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High Rates of Suicidal Ideation in Rural Black Men – Neuroscience News

Summary: A new study highlights the alarming rates of suicidal thoughts among rural Black men, attributing significant causes to childhood adversity and racism. This research, involving over 500 African American men, demonstrates that experiences of economic hardship, trauma, and racial discrimination significantly impact mental health, leading to a sense of isolation and thoughts of suicide.

The findings emphasize the critical role of healthy relationships and community support in mitigating suicidal ideation. Furthermore, the study underscores the importance of addressing the effects of racism from childhood through adulthood to improve mental health outcomes for young Black men.

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Source: University of Georgia

One in three rural Black men reported they experienced suicidal ideation or thoughts of death in the past two weeks, reports anew studyfrom the University of Georgia. Childhood adversity and racism may hold much of the blame.

Suicide is the second leading cause of death for African Americans between the ages of 15 and 24, according to the Centers for Disease Control and Prevention. Suicide is particularly prevalent among Black men, who die by suicide at a rate more than four times that of Black women.

It feels like nobody is talking about the problem. And its only getting worse.

I think we often dont look at where the disparities are and who the individuals most at risk are when were talking about suicide ideation, said Michael Curtis, co-author of the study and a graduate of UGAs Human Development and Family Science Department in theCollege of Family and Consumer Sciences.

We just know its bad, and particularly among young Black men.

Historically, research has not invested a lot of time and effort in looking into what are the unique cultural contexts that make certain men more at risk for suicidal thoughts than other men.

The study found that growing up in a low-resource environment and experiencing racial discrimination during young adulthood makes it difficult to engage in healthy, trusting relationships. Strong feelings of mistrust and caution toward social relationships can lead to feelings of isolation, which in turn can prompt thoughts of death and suicide.

Childhood trauma, racism take heavy toll on young Black men

The researchers followed more than 500 African American men from their late teens through early 20s in rural Georgia.

At three separate times over the course of several years, the men were asked to reflect on their childhood, including economic hardships and traumatic experiences.

Some of the questions included whether they experienced physical or emotional abuse, witnessed a relative being abused, felt loved and special, had enough to eat or had access to medical care when needed as a child.

Study participants were also asked about their feelings and beliefs about close relationships, such as trust in romantic partners, and concerns about being taken advantage of in relationships as well as how often in the past six months they had been treated unfairly because of their race.

Finally, the researchers asked the participants about depressive symptoms and how often they had thoughts about death or killing themselves in the past two weeks.

The researchers found that these childhood experiences with trauma, deprivation and racism took a heavy toll on study participants mental health as they entered adulthood.

We found when Black men were exposed to childhood adversity, they may develop an internal understanding of the world as somewhere they are devalued, where they could not trust others, and they could not engage the community in a supportive way, said Curtis, who practices as a licensed marriage and family therapist.

Engaging with social support is critical for young Black men who experience many challenges to success.

Young Black men experience higher rates of poverty than white peers

Young Black men in general, and those living in rural areas in particular, are disproportionately affected by childhood adversity. Theyre more likely to come from economically distressed families, grow up in low resource neighborhoods and experience trauma in their communities than their white peers.

Previous research has shown that racial discrimination increases the risks for depression, anxiety and psychological distress among Black children, adolescents and adults.

Although childhood neglect and trauma played a role in predicting suicidal thoughts, the researchers found that racial discrimination independently predicted higher rates of suicidal thoughts.

That means even participants who reported positive childhood experiences but experienced racial discrimination in young adulthood had a more difficult time developing and maintaining healthy relationships. As a result of that lack of community, they were more likely to experience thoughts of suicide.

The quality of our relationships is what sustains human beings, saidSteven Kogan, lead author of the study and a professor in UGAs College of Family and Consumer Sciences.

For people who have suicidal thoughts, theres this sense that no one knows me, nobody cares about me, theres nobody there for me, I am alone.

Healthy relationships can help prevent suicide

Those thoughts can set in quickly, and one of the biggest protective factors against suicide is healthy relationships, having someone to call when those feelings start to get overwhelming, the researchers said.

You dont wake up one day and say, You know, it would be better if I was gone. There are multiple factors in childhood and ones current context that inform suicidal thoughts.

To address these mens needs, we have to address how racism in childhood and adulthood erodes mental health and well-being.

Parents can play a key role in helping their children cope with these struggles, the researchers said.

