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Anatomy

It Still Stings: Grey’s Anatomy Gave Alex Karev a Fate Worse Than … – Paste Magazine

Editors Note: TV moves on, but we havent. In our feature series It Still Stings, we relive emotional TV moments that we just cant get over. You know the ones, where months, years, or even decades later, it still provokes a reaction? Were here for you. We rant because we love. Or, once loved. And obviously, when discussing finales in particular, there will be spoilers:

Few shows stay on the air long enough to outlast their entire first spinoff series, earn a second spinoff series, and then ultimately soft-reboot the original series itself by transplanting in a new young cast into the same spots where the old guard once stoodbut of course, few shows are Greys Anatomy. Created by Shonda Rhimes in 2005, the medical drama is now on its nineteenth season and just survived the departure of its titular character, Meredith Grey (Ellen Pompeo), without missing a beat. In fact, before Meredith made her (weirdly anticlimactic) exit, the series shifted its focus to a new crop of interns, several of whom bear remarkable similarities to Meredith and her original class of five.

Taking Merediths place as the legacy hire is Dr. Lucas Adams (Niko Terho), the nephew of rockstar neurosurgeons Derek (Patrick Dempsey) and Amelia Shepherd (Caterina Scorsone). Filling Cristina Yangs (Sandra Oh) place as the brilliant and ambitious no-nonsense overachiever is Dr. Benson Kwan (Harry Shum Jr.). Dr. Jules Millin (Adelaide Kane) comes from a working-class background just like Izzie Stevens (Katherine Heigl). And while neither Dr. Simone Griffith (Alexis Floyd) or Dr. Mika Yasuda (Midori Francis) are precise analogues for George OMalley (T.R. Knight) or Alex Karev (Justin Chambers), there are definite echoes of the original cast members spread throughout the group.

I just wish those echoes didnt make me so cranky. Because by reminding me of the halcyon days of Meredith, Cristina, George, Izzie, and Alex, Im also forced to recall just how awful Alexs exit was.

As far as terrible Greys Anatomy send-off storylines go, it would take a lot to top the final episode of George OMalley, who was hit by a bus and rendered unrecognizable for most of his swan song, until he finally managed to communicate his identity to Meredith right before dying in surgery. But Georges exit was arguably preferable to that of Alex Karev, whose bizarre reasons for his abrupt departure bore even less resemblance to his character than John Does mutilated face did to George.

Of course, the reason behind Alexs sudden exit is because series original cast member Justin Chambers decided to leave Greys Anatomy for personal reasons in the middle of its 16th season. I dont know the reasons behind Chambers decision and dont want to speculate, since its none of my business. I hope he felt (and still feels) good about his departure, and I wish him well.

I acknowledge that the unplanned departure of a character who had nearly reached the pinnacle of his series-long trajectory undoubtedly threw the Greys Anatomy writers for a major loop. Alex was clearly being set up for success: being hired as Chief of Staff and Chief of Surgery for Grey Sloan Memorials rival Pacific Northwest General Hospital, blissfully happy with his wife Jo (Camilla Luddington), best friend and right-hand-Person to Meredith Grey, and almost definitely poised to soon become a father. Whats more, at the time of his departure, Chambers was one of only four remaining original cast members, along with Pompeo, James Pickens Jr., and Chandra Wilson. How does one simply write off a character that has been so integral to the fabric of the series for a decade and a half, especially with no notice and without the actor even available to film his final episode?

Not. Like. This.

Before we get into what Alex didor rather, what was done to Alex, since I still refuse to believe Alex himself would have willingly done any of thislets go back and quickly recap his impressive journey since we first met him in the pilot episode.

Alex Karev was introduced as a cocky, misogynist jerk known mostly for giving nurses STDs, objectifying and condescending to his fellow interns, and freezing up during surgery. He was, to put it mildly, The Worst, and remained that way for much of Greys Anatomys early days.

