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UCLA to turn former Westside Pavilion into centers for research on immunology and quantum science - KABC-TV
Funding allows advancement of diverse programs through multiple clinical data readouts, including multiple indications for lead candidatefelzartamab
SOUTH SAN FRANCISCO, Calif., Jan. 4, 2024 /PRNewswire/ --Human Immunology Biosciences (HI-Bio), a clinical-stage biotechnology company developing targeted therapies for patients withsevere immune-mediated diseases (IMDs), today announced the closing of a $95 million Series B financing led by new investor Alpha Wave Global. Viking Global Investors and Arkin Bio Capital participated in the financing, as well as existing investors Jeito Capital and ARCH Venture Partners.
"These funds allow us to advancefelzartamab, our clinically differentiated lead therapeutic candidate, through clinical readouts in multiple indications and preparation for registrational studies," said Travis Murdoch, M.D., CEO of HI-Bio. "We are encouraged by promising clinical data to date for felzartamab and its anti-CD38 cell depletion approach, and we look forward to new data, including Phase 2 results from an investigator-initiated trial for antibody-mediated rejection in kidney transplant patients."
Since the company's launch, HI-Bio has advancedfelzartamab, a monoclonal antibody targeting CD38 and in-licensed from MorphoSys, across indications including antibody-mediated rejection (AMR), IgA nephropathy (IgAN), lupus nephritis (LN) and primary membranous nephropathy (PMN). Felzartamab has received Breakthrough Therapy Designation and Orphan Drug Designation from the U.S. Food and Drug Administration in PMN. HI-Bio has also initiated a clinical study of HIB210, an anti-C5aR1 candidate targeting neutrophil activation and chemotaxis.
"Immune-mediated diseases contribute to an immense disease burden which drives the need for novel targeted treatments to improve on existing therapies," said Chris Dimitropoulos, Managing Director of Healthcare Investments at Alpha Wave Global. "HI-Bio is generating compelling clinical data demonstrating the differentiated potential of felzartamab; we look forward to continued progress for felzartamab across multiple indications with high unmet need."
Funding from the Series B will be used to advance clinical development offelzartamab, to evaluate the clinical properties of HIB210 in healthy volunteers and to advance a discovery-stage program targeting mast cell dysfunction toward IND-enabling studies. In conjunction with the financing, the company announced that Chris Dimitropoulos, Managing Director of Healthcare Investments at Alpha Wave Global, has been appointed to the HI-Bio Board of Directors.
About HI-Bio Human Immunology Biosciences, Inc. (HI-Bio) is a clinical-stage biotechnology companyfocused on discovering and developing precision medicines for people suffering from immune-mediated diseases (IMDs). HI-Bio is leading clinical immunology into its next chapter by targeting cellular drivers of disease. To learn more about HI-Bio, visit us at http://www.hibio.com or follow us on LinkedIn and Twitter.
SOURCE HI-Bio
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HI-Bio Announces $95 Million Series B Financing to Advance Targeted Therapies for Immune-Mediated Diseases - PR Newswire
This webinar will be hosted live and available on-demand
Thursday, January 25, 2024 2:30-4:00 PM Eastern Time
B cells are the classical shield bearers of immune system memory, but memory T cell phenotypes also exist, playing crucial roles in controlling viral infections and modulating immune responses.
In this webinar brought to you by The Scientists Creative Services Team, Grgoire Lauvau and Marcus Buggert will explain what memory T cells are, how they differ from cytotoxic T cells, and their function in human tissues during physiological and pathological situations.
Topics to be covered
Grgoire Lauvau, PhD Professor The Sylvia and Robest Olnick Faculty Scholar in Cancer Research Albert Einstein College of Medicine Department of Microbiology and Immunology
Marcus Buggert, PhD Assistant Professor Karolinska Institutet Department of Medicine Huddinge Center for Infectious Medicine (CIM)
See the article here:
Beyond Cytotoxicity: The Importance of T Cell Memory - The Scientist
In a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia have cracked the code behind IKAROS, an essential protein for immune cell development and protection against pathogens and cancer.
This disruptive research, led by the eminent Professor Nicholas Huntington of Monash University's Biomedicine Discovery Institute, is poised to reshape our comprehension of gene control networks and its impact on everything from eye colour to cancer susceptibility and design of novel therapies.
The study, published in Nature Immunology, promises pivotal insights into the mechanisms safeguarding us against infections and cancers. When the transcription factor Ikaros/Ikzf1 was deliberately obstructed, be it in preclinical models or humans, the once-mighty activity of Natural Killer (NK) cells, our immune system's frontline warriors, plummeted. Loss of this transcription factor in NK cells resulted in wide-spread dysregulation of NK cell development and function, preventing their ability to recognize and kill virus-infected cells and clear metastatic tumour cells from circulation. Aiolos/Ikzf3 and Helios/Ikzf2, related family member were found to partial compensate for the loss of Ikaros, as such when multiple IKZF-family members were inhibited, NK cells underwent rapidly death. Mechanistically, Aiolos and Ikaros were found to directly bind and activate most members of the JUN/FOS family, transcription factors known for their essential roles in human embryo development and tissue function.
