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Biochemistry

Important enzyme for the composition of the gut microbiome discovered – Phys.org

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The intestinal microbiome, i.e., the community of bacteria and other microorganisms that live in the human gut, has been shown to affect the metabolism and the immune system. We still do not fully understand how the symbiosis between a healthy microbiome and the host is regulated and how bacterial overgrowth with pathogenic germs can be prevented.

A research team led by Professor Christoph Becker-Pauly from the Institute of Biochemistry at Kiel University (CAU) in collaboration with other working groups has now discovered an important mechanism influencing the intestinal microbiome in mouse models. The results were recently published in the journal Science Advances.

"For the first time, we were able to show that a complex of the enzymes meprin and meprin located on intestinal cells influences the microbiome composition by processing the substrate galectin-3," explained first author Cynthia Blck, Ph.D. student at the CAU's Institute of Biochemistry.

"The activity of this enzyme complex is in turn directly influenced by the microbiome," added Professor Christoph Becker-Pauly, member of the Cluster of Excellence "Precision Medicine in Chronic Inflammation" (PMI) and head of the Unit for Degradomics of the Protease Web. "This means that the microbiome influences host proteins, which in turn influence the microbiome."

The researchers studied this interplay of regulation of the enzyme complex in mouse models with different bacterial colonizations.

The research focused on the protein-cleaving enzymes meprin and meprin , which are strongly expressed in healthy intestine and are significantly downregulated in chronic inflammatory bowel disease (IBD). "On the one hand, we wanted to elucidate the function of meprins in the small and large intestine, and on the other hand, we wanted to understand how the composition of bacteria in the intestine is fundamentally regulated," said Blck.

Meprin proteases are found throughout the entire intestine, but they are not typical digestive enzymes. "In previous studies, we were already able to show that these enzymes are responsible for constant detachment and renewing of the mucus layer that protects the small intestinal epithelium," said Becker-Pauly.

In order to clarify the further functions of meprins, which exist as the meprin / complex in the large intestine, the researchers first employed a mass spectrometry-based method to search for substrates that are processed by this enzyme complex. "We identified galectin-3 as an important substrate in the large intestine," stated Becker-Pauly.

Galectin-3 is permanently produced in the intestinal villi. It is found both within the cells but also outside the cell in the mucus layer and can interact with bacteria, for example by agglutination. Proteolytic cleavage of galectin-3 by meprin / resulted in altered bacterial binding properties. At the same time, depending on the bacterial composition, enzymatic processing of galectin-3 changes. "This means that depending on how many and which bacteria are present, it also has an influence on how much galectin-3 is enzymatically processed," explained Blck. "The host responds to the microbiome via the cleavage of galectin-3, which is then modulated differently."

The work also showed that the enzymatic cleavage of galectin-3 leads to strong agglutination (clumping) and elimination of the pathogen Pseudomonas aeruginosa, a germ that is responsible for about 10% of all hospital infections in Germany.

"Understanding the physiological role of this enzyme complex in the intestine could provide new insights into the development of diseases as well as new ways to prevent and treat intestinal diseases," emphasized Becker-Pauly. In chronic inflammatory bowel diseases, not only the enzyme complex is reduced, but also the substrate galectin-3 is also downregulated. "This may lead to an imbalance of the the intestinal microbiome so that pathogens can spread more easily," suspects the Kiel biochemist. This constellation is certainly not decisive for the development of chronic inflammatory bowel diseases, as many factors play a role in this regard, but it should be considered.

Further research will now focus on elucidating the mechanisms in more detail that lead to the agglutination of certain types of bacteria. In addition, further immunomodulatory substrates of the meprin / complex have been identified and their function will now be analyzed.

More information: Cynthia Blck et al, Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis, Science Advances (2023). DOI: 10.1126/sciadv.adf4055

Journal information: Science Advances

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Important enzyme for the composition of the gut microbiome discovered - Phys.org

Biochemistry

Man linked to firebombing of Wisconsin anti-abortion group via leftover burrito – Yahoo News

[Source]

A half-eaten burrito led to the arrest of a man believed to be responsible for firebombing the office of an anti-abortion group in Madison, Wisconsin, authorities announced last week.

