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Genetic Liability to Smoking Linked to Atherosclerotic Cardiovascular Disease – MD Magazine

January 22, 2021 medical

While smoking is linked to atherosclerotic cardiovascular disease (ASCVD), the relative contribution to each subtype is not entirely understood.

A team, led by Michael G. Levin, MD, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine, determined the link between genetic liability to smoking and the risk of coronary artery disease (CAD), peripheral artery disease (PAD), and large-artery stroke.

In the mendelian randomization study, the investigators used summary statistics from genome-wide associations of smoking from the UK Biobank (n = 462,690), Coronary Artery Disease Genome Wide Replication and Meta-analysis plus the Coronary Artery Disease Genetics Consortium (n = 60,801 cases, n = 123,504 controls), VA Million Veteran Program (n = 24,009 cases, n = 150,983 controls), and MEGASTROKE (n = 4373 cases, n = 406,111 controls).

The investigators sought main outcomes of risk, defined as odds ratios (OR) of CAD, PAD, and large-artery stroke.

The researchers used 2 measures for smoking throughout the studylifetime smoking index and smoking initiation. The primary measure of smoking was lifetime smoking index, which was previously validated continuous measure that accounts for self-reported smoking status, age at initiation, age at cessation, number of cigarettes smoked per day, and a simulated half-life constant that captures the decreasing effect of smoking on health outcomes following a given exposure.

Link Between ASCV and Smoking

The investigators found genetic liability to smoking was linked to an increased risk of PAD (OR, 2.13; 95% CI, 1.78-2.56;P= 3.61016), CAD (OR, 1.48; 95% CI, 1.25-1.75;P= 4.4106), and stroke (OR, 1.40; 95% CI, 1.02-1.92;P= 0.04).

The team also found the genetic liability to smoking was associated with a greater risk of PAD than risk of large-artery stroke (ratio of OR, 1.52; 95% CI, 1.05-2.19;P= 0.02) or CAD (ratio of OR, 1.44; 95% CI, 1.12-1.84;P= 0.004).

The link between genetic liability to smoking and atherosclerotic cardiovascular diseases was independent from the effects of smoking on traditional cardiovascular risk factors.

In this mendelian randomization analysis of data from large studies of atherosclerotic cardiovascular diseases, genetic liability to smoking was a strong risk factor for CAD, PAD, and stroke, although the estimated association was strongest between smoking and PAD, the authors wrote. The association between smoking and atherosclerotic cardiovascular disease was independent of traditional cardiovascular risk factors.

The Dangers of Smoking

Atherosclerotic cardiovascular disease impacts a number of vascular beds throughout the body, with clinical manifestations. Smoking tobacco is consistently among the leading risk factors for atherosclerotic cardiovascular disease.

Smoking also had independent effects on inflammation, endothelial function, and platelet aggregation, but it is unknown whether the effect of smoking on atherosclerotic cardiovascular disease is primarily mediated through correlated alterations of traditional cardiovascular risk factors or operates through independent mechanisms.

While the detrimental effects of smoking could persist for decades, clarifying the basis of the smoking-atherosclerosis relationship might enable more targeted risk-reduction strategies among both current and former smokers.

The study, Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases, was published online in JAMA Network Open.

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Genetic Liability to Smoking Linked to Atherosclerotic Cardiovascular Disease - MD Magazine

Genetics

For COVID Peace of Mind – and No Swab Up Your Nose – Huntsville Hospital and Kailos Genetics Roll Out Assure Sentinel – Huntsville Business Journal

January 22, 2021 medical

Two issues negatively impacting COVID testing are false readings and the turnaround time it takes for results. False positive results can cause undue concern, whereas false negative readings have the potential to unwittingly add to the continued spread of COVID.

The waiting game is especially difficult; its the kind of time that most people dont really have to spare. They must then play the quarantine game which, in addition to the restrictions, often means a loss of income as they wait for their results.

To overcome these hurdles, Huntsville Hospital and Kailos Genetics have teamed up to offer a COVID-19 test option through its Assure Sentinel and Peace of Mind programs. The programs are designed for non-symptomatic individuals who want to know if they are carrying the COVID-19 virus.

Its the second program weve put into place with Huntsville Hospital, said Troy Moore, chief science officer at Kailos, which is headquartered at the HudsonAlpha Institute for Biotechnology. The first program was focused on a return to work or return to school testing, on a routine basis. Then, we learned there were quite a few people that had a son or daughter going back to school or to college, or theyve been around family members during the holidays, or they have a parent they are taking care of.

This is a place where they could go if they have concerns, but not necessarily a known exposure event.

