All posts by medical

The anatomy of art – Otago Daily Times

A visit to the University of Otagos anatomy museum sealed a life-long interest in anatomy for Dunedin artist Nicola Jackson one that has reared its head for her latest exhibition, discovers Rebecca Fox.

Nicola Jackson suspects the work for her latest exhibition could be never-ending.

''I'm never going to be finished. I've done 45 masks; I'm at the point where what I've done is fine.''

Known for her bright colours, detailed drawings, papier-mache forms, and exploration of human anatomy, Jackson has incorporated all her trademarks into ''The Bloggs'', at Dunedin Public Art Gallery.

Her anatomy-related work began while studying at the University of Canterbury School of Fine Arts where her final-year project was the creation of an art anatomy room.

''I've just never stopped having that interest.''

A lecturer had sent her to visit the University of Otago's department of anatomy museum, where she became fascinated by the artfully produced historical anatomy illustrations and engravings. Although she drew the line at looking at disorder or illness.

''When I look back, what I really liked was the feeling of it [the museum], as much as any individual thing. I liked the atmosphere, the pot plants and the specimens mixed together, old and new.''

While she had always ''slipped anatomy in'' to her work, this was the first time since her student days she had focused an exhibition on it.

As part of that she wanted to re-create that ''feel'' of the anatomy museum so had collected a variety of ''old funny things'' such as old medical cases and glass display cabinets, which she has refurbished with colourful lashings of paint.

''It's been a slow accumulation.''

The exhibition's gallery has also been designed with that in mind, with the walls closer together and painted a dark orange.

''I wanted a small intimate room experience.

''It's an installation. I want people to experience the room as a whole, not necessarily looking at one work at a time.''

Jackson says she has a ''bee in her bonnet'' about the short amount of time people often spend looking at each piece in an exhibition.

''Making them be in a room, I hope they'll stop.''

Part of that means there will be no labels or titles for individual works in the exhibition unless written on the pieces themselves.

''I want people to wonder what it is.''

The title of the exhibition, ''The Bloggs'', also reflects that, as the artist wants it to reflect the possibility people were looking at any collection in any person's home.

Jackson herself likes the idea of collecting things but says finding the quirky in Dunedin is difficult.

''So I've had to make a papier-mache collection. If I see something I like, I think 'I'll have to make a papier-mache one'.''

Refurbishing the pieces of furniture is an important part of her work, she says. Re-upholstering an old sofa took a month, but she never considered outsourcing the work.

''There are quite a lot of menial tasks, but I like doing that sort of thing.''

Her papier-mache work is similar in the time it takes to create pieces.

''It can take six days once I get an idea, and I'll be day-dreaming away. There is always something to be done.''

The use of papier-mache also has an anatomical link as it was a traditional method for making anatomical models - a French company in particular developed a method for making the models that way.

''I like that connection. I had a holiday job as a student in a children's holiday programme and we all made lots of papier-mache - I'd never done it before, but realised you could make anything you like.''

Her creations - heads based on phrenology maps, masks and medicine bottles - are often made from the leftover rolls of newsprint from the Otago Daily Times and she finds using a layering method rather than pulp to be more successful.

However, to create her works she begins with modelling the idea in clay and then putting papier-mache over the top before pulling the cast off.

The process means having a ''production line'' of sorts where she is working on multiple pieces at once.

''It can be a tedious task. It might be a wee head-making factory for a month.''

She admits it is not what people might think an artist does.

Her passion for bright colours just came naturally, she says.

''I really don't know why. I love bright colours, I might be colour blind,'' she jokes.

Even at art school she gravitated towards bright colours.

''It pulls things together and they all relate to each other, they look like they belong together.''

The fine detailed drawings on the models and her paintings require a steady hand and more recently some clip-on magnifying glasses.

The best method for that kind of work was to draw boldly and with confidence, she says.

''I can't bring myself to loosen up. It's a style and I can't seem to do it any other way.''

Having filled her home studio with stacks of furniture and art, so much so she had to squeeze around it to be able to work, she is looking forward to seeing the walls again.

To see Nicola Jackson The Bloggs, Dunedin Public Art Gallery, March 18-June 5

See the original post:
The anatomy of art - Otago Daily Times

TV tonight: ‘Grey’s Anatomy,’ NCAA tournament starts – USA TODAY

Jesse Williams and Sarah Drew in ABC's 'Grey's Anatomy.'(Photo: Richard Cartwright, ABC)

NCAA Basketball Tournament CBS, 7 ET/4 PT

March Madness makes its 2017 primetime debut Thursday, taking over not just CBS, but TBS, TNT and TruTV. And if by some chance all that basketball isn't enough college athletics for you, the NCAA Wrestling Tournament is airing on ESPN. So theres pretty much something for everyone except, of course, for people who want to watch The Big Bang Theory and the rest of CBSs Thursday lineup, which is pre-empted.

USA TODAY

Ask our TV critic anything, get your answers on Facebook Live

Greys Anatomy ABC, 8 ET/PT

One fans blessing is another fans curse this week on Greys Anatomy. If you happen to be a fan of Jackson and April, youre in luck, as Thursdays episode is devoted to the sometimes couple, who travel to Montana to perform a complicated surgery on a young patient. And if youre not a fan? This would probably be a good week to explore other TV options.

Superstore NBC, 8 ET/PT

For example, if youre looking for something else to watch and you have fond memories of Ugly Betty, Superstore could be just the ticket, as its hosting a tiny Betty reunion. Tony Plana, who played Bettys dad, once again takes on a paternal role for America Ferrera, this time as Amys father. Turns out heneeds some help moving, and he gets it from Amy and Jonah.

Read or Share this story: http://usat.ly/2nuKwoS

Read this article:
TV tonight: 'Grey's Anatomy,' NCAA tournament starts - USA TODAY

What time is Grey’s Anatomy on ABC? – Radio Times

What time is Grey's Anatomy on ABC in America?

Grey's Anatomy is on ABC at 8pm (7pm Central time) on Thursday nights.