More research is needed, but one finding is unequivocal: Loving yourself as a Black person is foundational, Kogan said.

Teaching children and youth to be proud of being Black counters the potential for them to internalize negative messages about Blackness that pervade U.S. society.

Published by Cultural Diversity and Ethnic Minority Psychology,the studywas co-authored by Ava Reck, a doctoral candidate in UGAsHuman Development and Family Scienceprogram, andAssaf Oshri, an associate professor in the College of Family and Consumer Sciences.

Author: Cole Sosebee Source: University of Georgia Contact: Cole Sosebee University of Georgia Image: The image is credited to Neuroscience News

Original Research: Closed access. Childhood adversity and racial discrimination forecast suicidal and death ideation among emerging adult Black men: A longitudinal analysis by Steven Kogan et al. Cultural Diversity and Ethnic Minority Psychology

Abstract

Childhood adversity and racial discrimination forecast suicidal and death ideation among emerging adult Black men: A longitudinal analysis

Objectives: Disproportionate exposure to childhood adversity and the effects of racial discrimination take a toll on Black American mens mental health. Despite increasing rates of suicidal behaviors and thoughts among young adult, Black American men, few longitudinal studies examine their risk for suicidal and death ideation (SDI).

We tested a developmental model linking childhood adversity (experiences of deprivation and threatening experiences) and emerging adult exposure to racial discrimination to increases in SDI and examined a potential mechanism for these effects, negative relational schemas.

Method: A sample of 504 Black men (Mage= 20.7) from rural Georgia were recruited with respondent-driven sampling and completed a baseline survey. Men participated in two additional follow-up surveys (Mage= 21.9 andMage= 23.5). Hypotheses were tested using structural equation modeling.

Results: Analyses largely supported the proposed model. Childhood adversities were associated directly with reports of SDI. Childhood deprivation indirectly predicted SDI via negative schemas ( = 0.03, 95% CI [.014, .046]). Racial discrimination also indirectly predicted SDI via negative relational schemas ( = 0.01, 95% CI [.001, .018]).

Conclusion: Study results suggest that clinical and preventive interventions for suicidality should target the influence of racism and adverse experiences and the negative relational schemas they induce.

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Harmony in Chaos: How BPD Influences Music Tastes – Neuroscience News

Summary: Recent research reveals that individuals with Borderline Personality Disorder (BPD) exhibit distinct music preferences, favoring reflective and complex genres such as classical and jazz over intense, rebellious ones.

The study, involving 549 participants, highlights how the severity of BPD symptoms influences these preferences and the psychological functions of music, emphasizing its role in emotional regulation and social connectivity.

Musics functions act as mediators in forming these preferences, suggesting that musical tastes among individuals with BPD reflect their internal psychological needs. This insight opens new avenues for tailored music therapy interventions, promising more effective therapeutic outcomes.

Key Facts:

Source: Neuroscience News

In the intricate tapestry of human emotions and experiences, music stands as a universal language, capable of expressing the inexpressible and providing solace where words often fall short.

Its profound impact on our psychological well-being, mood regulation, and sense of connectedness with others is well-documented, yet the exploration of musics role in the lives of individuals with Borderline Personality Disorder (BPD) reveals new layers of complexity and significance.

Borderline Personality Disorder, a mental health condition characterized by emotional instability, impulsive behavior, and often tumultuous relationships, affects millions worldwide. Individuals with BPD experience intense emotions and a persistent feeling of emptiness, leading to a continuous search for ways to cope and find stability.

In this context, a new study published in the Psychology of Music sheds light on how those with BPD engage with music, revealing distinct preferences and the psychological functions that music serves for them.

The study, spearheaded by Rafa Lawendowski of the University of Gdansk, delved into the music preferences of 549 individuals, 274 of whom exhibited symptoms of BPD.

By utilizing the Short Test of Music Preferences (STOMP) and assessing the psychological functions attributed to music, the research aimed to uncover how the severity of BPD symptoms interacts with music preferences and the underlying psychological needs music fulfills for these individuals.

Reflective Music for Emotional Regulation

One of the studys key findings is the clear preference among individuals with higher BPD symptom severity for reflective and complex music genres, such as classical and jazz. This contrasts sharply with less interest in intense and rebellious genres like heavy metal or punk.

This preference suggests a search for genres that promote introspection, complexity, and emotional depth, possibly serving as a form of emotional regulation and self-awareness enhancement.

