All posts by medical

Abortion is really settled science — Robert Rittmann – Madison.com

After 44 years and more than 58 million aborted babies, I don't know how anyone can continue to ignore the March For Life.

I don't know how anyone can ignore the science of an ultrasound picture and deny that it is a baby in the womb. Children are not like bad teeth one yanks out because they produce pain or are inconvenient.

In this day and age, if you are educated in basic science, you must reject abortion on the basis that all individual citizens are equal, and the freedom of choice is for choices that do not hurt or exterminate other human individuals.

Science shows the baby has separate DNA that is different from the mother's. The new human has a genetic composition that is absolutely unique, different from any other human that has ever existed, including that of his or her mother. You can find this information in any basic textbook of embryology.

Scientist don't argue against this.

Unlike climate change, this really is settled science. We all have an unalienable right to life, liberty and the pursuit of happiness.

Robert Rittmann, Sun Prairie

Read the original:
Abortion is really settled science -- Robert Rittmann - Madison.com

Biochemistry professor continues to follow passions at 100 years old – The Maneater

Eighty years ago, professor emeritus of biochemistry Boyd ODell began taking classes at MU. Now 100 years old, ODell, who has made many discoveries and inspired generations of colleagues, can still be found in his office in Eckles Hall.

I have some questions I really would like to answer, and Id rather think about answering those questions than retiring, ODell said.

ODell technically retired in 1988, but still does part-time research on campus.

In September, a celebration honoring the 40th anniversary of the biochemistry department served as an early 100th birthday party for ODell. In December, a plaque was unveiled, naming the bridge connecting Schweitzer Hall to the Schlundt Annex the Boyd ODell Bridge of Discovery.

I hope the bridge will be a bridge to the future for all the students and progress will be made in research and learning, ODell said at the unveiling.

Over the years, ODell has served as a mentor and a friend for many of his colleagues and students. Biochemistry professor Judy Wall first met ODell when she joined the MU faculty in 1978.

Hes an incredible gentleman, very professional, a great scholar and a truly kind person, Wall said.

Wall remembers when she and ODell were assigned to evaluate a graduate students grant proposal for a comprehensive exam. This was Walls first time evaluating this type of exam, and the only other female faculty member in the department did not attend their presentations.

I was the sole female faculty member and, you know, a silly person who was in the process of thinking about impressing all of my peers and making sure they didnt think I was an idiot at the evaluations, Wall said. So I was all set for getting this guy because I didnt think his proposal was great.

ODell went first. He discussed the importance of the problem the student had addressed and the strengths of the work before introducing criticism.

That was a wonderful experience for me because I thought thats exactly the way you should do it, Wall said. You have to earn the right to criticize by showing that you understand whats going on and you have to earn the right to begin to make constructive suggestions. Dr. ODell had shown me that was the professional way of going about it.

Wall uses this same approach anytime she has to evaluate anything in a similar manner.

He didnt realize, and I dont think I realized at the time, that he was mentoring me, but he certainly was, Wall said.

ODell decided to pursue education because he admired his teachers, who were his first role models.

I always had an ambition to be a teacher, ODell said. What did a farm boy in Carroll County have as role models? There was two things that I can think of, teacher was the most obvious one, and veterinarian.

ODell was born on a farm outside of Hale, Missouri, on Oct. 14, 1916. Becoming a veterinarian wasnt an option he considered, because it wasnt a financial possibility.

My parents were just poor farmers, and they couldnt help me, he said. I had to pave my way.

The summer after he graduated high school, ODell took an examination to become a teacher.

I passed all subjects with high scores except one, and that was pedagogy, ODell said. I didnt even know what pedagogy was. I suppose its the art of teaching.

That summer, ODell took classes at the University of Central Missouri, which was known as Warrensburg Teachers College at the time. He then began working in a one-room schoolhouse, where he taught first through eighth grade.

It was kind of fun in retrospect, ODell said. And that was in the depths of the Depression, to be paid $50 a month was a very good job. A lot of people were unable to even find a job.

Because he wanted to continue his education, ODell left the grade school after four years.

After a few years I transferred to the university here and got jobs one way or another and was able to support myself, he said.

He wanted to study bacteriology, but MU didnt have a program, so ODell was advised to become a chemistry major.

I worked for Dr. A.G. Hogan, who was my mentor for my Ph.D. At that time, he was interested in a vitamin that now is known as folic acid, ODell said.

ODell went on to work for a pharmaceutical company in Detroit after receiving his degree. With the end of World War II, MU saw an increase in students and invited ODell back to become a professor.

Coming back to Mizzou was kind of an easy choice because that was home. Im a Missourian through and through, ODell said.

