Free Fatty Acid Suppression Linked to Insulin Sensitivity in PCOS Endocrinology Advisor
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Free Fatty Acid Suppression Linked to Insulin Sensitivity in PCOS - Endocrinology Advisor
Free Fatty Acid Suppression Linked to Insulin Sensitivity in PCOS Endocrinology Advisor
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Free Fatty Acid Suppression Linked to Insulin Sensitivity in PCOS - Endocrinology Advisor
image:
A myelinating oligodendrocyte(green)
Credit: Peggy Assinck, Altos Labs-Cambridge Institute of Science
Researchers report February 15 in the journal Cell that ancient viruses may be to thank for myelinand, by extension, our large, complex brains. The team found that a retrovirus-derived genetic element or retrotransposon is essential for myelin production in mammals, amphibians, and fish. The gene sequence, which they dubbed RetroMyelin, is likely a result of ancient viral infection, and comparisons of RetroMyelin in mammals, amphibians, and fish suggest that retroviral infection and genome-invasion events occurred separately in each of these groups.
Retroviruses were required for vertebrate evolution to take off, says senior author and neuroscientist Robin Franklin of Altos Labs-Cambridge Institute of Science. If we didnt have retroviruses sticking their sequences into the vertebrate genome, then myelination wouldnt have happened, and without myelination, the whole diversity of vertebrates as we know it would never have happened.
Myelin is a complex, fatty tissue that ensheathes vertebrate nerve axons. It enables rapid impulse conduction without needing to increase axonal diameter, which means nerves can be packed closer together. It also provides metabolic support to nerves, which means nerves can be longer. Myelin first appeared in the tree of life around the same time as jaws, and its importance in vertebrate evolution has long been recognized, but until now, it was unclear what molecular mechanisms triggered its appearance.
The researchers noticed RetroMyelins role in myelin production when they were examining the gene networks utilized by oligodendrocytes, the cells that produce myelin in the central nervous system. Specifically, the team was investigating the role of noncoding regions including retrotransposons in these gene networkssomething that hasnt previously been explored in the context of myelin biology.
Retrotransposons compose about 40% of our genomes, but nothing is known about how they might have helped animals acquire specific characteristics during evolution, says first author Tanay Ghosh, a computational biologist at Altos Labs-Cambridge Institute of Science. Our motivation was to know how these molecules are helping evolutionary processes, specifically in the context of myelination.
In rodents, the researchers found that the RNA transcript of RetroMyelin regulates the expression of myelin basic protein, one of the key components of myelin. When they experimentally inhibited RetroMyelin in oligodendrocytes and oligodendrocyte progenitor cells (the stem cells from which oligodendrocytes are derived), the cells could no longer produce myelin basic protein.
To examine whether RetroMyelin is present in other vertebrate species, the team searched for similar sequences within the genomes of jawed vertebrates, jawless vertebrates, and several invertebrate species. They identified analogous sequences in all other classes of jawed vertebrates (birds, fish, reptiles, and amphibians) but did not find a similar sequence in jawless vertebrates or invertebrates.
Theres been an evolutionary drive to make impulse conduction of our axons quicker because having quicker impulse conduction means you can catch things or flee from things more rapidly, says Franklin.
Next, the researchers wanted to know whether RetroMyelin was incorporated once into the ancestor of all jawed vertebrates or whether there were separate retroviral invasions in the different branches. To answer these questions, they constructed a phylogenetic tree from 22 jawed vertebrate species and compared their RetroMyelin sequences. The analysis revealed that RetroMyelin sequences were more similar within than between species, which suggests that RetroMyelin was acquired multiple times through the process of convergent evolution.
The team also showed that RetroMyelin plays a functional role in myelination in fish and amphibians. When they experimentally disrupted the RetroMyelin gene sequence in the fertilized eggs of zebrafish and frogs, they found that the developing fish and tadpoles produced significantly less myelin than usual.
The study highlights the importance of non-coding regions of the genome for physiology and evolution, the researchers say. Our findings open up a new avenue of research to explore how retroviruses are more generally involved in directing evolution, says Ghosh.
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This research was supported by the Adelson Medical Research Foundation, the UK Multiple Sclerosis Society, the Wellcome Trust, and the Altos Labs-Cambridge Institute of Science.
Cell, Ghosh et al., A retroviral link to vertebrate myelination through retrotransposon RNA mediated control of myelin gene expression https://cell.com/cell/fulltext/S0092-8674(24)00013-8
Cell (@CellCellPress), the flagship journal of Cell Press, is a bimonthly journal that publishes findings of unusual significance in any area of experimental biology, including but not limited to cell biology; molecular biology; neuroscience; immunology; virology and microbiology; cancer; human genetics; systems biology; signaling; and disease mechanisms and therapeutics. Visit http://www.cell.com/cell. To receive Cell Press media alerts, contact press@cell.com.
