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BD Increases Access to Cutting-Edge Image-Enabled, Spectral Cell Sorters – BioSpace

New BD FACSDiscover S8 Cell Sorters to Enable More Researchers to Push the Boundaries of Discovery

FRANKLIN LAKES, N.J., April 5, 2024 /PRNewswire/ -- BD (Becton, Dickinson and Company) (NYSE: BDX), a leading global medical technology company, today announced the global commercial release of new cell sorters that will enable more researchers in a broader range of fields, including cell biology, cancer research and immunology, to reveal insights that were previously invisible in traditional flow cytometry experiments.

The new BD FACSDiscover S8 Cell Sorters feature BD CellView Image Technology, profiled on the cover of the journal Science in 2022, and BD SpectralFX Technology bringing to market breakthrough innovations in real-time imaging and spectral flow cytometry. The three- and four-laser additions to the BD FACSDiscover S8 Cell Sorter family complement the five-laser instrument launched last year and provide scientists greater access, options, and flexibility to incorporate real-time imaging and spectral cell sorting technology in their labs.

"For my research in cellular biology, the instrument was perfectly configured when it came to number of lasers and imaging capabilities," said Daniel Schraivogel, Ph.D., a research staff scientist at EMBL, who estimates he had 600 hours working on the three-laser prototype. "It has the same sorting speed and software capabilities as the five-laser unit, making experiments extremely scalable on an easy-to-use instrument."

Using the FACSDiscover S8 Cell Sorters, researchers can confirm complex biological and spatial insights in real time, obtain individual cell images and isolate desired cells based on visual characteristics at high speeds, all within a simplified and easy to use workflow. BD CellView Image Technology improves sort and sample quality, bringing confidence to biological results and saving researchers time and cost in their downstream applications. This expedited time to insight expands capabilities for researchers to transform research and cell-based therapeutic development across numerous fields in drug discovery, immuno-oncology and genomics.

"In flow cytometry, there are often 'suspect' populations where cells are dead or dying, and doublets and cellular debris that can impact the integrity of experiments," Schraivogel continued. "In addition to the added value of spatial information that is needed for many projects in cell biology, infection biology and functional genomic screening, the imaging sorter allows us to better explore our cell populations and is used to validate true single-cell gating and sorting, to deliver better-quality cells and biological outputs."

The family of BD FACSDiscover Cell Sorters will be featured at upcoming conferences beginning with the American Association for Cancer Research (AACR) Annual Meeting, April 5-10, and is now available to order through local sales representatives. More information is available at bdbiosciences.com/S8.

About BD BD is one of the largest global medical technology companies in the world and is advancing the world of health by improving medical discovery, diagnostics and the delivery of care. The company supports the heroes on the frontlines of health care by developing innovative technology, services and solutions that help advance both clinical therapy for patients and clinical process for health care providers. BD and its more than 70,000 employees have a passion and commitment to help enhance the safety and efficiency of clinicians' care delivery process, enable laboratory scientists to accurately detect disease and advance researchers' capabilities to develop the next generation of diagnostics and therapeutics. BD has a presence in virtually every country and partners with organizations around the world to address some of the most challenging global health issues. By working in close collaboration with customers, BD can help enhance outcomes, lower costs, increase efficiencies, improve safety and expand access to health care. For more information on BD, please visit bd.com or connect with us on LinkedIn at http://www.linkedin.com/company/bd1/, X (formerly Twitter) @BDandCo or Instagram @becton_dickinson.

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SOURCE BD (Becton, Dickinson and Company)

Company Codes: NYSE:BDX

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BD Increases Access to Cutting-Edge Image-Enabled, Spectral Cell Sorters - BioSpace

We’ve had bird evolution all wrong – EurekAlert

image:

A greater flamingo in Mallorca, Spain. Unraveling a genetic mystery revealed that flamingos and doves are more distantly related than previously thought.

Credit: Daniel J. Field

An enormous meteor spelled doom for most dinosaurs 65 million years ago. But not all. In the aftermath of the extinction event, birds technically dinosaurs themselves flourished.

