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Collective Efforts to Increase Diversity, Equity, and Inclusion in the Genetics Department Make Steady Progress – Yale School of Medicine

Every two weeks, members of the Yale Genetics Diversity Advisory Committee (DAC) come together to discuss ways to address equity and inclusion across all underrepresented memberships within the department. These discussions are centered around four major areas: i) understanding the challenges that members of our community from underrepresented backgrounds face, ii) scrutinizing and formalizing a more equitable approach to hiring, iii) educating members of the community at all career stages and job functions in how to eliminate current exclusionary practices, and iv) investing in the support and retention of underrepresented minorities within the department. The committee operates within a network of Yale-wide diversity, equity, and inclusion (DEI) efforts led by Deputy Dean and Chief Diversity Officer Dr. Darin Lattimore together with Associate Dean of Diversity and Inclusion & Associate Chief Diversity Officer Rochelle Smith, both from the Yale School of Medicines Office of Diversity, Equity, and Inclusion.

DAC was formed in October 2020 and is led by the Vice Chair of Diversity in the department, Dr. Valentina Greco. The overarching goal of DAC is to provide a lens through which to scrutinize and improve all departmental practices to embrace, enrich, and support a greater diversity within the departmental membership. The committee members partner closely with departmental members and leadership to achieve this. DAC members also act as representatives for other community members at their professional level undergraduate, post-graduate, graduate students, post-doc, administrative staff and lab professionals, clinical staff, and junior and senior faculty updating their peers on DAC efforts and bringing forth the concerns of their circles to the committee. Committee members communicate regularly with each other through a Slack platform, educating themselves and supporting each other in this critical work. The committee members are individuals with diverse backgrounds and different lived experiences who must be brave, vulnerable, and open with each other as they discuss the resistance within and outside the community to implement cultural change.

One of the areas where DAC is currently focusing its efforts on is the departments hiring practices, closely collaborating with faculty members and departmental leadership to develop an approach that both attracts and enriches for diverse memberships. To this end, DAC has recently provided extensive review and feedback of departmental guidelines for the recruitment of new junior faculty. These guidelines span from the initial wording of the advertisement to procedures detailing best practices for scoring applications, conducting interviews, and advancing candidates at each stage of review. Once approved, the guidelines will help to ensure that diversity is embedded in every faculty search going forward as a core value of the department, and that proactive steps to promote diversity in faculty hiring are consistently taken, regardless of who is directing the search.

Just as important as diversifying the candidate pool is ensuring that the department can support and retain its diverse faculty members. On its own, recruiting diverse candidates will not fix problems of equity and inclusion in the department this would only perpetuate such problems by creating a false sense that the culture has become more inclusive and supportive simply through diverse recruitment efforts, instead of addressing the underlying barriers that have traditionally excluded diverse members in the first place. To provide an authentically supportive environment for vulnerable memberships within the department, DAC is helping to implement an infrastructure for everyday processes, ranging from mentoring to promotion criteria, that continually scrutinizes and improves itself to be equitable for everyone.

DAC meetings create intentional spaces for scrutiny and to brainstorm solutions. However, it is also important to note that efforts to address inequity have been underway in the department even before the formation of DAC. In 2019, Dr. Caroline Hendry, Scientific Director and Advisor to the Chair of Genetics, spearheaded the Program to Support and Retain Women Faculty in Genetics, partnering with long-time advocate of gender equity Dr. Valentina Greco, as well as senior women faculty in the department Dr. Lynn Cooley, Dr. Valerie Reinke, and Dr. Hui Zhang. The program was designed in consultation with Dr. David Berg, Clinical Professor of Psychiatry and an expert in organizational behavior and group and intergroup relations. The program takes a holistic approach to both support the professional advancement of women faculty in Genetics and to begin to break down the socio-cultural barriers that have impeded their advancement thus far. The Program to Support and Retain Women Faculty in Genetics has equipped me with tools to develop my managerial skills on a more personalized basis, says Dr. Kaelyn Sumigray, Assistant Professor of Genetics. She shares that the program provided a much-needed support system for developing my research program at a critical time in my career. The program spans four key areas: i) creating opportunities for women to become leaders, ii) scrutinizing and reassigning the distribution of burden and invisible labor in the department, iii) deconstructing gender stereotypes that limit career progression, and iv) establishing best practices for life-work integration. Importantly, the program includes men in the department insofar as they must be willing to take an active role in recognizing and addressing their privilege and role in perpetuating the structural, cultural and organizational barriers that have so far restricted womens careers in science from advancing on par with their male colleagues. Many aspects of the program can and are applied to other groups that are currently underrepresented in the department not just women in order to support and retain all vulnerable memberships.

