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Anatomy

Another familiar face returns to ‘Grey’s Anatomy’ – CNN

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CNN's u003ca href="https://www.cnn.com/profiles/jeanne-moos-profile" target="_blank">Jeanne Moosu003c/a> reports.","descriptionText":"Internet falls for Satan meeting his match on dating website. CNN's u003ca href="https://www.cnn.com/profiles/jeanne-moos-profile" target="_blank">Jeanne Moosu003c/a> reports."},{"title":"Canadian premier makes a critical holiday plea","duration":"01:38","sourceName":"CNN","sourceLink":"https://www.cnn.com","videoCMSUrl":"/video/data/3.0/video/health/2020/12/04/manitoba-canada-brian-pallister-christmas-coronavirus-sot-vpx.cnn/index.xml","videoId":"health/2020/12/04/manitoba-canada-brian-pallister-christmas-coronavirus-sot-vpx.cnn","videoImage":"//cdn.cnn.com/cnnnext/dam/assets/201204151627-brian-pallister-manitoba-canada-large-169.jpg","videoUrl":"/videos/health/2020/12/04/manitoba-canada-brian-pallister-christmas-coronavirus-sot-vpx.cnn/video/playlists/atv-trending-videos/","description":"As coronavirus cases rise, Manitoba Premier Brian Pallister issued an impassioned plea to his constituents, urging them to refrain from gathering over the upcoming Christmas holiday.","descriptionText":"As coronavirus cases rise, Manitoba Premier Brian Pallister issued an impassioned plea to his constituents, urging them to refrain from gathering over the upcoming Christmas holiday."},{"title":"Hikers discover new mystery monolith in California","duration":"01:41","sourceName":"CNN","sourceLink":"https://www.cnn.com/","videoCMSUrl":"/video/data/3.0/video/style/2020/12/03/california-monolith-mystery-pine-mountain-orig-vsop-bdk.cnn/index.xml","videoId":"style/2020/12/03/california-monolith-mystery-pine-mountain-orig-vsop-bdk.cnn","videoImage":"//cdn.cnn.com/cnnnext/dam/assets/201203121509-california-mystery-monolith-1-large-169.jpg","videoUrl":"/videos/style/2020/12/03/california-monolith-mystery-pine-mountain-orig-vsop-bdk.cnn/video/playlists/atv-trending-videos/","description":"Hikers in Atascadero, California, came across u003ca href="http://www.cnn.com/travel/article/california-monolith-found-trnd/index.html" target="_blank">a mysterious metal monolithu003c/a> just a few days after a similar structure was removed from the Utah desert.","descriptionText":"Hikers in Atascadero, California, came across u003ca href="http://www.cnn.com/travel/article/california-monolith-found-trnd/index.html" target="_blank">a mysterious metal monolithu003c/a> just a few days after a similar structure was removed from the Utah desert."},{"title":"Blow off steam by destroying cars at the 'Rage Yard'","duration":"01:00","sourceName":"CNN","sourceLink":"https://www.cnn.com/","videoCMSUrl":"/video/data/3.0/video/world/2020/12/03/rage-yard-cars-newsource-orig-vpx.cnn/index.xml","videoId":"world/2020/12/03/rage-yard-cars-newsource-orig-vpx.cnn","videoImage":"//cdn.cnn.com/cnnnext/dam/assets/201203083524-rage-yard-large-169.jpg","videoUrl":"/videos/world/2020/12/03/rage-yard-cars-newsource-orig-vpx.cnn/video/playlists/atv-trending-videos/","description":"A scrapyard in the UK is offering catharsis by allowing people to take out their frustrations by destroying cars.","descriptionText":"A scrapyard in the UK is offering catharsis by allowing people to take out their frustrations by destroying cars."},{"title":"Rebel Wilson reveals how she hit weight loss goal","duration":"01:33","sourceName":"CNN","sourceLink":"https://www.cnn.com","videoCMSUrl":"/video/data/3.0/video/entertainment/2020/12/02/rebel-wilson-weight-loss-orig-mss-llr.cnn/index.xml","videoId":"entertainment/2020/12/02/rebel-wilson-weight-loss-orig-mss-llr.cnn","videoImage":"//cdn.cnn.com/cnnnext/dam/assets/201202174403-rebel-wilson-large-169.jpg","videoUrl":"/videos/entertainment/2020/12/02/rebel-wilson-weight-loss-orig-mss-llr.cnn/video/playlists/atv-trending-videos/","description":""Pitch Perfect" star Rebel Wilson took to her Instagram account in January to declare that 2020 would be "The Year of Health" for her. Since then, she has been shedding weight and documenting it on social media.","descriptionText":""Pitch Perfect" star Rebel Wilson took to her Instagram account in January to declare that 2020 would be "The Year of Health" for her. 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Another familiar face returns to 'Grey's Anatomy' - CNN

Anatomy

Anatomy of a Bust: How 49ers miscommunication led to an easy Bills touchdown – Touchdown Wire

With 9:50 left in the Bills Monday night game over the 49ers, and Buffalo already up 27-17, quarterback Josh Allen threw a 28-yard touchdown pass to rookie receiver Gabriel Davis in which several San Francisco defensive backs appeared to be very confused. It was a bad play for the 49ers in what turned out to be a 34-24 win for Buffalo.

