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Post-doctoral Fellow in Bioinformatics in the Cancer Biology … – Times Higher Education

Work type:Full-time Department:Department of Pathology, School of Clinical Medicine (21200) Categories:Senior Research Staff & Post-doctoral Fellow

Applications are invited for appointment asPost-doctoral Fellow in bioinformatics in the Cancer Biology Laboratory(Ref. 523403),to commence as soon as possible for three years, with the possibility of renewal subject to satisfactory performance.

Applicants should have a Ph.D. degree, preferably in Computational Biology, Bioinformatics, Biomedical Sciences, Biological Science, or a related discipline. Applicants should be familiar with, UNIX environment, computer programming and R language. Preference will be given to those with strong experience in cancer biology, genome biology, and next-generation sequencing analysis. Applicants should be self-motivated, organized and able to work independently as well as in a team. The appointee will work with Dr. Carmen Wong on liver cancer projects with NGS and single cell RNA sequencing analysis. Enquiries about the post should be sent to Dr. Carmen Wong atcarmencl@pathology.hku.hk. Further details about the research team can be find in our webpage (www.carmenwong-lab.com).

A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits.

The University only accepts online application for the above post. Applicants should apply online and upload an up-to-date C.V. Review of applications will start on October 20, 2023 and continue untilDecember 31, 2023, or until the post is filled, whichever is earlier.

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Post-doctoral Fellow in Bioinformatics in the Cancer Biology ... - Times Higher Education

Research Fellow, Biology job with MAYNOOTH UNIVERSITY | 354742 – Times Higher Education

Department : Biology Vacancy ID : 025483 Closing Date : 05-Nov-2023

Maynooth University is committed to a strategy in which the primary University goals of excellent research and scholarship and outstanding education are interlinked and equally valued.

The Family Genomics research group led by Dr Lorna Lopez, in collaboration with behavioural neuroscientist Professor Andrew Coogan at Maynooth University invite applications for the position of Research Fellow on our Ambient-BD research project.

This project is led by the University of Edinburgh with co-investigators at Maynooth University, Ireland and the Technical University of Munich, Germany. It is funded by the Wellcome Trust (2023-2028).The purpose of Ambient-BD is to investigate the role of variability in long-term circadian rhythms in the trajectory of disease in people with bipolar disorder.

The initial development and validation studies will be carried out in Maynooth University and the clinical studies in people with bipolar disorder completed at the University of Edinburgh. There will be considerable collaboration between the two research sites throughout the project.

Bipolar disorder is defined by extreme variability in mood, activity, sleep and circadian timing recurring over weeks and months. The purpose of Ambient-BD is to optimise innovative ambient and passive methods for collection of circadian data and to test their feasibility and performance against gold standards. A lived experience advisory panel will help us to identify and prioritise clinical and functional outcome measures to co-produce low intensity methods for collecting these outcomes. In parallel, we will develop a data collection and data management system to support data collection and optimise data sharing with patients, clinicians and the research community. Our goal is to identify causal mechanisms by which sleep and circadian disruption leads to relapse in bipolar disorder. We will also deliver an innovative programme of knowledge exchange and dissemination in collaboration with Bipolar Scotland

We are seeking an enthusiastic and ambitious research fellow to join our research team to manage studies to develop novel methods for assessment of circadian rhythms. The successful candidate will work with us on cutting-edge research projects that focus on understanding how changes in the variability of circadian rhythms relate to human health and disease.

The research fellow will find ample opportunities to collaborate via our membership of circadian research collaborations in the UK, https://www.circadianmentalhealth.org/. They will be given support to develop their independent research career, including help with fellowship applications, building collaborations and research placements in other research groups.

This position is embedded in a collaboration across genetics, data science, chronobiology and psychiatry and the successful candidate will become a part of a large team of lived-experience advisors, patient advocates, PIs, postdocs, PhD students and research assistants working together to drive the field of chronopsychiatry forwards.

Salary

Research Fellow (2023): 61,318 63,096 p.a. pro-rata. (2 points with increment)

Appointments will be made in accordance with public sector pay provisions

Closing Date: 23:30hrs (local Irish time) on Sunday, 05th November 2023.

Please note all applications must be made via our Online Recruitment Portal at the following link: https://www.maynoothuniversity.ie/human-resources/vacancies

Please apply with your CV and a Cover letter that includes a brief summary of the following:

Applications must be submitted by the closing date and time specified above. Any applications which are still in progress at the closing time on the specified closing date will be cancelled automatically by the system.

Late applications will not be accepted.

Maynooth University is an equal opportunities employer

The position is subject to the Statutes of the University

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Research Fellow, Biology job with MAYNOOTH UNIVERSITY | 354742 - Times Higher Education

Lakebound but Unbroken: Jason Voorhees’ Biological Resilience … – The Rampage

Imagine the icy grip of Crystal Lake's water enveloping you as you wade deeper. The moonlight barely pierces the surface, casting eerie shadows on the lake bed. The air is thick with the scent of damp earth and decaying leaves. Your foot brushes against something unsettling below. You lock eyes with a hollow gaze behind a hockey mask. Your heart pounds. Welcome back to Fear By the Numbers, where we dissect the science behind your darkest fears. Today, we're diving into the enigmatic Jason Voorhees of the Friday the 13th franchise, exploring how this horror icon could theoretically survive underwater for extended periods in the depths of Crystal Lake.

Before becoming the embodiment of nightmares, Voorhees was a child with physical and mental impairments, shunned by society. Been thought to have drowned two decades prior, Voorhees emerges from the lake to exact his machete-wielding revenge upon his tormentors.His near-drowning at Camp Crystal Lake was a pivotal moment, setting the stage for his transformation into an unyielding force of terror.

Crystal Lake is no ordinary body of water. The lake's water is as murky as its history, a dark abyss that seems to swallow light itself like a living entity, silently aiding his transformations

Its unique ecosystem, characterized by low oxygen levels and high sediment concentration, is a breeding ground for extremophiles organisms that thrive in extreme conditions.

But what transpired during those submerged years? Could his physiology have adapted in ways that defy our understanding of human biology and could we all harbor a dormant monster within us? Can science explain the inexplicable?

