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Discrimination ups anxiety risk regardless of genetics – The Tribune

New York, January 15

Regardless of genetic risks, exposure to discrimination in life plays a significant role in developing anxiety and related disorders, suggests a new study.

Published in the Proceedings of National Academy of Sciences journal, the study determined that even after controlling genetic risk for anxiety, depression and neuroticism, people reported greater discrimination experiences.

"The results demonstrate that discriminatory experiences can potentially cause stress and mental health problems regardless of the genetic constitution of the individual," said researcher Adolfo G Cuevas, an assistant professor at Tufts University in the US.

To gain insight on the connection, the research team used data from a national probability sample of nearly 1,500 non-institutionalised, all English-speaking adults between 25 to 74 years in age.

Nearly 49 per cent of the sample were women.

Three self-report scales were used to measure discrimination and other forms of social exclusion, including everyday discrimination, major discrimination and chronic job discrimination.

After accounting for increased genetic liability for anxiety, depression, neuroticism, and other potential genetic and socio-demographic factors, the researchers found a high degree of interdependence between discrimination and anxiety.

The team said the findings demonstrate that alleviating the impact of discrimination has the potential to improve mental health within the overall population. IANS

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Discrimination ups anxiety risk regardless of genetics - The Tribune

Scientists discover genetic variations that have a drastic impact on small molecules – News-Medical.Net

The human organism requires a variety of small molecules, such as sugars or fats, in order to function properly. The composition of these so-called metabolites and their interaction - the metabolism - varies from person to person and is dependent not only on external influences, such as nutrition, but also to a significant extent on natural variations in our genetic make-up.

In an international study, scientists from the Berlin Institute of Health (BIH) and Charit - Universittsmedizin Berlin joined forces with colleagues from the United Kingdom, Australia and the United States and discovered hundreds of previously unknown variations in genes that have a sometimes drastic impact on the concentration of these small molecules in the blood. The researchers have now published their findings in the journal Nature Genetics.

The concentration and composition of metabolites - small molecules in the blood or tissue fluid - provide information about biological processes in the human body. They therefore serve as important biomarkers in clinical medicine, for example in the diagnosis of diseases or in checking the effectiveness of a therapy. Interestingly, the composition of metabolites differs from person to person, independent of external influences such as illness or diet.

This is because the blueprints for the proteins that influence metabolite concentration, such as enzymes and transporter proteins, also differ between individuals. Often, the tiniest genetic variants can cause a metabolic enzyme to be more or less active or a transporter protein to be more or less efficient, thus raising or lowering the concentration of metabolites.

The team led by Claudia Langenberg, BIH Professor of Computational Medicine, has now investigated the effect of genetic variants on 174 different metabolites. "We found a surprising number of correlations between certain genetic variants and changes in the concentration of small molecules in the blood," reports the epidemiologist. "In most cases, the genetic variants cause changes in the blueprint of key metabolism regulators, like enzymes or transporters."

To explore these correlations, Langenberg's team needed huge amounts of data.

For our studies, we used large databases that gave us the blood test results and genetic information of a total of around 85,000 people. In doing so, we were able to successfully demonstrate that it is possible to jointly evaluate data from a variety of small individual studies, even across technological boundaries."

Maik Pietzner, Lead Author and Scientist in Langenberg's Laboratory

The scientists' work is highly relevant to medicine, because it can explain how naturally occurring genetic variants that influence the metabolism contribute to the onset of common diseases, such as diabetes mellitus, as well as rare diseases. For example, high levels of the amino acid serine in the blood seem to provide protection against a rare eye disease called macular telangiectasia - knowledge that opens up new therapeutic avenues.

In another study, the authors were also able to show that an individual's genetic risk for altered serine metabolism can aid in the early diagnosis of this serious eye disease. They have also identified a new mechanism that explains how the disrupted transmission of signals via the GLP-2 receptor increases the risk of developing type 2 diabetes.

"What was special about our study were the extreme effects that we observed and their potential relevance for medical research," explains Langenberg. "For example, we were able to detect genetic variants that have an influence on metabolism a good three times as strong as the already known effects of more common genetic variations, for example on body mass index."