Eventually, though, he started to grow up. He fell in love with fellow intern Izzie Stevens, and even when she broke things off with him, she carried a soft spot for him. He developed a surprising aptitude for pediatrics, and an even more surprising gentle rapport with his young patients. And as he was continually challenged professionally and emotionally, he found that he was capable of rising to those challenges. Over time, healthy confidence began to replace machismo and arrogance, and his best characteristics were finally able to shine through.

At the end of Season 5, while Izzie was undergoing cancer treatment, Alex and Izzie decided to get married. But soon after, Izzie decided that she didnt want to be with Alex anymore, and she took off, exiting the series (off-screen, Heigl asked to be released from her contract to spend more time with her family), abandoning the embryos theyd had frozen during her cancer treatments (or so we thoughtmore on that in a minute), and mailing him divorce papers.

Alex was understandably devastated, and still had a lot of growing up to do, but ultimately found his footing. He specialized in pediatrics and rose through the ranks to become an attending surgeon. He put his selfishness aside and invested in his friendships, to the point where he became Merediths local Person after Cristina departed at the end of Season 10. Several years (and many short-lived flings) later, he found himself falling for then-resident Jo Wilson, and after dating for a few years, decided to propose. They got married at the end of Season 14 in a ceremony officiated by Meredith Grey herself, and spent the next season and a half settling into married life. And although marriage came with its hardships, especially when Jo suffered a mental breakdown after discovering she was conceived as the result of sexual assault, he rose to meet them.

At the beginning of Season 16, when Jo fears that she is now too broken to be loved and offers Alex the opportunity to leave, he instead gets down on one knee and proposes to her all over again, promising that I want to grow old with you, no matter what.

Which would be a lot more meaningful if he did not leave her completely out of the blue just a couple short months later.

The writers of Greys Anatomy would have us believe that after everything he went through, including a relationship with Jo that lasted years longer than hed even known Izzie, Alex Karev would abruptly abandon his life partner for the woman who abandoned him a decade before. And who, apparently, secretly had his kids using frozen embryos he thought no longer existed. When he told Jo he was going to care for his sick mother, and subsequently sent a series of weirdly disinterested text messages to his wife and friends in Seattle, he was really going to visit Izzie and their kids on her farm. Where he then decided to remain, permanently.

No. I think not.

Right before he disappeared from the show, Alex also managed to snag the job of Chief of Surgery and Chief of Staff for the struggling Pacific Northwest Hospital, a huge accomplishment for the guy who once froze up during elevator surgery. But now hes tossing that away too, giving up the career hes worked so hard for.

I believe that the Alex Karev wed come to know by Season 16 would put his family before his career if he had to choose. I just dont believe hed choose Izzie over the family he was making with Jo. And since Jo would never have kept him from his kids with Izzie, he could have been a father, and kept his vows to his wife, and achieved professional success.

The Alex who would throw all of that away for Izzie isnt the Alex of Season 16. Its the Alex of Season 6, whose whole world revolved around Izzie, who didnt think much of himself as a doctor or as a friend, and who was frankly too immature to realize when he was making bad decisions. Perhaps the problem is that the show switched hands a couple times between, from Shonda Rhimes to Krista Vernoff, who took over for Rhimes as showrunner from 2007 to 2011. Vernoffs time on the series spanned Alex and Izzies marriage and Izzies subsequent departure, and she then returned as showrunner for Season 14. Maybe thats why it felt like Alexs Dear Jo exit was written for a character we havent seen in a decade. Maybe thats why it crumpled up 16 years worth of character development and tossed them in the garbage.

I think there could have been a scenario in which the writers wrote Alex off the show in a satisfying way, extenuating logistical circumstances and all. Maybe he died in an accident while visiting his mother, or even sacrificed himself saving a child. Maybe his mother, who hed already established was unwell, got confused and accidentally poisoned him, then panicked and faked his text messages to his wife and friends in Seattle, unable to deal with the trauma of his death. Maybe a thousand different scenarios (most, if not all, probably ending in death), none of which are living on a farm with Izzie.