Pre-snap, you can see cornerback Richard Sherman communicating with safety Dontae Johnson. What might Sherman have been saying? Sherman was probably imploring Johnson to make an alert call to run the coverage to the actions of slot receiver Cole Beasley. Beasley ran a quick five-yard in-cut, while Davis ran up the boundary. In a basic Cover-1 or Cover-3 call, you probably have Sherman on Davis to the boundary, but based on Beasleys actions, that was never the call. Sherman expected to take Beasley inside, while somebody playing safety (perhaps Dontae Johnson) was supposed to cross and take Davis to the outside. Its a coverage called Palms, and it was an unfortunate bust for Robert Salehs defense. Safety Tarvarius Moore was also in the deep third to that side, so yikes.

We were in Palms coverage, Sherman explained after the game. Two into the flat. I adjusted, but we had a few busts on the play. Its unfortunate. The motion put us in a look we hadnt seen before. Its just one of those plays just a miscommunication down the line, and you cant have those plays in games like this.

The look the 49ers hadnt seen before may have been Beasley going in motion from left to right, which could have confused the coverage rules. Shermans alert call should have taken the coverage to that side from zone to Palms.

For those who dont know, Palms coverage can also be called 2-Trap or 2-Read or Soft-2, based on which playbook its in. When I watched tape with Sherman in 2015, he explained how the Seahawks used Palms coverage against Dez Bryant and the Cowboys on this play in which Sherman was playing outside until Bryant took the quick screen behind the line of scrimmage. At that point, Sherman was supposed to crash down on Bryant, which he did, for a three-yard loss. It appeared as if there was a coverage void over Bryant in the slot with Sherman outside, but thats exactly how it was supposed to look.

Its like they call it Soft 2, Sherman told me back then. You have two receivers to your side. If 2 [the slot receiver] goes to the flat five yards or less, the cornerback takes him. If 2 goes vertical past five yards, the corner has man coverage on 1 [the outside receiver]. Since he went bubble [ran a bubble screen], thats five yards or less, and you shoot your gun. Im on 2 until he gets past this point, and then Im on 1. Which sounds easy until I still had to take a gamble on that play, because if I go underneath and I miss, [Bryants] got at least 2030 yards. Then, [safety] Earl [Thomas] will have to chase him downitd be a footrace between him and Dez. If I take that and [Bryant] blocks me, hes up the seam.

So, if Bryant had gone up the seam, the safety would have been responsible for him, and Sherman would have stayed on the outside receiver. The defining point is the slot vertical (if its there) after five yards. Holding the safety back might give a bust disguise look pre-snap. Of course, it helps if your safety is Earl Thomas in his prime.

As this X&O Labs article shows, the responsibility for the alert call into Palms could come from the playside safety in certain instances. We dont know exactly how the miscommunication started in this case, but we sure know how it ended with one of the easiest touchdowns Josh Allen will ever experience.

And if you really want to get into the weeds, heres our friend Cody Alexander on Palms. The 49ers might want to check it out.

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Embryology

Institute of Life-IASO, EuroMediterranean Institute for Quality and Safety in Health Services and Temos Hellas: Certification of clinical results and…

ATHENS, Dec. 9, 2020 /PRNewswire/ --The Institute of Life-IASO, staying committed to its vision for continuous improvement of its procedures and services, has certified its clinical results and success rates.This certification is the first to be issued in Greece.

The certified validation of the Institute's statistical measurements and clinical effectiveness indicators once again establishes Institute of Life- IASOas a point of reference to the international scientific community of Assisted Reproduction Centers.

The certification of results was undertaken by the independent body "EuroMediterranean Institute for Quality and Safety in Health Services" and by Temos Hellas, exclusive agent of Temos International Healthcare Accreditation, after a lengthy procedure to validate statistical indicators and success rates for the Unit. The review was conducted by an age group of women who underwent assisted reproduction and in relation to the method applied to achieve pregnancy.

A special standard was developed for the compliance review procedures in accordance with European Union guidelines on criteria to ensure qualitative and objective statistical reporting, international standards for data verification and the principles of the European Statistics Code of Practice and European Commission Regulation 2017/0048 (COD).

Ms Angeliki Katsapi, Executive Director of the EuroMediterranean Institute for Quality and Safety in Health Services and of Temos Hellas, said: "The verification of the Unit's clinical results focuses on the origin of data and the way they are used in publishing statistical reports and, specifically, to the evaluation of their accuracy, transparency, consistency and comparability. I believe that this innovative certification of clinical results should serve as the beginning of more broadly applied certifications in the sector so that every woman, every couple, are able to obtain full and objective knowledge of the services being offered by health providers."