To enable scientists around the world to link up their particular fields of expertise with their data, the team has set up an interactive website at http://www.omicscience.org. After all, Langenberg emphasizes, data is only relevant if it can also be used: "We very much hope that these compelling examples will encourage other scientists and doctors to apply our results to their specific research or disease cases."

Source:

Journal reference:

Lotta, L.A., et al. (2021) A cross-platform approach identifies genetic regulators of human metabolism and health. Nature Genetics. doi.org/10.1038/s41588-020-00751-5.

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Scientists discover genetic variations that have a drastic impact on small molecules - News-Medical.Net

Genes and diet can play a role in developing Type 2 diabetes – Norton Healthcare

Type 2 diabetes is genetic in the sense that you may inherit a predisposition to the disease, but not the disease itself. Put another way, a high-fat and high-cholesterol diet and lack of exercise can trigger diabetes in some people, but not others.

Type 2 diabetes runs in families partly because of genetics and partly because children often learn bad habits like poor diet and lack of exercise from their parents. There also is a genetic component to obesity.

Even if you are genetically prone to diabetes, you can delay or prevent it by making healthy food choices, exercising and losing weight.

Heredity and the habits we grew up with help explain why African American adults are 60% more likely than non-Hispanic white adults to be diagnosed with diabetes and twice as likely to die from diabetes, said Steven Patton, D.O., family medicine physician with Norton Community Medical Associates Preston.

Diabetes has its own complications that develop gradually. They include:

Your risk for Type 2 diabetes will determine whether you should have your blood sugar checked as frequently as once per year. If increased blood sugar levels are detected early, losing weight or medication will have a better chance of keeping diabetes at bay.

Checking your blood sugar for signs of diabetes is a simple blood test, and the results are available quickly, especially if youve signed up for a free MyNortonChart account.

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Genes and diet can play a role in developing Type 2 diabetes - Norton Healthcare

Akouos and Blueprint Genetics Announce the Resonate Program to Improve Access to Genetic Testing for Individuals with Auditory Neuropathy -…

BOSTON, Jan. 11, 2021 (GLOBE NEWSWIRE) -- Akouos, Inc. (Akouos) (NASDAQ: AKUS), a precision genetic medicine company dedicated to developing potential gene therapies for individuals living with disabling hearing loss worldwide, and Blueprint Genetics, a Quest Diagnostics company, today announced the Resonate program. The program offers genetic testing to eligible individuals with auditory neuropathy at no cost to participants, their insurance, or their healthcare providers.

Every year, thousands of children are born with disabling hearing loss and the majority of cases of congenital hearing loss are due to an underlying genetic cause. However, few individuals receive a genetic diagnosis and a key barrier is the availability and accessibility of genetic testing. The Resonate program seeks to overcome the barriers to genetic testing for individuals with auditory neuropathy, empower them to make informed choices, and provide potentially valuable insight to inform medical management.

Akouos is committed to deepening the community's understanding of the genetic forms of auditory neuropathy, a type of sensorineural hearing loss. Today, there are no pharmacologic therapies approved for the treatment of hearing loss. The development of new therapeutic options for underserved patient populations has become increasingly reliant on identification of the underlying genetic cause of a genetic disease, disorder, or condition, said Manny Simons, Ph.D., founder, president, and CEO of Akouos. We hope the Resonate program, along with our efforts to better understand the genetic causes and natural history of multiple forms of sensorineural hearing loss, will enable the research and development of novel genetic medicines for individuals with disabling hearing loss.

There are many different genetic changes that cause hearing loss. These changes can be complex and difficult for routine genetic testing to detect. Understanding the genetic cause of hearing loss requires a high-quality genetic testing strategy that includes the mitochondrial genome, difficult-to-sequence genes, and deep intronic variants in addition to copy number variants in order to increase the diagnostic potential for the program participant. We are excited to work with Akouos to offer our comprehensive genetic testing approach to individuals with auditory neuropathy, says Tero-Pekka Alastalo, M.D., Ph.D., executive medical director of Blueprint Genetics.