Scientists have spent centuries trying to organize and sort some 10,000 species of birds into one clear family tree to understand how the last surviving dinosaurs filled the skies. Cheap DNA sequencing should have made this simple, as it has for countless other species.

But birds were prepared to deceive us.

In a pair of new research papers released today, April 1, scientists reveal that another event 65 million years ago misled them about the true family history of birds. They discovered that a section of one chromosome spent millions of years frozen in time, and it refused to mix together with nearby DNA as it should have.

This section, just two percent of the bird genome, convinced scientists that most birds could be grouped into two major categories, with flamingos and doves as evolutionary cousins. The more accurate family tree, which accounts for the misleading section of the genome, identifies four main groups and identifies flamingos and doves as more distantly related.

My lab has been chipping away at this problem of bird evolution for longer than I want to think about, said Edward Braun, Ph.D., the senior author of the paper published in the Proceedings of the National Academy of Sciences and a professor of biology at the University of Florida. We had no idea there would be a big chunk of the genome that behaved unusually. We kind of stumbled onto it.

Braun supervised an international team of collaborators led by Siavash Mirarab, a professor of computer engineering at the University of California San Diego, to publish their evidence that this sticky chunk of DNA muddied the true history of bird evolution. Mirarab and Braun also contributed to a companion paper published in Nature that outlines the updated bird family tree, which was led by Josefin Stiller at the University of Copenhagen.

Both papers are part of the B10K avian genomics project led by Guojie Zhang of Zhejiang University, Erich Jarvis of Rockefeller University, and Tom Gilbert of the University of Copenhagen.

Ten years ago, Braun and his collaborators pieced together a family tree for the Neoaves, a group that includes the vast majority of bird species. Based on the genomes of 48 species, they split the Neoaves into two big categories: doves and flamingos in one group, all the rest in the other. When repeating a similar analysis this year using 363 species, a different family tree emerged that split up doves and flamingos into two distinct groups.

With two mutually exclusive family trees in hand, the scientists went hunting for explanations that could tell them which tree was correct.

When we looked at the individual genes and what tree they supported, all of a sudden it popped out that all the genes that support the older tree, theyre all in one spot. Thats what started the whole thing, Braun said.

Investigating this spot, Brauns team noticed it was not as mixed together as it should have been over millions of years of sexual reproduction. Like humans, birds combine genes from a father and a mother into the next generation. But birds and humans alike first mix the genes they inherited from their parents when creating sperm and eggs. This process is called recombination, and it maximizes a species genetic diversity by making sure no two siblings are quite the same.

Brauns team found evidence that one section of one bird chromosome had suppressed this recombination process for a few million years around the time the dinosaurs disappeared. Whether the extinction event and the genomic anomalies are related is unclear.

The result was that the flamingos and doves looked similar to one another in this chunk of frozen DNA. But taking into account the full genome, it became clear that the two groups are more distantly related. Whats surprising is that this period of suppressed recombination could mislead the analysis, Braun said. And because it could mislead the analysis, it was actually detectable more than 60 million years in the future. That's the cool part.

Such a mystery could be lurking in the genomes of other organisms as well.

We discovered this misleading region in birds because we put a lot of energy into sequencing birds genomes, Braun said. I think there are cases like this out there for other species that are just not known right now.

This work was supported in part by the National Science Foundation.

Proceedings of the National Academy of Sciences

Data/statistical analysis

Not applicable

A region of suppressed recombination misleads neoavian phylogenomics

1-Apr-2024

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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We've had bird evolution all wrong - EurekAlert

Altered brain morphology and functional connectivity in postmenopausal women – EurekAlert

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Figure 6.Between-group comparison map (premenopausal women vs. postmenopausal women) of the left mOFC functional connectivity.

Credit: 2024 Kim et al.

[...] our findings suggest that diminished brain volume and functional connectivity may be linked to menopause-related symptoms caused by the lower sex hormone levels.

BUFFALO, NY- April 1, 2024 A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI.