Mr. Eros Nikitos, Director of the Embryology Lab at the Institute of Life-IASO, noted that: "The certified verification of statistical data of our embryology lab demonstrates in the most reliable manner that we remain true to our vision: To offer the greatest possible chance for a couple to realize its dream. Additionally, the qualitative analysis of data allows us to present to each woman, individually, the realistic possibility of achieving pregnancy based on the specific factors present in each unique case."

The sample reviewed by the Institute's expert scientists, and checked, for its compliance with procedures and data reliability specifications, was drawn from the period November 2018 through November 2019 and verification of data for 2020 is already at its final stages.

bout Institute of Life

Institute of Life, one of the most advanced Assisted Reproduction Centres in Europe, has been created within "Iaso", the largest Obstetrics & Gynecology clinic in Greece and in Southeastern Europe. It was founded by a group of fertility doctors who shared a common dream: to offer patients the best chance of fulfilling their dream of parenthood.

SOURCE Institute of Life-IASO

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Physiology

Five Johns Hopkins faculty named to National Academy of Inventors – The Hub at Johns Hopkins

ByHub staff report

Five Johns Hopkins faculty members have been elected as fellows of the National Academy of Inventors, a prestigious distinction that recognizes and honors the creators or co-developers of outstanding inventions that have made a difference in society. These professors join the more than 4,000 current fellows of the academy, which features members of more than 250 institutions worldwide.

The honorees from Johns Hopkins are:

Ramalingam Chellappa, who joined the Hopkins Department of Biomedical Engineering and the Department of Electrical and Computer Engineering as a Bloomberg Distinguished Professor earlier this year. Chellappa's work has shaped the field of facial recognition technology, and he is known as an expert in machine learning. At Hopkins he contributes to the Mathematical Institute for Data Science and the Center for Imaging Science.

Valina Dawson, a professor of neurology, neuroscience, and physiology in the School of Medicine, and co-director of the Neuroregeneration and Stem Cell Programs in the Institute for Cell Engineering. The lab aims to discover and describe the cell signaling pathways that contribute to neuron survival and death in Parkinson's disease and strokes. In her work, Dawson has discovered new therapies to treat neurological disorders, and established new neurological targets for patients' recovery processes.

Sharon Gerecht, professor of chemical and biomolecular engineering, and director of the Johns Hopkins Institute for NanoBioTechnology. Gerecht is an internationally recognized expert in vascular and stem cell biology and a member of the National Academy of Medicine. Together with her research group, she studies the interactions between stem cells and their microenvironments with the long-term goal of engineering artificial cell microenvironments.

Carol Greider, a professor in the Department of Molecular Biology and Genetics. In 2009, Grieder shared the Nobel Prize in Physiology or Medicine with Elizabeth Blackburn and Jack Szostak for their work on telomeres and telomerase, an enzyme that maintains protective "caps" on the ends of chromosomes. She studies the roles these enzymes play in cancer and age-related degenerative disease.

Nitish Thakor, a professor in the Department of Biomedical Engineering. Thakor conducts research on neurological instrumentation, biomedical signal processing, micro and nanotechnologies, neural prosthesis, and neural and rehabilitation techniques. Director of the Laboratory for Neuroengineering, Thakor also serves as director of the NIH Training Grant on Neuroengineering. Currently, he is developing a next-generation neurally controlled upper limb prosthesis alongside a multi-university consortium funded by DARPA.

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Five Johns Hopkins faculty named to National Academy of Inventors - The Hub at Johns Hopkins

Physiology

Emulate Announces Lung-Chip Technology Used by US Army to Study Effects of COVID-19 – PRNewswire

BOSTON, Dec. 8, 2020 /PRNewswire/ --Emulate, Inc., a leading provider of advanced in vitro models, today announced that its Alveolus Lung-Chip is being used by the U.S. Army to understand how the SARS-CoV-2 virus interacts with lung cells. With funding from the FY20 Coronavirus Aid, Relief, and Economic Security (CARES) Act, researchers at the U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center are using Emulate Lung-Chips to observe intracellular interactions and better understand the role of proteins within lung cells on disease processes.

Emulate Lung-Chip models recreate key aspects of pulmonary physiology by incorporating multiple primary cell types in distinct epithelial and vascular channels in a lung-specific dynamic microenvironment which can mimic tissue-to-tissue interactions, extracellular matrix, immune cell components and mechanical forces. They are ideal for studies looking at viral infection and pathogenesis and efficacy testing.