The idea of rapid healing has always fascinated me. Given the unique conditions of Camp Crystal Lake, could Voorhees cells be mutating, evolving and becoming something not entirely human? Are human cells capable of that? In Biomolecular Action of Ionizing Radiation by Shirley Lehnert, she explains that ionizing radiation, commonly used during X-rays, can cause significant changes at the cellular level with extended exposure, affecting DNA structure and repair mechanisms.

Further, a study by Coralie Trentesaux and colleagues titled Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity discusses DNA damage repair and survival under stress conditions. These ideas could explain how the distinct conditions of Camp Crystal Lake have influenced Voorhees' microbiota the community of microorganisms living inside him to adapt. This adaptation could enable him to survive with low levels of oxygen, much like certain deep-sea creatures. If he can survive with minimal oxygen, what's stopping him from lurking in your closet, silently waiting? It's a question that makes me double-check my locks at night.

Now, let's get into a probability model I've developed known as the "Voorhees Viability Index" to calculate the likelihood of human survival under extreme conditions. Utilizing Bayesian probability, which uses expectation or personal belief in calculating probabilities, the VVI takes into account the unique environmental factors of Crystal Lake. It also factors in human physiology, drawing from documented cases of extreme survival.

According to the VVI, the probability of a human adapting to such conditions is a staggering 0.0001%. To put this in perspective, using this model, the odds of being struck by lightning are 0.0002%. While these numbers may seem minuscule, they are not zero. In the realm of theoretical biology, that's enough to keep me and hopefully you wondering.

Jason Voorhees is not a static character; he's an evolving entity. From a vengeful son to an almost supernatural force, his character arc could be a reflection of his biological evolution. Each resurrection might not just bring him back but make him stronger, more resilient, and more adapted to extreme conditions.

As we dissect the biological possibilities behind Jason Voorhees, we're reminded that science can be as fascinating as it is unsettling. The line between scientific curiosity and morbid fascination blurs, leaving us with questions that might be better left unanswered. While we may never fully decode the mystery of his survival, one thing is clear: the next time you find yourself near Crystal Lake, you'll think twice before venturing into its depths. And even then, will you ever be truly alone? What if the science we trust to explain the world around us is the very thing that unlocks doors best left sealed, inviting nightmares into our reality that we can never escape?

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Lakebound but Unbroken: Jason Voorhees' Biological Resilience ... - The Rampage

June 30 Zodiac: Sign, Traits, Compatibility and More – AZ Animals

Were you born on June 30th? Then your sun sign is Cancer in Western astrology. A sun sign is only one small part of your natal astrological chart, but it has become the most popular part of astrology because it is easiest to determine. Sun signs are based on the dates the sun moves through certain constellations each year. These dates are relatively the same year after year, so anyone born between June 21 and July 20 is also a Cancer.

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The other aspects of astrology, such as your Moon sign, Mercury sign, or Venus sign, are determined by the exact time and place of your birth. The planets closest to the sun are known are your personal planets because they are different for each person.

The outer planets like Pluto and Saturn, are the same for every person in a generation. Because of their longer orbits, they can sometimes take years to move through signs. However, each person has these planets placed in a different house in the astrological chart, which still gives them differing meanings for their life and personality even if they have the same sign as their peers.

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The zodiac sign Cancer is represented by the crab. This is a great symbol for Cancers for many reasons.

June 30 birthdays are in the first decan of Cancer. A decan is a smaller section of an astrological sign that takes up about 10 days. The first decan of Cancer is from June 21-July 1. Those born during this time are classic Cancers. They are quite romantic, love their families, and can be quite creative.

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Cancer is the only sign to be ruled by The Moon, and only one of two zodiac signs to be ruled by a luminary instead of a planet. The other one is Leo, which is ruled by The Sun. Cancers relationship to the moon is somewhat different from other signs relationships to their planets, simply because the moon is so much closer and we are deeply connected to it here on Earth.

The Moon has a direct effect on our Earths tides. Humans have used the phases of the moon to help us tell time for thousands of years. In the English language, several words that relate to periods of about a month are derived from words relating to the moon. For example, the words month and menstrual are related to The Moon. Throughout history, people have also thought The Moon has different effects on human behavior leading to words like lunacy and lunatic.

Cancers emotional nature may be related to The Moon. Cancers can seem, to others, to have random mood shifts that dont make much sense to others. However, they can be related to the changing phases of The Moon and the other astrological aspects of The Moon as it orbits our planet.

The Moon also deals with empathy and intuition. Because of this, Cancers are strong in both of these traits. A healthy Cancer can empathize with other people but still maintain their own identity. An unbalanced Cancer may become overly identified with other peoples feelings and get confused about what feelings belong to other people and what belongs to themselves.

Because of their connection to the moon, Cancers are also so intuitive that they can seem to be psychic. Never try to lie to a Cancer because they will probably simply sense that youre lying. However, as previously mentioned, this can lead them to get upset when their friends and family dont read their mind.

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All water signs are deeply emotional and intuitive, but in different ways. The other two water signs are Scorpio and Pisces. People tend to think water signs are total emotional softies. However, you only have to think of the element water to know that is not true. Water can trickle pleasantly through a stream, or stall in a river to create the perfect swimming hole. However, it can also rage and cause great destruction. Additionally, water is so powerful that over thousands of years it carves canyons and creates shorelines. All this is to say: dont underestimate a water sign.

Water signs also love stability. For Cancers, this can result in long-term partnerships, loyal friendships, living in the same home for a while, and having the same job in a traditional setting for quite some time. However, this can also mean that when things are not stable they can become more fragile than other people who deal with change more easily.

Every sign of the zodiac is either fixed, mutable, or cardinal. Each of the four elements, water, air, fire, and earth, represents three signs. Each of the three aspects fixed, mutable, and cardinal, represents four signs. So, each element has one fixed sign, one mutable sign, and one cardinal sign.

Cardinal signs like Cancer come at the start of each season. Because of this, they are considered the leaders of the zodiac. They are trendsetters and love to come up with innovative ideas. Cancers cardinal nature may be more under-the-radar than the others because of their watery nature. However, its simply that their leadership qualities may not appear in the things that we value most in our current societys structure. They are more likely to take the lead in spiritual, emotional, and home pursuits.