More recently, the committee has expanded its efforts in training and educating the department on topics primarily at the intersection of race and genetics and issues of discrimination. The Equity Journal Club (EJC) was established by the departments trainees and staff in response to the social movement that came from the murder of George Floyd. It is another example of a diversity initiative that existed prior to DAC, and DAC is now working to expand the initiative and incorporate it into the more routine Research in Progress forum in the department as part of the departments ongoing educational mission. It is a sign of our commitment to learn and improve as a collective group," says Maria Benitez, a Genetics student and DAC representative. The DAC and EJC are in the midst of planning speaker events open to the Yale community to expand the conversation around the intersection of racism, genetic research, and health equity. DAC members also have a vision of putting together a library, compiling literature on anti-racism and systemic discrimination that anyone can access to educate themselves.

Dismantling structural bias and discrimination against people of diverse racial and ethnic groups, persons with disabilities, the LGBTQ+ community, people from low socioeconomic backgrounds, and other vulnerable memberships is a long-term project. It cannot be solved by one individual leader, but requires peers to unite as followers of a movement that collectively desires and is willing to make the effort for change. Dr. Greco emphasizes the need for each member in the Yale Genetics community to bring a dedicated and serious commitment to change ourselves in order to make space for others. The exceptionalism and individualism that academia is built on is antithetic to the notion that talent is widespread. Furthermore, consciously or unconsciously, we perpetuate with our actions the false belief that talent can only be found in the few memberships consistent with the appearances of those who currently hold the most power and privilege, Greco continues. DAC believes that this ideological disconnect is the biggest resistance that the department faces in moving forward with DEI initiatives. Members of the department must realize that talent is present in groups that have historically and continue to be only tolerated, suppressed, or entirely excluded at various levels on the academic ladder.

Yale Genetics DAC and members of DEI committees across Yale continue to reflect on privilege and take action to make the department and the institution a more equitable place. Though there is still so much to be done, with the ongoing activism of DAC members and the collaboration of the entire department, Yale Genetics is determined to build a more inclusive environment for all.

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Collective Efforts to Increase Diversity, Equity, and Inclusion in the Genetics Department Make Steady Progress - Yale School of Medicine

Dr. Kevin Cavanaugh to speak on Peterson Corn Genetics on Saturday – The Times

Friday, August 27, 2021 4:00 AM

Dr. Kevin Cavanaugh, President of Peterson Corn Genetics, based in Story City, IA and relocated to Cicero, will speak at this Saturdays meeting of the Cicero Kiwanis Club.

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Dr. Kevin Cavanaugh to speak on Peterson Corn Genetics on Saturday - The Times

The Bat Elixir: Geneticists Suspect that the Flying Mammal Holds the Key to Extended Healthy Life | The Weather Channel – Articles from The Weather…

A bat in flight.

Bats have developed a pretty bad rap sheet in the last few years. First, pop culture painted these mammals as a form of the blood-sucking Dracula, and then they were villainised for allegedly triggering a pandemic. Indeed, these poor creatures can't seem to catch a break! Aside from being adorable, bats have several other redeeming qualities like being the only mammals capable of flying and finding food even in complete darkness.