Who are the main actors in the cast and what characters do they play?

Ellen PompeoasMeredith Grey

Justin ChambersasAlex Karev

Chandra WilsonasMiranda Bailey

James Pickens, Jr.asRichard Webber

Kevin McKiddasOwen Hunt

Jessica CapshawasArizona Robbins

Sarah DrewasApril Kepner

Jesse WilliamsasJackson Avery

Jason GeorgeasBenjamin Warren

Caterina ScorsoneasAmelia Shepherd

Camilla LuddingtonasJo Wilson

Jerrika HintonasStephanie Edwards

Kelly McCrearyasMaggie Pierce

Giacomo GianniottiasAndrew DeLuca

Martin HendersonasNathan Riggs

Is the show made in Seattle?

Although Grey's Anatomy is set in Seattle, the majority of the programme is shot on six sound stages at Prospect Studios in Los Feliz, California to the east of Hollywood. A small number of exterior scenes are filmed in Seattle, but the majority take place on location in and around California.

How many seasons have there been?

ABC are currently airing the 13th season of Grey's Anatomy

Has Grey's Anatomy been renewed for a season 14?

Yes, the show has been renewed for another season by ABC expected later in 2017

See more here:
What time is Grey's Anatomy on ABC? - Radio Times

A new bill would allow employers to see your genetic information unless you pay a fine – Vox

A new bill is quietly making its way through Congress that could bring the US a little closer to a Gattaca-like future in which employers could discriminate against their employees based on their genes and risk of disease.

To understand how we might get to Gattaca, lets back up. Under Obamacare, employers are allowed to offer employees deep discounts on health insurance premiums if they participate in workplace wellness programs. The programs often involve medical questionnaires and health assessments which has meant employers can get access to some of their employees personal health data.

Employers embraced the wellness programs. Insurers love them. The Obamacare incentives helped grow the giant workplace wellness industry. And the workplace wellness provisions in the law were some of the only parts of the ACA that received enthusiastic bipartisan support.

Now this new bill, HR 1313 or the Preserving Employee Wellness Programs Act seeks to clarify exactly how much personal health data employers can ask their employees to disclose. And in doing so, the bill also opens the door to employers requesting information from personal genetics tests or family medical histories.

Unsurprisingly, HR 1313 has captured the medias imagination. Vanity Fair suggested the bill could make one sci-fi dystopia a reality. Fortune said workers might soon be forced into genetic tests. On NBCs Meet the Press yesterday, Health and Human Services Secretary Tom Price was asked about HR 1313 which is part of a set of bills that seek to replace pieces of Obamacare and said it sounded like there would be some significant concerns about it.

I reached out to two health law professors the University of Michigan Law Schools Nicholas Bagley and Washington and Lee University School of Laws Timothy Stoltzfus Jost for help parsing the legislation.

As it turns out, employee wellness programs were already very intrusive of employees privacy. It also turns out theyre a bit of a sham and dont work nearly as well as supporters might have hoped to make people healthier or bring down health care costs. But the new bill would allow employers to dig even deeper into participating employees personal health information. While employees wouldnt be forced to join the programs or hand over their genetic test results, theyd have to pay hefty penalties for opting out.

There are four main ways HR 1313 would allow workplaces to access more of their employees personal and family health histories, and potentially use that information to discriminate against their workers:

1) First, the bill would kill legal challenges over whether workplace wellness programs are actually voluntary.

Under Obamacare, people who joined employee wellness programs at work were sometimes asked to submit health assessments or questionnaires. Workers who participated were eligible for a 30 percent (or higher) discount on their health insurance premiums. Employees who didnt participate couldnt get that discount, and therefore paid more for their health insurance.

The health assessments or questionnaires might probe into peoples medical histories, and this created friction with laws such as the Americans With Disabilities Act (ADA). The ADA says employers cant ask their employees to undergo a medical history unless that request is made through a voluntary wellness program. And a 30 percent surcharge is a pretty large sum of money more than $5,400 for the average family plan in 2016 so opting out may not feel optional for many people.

To try and resolve this legal tension, the Equal Employment Opportunity Commission (EEOC), an independent agency involved with overseeing compliance of the AD, got involved in 2016. It determined that if the ACA allows this surcharge, then employers are in compliance with the ADA, meaning that its okay for employers to charge workers who dont opt in to the programs.

The legal ground for that ruling is shaky, according to Bagley, who blogged about the bill at the Incidental Economist. But the new bill would cement the EEOCs interpretation of this: Its also resolving in statute the tension between the ACA and ADA and Congress has never done that before. That means this provision of the ACA would no longer be subject to legal challenges in court, Bagley added.

And so under the new bill, if it passes, if an employer has a medial history questionnaire as part of a wellness program, a worker would need to choose between completing it and paying that surcharge.

2) Second, the bill would allow employers to ask about an employees family medical history or risk paying a surcharge.

Right now, under the Genetic Information Nondiscrimination Act (GINA), wellness programs cannot inquire about an employees family medical history. The reason for the prohibition is simple: If youre on a family plan, employers are helping subsidize all that costly medical care for your sick family members. If you might have a sicker-than-average family, your employer is not going to be too happy to keep you on, said Bagley.

Stoltzfus Jost explained: This keeps employers and insurers from discriminating against people with health problems or genetic predispositions. It also gives people the peace of mind of knowing their employer doesnt have that information.

The new bill would amend GINA and allow employers to start asking about family medical history for the first time. Those who refuse, again, would face that 30 percent surcharge.

So this also leaves employees in a tough spot. It means theyre now open to potential genetic discrimination by their employer or insurers. As Bagley wrote on his blog, Employers arent supposed to use that kind of information to discriminate against you. But theyll be sorely tempted: through your employer-sponsored coverage, theyre on the hook for your familys medical expenses.

3) Third, employers would be able to demand your personal genetic information unless you pay a surcharge.

Under GINA, employers only have the right to access anonymized aggregate data about their employees health thats collected as part of a wellness program. This was already controversial, since in workplaces with a small number of employers it might be easy for employers to tell which employees data they were looking at.