People born on June 30th have both the number 3 and the number 9 as part of their important numbers. The number 3 comes from the day of the 30th. So, they share this number with people born on the 30th of any month. Number 3s can be funny and social. To others they can appear to be irresponsible, but they always handle their affairs. Its just that they never think anything is so serious to get super worried about it.

The number 9 comes from the month (6) and the day (30th). The number 9 encompasses a bit of the qualities from all of the other numbers in numerology. It is the last number because in numerology you always simplify any double or triple digits down to a single number. So, people with this number in their life are often flexible and adaptable. They can learn multiple strategies for how to deal with a problem and use the one that works best for the situation.

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Each of the birthstones for the month of June fit well into Cancers ethos. There are three choices:

Pearl and moonstone both look like the moon, which Cancer has such a deep connection with. Alexandrite is a mystical rare gem that changes color depending on what type of light shines on it.

Each sign in the zodiac has stereotypical personality traits. However, its important not to pre-judge people based on these ideas. You can use them to explain someones behavior, but they show up quite differently in different people. When unbalanced, any sun signs more challenging traits can come out. When they have worked on themselves, any signs more easeful traits can be present. Also, what is a challenging trait for one person, may be a desirable one for someone else. For example, Cancers love of staying at home could be challenging for an adventure oriented sign like Aries or Gemini, but a dream for another comfort loving sign like Taurus. All this is to say, these traits are just stereotypes. Let a Cancer show you who they are before you assume anything about them!

Like all water signs, Cancers feel deeply. They are also quite sensitive. They may not take kindly to good-natured teasing or constructive criticism. Because of this, Cancers need to learn that things arent always personal. Learning to take criticism, especially in work and school, can help Cancers become happier and more well-adjusted people.

For all their emotions, Cancers tend to retreat into their shells when they are in their feels, rather than expressing them. Part of this is a desire to avoid confrontation, and part of this is that Cancers forget that people arent as psychic and intuitive as they are. They expect their people to read their minds. This can lead to passive-aggressive behaviors where Cancers drop hints that they are upset, but never really say what is bothering them. Additionally, as the emotional world is the realm in which Cancers feel most comfortable, they can forget that there is a conflict or issue to deal with. They can focus on their feelings and dig into them, even wallowing, rather than sorting things out.

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Cancer, especially those in the first decan, has a special interest in family. In our modern world, this doesnt have to mean their family of origin. It can be a family of choice. They love to nurture and care for their family members. June 30th Cancers may have a special interest in fertility or having their own children because the first decan is ruled by Venus. This also ties into their love of home, which is often where their family is located.

Cancers are loyal friends, family members, and romantic partners. It is hard to get into their inner circle, but once youre there, a Cancer will have a hard time letting you go. Their home can become a center for the friend group, and they love hosting for those who are important to them. However, there are some challenging aspects to this loyalty that can develop. Cancers are so nurturing and loyal that they can forget about their own needs in a relationship. This can lead them to overextend themselves, leading to resentment in the long-term, especially if their nurturing is not reciprocated.

Cancers also have a tendency to hold onto objects, in addition to people. This can lead to a comfortable but cluttered home.

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Cancers love stability so they may prefer traditional employment versus being self-employed. They do well in jobs where they can nurture others such as childcare, nursing, mental healthcare, and teaching. However, there are also some unconventional ways that they can show their nurturing nature through their work such as becoming a financial planner, interior designer, or office manager. Cancers can also put their amazing intuition to work as an esoteric practitioner such as a tarot reader or astrologer.

If youre looking for a committed relationship, then something with a Cancer is right up your alley. However, if you want something casual, then Cancers desire for loyalty, stability, and commitment will probably send you running for the hills. Cancers are super romantic and prefer to be in long-term relationships. They make great partners, and can build an amazing home and family with someone who wants the same thing.

Because of their loyalty to their partners and friends, Cancers can easily overlook problematic aspects of their partners. On the one hand, this can be a good thing. They are not likely to break up with someone over small behaviors that annoy them. On the other hand, when it comes to more serious topics like disrespect or even abuse, a Cancer can stay in a relationship for way too long.

Additionally, because they value loyalty and longevity so much, they are likely to stay friends with their exes. New partners may feel jealous of these friendships.

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Cancers are possibly most compatible with Scorpios and Tauruses. Scorpios feel just as deeply as Cancers, and may even feel more deeply. They also love commitment and are looking for a true soul connection in their relationships. Tauruses are equally stable and huge fans of comfort. A home built by a Cancer/Taurus relationship is going to be very cushy and inviting!

Fire signs might be least compatible with Cancers. Aries, Sagittarius, and Leo love adventure and might not stay in the same place long enough for a Cancers liking.

The symbol of the crab comes from an ancient Greek myth. The star of the myth is Heracles, the Greek version of Hercules. The Greek goddess Hera hated Heracles because he is the result of an affair between her husband, Zeus, and the mortal princess Alcmene. His existence reminded her of Zeus constant wandering from their relationship. So, when Heracles was fighting a nine-headed hydra, she sent a giant crab to mess with him. Unfortunately for Hera and luckily for Heracles, he easily killed the beast. So, Hera immortalized the crab in the stars as a constellation.

The Moon was also an important symbol in Greek mythology. Selene, the goddess of The Moon, was a romantic deity who was also very family oriented, just like Cancer. She had more than 50 children! She was also associated with intuition and psychic visions.

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June 30 Zodiac: Sign, Traits, Compatibility and More - AZ Animals

Indiana’s Funding Ban for Kinsey Sex-Research Institute Threatens … – The Chronicle of Higher Education

The decision to ban state funding for Indiana University at Bloomingtons famed sex-research institute threatens academic freedom and sets a troubling precedent for legislative interference in research nationwide, the universitys president, Pamela Whitten, said in a recent public statement. The ban, included in the state budget after a heated debate, was inspired by a conservative lawmakers unproven claims, based on decades of circulated rumors, that the Kinsey Institutes founder had promoted pedophilia and that the institute endangered children.

The state doesnt allocate any money directly for the institute, which receives the vast majority of its funding from grants and outside philanthropy, so the impact of this specific prohibition will be mostly administrative and symbolic. The state simply gives money to the university, which until now, it could spend on the institute.