The Resonate program is available in the United States and plans to expand to additional geographic regions throughout 2021. To be eligible for the program, individuals can be any age, and must have a current or prior clinical diagnosis of auditory neuropathy, or a medical history consistent with auditory neuropathy. Auditory neuropathy is a hearing disorder in which the inner ear successfully detects sound, but has a problem with sending sound from the ear to the brain.In many cases, genetic mutations cause auditory neuropathy. The Resonate program provides access to the Blueprint Genetics Comprehensive Hearing Loss and Deafness Panel that includes more than 230 genes associated with genetic forms of hearing loss. To help understand their results, participants in the United States also have access to genetic counseling provided by the program at no cost to participants, their insurance, or their healthcare providers.

For more information on the Resonate program, individuals and families please visit http://www.akouosresonate.com and healthcare providers please visit http://www.blueprintgenetics.com/resonate-program.

About AkouosAkouos is a precision genetic medicine company dedicated to developing gene therapies with the potential to restore, improve, and preserve high-acuity physiologic hearing for individuals living with disabling hearing loss worldwide. Leveraging its precision genetic medicine platform that incorporates a proprietary adeno-associated viral (AAV) vector library and a novel delivery approach, Akouos is focused on developing precision therapies for forms of sensorineural hearing loss. Headquartered in Boston, Akouos was founded in 2016 by leaders in the fields of neurotology, genetics, inner ear drug delivery, and AAV gene therapy. http://www.akouos.com

About Blueprint GeneticsBlueprint Genetics, a Quest Diagnostics company, is a leading specialty genetics and bioinformatics company focused on providing genetic testing for inherited diseases. The company is based in Helsinki and Seattle, with a customer base spanning over 70 countries.www.blueprintgenetics.com

Cautionary Note Regarding Akouos Forward-Looking StatementsStatements in this press release about Akouoss future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements relating to the expectations for the Resonate program and the roll-out of the Resonate program. The words anticipate, believe, continue, could, estimate, expect, intend, may, plan, potential, predict, project, should, target, will, would and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: Akouoss plans to develop and, if approved, subsequently commercialize Akouoss product candidates; the timing of and Akouoss ability to submit applications for, and obtain and maintain regulatory approvals for, Akouoss product candidates; Akouoss expectations regarding Akouoss regulatory strategy; Akouoss expectations regarding Akouoss ability to fund Akouoss operating expenses and capital expenditure requirements with Akouoss cash, cash equivalents and marketable securities; the potential advantages of Akouoss product candidates; the rate and degree of market acceptance and clinical utility of Akouoss product candidates; Akouoss estimates regarding the potential addressable patient population for Akouoss product candidates; Akouoss commercialization, marketing and manufacturing capabilities and strategy; Akouoss expectations regarding Akouoss ability to obtain and maintain intellectual property protection for Akouoss product candidates; Akouoss intellectual property position; Akouoss ability to identify additional products, product candidates, or technologies with significant commercial potential that are consistent with Akouoss commercial objectives; the impact of government laws and regulations; Akouoss competitive position and expectations regarding developments and projections relating to Akouoss competitors and any competing therapies that are or become available; developments and expectations regarding developments and projections relating to Akouoss competitors and Akouoss industry; the impact of the COVID-19 pandemic on Akouoss business, results of operations, and financial condition; Akouoss ability to maintain and establish collaborations or obtain additional funding; and other factors discussed in the Risk Factors included in Akouoss Quarterly Report on Form 10-Q for the three months ended September 30, 2020 filed with the Securities and Exchange Commission, and in other filings that Akouos makes with the Securities and Exchange Commission in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and Akouos expressly disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

Akouos

Media:Katie Engleman, 1ABkatie@1abmedia.com

Investors:Courtney Turiano, Stern Investor RelationsCourtney.Turiano@sternir.com

Blueprint Genetics

Tero-Pekka Alastalo, executive medical directortpa@blueprintgenetics.com

Saara Salonoja, communication specialistsaara.salonoja@blueprintgenetics.com

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Akouos and Blueprint Genetics Announce the Resonate Program to Improve Access to Genetic Testing for Individuals with Auditory Neuropathy -...

