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Researchers Develop Next-Gen Cancer Therapy – University of Houston

Oncolytic viruses are those that can kill cancer cells while leaving nearby healthy cells and tissues intact. Image of cancer cells courtesy: GettyImages

Shaun Zhang, director of the Center for Nuclear Receptors and Cell Signaling at the University of Houston and M.D. Anderson Professor in the Department of Biology & Biochemistry, has created a new oncolytic virus, pushing oncolytic cancer therapy forward.

Among the most promising anti-cancer treatments in recent years, oncolytic virotherapy (OV) has emerged at the top of the pack of immunotherapy. Oncolytic viruses are those that can kill cancer cells while leaving nearby healthy cells and tissues intact. In oncolytic virotherapy, the treatment also exerts its influence by activating an antitumor immune response made of immune cells such as natural killer (NK) cells.

But sometimes those natural killers limit the oncolytic viruses, and so despite the exciting development in the OV field in recent years, there is room for improvement to tackle some limitations, including the relatively weak therapeutic activity and lack of means for effective systemic delivery.

Those improvements are now being made in the lab of Shaun Zhang, director of the Center for Nuclear Receptors and Cell Signaling at the University of Houston and M.D. Anderson Professor in the Department of Biology & Biochemistry. Zhang has received a $1.8 million grant from the National Institutes of Health to support his work.

We have developed a novel strategy that not only can prevent NK cells from clearing the administered oncolytic virus, but also goes one step further by guiding them to attack tumor cells. We took an entirely different approach to create this oncolytic virotherapy by deleting a region of the gene which has been shown to activate the signaling pathway that enables the virus to replicate in normal cells, said Zhang.

The different approach consists of Zhangs lab creating a new oncolytic virus called FusOn-H2, based on the Herpes simplex 2 virus, (HSV-2, commonly known as genital herpes). Its the first of its kind. They arm the virus with a NK cell engager, resulting in what Zhang calls the two birds with one stone strategy to enhance therapeutic effect of the new oncolytic virus. This engager forms a bridge between NK cells and tumor cells, resulting in the killing of the engaged tumor cells.

Our recent studies showed that arming FusOn-H2 with a chimeric NK engager (C-NK-E) that can engage the infiltrated natural killer cells with tumor cells could significantly enhance the effectiveness of this virotherapy, said Zhang. Most importantly, we observed that tumor destruction by the joint effect of the direct oncolysis and the engaged NK cells led to a measurable elicitation of neoantigen-specific antitumor immunity.

Zhang and team believe that this armed FusOn-H2 will produce a three-pronged effect to enhance the antitumor efficacy against solid tumors in colon and lung cancer, which they expect to come in waves.

The first wave comes immediately after the armed virus is administered and it derives primarily from administration of the virus. The second wave comes from the natural killer cells doing their work while the third wave is the outcome of a series of chain events that ultimately result in inducing neoantigen-specific antitumor immunity.

We hypothesize that the combination of the high potency of the three-pronged therapy with the improved systemic delivery will lead to effective treatment of metastatic diseases, said Zhang.

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Researchers Develop Next-Gen Cancer Therapy - University of Houston

Researchers use rapid antibody test to gauge immune response to SARS-CoV-2 variants – University of Toronto

COVID-19 infections are once again on the rise as our immune systems struggle to combat new variants.

Thats according to a University of Toronto study that foundthe antibodies generated by people who were vaccinated and/or recovered from COVID-19prior to 2022 failed to neutralize the variants circulating today.

Furthermore, the researchers expect that the antibody test they developed to measure immunity in the studys participants will become a valuable tool for deciding who needs a booster and when,helping to save lives and avoid future lockdowns.

The truth is we dont yet know how frequent our shots should be to prevent infection, saidIgor Stagljar, a professor of biochemistry and molecular geneticsat theDonnelly Centre for Cellular and Biomolecular Research andat the Temerty Faculty of Medicine. To answer these questions, we need rapid, inexpensive and quantitative tests that specifically measure Sars-CoV-2 neutralizing antibodies, which are the ones that prevent infection.