The new bill, once again, goes further: It says that if an employer runs a wellness program that complies with the ACA, then its okay to ask workers for their personal information. So this would mean employers could demand access to the results of genetic tests an employee might have undergone during pregnancy or to determine if shes susceptible to breast cancer, for example.

This, too, is not mandatory per se but if you refuse to give that information, you face that 30 percent surcharge. And again, theres that pesky discrimination problem. Employers aren't supposed to use sensitive information to discriminate, Bagley said, but the whole reason that statutes like the ADA and GINA keep that information from employers is because there's a risk that they may use it anyhow. In a worst-case scenario, for example, they could drop an employee who is at a high risk of a costly genetic disorder.

4) Fourth, the bill transfers more regulatory power from an independent committee to federal agencies

The EEOC is an independent agency involved with overseeing compliance of the ADA, and it also currently has regulatory authority over employee wellness programs.

The new bill would transfer regulatory power from the EEOC to agencies (HHS, Labor, and Treasury) headed by President Trumps Cabinet members.

This is a big shift of authority away from an independent agency that thinks a lot about discrimination to agencies that dont have the same mission and are more subject to the control of the president, said Bagley.

Wellness programs by their nature intruded on employee privacy. In the programs health assessments, they probed into how many hours workers slept, what food and alcohol they ate and drank, and how much they exercised. Thats part of the reason theyve been so controversial.

Many of the news stories on this bill suggest HR 1313 came out of thin air; it didnt. It simply builds on Obamacare provisions by clarifying exactly how much employers can peer into their employees health histories and genetic information and it empowers employers with even more oversight, leaving workers once again in the position of choosing between affordable health care and their privacy.

Employees in places with these wellness programs were already forced to make that choice; under HR 1313, theyll simply have even more to worry about, like whether they want their employer to see the results of a genetics test they had during a pregnancy, or to know that their spouse or mother had cancer or depression.

As Stoltzfus Jost of Lee University summed up, The bill expands or eliminates the employee protections that were pretty weak already.

This is worrisome for anyone concerned with genetic discrimination, genetic privacy, or disability rights, which is why groups like the American Society of Human Genetics have opposed the bill.

Meanwhile, theres actually no good evidence that these wellness programs actually do what theyre supposed to do improve health and bring down health care costs so employers fondness for the programs may be dissipating, Bagley added.

For now, HR 1313 has already been marked up by the House Education and the Workforce Committee, and its now up to House leadership to decide on when to vote on it. Hopefully lawmakers will pay attention to the privacy and discrimination issues and the lack of evidence for wellness programs as the bill moves through Congress.

Read this article:
A new bill would allow employers to see your genetic information unless you pay a fine - Vox

Why some Penn students decide to graduate in three years – The Daily Pennsylvanian

Students find that graduating in three years can lead to more opportunities for graduate school and career exploration | Courtesy of Alexia Tragakes (left), Gabrielle Jackson (middle) and Cheewin Kittikunapong (right)

College is often referred to as the best four years of your life. But some students choose to graduate after just three.

College junior Gabrielle Jackson will be graduating this spring, even though she entered Penn as a member of the Class of 2018.

Jackson decided to graduate early after the completion of her sophomore year.

I originally went into the advising office by the end of my sophomore year to look into graduating in three and a half years or maybe submatriculating into Penn Law School, she said. But when I went, I was told that I was too far along to submatriculate into Penn Law and also that instead of graduating in three and a half years, I could just graduate in three.

Instead of completing her senior year of college, Jackson plans on working full-time.

Right now my main focus is finding a job, she said. Im planning on working for a few years and then going to grad school.

The cost of going to Penn for another year as opposed to making money was a major factor, she added.

While Penn does not encourage students to graduate early, Jackson says the University was generally accommodating.

One of the things that I wanted to deal with graduating early was that I wanted to walk with my class with the Class of 2018 as opposed to the Class of 2017, she said. And they were really helpful in making that possible.

Im definitely going to miss out on some of the senior traditions and on another year with my friends who are mostly juniors, she acknowledged. But at the same time, I think Im ready to leave and move on and go to the next step.

Wharton junior Alexia Tragakes also plans to graduate early in order to attend law school. But unlike Jackson, she hopes to enroll in the fall instead of taking time off to work.

Before Penn, I knew that I might want to go to law school, and I came into Penn with a lot of credits, she said.

Most of these credits came from her International Baccalaureate program in high school, with others transferring from summer courses she took.

I think it was towards the end of my freshman year that I realized that with all the credits that I managed to get approved, it was attainable to graduate in three years, and I knew that I wanted to go to law school and that would be the next step, she said.

College junior Cheewin Kittikunapong is graduating early for a different reason: He wants to study internationally next year.

Kittikunapong wants to travel outside of the United States and determined that doing so would be difficult as an undergraduate.

Say I went abroad during my junior year. Id probably have to squeeze in a lot of course units by my fourth year, or else I would need to take an extra semester here, he said.

After squeezing all of his credits into three years, Kittikunapong will pursue his masters degree in Europe, ideally in the United Kingdom, he said.

Another motivating factor for Kittikunapong was his disappointment in Penns biotechnology resources.

Im studying biology right now, but then I hoped to go into biotechnology, and I felt that the biotechnology scene here isnt as great as I hoped it would be, he said.

He hopes to pursue his masters somewhere that offers more opportunities in the field.

Kittikunapong felt that graduating in three years was a smooth process, but it depends on the organization of the individual.

I planned it out really carefully, he said, noting that he made the decision in the middle of his sophomore year.

I was doing a second major biology and biochemistry but then my current major advisor in biochemistry was not having it. He wanted me to stay for the fourth year and do a senior thesis or something, so I just figured that if I dropped biochemistry and just did biology, Id be able to do just three years, so I did that instead.

Follow this link:
Why some Penn students decide to graduate in three years - The Daily Pennsylvanian

Grey’s Anatomy’s Big "Japril" Episode Just Might Be an Avery Family Reunion in Disguise – E! Online

For as long as he's been in our lives on Grey's Anatomy, Jackson Avery's father has never been in the picture.