Of late, experts in genetics have uncovered a few startling facts about these Chiropterans, which could imply that they may hold the secret to healthy ageing. With the COVID-19 pandemic turning the spotlight on bats, their unique ability to stay alive against unmatched odds has also come under scrutiny.

The relationship between the size of a mammal, its metabolism, and lifespan is relatively straightforward. The larger the mammal, the slower its metabolism is, and this means a longer lifespan. While we humans ourselves are an exception to this rule, these flying mammals also deviate from this trend.

Some bats are known to live for 40 yearsthat's eight times longer than the lifespan of other animals their size! This unusually long lifespan of bats has always aroused the curiosity of scientistsit prompted them to ask the question, what was it that made these bats live longer?

The gene expression pattern in bats is very unique and has been associated with DNA repair, autophagy, immunity and tumour suppression, ensuring an extended health span for bats. Now, scientists are wondering if we could replicate a few such attributes on humans as well!

There's a cap-like structure called the telomere present at the end of each chromosomea microscopic threadlike part of the cell that carries part or all of the genetic material. This unique structure protects your chromosomes from damage. Every time your cells replicate, the chromosome loses just a little bit of the telomere. As time passes, this telomere gets very short, and either rides the wave of ageing or causes the cell to self-destruct. To put it succinctly, the shortening of your telomeres is why you age.

While this seems inevitable, studies conducted in the last few years revealed that the telomeres do not shorten in long-lived species of batslike the Myotis genus. This means that these species can protect their DNA for an unusually long-time in their lifespan.

A bat pup.

It's common knowledge that in humans, the body's ability to heal and repair any damage decreases considerably as we age. But researchers studied the genome of young, middle-aged, and old bats and found that their ability to repair DNA and damage caused by age increased as they grew older.

Another quality that contributes to their longevity is their ability to control their immune responses. With an over-excited immune response, humans tend to succumb to infections like COVID-19 quicker. In COVID-19 patients with regulated immune responses, the risk of ending up on the ventilator is much lower, reveals research.

Similarly, a controlled immune response could be why bats are able to carry numerous deadly pathogens like the coronavirus without succumbing to them easily.

Humans and bats have many similar genes but with a tweak here and a nip there. So, if we could someday discover what factors elicit these controlled immune responses and telomere shortening avoidance in bats and replicate it in humans, it would be a massive leap towards the utopian dream of a healthy, long life!

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The Bat Elixir: Geneticists Suspect that the Flying Mammal Holds the Key to Extended Healthy Life | The Weather Channel - Articles from The Weather...

Dasa expands partnership with SOPHiA GENETICS for the first decentralized cancer biomarker detection solution in Latin America – PRNewswire

SO PAULO, Brazil and BOSTON, Aug. 24, 2021 /PRNewswire/ -- Dasa, the largest integrated healthcare network in Brazil, has chosen to expand upon its partnership with SOPHiA GENETICS SA (Nasdaq: SOPH) to offer the first decentralized HRD (Homologous recombination deficiency) analytics solution in Latin America. HRD is a complex biomarker, important for PARP inhibitors, that helps identify whether cancer patients may respond better to specific treatments, and its use could ultimately lead to personalized therapies that benefit the individual patient.

Renowned in Brazil and abroad, Dasa serves more than 20 million patients per year including approximately 10% of the Brazilian population - through its more than 250,000 medical partners comprised of more than 59 diagnostic medicine brands and hospitals. With the help of the knowledge pooling SOPHiA DDMTM platform, Dasa has drawn further insights upon the many complex molecular datasets that they analyze for the benefit of their patients.

Today's announcement further builds on the partnership that began between the two companies in 2016, when Dasa chose SOPHiA GENETICS to build the original workflow for its genomics lab. This partnership further evolved when Dasa implemented SOPHiA DDMTMRadiomics and Trial Match solutions in 2020 to create the first multimodal approach in the region.For half a decade, the two companies have pioneered new ways to enable scalability and high output screening on complex assays, shortening the path from research to consumer applications and more.