In this partnership, the hospital staff will administer the test, collect samples, and deliver the results. Kailos will process the tests utilizing its Assure Sentinel program which can detect SARS-CoV-2, the virus that causes COVID-19.

Assure Sentinel testing is painless and affordable and can detect viral infections in individuals before they become symptomatic. By reducing the potential for exposure, Sentinel testing helps to minimize the impact in the workplace, as well as in the community.

The best news is the process is a saline swish and gargle the companys ViraWash to provide a viable sample. No long swab going up your nose and it can be easily done in the workplace.

For more information, contact the Huntsville Hospital Clinical Lab at: 256-265-2LAB (2522).

Original post:
For COVID Peace of Mind - and No Swab Up Your Nose - Huntsville Hospital and Kailos Genetics Roll Out Assure Sentinel - Huntsville Business Journal

Biochemistry

EXPRESS: SARS-CoV-2 (covid-19): a short update on molecular biochemistry, pathology, diagnosis and therapeutic strategies – DocWire News

January 22, 2021 medical

This article was originally published here

Ann Clin Biochem. 2021 Jan 21:4563221992390. doi: 10.1177/0004563221992390. Online ahead of print.

ABSTRACT

The ongoing coronavirus (covid-19) pandemic highlights the need for global scientific cooperation to advance our understanding of the immunological, molecular and biochemical mechanisms causing infection by this virus. Better understanding of key processes has allowed development of vaccines in record time, and of agents with the potential to treat and neutralise current and future coronavirus outbreaks. To date, clinically effective agents for prevention and treatment of covid-19 infections are limited. This review provides a brief synopsis regarding the molecular biology, pathology and laboratory tests commonly used in the diagnosis and prognosis of covid-19, as well as the development of vaccines and therapeutic strategies to manage its current and future mutations.

PMID:33478237 | DOI:10.1177/0004563221992390

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EXPRESS: SARS-CoV-2 (covid-19): a short update on molecular biochemistry, pathology, diagnosis and therapeutic strategies - DocWire News

Biochemistry

School of Molecular Sciences students reflect on their first semester in the middle of the pandemic – ASU Now

January 22, 2021 medical

January 19, 2021

The 2020 pandemic changed many things including the college experience for first-year students.

The excitement to attend the first football game as a new addition to the Sun Devil family and step foot into their first-ever college lecture, for the most part, did not happen traditionally. Though it was challenging and uncertain how the future would look, many of the freshmen from Arizona State University's School of Molecular Sciences did not let the pandemic get in the way of achieving their academic goals. School of Molecular sciences freshmen (from left): Sydney Pickett, Eric Do, Jessica Wang and Gabriella Cerna Download Full Image

Here, several first-year students from the school talk about their first semester at ASU in the middle of the pandemic.

Sydney Pickett is in the BS biochemistry program; she is one of the many students who excelled in her first semester at the School of Molecular Sciences. Her drive to attain her goals comes from her dream of attending medical school.

Overwhelming was the word she used to describe her first semester of college. Her biggest challenge was being an out-of-state student: Not knowing anyone from Arizona and also trying to adjust to a new city and a completely new environment made her nervous.

She felt homesick often but was able to overcome it with the help of her support system back at home. With her family and friends' encouragement she achieved her goals of meeting new people by stepping outside of her comfort zone, on top of attaining straight As for the semester.

Her new goals for the year are to get a shadowing position and maintain her 4.0 GPA.

One thing I learned is that it is OK to make mistakes and to mess up sometimes. Just be resilient and do not give up, she said.

Eric Do, a BS medicinal biochemistry major, on the other hand, was frustrated when he realized that his first semester of college would be during the pandemic. He didnt get to meet new people or explore the ASU campus as much as he wanted to.

For him the online learning environment was challenging due to it being difficult to focus in a setting outside of a physical classroom. One of his most difficult courses of the semester was CHM 117: General Chemistry for Majors I. Though it was challenging, a perk he received was attending the in-person lab with fewer students, which allowed him to ask the lab instructor more questions if he had any.

His motivation to succeed this semester came from his goals, friends who were in the same situation and his aspirations to become a future pharmacist, which helped him attain straight As. His goals for the upcoming semester are to improve his work-life balance.

I would like to thank my instructor Tim Lamb for being my guide through my first semester, he said.

Jessica Wang is a medicinal biochemistry BS major who has looked forward to her first year in college since she was a child. She wanted to explore her independence, and she knew traveling across the country was the best way to achieve it.

But due to the pandemic, she was initially disappointed with the way her experience turned out.