The study was led byStagljarand Shawn Owen, an associate professor of pharmaceutics and pharmaceutical chemistry, at the University of Utah.

The journalNature Communications recentlypublished their findings.

Many antibody tests have been developed over the past two years. But only a few of the authorized ones are designed to monitor neutralizing antibodies, which coat the viral spike protein so that it can no longer bind its receptor and enter cells.

It's an important distinction, as only a fraction of all Sars-CoV-2 antibodies generated during infection are neutralizing. And while most vaccines were specifically designed to produce neutralizing antibodies, its not clear how much protection they give against variants.

Our method, which we named Neu-SATiN, is as accurate as but faster and cheaper than the gold standard, and it can be quickly adapted for new variants as they emerge, Stagljar said.

Neu-SATiN stands forNeutralizationSerologicalAssay based on splitTri-partNanoluciferase, and it is a newer version ofSATiN, which monitors the complete IgG poolthey developed last year.

The development of Neu-SATiN was spearheaded byZhong Yao, a senior research associate in Stagljars lab, and Sun Jin Kim, a post-doctoral researcherin Owens lab, who are the co-first authors on the paper.

The pinprick test is powered by the fluorescent luciferase protein from a deepwater shrimp. It measures the binding between the viral spike protein and its human ACE2 receptor, each of which is attached to a luciferase fragment. The engagement of the spike protein with ACE2 pulls the fragments close, catalyzing reconstitution of the full length luciferasewith a concomitant glow of light captured by the luminometer instrument. When a patients blood sample is added into the mixture, the neutralizing antibodies bind to and mop up all spike protein, while ACE2 remains in unengaged state. Consequentially, the luciferase remains in piecesand the light signal drops. The researchers say the plug-and-play design of the test means it can be adapted to emerging variants by engineering mutations in the spike protein.

The researchers applied Neu-SATiN to blood samples collected from 63 patients with different histories of COVID-19 and vaccinationup to November 2021. Patient neutralizing capacity was assessed against the original Wuhan strainand the following variants:Alpha, Beta, Gamma, Delta and Omicron.

We thought it would be important to monitor people that have been vaccinated to see if they still have protection and how long it lasts, said Owen, who did his post-doctoral training in the Donnelly Centre with distinguished bioengineer and University Professor Molly Shoichet of the Faculty of Applied Science & Engineering.But we also wanted to see if you were vaccinated against one variant, does it protect you against another variant?

The neutralizing antibodies were found to last about three to four months beforetheir levels would drop by about 70 per cent irrespective of infection or vaccination status. Hybrid immunity, acquired through both infection and vaccination, produced higher antibody levels at first, but these too dropped significantly four months later.

Most worryingly, infection and/or vaccination provided good protection against the previous variants, but not Omicronor its sub-variantsBA.4 and BA.5.

The data match those from arecent U.K. study thatshowed that both neutralizing antibodies and cellular immunity a type of immunity provided by memory T cellsfrom either infection, vaccination, or both, offered no protection from catching Omicron. In a surprising twist, the U.K. group also found that infections with Omicron boosted immunity against earlier strains, but not against Omicron itselffor reasons that remain unclear.

It's important to stress that vaccines still confer significant protection from severe disease and death, said Stagljar. Still, he added that the findings from his team and others call for vigilance in the coming periodgiven that the more transmissible BA.4 and BA.5 sub-variants can escape immunity acquired from earlier infections with Omicron, as attested by rising reinfections.

There will be new variants in the near future for sure, Stagljar said. Monitoring and boosting immunity with respect to circulating variants will become increasingly important and our method could play a key role in this since it is fast, accurate, quantitative and cheap.

He is already collaborating with the Canadian vaccine maker Medicago to help determine the efficacy of their candidates against Omicron and its sub-variants.Meanwhile, U of T is negotiating to license Neu-SATiN to a company which will scale it up for real world usessuch as population immunosurveillance and vaccine development.

The research was supported with funding from the Toronto COVID-19 Action Fund,Division of the Vice-President, Research & Innovation and the 3i Initiative at the University of Utah.