Experimental study
Animals
A retroviral link to vertebrate myelination through retrotransposon RNA-mediated control of myelin gene expression
15-Feb-2024
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Ancient retroviruses played a key role in the evolution of vertebrate brains - EurekAlert
An Omaha doctor who served in the battlefield is now helping patients battle anxiety and depression. Dr Leslie Koenig opened Waybridge Clinic in October. The people who walk in there are not the people we see three weeks later. Theyre entirely different smiling and laughing, said Koenig, an emergency medicine physician. Koenig is a U.S. military veteran who served as a Navy doctor in Afghanistan where she used ketamine as a sedative to treat people on the battlefield. Later, in emergency rooms, she encountered mental health crises, daily.If someone is suicidal, a panic attack, where do they go: the emergency room. That was me, said Koenig.With additional training, shes now administering low dose Ketamine infusions to treat people with medication resistant anxiety, depression, chronic pain, PTSD and OCD. Each patients vital signs are monitored during the intravenous infusion and they must continue seeing their therapist and family practice doctor. Koenig is also a meditation coach and takes a holistic approach to health, encouraging people to continue seeing their therapist, eating healthy food and taking part in exercise.The clinic is located in west Omaha: Waybridge Clinic.I liken it to a gym session. You come here and do some serious work, but then you have to go and support that gym session after. You need sleep and you need the nutrition, she said. Low dose Ketamine infusions are considered an off-label use for mental health. A handful of clinics in the Omaha area offer the treatments.There are so many medications used off label. Its totally safe. Ketamine is an old medication with a new purpose. When it was first FDA approved, it was for anesthesia and what were finding out is that in low doses, it has neuroplastic benefits where you can grow new brain connections, said Koenig. With new connections, Koenig said perspective changes. "You can change your thinking," she said. She said Ketamine works on different receptors in the brain than traditional meds which are used to treat anxiety and depression. She said the new connections created by Ketamine help the brain bypass prior triggers to mental health issues, so that they no longer impact an individual. Jay Allen visited Koenig recently to talk about his life-changing recovery. He jokingly told her his face now hurts from smiling so much.I missed feeling happy. I missed laughing with my friends. I missed the positive person I used to be, said Allen, who recalls that he started feeling better after the second treatment.Allen is a military veteran and mechanical engineer who said hes excited to live again, instead of just existing from day to day. Now I can look forward and see hope, said Allen.His positive recovery and story is repeated by Jack Christian, a husband and father of three who loves creating music with his two local bands.He believes his life-long anxiety was rooted in childhood.I pretty much exhausted all my options, said Christian, who tried many prescription medications over the years and nothing seemed to pull him out of the funk.Hes had 7 low dose Ketamine treatments and after the baseline 6 treatments, some patients never need another dose. Some have an occasional booster dose. To me, its ground-breaking. Its been a godsend for me, said Christian, who now journals and practices yoga. Patients describe the infusion itself as calming and they find themselves in a place between wakefulness and sleep as the drug helps them sort through issues in their mind.Youre conscious, but youre watching your subconscious open up to you like a movie, said Christian. Allen describes the infusion as surreal.I liken it to being in a rowboat in the ocean. You can change the direction but at the end of the day, youre at the mercy of the medicine, said Allen.Both said they noticed positive changes days and weeks after the infusion and the changes are lasting. Koenig is working on trying to get health insurance companies to pay for the treatments and shes considering options for employers and non-profits to chip in. Right now, infusions are $500 a treatment, with a baseline program of 6 infusions, or $3,000.We need to destigmatize this and really make lasting change happen, said Koenig. Allen said hes forever grateful that his mom found the clinic and got him in for a consult.Im excited for whats next and I cant thank you guys enough for that, he said, hugging Koenig in her office lobby. Click here for the latest headlines from KETV NewsWatch 7
An Omaha doctor who served in the battlefield is now helping patients battle anxiety and depression. Dr Leslie Koenig opened Waybridge Clinic in October.
The people who walk in there are not the people we see three weeks later. Theyre entirely different smiling and laughing, said Koenig, an emergency medicine physician.
Koenig is a U.S. military veteran who served as a Navy doctor in Afghanistan where she used ketamine as a sedative to treat people on the battlefield. Later, in emergency rooms, she encountered mental health crises, daily.
If someone is suicidal, a panic attack, where do they go: the emergency room. That was me, said Koenig.