The institute was founded in 1947 at the Bloomington campus as the Institute for Sex Research. Its founder, Alfred C. Kinsey, was an American biologist and professor of entomology and zoology who had been teaching a college course on marriage and was surprised by how little his students knew about sexuality. After founding the institute, he and his team collected and studied thousands of sexual histories. Kinsey, who died in 1956, rose to national prominence after the publication of his books Sexual Behavior in the Human Male in 1948 and Sexual Behavior in the Human Female in 1953.

In the former, he argued that human sexuality existed on a continuum from heterosexual to homosexual, and that people didnt neatly fit one or the other. Because Kinseys research included extensive interviews with at least one pedophile, his fiercest critics accused him of encouraging sexual deviancy. Others questioned his research methods and data.

In the second book, Kinsey examined the sex life of American women, which outraged many 1950s readers with its findings about the frequency of premarital sex and masturbation. Congressional critics accused the Rockefeller Foundation of contributing to the nations moral decay by funding the research. It stopped doing so in 1954, two years before Kinseys death.

Among the contemporary topics the institute studies are issues related to reproductive health, sexually transmitted disease, teen pregnancy, and sexual abuse. It also delves into relationships and dating. Researchers should be protected from interference with such work, the universitys president wrote in a prepared statement last month.

As a premier research institution with a 200-year legacy of impact within our state and around the world, IU is firmly committed to academic freedom, Whitten wrote. The university is concerned that a provision singling out a specific research institute sets a troubling precedent with implications that could limit the ability of public colleges and universities to pursue research and scholarship that benefits people and improves lives.

She went on to say that the university will conduct a thorough legal review to ensure it follows state law and added that its committed to the ongoing crucial research and robust scholarship conducted by IU faculty and the Kinsey Institute. In a letter to faculty and staff members, Whitten and other top campus administrators said the university will continue to support the institutes faculty in finding and securing the research grants and private philanthropic support that already make up the vast majority of its funding.

The budget signed by Eric J. Holcolm, Indianas Republican governor, specifically prohibits state money from being used to cover the institutes on-campus facilities, research work, utilities, office supplies, and maintenance of research photographs or films.

The stipulation banning state spending on the Kinsey Institutes work was introduced by Rep. Lorissa Sweet, a Republican from Wabash. She introduced it as an amendment to the proposed budget because of her objections to the institutes founder, whom she accused on the House floor of exploiting children through interviews with adults talking about how children experience orgasm. Sweet, who did not respond to requests for comment, also suggested that the institute continues to support sexual abusers, a claim that has never been proved.

On its website, the institute urged its supporters to take to social media and other channels to defend the right to conduct sex research. The budget restriction takes aim at the very foundation of academic freedom and stifles critical research on sexuality, gender, relationships, and reproduction, it said.

Since 1947, the Kinsey Institute has been an international thought leader in providing an unbiased and apolitical scientific approach to human sexuality, the website post said. In this time of divisive politics and the rise of disinformation, Kinsey Institute research, education, and historical preservation are more important than ever.

The university did not make the president or the institutes executive director, Justin R. Garcia, available for interviews, but it referred The Chronicle to an opinion piece published this week in The Washington Post thats also posted on the institutes website.

For generations, the Kinsey Institute has shone a light on diverse aspects of sex and sexuality, in pursuit of answers that bring us closer to understanding fundamental questions of human existence, Garcia, who is a senior scientist at the institute and also a professor of gender studies, wrote. Sweet, the lawmaker who introduced the budget amendment, had parroted false allegations of sexual predation in the institutes historical research and ongoing work, which the institute, the university, and outside experts have repeatedly refuted.

Rep. Matt Pierce, a Democrat whose Bloomington district includes the flagship campus, said, These same unproven allegations about Kinsey were circulating about 20 years ago. Really crazy stuff about Kinsey experimenting with children and babies that were circulating in these conservative culture-war stories. The reports were being recirculated because of a 1998 book by a conservative author, Judith A. Reisman, that accused Kinsey of shaking the nations moral foundation with dangerous research and exploitive experiments on children.

Pierce, who is also a senior lecturer in the universitys Media School, was among a group of state legislators who visited the institute to investigate and found that there was no evidence to back up their fellow lawmakers concerns that children were being exploited.

Because the author requested a roll call vote, that locked it in, Pierce said in an interview on Friday. The amendment passed 53 to 34. Hard-core Republicans who actually believed this stuff voted for it, but others who were fearful of being taken out in a Republican primary went along with it, figuring, Im not going to lose my seat over this. Sweet, the bills author, is a freshman who toppled a longtime moderate Republican incumbent, Pierce pointed out.

When Kinseys report on womens sexuality came out in the 1950s, Pierce said, it showed that women were more sexually active than people believed, and there was an explosion of moral panic Youre lying. This cant be true.

The same moral panic, he said, has been happening in Indiana around transgender people. The governor last month signed into law a ban on gender-affirming care for minors. Kinseys research about the fluidity of gender may have alarmed many of those same lawmakers who approved the ban, Pierce said.

He told his colleagues during a heated floor debate that, even if they believed what was being said about Kinsey, it was 50 to 70 years ago, and that today, federal laws and university policies protect research subjects.

While the ban on using state funds will force the university to go through time-consuming checks to be sure public money isnt going toward institute costs, To me, the greater concern is the precedent that the legislator is attempting to stamp out a whole area of academic inquiry, Pierce said. What will be next?

In his opinion piece in The Washington Post, Garcia described the institute as the leading sex-research institute in the world, staffed by internationally renowned biologists, psychologists, anthropologists, health scientists, and demographers. The institute, he wrote, publishes dozens of scientific and academic articles each year across a variety of disciplines. Its critics, over the decades, have painted a far different picture, blaming the research center for promoting homosexuality and pornography, inciting the sexual revolution, and tearing away at the nations moral fabric.

Garcia warned that Indiana isnt alone in seeing debates over gender and sexuality become politicized. Legislators elsewhere, he wrote, are ignoring scientific evidence in passing laws that restrict reproductive health care, discussions of gender identity, and basic sex education. Despite the latest setback, he wrote, I am optimistic that this latest culture war will pass. And the Kinsey Institute will carry on.