We've gotten more than our fill of his mother, the domineering and ultra-successful Catherine Avery (Debbie Allen)especially with the mess she's created at Grey Sloan Memorial this year with the whole Minnick debaclebut we've never met the man who ran off when Jackson (Jesse Williams) was young, leavinghim to be raised by a single mother. But it looks like that all might be changingand soon.

In this sneak peek of Thursday's new episode, exclusive to E! News, Jackson and April (Sarah Drew) have traveled to Montana to treat a young patient, but when his ex-wife catches wise to what really may have brought them out to Big Sky Country, she's none too pleased.

"When are you gonna tell me that you found your father?" she unloads on her former spouse. "Your father, Jackson. Your long-lost deadbeat dad. The distinguished hippie former surgeon Dr. Avery who slings hash at the local diner. He's the whole reason we're here!"

"No, I came here to help a patient," Jackson replies, rather unconvincingly. Come on, Jackson! You're going to have to lie a little better than that.

The special episode, in which Williams and Drew are the only two series regulars to appear, is a sequel of sorts to the special season 12 episode that chronicled the pair's complete relationship history as they sign divorce papers amid April's secret secondpregnancy. Could what fans are affectionately referring to as "Japril: The Sequel" be the episode to bring these until as-of-late (thanks to Grey Sloan Memorial's ridiculous civil war) happy co-parents back together for good?

While the pair aren't spilling that precious detail under fear of retribution from their boss Shonda Rhimes, they did open up to E! News' Kristin Dos Santos about the episode."The relationshipWill they? Won't they? Are they going to stay together? They're co-parenting, being divorced, but living together. They can kind of escape through their work, but on this trip and in this episode, they're together," Williams teased during the recent TCA Winter Press Tour . "They have to face each other."

Are the actors themselves rooting for a reconciliation between their characters?"Yes, always. I'm just always rooting for them to get back together because they're great and I can't understand," Drew admitted. "There was stuff that made sense for them to be apart, but now it feels like that's in the pastJapril forever!"

Are you still holding out hope for Japril to get their act together and reconcile? Sound off in the comments below!

Grey's Anatomy airs Thursdays at 8 p.m. on ABC.

E! Online - Your source for entertainment news, celebrities, celeb news, and celebrity gossip. Check out the hottest fashion, photos, movies and TV shows!

More here:
Grey's Anatomy's Big "Japril" Episode Just Might Be an Avery Family Reunion in Disguise - E! Online

The anatomy of a high-potential’s benefits package – Human Resources Online

The value of a benefits package for high performers goes beyond monetary incentives. What else should HR pay attention to in order to keep them motivated and engaged at work?

Industry pros will examine the most critical compensation & benefits components at Employee Benefits Asia, the regions biggest conference dedicated to compensation & benefits strategy happening in Hong Kong on 11 May, Malaysia on 16-17 May, and Singapore on 18-19 May.

Stellar business results only happen when people are happy with their jobs and free from health issues and personal stress, said Aditi Sharma Kalra, regional editor of Human Resources magazine.

Employee Benefits Asia 2017 will thoroughly discuss the elements that keep top talent eager to grow and stay, such as work-life balance, recognition, and career progression, she added.

Employee Benefits Asia 2017 will discuss the most pressing issues being faced by C&B professionals according to the latest HR research and explore the impact of talent rewards on business transformation.

Here is how one of the topics, the framework of an effective benefits package, will be presented at the event:

A panel session entitled How do you package the benefits into a cutting-edge compensation & benefits programme that is competitive? will identify the key considerations when aligning benefits to wellness.

It will also touch on how wellness programmes complement benefits programmes in Asia and how the shift from treatment to prevention affects corporate culture. Jeremy Broome, regional head of human resources for Asia Pacific at Deutsche Bank, will be one of the panellists.

Additionally, the rationale behind flexible benefits will be scrutinised during the case study presentation entitled Adopting cost-effective flexible benefits without cutting corners. The speaker will reveal the challenges in implementation as well as their solutions, including key measurement of ROI and success factors.

Other topics that will be dealt with during panel discussions are the top benefits that are considered critical when recruiting and retaining talent and the different ways to cultivate employee satisfaction, from perks to career development opportunities.

Past Employee Benefits Asia attendees are top HR executives from leading and international companies in the region, such as CapitaLand, DHL, General Electric, Heineken, Maersk, The Waltz Disney Company, Rolls-Royce and many more. All presenters & panellists, such as Anita Zuo, HR director for rewards, recognition and HRIS at Electrolux, are director or vice president level HR professionals with regional responsibility.

Held in Hong Kong, Kuala Lumpur and Singapore in May 2017, Employee Benefits Asia is the regions biggest conference on compensation & benefits strategy. The event will unveil best practices and rewards strategies through an agenda dominated by case studies and global thought leaders and attracts a large audience of senior HR generalists and compensation & benefits specialists as well as and CEOs, CFOs and COOs closely involved in their companies compensation & benefits strategies.

To get a global and Pan-Asian regional view of compensation & benefits and expand your knowledge and skills across the rewards spectrum, reserve your seat for Employee Benefits Asia in May 2017.

To review the topics & agenda, check out http://www.employeebenefits.asia before its sold out. For more information please contact:

For Hong Kong: Francis Lee, regional producer, francisl@humanresourcesonline.net, +852 2861 1882 For Malaysia: Sammi Zhang, regional head of production, sammiz@humanresourcesonline.net, +65 6423 0329 For Singapore: Priya Veeriah, regional producer, priayv@humanresourcesonline.net, +65 6423 0329

Here is the original post:
The anatomy of a high-potential's benefits package - Human Resources Online

Team Develops More Effective Therapeutic Antibodies – Genetic Engineering & Biotechnology News

Researchers from the University of Maryland (UMD) and The Rockefeller University, who previously developed a method to modify an antibody's sugar group structure, which opened the door for biochemists to create antibodies with consistent sugar groups, report that they havetaken their method a step further by determining which specific sugar combinations enhance--or suppress--an antibody's ability to signal the immune system to attack an invader.