Hridindu Sankar Roychowdhury, 29, was charged with one count of attempting to cause damage by means of fire or an explosive for the incident, which took place at Wisconsin Family Actions headquarters last Mothers Day, May 8, 2022.

Police responded at around 6 a.m. to a fire that broke out at the Madison-based building. Inside, they found suspicious items, including a disposable lighter and two mason jars one broken and another containing a clear fluid that smelled like an accelerant.

Meanwhile, the outside of the building was spray-painted with If abortions arent safe then you arent either. Another wall was painted with a large encircled A and 1312.

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Last month, police identified Roychowdhury as a possible suspect and matched his DNA from a leftover burrito he had thrown in a public trash can to the crime scene.

Roychowdhury, who lives in Madison, was arrested in Boston last Tuesday. If convicted, he faces between five to 20 years in prison.

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Violence is never an acceptable way for anyone to express their views or their disagreement, Robert R. Wells, assistant director of the FBIs Counterterrorism Division, said in a statement. Todays arrest demonstrates the FBIs commitment to vigorously pursue those responsible for this dangerous attack and others across the country, and to hold them accountable for their criminal actions.

Wisconsin Family Action, who blamed the attack on a leftist anarchist group, is a nonprofit that defends Gods plan for marriage, family, life and religious freedom.

No one was in the office at the time of the attack.

Story continues

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The incident came about a week after a draft opinion suggesting that the Supreme Court would overturn Roe v. Wade had leaked. The court officially made that call in June, bringing back Wisconsins abortion ban.

Twitter account Antifa Watch has shared social media posts allegedly made by Roychowdhury. In them, he identified himself as a graduate research assistant at the University of Wisconsin-Madison (UW-Madison) and made statements such as Im an anarchist now and I hope to see this country burn.

UW-Madisons May 2022 commencement announcement reportedly listed Roychowdhurdy as a doctoral candidate. A UW-Madison spokesperson confirmed that he received a doctorate in biochemistry but that he is no longer attached to the institution.

The individual that you reference received a PhD in biochemistry from UW-Madison in May 2022. He is no longer affiliated with the university, the spokesperson told Fox News.

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Man linked to firebombing of Wisconsin anti-abortion group via leftover burrito - Yahoo News

Biochemistry

NSCBMC Recruitment 2023: Check Posts, Qualification and How to … – StudyCafe

NSCBMC Recruitment 2023: Check Posts, Qualification and How to Apply

NSCBMC Recruitment 2023: Netaji Subhash Chandra Bose Medical College (NSCBMC) is inviting applications from eligible candidates for the posts of Research Scientist-II, Research Scientist-I, Lab Technician, Lab Assistant Cum Data Entry Operation (Grade-A) and Project Technician (IPEM Filed Worker) on a temporary and co-terminable with the project. As mentioned in the official notification of NSCBMC recruitment 2023, there are a total of 06 vacancies for the given posts. According to the official notification of NSCBMC recruitment 2023, the upper age limit is different for every post as given below in the article. As given in the official notification of NSCBMC recruitment 2023, the selected candidates will be given a monthly salary of upto Rs. 67000.

In accordance with the official notification of NSCBMC recruitment 2023, interested and eligible candidates can appear for the interview along with a duly filled-in application forms and relevant documents. The walk-in interview will be held on 11.04.23 at the Office of the Dean, NSCB, Medical College, Nagpur Road, Jabalpur (M.P) between 11 am to 1 pm.

NSCBMC is looking for qualified candidates for the posts of Research Scientist-II, Research Scientist-I, Lab Technician, Lab Assistant Cum Data Entry Operation (Grade-A) and Project Technician (IPEM Filed Worker) on a temporary and co-terminable with the project. As mentioned in the official notification of NSCBMC recruitment 2023, there are a total of 06 vacancies for the given posts.