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Indiana's Funding Ban for Kinsey Sex-Research Institute Threatens ... - The Chronicle of Higher Education

Diet and Dementia: Study Uncovers Gut-Brain Link to Alzheimer’s – Neuroscience News

Summary: A new study sheds light on the potential role of diet in preventing dementia. The analysis explored the relationship between gut health and Alzheimers disease, uncovering a strong link between specific types of gut bacteria and the likelihood of developing dementia.

The findings highlight the significance of gut microbiota in brain health and provide insights into the underlying mechanisms of Alzheimers disease.

This research opens up new avenues for personalized treatments and interventions that target gut health to potentially slow down or prevent the development of dementia.

Key Facts:

Source: University of Nevada Las Vegas

Could changing your diet play a role in slowing or even preventing the development of dementia? Were one step closer to finding out, thanks to a new UNLV study that bolsters the long-suspected link between gut health and Alzheimers disease.

The analysis led by a team of researchers with the Nevada Institute of Personalized Medicine (NIPM) at UNLV and published this spring in the Nature journalScientific Reports examined data from dozens of past studies into the belly-brain connection. The results? Theres a strong link between particular kinds of gut bacteria and Alzheimers disease.

Between 500 and 1,000 species of bacteria exist in the human gut at any one time, and the amount and diversity of these microorganisms can be influenced by genetics and diet.

The UNLV teams analysis found a significant correlation between 10 specific types of gut bacteria and the likelihood of developing Alzheimers disease. Six categories of bacteria Adlercreutzia, Eubacterium nodatum group, Eisenbergiella, Eubacterium fissicatena group, Gordonibacter,andPrevotella9 were identified as protective, and four types of bacteria Collinsella, Bacteroides, Lachnospira,andVeillonella were identified as a risk factor for Alzheimers disease.

Certain bacteria in humans guts can secrete acids and toxins that thin and seep through the intestinal lining, interact with theAPOE(a gene identified as a major risk factor for Alzheimers disease), and trigger a neuroinflammatory response affecting brain health and numerous immune functions, and potentially promoting development of the neurodegenerative disorder.

Researchers said their novel discovery of the distinct bacterial groups associated with Alzheimers disease provides new insights into the relationship between gut microbiota and the worlds most common form of dementia. The findings also advance scientists understanding of how an imbalance of that bacteria may play a role in the disorders development.

Most of the microorganisms in our intestines are considered good bacteria that promote health, but an imbalance of those bacteria can be toxic to a persons immune system and linked to various diseases, such as depression, heart disease, cancer, and Alzheimers disease, said UNLV research professorJingchun Chen.

The take-home message here is that your genes not only determine whether you have a risk for a disease, but they can also influence the abundance of bacteria in your gut.

While their analysis established overarching categories of bacteria typically associated with Alzheimers disease, the UNLV team said further research is needed to drill down into the specific bacterial species that influence risk or protection.

The hope is to one day develop treatments that are customized for an individual patient and their genetic makeup, such as medications or lifestyle change.

Studies have shown that changes in gut microbiome through probiotic use and dietary adjustments can positively impact the immune system, inflammation, and even brain function.

With more research it would be possible to identify a genetic trajectory that could point to a gut microbiome that would be more or less prone to developing diseases such as Alzheimers, said study lead author and UNLV graduate student Davis Cammann, but we also have to remember that the gut biome is influenced by many factors including lifestyle and diet.

Author: Keyonna SummersSource: University of Nevada Las VegasContact: Keyonna Summers University of Nevada Las VegasImage: The image is credited to Neuroscience News

Original Research: Open access.Genetic correlations between Alzheimers disease and gut microbiome genera by Jingchun Chen et al. Scientific Reports

Abstract

Genetic correlations between Alzheimers disease and gut microbiome genera

A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimers disease (AD) via neuroinflammatory processes across the microbiota-gut-brain axis.

The gut microbiota affects brain health through the secretion of toxins and short-chain fatty acids, which modulates gut permeability and numerous immune functions. Observational studies indicate that AD patients have reduced microbiome diversity, which could contribute to the pathogenesis of the disease.

Uncovering the genetic basis of microbial abundance and its effect on AD could suggest lifestyle changes that may reduce an individuals risk for the disease.

Using the largest genome-wide association study of gut microbiota genera from the MiBioGen consortium, we used polygenic risk score (PRS) analyses with the best-fit model implemented in PRSice-2 and determined the genetic correlation between 119 genera and AD in a discovery sample (ADc12 case/control: 1278/1293).

To confirm the results from the discovery sample, we next repeated the PRS analysis in a replication sample (GenADA case/control: 799/778) and then performed a meta-analysis with the PRS results from both samples.

Finally, we conducted a linear regression analysis to assess the correlation between the PRSs for the significant genera and theAPOEgenotypes. In the discovery sample, 20 gut microbiota genera were initially identified as genetically associated with AD case/control status.

Of these 20, three genera (Eubacterium fissicatenaas a protective factor, Collinsella,andVeillonellaas a risk factor) were independently significant in the replication sample. Meta-analysis with discovery and replication samples confirmed that ten genera had a significant correlation with AD, four of which were significantly associated with theAPOErs429358 risk allele in a direction consistent with their protective/risk designation in AD association.

Notably, the proinflammatory genusCollinsella,identified as a risk factor for AD, was positively correlated with theAPOErs429358 risk allele in both samples. Overall, the host genetic factors influencing the abundance of ten genera are significantly associated with AD, suggesting that these genera may serve as biomarkers and targets for AD treatment and intervention.

Our results highlight that proinflammatory gut microbiota might promote AD development through interaction withAPOE. Larger datasets and functional studies are required to understand their causal relationships.

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Diet and Dementia: Study Uncovers Gut-Brain Link to Alzheimer's - Neuroscience News

Shared Interests, Shared Essence: Unraveling the Psychology of Instant Connections – Neuroscience News

Summary: New research sheds light on the similarity-attraction effect, a psychological principle that governs how we form relationships based on shared interests.

The study highlight the critical role of self-essentialist reasoning, a belief system where individuals perceive an inherent essence as the driver of their preferences and dislikes.

Findings suggest individuals who subscribe to this reasoning are inclined to extrapolate shared worldviews from singular common interests. However, this approach may lead to unfounded assumptions, limiting the breadth of potential relationships due to minor disagreements or differences.