Medscape study in collaboration with 23andMe finds Primary Care Physicians are increasingly more comfortable with direct-to-consumer genetic health…

"This study highlights a significant shift in how primary care physicians view DTC genetic health testing."

The report also found 80 percent of PCPs are open or likely to recommend DTC genetic testing for health if asked about it by their patients, and for 61 percent of PCPs, FDA oversight of health reports was a necessary element of any DTC genetic test they might recommend.

"This study highlights a significant shift in how primary care physicians view DTC genetic health testing," said L. Okey Onyejekwe Jr., MD, JD, Vice President of Healthcare Operations and Medical Affairs at 23andMe. "In just two year's time, the data show PCPs are much more accepting, and in some cases wholeheartedly embracing this type of testing, especially tests that include health reports with FDA oversight. As more consumers turn to DTC genetic testing for health insights into their genome, it's encouraging to see that PCPs are much more open to patients bringing their test results into the clinic for further discussion and potential follow up testing when warranted."

When it comes to all genetic testing, not just DTC genetic testing, 71 percent of PCPs are comfortable making appropriate referrals to specialists based on genetic information, compared to 44 percent in 2018. Further, 46 percent of PCPs are comfortable ordering genetic testing, a four-fold increase from 2018, and 41 percent are comfortable using genetic information to make treatment decisions, a two-fold increase over 2018.

"The shift in the primary care community's point of view on genetic testing over a relatively short period of time is striking, and points to the tests results having greater utility and impact in patient care," said Hansa Bhargava, M.D., Medscape Senior Medical Director. "We are pleased that we could contribute to increasing awareness of the role of genetic testing in the primary care environment."

Methodology

This report was completed by 1,000 U.S. primary care physicians on the Medscape platform between August 26, 2020 and September 14, 2020. Ninety percent of respondents practice Family or Internal medicine and respondents have practiced an average of 19 years. Respondents were invited to respond to the online survey. The margin of error at a 95% confidence level is +/- 3.0%. The report is a follow-up to a 2018 report on the same topic, which was completed by 1,000 U.S. primary care physicians on the Medscape platform between October 25, 2018 and November 22, 2018.

About Medscape

Medscape is the leading source of clinical news, health information, and point-of-care tools for health care professionals. Medscape offers specialists, primary care physicians, and other health professionals the most robust and integrated medical information and educational tools. Medscape Education (medscape.org) is the leading destination for continuous professional development, consisting of more than 30 specialty-focused destinations offering thousands of free C.M.E. and C.E. courses and other educational programs for physicians, nurses, and other health care professionals. Medscape is a subsidiary of WebMD Health Corp.

About WebMD Health Corp.

WebMD Health Corp., an Internet Brands Company, is the leading provider of health information services, serving patients, physicians, health care professionals, employers, and health plans through public and private online portals, mobile platforms, and health-focused publications. The WebMD Health Network includes WebMD Health, Medscape, Jobson Healthcare Information, prIME Oncology, MediQuality, Frontline, Vitals Consumer Services, Aptus Health, MedicineNet, eMedicineHealth, RxList, OnHealth, Medscape Education, and other owned WebMD sites. WebMD, Medscape, CME Circle, Medpulse, eMedicine, MedicineNet, theheart.org, and RxList are among the trademarks of WebMD Health Corp. or its subsidiaries.

About 23andMe

23andMe, Inc. is the leading consumer genetics and research company. Founded in 2006, the mission of the company is to help people access, understand, and benefit from the human genome. 23andMe is the first direct-to-consumer company to receive FDA authorization for genetic health reports, and has millions of customers worldwide, with more than 80 percent of customers consented to participate in research. 23andMe, Inc. is located in Sunnyvale, CA. More information is available at http://www.23andMe.com.

SOURCE 23andMe

https://www.23andme.com/en-ca/

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Medscape study in collaboration with 23andMe finds Primary Care Physicians are increasingly more comfortable with direct-to-consumer genetic health...

Misrepresentation of self-reported drinking and genetic studies – RACGP

News

New research investigates whether misreporting and changes in behaviour can prejudice the results of genetic studies on alcohol consumption.