According to the official notification of NSCBMC recruitment 2023, the upper age limit is given below.

For Research Scientist II- The upper age limit is 40 years.

For Research Scientist-I- The upper age limit is 35 years.

For Lab Technician- The upper age limit is 30 years.

For Lab Assistant Cum Data Entry Operation (Grade-A)- The upper age limit is 30 years.

For Project Technician (IPEM Filed Worker)- The upper age limit is 30 years.

Note 5 years age relaxation in case of ST/SC category candidates.

Candidates applying for NSCBMC recruitment 2023, must have the given below qualification.

For Research Scientist-II-

1- Postgraduate degree (MD/DNB) in Pathology/Biochemistry/Microbiology subject from a recognized university with 5 years R&D experience in Pathology Genetics or biomedical subjects OR MBBS Degree recognized by MCI from a recognized university with a minimum of 10 years R&D experience in Genetics or biomedical subjects OR Ph.D. degree in life sciences/ Biochemistry/ Microbiology/ Biotechnology in the relevant subject or equivalent from a recognized University with 5 years R&D experience in the related subject after Ph.D. OR First class Masters Degree in Biochemistry/ Microbiology/ Biotechnology /equivalent degree from a recognized University with 8 years R&D experience in Genetics or the biomedical subjects in recognized institute(s)

2- Thorough knowledge of Medical Statistics, Computer Applications/Data Management, data analysis and interpretation of results of statistical analysis

Desirable-Experience on Molecular biology techniques, immunohistochemistry and tumor pathology including histopathology and cytopathology. 2. Not less than 3 research publications (accepted) in indexed scientific journals 3. Supervised/ investigated scientific research projects as PI/ C-PI/ Co-L

For Lab Technician-

1- First class M.Sc. degree in life sciences / Biochemistry/ Microbiology! Biotechnology or related subject or equivalent degree from a recognized University with a minimum of 1 year of working experience in a clinical/ research laboratory and working knowledge of molecular biology equipment

2- Knowledge of Computer applications.

For Lab Assistant Cum Data Entry Operation (Grade-A)-

B.Sc degree from a recognized university with 1 years relevant experience as a Laboratory Assistant cum Data Entry Operator in clinical/research laboratory in a reputed institution.

Desirable-

1- Postgraduate Diploma in computer application.

2- Data evaluation experience.

To read the qualifications of all posts check the official notification

In accordance with the official notification of NSCBMC recruitment 2023, candidates will be given a monthly salary as given below-

For Research Scientist-II- The selected candidate will be given a monthly salary of Rs. 67000.

For Research Scientist-I- The selected candidate will be given a monthly salary of Rs. 56000.

For Lab Technician, Lab Assistant Cum Data Entry Operation (Grade-A) and Project Technician (IPEM Filed Worker)- The selected candidate will be given a monthly salary of Rs. 20000.

As per the official notification of NSCBMC recruitment 2023 notification, eligible candidates can appear for the interview along with duly filled-in application forms and relevant documents on 11.04.23 at the Office of the Dean, NSCB, Medical College, Nagpur Road, Jabalpur (M.P) between 11 am to 1 pm.

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NSCBMC Recruitment 2023: Check Posts, Qualification and How to ... - StudyCafe

Biochemistry

Celebrating undergrad thesis research at Barrett, The Honors … – ASU News Now

April 5, 2023

Chloe Leff, a junior in Barrett, The Honors College at Arizona State University, has been awarded the Goldwater Scholarship, the most prestigious award in the United States for undergraduate researchers in the natural sciences, engineering and mathematics, or STEM.