But since we didnt get any of those endings, the best I can do for Alex is believe that the ending we did get is all a ruse. Maybe it wasnt Alex who wrote those letters and sent those uncharacteristic text messages at all. Maybe it was Izzie, seeing ghosts again, who somehow lured Alex to her farm, killed him, and buried him in the backyard. Maybe shes been impersonating him all along, writing the fictitious happy ending she wishes shed had.

It would suck. But given a choice between the death of Alex Karev and the assassination of his character, Ive got to go with death. At least it would be better than what we got.

Lauren Thoman is a Nashville-based freelance pop culture writer whose writing has appeared in numerous online outlets including Parade, Vulture, and Collider. She is also the author of the novel Ill Stop the World. Find her at her website, or on Instagram, Twitter, or Facebook.

For all the latest TV news, reviews, lists and features, follow @Paste_TV.

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It Still Stings: Grey's Anatomy Gave Alex Karev a Fate Worse Than ... - Paste Magazine

Anatomy

Grey’s Anatomy Fans Are Finally Ready To Admit Their Hate For … – Startefacts

He gets much better after season 5, but there's a catch.

There is a reason why many Grey's Anatomy fans fondly remember the previous seasons of the show.

Not only were viewers introduced to a whole new story of Seattle Grace Mercy West Hospital and its staff, but they were also introduced to a group of new interns whose dynamic would make the series a truly great story.

Although the cool name of the group gave it extra points, the beauty of MAGIC was how well the 5 flawed characters worked together.

Their conflicts, friendships and romances were incredibly interesting to watch and kept viewers glued to their screens.

Meredith Grey, Alex Karev, George O'Malley, Izzie Stevens, and Cristina Yang all made an impression on viewers that no future intern group could ever match.

However, as with any group, some characters stood out to fans a bit more than others, and some would get less recognition.

In MAGIC, George O'Malley always felt more like a supporting character than someone with an important storyline.

He was soft-hearted and generally nice, but despite his all-around positive qualities, he never got that many fans among the audience.

Only after rewatching the series many years later, viewers can finally understand why they never really liked George in the first place.

Like many other things from the '00s, his character aged like milk.

"I find the character George O'Malley to be insufferable, much worse than the on-the-surface-jacka** Alex. And Alex has turned a leaf later in season one and George ... Hasn't. George is whiny, insecure and he masks his insecurities by being misogynistic?? What the hell!" First-time-watcher CurrentPossession said on Reddit.

His whining, horrible attitude towards women, creepy remarks, and general behavior would make him completely unattractive to any audience today, which is probably why he doesn't get much praise from the fanbase anymore.

His story ends in a tragic accident in season 5, and to this day his death is often the only thing anyone remembers about his personality.

If you're up for a trip down memory lane, you can rewatch past seasons of Grey'a Anatomy on Disney Plus, ESPN Plus, and Hulu.

Or tune in to ABC on Thursdays to catch up on new episodes.

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Grey's Anatomy Fans Are Finally Ready To Admit Their Hate For ... - Startefacts

Anatomy

Two Episodes of Grey’s Anatomy Air Tonight – KSiteTV

ABC is airing two back-to-back episodes of Greys Anatomy tonight (April 13). The episodes are called Shadow of Your Love and Mama Who Bore Me, and in them, its Maggies last day. Amelias relationship with Kai is tested, and Ben worries as Baileys doxing intensifies. With Levis help, a patient celebrates a milestone.

Additionally, Jo processes a difficult diagnosis, and Maggie and Winston decide their future. You can see photos from both of the episodes below; the action starts at 9PM ET/PT.

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GREYS ANATOMY - Shadow of Your Love/Mama Who Bore Me - Its Maggies last day. Amelias relationship with Kai is tested, and Ben worries as Baileys doxing intensifies. With Levis help, a patient celebrates a milestone. Jo processes a difficult diagnosis, and Maggie and Winston decide their future. THURSDAY, APRIL 13 (9:00-11:00 p.m. EDT), on ABC. (ABC/Raymond Liu)ANTHONY HILL

Recipient of the 2007 Golden Globe Award for Best Drama Television Series and nominated for multiple Emmys, including Outstanding Drama Series, Greys Anatomy is considered one of the great television shows of our time. The high-intensity medical drama, now in its 19th season, follows Meredith Grey and the team of doctors at Grey Sloan Memorial who are faced with life-or-death decisions daily. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white.