Key Facts:

Source: Boston University

Sometimes lifes most meaningful relationships grow from the briefest of connections. Like when you go to a party and meet someone wearing your favorite bands T-shirt, or who laughs at the same jokes as you, or who grabs that unpopular snack you alone (or so you thought) love. One small, shared interest sparks a conversationthats my favorite, too!and blossoms into lasting affection.

This is called the similarity-attraction effect: we generally like people who are like us. Now, new findings from a Boston University researcher have uncovered one reason why.

In a series of studies, Charles Chu,a BU Questrom School of Business assistant professor of management and organizations, tested the conditions that shape whether we feel attracted toor turned off byeach other. He found one crucial factor was what psychologists call self-essentialist reasoning, where people imagine they have some deep inner core or essence that shapes who they are.

Chu discovered that when someone believes an essence drives their interests, likes, and dislikes, they assume its the same for others, too; if they find someone with one matching interest, they reason that person will share their broader worldview.

The findingswere published in the American Psychological AssociationsJournal of Personality and Social Psychology.

If we had to come up with an image of our sense of self, it would be this nugget, an almost magical core inside that emanates out and causes what we can see and observe about people and ourselves, says Chu, who published the paper withBrian S. Lowery of Stanford Graduate School of Business.

We argue that believing people have an underlying essence allows us to assume or infer that when we see someone who shares a single characteristic, they must share my entire deeply rooted essence, as well.

But Chus research suggests this rush to embrace an indefinable, fundamental similarity with someone because of one or two shared interests may be based on flawed thinkingand that it could restrict who we find a connection with.

Working alongside the pull of the similarity-attraction effect is a countering push: we dislike those who we dont think are like us, often because of one small thingthey likethatpolitician, or band, or book, or TV show we loathe.

We are all so complex, says Chu. But we only have full insight into ourownthoughts and feelings, and the minds of others are often a mystery to us. What this work suggests is that we often fill in the blanks of others minds with our own sense of self and that can sometimes lead us into some unwarranted assumptions.

To examine why were attracted to some people and not to others, Chu set up four studies, each designed to tease out different aspects of how we make friendsor foes.

In the first study, participants were told about a fictional person, Jamie, who held either complementary or contradictory attitudes to them.

After asking participants their views on one of five topicsabortion, capital punishment, gun ownership, animal testing, and physician-assisted suicideChu asked how they felt about Jamie, who either agreed or disagreed with them on the target issue.

They were also quizzed about the roots of their identity to measure their affinity with self-essentialist reasoning.

Chu found the more a participant believed their view of the world was shaped by an essential core, the more they felt connected to Jamie who shared their views on one issue.

In a second study, he looked at whether that effect persisted when the target topics were less substantive. Rather than digging into whether people agreed with Jamie on something as divisive as abortion, Chu asked participants to estimate the number of blue dots on a page, then categorized themand the fictional Jamieas over- or under-estimators.

Even with this slim connection, the findings held: the more someone believed in an essential core, the closer they felt to Jamie as a fellow over- or under-estimator.

I found that both with pretty meaningful dimensions of similarity as well as with arbitrary, minimal similarities, people who are higher in their belief that they have an essence are more likely to be attracted to these similar others as opposed to dissimilar others, says Chu.

In two companion studies, Chu began disrupting this process of attraction, stripping out the influence of self-essentialist reasoning. In one experiment, he labeled attributes (such as liking a certain painting) as either essential or nonessential; in another, he told participants that using their essence to judge someone else could lead to an inaccurate assessment of others.

It breaks this essentialist reasoning process, it cuts off peoples ability to assume that what theyre seeing is reflective of a deeper similarity, says Chu.

One way I did that was to remind people that this dimension of similarity is actually not connected or related to your essence at all; the other way was by telling people that using their essence as a way to understand other people is not very effective.

Chu says theres a key tension in his findings that shape their application in the real world. On the one hand, were all searching for our communityits fun to hang out with people who share our hobbies and interests, love the same music and books as us, dont disagree with us on politics.

This type of thinking is a really useful, heuristic psychological strategy, says Chu. It allows people to see more of themselves in new people and strangers.

But it also excludes people, sets up divisions and boundariessometimes on the flimsiest of grounds.

When you hear a single fact or opinion being expressed that you either agree or disagree with, it really warrants taking an additional breath and just slowing down, he says.

Not necessarily taking that single piece of information and extrapolating on it, using this type of thinking to go to the very end, that this person is fundamentally good and like me or fundamentally bad and not like me.

Chu, whose background mixes the study of organizational behavior and psychology, teaches classes on negotiation at Questrom and says his research has plenty of implications in the business world, particularly when it comes to making deals.

I define negotiations as conversations, and agreements and disagreements, about how power and resources should be distributed between people, he says.

What inferences do we make about the other people were having these conversations with? How do we experience and think about agreement versus disagreement? How do we interpret when someone gets more and someone else gets less? These are all really central questions to the process of negotiation.

But in a time when political division has invaded just about every sphere of our lives,including workplaces, the applications of Chus findings go way beyond corporate horse trading.

Managing staff, collaborating on projects, team bondingall are shaped by the judgments we make about each other. Self-essentialist reasoning may even influence societys distribution of resources, says Chu: who we consider worthy of support, who gets funds and who doesnt, could be driven by this belief that peoples outcomes are caused by something deep inside of them.

Thats why he advocates pushing pause before judging someone who, at first blush, doesnt seem like you.

There are ways for us to go through life and meet other people, and form impressions of other people, without constantly referencing ourselves, he says.

If were constantly going around trying to figure out,whos like me, whos not like me?,thats not always the most productive way of trying to form impressions of other people. People are a lot more complex than we give them credit for.

Author: Katherine GianniSource: Boston UniversityContact: Katherine Gianni Boston UniversityImage: The image is credited to Neuroscience News

Original Research: Closed access.Self-Essentialist Reasoning Underlies the Similarity-Attraction Effect by Charles Chu et al. Journal of Personality and Social Psychology

Abstract

Self-Essentialist Reasoning Underlies the Similarity-Attraction Effect

We propose that self-essentialist reasoning is a foundational mechanism of the similarity-attraction effect.