"SOPHiA GENETICS' decentralized approach gives us automated and reproducible results in-house. Their expert bioinformatics team got us up and running on our own, helping us save considerable time, gain efficiency, and offer a more affordable solution for patients," said Gustavo Riedel, Business Director for Genomics and LATAM Clinical Research at Dasa.

"Dasa initially wanted to be able to track the entire diagnostic journey for their cancer patients. With such a large regional network, this is a task that's not unlike navigating an ocean of data through a hurricane. Through our past collaborations and now the addition of our decentralized HRD solution - SOPHiA GENETICS is able to act as the lighthouse that guides Dasa through the storm as they make new discoveries, helping both short and long-term patient care," said Jurgi Camblong, Co-founder and CEO of SOPHiA GENETICS.

To learn more about how SOPHiA GENETICS data-driven insights are improving diagnosis, treatment and drug development for patients and the larger medical community, visit sophiagenetics.com.

About SOPHiA GENETICS:SOPHiA GENETICS is a healthcare technology company dedicated to establishing the practice of data-driven medicine as the standard of care and for life sciences research. It is the creator of the SOPHiA DDM Platform, a cloud-based SaaS platform capable of analyzing data and generating insights from complex multimodal data sets and different diagnostic modalities. The SOPHiA DDM Platform and related solutions, products and services are currently used by more than 780 hospital, laboratory, and biopharma institutions globally.

More info:SOPHiAGENETICS.COM; follow@SOPHiAGENETICSon Twitter

About Dasa:Dasa is the largest integrated healthcare network in Brazil, serving more than 20 million people a year, with high technology, intuitive experience and an attitude ahead of time. With more than 40 thousand employees and 250 thousand partner doctors, Dasa is the healthcare solution that people want and that the world needs, being present at every stage of care.

Dasa believes that in order to take care, it is always necessary to take care fully. Therefore, it looks at health management in a preventive, predictive and personalized way. It integrates diagnostic medicine, hospitals, genomics, oncology, care coordination, emergency care, telemedicine, clinical research and science. In all, it has 15 reference hospitals (considering its own network, inorganic growth and deals that are still under regulatory approval), and more than 59 brands including diagnostic medicine and hospitals, distributed in more than 900 units in Brazil.

Dasa guarantees agile, uncomplicated and friction-free navigation of the health journey, for both patients and physicians through its management platform, Nav. In addition, it offers integrated and innovative corporate health solutions through Dasa Empresas. We are Dasa and we are for life. For more information, access: http://www.dasa.com.br.

Contact: [emailprotected]

SOURCE SOPHiA GENETICS

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Dasa expands partnership with SOPHiA GENETICS for the first decentralized cancer biomarker detection solution in Latin America - PRNewswire

Genetic Analyses Trace How Mutations Accumulate in Cells of the Human Body Over Time – GenomeWeb

NEW YORK A suite of new studies has examined how one cell develops into all the tissues of the human body by tracing and investigating the mutations they acquire over time.

As cells divide, they acquire mutations that are then passed on to their daughter cells. The resulting patterns of mutations can be used to trace back a cell's family tree, possibly all the way to the first cell. In four new studies appearing Wednesday in Nature, teams of researchers from across the world used this approach to study the earliest stages of human development as well as the later accumulation of somatic mutations, including ones linked to cancer.

"Exploring the human body via the mutations cells acquire as we age is as close as we can get to studying human biology in vivo," Luiza Moore, a researcher at the Wellcome Sanger Institute and first author of one of the studies, said in a statement. "Our life history can be found in the history of our cells, but these studies show that this history is more complex than we might have assumed."

Tracing these mutations back in time revealed differences in mutation rates very early in embryonic development. Researchers led by the Sanger Institute's Michael Stratton uncovered a pattern of mutations that indicated a high initial mutation rate that then fell in a study that combined laser capture microdissections with whole-genome sequencing of samples from three individuals. A team led by the Korea Advanced Institute of Science and Technology's Young Seok Ju similarly found a high mutational rate during the early stages of development that then declined, using a capture-recapture approach.