"In the past, the closest researchers could get to something like this was by introducing a virus into animals and then dissect them. With this, there is no need for animals in performing toxicological research," said Dan Angelini, Ph.D., a Center research biologist, in an Army press release. "For example, we can observe which specific lung cells engaged the virus and allowed it to cross the cell membrane. We can then track the actions of the virus inside the infected cell both recording the virus' mechanisms of pathogenesis and the timing of the damage it causes."

The Alveolus Lung-Chip combines primary human alveolar epithelial cells with primary human microvascular lung endothelial cells. Cells are seeded onto the chips which have been coated with extracellular matrix. A mechanical strain is applied and then air is introduced into the epithelial cell channel. This creates a unique microenvironment which maintains phenotype and functionality of the endothelial and epithelial cells enabling scientists to develop more representative understandings of disease processes and drug responses. These characteristics make it an ideal model for studying the underlying mechanisms of SARS-CoV-2 viral infection.

"Historically technologies for in vitro modelling have been slow to innovate, contributing to a high failure rate in drug development and a limited understanding of human physiological response," said Jim Corbett, CEO of Emulate, Inc. "Advanced in vitro models, such as Organ-Chips from Emulate, are showcasing more predictive outcomes than 2D modeling and animal studies. We are excited the Army is embracing these new technological advances and applying them toward understanding SARS-CoV-2 viral infection and taking critical steps to impact this global health crisis."

The Lung-Chip is part of a complete Human Emulation System from Emulate, which includes chips, instrumentation and hardware. For more information, visit https://www.emulatebio.com/blog/webinar-lung-chip-viral-infection-covid-19

About Emulate, Inc.Emulate Inc.is a privately held company that creates advanced in vitro models for understanding how diseases, medicines, chemicals, and foods affect human health. Our lab-ready Human Emulation System includes three components: Zo Culture Module, Organ-Chips, and analytical software applications. The platform provides a window into the inner workings of human biology and diseaseoffering researchers a new technology designed to predict human response with greater precision and detail than conventional cell culture or animal-based experimental testing. Each of Emulate's proprietary Organ-Chipsincluding the liver, intestine, and kidneycontains tiny hollow channels lined with tens of thousands of living human cells and tissues and is approximately the size of an AA battery. An Organ-Chip is a living, microengineered environment that recreates the natural physiology and mechanical forces that cells experience within the human body. Our founding team pioneered the Organs-on-Chips technology at the Wyss Institute for Biologically Inspired Engineering at Harvard University. Emulate holds the worldwide exclusive license from Harvard University to a robust and broad intellectual property portfolio for the Organs-on-Chips technology and related systems. For more information, please visit emulatebio.com.

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Physiology

Uncovering the Mind-Body Connection of Touch – UANews

By Brittany Uhlorn, BIO5 Institute

Tuesday

Humans are born with the language of touch, and physical connection is essential to our development, growth and survival throughout life.

An infant requires the protective embrace of a parent or caretaker to fully develop, learn trust, and make connections. University of Arizona researcher Dr. Katalin Gothard, born and trained as a medical doctor in Romania, interacted with infants who lacked that physical connection while training at an orphanage during her pediatric clerkship. Due to dictatorial policies in Romania, many orphanages were bursting with unwanted babies while suffering from lack of funds and staff. Because of scarce resources and the goal to keep the children alive, workers prioritized medical needs like preventing malnutrition and infection.

Though she and the staff did their best to keep the children physically healthy, Gothard didn't fully understand the impact that the lack of touch would have on the orphans until she began to study the mind-body connection as a scientist in the United States.

"All those antibiotics and all that nutrition did not make them happier adults," said Gothard, a UArizona professor of physiology and member of the university's BIO5 Institute. "Picking them up, holding them and tickling them would have been much more important."

Though initially educated as a medical doctor, Gothard was also trained as a neuroscientist. Observing the toll of mental and emotional hardships caused in part by the oppressive regime in Romania inspired her to change career paths from medicine to science.

"I strongly believe that there's no human suffering that compares to the suffering that our own mind can inflict on us," she said. "There's no physical disease that compares to the pain and misery and hopelessness of a mental disease."

Gothard now dedicates herself to understanding how physical sensations and experiences affect our emotions. For more than 20 years, the physician-turned-scientist has focused on the amygdala, the almond-shaped mass within the brain, as the critical center of this mind-body dialogue.

In 2019, she and colleagues discovered cells in the amygdala that responded not just to sights and sounds, but also touch something that had never before been shown.

In the moment of the discovery, Gothard felt a strong pull from her earlier days at the orphanage to investigate those touch-responsive brain cells.

"One day we found cells that respond to touch, and it was irresistible. I thought, 'Does that mean that I could work on something that takes me back to those years at the orphanage when I was ignorant, and I didn't know what these babies really needed?'" she said. "It was one of those things in life that you cannot say no to. It walks into your life and you know that from that day on your life will change."

