in part because of the incline: "That distance is probably sufficient."

Ventilation

The chains tout their ventilation systems, including MERV 13 filters being installed in auditoriums. However, data wasn't available about the rate of air exchanges (the number of times per hour a ventilation system can replace the air in a room with new air from outside), which experts say matters most.

"It sounds like they've installed some MERV 13 filters in some areas, but I think without improving your air exchanges. And those filters are really expensive," De St. Maurice said, wondering if they're in every auditorium. "Optimizing air exchanges would be helpful. Opening doors so that you can get some outdoor air.

"If you think about it, if one person is sick and air just keeps recirculating, then you get into trouble. There was a restaurant in China, in Guangzhou, where the air was recirculating and (droplets) had spread more than six feet because the air basically just kept going in this loop. People who were sitting within that loop but maybe farther than six feet from the index case became infected as a result."

Brashears said, "In Cinemark theaters, the air comes straight down and then out through the side vents. We're bringing in a consistent flow of outside air, because we recognize how important that is." She also pointed out Cinemark's emphasis on "elimination of pollutants using MERV filters and integrating bipolar ionization."

Reducing crowds

The experts uniformly praised the exhibitors' masked employees, limited capacity, staggered showtimes, removal of shared condiments, cashless transactions and reduced menus.

"It's not about the menu," explained De St. Maurice. "It's about theoretically having fewer people waiting in line trying to decide what to get. Having a sign posted that says 'Don't wait in a line' isn't quite as effective as structuring things so that people are less inclined to wait in the line or really don't have to."

Off-peak hours are likely safer as well, Benjamin added. "Obviously, if they clean it real well at night, you're probably better off in the morning. You're probably better off when you have less people in the theater."

Local conditions and other concerns

All three health experts said extra caution should be exercised where infection positivity rates are higher, because any public activities would be more dangerous.

De St. Maurice said, "Whatever we can do to reduce transmission within the community is really important to keep these luxuries in our lives and allow those who are working in these industries to be able to work again."

An optimal movie theater scenario would include no concessions being sold and would have flexible schedules for workers and "good sick leave policies," De St. Maurice said, "so they could stay home when feeling ill, rather than being incentivized to work through it."

And while the experts were bullish on many of the steps taken, they were bearish on others taking patrons' temperatures, enhanced cleaning and wearing gloves, for instance. Benjamin pointed out gloves can transport contaminants just as well as bare skin can and if improperly used, can create a false sense of security. He also cited studies indicating the risk of fomite transmission (infection via touching surfaces) to be low.

Chin-Hong said, "People need to be flexible because things may change. The science is only as good as if people adhere to what's going on. Just like with a playground, you can have the guidance, but if you have a screaming child running by you ... you can't always control that environment, and I think that (the) unknown is what is probably most anxiety provoking about all of this."

So how safe is going to an indoor movie?

For perspective, The Times asked experts to rate the safety of certain activities on a scale from 0-100, 0 being the least likely to result in COVID-19 infection and 100 being the most dangerous. Among the activities listed, they separately agreed indoor moviegoing was among the riskiest. Benjamin declined to provide ratings but put moviegoing in the range of going to an indoor restaurant.

Outdoor restaurant: 10

Grocery store: 15-20 (or 30-40 if people congregate)

Commercial airliner: 40-50

Outdoor event, not socially distanced, masks not enforced: 40-50

Indoor movie: 50-60 (up to 75 if people are laughing, shouting, singing along)

Indoor bar, masks and social distancing not enforced: 80

As of this writing, the CDC lists moviegoing among its higher risk activities.

One solution that seems to address most of the experts' concerns, however, is the "Private Watch Party." In that option, up to 20 patrons can buy out a theater for a screening for $99-$149 (at Cinemark), eliminating the wild card of strangers' behavior within the auditorium. Brashears said the chain had sold upward of 50,000 of the events.

"At the end of the day, it all comes down to the consumer. Consumers have to play a part for us to operate safely," she said.

Corcoran recommended patrons visit the websites of the theaters they want to attend, to educate themselves on the specific protocols in place.

Chin-Hong said, "Being proactive rather than reactive is probably the best summary statement, but it not only depends on where you are, but who you are, how you determine what risk is. Maybe you're older or you have medical (concerns); you may decide the juice isn't worth the squeeze."