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Researchers use rapid antibody test to gauge immune response to SARS-CoV-2 variants - University of Toronto

Clemson research could advance key understanding of cell mutation, pave way to new cancer treatments – Greenville Journal

A number of Clemson University research projects are designed to advance critical understanding of how cancer cells function, but one project seeks to unlock some of the mysteries behind the most common type of cancer and lead to more effective treatments.

Jennifer Mason, assistant professor of genetics and biochemistry and a researcher in Clemsons Center for Human Genetics, has received more than $2.6 million in grant funding to investigate how cells repair DNA damage and what happens when those processes go wrong.

Such breakdowns can lead to mutations, according to Mason, a process at the heart of most cancers and increasingly tied to many diseases. Her research aims to answer many important questions about a particular DNA repair protein, known as FBH1, tied to the most common form of cancer, skin cancer, and its most deadly variant, melanoma.

Cancer is a disease of mutation, Mason says. The majority of cancers have an underlying defect that causes the cells to increase their mutation rate.

Masons work is being funded in part by a $792,000 research scholar grant from the American Cancer Society. Her research was inspired by a study that found missing or defective FBH1 in a majority of melanoma cases.

DNA damage is a natural process that happens in human cells, and one of the most common causes of such damage is ultraviolet light from exposure to sunlight. UV light is a major cause for melanoma, according to the American Cancer Society, and states with a high UV index, like South Carolina, tend to have higher incidences of melanoma in their populations.

Among the aims of Masons research is to find out why missing or defective FBH1 is resistant to DNA-destroying compounds, a property at the heart of most chemotherapies. Cracking that puzzle could lead to more effective cancer treatments.

Thats the hope of where someday this research will lead, she says.

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Clemson research could advance key understanding of cell mutation, pave way to new cancer treatments - Greenville Journal

Dihydropyridine (DHP) Market Insights 2022 And Analysis By Top Keyplayers Shenzhen Simeiquan Biotechnology, Boc Sciences, Weifang Union Biochemistry,…

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How to be less judgmental on social media and in real life – Vox.com

Casting judgment on others has never been so easy. Social media gives onlookers the opportunity to scoff at a persons every choice, from how they dress to what they feed their children. How people have behaved during the pandemic has inspired plenty of judgment in its own right: At the height of restrictions, adherence or lack thereof to masking and social distancing measures practically became barometers of peoples characters, indicating a lack of personal responsibility and empathy or an abundance of hysteria and over-caution, depending on your views.

While it gets a bad rap, in pre-modern times, judgment helped keep people safe. Judgments were alarm bells allowing humans to distinguish between toxic and harmless food, trustworthy and untrustworthy tribe members, and hardworking and lazy kinspeople, explains psychologist Carla Marie Manly, author of Joy From Fear: Create the Life of Your Dreams by Making Fear Your Friend.

Judgment is also a signal that someones behavior is unusual or out of context to your particular in-group, says Adam Moore, lecturer of psychology at the University of Edinburgh, who studies judgment and decision making. The role that automatic judgment plays, Moore says, is social signaling, social norm reinforcing.

But in todays mobile, digitally facilitated world, judgment can take on new, toxic forms, Moore says. When you silently cast judgment on someone from afar based on an Instagram story, you dont get feedback from other people or even the subject of your judgment and you dont learn how to make comments or critiques in a constructive way. Normally in a social situation, you judge somebodys behavior, and their response to you helps to calibrate your interaction with them, and also the responses of other people around you, Moore says. Because so much of our lives are disconnected from each other we dont perceive that body language and we dont perceive that social feedback anymore.

Digital platforms also incite and prioritize outrage and conflict, making it easy to look down on others from your moral high horse. When people are constantly sneering at others on public platforms, the perception of what normal social judgments should look like is skewed. In normal communities and in normal, functional families, passing judgment on other peoples behavior, it functions very well, Moore says. Families rarely break up because somebody says, Hey, youre acting like a jerk at a Fourth of July party.

While judgments help signal social norms and allow us to identify our people, mean-spirited critiques are unproductive. Discernment, on the other hand, can help you identify unhealthy and toxic behaviors, Manly says. In todays polarized world, its important to detect when someones attitudes and beliefs pose a threat to others rights and well-being. Unless someones behavior is actively harming themselves or others (in which case, you should name the behavior, tell the other person how youre feeling, and set boundaries on how youd like them to act moving forward), learning to curb petty moral righteousness is possible, but requires slowing down your thoughts and having some empathy.