Physical Versus Emotional Responses to Touch

Though we know that a handshake forms a connection, a hug brings comfort and a touch from a stranger feels uncomfortable, scientists and physicians have yet to determine the neural mechanisms behind these mind-body processes. With a $2.1 million grant from National Institutes of Health, a team of trainees led by Gothard and her co-investigator Andrew Fuglevan, a professor of neuroscience and physiology, is seeking to understand how the brain interprets the social, emotional and physical determinants of touch.

Gothard's lab examines the differences in brain activity between gentle grooming on the cheek and a pesky puff of air on the forehead. The researchers observed that the response to the physical aspects of touch when and where occurs much faster than the response to the emotional and social components, like whether the touch was pleasant or from a familiar person.

They also compared the influences of the various touch parameters on emotional state and found that although the objective parameters of touch are processed first, the social aspects were more important in influencing amygdala activity and resulting emotional states.

"If you receive a gentle caress from a person that is not welcome even though the pressure on your skin, the sweep speed, the temperature of the hand might be exactly the same as a welcomed touch your amygdala will say, 'I don't like this,'" Gothard said.

With these findings, Gothard realized the emotional and social consequences of touch, combined with our expectations, outrank the physical.

She and her team found that recipient heart rate at the time of touch correlated with emotional response: When the touch was a positive experience, both the heart rate and amygdala activity slowed, but when the touch was negative, heart rate and amygdala activity both increased. She now aims to find the link between touch and changes to markers in the body, including heart rate, as this causal factor might also be the direct link between touch and changes to amygdala circuitry.

"The more we understand about the brain, the more humble we become about how little insight we have on what's happening inside that dark cranial box," she said.

COVID-19 Causing Touch Deprivation

Gothard hopes her work will one day inform not only the ways humans normally process touch, but also how these circuits can go awry in people with mental illnesses such as social anxiety or schizophrenia, in which the response to touch is more complex. The research may also help to explain how a lack of touch during infancy such as that experienced by orphans leads to attachment disorders later in life.

Implications for Gothard's work further extend to the deprivation of touch during the COVID-19 pandemic. While Gothard stands by the recommendations of social distancing to mitigate the spread of disease, she believes that social isolation during the pandemic will have major, lasting mental health ramifications.

"We are in the middle of uncertainty. What you want in the middle of uncertainty is a hug, but you can't do that right now," she said.

Since physical touch is currently scarce, especially for the elderly and for those who live alone, it's important to find ways to pacify the brain's craving for touch, Gothard said.

She recommends massaging the scalp during hair washing or stimulating the body through physical movement and exercise with the sunshine and breeze. Mind-body scans, such as those often used in yoga and other mindfulness practices, can also help substitute physical touch.

Although these substitutes help to meet the need for physical connection, Gothard said, they cannot fully replace the language of touch we were born to give and receive.

Link:
Uncovering the Mind-Body Connection of Touch - UANews

Physiology

Communication’s Lindsey Aloia Honored with Early Career Award for Prolific Research – University of Arkansas Newswire

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Lindsey Aloia

Lindsey Aloia, associate professor of communication in the Fulbright College of Arts and Sciences, was recently honored with the 2020 Janice Hocker Rushing Early Career Research Award from the Southern States Communication Association.

This award honors untenured, assistant professors with no more than five years in the academy thatare SSCA members who demonstrate exceptional scholarly ability through research and publication.

Aloia's research is prolific. Aloia has published 24 manuscripts, three book chapters, a special journal issue introduction, and has two manuscripts accepted and in production, with seven manuscripts under review.

In addition, she has secured a book contract with Oxford University Press as the lead editor of a handbook on physiology of interpersonal interactions and physiological outcomes of interpersonal communication. Also, Aloia has presented her research findings at 31 regional, national, and international conferences resulting in multiple awards for top papers, articles, and a top dissertation award.

Aloia's work focuses on elucidating the causes and consequences of verbal aggression and in interpersonal communication associations, specifically how qualities of interpersonal interactions, as well as individuals, shape the use of and reactions to verbally aggressive experiences.

In her work, she considers consequential communication to illuminate the emotional well-being, cognitive fitness, physiological health, and behavioral implications of verbal aggression.

In his letter of nomination, Robert Brady, former chair for the Department of Communication, noted "Lindsey joined the communication department at the University of Arkansas in her first assistant professor position in 2015 and immediately impressed me with her exceptional scholarly ability."

He added, "I believe that Lindsey's innovative, theoretically motivated, and rigorous research, combined with her methodological prowess and commitment to the Southern States communication Association make her a strong candidate for the Janice Hocker Rushing Early Career Research Award."

For more information about the Janice Hocker Rushing Early Career Research Award, visit the SSCA online.