The transition to menopause is associated with various physiological changes, including alterations in brain structure and function. However, menopause-related structural and functional changes are poorly understood. In this new study, researchers Gwang-Won Kim, Kwangsung Park, Yun-Hyeon Kim, and Gwang-Woo Jeong from Chonnam National University not only compared the brain volume changes between premenopausal and postmenopausal women, but also evaluated the functional connectivity between the targeted brain regions associated with structural atrophy in postmenopausal women.

To the best of our knowledge, no comparative neuroimaging study on alterations in the brain volume and functional connectivity, especially focusing on the thalamic subnuclei in premenopausal vs. postmenopausal women has been reported.

Each of the 21 premenopausal and postmenopausal women underwent magnetic resonance imaging (MRI). T1-weighted MRI and resting-state functional MRI data were used to compare the brain volume and seed-based functional connectivity, respectively. In statistical analysis, multivariate analysis of variance, with age and whole brain volume as covariates, was used to evaluate surface areas and subcortical volumes between the two groups.

Postmenopausal women showed significantly smaller cortical surface, especially in the left medial orbitofrontal cortex (mOFC), right superior temporal cortex, and right lateral orbitofrontal cortex, compared to premenopausal women (p < 0.05, Bonferroni-corrected) as well as significantly decreased functional connectivity between the left mOFC and the right thalamus was observed (p < 0.005, Monte-Carlo corrected). Although postmenopausal women did not show volume atrophy in the right thalamus, the volume of the right pulvinar anterior, which is one of the distinguished thalamic subnuclei, was significantly decreased (p < 0.05, Bonferroni-corrected).

Postmenopausal women showed significantly lower left mOFC, right lOFC, and right STC surface areas, reduced right PuA volume, and decreased left mOFC-right thalamus functional connectivity compared to premenopausal women. If replicated in an independent sample, these findings will be helpful for understanding the effects of menopause on the altered brain volume and functional connectivity in postmenopausal women.

Read the full study: DOI: https://doi.org/10.18632/aging.205662

Corresponding Author: Gwang-Woo Jeong - gwjeong@jnu.ac.kr

Keywords: brain morphology, functional connectivity, sex hormones, thalamic subnuclei

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About Aging:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimers diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as Aging (Albany NY)), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as AgingUS and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as Aging and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI

23-Mar-2024

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Altered brain morphology and functional connectivity in postmenopausal women - EurekAlert

Research Technician in the Center for Genomics and Systems Biology, Dr. Kristin Gunsalus job with NEW YORK … – Times Higher Education

Description

The Center for Genomics and Systems Biology (CGSB) at New York University Abu Dhabi (NYUAD) is seeking to appoint a full-time Research Technician in the Chemical and Functional Genomics Laboratory under the supervision of Professor Kristin Gunsalus.

The laboratorys research addresses emergent concerns that pose considerable threats to human health and the environment by investigating novel bioactive agents from microbial sources and chemical libraries. Research projects employ High-Throughput (HTP) screening of different biological organisms and High-Content Phenotypic profiling (HCP) of mammalian cells to provide bioactive candidates for the development of novel solutions for contemporary health and environmental challenges. The Research technician will have an integral role within the team providing technical support for operational and research activities. In this role, the key responsibilities of the candidate will include:

The ideal candidate will have a Masters degree in cell & molecular biology or microbiology with at least 3 years of experience in a research lab. The candidate is expected to have hands-on experience in microbiology, molecular biology, cell culture and cell-based assays, with a detailed mind for optimizing assays and generating quality data. Experience in analytical chemistry techniques and natural product extraction from microbes is highly desirable. Experience with high-content or high-throughput screening and lab automation is a plus. The research technician must have a strong work ethic, excellent organizational and communication skills with a high level of proficiency in English, and the ability to work effectively in a team within a multi-disciplinary environment.