The results ("Modulating IgG Effector Function by Fc Glycan Engineering"),published online in the Proceedings of the National Academy of Sciences, are an important step toward the development of highly effective antibodies to fight cancer and other diseases, according to the investigators.

An antibody's ability to send killer signals depends on the configuration of sugar chains attached to the protein. In naturally occurring antibodies, these sugar chains have a lot of variability. Even in antibodies currently used for disease therapy, a given dose might contain a wide variety of antibody variants, also known as "glycoforms," distinguished by their sugar groups.

Although prior methods tried to sort out these glycoforms and collect the most effective ones, these methods are time consuming, expensive, and not 100% effective. The method used in the current study enables the researchers to create a given antibody with identical glycoforms using biochemical techniques. Each glycoform can then be tested independently to see whether it enhances or suppresses the immune response.

"Our first major step forward was to develop a method to produce homogeneous glycoforms," said Lai-Xi Wang, Ph.D., a professor of chemistry and biochemistry at UMD. "With this, we can now look at how individual different sugars affect the properties of antibodies. Until this study, we didn't have an efficient way to know how individual sugars in various glycoforms affect suppression or activation of the immune response."

Most therapeutic antibodies on the market are designed to treat cancer and autoimmune diseases. For example, rituximab is an antibody-based drug used to treat lymphoma, leukemia, and rheumatoid arthritis. Rituximab and other similar antibody drugs are usually produced in cultured cell lines.

"These processes are not optimized at all. There is no easy way to control glycosylation," noted Dr. Wang. Glycosylation is the process by which sugar groups are added to a protein such as an antibody. "Our method could be used to improve antibodies already on the market because it modifies the antibodies directly instead of working at the genetic level."

Dr. Wang's group, which specializes in the biochemistry of protein glycosylation, developed the methodology to modify the antibody sugar groups. They partnered with Jeffrey Ravetch, M.D., Ph.D., and his group at The Rockefeller University, which specializes in immunology and animal models, to test the effects of various glycoforms on the immune response. The new findings will help guide the development of future antibody-based therapeutics.

"Our method would be generally applicable because it can be used on a wide variety of antibodies," explained Dr. Wang. "It's an important step forward in the effort to engineer therapeutic antibodies that can target specific cancers, inflammation, and other diseases. Soon we will be able to build customized antibodies."

The rest is here:
Team Develops More Effective Therapeutic Antibodies - Genetic Engineering & Biotechnology News

SASSAgate: Anatomy of the Hidden Hand will all be revealed to ConCourt? – Daily Maverick

On Friday afternoon, in response to a PAIA application by DA Shadow Minister of Social Development, Bridget Masango, for information on any new contract between Sassa and CPS, the Department of Social Developments Deputy Information Officer, Michael Machuberg, responded, contract entered into between the department and/or Sassa with Net1/CPS for the distribution of social grants from 01 April 2017 does not exist and therefore not unavailable in our possession.

On March 6, however, Net1 CEO Serge Belamant in an interview with Radio 702 said that the previous week his company had agreed to a set of terms with Sassa on two very, very important issues, one of them were the commercial terms going forward, and the other set of terms is what we were going to do on behalf of Sassa in order for them to take in-house a number of technical processes we currently perform.

So, with only three weeks to go, the entire Sassa social grants crisis still appears to be in legal limbo.

Chief Justice Mogoeng Mogoeng last Wednesday directed Sassa to furnish, by 16:00 on Monday, full details of responsible officials, dates when these officials became aware that the time frames set out by the court could not be met, why the court had not been informed and whether Minister Dlamini had been informed, and if so, when.

Hopefully, whatever it is Sassa and the department and the minister submits to the court will unravel this very thickly woven knot of obfuscation, lies, deceit and delay tactics, and most important, why. Sassa officials and the minister, hopefully, will also answer why they secretly met with President Jacob Zumas lawyer Michael Hulley in December 2016 who then offered legal advice overruling that offered by Advocate Wim Trengove.

One of the officials who is likely to feature in the submission to the ConCourt is Zodwa Mvulane, Sassas Executive Manager, Special Projects. A batch of letters accompanying Belamants affidavit to the ConCourt on March 7 and in response to an application by the Black Sash gives some insight into the anatomy of the train smash.

Timeline and names of officials:

On May 24, 2016, Belamant wrote to Mvulane indicating that he had met with Sassa at your request a few months ago to discuss the implications for Sassa to achieve this objective [of taking the payment in-house]. We discussed both a closed loop system that could permit interoperability with the NPS [National Payments System], as well as an open loop system as is currently provided.

Belamant told Mvulane there is not enough time left between now on March 31, 2017 for the banks to assist in this massive task... As time is running out quite rapidly, it is critical for Sassa to decide on the way forward. In order to prevent disruption in the payment process and to protect beneficiaries, it may be better for Sassa to extend the current CPS contract for at least 12 months, during which Sassa could refine their strategy and implement a phase-out and phase-in plan.

On May 31 Advocate Nazeer Cassim and Mias Mostert advised Sassa that the Constitutional Court would have to be informed of the change in status pertaining to deliverables as well as the possibility of CPS tenure being extended. Meaning that by then Sassa had been aware that it was not going to meet the seven deliverables as set out by the ConCourt.

The court will be especially sensitive in our view to the continued involvement of CPS. Our concern is that the impression might be created that Sassa has all along been pulling the wool over the courts eyes. To prevent this impression from being created, our suggestion is that the change in proposed time frames relating to deliverables be coupled to new information emerging from the meeting with SARB... wrote Cassim and Mostert.

Presenting Sassas annual report to Parliaments portfolio committee on social development on October 13, 2016, where the closing balance of irregular expenditure was revealed as R1-billion and fruitless and wasteful expenditure as R10.9-million, the agency dedicated one paragraph to the institutionalisation of the payment system.