The Stratton-led team estimated that the first two cell divisions had mutation rates of 2.4 per cell per generation, which then fell to 0.7 per cell per generation. This dip, they said, is likely due to the activation of the zygotic genome that increases the ability to repair DNA.

These early cells also contributed unequally to the development of subsequent lineages, though the degree of asymmetry varied from person to person. Ju and his colleagues reported, for instance, that for one individual in their analysis, 112 early lineages split at a ratio of 6.5:1, rather than the expected 1:1.

Stratton and his colleagues, meanwhile, reported that one individual in their study had a 69:31 contribution of the initial daughter cells to subsequent lineages, while another had a 93:7 ratio based on bulk brain samples, but an 81:19 ratio based on colon samples.

This, they said, indicates that the lineage commitment of cells is not fixed. Ju and his colleagues likewise said their finding suggested a stochasticity of clonal segregation in humans, unlike the deterministic embryogenesis observed in C. elegans.

These analyses also shed light on the development of somatic mutations later in life. KAIST's Ju and his colleagues, for instance, found most mutations are specific to certain clones, while in a separate study, the Sanger's Moore and her colleagues, who examined the mutational landscape of 29 cell types from three individuals through sequencing, found mutationrates varied by cell type and were very low in spermatogonia.

Ju and his colleagues also reported that normal tissues harbored known mutational signatures, including UV-mediated DNA damage and endogenous clock-like mutagenesis. Similarly, Moore and her colleagues noted known mutational signatures within normal tissues. They found, for instance, the aging-related SBS1 and SBS5 mutational signatures to be the most common signatures across all cell types, while other signatures were more prominent in certain cell types but not others. The SBS88 signature, which is due to a strain of E. coli, for example, was present among colorectal and appendiceal crypts.

Chen Wu, an investigator at the Chinese Academy of Medical Sciences, and her colleagues also found the aging-related SBS1 and SBS5 mutational signatures to be common among normal tissues, based on their sequencing analysis of microbiopsies from five individuals. Other tissues, like the liver and lung, also harbored other mutational signature like SBS4, which is associated with tobacco smoking.

Some of the mutations present in normal somatic tissues are typically associated with cancer, Wu and her colleagues added. They found mutations in 32 cancer driver genes were widespread among their normal tissue samples, though varied by organ. For instance, driver mutations were present in 6.5 percent of pancreas parenchyma samples and in 73.8 percent of esophageal samples.

Additionally, many normal tissue samples harbored as many as three cancer driver mutations. This, Harvard Medical School's Kamila Naxerova noted in a related commentary in Nature, begins to blur the line between what is normal and what is cancer. "Indeed, if cells with three driver mutations can easily be found in a small tissue sample, cells with four or five drivers probably exist in that tissue as well without necessarily giving rise to cancer," she wrote. "These new insights invite us to reconsider how we genetically define cancer."

Overall, she added that "the four studies provide an impressive demonstration of the power of modern genetics to decode the cellular dynamics that unfold in our bodies over time."

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Genetic Analyses Trace How Mutations Accumulate in Cells of the Human Body Over Time - GenomeWeb

Study Finds Genetics Rather Than Environment Are Source of THC Levels in Hemp – AgNet West

A recent study from Cornell University has found no link between increases in the THC content in hemp with environmental or biological stresses. Guidelines from USDAs Agricultural Marketing Service note that the threshold for THC content is 0.3 percent. USDA has recently raised what it considers to be a negligent crop from THC levels of .5 percent to one percent, reducing some risk for growers. Senior author of the study and professor in the horticulture section of the School of Integrative Plant Science in the College of Agriculture and Life Sciences, Larry Smart said that their findings should help to provide some comfort regarding the CBD to THC ratio in hemp.