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Communication's Lindsey Aloia Honored with Early Career Award for Prolific Research - University of Arkansas Newswire

Physiology

Evaluation of Pulmonary Function Tests Among Pregnant Women of Differe | IJWH – Dove Medical Press

Yosef Eshetie Amare,1 Diresibachew Haile2

1Department of Biomedical Sciences, Institute of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia; 2Department of Physiology, College of Medicine and Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Correspondence: Yosef Eshetie AmareDepartment of Biomedical Sciences, Institute of Medicine and Health Sciences, Debre Berhan University, EthiopiaTel +251910966364Email yophy2006@gmail.com

Introduction: Pregnancy is characterized by a sequence of dynamic physiological changes that impact multiple organ system functions and is associated with various changes in pulmonary anatomy and physiology. Precise knowledge of the pulmonary function test parameters helps to understand and manage the course and outcome of pregnancy leading to safe delivery. It also helps to avoid misdiagnosis and unnecessary interventions. The aim of this study was to evaluate the effect of normal pregnancy on pulmonary function tests among pregnant women in Debre Berhan Referral Hospital, Ethiopia.Methods: A total of 176 study participants (first, second, and third trimester; and control) were involved under a comparative cross-sectional study design and convenience sampling technique. Anthropometric data, oxygen saturation of arterial blood, and pulmonary function tests were measured. Data were tabulated and statistically analyzed using SPSS version 20.0 statistical software. Means of all parameters were compared using one-way ANOVA followed by Tukeys post hoc multiple comparison test. Statistical significance was preset at a p-value of less than 0.05.Results: Mean of FVC for the controls, first, second, and third trimesters was 2.59 0.26, 2.13 0.15, 1.93 0.27, and 1.90 0.11 liters, respectively. Except for FEV1%, the mean values of FVC, FEV1, PEFR, and FEF 25 75% in the pregnant group (all the three trimesters) were significantly decreased from the controls (P< 0.05). Strong negative correlation was seen between SaO2 and RR (r= 0.865; P < 0.01). As the pregnancy progressed from first to the third trimester, dynamic pulmonary function tests (FVC, FEV1, FEF25-75%, and PEFR) were dropped and the respiratory rate increased.Conclusion: The results had shown the tendency of obstructive pattern while pregnancy becoming advanced. We have observed also a remarkable decline of SaO2 in pregnant women that might be counterbalanced by raised respiratory rate.

Keywords: pregnancy, high altitude, FVC, trimester, oxygen saturation

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Evaluation of Pulmonary Function Tests Among Pregnant Women of Differe | IJWH - Dove Medical Press

Physiology

Seymour native, husband prepare to open chiropractic practice – Seymour Tribune

With seven years of college behind her, MacKenzie Ryczek is ready to apply what she learned.

The 25-year-old Seymour native and her husband, Nick Ryczek, graduated from the first and largest college of chiropractic Oct. 23.

That wrapped up MacKenzies postsecondary journey, which started with earning a Bachelor of Arts in science with a major in biology and minor in kinesiology and integrative physiology from Hanover College in 2017 and a Doctorate of Chiropractic from Palmer College of Chiropractic this year.

Now, she and Nick are making an adjustment in opening their own business, New Wave Chiropractic, in Greenwood in the spring of 2021.

Story continues below gallery

I am most looking forward to being able to serve the community, MacKenzie said. Its not a secret that people are getting sicker, yet we are spending the most on health care out of any other country. I want to be a part of the change that is needed to get people back to being healthy. Now more than ever, people are in need of a health change.

MacKenzie said she was in seventh grade when she decided she wanted to attend Palmer.

I have always wanted to be in the health field to help people, but I wanted to do something other than prescribe medications, she said. Chiropractic is about helping people find the root cause of their health concerns and heal them from the inside out.

She graduated from Seymour High School in 2013 before going on to Hanover to earn her undergraduate degree.

I feel that my education from Seymour and Hanover prepared me very well for graduate school, MacKenzie said. Not only the type of classes I took, but the amount of effort the classes required really made me prioritize my education.

The process of applying to chiropractic school included an application with two academic references, an essay and a phone interview.

No specific undergraduate degree is required, but you do have to have a certain amount of science-based classes in order to start the program, MacKenzie said.

Palmer was the only chiropractic school she visited as a prospective student and the only school she wanted to attend. The main campus is in Iowa, and other schools are in San Jose, California, and Port Orange, Florida.

I wanted to go to Palmer in Davenport, Iowa, because it was the first chiropractic college and so much history lives there, she said of the worlds first chiropractic school that was established in 1897.

At Palmer, MacKenzie said she received an excellent education and made many lifelong friends who are now valuable colleagues.

During her first trimester, she joined a club called AMPED, or Advanced Mentorship Program for Entrepreneurial Development.

This group met every week to train on communication, leadership and various business principles to prepare you for opening a practice after graduation, she said. I attended countless conferences and leadership retreats with this organization that has prepared me so much for what I am doing right now.

Making the grade was important to MacKenzie, and that showed by being named to the deans list eight times at Palmer.