ODell then studied the existence of unknown vitamins as an assistant professor.

At that time, an assistant professor was really an assistant to the professor, ODell said. When I became a little further along and had the independence, I still followed the question of, are there still unknown vitamins?

ODell went on to study the role of copper and zinc in the body. Among his discoveries was the revelation that copper deficiencies in animals can cause death through the rupture of the aorta, in the heart.

The opportunity arose for me to go on a sabbatical to Australia, ODell said. And why would I want to go to Australia? If youre interested in copper, its the place to go because much of the soil in Australia is copper-deficient.

In Australia, ODell saw that copper deficiency in sheep can cause symptoms similar to Parkinsons disease. He later observed the same results in rats.

We became interested in zinc deficiency around the same time, ODell said. We found that zinc deficiency in animals stops growth and causes increased subject to disease. Diarrhea is a common complaint of zinc-deficient animals and children.

He then discovered that phytic acid, which appears in plants such as soybeans and corn, can actually impact the way the body absorbs zinc.

Scientists want to know why does zinc deficiency cause these signs and symptoms in humans and animals, ODell said. Ive been interested in trying to solve that question for quite a number of years.

ODell is currently researching the importance of zinc in maintaining calcium channels.

If you think back of all the factors that a cell does, a cell divides, a cell secretes, contracts and carries messages, ODell said. All of this is dependent on a calcium channel, and if you take away zinc, the channel fails and you get all these symptoms. I think that that is the true, fundamental function of zinc to maintain the calcium channel.

ODell and Wall, a professor of biochemistry, have since worked together on a variety of committees and both taught biochemistry to first-year medical students.

He was always incredibly prepared, just beautiful lectures and so absolutely timely, Wall said. He knew the literature and was just great.

Another of ODells colleagues, professor emerita of biochemistry Grace Sun, also spoke of ODells role as a mentor.

Right now, Ive been retired for two years only and hes been retired for many more years, Sun said. I would say that hes a role model for me, and I wish I could do half as much like him.

The two became friends in the 80s, when a colleague Sun had met while working as a visiting professor in Taiwan came to MU to study with ODell.

ODell and his wife used to throw parties around the holidays where they would serve American foods, Sun said.

We loved it because we have a lot of international students and he has always a group of them, Sun said. At the time, he was like a hub for the international students.

Sun says ODell still interacts with colleagues and former research assistants by attending seminars and events on campus.

I remember one time, this must have been four or five years ago, and hes way over 90 and he wrote me an email, Sun said. He read a paper and then he said, Hey, Grace, maybe we can work together to do something on this area. I was so shocked. I was really amazed how he must be reading a lot of papers at home or in his office.

Now, ODell does experiments once or twice a week with cells that are grown in the Life Science Building.

I asked to use the equipment and I think they decided they better volunteer to do some of the work rather than trust me, ODell said with a laugh.

An undergraduate was assigned to help ODell grow and transfer the cells, Wall said.

It came holiday time, and the undergraduate was coming up on holiday, and so instead of imposing on this woman, Boyd decided he would just teach himself how to culture the human tissue culture, and so he did it, Wall said. Every day he would come over and transfer his cells and work with his cells. He walks over form Eckles to the Life Sciences Center and back again and has learned how to do this. What a terrifically fearless person he is when it comes to science.

ODell doesnt just walk across campus; he also walks from his house every time he comes to do research.

Most of my career I rode a bicycle to work, ODell said. I dont have a car, and I dont ride my bicycle anymore that leaves walking. I like walking. I think its good exercise, and I need exercise.

ODells daughter Ann, who lives in Columbia, helps drive him when he needs to go shopping and eats with him every week. ODell has a son, David, who lives in California, as well as four grandchildren and two great-grandchildren.

Outside of science, ODells hobbies include photography and bird-watching.

I was always interested in bird-watching and nature work; I guess that might fall from the science, ODell said. Even when I was teaching at the grade school, I had projects for the kids where wed collect plants.

After 100 years, ODell recognizes the importance of lifelong learning and following ones interests.

I think you should, in general even beyond science, you should pick a job or do what you have a real passion for, ODell said. I think if you really are keenly interested in it you will be successful.

Edited by Kyle LaHucik | klahucik@themaneater.com

Go here to read the rest:
Biochemistry professor continues to follow passions at 100 years old - The Maneater

Sumo protein explored as likely source for some congenital heart defects – Medical Xpress

February 7, 2017 by Brandi Klingerman Professor Paul Huber. Credit: University of Notre Dame

Small ubiquitin-like modifier (SUMO) proteins are small peptides that get added on to other proteins to regulate their activity. While SUMO has many regulatory roles in cells, it is especially important for controlling gene expression during early development. Just a few years ago this connection between SUMO and gene regulation was relatively unknown, but now, Notre Dame researchers are exploring how a disruption to the SUMO protein's ability to regulate embryo development may be linked to congenital heart defects.