This discovery opens the door to the prospect of potential novel cancer therapeutics. NK cells, our first line of defence against pathogens and internal threats like cancers, could be fortified by therapies enhancing their killing prowess by targeting IKAROS and JUN/FOS biology.
Professor Huntington notes that drugs targeting IKAROS/AIOLOS have already received approval from the US Food and Drug Administration (FDA) and local Therapeutic Goods Administration (TGA) for the treatment of B cell malignancy "but until now we haven't understood how these drugs work, armed with this new information it could be possible to develop novel drugs targeting these complexes which may offer differentiated pharmacology and therapeutic index for treating disease," he said.
Importantly on this front, Professor Huntington's team were able to show that IKAROS had a conserved role in healthy B cells and thus potentially B cell cancers.
Source:
Journal reference:
Goh, W., et al. (2024). IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature Immunology. doi.org/10.1038/s41590-023-01718-4.
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IKAROS: Unlocking the secrets of the immune system's key player - News-Medical.Net
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UCLA to turn former shopping mall into centers for research on immunology and quantum science - The Caledonian-Record
While teaching a field lab for a class of ecology students in the woods behind the Merrimack campus, I was telling them that if you flip over logs and rocks, sometimes you can find snakes, salamanders, and other interesting animals.
As I stooped down and turned over a small log, I was promptly stung on my finger by a centipede. The pain was pretty intense, like that of a bee sting, and the next thing the students heard me say was [bleep]! I looked up to see 15 shocked, wide-eyed students staring at me. Embarrassed by my involuntary outburst of profanity, I quickly apologized to the group of stunned students, who laughed when they realized what had happened.
For one of our lab exercises, we waded into a small man-made pond behind the science building at Merrimack to catch crawfish and goldfish and do population estimates. I put on my rubber chest waders and told my students they had to enter the water carefully because the plastic lining on the bottom of the pond was very slippery. I sat down at the edge of the pond, lowered my legs into the water, and as soon as I stood up, I slipped and fell in. In addition to being embarrassed, I had to walk around in cold wet clothes for the remainder of the day.
While co-leading a college biology trip to the Galapagos Islands, I was snorkeling with several students. I was floating at the surface a few feet from the rocky shoreline and decided to take a photo of a small, bright orange anemone that was attached to an underwater rock. I took several photos and when I was through, the students swam over to me and excitedly asked if I had seen the giant manta ray.
What manta ray? I asked.
It was about 10 feet wide, one of the students told me. It swam right behind you!
Manta rays are the largest rays in the world, and one of the species I had hoped to see on our trip. Apparently, it swam within a few feet of me, and I missed it because I was preoccupied with photographing an anemone? Arrrggghhh!
On a college biology trip to Australia, after a 20-hour-plus flight, we landed at the Cairns Airport in Queensland at around 2 in the morning. Half asleep, we all had to go through customs before heading to our hotel. The two head professors were leading the group at the front of the line, so I decided Id take up the rear to make sure everyone got through OK.
The last student in line was an affable young man named Lou. The customs agent asked Lou to open his duffle bag, and then began to ask him some questions.
You did fill out the customs declaration form on the plane, didnt you?
Yes, I did, Lou replied.
And you read it carefully?
Yes, I did, said Lou.
And you do know youre not supposed to bring any meat or agricultural products into the country, right?
At this point I thought, uh-oh, somethings wrong.
The customs agent reached into Lous duffle bag and pulled out a plastic bag that contained about half a pound of pork fat.
Whats this, mate? asked the customs agent.
Its pork fat, sir, Lou replied. I brought it to use for fishing bait.
Fishing bait? I interjected.
Ya, Lou responded. I didnt know if Id be able to get any bait down here, and I wanted to go fishing.
Lou, I said, First of all, Australia is surrounded by ocean. Its a gigantic island. Im sure theyve got fishing bait. Secondly, I dont think any self-respecting fish would even eat pork fat!
The customs agent just smiled, gave Lou a warning, and confiscated his fishing bait.
On the Belize trip I mentioned earlier, a group of us were standing outside the general store in a village. Tropical developing countries always seem to have mangy stray dogs hanging around human settlements, and Belize was no exception.
A group of three or four skinny, sickly-looking dogs were milling around near the general store. Im always afraid of stray dogs because they could carry diseases, including rabies. Suddenly the dogs started to fight with each other, and the snarling, snapping pack rapidly moved toward us. Instinctively, I grabbed the person closest to me who happened to be one of our students and put her in front of me as protection. She screamed and said, What are you doing?
Thankfully, no one was bitten.
I still get teased about that one.
Don Lyman can be reached at donlymannature@gmail.com.
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Some wild misadventures of a college biology instructor - The Boston Globe
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Kuru Disease: Bridging the Gap Between Prion Biology and Human Health - Cureus