The Goldwater Scholarship was established in 1986 by Congress to serve as a living memorial to honor the lifetime work of Arizona Sen. Barry Goldwater. The scholarship helps ensure that the U.S. continues to produce the worlds leading scientists and engineers. Chloe Leff, an ASU junior pursuing dual bachelor degrees in biochemistry and molecular bioscience and biotechnology, has been awarded the Goldwater Scholarship, the most prestigious award in the United States for undergraduate researchers in the natural sciences, engineering and mathematics. Download Full Image

If you are an undergrad in STEM, the Goldwater Scholarship is the big prize, said Kyle Mox, associate deanat theLorraine W. Frank Office of National Scholarships Advisementand the designated campus representative for the Goldwater Scholarship. In addition to a $7,500 stipend, winning a Goldwater carries immense prestige and positions you for admission to top-tier PhD programs and other major fellowships, like the Rhodes Scholarship, Churchill Scholarship or NSF Graduate Research Fellowship.

Of the 2022 ASU Goldwater cohort, two seniors, Claire Blaske and Jasmin Falconer, were recently selected for the NSF program, and senior Katie Pascavis was selected as a Marshall Scholar.

Receiving the Goldwater Scholarship is a huge honor, not just for the recognition of what I have achieved as an undergraduate, but for the vote of confidence in my abilities to succeed in research, Leff said. I want to pursue a career in research, so receiving the Goldwater Scholarship is an added boost of confidence and testament to my capability as a researcher.

Leff, an Arizona native and graduate of Hamilton High School, is pursuing dual bachelor degrees in biochemistry and molecular bioscience and biotechnology. After graduation, she plans to pursue a PhD in immunology and conduct medical research pertaining to disease treatments, particularly cancer.

Since 2021, she has been a member of the Hariadi Lab in the Biodesign Institute, where she assists with research on the use of DNA nanostructures to decrease the infectivity of viruses. In the summer of 2022, as a participant in the DAAD-RISE program, she worked at Justus-Liebig University in Gieen, Germany, contributing to a project that investigates the impact and mechanism behind two synergistic cancer drugs.

Outside of her research work, she serves as the director of events for the Barrett Sustainability Club, is the president of the Gammage Scholars and plays for the ASU womens club soccer team.

Although the national submission deadline for the Goldwater Scholarship occurs annually at the end of January, the ASU scholarship office begins the recruitment and advising process in October.

Each college or university may nominate only four students per year to the Goldwater Scholarship, so the scholarship office establishes a preliminary deadline in early December.

In reality, the most difficult part of the process is receiving a nomination, Mox said. We have so many talented, motivated STEM majors at ASU, and there are ample opportunities to get significant undergraduate research here.

The applications are then reviewed by members of a long-standing faculty nominating committee, who evaluate the candidates academic records, research achievements and letters of recommendation.

I am so grateful to have been one of ASU's nominees, Leff said. Having worked in undergraduate research at ASU for nearly two years, it is an honor to be recognized as a high-achieving student by my university and community of scientists. ASU gave me my first opportunities in undergraduate research, so it is a privilege to be able to represent the university in a national competition centered around excellence in STEM.

The planning, drafting and revision process can be arduous. The Goldwater application requires multiple short essay responses and a three-page research proposal, in which applicants summarize their previous research and describe their future research goals. Throughout the process, applicants seek advice and guidance from the scholship office and their faculty members.

I found that the application process was a great opportunity to reflect on the reasons why I am so drawn to science and research, Leff said. For as long as I can remember, a career in some sort of science was in my future, but having to clearly articulate that passion and clarify how it has transformed into a desire to pursue research specifically encouraged me to recognize how that path reflected my values.

Over the past decade, 21 Sun Devils have been awarded the Goldwater Scholarship, ranking ASU alongside Duke and Princeton and ahead of Northwestern and UC-Berkeley. In the 2023 application cycle, 413 Goldwater Scholarships were awarded from a national pool of over 5,000 applicants. More than 400 colleges and universities submitted nominees.