I focused on learning and retaining as much information as I could during the classes to prepare for the five parts of chiropractic board exams, she said.

October was a big month because she and Nick were married Oct. 3 and followed that up 20 days later with graduation.

She and Nick met at Palmer.

We were in the same graduating class and had almost every class together for over three years, MacKenzie said. The intensity and demanding nature of going to school at Palmer can put strain on relationships, so it was nice to be able to share that stress and experience with Nick. Being able to graduate together made it easy for us to focus on the same goals right after graduation.

Nick, a Wisconsin native, said it wasnt until his early undergraduate years he realized he wanted to be a chiropractor.

I always knew I wanted to go into health care and help people, but I didnt exactly know where I fit into that until I was introduced to chiropractic, he said. The natural approach of chiropractic really spoke to me, and from that point on, I knew I wanted to go to chiropractic school and practice this amazing form of healing.

Nick said he was lucky to meet MacKenzie at Palmer.

Chiropractic school is pretty tough, so having her to go through everything with me was amazing, Nick said. We were able to keep each other going through the hard times and celebrate the good times together.

The ceremony Oct. 23 was MacKenzies third graduation. Her parents, James Harvey II and Tracy Harvey of Seymour, were in attendance.

It meant so much to be able to walk across the stage and be ceremonially promoted to doctor, she said. I have been in school since 2013 receiving a higher education. This is the first time in my life that I dont have a class to attend or an assignment to do. It feels surreal that I have finally accomplished what I set out to do many years ago.

Getting married and graduating in the same month was almost like running a marathon, she said.

It took a lot of planning and tons of phone calls to be able to graduate with my new last name, she said. It was nice to be able to celebrate the entire month of October with friends and family on our accomplishments.

MacKenzie decided she wanted to open her own practice after she joined AMPED.

This group really gave me the courage and determination to do that, she said. After Nick and I started dating, I brought him into the group and shared my goals and dreams, and I was lucky that he had the same goals, and everything just seemed to work out.

They chose Greenwood for several reasons.

I am very familiar with the area, its really close to Indianapolis but not as busy, its a very family-oriented town and it is going through some major growth, as well, MacKenzie said. We visited Greenwood a few times to just drive around, and it really felt like home.

The Ryczeks will be the only chiropractors and plan to have at least two employees at the start and hire more as they grow.

They are certified in Torque Release Technique, an instrument-based system of analyzing the spine that allows them to make adjustments as gentle and specific as possible. They also are trained to see pregnant women, infants and children of all ages.

Were so excited to start this chapter of our lives and be able make a huge impact on the health of our community, Nick said of opening the practice.

MacKenzie hopes her success story inspires others to pursue their dreams and work toward achieving them.

I hope to serve as an example in that you can do anything you set your mind to, she said. It doesnt matter where you come from, how strange anyone thinks your dream is. You can do whatever you are determined to do. It just takes effort, and it may take a ton of time, but it is so worth it in the end.

Ryczek file

Name: MacKenzie Ryczek

Age: 25

Hometown: Seymour

Residence: Greenwood

Education: Seymour High School (2013); Hanover College (Bachelor of Arts in science with a major in biology and minor in kinesiology and integrative physiology, 2017); Palmer College of Chiropractic (Doctorate of Chiropractic, 2020)

Occupation: Chiropractor

Family: Husband, Nick Ryczek; parents, James Harvey II and Tracy Harvey

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Seymour native, husband prepare to open chiropractic practice - Seymour Tribune

Anatomy

The Anatomy of a Collapse: AKA, How Bears Did the Impossible – Bear Maven

Somehow, Matt Nagy's explanation Monday for what went down on the lakefront Sunday didn't quite suffice.

"It was a higher-scoring game that we weren't able to finish," Nagy said.

And that 1865 scene in Ford's theater was a theatrical production with an interruption.

The complete Bears collapse on Sunday in the final five minutes had numerous intricate pieces involved, and changing any of them might have prevented a catastrophe, even embarrassment.

They could have been tied for the NFC wild-card lead, but their 34-30 loss to the Detroit Lions instead fueled speculation about the firing of Nagy and GM Ryan Pace, if not a restructuring of the entire organization.

Part 1: The Defensive Collapse

Nagy pointed out they've wanted this chance late in games to let their defense tee off without concern over the opponents' running game, so a 30-20 lead with five minutes left was exactly what they wanted.

It would give them a chance for the secondary to make plays on ill-advised, rushed passes. Khalil Mack and Akiem Hicks could rush Matthew Stafford.

"If you asked me in the middle of the season, beginning of the season, where we're at in that situation, I'd tell you 10 out of 10 times we're going to end up with it at the end, we're going to get a big stop, we're going to end the game with the ball in our hands and win," Nagy said.

Instead it was the reverse of the early season when the offense couldn't move and the defense propped up everything.