The Psychological Functions of Music

Beyond mere preference, the study illuminated how individuals with BPD perceive the functions of music differently, particularly in terms of self-awareness and social connectedness.

For those with more severe symptoms, musics capacity to foster self-awareness and facilitate social bonds was less valued, indicating a potential disconnect or altered perception of musics role in their emotional and social lives.

Music as a Mediator

Crucially, the research suggests that the functions of music can act as mediators in the relationship between BPD symptoms and music preferences. This mediation indicates that music preferences among individuals with BPD are not arbitrary but are deeply intertwined with their psychological needs and symptomatology.

The preference for or against certain genres may reflect an unconscious attempt to address internal psychological needs, such as the need for emotional regulation, identity formation, and social interaction.

Implications and Future Directions

This studys insights are not only fascinating for those interested in the psychological impacts of music but also carry significant implications for therapeutic practices.

Understanding the specific music preferences and the psychological needs that music fulfills for individuals with BPD can inform more tailored and effective music therapy interventions.

By aligning therapeutic goals with the inherent music preferences and psychological functions it serves, therapists can potentially enhance the therapeutic outcomes for individuals with BPD.

However, the study is not without its limitations. The reliance on self-reported measures and the lack of consideration for ongoing therapys influence on music preferences highlight areas for further research.

A longitudinal approach, considering variables such as stress levels and the impact of therapy on evolving music preferences, could provide deeper insights into the dynamic relationship between BPD, music, and therapy.

This study not only broadens our understanding of the intricate relationship between BPD and music preferences but also underscores the therapeutic potential of music.

As we continue to unravel the layers of how music interacts with our psyche, particularly among those with BPD, we open new pathways for healing, understanding, and connection.

In the chaotic symphony of life, music offers a unique form of harmony for those navigating the turbulent waters of Borderline Personality Disorder, proving once again its unparalleled capacity to touch the deepest parts of our human experience.

Author: Neuroscience News Communications Source: Neuroscience News Contact: Neuroscience News Communications Neuroscience News Image: The image is credited to Neuroscience News

Original Research: Closed access. Borderline personality disorder symptoms relationship with music use: Investigating the role of music preferences and functions of music by KarolinaKowalewska et al. Psychology of Music

Abstract

Borderline personality disorder symptoms relationship with music use: Investigating the role of music preferences and functions of music

Music preferences are molded with numerous personality variables, yet, this relation, as assumed in the study, may be mediated by functions of music expressing the psychological needs of the listener.

Not many studies are devoted to the music preferences of listeners with personality disorders, whereas, none investigate this topic among people with Borderline Personality Disorder (BPD). A correlational study that was conducted among 549 individuals (274 displayed BPD symptoms).

The main goal was to examine the extent to which the severity of BPD symptoms directly interacts with the following: (a) music preferences and (b) music function formation, and whether the functions of music can explain the mechanism through which BPD symptoms interact with music preference formation.

Using structural equation modeling (SEM), we demonstrated that the severity of BPD-spectrum symptoms is closely related to types of music preferred. In addition, BPD symptoms severity is substantially linked to the perception of the social relatedness and self-awareness functions of music, whereas emotional function seems to be independent of the BPD symptoms aggravation.

Finally, the functions of music can partly act as a mediator in shaping the mechanism of forming music preferences based on personality predispositions. Further music preference analyses among individuals with BPD is highly warranted.

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Harmony in Chaos: How BPD Influences Music Tastes - Neuroscience News

Study Links Diet, Diabetes, and Alzheimers – Neuroscience News

Summary: A new study explores the molecular connections between Type 2 diabetes and Alzheimers, supporting the notion of Alzheimers as Type 3 diabetes.

This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimers-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimers risk.

The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.

Key Facts:

Source: ASBMB

New research conducted in mice offers insights into whats going on at the molecular level that could cause people with diabetes to develop Alzheimers disease.

The study adds to a growing body of research on the links between Type 2 diabetes and Alzheimers disease, which some scientists have called Type 3 diabetes.

The findings suggest that it should be possible to reduce the risk of Alzheimers by keeping diabetes well controlled or avoiding it in the first place, according to researchers.

NarendraKumar, an associate professor at Texas A&M University in College Station, led the study.

We think that diabetes and Alzheimers disease are strongly linked, Kumar said, and by taking preventative or amelioration measures for diabetes, we can prevent or at least significantly slow down the progression of the symptoms of dementia in Alzheimers disease.

Kumar will present the new research atDiscover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, which is being held March 2326 in San Antonio.