With additional training, shes now administering low dose Ketamine infusions to treat people with medication resistant anxiety, depression, chronic pain, PTSD and OCD. Each patients vital signs are monitored during the intravenous infusion and they must continue seeing their therapist and family practice doctor.
Koenig is also a meditation coach and takes a holistic approach to health, encouraging people to continue seeing their therapist, eating healthy food and taking part in exercise.
The clinic is located in west Omaha: Waybridge Clinic.
I liken it to a gym session. You come here and do some serious work, but then you have to go and support that gym session after. You need sleep and you need the nutrition, she said.
Low dose Ketamine infusions are considered an off-label use for mental health. A handful of clinics in the Omaha area offer the treatments.
There are so many medications used off label. Its totally safe. Ketamine is an old medication with a new purpose. When it was first FDA approved, it was for anesthesia and what were finding out is that in low doses, it has neuroplastic benefits where you can grow new brain connections, said Koenig.
With new connections, Koenig said perspective changes. "You can change your thinking," she said.
She said Ketamine works on different receptors in the brain than traditional meds which are used to treat anxiety and depression. She said the new connections created by Ketamine help the brain bypass prior triggers to mental health issues, so that they no longer impact an individual.
Jay Allen visited Koenig recently to talk about his life-changing recovery. He jokingly told her his face now hurts from smiling so much.
I missed feeling happy. I missed laughing with my friends. I missed the positive person I used to be, said Allen, who recalls that he started feeling better after the second treatment.
Allen is a military veteran and mechanical engineer who said hes excited to live again, instead of just existing from day to day.
Now I can look forward and see hope, said Allen.
His positive recovery and story is repeated by Jack Christian, a husband and father of three who loves creating music with his two local bands.
He believes his life-long anxiety was rooted in childhood.
I pretty much exhausted all my options, said Christian, who tried many prescription medications over the years and nothing seemed to pull him out of the funk.
Hes had 7 low dose Ketamine treatments and after the baseline 6 treatments, some patients never need another dose. Some have an occasional booster dose.
To me, its ground-breaking. Its been a godsend for me, said Christian, who now journals and practices yoga.
Patients describe the infusion itself as calming and they find themselves in a place between wakefulness and sleep as the drug helps them sort through issues in their mind.
Youre conscious, but youre watching your subconscious open up to you like a movie, said Christian.
Allen describes the infusion as surreal.
I liken it to being in a rowboat in the ocean. You can change the direction but at the end of the day, youre at the mercy of the medicine, said Allen.
Both said they noticed positive changes days and weeks after the infusion and the changes are lasting.
Koenig is working on trying to get health insurance companies to pay for the treatments and shes considering options for employers and non-profits to chip in. Right now, infusions are $500 a treatment, with a baseline program of 6 infusions, or $3,000.
We need to destigmatize this and really make lasting change happen, said Koenig.
Allen said hes forever grateful that his mom found the clinic and got him in for a consult.
Im excited for whats next and I cant thank you guys enough for that, he said, hugging Koenig in her office lobby.
Click here for the latest headlines from KETV NewsWatch 7
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Omaha emergency medicine doctor uses drug in new way to treat anxiety and depression - KETV Omaha
An emergency room at a military hospital in Pohang, 262 kilometers southeast of Seoul, Feb. 20. Yonhap
Surgeries have been canceled and some patients were forced to be transferred to other hospitals as trainee doctors stopped working for the second day in a row Wednesday in protest of the government's plan to boost the number of medical students.
More than 6,400 trainee doctors nationwide, about 55 percent of the junior doctors, have submitted their resignations en masse so far, with about 1,600 of them walking off the job, according to the health ministry.
Medical services at the five biggest general hospitals in Seoul suffered partial disruptions Tuesday after interns and resident doctors did not show up for work following collective resignations as they protested the plan to raise the medical school admission quota by 2,000 seats next year.
To cope with a potential disruption to medical services, the government has extended operating hours at 97 public hospitals and opened emergency rooms at 12 military hospitals to the public.
"We are deeply disappointed and concerned that the collective action by trainee doctors has led to a disruption in medical services, such as the cancellation of surgeries," Second Vice Health Minister Park Min-soo told reporters.
"We cannot give justification to the actions of the doctors leaving their patients behind to protest a policy despite knowing what the collective action could result in," Park said.
Despite the government's back-to-work order, trainee doctors have shown no sign of backing down.
In a statement, the Korean Intern Resident Association, a major organization of trainee doctors, demanded the government withdraw the plan to increase the number of medical students.
Describing the plan as "ridiculous," the association criticized the government for treating trainee doctors as "criminals by overusing extrajudicial executive orders."
The government says the increase in the admission quota is needed to address a shortage of doctors, particularly in rural areas and essential medical fields, such as high-risk surgeries, pediatrics, obstetrics and emergency medicine.