If youre motivated to stop hurtful critiques, you have to evaluate their source. When you feel a twang of annoyance when a friend impulsively books a vacation despite constantly complaining about money, ask yourself why youre upset by this behavior or what purpose your anger or annoyance serves in this instance. Anger is often a signal that another person isnt taking your well-being into consideration or theres a conflict, Moore explains. Does your friends last-minute trip conflict with upcoming plans the two of you have or is it simply something you wouldnt personally do?

Do I have any reason to demand that other people in this situation care more about me than whatever signal theyre trying to send? Moore says. Even if the answer to that question is yes, having to stop and think about it often turns the volume down on things.

In order to reframe judgmental thoughts, you need to catch them in the act. We have to pull back and go, Im being judgy, I dont really want to do that, Manly says. If you find yourself whispering a snide remark to your friend about a strangers shoes, try to reframe the judgment by complimenting the persons confidence, for instance. Just as being judgmental is a practiced habit, so is stopping thought patterns that lead to hurtful observations and assumptions. If we come to notice were doing something that is unhealthy and pause and stop it, then we are far less likely to go down that path, Manly says. Thats why I like compensating because if I do catch myself doing something thats comparative, rather than just noticing, I give myself other positive hits [like] look at their beautiful smile.

Manly also suggests looking back on previous moments of judgment and thinking about what you could do better next time. Recall a moment you made a judgmental remark. What was the response? Would the statement make someone feel better about themselves if they heard it? Do you feel better about yourself having remembered it? If not, allow these reflections to guide you so the next time you see someone talking on speaker phone on the subway, for example, you can instead internally marvel at their interesting phone case instead of scoffing at having to hear their entire conversation.

When people buck social conventions, those casting judgments are often quick to be offended before considering a reason why someone else is engaging in that behavior. Say your colleague is quitting their job before landing a new one and youre outraged at their irresponsibility. Instead of jumping to conclusions, get curious and ask them about their reasons for resigning or what they hope to accomplish during their time off. Curiosity is the antidote for judgment, Manly says. Manly suggests meeting those youre unjustly judging with compassion: hoping theyre happy and doing well.

When it comes to differences of opinion, it can be easy to assume that someone who doesnt share your beliefs is evil or stupid, Moore says. Instead of reacting aggressively in an attempt to change their mind, Moore suggests thinking of a good-faith reason why someone would think this way as a means to slow down the judgment process. What does the person youre judging know about their behavior or beliefs that you dont know?

For example, when it comes to relatives with differing political opinions, Moore suggests thinking about how the loved one ended up believing what they believe: the media they consume, the people they surround themselves with. I find that helps me to not make toxic judgments about other peoples motivations, he says. Its really, really easy and very, very tempting to assume that people who disagree with you about something that you believe in very strongly or have very strong beliefs about are evil or stupid.

Of course, you should never compromise on important moral and social issues, Moore says. Relationships with people whose views are antithetical to your own will have to be renegotiated and youll need to decide how to move forward if you want to maintain contact. But you can control your initial assumptions of them based on their beliefs. What function is expressing those judgments serving right now? Moore says. Am I trying to build consensus about an issue or am I just trying to wave my flag and say Im of the red tribe or the blue tribe or the green tribe?

There are very few things you can do to convince people your way of thinking and living is ideal. Save for the occasions where someones behavior is dangerous and harmful, Manly says to focus only on what you can control. We can only control our behaviors, our thoughts, and our actions.

Many human behaviors are actions signaling to others what kind of person you are or what groups you belong to, Moore says. Instead of criticizing your aunt for constantly sharing bizarre Minion memes on Facebook, consider shes just vocalizing her membership in the coalition of Minion-lovers. Understanding actions underlying meanings can help you avoid pointless arguments trying to sway someone to your side of an issue.

Instead of judging and attacking and hoping others see your way, sympathize with others reasoning for their actions, dont feed into toxic thoughts, and lead by example.