I felt as though I was taking a step backwards towards my self growth rather than it being an opportunity for new experiences, she said.

What kept her motivated through the semester was her goal of self growth and sense of independence. She found herself doing something different every week, and while it felt overwhelming at times, she never wanted it to stop.She has made the most of her time at ASU by taking advantage of great opportunities that came her way.

She also made good friends during the first semester.

I got very lucky this semester. Having made such a strong friendship with my roommate, we spend most of our time together, she said.

Although it was not ideal, Gabriella Cerna, who is majoring in biochemistry and microbiology, was very grateful that she had the opportunity to attend college in a safe environment.

Transformative is the word she used to describe her semester, because she was able to discover herself and her beliefs through being exposed to many different ideas and viewpoints. Her biggest motivation was her drive to continue learning.

Instead of focusing on external factors like grades, I concerned myself with truly enjoying and understanding the content in my classes, she said.

During her first year she gained a valuable growth mindset that has allowed her to become a more resilient individual and create attainable goals.

Even though this year was not picture perfect for these students, they found ways to make it work for them. They were able to overcome many hurdles that were passed their way through the pandemic, and instead of giving up, they excelled and pushed forward toward their goals of success.

Written byMariela Lozano, School of Molecular Sciences communications assistant,mariela.lozano@asu.edu.

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School of Molecular Sciences students reflect on their first semester in the middle of the pandemic - ASU Now

Biochemistry

Obituary: Luis Glaser, former head of biological chemistry department, 88 – Washington University School of Medicine in St. Louis

January 22, 2021 medical

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Scientist trained in laboratory of Nobel laureates Gerty and Carl Cori

Glaser

Luis Glaser, PhD, a beloved mentor and former head of the then-Department of Biological Chemistry at Washington University School of Medicine in St. Louis, died Dec. 23, 2020, in Miami after a long illness. He was 88.

Also a director of the universitys Division of Biology & Biomedical Sciences, Glaser spent the latter years of his career, from 1986 to 2005, as executive vice president and provost at the University of Miami.

At Washington University, where he earned his PhD in biochemistry, Glaser studied in the laboratory of Nobel laureates Carl and Gerty Cori. He joined the faculty as an instructor in 1956 and rose to head of the biological chemistry department, precursor to the Department of Biochemistry and Molecular Biophysics; he held that position from 1975 to 1986. He also became director of the Division of Biology & Biomedical Sciences, in 1980. He retired from Washington University in 1986 but remained affiliated with the School of Medicine as an adjunct professor through 1989.

I feel privileged to have known Luis over many years as he moved from graduate student to faculty member to department chair and to director of DBBS, said Carl Frieden, PhD, a professor of biochemistry and molecular biophysics. His knowledge and understanding of science were remarkable. A speed reader, he was always available to discuss any problem with faculty or students as he wandered down the hall, coffee in hand.We frequently had lunch together, which not only revolved around science but also the Medical Science Training Program (MSTP), in which we were both involved in its early days and, indeed, about any topic of the day.

Glaser was born in Vienna. According to an obituary published by the University of Miami, after Austria was annexed by Nazi Germany in 1939, Glasers father, a physician, was told he could no longer practice medicine in the country. Glasers family then moved to Antwerp, Belgium, for a year, and then to Mexico City, where the future scientist grew up.

Glaser earned his bachelors degree from the University of Toronto before pursuing his doctorate and launching his career in St. Louis. He also met his wife, Ruth, at Washington University. They were married for 59 years.

He is survived by his wife; his daughters Miriam Lipsky and Nicole Glaser, and five granddaughters.

Private funeral services were held in December.

Memorial contributions may be made in Glasers memory to the charitable organization of ones choice.

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Obituary: Luis Glaser, former head of biological chemistry department, 88 - Washington University School of Medicine in St. Louis

Biochemistry

Collaboration with Homeland Security focuses on detecting biothreats – Iowa State University News Service

January 22, 2021 medical

AMES, Iowa In situations where humans are exposed to biothreats such as a virus, fast detection and response can make all the difference in mitigating harm. But the ability to detect biothreats often relies on expertise and equipment thats difficult to transport and takes time to carry out.

Researchers at Iowa State University hope to change that through a collaborative agreement with the U.S. Department of Homeland Security worth as much as $2.5 million over five years. The effort aims to develop a portable sensor platform capable of detecting numerous biothreats, such as the coronavirus and other toxic agents. Such sensors could be kept in government buildings, airports, or anywhere else at risk for biothreat exposure and could help to quickly detect and mitigate dangers, said Marit Nilsen-Hamilton, a professor in the Roy J. Carver Department of Biophysics, Biochemistry and Molecular Biology and principal investigator of the project.