Our argument is that similarity breeds attraction in two steps: (a) people categorize someone with a shared attribute as a person like me based on the self-essentialist belief that ones attributes are caused by an underlying essence and (b) then apply their essence (and the other attributes it causes) to the similar individual to infer agreement about the world in general (i.e., a generalized shared reality).

We tested this model in four experimental studies (N = 2,290) using both individual difference and moderation-of-process approaches.

We found that individual differences in self-essentialist beliefs amplified the effect of similarity on perceived generalized shared reality and attraction across both meaningful (Study 1) and minimal (Study 2) dimensions of similarity.

We next found that manipulating (i.e., interrupting) the two crucial steps of the self-essentialist reasoning processthat is, by severing the connection between a similar attribute and ones essence (Study 3) and deterring people from applying their essence to form an impression of a similar other (Study 4)attenuated the effect of similarity on attraction.

We discuss the implications for research on the self, similarity-attraction, and intergroup phenomena.

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Shared Interests, Shared Essence: Unraveling the Psychology of Instant Connections - Neuroscience News

YouTube Habits Linked to Increased Loneliness and Anxiety – Neuroscience News

Summary: Researchers have found a link between frequent YouTube usage and increased levels of loneliness, anxiety, and depression, especially among viewers under 29.

The study raises concerns about parasocial relationships between creators and viewers, as well as the algorithmic recommendation of suicide-related content. The team suggests AI-based solutions to guide users towards positive mental health content.

Key Facts:

Source: Griffith University

Frequent users of YouTube have higher levels of loneliness, anxiety, and depression according to researchers from the Australian Institute for Suicide Research and Prevention (AISRAP).

Dr Luke Balcombe and Emeritus Professor Diego De Leo from Griffith Universitys School of Applied Psychology and AISRAP sought to understand both the positive and negative impacts of the worlds most used streaming platform on mental health.

They found the most negatively affected individuals were those under 29 years of age, or who regularly watched content about other peoples lives.

Lead author Dr Luke Balcombe said the development of parasocial relationships between content creators and followers could be cause for concern, however some neutral or positive instances of creators developing closer relationships with their followers also occurred.

These online relationships can fill a gap for people who, for example, have social anxiety, however it can exacerbate their issues when they dont engage in face-to-face interactions, which are especially important in developmental years, he said.

We recommend individuals limit their time on YouTube and seek out other forms of social interaction to combat loneliness and promote positive mental health.

Dr Balcombe said the amount of time spent on YouTube was often a concern for parents, who struggled to monitor their childrens use of the platform for educational or other purposes.

For the purpose of the study, over two hours per day of YouTube consumption was classed as high frequency use and over five hours a day as saturated use.

The study also determined more needed to be done to prevent suicide-related content being recommended to users based on algorithms for suggested viewing.

While ideally, people shouldnt be able to search for these topics and be exposed to methods, the YouTube algorithm does push recommendations or suggestions based on previous searches, which can send users further down a disturbing rabbit hole.

Users can report this type of content, but sometimes it may not be reported, or it could be there for a few days or weeks and with the sheer volume of content passing through, its almost impossible for YouTubes algorithms to stop all of it.

If a piece of content is flagged as possibly containing suicide or self-harm topics, YouTube then provides a warning and asks the user if they want to play the video.

With vulnerable children and adolescents who engage in high frequency use, there could be value in monitoring and intervention through artificial intelligence, Dr Balcombe said.

Weve explored humancomputer interaction issues and proposed a concept for an independent-of-YouTube algorithmic recommendation system which will steer users toward verified positive mental health content or promotions.

YouTube is increasingly used for mental health purposes, mainly for information seeking or sharing and many digital mental health approaches are being tried with varying levels of merit, but with over 10,000 mental health apps currently available, it can be really overwhelming knowing which ones to use, or even which ones to recommend from a practitioner point of view.

There is a gap for verified mental health or suicide tools based on a mix of AI-based machine learning, risk modeling and suitably qualified human decisions, but by getting mental health and suicide experts together to verify information from AI, digital mental health interventions could be a very promising solution to support increasing unmet mental health needs.

Author: Christine BowleySource: Griffith UniversityContact: Christine Bowley Griffith UniversityImage: The image is credited to Neuroscience News

Original Research: Open access.The Impact of YouTube on Loneliness and Mental Health by Luke Balcombe et al. Informatics

Abstract

The Impact of YouTube on Loneliness and Mental Health

There are positives and negatives of using YouTube in terms of loneliness and mental health. YouTubes streaming content is an amazing resource, however, there may be bias or errors in its recommendation algorithms.

Parasocial relationships can also complicate the impact of YouTube use. Intervention may be necessary when problematic and risky content is associated with unhealthy behaviors and negative impacts on mental health. Children and adolescents are particularly vulnerable.

Although YouTube might assist in connecting with peers, there are privacy, safety, and quality issues to consider.

This paper is an integrative review of the positive and negative impacts of YouTube with the aim to inform the design and development of a technology-based intervention to improve mental health. The impact of YouTube use on loneliness and mental health was explored by synthesizing a purposive selection (n= 32) of the empirical and theoretical literature.

Next, we explored humancomputer interaction issues and proposed a concept whereby an independent-of-YouTube algorithmic recommendation system steers users toward verified positive mental health content or promotions.

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YouTube Habits Linked to Increased Loneliness and Anxiety - Neuroscience News

Human Brain Organoids Reveal How Microglia Develop and Function – Neuroscience News

Summary: Researchers have developed human brain organoids that contain microglia, the immune cells of the brain. These organoids allow researchers to study how microglia develop and function in a more realistic setting than previous models.

The researchers found that microglia are influenced by the environment in which they develop and that they play a role in both development and disease. Their findings could lead to new treatments for neurological disorders.

Key Facts:

Source: Salk Institute

Situated at the intersection of the human immune system and the brain are microglia, specialized brain immune cells that play a crucial role in development and disease. Although the importance of microglia is undisputed, modeling and studying them has remained a difficult task.

Unlike some human cells that can be studied outside of the body or in nonhuman models, human microglia are difficult to study when removed from the human-brain-like environment.