Story submitted by the Lorraine W. Frank Office of National Scholarships Advisement

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Celebrating undergrad thesis research at Barrett, The Honors ... - ASU News Now

Biochemistry

Unraveling the protein map of cell’s powerhouse – ASBMB Today

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes. Researchers at the University Hospital Bonnand the University of Freiburg have gained systematic insight into the organization of proteins in mitochondria. The protein map of mitochondria represents an important basis for further functional characterization of the powerhouse of cell and thus provide implications for diseases. The study has now been published in the renowned scientific journal Nature.

Mitochondria are among the most important cell compartments. They are delimited organelles surrounded by a double membrane. Mitochondria are considered the powerhouse of the cell, as they produce the majority of the energy required for all cellular processes. In addition, they take over many other functions in metabolism and provide a signaling surface for inflammatory processes and programmed cell death. Defects in mitochondria lead to numerous diseases, especially of the nervous system.

Model of the quality control mechanism for removing arrested proteins from the mitochondrial entry gate.

Therefore, the molecular understanding of mitochondrial processes is of highest relevance for basic medical research. The molecular workers in the cell are usually proteins. Mitochondria can contain around 1,000 or more different proteins. To execute functions, several of these molecules often work together and form a protein machine, also called a protein complex. Proteins also interact in the execution and regulation of molecular processes. Yet little is known about the organization of mitochondrial proteins in such complexes.

The research groups of Thomas Becker and Fabian den Brave at the UKB, together with the research groups of Bernd Fakler, Uwe Schulte and Nikolaus Pfanner at the University of Freiburg, have created a high-resolution image of the organization of proteins in protein complexes, known as MitCOM. This involved a specific method known as complexome profiling to record the fingerprints of individual proteins at an unprecedented resolution. MitCOM reveals the organization into protein complexes of more than 90% of the mitochondrial proteins from bakers yeast. This allows to identify new proteinprotein interactions and protein complexes an important information for further studies.

Researchers at UKB in cooperation with Collaborative Research Center 1218 (Regulation of cellular function by mitochondria)have shown how this dataset can be used to elucidate new processes. Mitochondria import 99% of their proteins from the liquid portion of the cell, known as cytosol. In this process, a protein machinery called the TOM complex enables the uptake of these proteins through the membrane into the mitochondria. However, it is largely unclear how proteins are removed from the TOM complex when they get stuck during the transport process. To elucidate this, the team led by Becker and den Brave used information from the MitCOM dataset. It was shown that non-imported proteins are specifically tagged for cellular degradation. Research by the Ph.D. student Arushi Gupta further revealed a pathway by which these tagged proteins are subsequently targeted for degradation. Understanding these processes is important because defects in protein import can lead to cellular damage and neurological diseases.

The example from our study demonstrates the great potential of the MitCOM dataset to elucidate new mechanisms and pathways. Thus, this map of proteins represents an important source of information for further studies that will help us to understand the functions and origin of the cells powerhouse, saidBecker, director of the Institute of Biochemistry and Molecular Biology at UKB.

This article was first published by University Hospital Bonn. Read the original.

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Unraveling the protein map of cell's powerhouse - ASBMB Today

Cardiology

Heart Health is What Keeps This Penn Cardiology Patient Running – Penn Medicine

After finishing his first triathlon, Sanjay Shah celebrated fairly typically by hugging his wife and daughters. He then stepped aside to make a phone call. It was to his cardiologist.

Im alive and I finished the race, Shah told his doctor at the Perelman School of Medicine at the University of Pennsylvania.

Shah was back into racing condition thanks, in part, to guidance and care from sports cardiology professionals at Penn Medicine.

His training started years before with a decision to take charge of his health in a broader way. Earlier in life, he faced a diabetes diagnosis. That later led to Shah becoming more active. He even lost 40 pounds while training for marathons. He then entered the Rock and Roll Half Marathon in 2009.

That race, and Shahs spirit, came to a sudden stop during mile ten of the half marathon.