The number of doctors in South Korea relative to the size of the population is among the lowest in the developed world, according to health authorities.
But doctors have claimed that the government has not had full consultations on the matter and that the move will compromise the quality of medical education and services. (Yonhap)
Originally posted here:
Concerns over public health heighten as trainee doctors walk off job for 2nd day -
LifeFlight of Maine has launched a significant new initiative to bolster its relationships with hospitals, first responders, emergency medical services (EMS), 911 centers, and other stakeholders that rely on LifeFlight to deliver critical care quickly and reliably for patients facing a life-threatening medical emergency.
This initiative will be led by Kyle Madigan, director of client relations at LifeFlight of Maine, who began in this newly created role in January 2024. Madigan brings decades of experience as a flight nurse and critical care provider, an educator, and an air medical program administrator. Most recently, he led the Dartmouth Hitchcock Advanced Response Team (DHART), LifeFlight of Maines peer service based in Lebanon, New Hampshire.
Under Madigans leadership, LifeFlight is working to expand its outreach and education efforts across all 16 counties in Maine, as well as parts of New Hampshire along the border with Maine, an area in which LifeFlight of Maines Sanford-based team provides service when needed. These efforts include expanding offerings of LifeFlights Ground Safety and User Course, which trains partner agencies on how to identify when a patient needs a LifeFlight transport, how to make a transport request, how to safely secure a landing zone, and how to transfer the patient into LifeFlights care.
Madigan, in concert with LifeFlight of Maine CEO Joe Kellner, is also leading efforts to strengthen operational collaboration between LifeFlight and Maines hospitals. The majority of calls to LifeFlight come from a hospital requesting to transfer an acutely ill patient to a facility that offers a higher level of care. This is a critically important service for Maines geographically dispersed system of community hospitals. The smooth, reliable, and rapid movement of these patients in a LifeFlight vehicle is critical both to the patients outcomes and to the capacity of the emergency medical system statewide to ensure all patients can access the care they need. Madigan will work with leaders and clinicians in emergency departments and intensive care units to improve coordination and logistics for the care teams interfacing with LifeFlight crews.
Additionally, LifeFlight is working with communities, first responders, and private citizens to establish additional helicopter landing zones in rural areas. LifeFlight maintains a database of thousands of landing zones across Maine and parts of New Hampshire, which LifeFlight crews utilize to respond to medical emergencies. Many of these landing zones are a local ball field or parking lot. Others are a clearing deep in the Maine woods. By working with communities to expand this database, which is available both to LifeFlight and to 911 dispatchers statewide, LifeFlight is creating more critical healthcare access points across Maine.
At LifeFlight of Maine, we hold ourselves to uncompromising standards of excellence. This is what has inspired this organization for two and a half decades, and what continues to drive us as one of the premier nonprofit air ambulance and critical care services in the country. We are continually looking for ways to elevate the level of care we provide to our patients, and to improve the reliability and speed of the service we offer to every community here in Maine. This new initiative continues our longstanding commitment to excellence, said Joe Kellner, CEO, LifeFlight of Maine.
Kyle Madigans experience and expertise in the delivery of critical care emergency medicine is formidable. The work he is doing to strengthen collaboration between LifeFlight and our EMS and hospital partners is a tremendous asset both to this organization and to the entire Maine EMS system, fundamentally because this initiative will improve patient care and save lives, said Bill Cyr, COO, LifeFlight of Maine.
I have dedicated my career to nonprofit, critical care emergency medicine, because I firmly believe that this is the best delivery model for patients in Maine, northern New England, and beyond. I have worked in collaboration with my colleagues at LifeFlight of Maine for years, and Im pleased to now have the opportunity to serve alongside them. Maine is fortunate to have an air medical provider as well-regarded as LifeFlight, and I look forward to contributing my skills to this team and to the State of Maine, said Kyle Madigan, director of client relations, LifeFlight of Maine.
LifeFlight of Maine is a nonprofit and the states only air ambulance service. Since 1998, LifeFlight has transported more than 38,000 patients, one life at a time, from every community in Maine. LifeFlights mission is to transform the critical care transport medicine system into an integrated, high-quality, patient-centered system worthy of the publics trust. LifeFlights airplane and five helicopters are based in Bangor, Lewiston, and Sanford. Along with dedicated ground ambulances, these vehicles cover the entire state and offshore islands. LifeFlight complements and supports the work of local EMS and hospital personnel in caring for the critically ill or injured. Each LifeFlight base is staffed by a highly qualified team of pilots, flight nurses and flight paramedics, EMT vehicle operators, aviation maintenance technicians, and communications specialists. LifeFlight of Maine is a joint venture partnership of Central Maine Healthcare and Northern Light Health. LifeFlight was fully re-accredited by the Commission on Accreditation of Medical Transport Systems in 2022. More information about LifeFlight of Maine is available at LifeFlightMaine.org.