The terms of employment include a highly competitive salary, housing allowance, and other benefits. To be considered, all applications must be submitted through Interfolio and should include a cover letter, curriculum vitae, a one-page summary of research accomplishments and interests, two recommendation letters, all in PDF format. If you have any questions, please send your inquiries atnyuad.cgsb.chemgen@nyu.edu

About the CGSB:

The Center for Genomics and Systems Biology (CGSB) at New York University Abu Dhabi was established to provide a nexus for cutting-edge life sciences research in the United Arab Emirates, with world-class facilities and resources to promote innovative advances in genomics and systems biology. The Center fosters and enhances the research and training missions of NYUAD, where undergraduate students, graduate students, and postdoctoral scientists engage in research across disciplines, facilitated by advanced instrumentation and computational support for high-throughput data collection, visualization, and analysis. The NYUAD-CGSB operates in partnership with its sister center, NYU Biologys CGSB, in New York, in an open organizational framework that enables transformative collaborative work across the globe supported by joint technology and service platforms.

About NYUAD:

NYU Abu Dhabi is a degree-granting research university with a fully integrated liberal arts and science undergraduate program in the Arts, Sciences, Social Sciences, Humanities, and Engineering. NYU Abu Dhabi, NYU New York, and NYU Shanghai, form the backbone of NYUs global network university, an interconnected network of portal campuses and academic centers across six continents that enable seamless international mobility of students and faculty in their pursuit of academic and scholarly activity. This global university represents a transformative shift in higher education, one in which the intellectual and creative endeavors of academia are shaped and examined through an international and multicultural perspective. As a major intellectual hub at the crossroads of the Arab world, NYUAD serves as a center for scholarly thought, advanced research, knowledge creation, and sharing, through its academic, research, and creative activities.

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UAE Nationals are encouraged to appl

Equal Employment Opportunity Statement

For people in the EU, click here for information on your privacy rights under GDPR:www.nyu.edu/it/gdpr

NYU is an equal opportunity employer committed to equity, diversity, and social inclusion.

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Research Technician in the Center for Genomics and Systems Biology, Dr. Kristin Gunsalus job with NEW YORK ... - Times Higher Education

Chordae Tendinea Rupture and Pulmonary Valve Vegetation in Pediatric Endocarditis: A Rare Condition – Cureus

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Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional. Infectious Disease Integrative/Complementary Medicine Internal Medicine Internal Medicine-Pediatrics Medical Education and Simulation Medical Physics Medical Student Nephrology Neurological Surgery Neurology Nuclear Medicine Nutrition Obstetrics and Gynecology Occupational Health Oncology Ophthalmology Optometry Oral Medicine Orthopaedics Osteopathic Medicine Otolaryngology Pain Management Palliative Care Pathology Pediatrics Pediatric Surgery Physical Medicine and Rehabilitation Plastic Surgery Podiatry Preventive Medicine Psychiatry Psychology Pulmonology Radiation Oncology Radiology Rheumatology Substance Use and Addiction Surgery Therapeutics Trauma Urology Miscellaneous

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Chordae Tendinea Rupture and Pulmonary Valve Vegetation in Pediatric Endocarditis: A Rare Condition - Cureus

Pruitt named director of academic pediatrics division Washington University School of Medicine in St. Louis – Washington University School of…

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Recognized for developing, leading growth of clinical programs

Cassandra M. Pruitt, MD, has been named director of the Division of Academic Pediatrics in the Department of Pediatrics at Washington University School of Medicine. A professor of pediatrics, Pruitt has served as interim director since July 2022.

Cassandra M. Pruitt, MD, a professor of pediatrics, has been named director of theDivision of Academic Pediatricsin theDepartment of Pediatrics at Washington University School of Medicine in St. Louis. She had served as interim director since July 2022.

The academic pediatrics division is home to the universitys Complex Care Clinic, which offers primary care to children with complex medical needs, and the General Academic Pediatrics Clinic, which provides a range of services, including well-child visits, immunizations and same-day visits for illness and other concerns. The division also offers physicians who specialize in developmental and behavioral pediatrics, which includes medical and psychosocial aspects; and physicians who specialize in pediatric physical medicine and rehabilitation, including musculoskeletal and neurologic conditions.

The division also houses the community pediatrics section, which provides a connection between community physicians to university specialists and St. Louis Childrens Hospital.

Beginning in 2019, Pruitt led the development and growth of the clinics and services in her role as medical director for the Complex Care Clinic and the General Academic Pediatrics Clinic. In her new role, Pruitt will continue to oversee development of the entire division in the Department of Pediatrics.