(c)2020 Los Angeles Times

Distributed by Tribune Content Agency, LLC

PHOTO (for help with images, contact 312-222-4194):

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How safe is it to go to indoor movie theaters during the COVID-19 pandemic? - Gazettextra

Malcolm Gladwell and his tipping point – The Jakarta Post – Jakarta Post

While some people take things in life as facts or accept a because its so explanation of matters like unconscious bias when meeting new people or the reasoning behind spur-of-the-moment decisions, author and journalist Malcolm Gladwell seeks to unravel the mysteries behind the ordinary.

In his best-selling debut bookThe Tipping Point, he examined the so-called tipping point in various formats like how patient zero can lead to a global pandemic or how even one person can jumpstart a trend, in a more benign example.

In the book, he outlined three factors or agents of change: The Law of the Few or the Pareto principle, where 80 percent of consequences are caused by 20 percent of the causes; The Stickiness Factor, where the specific content of a message can provide a memorable impact; and The Power of Context, which stipulates that human behavior is always context-sensitive to the environment.

When it was published in 2000,The Tipping Pointresonated greatly with readers, and the book sold millions of copies, landing it a place on theNew York Times bestsellers list and resulting in it being named one of the 21stcenturys 100 best books byThe Guardianin 2019.

Other books by Gladwell also explore oft overlooked themes, like decision making (Blink,2005), high achievers (Outliers,2008), underdogs (David and Goliath, 2013), and dealing with the unknown (Talking to Strangers,2019).

With his flair for mixing anecdotes and research notes, its no wonder that Gladwell was named as one of the 100 Most Influential People byTIMEin 2005 and was even considered again in 2011.

When asked what exactly drives him to take a closer look at these issues, the Canadian said he was curious by nature and enjoyed looking at things from unusual perspectives.

Once Ive written something, I never go back and reread it. Once Im finished with it, Ive lost interest in it and Im on to the next thing. So maybe theres something in my restlessness that keeps me inspired, he said in an interview on the heels of IDEAFest attended byThe Jakarta Post.

However, he also observed that many people, as they grow older, tend to lose their appetite for new things even as they gain new experiences along the way.

Gladwell said he tries his best to expose himself to new ideas and new people, as he does not wish to become stale, in the way he thinks some older journalists and writers are.

Even the age-old obstacle of writers block is a non-issue for him, something he attributed to his early days working at a newspaper.

I had to write nearly every day, and that cured me of any writers block. You cant be a newspaper reporter if you have writers block. I think its impossible, right?

The writing was not the hard part, he said. Instead, it was the thinking that came before the writing process, such as establishing the topic, researching, finding sources and so on.

By the time it comes to writing, I feel like all the hard work has been done, and then Im just putting things on the page. Its the preparation for writing thats the challenge.

Recipe for success: Malcolm Gladwell, the author of five 'New York Times' bestsellers, finds himself enjoying looking at things both overlooked and misunderstood. (Courtesy of gladwellbooks.com/epost-robot)

When the topic inevitably turned to the current pandemic after all,he did say inThe Tipping Pointthat ideas, messages and behaviors spread like viruses do Gladwell took a rather diplomatic approach in saying that the handling was not as good as expected.

But at the same time, its a really difficult problem for us, dealing with a contagious disease particularly one where we dont have a good understanding of who its going to affect the worst, how it spreads, how to treat it, Gladwell said.

If COVID was something that struck every fall and we were in the tenth year of COVID, we would be responding in a very different way. Weve never had this in this form before.

He also noted previous pandemics like the influenza pandemic of the late 1950s and the 1918 Spanish flu, but said there were few who could remember those times, which highlighted the needs for society to practice dealing with challenges like COVID-19.

He said he was not surprised that it had been difficult, for democratic countries in particular, to make sure everyone behaved appropriately.

I expect by the time this happens again and it will happen again well do a much better job.

As sheltering in place has been made mandatory in a wide variety of locations, Gladwell said that his productivity had increased, but at the same time, he missed many things that traveling offered.

Think about all the things Ive missed. Ive never been to Indonesia before. I would have met you all in person. I would have experienced its culture for the first time. There are a thousand unexpected experiences I would have had that Ill never have now, he said.

So I really do think that although I have more time for myself, the cost of the pandemic is much greater than the benefit for someone like me. Im someone who, for my work, needs to be exposed to new ideas, new people and new cultures. Thats being denied to me.

Traveling, he said, offered the chance to meet people and find ways they were similar and dissimilar to himself.

I feel like every culture in the world has something to teach us. We dont know in advance what that is. Thats why you travel, Gladwell said.

If I knew in advance what I would learn from going to Indonesia, I would just read a book. You pick up something different every time you experience something, so my mind would be entirely open to what I would learn. (ste)

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Malcolm Gladwell and his tipping point - The Jakarta Post - Jakarta Post