Paul Huber, professor of chemistry and biochemistry, and Norman Dovichi, the Grace-Rupley Professor of Chemistry and Biochemistry, are working together to understand the role of all proteins in embryo development using Xenopus laevis or the African claw frog. This species is known for having a similar gene structure to that of the human genome, meaning that findings related to this species have the potential to provide a deep understanding about human diseases.

When discussing their research, Dovichi said, "In 2014, Huber and I completed a study using Xenopus laevis embryos to understand how more than 4,000 proteins fluctuate during the different stages of development. We found that certain proteins spike or lower during specific stages. For example, a number of proteins that are used during the creation of cardiovascular tissue rose during stage 13, when organs develop."

In these early experiments, Huber found that when SUMO activity was repressed, many of the embryos had two predominate phenotypes, one of which was heart defects. Then, new studies began linking mutations in SUMO protein to heart failure as well as congenital heart defects. This is when the Notre Dame researchers began to develop the next steps for their research.

"At the time, there was not a lot of information about the role of the SUMO protein, but our theory was that it was critical for proper development of the heart," said Huber. "To study the protein's specific impact, we inhibited SUMO activity in the developing cardiovascular tissue. This will allow us to compare the proteome or all of the proteins that are expressed by a cell of the defective hearts with their normal counterparts."

To support the research, Olivia Cox, a Notre Dame graduate student, collaborated with Daniel Weeks, professor of biochemistry and pediatrics at the University of Iowa, and identified three predominate heart defects in the SUMO-deficient hearts: septal defects commonly thought of as holes in the heart abnormal turning of the outflow tract, and noncompaction cardiomyopathy.

The goal of this research is to use the proteome comparisons to specifically identify which proteins are responsible for congenital heart defects. Additionally, Huber, affiliated with the Harper Cancer Research Institute (HCRI) and the Center for Stem Cells and Regenerative Medicine, and Dovichi, affiliated with Advanced Diagnostics and Therapeutics as well as the HCRI, plan to continue exploring the SUMO protein's significance in other areas of embryo development. This research could help explain why other development defects arise, and eventually lead to a solution for increasing SUMO protein expression when a mutation occurs.

Explore further: SUMO-snipping protein plays crucial role in T and B cell development

More information: Liangliang Sun et al. Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development, Scientific Reports (2014). DOI: 10.1038/srep04365

Small ubiquitin-like modifier (SUMO) proteins are small peptides that get added on to other proteins to regulate their activity. While SUMO has many regulatory roles in cells, it is especially important for controlling gene ...

Of the more than 700,000 Americans who suffer a heart attack each year, about a quarter go on to develop heart failure. Scientists don't fully understand how one condition leads to the other, but researchers in the Perelman ...

An anticancer agent in development promotes regeneration of damaged heart muscle 0- an unexpected research finding that may help prevent congestive heart failure in the future.

A higher volume of a certain type of fat that surrounds the heart is significantly associated with a higher risk of heart disease in women after menopause and women with lower levels of estrogen at midlife, according to new ...

Generating mature and viable heart muscle cells from human or other animal stem cells has proven difficult for biologists. Now, Johns Hopkins researchers report success in creating them in the laboratory by implanting stem ...

Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer. The cells organized themselves in the scaffold to create engineered heart tissue that beats ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Originally posted here:
Sumo protein explored as likely source for some congenital heart defects - Medical Xpress

Pregnant ‘Grey’s Anatomy’ Star Has Big, Feminist Dreams For Her … – Huffington Post

In an empowering Instagram post, Greys Anatomy star Camilla Luddington announced shes expecting a girl, whom she will raise to be a little warrior.

On Feb 3, Luddington posted a photo on Instagram that showed her holding a onesie with the words Tomb Raider in training on it. In her caption, she wrote she was so excited to share the news that she and her partner, Matthew Alan, will be welcoming a baby girl into their family. And Luddington already has big plans for her little one.

I want her to grow up knowing how strong women are, she wrote.

The actress wrote that she will teach her daughter to be kind and to be vocal about what she thinks is right.

[I want her to grow up] to be a little warrior who is not afraid to use her voice and stand up for what she believes is right, she wrote. To navigate through life with courage and kindness, and to be one of the girls who says, You CAN sit with us....

Luddington also posted a funny video of Greys Anatomy co-star Ellen Pompeo directing her in a maternity photo shoot inspired by the pics Beyonc released two days earlier when she announced she was expecting twins.