Dr. Pruitt brings a wealth of administrative, educational and clinical experience to this role, saidGary A. Silverman, MD, PhD, the Harriet B. Spoehrer Professor and head of the Department of Pediatrics. She is a dynamic leader who has already made significant contributions to the expansion and influence of the academic pediatrics division. With her extensive experience in leading the development of clinical programs, she is well-positioned to spearhead and propel the success of new initiatives.

A member of the School of Medicine faculty since 2010, Pruitt has worked as a pediatric hospitalist at St. Louis Childrens Hospital. As medical director for pediatrics at Progress West Hospital for eight years, she led the development of the pediatric hospitalist program and spearheaded improvements in clinical protocols and standardization of care for various medical conditions affecting newborns and patients being seen in the emergency room. She also has been a leader in quality-improvement projects with the American Academy of Pediatrics and the BJC HealthCare Center for Clinical Excellence.

In her role as vice chair of outpatient health in the Department of Pediatrics, she serves as medical director for Washington Universitys pediatric subspecialty clinical spaces. These include Memorial Hospital Shiloh in Shiloh, Ill.; Northwest HealthCare in Florissant, Mo.; and the Specialty Care Centers in west and south St. Louis County. She sees patients at St. Louis Childrens Hospital.

Pruitt earned her bachelors degree from Emory University in Atlanta and her medical degree from Texas Tech University Health Sciences Center School of Medicine in Lubbock, Texas. She completed her residency in pediatrics at the University of Texas Medical Branch Childrens Hospital in Galveston, Texas, where she also served as chief resident.

About Washington University School of Medicine

WashU Medicine is a global leader in academic medicine, including biomedical research, patient care and educational programs with 2,900 faculty. Its National Institutes of Health (NIH) research funding portfolio is the second largest among U.S. medical schools and has grown 56% in the last seven years. Together with institutional investment, WashU Medicine commits well over $1 billion annually to basic and clinical research innovation and training. Its faculty practice is consistently within the top five in the country, with more than 1,900 faculty physicians practicing at 130 locations and who are also the medical staffs of Barnes-Jewish and St. Louis Childrens hospitals of BJC HealthCare. WashU Medicine has a storied history in MD/PhD training, recently dedicated $100 million to scholarships and curriculum renewal for its medical students, and is home to top-notch training programs in every medical subspecialty as well as physical therapy, occupational therapy, and audiology and communications sciences.

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Researchers Show Injury Prevention Program Reduces Injuries in Young Children | Newsroom – UNC Health and UNC School of Medicine

The University of North Carolina at Chapel Hill was one of four academic medical centers on the study, which shows that an intervention program developed by the American Academy of Pediatrics can dramatically reduce injuries in young children.

CHAPEL HILL, N.C. Unintentional injuries are a leading cause of pain and death among young children. While injuries can range in severity from cuts and burns to drownings and poisonings clinicians agree that many are preventable.

A new study, led by researchers at Johns Hopkins Childrens Center and done in coordination with colleagues at four academic medical centers in the United States, shows that an intervention program developed by the American Academy of Pediatrics (AAP) can dramatically reduce injuries in young children. The findings were published April 1 in the journal Pediatrics.

This study shows that prevention counseling during regular checkups can play an important part in keeping young children safe and healthy, said Kori Flower, MD, MS, MPH, Division Chief and professor of general pediatrics and adolescent medicine at the UNC School of Medicine and a lead investigator at the research site at the University of North Carolina at Chapel Hill.

The Injury Prevention Program (TIPP) was developed by the AAP in 1983 and is used throughout the United States. The program provides pediatricians with guidelines on how to advise and educate parents about injury prevention, such as installing safety gates before children learn to walk to prevent falls.

While studies have shown that injury prevention programs can help parents gain knowledge and adopt safety practices, few studies have looked at whether this and other similar programs actually reduce injuries, as well as the type of injuries children experience or whether parents seek medical care.