Theresearch projectincluded control plots and five stress treatments that were applied to three genetically unrelated high-CBD hemp cultivars. The stress treatments included flood conditions, physical wounding, exposure to a particular plant growth regulator, powdery mildew, and herbicide. Over the four-week maturation period, tests showed that THC content increased proportionally for all of the different stress treatments imposed on the different cultivars. The study provides support for genetics being the determining factor for THC content in hemp plants rather than environmental stresses. Further research and breeding will be needed to better determine the appropriate genetics for achieving a high CDB content with acceptable levels of THC.

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Study Finds Genetics Rather Than Environment Are Source of THC Levels in Hemp - AgNet West

Department of Physiology and Biophysics Seminar – umc.edu

Main Content

When: Wednesday, September 01, 2021, from 12:00 p.m. to 1:00 p.m.Location: WebEx

Contact Info: Courtney Graham at chortongraham@umc.edu or 601-984-1820Related Link: Click here to view event flyer

Dr. Jennifer Sones, Associate Professor of Theriogenology in the Department of Physiology/ School of Medicine, will give the virtual Department of Physiology and Biophysics Seminar, Metabolic Basis of Disease in BPH/5 Mice, at noon on Wednesday, Sept. 1, online via WebEx.

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Department of Physiology and Biophysics Seminar - umc.edu

New imaging, machine-learning methods speed effort to reduce crops’ need for water – University of Illinois News

CHAMPAIGN, Ill. Scientists have developed and deployed a series of new imaging and machine-learning tools to discover attributes that contribute to water-use efficiency in crop plants during photosynthesis and to reveal the genetic basis of variation in those traits.

The findings are described in a series of four research papers led by University of Illinois Urbana-Champaign graduate students Jiayang (Kevin) Xie and Parthiban Prakash, and postdoctoral researchers John Ferguson, Samuel Fernandes and Charles Pignon.

The goal is to breed or engineer crops that are better at conserving water without sacrificing yield, said Andrew Leakey, a professor of plant biology and of crop sciences at the University of Illinois Urbana-Champaign, who directed the research.

Drought stress limits agricultural production more than anything else, Leakey said. And scientists are working to find ways to minimize water loss from plant leaves without decreasing the amount of carbon dioxide the leaves take in.

Plants breathe in carbon dioxide through tiny pores in their leaves called stomata. That carbon dioxide drives photosynthesis and contributes to plant growth. But the stomata also allow moisture to escape in the form of water vapor.

A new approach to analyzing the epidermis layer of plant leaves revealed that the size and shape of the stomata (lighter green pores) in corn leaves strongly influence the crops water-use efficiency.

Micrograph by Jiayang (Kevin) Xie

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The amount of water vapor and carbon dioxide exchanged between the leaf and atmosphere depends on the number of stomata, their size and how quickly they open or close in response to environmental signals, Leakey said. If rainfall is low or the air is too hot and dry, there can be insufficient water to meet demand, leading to reduced photosynthesis, productivity and survival.

To better understand this process in plants like corn, sorghum and grasses of the genus Setaria, the team analyzed how the stomata on their leaves influenced plants water-use efficiency.

We investigated the number, size and speed of closing movements of stomata in these closely related species, Leakey said. This is very challenging because the traditional methods for measuring these traits are very slow and laborious.

For example, determining stomatal density previously involved manually counting the pores under a microscope. The slowness of this method means scientists are unable to analyze large datasets, Leakey said.

There are a lot of features of the leaf epidermis that normally dont get measured because it takes too much time, he said. Or, if they get measured, its in really small experiments. And you cant discover the genetic basis for a trait with a really small experiment.

To speed the work, Xie took a machine-learning tool originally developed to help self-driving cars navigate complex environments and converted it into an application that could quickly identify, count and measure thousands of cells and cell features in each leaf sample.

Jiayang (Kevin) Xie converted a machine-learning tool originally designed to help self-driving cars navigate complex environments into an application that can quickly analyze features on the surface of plant leaves.

Photo by L. Brian Stauffer

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To do this manually, it would take you several weeks of labor just to count the stomata on a seasons worth of leaf samples, Leakey said. And it would take you months more to manually measure the sizes of the stomata or the sizes of any of the other cells.