I had started feeling a tingling in my jaw. I had taken a caffeine gel during the race, and thought maybe that was affecting me somehow. It was more than just a tingling jaw. Shahs friends noticed a change in his color and urged him to stop running. They wanted to call 9-1-1, but Shah insisted he just needed to rest for a minute or two. Then, he started running again, finishing the final three miles of the race. Despite the accomplishment, instead of words of congratulations, his friends had a blunt and clear message for him, They made me promise that I would go to a cardiologist, recalls Shah.

Days later Shah was sitting in a Penn cardiologists office to undergo stress tests. Twelve minutes on the treadmill didnt raise any red flags. After all, Shah was an avid runner. However, more stress tests that day would, indeed, reveal he was having heart issues.

Shah had trouble wrapping his head around this new reality. "I felt pretty depressed just knowing I had a heart issue. I took pride in exercising regularly. I was even training other people for marathons, Shah recalls. His doctors had said with proper recovery time and a healthy diet, he could take up racing once again.

Racing was the least of his worries at the time, however. This sudden health complication left Shah worrying what the future held for family. "I had no will. I had two girls that I needed to put through college, says Shah. As men we dont like to cry, but I came close to it."

Doctors recommended an angioplasty and four stents to clear blockages in multiple arteries.

Before the procedure even took place, Shah decided hed give himself a challenge that hed never attempted: completing that triathlon.

I signed up to do Philadelphia Triathlon before my angioplasty. I told my doctor look, I have so much faith that I signed up to do a triathlon. I will cross that finish line."

Shahs surgery was a success, but he knew that simply completing the surgery and receiving stents wasnt a green light to completing a triathlon. This became alarmingly clear to him when he started having some mild chest pains during training. Shah knew he needed guidance so that he didnt inadvertently create more health problems for himself. Thats when he turned to Neel P. Chokshi, MD, MBA, medical director of the Sports Cardiology and Fitness Program and an associate professor of Cardiology in the Perelman School of Medicine at the University of Pennsylvania. He asked Chokshi about that minor chest pain, and more. He was also interested understanding effective training protocols for a triathlon to optimize his performance, minimize his risk of a heart related event and improve his diabetes via exercise, recalls Chokshi.

While Shah still struggled to wrap his mind around how someone as active as him could have such serious heart issues, Chokshi says although coronary disease in avid exercisers may seem unlikely, its not uncommon to find other risk factors that can raise risk for heart issues. Diet, cholesterol, blood pressure and lifetime exposure to these factors are important contributors to risk. What is often more surprising in these patients, is the presentation or signs of disease. These patients often present with subtler symptoms in light of their high degrees of fitness. Chokshi says even a small change in running pace or mild chest pains during a warm up can often represent a real issue.

Shah underwent several tailored stress tests with Chokshi and his team to ensure his safety at a high intensity of exercise, but a triathlon is difficult to simulate in a doctors office. Additional stressors, according to Chokshi, include heat stress and electrolyte changes from hours of endurance activity, as well as the possibility of heart attacks or irregular heart rhythms triggered by similar competitive situations.

We encouraged him to log more training hours and to participate in shorter events to build up to a triathlon race, says Chokshi. From there, Shah worked with one of Penns exercise physiologists to develop a training program.

Since his first successful triathlon, Shah has completed a total of six Half Ironman races up and down the East Coast. He credits is care team at Penn Medicine for giving him a second chance at life. When his heart issues were discovered back in 2009, Shah chose to view the complications as a way to change course for the better.

I had two options, Shah recalls. I can look at this and be sad and stop doing what Im doing, or I can pick up another challenge and catch the bull from the horns.

Chokshi says that kind of attitude in a heart patient is key to success, Completing a triathlon is a significant feat for any individual given the mental toughness, physical endurance and commitment required. Patients are often discouraged by their conditions and even their age, but Sanjays story demonstrates the possibilities after being diagnosed with a heart issue.

Running has now become a family affair for the Shahs. Sanjays granddaughters, ages 6 and 8, are now taking part in 5ks with their grandfather. Shahs own daughter is now a coach for a girls track team. Shah is eager to share his story with family, friends, and anyone who will listen to spread the message about heart health. He says exercise and a healthy diet are crucial.