I mean this is amazing, Pompeo said. You are pregnant at the same time as Beyonc. When is that ever going to happen again, Camilla?

Heres to hoping Luddingtons little warrior will team up with Beyoncs newest members of the BeyHive for some playdates.

The HuffPost Parents newsletter offers a daily dose of personal stories, helpful advice and comedic takes on what its like to raise kids today.Sign up here.

Go here to see the original:
Pregnant 'Grey's Anatomy' Star Has Big, Feminist Dreams For Her ... - Huffington Post

Anatomy of an Ad: Moment of Truth for Tide’s Stain – AdAge.com

"We hope the internet goes crazy."

That's what Amy Krehbiel, P&G associate brand director for Tide, told Ad Age the brand hoped to accomplish from its unprecedented Super Bowl ad in which Terry Bradshaw feigns a stain.

And now, inside the Procter & Gamble war room, during the Big Game, comes Tide's moment of truth. The millions spent, months of hard work and top-level secrecy are all coming to fruition in this 75 seconds.

Will America fall for the stain?

Here is the original post:
Anatomy of an Ad: Moment of Truth for Tide's Stain - AdAge.com

Anatomy of Ahmedabad’s road accidents – Times of India

AHMEDABAD: The city reports six deaths per week on the road. Victims vary from senior citizens crossing a road to youths high on liquor behind wheels. Out of over 3,000 road accidents reported with EMRI 108 ambulances, majority take place in the city periphery on roads such as SG Road and SP Ring Road. Why do these accidents take place, and how to reduce fatalities?

A report by JP Research India, titled 'Ahmedabad and Gandhinagar Road Accident Study' analyzes 211 accidents that took place between February 2004 and February 2015 on the 31-km stretch of SG Road, 27 km of SP Ring Road, 13.5 km of NH8 and 27 km of state highways passing near or through Ahmedabad and Gandhinagar.

The study is part of a national scientific database called "Road Accident Sampling System - India" (RASSI). It is submitted to the state transport commissioner by the agency. According to the research, cars and two-wheelers posed highest risk of accidents among road users. Both segments were found involved in 56% (28% each) of total road accidents. Moreover, two-wheelers were most affected - having been involved in 53% of fatal accidents and 47% of serious accidents. The study mentions that only 22% of the total road accidents get reported to police. Moreover, out of 211 accidents, 34% were serious accidents, 8% fatal and 48% minor. In 8% cases, there were no injuries whereas in 2% cases there is unknown outcome.

See original here:
Anatomy of Ahmedabad's road accidents - Times of India

Professional Idiot: an Anatomy – PoliticalCritique.org

The inauguration of President Donald Trump revealed that the USA has more in common with the Czech Republic than anyone (presumably, Americans least of all) had hoped for.

President Trumps inauguration ceremony was a flop, at least within the parameters of the universe most of us live in. A universe, it turns out, not shared by Trump and his Press Secretary Sean Spicer. America is getting its first glimpse into the wonderful world of alternative facts, coming from the highest level and it honestly seems a bit shocked. But worry not dear, poor America: you are not the first nor the last. We have been there. We can share survival tips.

The Antichrists Lesson

For starters, there are historical precedents. When the then-President of the Czech Republic Vclav Klaus decided to employ known conspiracy theorist Petr Hjek, most famous for denying evolution, claiming that 9/11 was an inside job, and accusing the late Havel of having been a servant of Satan, he left more than a few heads scratching. Hjek, however, possessed a very useful ability: should it ever become necessary to draw the medias attention, he could always give an interview and bleat something about the Antichrist among us. And then shock and awe would follow.

It was not that what he claimed was particularly interesting or original; the trick was doing it from a position of authority.

This man worked directly for the president and because of that, when he spouted his drivel, the media listened because they simply could not afford to ignore him, especially with the appeal of pure, unadulterated bullshit being so high to audiences. Remove the authority, however, and you get just another conspiracy nut job with a blog. Which, coincidentally, is exactly what became of Hjek.

Now, it seems President Trump possesses a pet lunatic of his own in the person of his Director of Social Media, Dan Scavino. Hoaxes, conspiracy theories, smear campaigns, he has shared it all. The biggest challenge he has faced was to defend his lord and master after Trump retweeted an image from a white supremacist message board. Trumps campaign placed heavy emphasis on social media and there was no indication this would stop once he came in power so it will be quite a surprise if we do not hear more of the talented Mr. Scavino in the near future, and quite possibly in a newfound capacity as a sacrificial lamb. The thing about crackpots is that there are always more where they came from.