To study TIPPs effectiveness, a research team led by Eliana Perrin, MD, MPH, the Bloomberg Distinguished Professor of Primary Care in the Department of Pediatrics at the Johns Hopkins University School of Medicine and School of Nursing, conducted a trial at four academic medical centers in the United States, including University of North Carolina at Chapel Hill, New York University/Bellevue Hospital Center, Vanderbilt University/Vanderbilt University Medical Center, and University of Miami/Jackson Memorial Medical Center.

At two of the centers, pediatrics residents were trained on TIPP and used the TIPP screening and counseling materials at all well-child checkups for patients from 2 to 24 months old. The two other centers did not use TIPP and instead implemented a separate, unrelated intervention program called the Greenlight Study. A total of 781 parent and infant pairs were enrolled in the study.

The majority of parents were Hispanic (51%) or Black (28%), and most were insured by Medicaid (87%).

Michael Steiner, MD, MPH, the Michael F. Durfee Distinguished Professor of Pediatrics and the Pediatrician in Chief at the UNC Childrens Hospital, made substantial contributions to the studys conception and design.

Researchers found that as children aged from 2 months to 24 months, the number of injuries reported also increased. For example, 9% of parents reported injuries since the last well-child check when their child was 6 months old, compared with 40% who reported injuries at 24 months.

The most common injuries reported were falls, other miscellaneous injuries, such as scratches, and burns. Injuries requiring medical attention also increased over the two years of life, but were only 16% of all reported injuries.

The findings also show that sites using TIPP reported significantly fewer injuries in young children with an estimated risk of reporting injuries across each of the well-child checkups of only 14% in the participants in the academic medical centers that used TIPP as opposed to more than double that (30%) in the control group. Researchers say their findings show that TIPP was able to significantly prevent injuries in young children, and that the benefits of TIPP improved as children got older.

From this large study, we learned that a relatively simple intervention in pediatric offices really helps parents keep their children safe, said Perrin, who was the first and corresponding author of the study. TIPP uses what we know about how children develop to tailor the advice we give to parents at each stage, and it works.

For media inquiries, contact Eliana Perrin, MD, MPH at (919) 593-2100.

Media contact:Kendall Daniels, Communications Specialist, UNC Health | UNC School of Medicine

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Provident Healthcare Partners Advises SouthernMED Pediatrics and Sweetgrass Pediatrics in a Partnership with U.S. … – PR Newswire

BOSTON and NEW YORK, April 4, 2024 /PRNewswire/ -- Provident Healthcare Partners("Provident"), a leading healthcare investment banking firm, announced it has advised SouthernMED Pediatrics ("SouthernMED") and Sweetgrass Pediatrics ("Sweetgrass") in a partnership with U.S. Pediatric Partners.

SouthernMED and Sweetgrass are two of the leading pediatric primary care providers in South Carolina and combined, one of the largest pediatric primary care platforms across the country. Together, their 90 providers extend services to 17 locations across 13 counties.

The professionalism and expertise of Provident guided us to a successful outcome.

This landmark transaction combines two clinically-driven organizations that are well-positioned to deliver high-quality pediatric care and capitalize on the robust value-based care environment across South Carolina.

Provident's deal team was led by Managing Director Craig Sager. Husch Blackwell served as legal counsel to Sweetgrass and SouthernMED, and Goodwin served as legal counsel to U.S. Pediatric Partners.

"When you start your company from nothing, you feel like you know everything about it, and certainly don't lack passion. However, when you start engaging in M&A discussions, it becomes crucial to have representation that not only helps you better understand your company, but also shares your level of passion. From the start, Provident placed us in the right rooms with the right people leading to the ideal partner to advance our company to the next level. We recommend Provident without hesitation to assist in taking the next steps for any healthcare organization," commented Dr. Kyle Guyton, Co-Founder and CFO of SouthernMED.

"We feel very fortunate to have navigated through this journey with Provident. We put our heart and soul into building our business from the ground up and entrusted Provident to negotiate on our behalf with an appreciation for this sentiment. The professionalism and expertise of Provident guided us to a successful outcome. We highly recommend the Provident Healthcare Partners team," stated Dr. Colleen Boylston, Founder and Clinical Manager of Sweetgrass.