Diabetes and Alzheimers are two of the fastest-growing health concerns worldwide. Diabetes alters the bodys ability to turn food into energy and affects an estimated 1 in 10 U.S. adults. Alzheimers, a form of dementia that causes progressive decline in memory and thinking skills, is among the top 10 leading causes of death in the United States.

Diet is known to influence the development of diabetes as well as the severity of its health impacts. To find out how diet could influence the development of Alzheimers in people with diabetes, the researchers traced how a particular protein in the gut influences the brain.

They found that a high-fat diet suppresses the expression of the protein, called Jak3, and that mice without this protein experienced a cascade of inflammation starting with the intestine, moving through the liver and on to the brain.

Ultimately, the mice showed signs of Alzheimers-like symptoms in the brain, including an overexpressed mouse beta-amyloid and hyperphosphorylated tau, as well as evidence of cognitive impairment.

Liver being the metabolizer for everything we eat, we think that the path from gut to the brain goes through liver, Kumar said.

His lab has been studying functions of Jak3 for a long time, he added, and they now know that the impact of food on the changes in the expression of Jak3 leads to leaky gut. This in turn results in low-grade chronic inflammation, diabetes, decreased ability of the brain to clear its toxic substances and dementia-like symptoms seen in Alzheimers disease.

The good news, according to Kumar, is that it may be possible to stop this inflammatory pathway by eating a healthy diet and getting blood sugar under control as early as possible.

In particular, people with prediabetes which includes an estimated 98 million U.S. adults could benefit from adopting lifestyle changes to reverse prediabetes, prevent the progression to Type 2 diabetes and potentially reduce the risk of Alzheimers.

Author: Anne Johnson Source: ASBMB Contact: Anne Johnson ASBMB Image: The image is credited to Neuroscience News

Original Research: The findings will be presented at Discover BMB

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Study Links Diet, Diabetes, and Alzheimers - Neuroscience News

Neuroscience and Society Series: Aligning Science with the Public’s Values – The Hastings Center

Hastings Center News Published March 22, 2024March 22, 2024Posted in Neuroscience

Research that involves implanting devices into the brains of human volunteers creates a special moral obligation that extends beyond the trial periodan obligation that researchers, device manufacturers, and funders owe to the volunteers. This is the conclusion of two new essays in the Hastings Center Report that launch a series on the ethical and social issues raised by brain research.

The Neuroscience and Society series is supported by the Dana Foundation and will be published in open-access format online over the next three years.

The series seeks to promote deliberative public engagement about neuroscience, writes Hastings Center senior research scholar Gregory E. Kaebnick, who leads the development of the series, in Neuroscience and Society: Supporting and Unsettling Public Engagement, the introductory essay. The ultimate goal of the Neuroscience and Society series is to contribute to a vitally important but somewhat uncertain political project often called alignment. The guiding thought in that project is that science should align with the publics values; it should take society in a direction thats good for society, as judged by society.

Following the introduction, two essays discuss post-trial ethical obligations raised by studies with cutting-edge neural devices that have a range of potential benefits, such as deep brain stimulation to alleviate psychiatric conditions and brain-computer interfaces to aid communication.

Brain Pioneers and Moral Entanglement: An Argument for Post-trial Responsibilities in Neural-Device Trials Sara Goering, Andrew I. Brown, and Eran Klein

Human participants in neural-device trials are brain pioneers, entrusting researchers with access to their brains. For many of these researchers, what should happen at the end of the study is a troubling question without a clear answer. Researchers and funders of neural-device trials owe something to participants that, we insist, exceeds the usual benefits of participating, write the authors. In many cases, it includes ensuring participants continued access to neural devices.

Identity Theft, Deep Brain Stimulation, and the Primacy of Post-trial Obligations Joseph J. Fins, Amanda R. Merner, Megan S. Wright, and Gabriel Lzaro-Muoz

When neuroethicists write about deep brain stimulation (DBS) via implanted neural devices, they sometimes resort to science fiction hyperboleimagining parables of cyborgs whose identities are hijacked by the technology, the essay begins. This is because with the implantation of such technology comes the threat of a loss of personal identity, that sense of self that is felt as unique to a person. But findings from two deep brain stimulation trials for traumatic brain injury and obsessive-compulsive disorder reveal that injury and illness rob individuals of personal identity and that neuromodulation can restore it. The early success of these interventions makes a compelling case for continued post-trial access to these technologies.