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Two Episodes of Grey's Anatomy Air Tonight - KSiteTV

Anatomy

Grey’s Anatomy’s Best Casting Decision Was Almost an Accident – Startefacts

It's hard to imagine Sandra Oh playing anyone other than Cristina now, but it could have been different.

Grey's Anatomy was established as a true-to-life show, with characters you could easily meet in any medical center.

But what was even more important to the show's creator, Shonda Rhimes, was creating a strong group of female characters, each of whom was multifaceted.

And one of the first female characters she wrote was actually Cristina Yang, who ended up being portrayed by Sandra Oh. In the show, Yang is represented as a real woman with a lot of sides to explore.

"She's the kind of woman I know really well, and I like her. There's something interesting about a person who is that driven, a little bit emotionally disconnected but still a caring, sweet, and smart individual," Rhimes said in an interview with Oprah Winfrey.

Sandra Oh played Cristina for 10 seasons. However, it turned out that she had originally auditioned for another role. During the casting she read for the role of Dr. Miranda Bailey.

But apparently she was happy that she didn't end up playing her. Later in the interview with Oprah, she said that she couldn't imagine anyone but Chandra Wilson playing Bailey in the end.

But there's more. It was revealed that Oh never had a real desire to play Bailey.

When the writers offered her the role, she simply asked what else she could choose at the time and if there were any characters left that were not cast. And then she found out that she could audition for Cristina Yang's role.

As Sandra later explained in Lynette Rice's tell-all book How to Save a Life: The Inside Story of Grey's Anatomy, what she really wanted was to play a person who is still in a learning process, the person who is eager to find out something.

Oh also revealed that she was interested in playing someone controversial. And indeed, her character was initially shown as an antagonist, and a rather feisty intern.

But thanks to Oh's performance, her character evolves into a complex one with a lot to offer viewers, and her departure in season 11 was received with regret by fans.

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Grey's Anatomy's Best Casting Decision Was Almost an Accident - Startefacts

Organic Chemistry

Helicenes are the ‘first true organic electrocatalyst’ for carbon … – Chemistry World

Helicene electrocatalysts offer a metal-free way to convert carbon dioxide into valuable chemicals. The catalysts drive the process up to 1000 times faster than other organic compounds and represent the first example of a true organic electrocatalyst for carbon dioxide reduction, according to the researchers who developed them.

The team led by Joyanta Choudhury at the Indian Institute of Science Education and Research in Bhopal, found inspiration in the way plants convert carbon dioxide into carbohydrates. Our synthetic molecules mimic the NADP/NADPH system, [in terms of] the central pyridine ring structure and function, he explains.

In photosynthesis, NADPH is a cofactor that efficiently transfers hydrides to captured carbon dioxide molecules, a key step in the formation of sugars and biomass. Over the years, organic hydrides have been used in the reduction of substrates like alkenes, imines, and carbonyl products, adds Choudhury. In this case, Choudhurys team designed a hydride donor based on a helicene structure, to create an artificial NADP analogue that drives the electrocatalytic conversion of carbon dioxide into formate ions.

These organic analogues offer several advantages, among them stability and tuneability. Because of their simpler structures, NADP analogues are also easily accessible in the lab, says Choudhury. Moreover, structural modifications [allow us] to tune their reactivity at wish, he adds.

It features [up to] 1000-fold enhancement of the existing turnover values for similar organic compounds

Joyanta Choudhury,Indian Institute of Science Education and Research, Bhopal

The helicenes are prepared in a one-pot reaction from simple starting materials. Most importantly, the team has reduced the amount of helicenes used in the electrochemical conversion of carbon dioxide to around 1% which is considered a catalytic quantity. It features [up to] 1000-fold enhancement of the existing turnover values for similar organic compounds, adds Choudhury.