Up to now weve been looking at detecting infectious viruses in people who are infected, Nilsen-Hamilton said. This is an opportunity to develop a means of detecting viruses and other biothreats in the air. In other words, wed be able to quickly identify when there is a biothreat in the surrounding environment and protect people from exposure.

The team proposes to create a device roughly the size of a shoebox that can sample the air for a range of biothreats, including Ebola virus, SARS-CoV-2 and various toxins. The technology would include a microfluidic collection device that gathers air samples and a suite of sensors to detect and identify biothreats. The device will transfer particles extracted from air samples into a liquid stream to concentrate the particles. The stream passes through an aluminum oxide membrane that contains aptamers, or nucleic acids that behave similarly to antibodies in the human immune system. The biothreat particles bind to the aptamers, which sets off an electrical signal that the sensors detect.

Researchers in Nilsen-Hamiltons laboratory will select aptamers capable of binding to the proteins of the various biothreats included in the scope of the project. Her lab has isolated and characterized eight aptamers from millions of aptamer candidates selected for previous research projects, and she said one of the challenges for this project will be finding optimal aptamers for each threat.

Todd Kingston, an assistant professor of mechanical engineering and research team member, said part of the challenge for the project comes from the wide range of biothreats the device aims to detect. The device must reliably capture and identify various particles that have dimensions ranging from a few nanometers to micrometers, a unit of measurement thats a thousand times larger.

The difference between a micrometer and a nanometer might seem insignificant under most circumstances, but, at the microscopic level where the researchers work, thats a lot of variability for one technology to handle. Kingston said the scientists are considering ways to capture a wide range of aerosolized biothreats.

The research team also includes Monica Lamm, an associate professor of chemical and biological engineering; Pranav Shrotriya, a professor of mechanical engineering; and Wendy Maury, a virologist at the University of Iowa. Shrotriya said the team intends to have a functional device by the conclusion of the collaborative agreement.

We hope to have a working device that acts as a proof of concept at the end of five years, Shrotriya said We want to make sure the device can trap different size particles as well as sense them.

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Collaboration with Homeland Security focuses on detecting biothreats - Iowa State University News Service

Biochemistry

Biochemistry Analyzers Market Size By Analysis, Key Vendors, Regions, Type and Application, and Forecasts to 2027 – NeighborWebSJ

January 22, 2021 medical

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Biochemistry Analyzers Market Size By Analysis, Key Vendors, Regions, Type and Application, and Forecasts to 2027 - NeighborWebSJ

Biochemistry

Automated Biochemistry Analyzers Market Size, Business Growth Tactics, Future Strategies, Competitive Outlook and Forecast to 2027 Jumbo News – Jumbo…

January 22, 2021 medical

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Automated Biochemistry Analyzers Market Size, Business Growth Tactics, Future Strategies, Competitive Outlook and Forecast to 2027 Jumbo News - Jumbo...

Biochemistry

Fully Auto Biochemistry Analyzer Market: Technological Advancement & Growth Analysis with Forecast to 2025 NeighborWebSJ – NeighborWebSJ

January 22, 2021 medical

Data available with Market Study Report, LLC, regarding Fully Auto Biochemistry Analyzer Market unveils a succinct analysis of the market size, regional spectrum and revenue forecast about the Fully Auto Biochemistry Analyzer market. Furthermore, the report points out major challenges and latest growth plans embraced by key manufacturers that constitute the competitive spectrum of this business domain.

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Biochemistry

NAU chemistry professor discusses her work on vaccines for HPV, HIV, opioid addiction (VIDEO) – NAU News

January 22, 2021 medical

Is it possible to have a vaccine to prevent HIV or treat opioid addiction? Naomi Lee, an assistant professor of chemistry and biochemistry at NAU, believes it is, and her research is focused on that goal.

At a time when talk of vaccines is focused on the speed of the development and distribution of the COVID-19 vaccine, Lees work is different; her team is building a foundation of these long-standing conditions that have plagued people for decades. She has focused particularly on diseases that disproportionately affect Native Americans.

The vaccines were developing are in the very early stages among a small research group vs. the COVID-19 vaccines being developed at large pharmaceutical companies with many researchers across the world, Lee said. In addition, the COVID-19 vaccines were developed quickly due to the advancements made over the years towards other coronaviruses and mRNA vaccine technology.

Learn more about her work in this March 2020 video from NAU-TV.

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NAU chemistry professor discusses her work on vaccines for HPV, HIV, opioid addiction (VIDEO) - NAU News