It is well known that modifying behaviours and lifestyle can serve as risk or protective factors for common diseases.Alcohol consumption presents one of the most common harms, particularly for increased risk of cardiovascular and metabolic diseases and mental health. A number of large-scale epidemiological studieson alcohol consumption conclude that no level of alcohol consumption improves health.But according to new research, this conclusion may contradict negative estimates of the genetic link between alcohol consumption and some diseases including obesity, major depressive disorder, Parkinsons disease, and type 2 diabetes as reported in recent genome-wide association studies identifying numerous genetic variants associated with human behavioural traits.It is also contradictory to the protective effects of moderate drinking reported in observational studies.The recently published observational study found genetic studies that rely on self-reported drinking may be biased by misreporting and changes in behaviour. The study found conflicting results from some genetic studies in that people with genetic-based tendencies towards drinking alsohave lower rates of somediseases, suggesting a possibleprotective effect of alcohol against disease.One possible explanation the authors found was that patients with a disease may change their alcohol consumption upon diagnosis, or misreport their alcohol consumption in a survey.According to the authors, behavioural traits are subject to misreports and longitudinal changes, and misreports are common in self-reported data setsbut often overlooked in genetic analyses. This can cause biases in genome-wide association studies and follow-up analyses.These misreports are mainly attributed tosocial desirability, when the tendency for participants to answer questions is in ways that make them viewed favourably by others, and recall bias, when the accuracy and completeness of past events recalled by participants are influenced by subsequent events that they experienced.It is hoped the study findings will help explain conflicting reports about the link between alcohol consumption and certain diseases.Using data from 455,607 individuals in the UK Biobank, the researchers investigated biases due to misreports and longitudinal changes in genetic analyses of self-reported behavioural traits, including alcohol consumption, tobacco smoking, and physical activities, without correcting for misreporting or changes in behaviour.Their findings were negative genetic correlations between alcohol consumption and type 2 diabetes, hypertensive disease and iron deficient anaemias. After correcting for misreporting and behavioural changes, the negative correlations disappeared and they found positive correlations with eight different conditions, including cardiovascular disease and total disease count.Our studies demonstrate that individuals with higher disease burden in the UK Biobank are more likely to misreport or reduce their alcohol consumption levels, and propose a correction procedure to mitigate the misreports and longitudinal changes-induced biases, the authors wrote.The alcohol consumption genome-wide association studies signals removed by the misreports and longitudinal changes corrections are enriched in metabolic/cardiovascular traits. Almost all the previously reported negative estimates of genetic correlations between alcohol consumption and common diseases become positive/non-significant after the misreports and longitudinal changes corrections.Another important source of bias noted by the authors is the change in amount of alcohol consumption during the life course, for reasons such as changes in health status. For example, if people change their level of alcohol consumption because they are affected by a disease, the diagnosis will give rise to a bias in observed or genetic relationship between alcohol consumption and the disease.The authors anticipate the results of this study will demonstrate the significance of potential biases in genetic studies of behavioural traits, and provide a method to correct them for future research. They do note, however, that this bias does not necessarily apply to all populations or behavioural traits.Our findings provide a plausible explanation of the controversy about the effects of alcohol consumption on health outcomes and a caution for future analyses of self-reported behavioural traits in biobank data, the authors wrote.Log in below to join the conversation.

alcohol consumption genetics preventive health

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Misrepresentation of self-reported drinking and genetic studies - RACGP

Here’s why spite spreads in peopleand thrives in politics – News@Northeastern

Last week, a violent mob of Trump supporters stormed the United States Capitol, seeking to delay certification of the 2020 presidential election results. The riot failed to achieve its goal, and dozens have been arrested and charged. Why did so many people risk their safety, their employment, and tarnish their criminal record for the purpose of harming others? One potential factor at play may be the infectious nature of spite.

Spite is a puzzling human behavior. Its the act of causing harm to another while gaining no benefit for ones self. And although it is costly to all involved, a new study finds that it is also highly contagious.