Its a significant improvement, and proof of a catalytic system, says Carla Casadevall, an expert in artificial photosynthesis at the University Rovira i Virgili and ICIQ in Tarragona, Spain. Apart from offering a metal-free alternative, [helicenes] regenerate electrochemically following a bio-inspired proton-coupled electron-transfer, she says. Its this process that allows the unusual boost in activity observed. The rational structural design of the helicenes improved its stability and consequently [that of] the electrochemically generated intermediates, she adds.

Although the catalytic process is metal-free, some of the demonstrations required electrodes based on hazardous elements, including mercury. Nevertheless, the authors have also proven the reaction works with simple glassy carbon electrodes, explains Casadevall. This technology is widely used in electrochemistry and had previously been successful in carbon reduction experiments.

According to Casadevall, the next challenges will be to improve the efficiency decreasing the overpotential of the electrocatalytic carbon dioxide reduction and recyclability of the system.

The high overpotential and the stability for long-term electrolysis are still issues to address, acknowledges Choudhury. Currently, the team is attempting to solve these issues by modifying the backbone of the helicene catalyst and adjusting the reaction conditions. Choudhury also notes that the team is exploring applications of helicenes in catalysis beyond electrochemistry, including a photochemical strategy for carbon dioxide reduction.

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Helicenes are the 'first true organic electrocatalyst' for carbon ... - Chemistry World

Organic Chemistry

UM-Flint alum, Citrucel inventor, shares experience with chemistry … – University of Michigan-Flint

A University of Michigan-Flint alum known for his invention of Citrucel and being one of the top 40 most cited scientists in his field recently visited campus and gave a lecture about his love of chemistry and his discoveries in nanomedicine and nanotechnology.

Donald Tomalia, who is originally from Flushing, shared his life story with students and faculty and gave a detailed account about what led him to become a chemist.

"As long as I can remember, I've been curious about what life is, how it works and what its purpose is. Since chemistry is focused on the dynamics, behavior and composition of all matter in the universe, it seemed logical that chemistry would help me find those answers."

After graduating from high school, Tomalia set out in earnest to find those answers. He earned his bachelor's degree in chemistry from UM-Flint in 1961 and then went on to earn a master's degree in the same subject at Bucknell University the same year. After receiving his graduate degree, he began working in the research and development department at Dow Chemical Company where he invented the dietary supplement known as Citrucel in 1962. He went on to receive a PhD in physical-organic chemistry from Michigan State University in 1968 while he was still working at Dow.

Transitioning to a new role as a research fellow at Dow, Tomalia began researching how to create synthetic molecules and polymers that mimicked the growth and appearance of a tree, including its trunk, branches and leaves. This research led to his discovery of dendrimers. Today, dendrimers are found in therapeutic cancer drugs, antiviral agents that protect people from COVID-19, antiviral therapies for HIV and HPV as well as delivery of agrochemicals that enhance crop yields.

As his time at Dow ended, Tomalia launched his first startup company, Dendritech, in 1992. Dendritech, which would be acquired by Dow just six years later in 1998, supplies dendrimers for a device used to diagnose acute heart attacks in less than five minutes as well as anti-fouling paint, or specialized coating applied to ships and boats to slow growth of algae or other aquatic organisms.

His next startup, Dendritic Nanotechnologies was founded in 2001. The company, acquired by Australia's Starpharma in 2006, uses dendrimers to enhance cancer treatment drug delivery, thereby ensuring the drug reaches the right part of the body at the right time.

Tomalia's current company, NanoSynthons LLC, founded in 2010, focuses on the development, production and distribution of high-quality, well-defined carbon molecules.

Tomalia says that his discoveries of dendrimers and building his companies have been a journey.

"I use the term 'journey' as a code word for learning," he said. "I've learned so much along the way. I never thought I would have discovered something as important as dendrimers.'