You cant make somebody value the things that you value, Moore says. All you can do is try to gently demonstrate that valuing the things that you value makes the world around you better and people will want to move there in some intellectual or moral sense.

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How to be less judgmental on social media and in real life - Vox.com

Scientists unravel the neuronal metabolism in learning and memory – News-Medical.Net

Exploring the predictive properties of neuronal metabolism can contribute to our understanding of how humans learn and remember. This key finding from a consideration of molecular mechanisms of learning and memory conducted by scientists from Russia and the U.S. has been published in Neuroscience & Biobehavioral Reviews.

The emerging trend in neuroscience is to consider the work of neurons as anticipatory and future-oriented, although this approach is not yet mainstream and features in just a few publications. In a paper entitled 'Neuronal metabolism in learning and memory: The anticipatory activity perspective,' Yuri I. Alexandrov, HSE Professor and Head of the V.B. Shvyrkov Laboratory of Psychophysiology at the Russian Academy of Sciences Institute of Psychology, and Mikhail V. Pletnikov, Professor of the Department of Physiology at the State University of New York, University at Buffalo, argue that neurons behave proactively because they strive to survive-; just as all living organisms. Neurons use microenvironmental metabolites as 'food', and neuronal impulse activity is aimed at obtaining these metabolites. Rather than responding to an incoming signal, neurons proactively trigger an influx of needed substances to the cell, such as neurotransmitters.

When a specialized set of our neurons fire together, we act to obtain a behavioral outcome, while the neurons also obtain their own micro-outcome in the form of needed metabolites. This process can be described as metabolic cooperation of cells, involving not only neurons but also glial, somatic, glandular, muscle and other cells throughout the body. This principle of how cells work is central to learning, which essentially means creating systemwide groups of metabolically cooperating cells that drive human behavior."

Yuri Alexandrov, Professor at HSE School of Psychology

The researchers note that for a long time, the 'stimulus-response' paradigm was dominant in the study of molecular mechanisms of learning and memory; it was assumed that just as the entire human body responds to environmental stimuli, neurons respond to incoming impulses which cause excitation of certain parts of the neuron's membrane. The neuron either fires or does not fire, depending on whether or not the excitation reaches a certain threshold.

Back in 1930s1970s, the Russian physiologist Peter Anokhin developed his theory of functional systems, including the concept of 'integrative activity of neurons', according to which a neuron's excitation causes intraneuronal chemical processes-; rather than a summation of local excitations on the membrane. These chemical processes lead to a neuronal spike.

Building on Anokhin's theory, his student Vyacheslav Shvyrkov and colleagues developed a systems-oriented approach to the study of neurons. However, Anokhin's understanding of the sequence of events was traditional: excitation of a neuron comes first, followed by a response.

'An important recent step in understanding how neurons work has been the idea that a neuron's anticipatory activity, rather than an external impulse, is what comes first. The neuron does not respond to incoming excitation but proactively triggers an influx of activity,' Alexandrov explains.

The authors argue that exploring systemwide intercellular metabolic cooperation as a learning mechanism could be a promising area of focus for further experimental research.

This approach, they believe, could lead to breakthroughs in studying the behavior of malignant cells and in developing new cancer treatments.

'Malignancies consist of cells that metabolically cooperate not only with their immediate environment but also with other cells in the body. We plan to conduct experimental studies to explore tumor cell responses to diametrically opposed individual behaviors, such as striving towards a desirable event or avoiding an undesirable or dangerous one. This can give us insight into how various systemwide cellular integrations impact tumor cells' survival. As a result, we hope to propose an effective approach to influencing tumor cells through human behavior, Alexandrov concludes.

Source:

Journal reference:

Alexandrov, Y.I., et al. (2022) Neuronal metabolism in learning and memory: The anticipatory activity perspective. Neuroscience & Biobehavioral Reviews. doi.org/10.1016/j.neubiorev.2022.104664.