Left, Christoph Riedl, associate professor of information systems in the DAmore-McKim School of Business and Khoury College of Computer Sciences. Photo by Adam Glanzman/Northeastern University. Right, Rory Smead, associate professor of philosophy and the Ronald L. and Linda A. Rossetti Professor for the Humanities in Northeasterns College of Social Sciences & Humanities. Northeastern University file photo.

In a paper published yesterday in Nature Communications, Northeastern researchers provide a novel explanation for how spiteful behavior originates and spreads. Using a computational model that simulates human interactions, researchers observed spite spread throughout a dynamic network until every agent became spiteful, and cooperation ceased entirely.

Traditionally, mathematical models of human behavior have lacked an important component: they arent dynamic, meaning the simulated actors dont behave like real people do within real social circles. Old models were built on a uniform population that interacted randomly. This kept the math simple but made the network interactions unrealistic. The new dynamic model used in the study allows agents to choose whom they mingle with, like people do in real life.

The network structures we find in the simulation are similar to what we know human social networks look like, says Christoph Riedl, associate professor of information systems in the DAmore-McKim School of Business and Khoury College of Computer Sciences and co-author of the paper. The dynamic model is not random, its meaningful and realistic. It seems to pick up on how humans actually behave.

The model showed that spiteful agents targeted non-spiteful players, draining their resources so the spiteful agents looked better in comparison. This resulted in the initially non-spiteful agents realizing they were worse off and perpetuating the spite to get ahead. Researchers found that it continued to spread until there were no cooperative players left.

Spite is a net loss for everybody, but it changes the relative standings of individuals, says Rory Smead, associate professor of philosophy and the Ronald L. and Linda A. Rossetti Professor for the Humanities in Northeasterns College of Social Sciences & Humanities and co-author of the paper. Zachary Fulker, a PhD student in Northeasterns Network Science Institute, was the papers lead author.

That perceived relative advantage is what makes spite so infectious in human networks. Its also the reason spite thrives in politics.

Politics is often a zero-sum game. In order for you to win, the other guy has to lose, Smead says. Certain politicians may view these political interactions as situations in which cooperation is not possiblesituations in which they might be willing to pay costs in order to make sure the other side suffers even more. Its those relative tradeoffs where spite finds a home.

In political elections, it doesnt matter how many total votes are cast, only that one side gets more votes than the other. This is an environment ripe for spite.

If there is voter suppression and everyone gets fewer votes, thats not necessarily bad for me as long as I get more than you, Riedl says.

The outcome for a society infected by spite may look bleak, given how contagious this behavior can be. But understanding the obstacles that undermine cooperation can help get us closer to achieving it.

Its an important piece to the broader puzzle of how we can all get along better, says Smead.

For media inquiries, please contact media@northeastern.edu.

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Here's why spite spreads in peopleand thrives in politics - News@Northeastern

We must understand the threat from within – The CT Mirror

I am a student of history and human behavior. I am the sole college educated member of my working class family who consider me a radical liberal and elitist. Clearly, they have aligned with right wing media who have branded those who share my political and social leanings.

Like many Americans, I am outraged by the violent attack on our Capitol, in the name of patriotism, but recognize it for what it is. While it was fomented by conspiratorial elements in our government, social media, and dangerous fringe groups, there is no conspiracy in believing that it was a heinous assault on our democratic process and the rule of law. We must see it for what it is.

There are those among us who threaten to destroy the fabric of this nation. Truth be told, these events are evidence that we are a nation, deeply divided, and that our republic, if we can keep it, remains vulnerable from within. It seems that the countermeasure to this threat is to assess how we got here, address the etiological factors, and commit to every possible measure to strengthen our democracy. This includes a better understanding of our nations ills.

While it is easy to dismiss the insurrectionists as thugs and misfits, let us consider that they may be a consequence of a society that has left them behind; sons and daughters of poverty, a failed education or mental health system, joblessness, technology, or social change, who perceive themselves as victims with few options. Clearly, Trump has played them, and seduced them into aligning with his own pathological view of victimization, manipulated them for his own political gain. That said, the villains of the recent insurrection are a threat to our democratic way of life, and must be accountable for their actions. We cannot allow laws to be violated, elections to be overturned by mobs, and the tenets of our Constitution to be defiled.