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The following is a summary of Influence of Patient and Clinician Gender on Emergency Department HEART Scores: A Secondary Analysis of a Prospective Observational Trial, published in the February 2024 issue of Emergency Medicine by Barron, et al.
Healthcare gaps can be reduced with the help of clinical decision tools. However, many clinical decision tools have subjective factors that could bring bias from the doctor. The HEART score is a clinical decision that helps doctors tell how likely a patient in the emergency department (ED) will have a heart attack.
For a study, researchers sought to find out how gender affects HEART scores for both patients and clinicians.
They looked at a random group of adult ED patients at one hospital who came in with signs of acute cardiac syndrome in this secondary analysis of a prospective observational study. They looked at HEART scores made by ED clinicians and scores made by researchers who didnt know what gender the patient was. The main result was whether the HEART numbers given by the physician and researcher were the same for each patients gender and each therapists gender. They used difference-in-difference (DiD) to compare continuous scores and prevalence-adjusted, bias-adjusted Kappa (PABAK) to compare binary scores (low risk vs. moderate/high risk). All 336 pairs of clinicians and patients from the original study were considered. 47% of the patients were women (158/336), and 52% were handled by women clinicians (174/336).
The difference between the doctors and researchers HEART scores for male and female patients was 0.24 (95% CI 0.01 to 0.48). They found that male clinicians gave male patients a higher score than female patients (DiD 0.51 [95% CI 0.16 to 0.87]), but female clinicians did not (DiD 0.00 [95% CI 0.33 to 0.33]). It was most agreed upon between female clinicians (PABAK 0.72; 95% CI 0.61 to 0.81) and least agreed upon between male clinicians evaluating male patients (PABAK 0.47; 95% CI 0.29 to 0.66). The gender of the patient and the doctor may affect the HEART score. When this and other professional decision aids are being made and used, researchers should try to understand these factors.
Source: sciencedirect.com/science/article/abs/pii/S0196064423001993
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Analyzing the Gender's Impact on ED HEART Scores - Physician's Weekly
Two weeks after the patients death on Sept. 13, state health inspectors arrived at the hospital, owned by for-profit Steward Health Care, to investigate. During their review of patient records, they found an emergency department with recurring staffing problems that at times seemed to be in near-meltdown.
Extremely sick patients had no assigned nurses, including one patient who was previously found unresponsive in a hallway. In another instance, an overworked nurse who was extremely busy and was behind, trying to catch up left a patient who had been vomiting in the waiting room for more than 10 hours. A friend discovered the patient barely conscious; the person was intubated and admitted to the intensive care unit, according to a state inspection report. It is unclear from the report if those patients survived, and hospital officials declined to provide that information.
State and federal officials declared the safety lapses put patients in immediate jeopardy, a severe sanction that required Good Samaritan to develop a plan within 23 days to fix its emergency department or risk losing its Medicare funding. Good Samaritan executives said they addressed the problems immediately, including bringing in more staff.
The hazards in the hospitals emergency department should not have been a surprise to state and federal regulators. Inspectors for the Massachusetts Department of Public Health had found serious patient safety violations in Good Samaritans emergency department three other times since 2021, documents obtained by the Globe show. After each inspection, investigators required the hospital to produce an improvement plan, but their visits resulted in little lasting change.
It wasnt until Jan. 31, when the seriousness of the financial crisis engulfing the company had become public, that the health department began sending daily monitors to Good Samaritan and other Steward hospitals, raising concerns about why the state didnt do more sooner.
While emergency departments are under strain across Massachusetts and the country, staff at Good Samaritan have been especially overwhelmed as they try to treat thousands of additional patients after two nearby hospitals shut their doors. At the same time, nurses have told state inspectors that private equity-backed Steward has neglected to hire enough staff and buy enough supplies.
The Massachusetts Nurses Association, the union that represents nurses at the hospital, warned state and federal health officials in 2021 and 2022 about the deterioration of the emergency department. Among the problems they cited: the potentially avoidable deaths of two patients, patients without nurses, patients being left in the waiting room for hours without being reevaluated, and managements failure to follow through on its promises, according to a letter and a memo obtained by the Globe.
Last March, emergency room nurses spoke directly to Governor Maura Healey, Lieutenant Governor Kim Driscoll, and Secretary of Health and Human Services Kate Walsh about their concerns when Massachusetts officials visited Good Samaritan after a fire shut down nearby Brockton Hospital.