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Scientists unravel the neuronal metabolism in learning and memory - News-Medical.Net

Pet of the Week: Smoot | Pet of the Week | thedaonline.com – The Daily Athenaeum – thedaonline

Meet Smoot! Smoot is a cute bearded dragon lizard who does a great rock impersonation. He loves to sit on his log under his heat lamp and observe his domain (the house and/or off the balcony). Nothing phases him... he is super chill and a great buddy for long car rides. Smoot is more judgmental of human behavior than any cat, always with his nose in the air. When he is feeling particularly energetic, all he wants to do is bolt around the house and/or outside while on his leash. Each time he does a spurt of running around somewhere, Smoot looks back at me to see if I'm still there. He loves to eat live bugs and the choicest fruits, but hates eating his vegetables. Smoot doesn't do any tricks, but he is (mostly) potty-trained, and everyone loves to watch him eat because he looks like a dinosaur. His favorite treat is bananas- he goes bananas for bananas. He also likes eating clover flowers and the bees that pollinate them.

Submitted by Catherine Smith.

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Pet of the Week: Smoot | Pet of the Week | thedaonline.com - The Daily Athenaeum - thedaonline

Algorithm claims to predict crime in U.S. cities before it happens – SecurityInfoWatch

A new computer algorithm can now forecast crime in a big city near you apparently.

The algorithm, which was formulated by social scientists at the University of Chicago and touts 90% accuracy, divides cities into 1,000-square-foot tiles, according to a study published in Nature Human Behavior. Researchers used historical data on violent crimes and property crimes from Chicago to test the model, which detects patterns over time in these tiled areas and tries to predict future events. It performed just as well using data from other big cities, including Atlanta, Los Angeles and Philadelphia, the study showed.

The new tool contrasts with previous models for prediction, which depict crime as emerging from hotspots that spread to surrounding areas. Such an approach tends to miss the complex social environment of cities, as well as the nuanced relationship between crime and the effects of police enforcement, thus leaving room for bias, according to the report.

It is hard to argue that bias isnt there when people sit down and determine which patterns they will look at to predict crime because these patterns, by themselves, dont mean anything, said Ishanu Chattopadhyay, Assistant Professor of Medicine at the University of Chicago and senior author of the study. But now, you can ask the algorithm complex questions like: What happens to the rate of violent crime if property crimes go up?

But Emily M. Bender, professor of linguistics at the University of Washington, said in a series of tweets that the focus should be on targeting underlying inequities rather than on predictive policing, while also noting that the research appears to ignore securities fraud or environmental crimes.

And other crime prediction models previously used by law enforcers have been found to erroneously target certain people based on a narrower set of factors. In 2012, the Chicago Police Department along with academic researchers implemented the Crime and Victimization Risk Model that produced a list of so-called strategic subjects, or potential victims and perpetrators of shooting incidents determined by factors such as age and arrest history.

The model assigned a score that determined how urgently people on the list needed to be monitored, and a higher score meant they were more likely to be perceived as either a potential victim or perpetrator of a gun crime.

But after a lengthy legal battle, a Chicago Sun-Times investigation revealed in 2017 that nearly half of the people identified by the model as potential perpetrators had never been charged with illegal gun possession, while 13% had never been charged with a serious offense. In contrast, the tool designed by Chattopadhyay and his colleagues uses hundreds of thousands of sociological patterns to figure out the risk of crime at a particular time and space.

The study, Event-level Prediction of Urban Crime Reveals Signature of Enforcement Bias in U.S. Cities, was supported by the Defense Advanced Research Projects Agency and the Neubauer Collegium for Culture and Society.

___

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Algorithm claims to predict crime in U.S. cities before it happens - SecurityInfoWatch

UST Strengthens Presence in the Health Tech Sector with Strategic Investment in Israeli SaaS Start-up Well-Beat – PR Newswire

Innovative new digital patient engagement solution allows for dynamic personalization and improved outcomes

TEL AVIV, Israel and ALISO VIEJO, Calif., July 6, 2022 /PRNewswire/ --UST,a leading digital transformation solutions company has announced that it will strengthen its presence in the healthcare technology market with a strategic investment inWell-Beat, a pioneering Israeli start-up that adds a human touch to healthcare through patient-centered behavioral AI. The investment in Well-Beat is the latest example of UST accelerating the adoption of emerging tech solutions in healthcare and transforming lives through the power of technology.