As a people, we must recognize the inequities in our society, and the deleterious impact on our citizens. If democracy is to survive into the next century, we must begin to address the consequences of economic disparity, racism, social injustice, hopelessness, and diminished opportunity, and mitigate these pernicious forces. Despite the historic roots of these problems, and contemporary factors that reinforce them, we must face the challenges of the future with new hope and commitment.

We need to work together to protect our democracy, and human rights, and to condemn the voices of division. We must also demand that our elected officials return civility to government and maintain their oath of office to protect our Constitution. Anything less is a betrayal of their country, voter rights, and the bedrock of a democratic nation.

Claire Walsh, a social worker, lives in Deep River.

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We must understand the threat from within - The CT Mirror

What happened to flu season? Experts talk COVID-19, vaccines and more – KEZI TV

LANE COUNTY, Ore. -- As the talk of coronavirus dominates our daily conversation, some people are asking: what happened to the flu?

Dr. Brenda Ormesher is an Infectious Disease Physician with PeaceHealth Medical Group. She along with several other doctors KEZI 9 News spoke to said they have seen very low flu activity within the community.

The measures that we've put in place for COVID prevention have done a lot to help prevent the flu in Lane County, Ormesher said.

But thats not all.

We did have higher rates of vaccination this year compared to prior years, so that's excellent because more people have become engaged, Ormesher said. They've taken measures to help prevent the spread of influenza, and that community engagement has made such a big difference.

Dr. Patrick Luedtke with Lane County Public Health agrees.

We are of course attributing that really to human behavior, Luedtke said. People are wearing masks -- not 100% but they can still do better. Many of them are wearing masks. Secondly, people are avoiding these congregate settings where we typically pass it.

He said labs have shown a nearly 75% reduction in flu cases so far this year, but he said anything could happen.

We could still very well see a big peak in influenza in February, March or April, Luedtke said. "So people still have time to get protected, and we really want them to.

Luedtke said that in a typical year there is so much influenza that it is not a reportable disease. That would only change if officials noticed a novel strain.

In the 2019-2020 season, the CDC estimated 22,000 deaths from the flu. Across the country, many states have reported none so far.

Health officials have warned about the dangerous reality of coinfection -- thats an individual becoming infected with both COVID-19 and the flu. Ormesher said theyve only seen one case of that in a nursing home.

The flu shot is definitely important, even with low cases, Ormesher said. If we start seeing that spread in our community, in addition with COVID, that would be detrimental to the health care facility and it would be detrimental to the patients.

In Oregon, between Dec. 27 and Jan. 2 this season, there were 0.1% of positive flu tests.Last season, that number was at 26.6% in the same time span.

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What happened to flu season? Experts talk COVID-19, vaccines and more - KEZI TV

What The CES All Digital Show Says About the Future – Nextgov

Last year I was unable to attend the Consumer Electronics Show (CES) in person, but was fortunate enough to have a few colleagues covering the event. They sent back reports about the newest technology that would soon be populating inside our homes and offices. This year, however, nobody can get to the show because of the ongoing pandemic. Its gone completely virtual. On the bright side, that means that all of the keynotes are open to everyone who wants to stream them. A few companies have even set up virtual booths that you can visit without leaving your home.

The bad news is that the number of exhibitors is way down this year, with fewer than half as many as attended the last physical show in 2020. That makes my job for Nextgov a little bit more difficult. Its not always easy to pick out potential government technology at CES because its hyper-focused on consumer products like televisions. In the past, however, the sheer number of exhibitors, which could sometimes soar into the thousands, meant that spotting government trends or tech that government might be interested in was at least possible by wearing down the soles of your shoes wandering around the multi-level, maze-like complexes that hosted the show.

I didnt have to do any wandering this year, but there was also less to find. Even so, CES offered quite a few interesting nuggets that might hint at future government technology.

5G Will Finally Be Everywhere

In 2019, the concept of 5G was just starting to roll out, and companies were beginning to imagine what customers could do with bandwidth that was up to 25 times faster than was available at the time. Verizon CEO Hans Vestberg keynoted CES that yearand talked about the pending new technology almost as if it were magic. He was back this year to kick off the 2021 virtual show, but with many more real-world examples. According to Verizon, their 5G service is now available in 2,700 cities serving 230 million people.