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UM-Flint alum, Citrucel inventor, shares experience with chemistry ... - University of Michigan-Flint

Organic Chemistry

expert reaction to study looking at volatile organic compounds in a … – Science Media Centre

April 12, 2023

A study published in Cell Reports Physical Science looks at volatile organic compounds in a vehicle cabin environment.

Prof Oliver Jones, Professor of Chemistry, RMIT University in Melbourne, Australia, said:

This is a detailed study that seems to have been conducted thoroughly, in a real-world environment rather than a lab. The authors built a predictive model of the release of the chemicals that cause new car smell and then tested the predictions against measured concentrations.

Many of us like new car smell (myself included). This study doesnt look at health effects of these chemicals, but we know from previous research that some of these chemicals arent really good for us.

New car smell is the result of a chemical process called off-gassing. The term doesnt sound appealing, but it just means the airborne release of a chemical or chemicals as a vapour, in this case from materials such as plastics and adhesives in the cars interior. Such chemicals can include acetaldehyde, benzene, formaldehyde, hexanal, and styrene. Many of these compounds are listed as carcinogenic (cancer-causing), but then so are sunlight and alcohol. It is the dose that makes the poison just because something is present does not automatically mean its a problem; its about quantity (even water is toxic if you drink enough of it). The current paper is focused on ways to better model how much of the chemicals that cause new car smell might be released over time in a car under different conditions.

That said, new car smell is not without risks we know from previous research that for some people it can cause health problems such as dizziness, nausea, and shortness of breath. Healthwise the best new-car smell is probably no smell.

The fact that higher temperatures increase the rate of off-gassing from materials is not new but what is interesting here is that the authors use the surface temperature of the materials to predict the amount of compound that might be released over time rather than the more commonly used metric of air temperature in the cabin. This makes sense when you think about how hot the seats and the steering wheel can get on a hot summer day, especially in places like Australia. A more accurate model gives us a better idea of the likely levels of potentially harmful chemicals over time and this gives us a better idea of the risks which can only be a good thing for drivers.

Observation, prediction, and risk assessment of volatile organic compounds in a vehicle cabin environment by Haimei Wang et al. was published in Cell Reports Physical Science at 16:00 UK time on Wednesday 12 April 2023.

DOI: 10.1016/j.xcrp.2023.101375

Declared interests

Prof Oliver Jones: I have no conflicts of interest to declare.

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expert reaction to study looking at volatile organic compounds in a ... - Science Media Centre

Organic Chemistry

How to help students identify electrophiles and nucleophiles – Education in Chemistry

Students need to have a fluency across a range of concepts and skills to gain a secure grasp of organic chemistry. In terms of reaction mechanisms, research has shown that learners frequently have trouble identifying electrophiles and nucleophiles in reactions. Its particularly difficult for students to recognise the relationship between the pictorial depiction of reaction mechanisms and the underlying understanding of electron-deficient and electron-rich species.

Much research in this area has involved interviews with relatively small sample sizes. In a recent study, researchers evaluated nearly 20,000 written explanations of what occurs, and why, in reaction mechanisms to shed further light on students understanding of the processes involved.

Electrophiles, which are electron-deficient, are electron-seeking species.Nucleophiles, which are electron-rich, are nucleus-seeking species. The properties of a given species may be explicit, being depicted pictorially in the form of formal charges, labelled dipoles and lone pairs.

Students perform better in identifying electrophiles and nucleophiles where such explicit features are depicted, but they struggle where properties are implicit (not depicted pictorially). Species with negative charges and/or lone pairs may be easily identified as nucleophiles, while positively-charged species may be identified as electrophiles. Pi-bonds (explicitly depicted) and even some sigma bonds (eg, AlH bonds in LiAlH4), which can be thought of as shared pairs of electrons, have nucleophilic character and can therefore react with electrophiles.