In September, on the day the patient died while in the registration line, 19 nurses were supposed to be on duty, according to an internal staffing report. There were eight.
Dr. Robbie Goldstein, commissioner of the state Department of Public Health, said the patients death was a tragic event and for all us it really gave us significant pause. But he said inspectors have provided close oversight of the Good Samaritan emergency department since 2021; the department thoroughly investigated every complaint, required an improvement plan, and revisited the hospital once after each plan was submitted to ensure its implementation, he told the Globe.
He acknowledged the department did not send in regular monitors until two weeks ago, but said that step has traditionally been taken only during nursing strikes.
Do I think that we will change the way that we provide oversight, evaluate facilities, and intervene at times of financial distress? Absolutely. That story is being written right now, Goldstein said.
He said he recognizes the situation at Good Samaritan and other Steward hospitals is hard for patients and Steward staff. We are working 24/7 with Steward and with the rest of health care to make sure that we can address the challenges that people are facing, he added.
The inspections of Good Samaritan were conducted by state officials on behalf of the US Centers for Medicare and Medicaid Services, which issues reports called statements of deficiencies when it finds problems. Those reports include descriptions of incidents but not patients names or other identifying details.
In a statement emailed to the Globe, Good Samaritan president Matt Hesketh said that after the immediate jeopardy findings on Sept. 26 and 28, the hospital immediately hired technicians to help assess the vital signs of patients in the waiting room, and deployed nurse practitioners and physician assistants to help triage walk-in patients steps that were part of the improvement plan. The hospital also is offering $40,000 signing bonuses to nurses hired to work in the emergency department.
Inspectors from the Centers for Medicare and Medicaid Services recently visited the hospital and we remain in full compliance with all guidelines and protocols, Hesketh said.
We have faced unprecedented challenges over the past few years, however, the safety of our patients and providing excellent, compassionate care is our focus day in and day out, he added.
Goldstein, however, said that monitors stationed at Good Samaritan and other Steward hospitals have received additional complaints about patient care, and that the department is investigating the allegations. He did not describe the nature of them.
Experts in emergency medicine and patient safety consulted by the Globe could not assess whether the issues at Good Samaritan were more severe than elsewhere.
Theres a lot of bad things there, said Dr. Joseph C. Tennyson, president of the Massachusetts College of Emergency Physicians, an advocacy group for doctors, after being told of the reports. But he added, Bad things like this are happening everywhere right now because the capacity doesnt exist.
Just two weeks ago, the state Department of Public Health designated hospitals in Greater Boston and north of the city as Tier 3, meaning they have a high risk of capacity problems throughout their hospitals and need to meet more frequently with health officials and one another to coordinate patient load. Good Samaritan and other hospitals south of Boston have been in Tier 3 for the past year, after Brockton Hospital closed.
Patients have suffered because of delays at other hospitals. A disabled patient became unresponsive in the emergency department waiting room at Cooley Dickinson Hospital in Northampton in November 2022, during a six-hour wait for care. He died several hours later.
The patient, a 74-year-old man, checked in about 8:30 p.m. complaining of a cough and other respiratory symptoms. The triage nurse ordered lab tests and a chest X-ray and sent him to the waiting room, but failed to measure his blood oxygen level, according to a state inspection report. Another nurse told inspectors the triage nurse was running behind and there were too many patients waiting to be triaged. When his guardian the man was disabled, according to a relative told staff he did not look well, they found him unresponsive. Death records show he had the flu and pneumonia, and died of sepsis.
Laura Oggeri, a spokesperson for Mass General Brigham, which owns Cooley Dickinson, said that she could not discuss a specific case due to patient confidentiality rules, but that the hospital now requires mandatory additional medical reassessments for those waiting for care.
While many emergency departments are struggling with severe overcrowding amid a national shortage of nurses, they differ in how effectively they respond, said Barbara Fain, executive director of the Betsy Lehman Center for Patient Safety, a Massachusetts state agency.
We do know that there is wide variability in the safety cultures of different hospitals, and that is really driven by the leadership, she said.
Dr. Zirui Song, associate professor of health care policy and medicine at Harvard Medical School, said the circumstances at Good Samaritan might be attributable to staffing reductions. A study he and others published in December found that after hospitals are acquired by a private equity company, they experience a 25 percent increase in adverse events, such as infections and falls. This is happening even as other hospitals are seeing a decline in such events, he said.
One of the primary hypotheses that we have is that staffing reductions after a private equity acquisition might explain these findings, Song said, and that might apply as well to the emergency department.
Song, an internist at Massachusetts General Hospital, called what happened to patients at Good Samaritan gut-wrenching and heart-breaking and not something he would expect to see at Mass. General, even when the emergency department is extremely busy. Patients with chest pain and shortness of breath are typically worked up fairly rapidly, he said.