At the show, images of blockbuster movies being downloaded over lightning-fast connections in seconds were highlighted, but government is already investing in more practical 5G projects, a trend that will continue as the technology proliferates. For example, much of the Department of Defenses digital modernization strategy will depend on 5G communications.

Its not just the speed that makes 5G useful in government and the DOD. The core of the 5G transport layer is almost fully comprised of software-defined networking technology. That gives the DOD a lot more control over its data and bandwidth. For example, by using network slicing, they can allocate bandwidth based on mission priorities going all the way out to the edge. That way something like a critical video feed coming in from a drone in a forward area can have more than enough bandwidth dedicated to it so that it can stream its feed in real-time without getting disrupted by other applications on the same network.

The intelligence community is also interested in similar projects relating to 5G. In September, the Defense Information Systems Agency released a request for information about how it could deploy dynamic spectrum sharing across a broad range of capabilities. Specifically, it wants to improve bandwidth allocation in the areas of training, readiness and lethality. The backbone of 5G is almost tailor-made to drive specific projects, giving greater control for both public networks and the more highly classified, closed environments used by the IC.

IoT Getting Back to Its Roots

Although 5G is driving many of the innovations on display at CES this year, the really interesting stuff stems from the innovative applications that use it. I wrote a lot about smart cities over the past few years, including some truly innovative towns that are really pushing the envelope on what is possible. One of the most advanced places was Peachtree Corners, Georgia, where much of the infrastructure is computer-controlled using internet of things sensors and artificial intelligence.

One of the main partners working in Peachtree Corners is Bosch, which installed many of the IoT sensors around town as well as the artificial intelligence that drives them. At CES this year, Bosch described their work in this area.

Bosch CTO Michael Bolle explained that while most companies in 2020 focused on building AI to predict or model human behavior, they instead built what they are calling industrial AI and merged it with IoT. In Boschs AIoT program, they concentrate on explaining the world to objects and machines, and teaching them how to interact with it.

By explaining the physical world to machines instead of trying to make them think like humans, it makes for a much more functional AI that can be employed in a variety of situations that might really drive smart cities and other practical applications into overdrive in 2021 and beyond.

Self-Driving Cars Pulling into Your Neighborhood

Another huge technology that will benefit from 5G is self-driving vehicles. We saw a few pilot programs in different states over the past few years, as well as some Congressional approval to explore this new technology. And at CES last year, you almost couldnt wander the show floor without bumping into a self-driving car or even a self-flying airplane.

Without a physical presence, there was much less emphasis on cars this year. However, one company was taking pilot programs and moving them into the real world, with big plans for major rollouts by 2025.

That company is called Mobileye, and is a subsidiary of Intel. They took a unique approach to developing their self-driving vehicles, namely doing a lot of the most difficult tasks, like mapping hundreds of miles of potential streets, roads and routes before trying to then interface that data with their vehicles. At CES, they announced that they had mapped almost a billion kilometers of roads for their vehicles, and add about eight million more every day. When the mapping is combined with its safe-driving AI, it makes for a safe and efficient ride for passengers.

Last year the company tested its cars in Germany and logged thousands of driverless trips with passengers. It plans to quickly scale to other countries and cities, so you might see a Mobileye vehicle in your neck of the woods very soon. Beyond just that success, their method of getting self-driving cars deployed quickly and safely could become a roadmap for other private or government projects in this area.

From the beginning, every part of our plan aims for rapid geographic and economic scalability and todays news shows how our innovations are enabling us to execute on that strategy, said Mobileye CEO Amnon Shashua.

Virtual CES runs through January 14th this year, so there is lots more to see. The good news about a virtual show is that even if you miss a keynote or a presentation, its still going to be available online anytime. So sit back and enjoy seeing what technology the future may hold.

John Breeden II is an award-winning journalist and reviewer with over 20 years of experience covering technology. He is the CEO of the Tech Writers Bureau, a group that creates technological thought leadership content for organizations of all sizes. Twitter: @LabGuys

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