By investing in Well-Beat, UST is helping to bring one of the success stories of the innovative Israel start-up tech ecosystem to a wider global market. Combining the size and scale of UST with the agility of Well-Beat, this strategic investment will put digital transformation to work for patients at a time when healthcare delivery systems are strained and intelligent patient engagement is increasingly critical.

"At UST, we work with academia, innovators and entrepreneurs from across the global start-up community to bring the very best transformational solutions to market. However, we only directly invest in less than one percent of our partnerships those that represent the best of the best in emerging health tech. Well-Beat has earned its reputation as a successful innovator in the rapidly evolving HealthTech space, and we're thrilled to offer a platform which empowers them to continue their groundbreaking work," said Sunil Kanchi, Chief Information Officer & Chief Investment Officer, UST.

UST, together with Well-Beat, created a first-of-its-kind digital patient engagement Software as a Service (SaaS) solution that dynamically adapts to each individual patient over time, delivers personalized conversational guidelines to the clinician at the point of care, offers customized prompts that are shaped by the profile of each individual patient and helps deliver direct and indirect behaviorally guided motivational nudges to patients based on over 1,400 unique factors.

Utilizing information gathered through medical records, connected devices and short patient surveys, Well-Beat's technology dynamically adapts patient communication to provide intelligent interventions and highly customized experiences. Furthermore, this latest patient engagement solution designed in collaboration with UST is able to seamlessly operate within the existing health tech ecosystem of any healthcare delivery organization. This includes working with electronic health record (EHR) systems, public cloud providers, patient registries and existing wellness or care management applications.

Capable of operating without mandating changes to existing workflows or onboarding to a new platform, this dynamically personalized digital patient engagement solution is designed to help healthcare organizations achieve greater returns on their existing IT investments as well as achieve higher response rates and better engagement through their existing communication channels.

"As healthcare transitions outside the four walls of the hospital, the behavioral AI powered patient engagement solution that UST has built with Well-Beat enables healthcare organizations to effectively engage high-risk patients - resulting in improved care outcomes," saidRaj Gorla, Chief Executive Officer, UST ContineoHealth.

"Well-Beat is excited about strengthening our relationship with UST. The increased collaboration and ability to leverage UST's vast experience and resources will help us continue to deliver personalized patient outreach," saidRavit Ram Bar-Dea, Co-Founder & Chief Executive Officer, Well-Beat. "We feel that UST's leadership and expertise across the entire healthcare technology ecosystem and continuum is tailor-made to complement our strengths as we look to bring new products to market."

About UST:

For more than 22 years, UST has worked side by side with the world's best companies to make a real impact through transformation. Powered by technology, inspired by people, and led by our purpose, we partner with our clients from design to operation. Through our nimble approach, we identify their core challenges, and craft disruptive solutions that bring their vision to life. With deep domain expertise and a future-proof philosophy, we embed innovation and agility into our clients' organizationsdelivering measurable value and lasting change across industries, and around the world. Together, with over 30,000 employees in 30+ countries, we build for boundless impacttouching billions of lives in the process. Visit us atwww.UST.com

About Well-Beat:

Well-Beat providesa next-generation patient behavioral change solution, based on human behavior, expert understanding and proprietary data-driven technology. At its core, the solution empowers healthcare providers and organizations to dramatically increase patient engagement and treatment regime adherence.

The company's mission is to bring humanity to healthcare through raising the level of engagement and personal responsibility of patients to their health and wellness regime. By incorporating Well-Beat insights into their daily practices, healthcare providers can generate more effective face-to-face meetings with patients, along with digital intelligent interventions, to ultimately provide the most suitable wellness program and approach for each patient. Through adjustment of personalized interactions to every patient, Well-Beat enables healthcare organizations to boost their operational efficiency, increase revenues and reduce long-term healthcare costs, while maintaining the level of treatment. Learn more athttps://www.well-beat.com/

Media Contacts, UST:

Tinu Cherian Abraham+1 (949) 415-9857

Merrick Laravea+1 (949) 416-6212

Neha Misri+91-9972631264[emailprotected]