So the fact the E.D. is full does not mean that these adverse events . . . are acceptable or expected, he said.
But sometimes they are unavoidable, said Tennyson, the emergency physicians group president. As an emergency department physician, he said, he has seen patients designated ESI 2 the second most severe level of patient illness who have waited 14 hours or longer. Ideally a patient with chest pain would be seen right away and get an electrocardiogram, a recording of the hearts electrical activity that can help diagnose a heart attack, within 10 minutes, said Tennyson, who is chief of emergency medicine at UMass Memorial HealthAlliance-Clinton Hospital.
But its not uncommon for a chest pain patient to have to wait in a busy ER, because there are five or six people or more that are having chest pain, and most of them are not having a heart attack, Tennyson said.
Those situations are painful and demoralizing for the staff, he said.
To see somebody in the waiting room that you absolutely know you need to go see, that you need to get seen right away, and theres no way to do it thats injurious and its contributing to burnout, he said.
Liz Kowalczyk can be reached at lizbeth.kowalczyk@globe.com. Felice J. Freyer can be reached at felice.freyer@globe.com. Follow her @felicejfreyer.
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Steward Health Care news: ER near Boston put patients in jeopardy - The Boston Globe
With the advent of artificial intelligence (AI), the field of neuroscience is undergoing a transformation. The sheer complexity and intricate dynamics of the human brain have been a challenge for neuroscientists. With the explosion of data, the gap between information and knowledge is becoming increasingly apparent. However, AI is starting to bridge this gap, providing profound insights into the workings of the human brain and paving the way for unprecedented discoveries.
AI is progressively becoming a potent tool in understanding the human brain, simulating the way neurons connect and fire. By mimicking the human brains structure and function, AI algorithms can simulate how the virtual brain reacts to stimuli. This offers invaluable insights into the real brains processes. AIs ability to identify subtle patterns in brain activity is instrumental in accelerating progress in neuroscience research. It is even beginning to demonstrate abilities in understanding the emotional tone in language and generating creative text formats. The application of AI in neuroscience is transforming biology into an engineering discipline, driving innovation and opening doors to unimaginable discoveries.
Publications like the BRAIN journal underscore the intersection of artificial intelligence, cognitive sciences, and neuroscience. Listed in online libraries of universities and organizations, the journal provides original contributions in these fields, emphasizing the increasing reliance of neuroscience on AI. As such, it is clear that AI tools are streamlining neuroscience research, accelerating the pace of innovation and progress in the field.
Elemind, an AI-enhanced neurotech health company, is an excellent example of how AI is revolutionizing neuroscience. With a $12M Seed round, Elemind is developing wearable neurotechnology that reads individual brainwaves and guides them in real-time. This real-time guidance changes behavior in a more targeted, smarter, and natural way than pharmaceuticals, a method which Elemind describes as electric medicine. This adaptive, drug-free approach fine-tunes stimulation based on the bodys response until the desired state is achieved. The technology, backed by five clinical trials and several peer-reviewed scientific journals, has shown effectiveness in inducing sleep, suppressing essential tremors, boosting memory, increasing pain thresholds, and enhancing sedation. Eleminds dynamic neurostimulation techniques and core signal processing algorithms are covered by three critical patents.
At Imperial College London, the Neural Reckoning Group, led by Dan Goodman, is using spiking neural networks to understand how biological and artificial brains reckon or compute. This research is another testament to the potential of AI in neuroscience, showing how AI can be used to decipher the complex computations in both biological and artificial brains.
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Role of AI in Neuroscience Research and Understanding of the Human Brain - Medriva
Summary: A groundbreaking study uncovered the brains remarkable ability to compensate for age-related decline by activating additional regions to maintain cognitive performance.
This research demonstrates that older adults can indeed enhance their task performance through the brains adaptive recruitment of other areas, particularly the cuneus region, which is not typically associated with the multiple demand network (MDN) involved in fluid intelligence tasks.
By analyzing fMRI scans of 223 adults during problem-solving tasks, the study reveals a nuanced understanding of how the brain navigates the challenges of aging, potentially opening pathways to interventions that could bolster cognitive health in older populations.
This comprehensive analysis underscores the complexity of brain function and adaptation, offering hope for mitigating the effects of aging on cognitive abilities.
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Source: University of Cambridge
Scientists have found the strongest evidence yet that our brains can compensate for age-related deterioration by recruiting other areas to help with brain function and maintain cognitive performance.
As we age, our brain gradually atrophies, losing nerve cells and connections and this can lead to a decline in brain function. Its not fully understood why some people appear to maintain better brain function than others, and how we can protect ourselves from cognitive decline.