In a chemical reaction, electrophiles and nucleophiles are complementary. An electrophile interacts with a nucleophile during a reaction and vice versa. In previous studies, students were more likely to correctly identify a nucleophile than an electrophile in a reaction.Since chemists need to be able to explain how and why two species interact in a reaction mechanism, its vital they can rationalise the roles of both reacting species. This then facilitates the prediction of the products for a specified reaction.

Students are often asked toreproduce a pictorial reaction mechanism in assessments, which can potentially be rote-learned, resulting in poor understanding of the underpinning theory.Instead, the researchers present a strong case forassessing theexplanation of the mechanism in terms of the interaction between nucleophile and electrophile.

Being able to explain whats happening at a molecular level is the key to understanding the processes involved in a reaction mechanism

The authors created a two-part rubric to evaluate the sophistication of students explanations about electrophiles. This complements a similar rubric they created for nucleophiles. Students had to describe the sequence of events occurring during a reaction mechanism in terms of the roles of reactants and intermediates, and explain their interaction at the molecular level.

The authors created a two-part rubric to evaluate the sophistication of students explanations about electrophiles.Students had to describe the sequence of events occurring during a reaction mechanism in terms of the roles of reactants and intermediates, and explain their interaction at the molecular level.

The researchers categorised the sophistication of student explanations as: absent, descriptive, foundational or complex. Across both electrophiles and nucleophiles, over 54% of responses were classified as descriptive, while nearly 20% were classified as absent, showing room for improvement. Around 54.5% of explanations were at the same level of sophistication for both electrophiles and nucleophiles, and where there was a difference, there was a clear pattern that the electrophile level was lower than the nucleophile level, in line with previous studies.

Being able to explain whats happening at a molecular level is the key to understanding the processes involved in a reaction mechanism. Providing a narrative to accompany the mechanism will help students correctly draw it from first principles.

Reference

Stephanie J H Frostet al,Chem. Educ. Res. Pract., 2023,24, 706-722 (DOI:10.1039/D2RP00327A)

David Read

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How to help students identify electrophiles and nucleophiles - Education in Chemistry

Organic Chemistry

[WEBINAR] Scalable Oligonucleotide Manufacture With Stirred-Bed … – Contract Pharma

Based on decades of experience in applying stirred-bed reactors for making peptides, we investigated whether thesecould be used for the manufacturing of oligonucleotides aswell. Join our webinar on scalable oligonucleotidemanufacturing with stirred-bed technology (SBT) to learn howwe can reach commercial oligonucleotides API production inmetric ton range with unbeaten process mass intensity. You willget insights into case studies, our SBT capacities for R&D tolarge scale production projects, and typical CMC activities forscale-up. Finally, we will share the distinct advantagesstirred-bed solid-phase oligonucleotide synthesis (SPOS) hasover classical fixed-bed SPOS.

Speakers:

Daniel Samson, PH.D. - Vice President, Head Oligonucleotides

Daniel brings 15 years of industry experience to the team, with an emphasis on TIDES process R&D, manufacturing and CMC development. He leads Bachems oligonucleotide unit including innovation projects, R&D and manufacturing activities. Daniel holds a PhD in organic chemistry from the University of Konstanz, and an MBA from the International Institute for Management Development (IMD), Lausanne. In previous stages of his career he was a lab head for process optimization, technology transfer, Quality by Design, and scale-up of synthetic peptide manufacturing procedures. From 2012, Daniel was a Vice President API Manufacturing and had full responsibility for all large-scale solid phase peptide and oligonucleotide syntheses, downstream operations, and CMC activities within Bachem AG.

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Chris leads the Global Business Development department at Bachem. Previously, he was Senior Director of Business Development (BD) for Bachem Americas. As Senior Director of BD, he was at the forefront of communications related to the development and manufacturing of new peptide and oligonucleotide-based chemical entities with his team of peptide experts in the field. Chris has nearly a decade of experience at Bachem and previously earned a Ph.D. in organic chemistry from the University of California, Irvine.

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[WEBINAR] Scalable Oligonucleotide Manufacture With Stirred-Bed ... - Contract Pharma