The series is developed with support from Hastings Center senior research scholar Erik Parens. and the guidance of a steering committee of six scholars:

Jennifer Chandler, University of Ottawa Winston Chiong, University of California San Francisco Joseph J. Fins, Weill Cornell Medical School Sara Goering, University of Washington Jonathan D. Moreno, University of Pennsylvania Oliver Rollins, University of Washington

Learn more about the series here.

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Neuroscience and Society Series: Aligning Science with the Public's Values - The Hastings Center

Hardwiring Your Brain: The Neuroscience Of Behaviour Change | TheHealthSite.com – TheHealthSite

Children Care World Down Syndrome Day: What Kind Of Dietary, Fitness Parameters Should Kids With Down Syndrome Have?

In December 2011, the UN General Assembly declared March 21 as 'World Down Syndrome Day'. Around the world, there is a need for more societal acceptance for people born with this disorder, so that they are rewarded with inclusivity, proper healthcare, career opportunities and everything else needed to live a regular life.

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Hardwiring Your Brain: The Neuroscience Of Behaviour Change | TheHealthSite.com - TheHealthSite

AI learned how to sway humans by watching a cooperative cooking game – Science News Magazine

If youve ever cooked a complex meal with someone, you know the level of coordination required. Someone dices this, someone sauts that, as you dance around holding knives and hot pans. Meanwhile, you might wordlessly nudge each other, placing ingredients or implements within the others reach when youd like something done.

How might a robot handle this type of interaction?

Research presented in late 2023 at the Neural Information Processing Systems, or NeurIPS, conference, in New Orleans, offers some clues. It found that in a simple virtual kitchen, AI can learn how to influence a human collaborator just by watching humans work together.

In the future, humans will increasingly collaborate with artificial intelligence, both online and in the physical world. And sometimes well want an AI to silently guide our choices and strategies, like a good teammate who knows our weaknesses. The paper addresses a crucial and pertinent problem, how AI can learn to influence people, says Stefanos Nikolaidis, who directs the Interactive and Collaborative Autonomous Robotic Systems (ICAROS)lab at the University of Southern California in Los Angeles, and was not involved in the work.

The new work introduces a way for AI to learn to collaborate with humans, without even practicing with us. It could help us improve human-AI interactions, Nikolaidis says, and detect when AI might take advantage of us whether humans have programmed it to do so, or, someday, it decides to do so on its own.

There are a few ways researchers have already trained AI to influence people. Many approaches involve whats called reinforcement learning (RL), in which an AI interacts with an environment which can include other AIs or humans and is rewarded for making sequences of decisions that lead to desired outcomes. DeepMinds program AlphaGo, for example, learned the board game Go using RL.

But training a clueless AI from scratch to interact with people through sheer trial-and-error can waste a lot of human hours, and can even presents risks if there are, say, knives involved (as there might be in a real kitchen). Another option is to train one AI to model human behavior, then use that as a tireless human substitute for another AI to learn to interact with. Researchers have used this method in, for example, a simple game that involved entrusting a partner with monetary units. But realistically replicating human behavior in more complex scenarios, such as a kitchen, can be difficult.

The new research, from a group at the University of California, Berkeley, used whats called offline reinforcement learning. Offline RL is a method for developing strategies by analyzing previously documented behavior rather than through real-time interaction. Previously, offline RL had been used mostly to help virtual robots move or to help AIs solve mazes, but here it was applied to the tricky problem of influencing human collaborators. Instead of learning by interacting with people, this AI learned by watching human interactions.

Humans already have a modicum of competence at collaboration. So the amount of data needed to demonstrate competent collaboration when two people are working together is not as much as would be needed if one person were interacting with an AI that had never interacted with anyone before.

In the study, the UC Berkeley researchers used a video game called Overcooked, where two chefs divvy up tasks to prepare and serve meals, in this case soup, which earns them points. Its a 2-D world, seen from above, filled with onions, tomatoes, dishes and a stove with pots. At each time step, each virtual chef can stand still, interact with whatever is in front of it, or move up, down, left or right.

The researchers first collected data from pairs of people playing the game. Then they trained AIs using offline RL or one of three other methods for comparison. (In all methods, the AIs were built on a neural network, a software architecture intended to roughly mimic how the brain works.) In one method, the AI just imitated the humans. In another, it imitated the best human performances. The third method ignored the human data and had AIs practice with each other. And the fourth was the offline RL, in which AI does more than just imitate; it pieces together the best bits of what it sees, allowing it to perform better than the behavior it observes. It uses a kind of counterfactual reasoning, where it predicts what score it would have gotten if it had followed different paths in certain situations, then adapts.