A 96-yard drive allowed in 2:15 over seven plays and got the Lions a chance at the win.

"I know that our defensive guys in that moment, they get that back, they want another opportunity at that," Nagy said. "We just got to get that one game where all three phases are playing together and I think it will show our guys how sturdy of a team we can be. We just haven't done it."

The defense caved in so poorly that Detroit was able to retain all of its timeouts and also have the two-minute warning left in case they got the ball back, which they did.

"It was obviously well done by them on offense and I think that right there, you know when we look back that's where we want to either be able to make them use more time, at worst make them kick a field goal, but certainly be able to stop them there," Nagy said.

Part 2: The Kickoff Failure

Some teams might try an onside kick with 2:18 remaining. The Lions opted to kick deep. The Bears put their hands team on the field just in case, and had rookie Darnell Mooney back deep instead of Cordarrelle Patterson. He returned it sideways and the Bears were pinned back at their own 11.

Even if Trubisky hadn't fumbled, they'd have been punting from the goal line and giving Stafford plenty of time to manage at least a tying drive.

Nagy said the choice made was intended to make sure they got the ball, more than anything else.

"That's one there where field position-wise, with where that was at and being a three-point game, I think you can certainly go either way," Nagy said. "We decided to go that way with the onside kick, to protect that."

They got the ball, but at their own 11. So the offense was going to need to generate at least one first down and couldn't do it.

Part 3: The Strip-Sack

Mitchell Trubisky tried to pass from inside the pocket. Guard Germain Ifedi, who has been forced to play right tackle due to Bobby Massie's knee injury, didn't stay square in his pass block stance and gave the edge to Romeo Okwara, who came around and knocked it loose as Trubisky got set to throw. Defensive tackle John Penisini recovered at the 7-yard line for Detroit. The throw was meant for Anthony Miller, but Trubisky had an option in safe routes over the middle to Darnell Mooney and David Montgomery, as well. He was going for Mooney.

"Could you go back and could you try to run a screen or do something like that, or throw it behind the sticks and keep the clock running? You could always look at doing that," Nagy said.

The clock wouldn't have run long because the two-minute warning was approaching.

"But we all collectively as a staff, we felt good about that; I think our players did," Nagy said. "It was just something where unfortunately Ifedi, he just kind of opened up his hips a little bit. The kid made a good rush off the edge.

"I think Mitch was just getting ready versus zone when Mooney was getting ready to burst to his last three steps. He was gonna give it to him. And it would have been probably a little short of the sticks and try to fall forward for the first. But timing-wise, we just weren't able to get it out."

Part 4: The Final Drive

The Bears still had a chance at the win and had one timeout left when for some reason Allen Robinson chose to run out of bounds a yard short of the stick when he could have pressed the issue and challenged a tackler who had fallen. If he hadn't gotten out, they had a timeout left but would have had only 11 seconds left to score from the 19 without a timeout. It was a split-second decision.

Robinson twice before this season has shorted a play near the stick and did it again, except this time it was in the closing seconds.

"I have not yet talked to him personally about that yet," Nagy said on Monday. "After a game like that, there are just so many raw emotions that we're all going through. I think that's real. Let it out a little bit from everybody's side, because everybody cares.

"That's one in the heat of the moment when you catch that ball, it is a crucial situation. Allen's a super smart guy. He has a high football IQ. That's one where you think, 'OK, there's not much time on the clock, I need to get out of bounds.' But it's in a position where you can still get the first. And if you get the first, you stay in bounds, then we're going to have to use that timeout, which is what we end up trying to do when we ran the ball on fourth-and-1 and didn't get it.So, I know for sure that Allen was trying to do both; he was trying to get the first and get out of bounds. He did get out of bounds. He didn't get the first."

And Besides All That ...

Two other aspects of the collapse, subplots if you will, went totally unmentioned by Nagy: 1) How the defense went into a fetal position on second-and-goal from the 5 after Trubisky's fumble and 2) the offense's inability to put it away when given the chance.

If they force a field goal after Trubisky's fumble, the last Bears drive only needs to be only for a field goal to win it. They reached the Detroit 20. Cairo Santos has made 16 straight. They should win. Jaylon Johnson and Roquan Smith both had good chances to stop Adrian Peterson on his 5-yard go-ahead TD run but couldn't take him down. And Smith was leading the NFL in solo tackles.

As for the offense, they had just as much responsibility as the defense.

The defense got them the ball back with Bilal Nichols' interception of a Matthew Stafford fourth-quarter screen pass. They had it in Detroit territory on consecutive series after that pick while owning a 30-20 lead. They punted both times.

Change any of these things and Detroit goes home a loser, but instead the Lions made up for their own blown win in the first game of the year by putting the onus of shame back on the Bears.

Twitter: BearDigest@BearsOnMaven

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The Anatomy of a Collapse: AKA, How Bears Did the Impossible - Bear Maven