"Having fun and enjoying life is in important. But you dont want to pay for it and you lose it all. It's not worth losing it all due to the bad effects it has on your heart. We all like to party, drink, eat what we wantbut we pay the price."

To learn more about Penns Sports Cardiology and Fitness program, or to find a doctor, click here.

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Heart Health is What Keeps This Penn Cardiology Patient Running - Penn Medicine

Cardiology

PeaceHealth 1st in Oregon to earn American College of Cardiology … – Becker’s ASC Review

Springfield, Ore.-based PeaceHealth Sacred Heart Medical Center at RiverBend has become the first hospital in the state to receive the American College of Cardiology's Certified Transcather Valve Center designation.

The certification honors the facility for meeting the highest standards as determined by the ACC for transcatheter aortic valve replacement (TAVR) and Mitraclip procedures, according to an April 6 news release.

TAVR and Mitraclip procedures are less invasive alternatives to open heart repair or replacement.

The first TAVR was performed at the PeaceHealth facility in 2012, and since then, surgeons have performed more than 1,200.

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PeaceHealth 1st in Oregon to earn American College of Cardiology ... - Becker's ASC Review

Cardiology

PVM Cardiologist Anna McManamey Participates in Tuskegee … – Purdue University

Friday, April 7, 2023

For nearly 60 years, the Tuskegee University College of Veterinary Medicine has hosted its annual Veterinary Medical Symposium and this year a Purdue Veterinary Medicine clinician served as a featured speaker.Dr. Anna McManamey, clinical assistant professor of cardiology, gave the Lunch and Learn presentation Friday, March 24, on the topic, Diagnostic and Treatment Strategies for Asymptomatic Heart Disease. The talk was sponsored by Boehringer Ingelheim Animal Health.Board certified in cardiology by the American College of Veterinary Internal Medicine, Dr. McManamey is a 2016 DVM graduate of the University of Missouri College of Veterinary Medicine and completed her residency at North Carolina State University.She joined the Purdue faculty in 2021.

The 57th Annual Tuskegee Veterinary Medical Symposium, which was held March 22-25, focused on the theme Cultivating a Sustainable Future for the Veterinary Profession. This year marked the first time since the pandemic that the event was held in person. This conference brings together veterinarians and Tuskegee alumni from across the country to discuss important issues related to animal health and veterinary medicine.The event also honored Tuskegee University College of Veterinary Medicine reunion classes, including PVM Dean Willie Reeds class, the Class of 1978, which celebrated its 45th reunion.

The Tuskegee University College of Veterinary Medicine is the only veterinary medical professional program located on the campus of a historically black college or university (HBCU) in the United States. The first class graduated in 1945.Today, the total number of Tuskegee veterinary medical graduates is nearly 3,000.

Writer(s): Kevin Doerr | pvmnews@purdue.edu

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PVM Cardiologist Anna McManamey Participates in Tuskegee ... - Purdue University

Cardiology

Cardiology suicide report: 6 things to know – Becker’s ASC Review

While 1 percent of cardiologists have attempted suicide, an additional 8 percent have thought about attempting suicide, according to Medscape's 2023 "Cardiologist Suicide Report," which looked at survey results from over 9,100 practicing physicians across 29 specialties.

Here are five additional things to know from the report:

1. Two percent of female cardiologists have attempted suicide, compared to less than 1 percent of male cardiologists.

2. While 12 percent of female cardiologists have considered suicide, that number drops to 7 percent among male cardiologists.

3. Cardiologists between ages 42 and 56 are the most likely to have suicidal ideations, at 12 percent. An additional 2 percent have attempted suicide.

4. While 40 percent of respondents reported telling a family member about suicidal ideations, 5 percent reported calling a suicide hotline.

5. About 18 percent of cardiologists believe that health systems and medical schools should be responsible for student and physician suicide, and 55 percent believe they should not be.

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Cardiology suicide report: 6 things to know - Becker's ASC Review