This is planned for implementation in four phases. Phase 0 was the Advisory Committee investigation that took place against the backdrop of the Cash Paymaster Services that ends in March 2017. Phase 1 will be led by Work Stream leaders appointed with the concurrence of the minister to guide the successful implementation of the recommendations of the Advisory Committee for the smooth transition of Sassa towards effectively and efficiently incorporating its payment role to the current in-house functions. Phase 2 and 3 entailing the transition and full roll-out respectively will be implemented during the period April 2017-March 2019.

It was at that presentation, made by then Acting Director-General of the DSD, Dr Wiseman Magasela, that the DAs Bridget Masango first raised the alarm saying that this was a huge project that needed to be undertaken by Sassa and which required a lot of preparation and that involved the lives of 17-million people who were dependent on social grants.

Where is the plan for this project and could the portfolio committee have access to it? Also was Sassa ready to take over the process? asked Masango.

The DAs Lindy Wilson also asked how far the agency was in terms of the seven deliverables as set out by the Constitutional Court.

According to the Parliamentary Monitoring Groups record of the presentation Magasela told the committee that Sassa was ready to give details or reach an agreement of when to come back to the committee to explain progress for the takeover and not withholding any information from the Committee.

Mr Magasela said Sassa was fully aware that the project was a huge one with responsibility in terms of making sure that social grants for 17-million south Africans were fully paid on time as had been the established practice. The Agency was working towards making sure that come March 2017 all south Africans would receive their grants. The Minister was providing political leadership on the issue. There was also a project manager managing this project.

On October 19 the portfolio committee met again to review and adopt the DSD budget and recommendations report. Once again members asked about the progress for Sassas takeover of grant payments.

On November 16 a meeting had been planned for Sassa to brief the portfolio committee but was cancelled at short notice and replaced by a presentation by the National Development Agency.

The minutes read: Members objecting pointed out that the Sassa briefing had been agreed upon as far back as 13 October and had been placed on the agenda following an agreement by the chairperson as far back as June that the plan would be presented to the committee. There was a suggestion that the chairperson had deliberately tried to prevent the presentation, but the chairperson explained that this had in fact happened firstly because the Minister, who wanted to accompany the Sassa delegation, was out of the country, and secondly because Sassa would be meeting with stakeholders prior to coming to brief the committee.

On November 30 Minister Dlamini and Sassa returned to Parliament to brief the committee with regard to Sassas readiness to take over as paymaster for the grants. Present along with Dlamini was the newly-appointed Director-General of the Department of Social Development, Zane Dangor, as well as newly appointed CEO Thokozani Magwaza. At that meeting opposition as well as ANC members complained that the department had not sent the presentation document earlier so that members could read and interrogate it.

At that meeting Magwaza told members that Sassa was ready for the takeover from April 1.

However, SASSA through the minister asked that the committee does not push it to reveal its contingency plans in public as this might jeopardise the work it has done already. What matters is that by 1 April 2017, the grant will be paid. (our italics)

Sassas Executive Manager, Raphaahle Ramokgopa, at that meeting said that Sassa had fulfilled its obligations to the Constitutional Court which had assumed a supervisory role over the agency after the 2012 contract with CPS had been declared irregular. The first report, she said had been about the fresh tender application, the second dealing with progress towards implementation of the tender, the third with the outcome of the tender process and the fourth with the implementation process within Sassa.

Ramokgopa admitted that there are areas where Sassa was not meeting deadlines and that the agency had sought a legal opinion.

With the feedback received from legal counsel and other people, Sassa will go back to explain to the court what had happened, the work in progress and the mechanism in place for implementation, said Ramokgopa.

At this presentation is appears as if Ramokgopa parrots some of the content of Belamants May 24 letter to Mvulane.

Heres Ramokgopa on November 30; There are two options. The first is an open architecture or open loop. This involves operating in the national payment system that is provided for by the Reserve Bank. The second option looks into a combination of both an open and closed loop system. Both options specify the need for Sassa account requirements which Sassa has done an expression of interest for. Sassa is also in discussion with the Reserve Bank, PASA and BASA on a specialised account which has limited facilities... The open loop is a system operating in the national payment system, the accounts are fully accessible and allow direct reconciliation. Biometrics is a key factor in both options. In the current payment, the Reserve Bank has given permission to Sassa to utilise biometrics for older people and disabled persons. Discussions are on the way as to whether this can be extended to all beneficiaries. The reason for the need for biometrics is for fraud and risk management. Option 1 requires a new Sassa card that operates in both a closed and open system. It must be an integrated system flexible enough to operate in both and allow cash disbursement for beneficiaries in remote areas. Generally, for both options Sassa needs to develop an internal ICT system, recruit relevant capacity and use a phase in and phase out approach.

Heres Belamant to Mvulane on May 24; We discussed both a closed loop system that could permit interoperability with the NPS, as well as an open loop system as is currently provided. The reason for the two approaches which are both technologically equivalent in terms of interoperability, is that a closed loop system would allow Sassa to provide a payment solution which would be under its control in totality as Sassa would operate only under the Social Assistance Act of 2004. An open system would require Sassa to obtain or make use of a banking licence, amongst others, or to outsource this function to one or more banks resulting in a solution similar to the current system. The open loop payment solution would be governed by the banking rules, the SARB. PASA Visa and MasterCard, the FSB, etc. and, as such, Sassa would not have actually taken the payment function in house in any way but simply outsourced it to a different bank or/and service provider which would probably require a fresh tender to be issued.

At that meeting the DAs Wilson asked whether Sassa had accomplished the ConCourts seven deliverables as well as Who is the supervisor now? Was the court informed when the deliverables were changed? Have the deliverables been extended especially once the deadline for a deliverable has passed? Was the Constitutional Court informed about it and what was the decision?

To which Dangor replied that the fact that some of the timelines have not been met means that Sassa has to go back to the Constitutional Court to discuss the options. The Constitutional Court is the supervisor.

Zodwa Mvulane replied that when Sassa began to solicit advice from other stakeholders as well as reports from the work streams it became apparent that Sassa had been overly ambitious about some of its timelines.