The AIs played two versions of the game. In the human-deliver version, the team earned double points if the soup was delivered by the human partner. In the tomato-bonus version, soup with tomato and no onion earned double points. After the training, the chefbots played with real people. The scoring system was different during training and evaluation than when the initial human data were collected, so the AIs had to extract general principles to score higher. Crucially, during evaluation, humans didnt know these rules, like no onion, so the AIs had to nudge them.

On the human-deliver game, training using offline RL led to an average score of 220, about 50 percent more points than the best comparison methods. On the tomato-bonus game, it led to an average score of 165, or about double the points. To support the hypothesis that the AI had learned to influence people, the paper described how when the bot wanted the human to deliver the soup, it would place a dish on the counter near the human. In the human-human data, the researchers found no instances of one person passing a plate to another in this fashion. But there were events where someone put down a dish and ones where someone picked up a dish, and the AI could have seen value in stitching these acts together.

The researchers also developed a method for the AI to infer and then influence humans underlying strategies in cooking steps, not just their immediate actions. In real life, if you know that your cooking partner is slow to peel carrots, you might jump on that role each time until your partner stops going for the carrots. A modification to the neural network to consider not only the current game state but also a history of their partners actions would give a clue as to what their partners current strategy is.

Again, the team collected human-human data. Then they trained AIs using this offline RL network architecture or the previous offline RL one. When tested with human partners, inferring the partners strategy improved scores by roughly 50 percent on average. In the tomato-bonus game, for example, the bot learned to repeatedly block the onions until people eventually left them alone. That the AI worked so well with humans was surprising, says study coauthor Joey Hong, a computer scientist at UC Berkeley.

Avoiding the use of a human model is great, says Rohan Paleja, a computer scientist at MIT Lincoln Laboratory in Lexington, Mass., who was not involved in the work. It makes this approach applicable to a lot of real-world problems that do not currently have accurate simulated humans. He also said the system is data-efficient; it achieved its abilities after watching only 20 human-human games (each 1,200 steps long).

Nikolaidis sees potential for the method to enhance AI-human collaboration. But he wishes that the authors had better documented the observed behaviors in the training data and exactly how the new method changed peoples behaviors to improve scores.

In the future, we may be working with AI partners in kitchens, warehouses, operating rooms, battlefields and purely digital domains like writing, research and travel planning. (We already use AI tools for some of these tasks.) This type of approach could be helpful in supporting people to reach their goals when they dont know the best way to do this, says Emma Brunskill, a computer scientist at Stanford University who was not involved in the work. She proposes that an AI could observe data from fitness apps and learn to better nudge people to meet New Years exercise resolutions through notifications (SN: 3/8/17). The method might also learn to get people to increase charitable donations, Hong says.

On the other hand, AI influence has a darker side. Online recommender systems can, for example,try to have us buy more, or watch more TV, Brunskill says, not just for this moment, but also to shape us into being people who buy more or watch more.

Previous work, which was not about human-AI collaboration, has shown how RL can help recommender systems manipulate users preferences so that those preferences would be more predictable and satisfiable, even if people didnt want their preferences shifted. And even if AI means to help, it may do so in ways we dont like, according to Micah Carroll, a computer scientist at UC Berkeley who works with one of the paper authors. For instance, the strategy of blocking a co-chefs path could be seen as a form of coercion. We, as a field, have yet to integrate ways for a person to communicate to a system whattypes of influence they are OK with, he says. For example, Im OK with an AI trying to argue for a specific strategy, but not forcing me to do it if I dont want to.

Hong is currently looking to use his approach to improve chatbots (SN: 2/1/24). The large language models behind interfaces such as ChatGPT typically arent trained to carry out multi-turn conversations. A lot of times when you ask a GPT to do something, it gives you a best guess of what it thinks you want, he says. It wont ask for clarification to understand your true intent and make its answers more personalized.

Learning to influence and help people in a conversation seems like a realistic near-term application. Overcooked, he says, with its two dimensions and limited menu, is not really going to help us make better chefs.