"SouthernMED and Sweetgrass have longstanding reputations as high-quality pediatric providers across the fragmented market of South Carolina. Through this merger and expanded partnership with U.S. Pediatric Partners, both organizations are poised to extend their reach and amplify their mission, and we could not be happier for Dr. Guyton, Dr. Boylston, and their teams. They will be in good hands with U.S. Pediatric Partners," noted Sager.

About SouthernMED PediatricsSouthernMED is a leading pediatric primary care practice devoted to delivering compassionate healthcare services to children and young adults in South Carolina. Established in 2008 by Dr. Joseph Delaney and Dr. Kyle Guyton as a sole pediatric practice in Lexington, the company has flourished and expanded to 11 locations. For more information, visit https:// southernmedpeds.com.

About Sweetgrass PediatricsSweetgrass Pediatrics is a premier pediatric practice dedicated to providing comprehensive care for children and young adults in South Carolina. Sweetgrass Pediatrics offers convenient access to quality healthcare services across the greater Charleston area through six clinics. Established in 2002 by Dr. Colleen Boylston, Sweetgrass Pediatrics was founded with a mission to provide a comprehensive suite of pediatric health services to the communities it serves. For more information, visit https://sweetgrasspediatrics.com.

About U.S. Pediatric PartnersU.S. Pediatric Partners is a physician-led organization set out to form partnerships with the nation's leading pediatric practices. By bringing together passionate, forward-thinking clinicians, health groups, and strategic payor partnerships under innovative new care models, the company strives to make care accessible for all, encourage preventative medicine, decrease fragmentation, and improve quality of care. For more information, visit https://uspediatricpartners.com/.

About Provident Healthcare PartnersProvident is a leading healthcare investment banking firm specializing in merger and acquisition advisory, strategic planning, and capital formation services for healthcare companies. The firm has a comprehensive knowledge of market sectors and specialties, including primary care and pediatrics. Provident also has unsurpassed experience and insight into the M&A process, which includes working with a multitude of investors such as private equity firms and strategic consolidators. For additional information, visit http://www.providenthp.com or follow Provident on LinkedIn.

Contact: Provident Healthcare Partners Gina Casiello 877-742-9800 [emailprotected]

SOURCE Provident Healthcare Partners LLC

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Online child safety laws could help or hurt 2 pediatricians explain what’s likely to work and what isn’t – The Conversation

Society has a complicated relationship with adolescents. We want to protect them as children and yet launch them into adulthood. Adolescents face risks from testing out independence, navigating peer relationships, developing an identity and making mistakes in these processes.

Todays teens have new areas of risk and opportunity as they navigate the digital world, and this has led to debate over their social media use.

Concern about social media use by 13- to 17-year-olds has led to a patchwork of state initiatives as well as proposed federal legislation. Following the Surgeon Generals Advisory on Social Media and Youth Mental Health, issued on May 23, 2023, the Biden administration convened the Kids Online Health and Safety Task Force.

We are pediatricians who study child online behavior, and we are co-directors of the American Academy of Pediatrics Center of Excellence on Social Media and Youth Mental Health.

As we consider the role of the federal government in regulating teen social media use, we believe it is important to consider how to support adolescents drive for independence and social interactions, while protecting them from serious harm or having their identities commodified by powerful technology companies.

Without commenting on any specific piece of active legislation, here are the elements of any potential policy related to children and technology that we believe would be helpful, and those we are concerned could be harmful.

Key to any effective online child safety legislation is accountability, so that platforms are designed with the needs of children and adolescents in mind, rather than being driven by engagement and revenue goals.

Default privacy protections are also crucial. Young people often receive and dont want contact from unknown adults. These are typically marketers or random strangers, dubbed randos. Teens often teach each other ways to try to be safe, leading to widespread practices that may or may not be effective.

Methods for stopping online child sexual exploitation are not adequate, and elements of proposed legislation could help by limiting who can contact teens outside of their known social circles. Making young users accounts private by default would allow them to have online interactions just with friends and communities they seek out. Encouraging collaboration among technology platforms to flag social media users who pose a threat and identify problematic practices is also crucial.