Hence Sassa took the advice and broke down the deliverables and start working on things that matter.

Minister Dlamini then suggested the committee invite officials from Treasury, the Reserve Bank, the Post Office and Postbank so that members could have a clear understanding of what is going on.

However, added Dlamini, there are challenges Sassa cannot talk about.

Back now to Belamant waiting in the wings.

On December 9, 2016 Belamant wrote to Dlamini expressing that he was becoming increasingly concerned with the lack of communication from Sassa and that CPS would also commence the dismantling of its payment infrastructure on January 1, 2017.

Belamant told Dlamini As you are aware, on November 30, 2016, Sassa reported to Parliament that it would be ready to perform the payment of all social grants by April 1, 2017. The Contract and Service Level Agreement (the contracts) between Sassa and Cash Paymaster Services (Pty) Ltd (CPS) were declared invalid by the Constitutional Court of South Africa. The Constitutional Court, however, suspended the declaration of invalidity until a) Sassa issued and awarded a fresh tender or b) until March 31 , 2017 which ever event occurred first.

He added that over the past six months (so at least from August) the SARB, PASA, Grindrod bank and MasterCard have engaged with us to debate the technological issues related to the longevity of the existing Sassa branded cards and if a solution could be found to prolong their lifespan beyond April 1, 2017. He added that these stakeholders were of the view that finding a solution was primordial as Sassa had not finalised or disclosed their transition plan, but that such plan would undoubtedly require the Sassa branded cards to continue to operate beyond April 1, 2017 to ensure that there would be no disruption to the payment of grants service going forward.

And then As a result, we have developed and tested a plan that will ensure continuity but such plan requires your urgent endorsement and commitment.

On December 18 the Sunday Times reported that Minister Dlamini, Dangor, Magwaza, Mvulane and Ramokgopa had met with President Zumas lawyer, Michael Hulley, at the Intercontinental Hotel at OR International Airport. Dlamini had summoned the officials and Hulley had arrived out of the blue.

Dangor and Magwaza reportedly expressed at the meeting their serious concerns with the meddling of Hulley in the matter and also quizzed his role in the matter.

On December 22 Sassas Mvulane responded to CPS saying that it was willing to engage on probabilities for assistance in the transition of Sassa operations towards a new service model, and suggested a first meeting on January 5, 2017.

On December 30 Dlamini chaired a meeting with Sassa CEO, Magwaza, Mvulane, Dlaminis special adviser, Sipho Shezi, DSD deputy director-general Brenton van Vrede, Sassas legal consultant Tim Sukazi, Ramokgopa as well as head of corporate services, Dumisani Ndlovu, at President Zumas lawyer Michael Hulleys office in Durban. There they discussed the CPS contract.

Dangor reportedly refused to attend this meeting.

On February 1 Sassa was back in Parliament for a briefing with the committee, a meeting Dlamini skipped, opting to attend a Cabinet lekgotla instead. Opposition members refused to accept her apology and also complained once again about the late circulation of material to be presented.

ANC committee member Hope Malgas rebuked opposition members saying the lekgotla was important and warranted the postponement of meetings.

There is nothing wrong in postponing. The ANC being in government has to give guidance, said Malgas.

Ramokgopa set out six options including retaining CPS (only snag being the extension of the illegal contract), procuring the services of banks [Treasurys suggestion] while this option may guarantee service delivery, there is no guarantee that beneficiaries will be paid who are at the cash pay point, procuring the services of banks and the setting up of a special account [a plan that needed six months], option four using banks for some payouts and CPS for cash pay points, using SAPO and the appointment of a service provider for cash distribution and for banked beneficiaries to use existing accounts.

Given the above circumstances, Sassa came to the conclusion that it has failed. Sassa is of the view that Option 1 carries the least risk in terms of service delivery failure and as such should pursue the option while working on Option 6. In order to pursue this option, Sassa will approach Constitutional Court as a matter of urgency, since this is likely to be virtually the only mechanism to regularise such an approach which would otherwise be irregular. Also procurement in relation to Treasury practice Note 3 of 2016/17 will need to be followed.

It was at this meeting that Magwaza let slip with regard to the fact that Sassas selection of option 1, to go with CPS, had not yet approached the Constitutional Court but that the lawyers have assured Sassa that the court will approve since it is a matter of national emergency.

Which lawyers Magwaza did not disclose.

Was this Hulleys advice?

The ConCourt will soon find out.

On February 2 the Minister of Finance wrote to Dlamini informing her that continuing a contract with CPS would expose government to legal challenges. He proposed that a tender be given to banks and the Post Office.

Sassa revealed what everyone keenly watching developments feared, and suspected: that it was nowhere near ready to assume the critical function and had, in fact, not fulfilled even a single one out of the seven deliverables set out by the Constitutional Court.

If you ask me to choose between irregular [processes] and the country going up in flames, I choose irregular, Thokozani Magwaza told the committee to some audible gasps in the room.

9 February Magwaza wrote to Belamant with regard to exploratory discussions.

16 February Belamant replied to Magwaza stating we have... not received any formal notification from Sassa or yourself regarding the dates for such exploratory discussions. I am concerned that any further delay will significantly impact on our ability to conclude an interim arrangement. It is our view that any negotiations in this respect will require adequate time and consultation to address the following aspects of a new contract. including but not limited to duration, price, phase-in or phase-out strategy, BEE.

Belamant added that it is unlikely that the current contract can be extended due to the Constitutional Court judgment as well as the legal constraints of the PFMA. An extension of the contract would, in any case, be unacceptable to the Net1 board of directors due to the ongoing controversy and reputational damage to our company. I have rescheduled my diary as well as my travel arrangements to accommodate the Sassa meetings and will be available to meet with you from 1 March 2017.

On February 22 the portfolio committee met again. This time the panic was even palpable in the minutes published later by PMG. Dlamini, with CEO Magwaza wiping his brow frequently, dominated the meeting, seldom allowing Sassa officials to speak.