A widely accepted notion is that some peoples brains are able to compensate for the deterioration in brain tissue by recruiting other areas of the brain to help perform tasks. While brain imaging studies have shown that the brain does recruit other areas, until now it has not been clear whether this makes any difference to performance on a task, or whether it provides any additional information about how to perform that task.
In a study published in the journaleLife, a team led by scientists at the University of Cambridge in collaboration with the University of Sussex have shown that when the brain recruits other areas, it improves performance specifically in the brains of older people.
Study lead Dr Kamen Tsvetanov, an Alzheimers Society Dementia Research Leader Fellow in the Department of Clinical Neurosciences, University of Cambridge, said: Our ability to solve abstract problems is a sign of so-called fluid intelligence, but as we get older, this ability begins to show significant decline.
Some people manage to maintain this ability better than others. We wanted to ask why that was the case are they able to recruit other areas of the brain to overcome changes in the brain that would otherwise be detrimental?
Brain imaging studies have shown that fluid intelligence tasks engage the multiple demand network (MDN), a brain network involving regions both at the front and rear of the brain, but its activity decreases with age.
To see whether the brain compensated for this decrease in activity, the Cambridge team looked at imaging data from 223 adults between 19 and 87 years of age who had been recruited by theCambridge Centre for Ageing & Neuroscience (Cam-CAN).
The volunteers were asked to identify the odd-one-out in a series of puzzles of varying difficulty while lying in a functional magnetic resonance imaging (fMRI) scanner, so that the researchers could look at patterns of brain activity by measuring changes in blood flow.
As anticipated, in general the ability to solve the problems decreased with age. The MDN was particularly active, as were regions of the brain involved in processing visual information.
When the team analysed the images further using machine-learning, they found two areas of the brain that showed greater activity in the brains of older people, and also correlated with better performance on the task.
These areas were the cuneus, at the rear of the brain, and a region in the frontal cortex. But of the two, only activity in the cuneus region was related to performance of the task more strongly in the older than younger volunteers, and contained extra information about the task beyond the MDN.
Although it is not clear exactly why the cuneus should be recruited for this task, the researchers point out that this brain region is usually good at helping us stay focused on what we see.
Older adults often have a harder time briefly remembering information that they have just seen, like the complex puzzle pieces used in the task. The increased activity in the cuneus might reflect a change in how often older adults look at these pieces, as a strategy to make up for their poorer visual memory.
Dr Ethan Knights from the Medical Research Council Cognition and Brain Sciences Unit at Cambridge said: Now that weve seen this compensation happening, we can start to ask questions about why it happens for some older people, but not others, and in some tasks, but not others. Is there something special about these people their education or lifestyle, for example and if so, is there a way we can intervene to help others see similar benefits?
Dr Alexa Morcom from the University of Sussexs School of Psychology and Sussex Neuroscience research centre said: This new finding also hints that compensation in later life does not rely on the multiple demand network as previously assumed, but recruits areas whose function is preserved in ageing.
Funding: The research was supported by the Medical Research Council, the Biotechnology and Biological Sciences Research Council, the European Unions Horizon 2020 research and innovation programme, the Guarantors of Brain, and the Alzheimers Society.
Author: Craig Brierley Source: University of Cambridge Contact: Craig Brierley University of Cambridge Image: The image is credited to Neuroscience News
Original Research: Open access. Neural Evidence of Functional Compensation for Fluid Intelligence Decline in Healthy Ageing by Kamen Tsvetanov et al. eLife
Abstract
Neural Evidence of Functional Compensation for Fluid Intelligence Decline in Healthy Ageing
Functional compensation is a common notion in the neuroscience of healthy ageing, whereby older adults are proposed to recruit additional brain activity to compensate for reduced cognitive function. However, whether this additional brain activity in older participants actually helps their cognitive performance remains debated.
We examined brain activity and cognitive performance in a human lifespan sample (N=223) while they performed a problem-solving task (based on Cattells test of fluid intelligence) during functional magnetic resonance imaging (fMRI).
Whole-brain univariate analysis revealed that activity in bilateral cuneal cortex for hard vs. easy problems increased both with age and with performance, even when adjusting for an estimate of age-related differences in cerebrovascular reactivity.
Multivariate Bayesian decoding further demonstrated that age increased the likelihood that activation patterns in this cuneal region provided non-redundant information about the two task conditions, beyond that of the multiple-demand network generally activated in this task.
This constitutes some of the strongest evidence yet for functional compensation in healthy ageing, at least in this brain region during visual problem-solving.
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Brain's Method for Preserving Cognition in Aging Revealed - Neuroscience News