Media Contacts, U.S.:

S&C PR+1-646.941.9139[emailprotected]

Media Contacts, Australia:

Team Lewis[emailprotected]

Media Contacts, U.K.:

FTI Consulting[emailprotected]

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SOURCE UST

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UST Strengthens Presence in the Health Tech Sector with Strategic Investment in Israeli SaaS Start-up Well-Beat - PR Newswire

Top Virus Expert Warns Boosted People to Do This "As Soon as" They Can – Best Life

If you've felt like COVID's stronghold on the U.S. has loosened over the last few months, you're hardly alone. In fact, most Americans now say that their lives are looking more and more like they did pre-pandemic. According to a poll from the Associated Press-NORC Center for Public Affairs Research and the SCAN Foundation, 54 percent of adults feel their lives are somewhat the same as before and 12 percent feel that their lives are exactly the same today as they were before the pandemic hit. COVID cases are falling at the moment, with the Centers for Disease Control and Prevention (CDC) reporting a more than 5 percent decrease in new daily infections this week compared to last.

READ THIS NEXT: Dr. Fauci Just Said Virus Experts Are "Very Concerned" About This.

But the coronavirus is far from eradicated. Many virus experts have warned about a potential surge later this year, as the fall and winter seasons have already proved to be the most dangerous times for COVID's spread. Thomas Campbell, MD, an internal medicine physician who ran clinical trials for COVID vaccines, told UCHealth in Aurora, Colorado, that it's "important to plan for another wave in the fall and winter because there's a good probability that it will happen," as COVID will likely continue to spread due to a variety of factors.

"Both vaccine-induced immunity and immunity from natural infection wane over time. We have a virus that's still here along with waning immunity. And human behavior changes in the fall," Campbell explained. "Kids will go back to school. The weather will be colder. The daylight hours will be shorter, so people will be indoors more and having more contact with other people. Then, we'll have Thanksgiving, Christmas, and New Year's, and travel associated with the holidays We have all the ingredients necessary to create a new wave."

The continued emergence of new Omicron subvariants is also likely to aid a future COVID surge, which is why vaccine manufacturers like Pfizer and Moderna have started to "create new, tailored versions of their booster shots that will better combat Omicron variants," according to UCHealth. On June 30, an advisory committee for the U.S. Food and Drug Administration (FDA) recommended approval for these new Omicron-specific booster vaccine formulas.

"The original vaccines and boosters did not specifically fight these Omicron variants because they hadn't developed yet," UCHealth further explained. "The vaccine makers have pledged to deliver the new doses by fall."

RELATED:For more up-to-date information, sign up for ourdaily newsletter.

But the likelihood of new booster shots has some people questioning when they should be getting their additional doses. Everyone over the age of 5 is eligible for a singular booster shot at least five months after their primary vaccine series, according to the CDC.A second booster is also available to adults who are 50 and older, as well as those 12 and older who are moderately or severely immunocompromised, once it has been at least four months since they received their first boost.

The CDC reports that nearly half of those fully vaccinated have gotten their first booster shot so far, but vaccination rates for the second booster are much lower. This may be partly because some people are unsure if they should be waiting for this additional dose, whether to better time it with the expected fall COVID surge or to get the new Omicron-specific booster formula. If you're holding out for one of these reasons, virus experts have a clear warning: Don't wait to get the second booster.ae0fcc31ae342fd3a1346ebb1f342fcb

"There is a high level of community transmission right now, so it's better to get it as soon as you are eligible to allow time to build up antibodies," Hannah Newman, MPH, the director of infection prevention at Lenox Hill Hospital in New York City, told WebMD. According toAmesh Adalja, MD, an assistant professor at the Bloomberg School of Public Health at Johns Hopkins University, it takes "probably seven days or so until you reach the peak protection for the immune system to have reacted."

Campbell also advised against waiting for a second booster, urging boosted individuals to get it as soon as possible as new variants continue to spread and vaccine-based immunity wanes further. "With the Omicron variant, after the first booster dose, the protection starts to really drop off by about six months," he said.

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Top Virus Expert Warns Boosted People to Do This "As Soon as" They Can - Best Life