It was the IPFs Liezl Van Der Merwe at the meeting who asked, Can you confirm they [CPS] are seeking an extra R1.3-billion from this department to pay out the social grants? I also want to know that you dont want to pass the buck to Treasury but there are allegations that come March 31 and there is a problem of some sorts you will pass the buck and blame Minister Pravin Gordhan which will give the minister and the president more ammunition to fire Pravin Gordhan.

Committee chair Rose Capa accused the media of terrorising the poor.

On February 28 Sassa appeared before Scopa to account for the mess. It was learned that Magwaza had been booked of ill with high blood pressure and that CEO of the National Development Agency, Thamo Mzobe, had been appointed that morning as acting CEO, and who became ill a week later. Dlamini opted to skip this Scopa meeting, which angered members. It was a shambolic presentation. Members called for Dlamini to account to Scopa.

That same day Sassa filed papers with the Constitutional Court asking it to authorise its engagement with CPS for 12 months from April 1, 2017 to March 30, 2018. Twenty-four hours later Sassa withdrew the application on orders from the minister. Mzobe, who was still on the job at that point, said that Sassa had not been consulted by Magwaza and were now merely sending a follow-up report to the court.

On the same day, the Black Sash filed with the Constitutional Court asking it to act in a supervisory role with regard to the new CPS contract. In court papers the Sash says Sassa breached its constitutional obligations of transparency and accountability to the public to Parliament and to the court.

March 2, 2017 Dlamini and Sassa filed the follow-up report with the ConCourt accepting responsibility for the fiasco.

The minister and Sassa accept responsibility for Sassas inability to deliver the system deliverables set out in the progress report, reads their submission.

Sassa also claimed it only became aware in August and October 2016 after advice from technical advisers that it would be unable to take the payment of social grants in house after March 31. Sassa added it was not ready to move forward due to budget constraints, insufficient internal capacity and a lack of skilled personnel to implement the plan in the time frame it had contemplated.

March 3, 2017 DSD DG Zane Dangor resigned citing a breakdown in the relationship with the minister.

March 5, President Zuma met with Dlamini and Gordhan and said the Sassa crisis is solvable.

March 5 Dlamini and her spokesperson Lumka Oliphant called a last-minute press conference which ended up with Dlamini refusing to answer questions from journalists. Dlamini blamed the media for creating panic with regard to the payment of grants on April 1. Dlamini confirmed, however, that no deal with CPS had been signed, contradicting an earlier statement that a deal had in fact been concluded.

March 7 Minister Dlamini appeared before Scopa and received a grilling of note. She told committee members that Scopa had underestimated the amount of work.

March 8 The Chief Justice Mogoeng Mogoeng directed Sassa to reply in detail questions relating to responsible officials, a time line for the fiasco as well as when it was the minister was informed.

March 14 4pm Will all be revealed? DM

Photo: Minister of Social Development Bathabile Dlamini closes the National Youth Camp at 3 South African Infantry Battalion near Kimberley, Northern Cape, 12 December 2016. (Photo: GCIS)

The rest is here:
SASSAgate: Anatomy of the Hidden Hand will all be revealed to ConCourt? - Daily Maverick

‘Grey’s Anatomy’ recap: ‘Civil War’ – EW.com

Meredith whos baaack opens the episode talking about a father who sent both of his sons to fight on either side of the Civil War, an apt story considering almost everyone in the hospital is in a small, personal war against at least one or two of their colleagues. (Though considering the episode is titled Civil War, Im not sure what else we could expect.)

That said, here is how the battle lines were drawn:

Catherine vs. Richard

The Chief is sleeping in the hospitals on-call rooms, which prompts him to request that Bailey replace all the mattresses with something that provides lumbar support. But the bigger issue, of course, is that he feels that the longer Minnick stays, the more the other members of the hospital staff will grow to love him something Arizona tries to talk him out of.

However, Richard cant keep ignoring Catherine who suggested he can come sleep at home forever, as theyre both operating on the same patient, a man whos been in a deep fryer-related accident courtesy of his friends boyfriend. Of course part of this is Richards annoyance that Catherine would dare to watch Hamilton in Chicago without him.

Later in the night, Richard asks Arizona if he can stay with her, but she mentions her date (not telling him its actually with Minnick), so he decides to pull an all-nighter at the hospital instead. Only the patient gets into trouble and needs to be operated on, but when all the doctors get in, Ben is already operating on him. Catherine tells Richard to step in, but he says that Jacksons got it.

After the surgery, Jackson gets mad at Richard for basically using Minnicks method, but the former Chief points out that he was teaching the way hes always taught; its just that Ben is a very capable second year resident. He also doesnt want to tear mother and son apart, especially seeing the younger Avery rail against Catherine this entire episode. But Jackson just responds that his mother wont stop because she wants things her way.

Later, Richard walks in on Arizona and Minnick as theyre about to kiss, following a long night where they just slept on a hospital couch instead of going back to Arizonas place, where Minnick was going to make her pierogies. As he apologizes and leaves, Richard shoots Arizona a hurt look, and its clear that she too feels awful.

Back in an on-call room, Catherine asks Richard to come home and get a good night of sleep. He tells her he didnt want to come between her and Jackson. He then sleeps in the on-call room. She wishes him a good night and leaves.

Jackson vs. Catherine and April

Jackson blames this whole thing on his mother, and he sees April, who is frustrated by having to give Meredith her job back, as a traitor. First he goes and tells his mom that as the Avery Foundation representative on the hospitals board, hes going over her head, then hes very short with her as they attempt to work on the groups trauma patient.

It doesnt help matters that Catherine, who feels April has earned her position and is proud of her work, is planning to take the trauma surgeon to Chicago with her so the Avery Foundation hospital doctors there can learn from her. (They also plan on seeing Hamiltonand going on a boat tour, which Ben says is lovely. So, you know, theres that.)

NEXT: Jacksons anger continues, And its Alex vs. Riggs

Follow this link:
'Grey's Anatomy' recap: 'Civil War' - EW.com