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AI learned how to sway humans by watching a cooperative cooking game - Science News Magazine

Rimjhim Agarwal selected as Major Symposium speaker at the American Association of Immunologists … – La Jolla Institute for Immunology

Rimjhim Agarwal, a UC San Diego Graduate Student and member of LJIs Weiskopf Lab (Image credit: La Jolla Institute for Immunology)

LA JOLLA, CALa Jolla Institute for Immunology (LJI) is pleased to announce the selection of Rimjhim Agarwal, 2024 Tullie and Rickey Families SPARK Awards for Innovations in Immunology (SPARK) winner, as a Major Symposium speaker for the American Association of Immunologists (AAI) IMMUNOLOGY2024 meeting. Agarwal joins 15 additional AAI trainee membersgraduate students and postdoctoral fellowswho were selected from 1,500 abstract submissions.

Agarwal, a UC San Diego Graduate Student and member of LJIs Weiskopf Lab, will present her research on how chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans. Chikungunya virus disease is transmitted by mosquitoes in tropical regions of Africa, Asia, and the Americas. The disease can be fatal, and many survivors are left with chronic, debilitating joint problems.

Almost 25 percent of infected individuals, predominantly women, develop chronic, arthritis-like symptoms, such as joint pain and swelling, said Agarwal in a recent LJI video interview. We dont know the cause of these symptoms, and we dont know why this happens primarily in women.

Agarwal recently won funding from The Rosemary Kraemer Raitt Foundation Trust through LJIs Tullie and Rickey Families SPARK Awards for Innovations in Immunology program to investigate these puzzling symptoms.

Rimjhim Agarwal on what we can learn from studying chikungunya virusand how her research may advance global health. (Filmed by LJI Creative Producer Matthew Ellenbogen)

This year marks the first time AAI has featured trainees in its annual conference Major Symposia. Agarwals talk will be part of the Immune Responses to Chronic Viral, Bacterial, Fungal, and Parasitic Infections Major Symposium, held on May 6. Agarwal will be joined by five faculty-level speakers and one other trainee-level speaker. She will also share her chikungunya virus research in a Poster Session.

AAIs annual meeting features the latest research from some of the brightest minds in the field of immunology, said Loretta Doan, CEO of The American Association of Immunologists. AAI trainee members are making exciting discoveries every day, and we are thrilled to offer this high-profile honor for some of them to share their work with the community.

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The La Jolla Institute for Immunology is dedicated to understanding the intricacies and power of the immune system so that we may apply that knowledge to promote human health and prevent a wide range of diseases. Since its founding in 1988 as an independent, nonprofit research organization, the Institute has made numerous advances leading toward its goal: life without disease. Visit lji.org for more information.

The American Association of Immunologists (AAI) is one of the worlds largest organizations of immunologists and scientists in related disciplines. Our mission is to improve global health and well-being by advancing immunology and elevating public understanding about the immune system. AAI members are responsible for some of the most significant biomedical discoveries of the past century, including the development of life-saving cancer immunotherapies, monoclonal antibodies, transplant technologies, and vaccines. We support scientists across the field of immunology through knowledge dissemination, community building, advocacy, and public outreach.

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Seeking new horizons: Where innovators find opportunities in a fast-changing immunology landscape – IQVIA

Unmet need is high in a long list of largely neglected immunological diseases, such as systemic lupus erythematosus, hidradenitis suppurativa, alopecia areata, Sjgren's syndrome, vitiligo, bullous pemphigoid or prurigo nodularis. Their prevalence spans a range from rare diseases with fewer than 200 thousand patients in the US, for example, to relatively more common conditions with a million or more patients, a subset of whom are severe cases most in need of innovative therapies. What they share is having been underserved, with typically limited disease-specific treatment options available to date, leaving many patients with poorly controlled disease. This represents an attractive opportunity for innovators to set an effective, new standard of care.

However, the natural history of these diseases is often less well understood and has led to several setbacks, e.g., in lupus. Nevertheless, innovators are clearly not disheartened, judging by recent pipeline momentum. For example, hidradenitis suppurativa has seen a major inflection point in development activity after many years of an innovation drought and was a key focus at the recent annual meeting of the American Academy of Dermatology (AAD), with several high-profile presentations of mid- to late-stage readouts, including AbbVies IL-1/1 antagonist lutikizumab, Novartis oral BTK inhibitor remibrutinib, and Moonlakes anti-IL-17 nanobody solenokimab.