Another helpful element of child online safety legislation is requiring better access to and control over platform settings. One challenge for social media users of all ages is to find and navigate the different available settings. These could be standardized to be readily accessible rather than requiring multiple clicks to find protections buried in an apps settings. Young people describe wanting more control in their platform use, including the ability to control their content, reset or update their algorithms, and delete data or accounts.

Prohibiting data collection from young people would also help. Behavioral data from digital breadcrumbs reveals a lot about users, which allows technology companies to sort them into categories to predict what they might buy or click on next. This practice is unethical because it can be used to exploit susceptibility to self-harm and low impulse control. It also is incompatible with the adolescent development ideal of exploration teens are supposed to test things out, push boundaries and change. Teens are harmed when apps and sites nudge them in particular directions in order to profit from them.

Legislation could also require technology companies to take user-reported problems more seriously. The companies could make clear the process for reporting problematic content or people, and what steps they will take after a report. Anecdotally, we have both heard in our pediatric clinical practices that teens dont make these reports because they dont trust that anything will happen in response. There are several possible approaches, including direct reporting to platforms as well as designating an intermediary to receive reports about problematic interactions on platforms.

Legislation could also focus on limiting the impact of misinformation. Misinformation is another problem teens encounter that is likely to grow with generative artificial intelligence. Platforms could mandate watermarking of AI-generated content. Platforms could also prevent the spread of untrustworthy content by identifying super-producers and applying rate limits so that they cant clog everyones feeds.

The federal government could also fund additional research. Despite the past decade of prolific social media research, there remains a lack of common data formats, metrics to measure key concepts, and interventions to promote well-being. Funding to support research, including projects that include investigators from government, academia and industry, should lead to progress and innovation in this area.

Finally, legislation could help advance age verification. To enhance protections for adolescents, platforms need to know if a user is a young person. Age assurance and age verification are complicated topics that researchers, policymakers and technology developers are studying to determine how to accomplish it without compromising privacy. One option could be a new setting that allows a device to indicate to platforms, browsers and apps what age range the user is in and implement age-appropriate protections for young users.

Requiring parent permissions would be harmful. This restrictive approach would limit access to safe places for many young people and exclude teens who are in unsupportive family settings. These approaches also put the burden on parents to be gatekeepers for every decision about platform access, which has the potential to increase family conflict.

Shutting down particular social media is also problematic. Singling out individual platforms does not address the systemic revenue-driven designs and business models that exist throughout the industry.

Thirteen is a common minimum age for social media platforms. Imposing age limits from 13 to 16 would also not be helpful. This proposal is not supported by clear evidence about what age range is best for all teens. It is developmentally appropriate for 13-year-olds to want to connect with their peers online.

Adolescents themselves support needing to meet developmental milestones to be allowed to use social media, and they acknowledge that individual teens may meet these at different ages. In other words, some teens have no problems at age 13, while others will continue to have problems with social media at age 17. Age restrictions may serve to distract from making sure platforms are following guidelines and best practices for all ages.

Young people often navigate online interaction with little help from adults. Theres a need for additional approaches to engage, educate and involve parents and other adults who work with and care for young people in supporting young people as they enter the online world.

There are numerous other critical areas of work, including bullying, mental health and parent burnout that need separate consideration. These areas are likely to need distinct policy approaches. But policy alone is not likely to solve all of these complex, intertwined issues that intersect in the digital world.

Legislation is a powerful approach to increase safety for young people online. It is important to recognize that teens themselves, as super-users in these spaces, have thoughtful ideas of their own about possible legislative and design elements to enhance their safety.

Families and adults who work with youth also need resources to better support adolescents. The Center of Excellence on Social Media and Youth Mental Health seeks to provide those resources through a Q&A portal, ongoing learning opportunities and resources.

Finally, adults must also be accountable for their own social media and technology use. Many teens report that parents social media use distracts from parent-child interaction and that adult social media use negatively affects them. To support young people, adults should model appropriate online behavior including being able to set their own phones down to be present for the critical, often tumultuous, yet amazing stage of their adolescents development.

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Online child safety laws could help or hurt 2 pediatricians explain what's likely to work and what isn't - The Conversation