To overcome this barrier, Salk scientists developed an organoid modela three-dimensional collection of cells that mimics features of human tissues. This model allows researchers to study human microglial development and function for the first time in living human-derived tissue.

Further, the scientists examined patient-derived microglia from children with macrocephalic autism spectrum disorder (a condition where infant head circumference is greater than 97 percent of other infants) to determine whether brain environment influences the development of more reactive microglia.

The findings, published inCellon May 11, 2023, highlight the importance of immune cell and brain interaction, and improve the understanding of neurodegenerative and developmental diseases, such as autism spectrum disorder and Alzheimers disease.

Outside of the brain environment, microglia lose almost all function and meaning, says ProfessorRusty Gage, senior author and holder of the Vi and John Alder Chair for Research on Age-Related Neurodegenerative Disease.

We knew that if we found a way to replicate the human brain environment in an organoid in order to study human microglia, then we would finally have a tool for examining how the heathy and diseased brain influence microglia and, reciprocally, how healthy and diseased microglia influence the brain.

Emerging roughly 10 years ago, organoids have become a prevalent tool to bridge the gap between cell and human studies. Organoids can mimic human development and organ generation better than other laboratory systems, allowing researchers to study how drugs or diseases affect human cells in a more realistic setting.

Brain organoids are typically grown in culture dishes, but the organoids are structurally and functionally limited by the lack of blood vessels, short survival time, and inability to sustain diverse cell types (like microglia).

To createabrainorganoid model thatcontainsmature microgliaand enables us to research them, we used a noveltransplantationtechnique to create a human-brain-like environment says co-first author Abed Mansour, aformerpostdoctoral researcher in Gages lab and now an assistant professor at the Hebrew University of Jerusalem.

So we could finally make a human brain organoid that had all the features necessary to orchestrate human microglia growth, behavior, and function.

Unlike previous models, the researchers created a human brain organoid that had microgliaanda human-brain-like environment, which finally allowed them to look at environmental influences on microglia throughout brain development.

They found that a characteristic protein called SALL1 appeared as early as eleven weeks into development and served to confirm microglial identity and promote mature function. Additionally, they found that brain environment-specific factors, like the proteins TMEM119 and P2RY12, were necessary for microglia to function.

Creating a human brain model that can effectively replicate the human brain environment is very exciting, says Associate ProfessorAxel Nimmerjahn, another author of the study.

With this model, we can finally investigate how human microglia function within the human brain environment.

As the team learned more about microglia, the importance of the relationship between brain environment and microglia became clearespecially in disease scenarios.

The labpreviously examinedneurons derived from people with autism spectrum disorder and found their neurons grew faster and had more complex branches than neurotypical counterparts.

With the new organoid model, the team could ask whether those neuronal differences altered the brain environment and influenced microglia development.

To do so, they compared microglia derived from skin samples from three individuals with macrocephalic autism spectrum disorder versus three neurotypical individuals with macrocephaly.

The researchers found that individuals with autism spectrum disorder exhibited the neuronal differences the team had previously noted, and that the microglia were influenced by those differences in their growth environment.

Because of this neuron-dependent environmental change, the microglia became more reactive to damage or intrudersa finding that may explain the brain inflammation observed in some individuals with autism spectrum disorder.

Since this was a preliminary study with a small sample size, the team plans to examine more microglia from additional people in the future to verify their findings. They also aim to expand their research to study other developmental and neurodegenerative diseases to see how microglia are contributing to disease onset.

Rather than deconstruct the brain, we decided to construct it ourselves, says co-first author Simon Schafer, a former postdoctoral researcher in Gages lab and now an assistant professor at Technical University of Munich.

By building our own brain model we can work from the bottom up and see solutions that may be impossible to see from the top down. We are eager to continue improving on our model and unravelling the relationship between the brain and immune system.

Other authors include Monique Pena, Saeed Ghassemzadeh, Lisa Mitchell, Amanda Mar, Daphne Quang, Sarah Stumpf, and Clara Baek of the Salk Institute; Johannes C. M. Schlachetzki, Addison J. Lana, and Christopher K. Glass of UC San Diego; Irene Santisteban of the Technical University of Munich; and Raghad Zaghal of the Hebrew University of Jerusalem.

Funding: The work was supported by the National Institutes of Health (R01 AG056306, R01 AG057706, R01 AG056511, R01 AG061060, R01 NS108034, U19 NS123719, NCI CCSG: P30 014195, NCI CCSG: P30 014195), the American Heart Association and Paul G. Allen Frontiers Group (grant 19PABHI34610000), the Brain and Behavior Research Foundation (27685 and 30421), the German Research Foundation (500300695), the Milky Way Research Foundation, Annette C. Merle-Smith and the Robert and Mary Jane Engman Foundation, the European Molecular Biology Organization (ALTF 1214-2014), the Human Frontier Science Program (LT001074/2015), the European Research Council, the Chapman Foundation, the JBP Foundation and the Helmsley Charitable Trust.

Author: Salk CommunicationsSource: Salk InstituteContact: Salk Communications Salk InstituteImage: The image is credited to Neuroscience News

Original Research: Open access.An in vivo neuroimmune organoid model to study human microglia phenotypes by Rusty Gage et al. Cell

Abstract

An in vivo neuroimmune organoid model to study human microglia phenotypes

Microglia are specialized brain-resident macrophages that play crucial roles in brain development, homeostasis, and disease. However, until now, the ability to model interactions between the human brain environment and microglia has been severely limited.

To overcome these limitations, we developed aninvivoxenotransplantation approach that allows us to study functionally mature human microglia (hMGs) that operate within a physiologically relevant, vascularized immunocompetent human brain organoid (iHBO) model.

Our data show that organoid-resident hMGs gain human-specific transcriptomic signatures that closely resemble theirinvivocounterparts.Invivotwo-photon imaging reveals that hMGs actively engage in surveilling the human brain environment, react to local injuries, and respond to systemic inflammatory cues.

Finally, we demonstrate that the transplanted iHBOs developed here offer the unprecedented opportunity to study functional human microglia phenotypes in health and disease and provide experimental evidence for a brain-environment-induced immune response in a patient-specific model of autism with macrocephaly.

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Human Brain Organoids Reveal How Microglia Develop and Function - Neuroscience News