The overall change in innovation intensity that we are witnessing across underserved immunology diseases is reminiscent of the momentum that transformed todays major autoimmune indications about 10-15 years ago. However, without such epidemiological scale, innovators today must play across multiple of those smaller indications to achieve critical mass in an immunology franchise, e.g., via a portfolio of assets and/or multi-indication assets.

Finding success in less explored immunology indications requires a different approach. Unlike the major, well-established autoimmune conditions such as RA, psoriasis or Crohns disease, smaller indications face unique challenges, for example, often low disease awareness among patients and HCPs, a limited understanding of the burden of illness and its true impact on patients life, immature care pathways, including diagnosis, specialist referral and treatment, leading to under-diagnosis and under-treatment, or convincing payers of the need to treat and for them to cover novel therapies.

Innovators targeting smaller, oft neglected immunology indications therefore must focus on three priorities:

As innovators re-direct their efforts towards historically underserved immunological diseases, long-suffering patients will be the ultimate winners, as the prospect of effective treatment options makes big strides towards becoming reality.

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Seeking new horizons: Where innovators find opportunities in a fast-changing immunology landscape - IQVIA

Researchers identify new way to inhibit immune cells that drive allergic asthma – EurekAlert

image:

Activation of ILC2s causes inflammation in mouse lungs (left), but this is reduced by treatment with Yoda1 to stimulate Piezo1 channels (right).

Credit: 2024 Hurrell et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20231835

Researchers at the Keck School of Medicine, University of Southern California, have discovered that a protein called Piezo1 prevents a type of immune cell in the lung from becoming hyperactivated by allergens. The study, to be published March 26 in the Journal of Experimental Medicine (JEM), suggests that switching on Piezo1 could represent a new therapeutic approach to reducing lung inflammation and treating allergic asthma.

Type 2 innate lymphoid cells (also known as ILC2s) are a type of immune cell that resides in the lungs, skin, and other tissues of the body. ILC2s in the lungs become activated in the presence of allergens and produce proinflammatory signals that drive the recruitment of other immune cells into the lungs. Unchecked, this can result in excessive inflammation and a tightening of the airways, making it difficult for asthma patients to properly breathe.

Given the importance of ILC2s in allergic asthma, there is an urgent need to develop novel mechanism-based approaches to target these critical drivers of inflammation in the lungs, says Omid Akbari, Professor of Immunology and Professor of Medicine at USCs Keck School of Medicine.

Akbari and colleagues discovered that, when they are activated by an allergen, ILC2s start to produce a protein called Piezo1 that can limit their activity. Piezo1 forms channels in the outer membranes of cells that open in response to mechanical changes in the cells environment, allowing calcium to enter the cell and change its activity.

Akbaris team found that, in the absence of Piezo1, mouse ILC2s became more active than normal in response to allergenic signals, and the animals developed increased airway inflammation. In contrast, treatment with a drug called Yoda1 that switches on Piezo1 channels reduced the activity of ILC2s, decreased airway inflammation, and alleviated the symptoms of allergen-exposed mice. The groups observations suggest a significant role for Piezo1 channels in ILC2 metabolism, as treatment with Yoda1 reduced ILC2 mitochondrial function and rewired the cells energy source.

Finally, the researchers determined that human ILC2s also produce Piezo1, and so they tested the effects of Yoda1 on mice whose ILC2s had been replaced with human immune cells.

Remarkably, treatment of these humanized mice with Yoda1 reduced airway hyperreactivity and lung inflammation, suggesting that Yoda1 may be used as a therapeutic tool to modulate ILC2 function and alleviate the symptoms associated with ILC2-dependent airway inflammation in humans, Akbari says. Future studies are therefore warranted to delineate the role of Piezo1 channels in human patients with asthma and develop Piezo1-driven therapeutics for the treatment of allergic asthma pathogenesis.

Hurrell et al. 2024. J. Exp. Med. https://rupress.org/jem/article-lookup/doi/10.1084/jem.20231835?PR

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About Journal of Experimental Medicine

Journal of Experimental Medicine (JEM) publishes peer-reviewed research on immunology, cancer biology, stem cell biology, microbial pathogenesis, vascular biology, and neurobiology. All editorial decisions on research manuscripts are made through collaborative consultation between professional scientific editors and the academic editorial board. Established in 1896, JEM is published by Rockefeller University Press, a department of The Rockefeller University in New York. For more information, visit jem.org.

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Journal of Experimental Medicine

Experimental study

Animals

Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity

26-Mar-2024

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Researchers identify new way to inhibit immune cells that drive allergic asthma - EurekAlert