The team used sophisticated statistical approaches to identify regions of the genome and lists of genes that likely control variation in the patterning of stomata on the leaf surface. They also used thermal cameras in field and laboratory experiments to quickly assess the temperature of leaves as a proxy for how much water loss was cooling the leaves.

This revealed key links between changes in microscopic anatomy and the physiological or functional performance of the plants, Leakey said.

By comparing leaf characteristics with the plants water-use efficiency in field experiments, the researchers found that the size and shape of the stomata in corn appeared to be more important than had previously been recognized, Leakey said.

Along with the identification of genes that likely contribute to those features, the discovery will inform future efforts to breed or genetically engineer crop plants that use water more efficiently, the researchers said.

The new approach provides an unprecedented view of the structure and function of the outermost layer of plant leaves, Xie said.

There are so many things we dont know about the characteristics of the epidermis, and this machine-learning algorithm is giving us a much more comprehensive picture, he said. We can extract a lot more potential data on traits from the images weve taken. This is something people could not have done before.

Leakey is an affiliate of the Carl R. Woese Institute for Genomic Biology at the U. of I. He and his colleagues report their findings in a study published in The Journal of Experimental Botany and in three papers in the journal Plant Physiology (see below).

The National Science Foundation Plant Genome Research Program, the Advanced Research Projects Agency-Energy, the Department of Energy Biosystems Design Program, the Foundation for Food and Agriculture Research Graduate Student Fellows Program, The Agriculture and Food Research Initiative from the U.S. Department of Agriculture National Institute of Food and Agriculture, and the U. of I. Center for Digital Agriculture supported this research.

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New imaging, machine-learning methods speed effort to reduce crops' need for water - University of Illinois News

Awards and Honors Across Weill Cornell Medicine August 27, 2021 – Weill Cornell Medicine Newsroom

Dr. Dolores Lamb, who was recruited as assistant professor of molecular biology in urology, has been elected Eastern Regional Administrative Secretary at the American Association of Bioanalysts (AAB) as a member of the AAB Membership Review Committee. Dr. Lambs term began in June 2021.

Dr. Christopher Mason, co-director of theWorldQuant Initiative for Quantitative Predictionand a professor of physiology and biophysics, has been selected to serve on the National Academy of Sciences (NAS) Committee to develop the next 10 years of NASA and space medicine priorities.

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Awards and Honors Across Weill Cornell Medicine August 27, 2021 - Weill Cornell Medicine Newsroom

Neurological manifestations of COVID-19 in patients: from path physiology to therapy – DocWire News

This article was originally published here

Neurol Sci. 2021 Aug 21. doi: 10.1007/s10072-021-05505-7. Online ahead of print.

ABSTRACT

Coronavirus is a family of ARN positive single-stranded belonging to the family of Coronaviridae. There are several families of coronavirus that transmit more or less serious diseases. However, the so-called coronavirus-19 (SARS-CoV2) is the one that is currently causing most of the problems; in fact, biological dysfunctions that this virus causes provoke damage in various organs, from the lung to the heart, the kidney, the circulatory system, and even the brain. The neurological manifestations caused by viral infection, as well as the hypercoagulopathy and systemic inflammation, have been reported in several studies. In this review, we update the neurological mechanisms by which coronavirus-19 causes neurological manifestation in patients such as encephalomyelitis, Guillain-Barr syndrome, lacunars infarcts, neuropsychiatry disorders such as anxiety and depression, and vascular alterations. This review explains (a) the possible pathways by which coronavirus-19 can induce the different neurological manifestations, (b) the strategies used by the virus to cross the barrier system, (c) how the immune system responds to the infection, and (d) the treatment than can be administered to the COVID-19 patients.

PMID:34417704 | DOI:10.1007/s10072-021-05505-7

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Neurological manifestations of COVID-19 in patients: from path physiology to therapy - DocWire News