There is a lesson and a warning in this comparison: people in power always like having an idiot around and being near that power entitles said idiot to inflict his views on the country. So, dear America, you should prepare for a new onslaught of flashy nonsense.

Going Professional

The most obvious analogy, however, is that between the current presidents of the Czech Republic and the United States. Both President Zeman and President Trump are populists who declare strong pro-Russian views, both love the use of fear mongering and xenophobia to garner popularity and both possess a relationship with facts that can be described as tenuous at best. They also both employ PR specialists whose job descriptions include publicly ignoring realty.

In spite of rather overwhelming photographic evidence to the contrary, Sean Spicer claims President Trumps inauguration gathered the biggest crowd ever. It is a public, shameless lie delivered from a position of authority. It is, also, something that the Czech Republic happens to have experience with, especially given the results of last Novembers presidential vote gathering tour (above: the official version; below: police camera at the other end of the square). And it is an extremely efficient means of dealing with the pesky media.

Lenin is said to have coined the term useful idiot and a tame conspiracy theorist works very well in that role. Presidents Trump and Zeman, however, took this a step further.

What we have in Spicer and Ovek is a logical evolution: the professional idiot.

Here is how it works: the president either slips up or unabashedly tells a lie about, say, a historical article that totally exists or the oh-so-huge Chinese investments in the Czech Republic. The Media points it out and in steps Ovek, either insisting on the lie, producing an alternative and even more outrageous statement or attacking the media in extremely petty ways. Standard PR practice where the truth does not enter the process at any point, right? But there is a difference: professional idiocy results in the unprecedented presence of Zeman in the media the Czech Republic is not a presidential system, the man is there literally just to ruin our reputation abroad. Yet his every (mis)step is religiously followed by the media and he uses it to the maximum to voice populist views quite likely to help him in the next election after all, terror is coming!

Jester to Speaker

The professional idiot strategy works simultaneously as an attention grab and misdirection. Consider President Trumps inauguration mess. Almost immediately afterward, Trump followed it up with a lie about the popular election presumably the same invisible crowd present at his inauguration that happened to have voted invisibly by casting invisible ballots into invisible boxes. Americas stealth plane technology has apparently entered the public domain.

Meanwhile, Spicer proves that he is a real pro in the idiot biz by attacking the media and pitching another shovelful of bullshit towards the pile by stating that the inauguration had the largest audience ever, and by the way, why are we still talking about this and can we get to running that pipeline over Sioux sacred grounds again already?

A professional idiot possesses no qualms about ethics or taste and will most certainly not let something as trivial as facts slow him down on his way towards attention. An analogy to the time-honored institution of the court jester comes to mind, although with a rather crucial difference: while in ages past it was the jesters prerogative to talk smack in the presence of the monarch and to the monarch, it seems a supremely stupid suggestion to have the jester speak for the monarch.

To Wage War on Reality

There is another, altogether more sinister turn to this. A professional idiots job (which, at least in some cases, appears to be a hobby as well) is a symptom of society. Post-truth is the buzzword that immediately comes to mind, but there is more. A systematic denial of reality is also a tool of totalitarian propaganda: recall that the crowning achievement of indoctrination is doublethink. This is something professional idiots seem to radiate effortlessly, especially when flocking around politicians with dictatorial tendencies.

It is entirely possible that Spicer cheered along with the invisible crowd at the inauguration, that Zeman and Ovek read the article on the bottom left of the page and that Trump has evidence that the popular vote was tampered with by millions of illegal voters. We all do this to some extent mentally editing experiences and memories to fit our own world-view. It only becomes problematic once the person in question is unaware of the factand in possession of power.

And so we get alternative facts instead of lies, different recollections instead of mistakes and quickly evolving opinions instead of contradictions. It is a sign of the times. Perfectly natural. Nothing wrong about this sign of the times, we got the best times in the world.

Do not worry, America. You will be alternatively fine.

Go here to read the rest:
Professional Idiot: an Anatomy - PoliticalCritique.org

Studies reveal link between rotator cuff disease and genetics – News-Medical.net

A new study presented this week at the Association of Academic Physiatrists Annual Meeting in Las Vegas shows rotator cuff disease might be a heritable trait.

Rotator cuff disease is a common disorder that affects 30 to 50 percent of people over the age of 50. The disease often leads to shoulder pain and loss of function. While many think of this as a 'tear' due to an injury or sustained over/misuse, some studies suggest genetics might play a role.

"People are living longer and more active lives, but a large percentage of these people may suffer from rotator cuff disease," explains Lead Investigator in the study, Dominique Dabija, MS, a medical student at Vanderbilt University School of Medicine. "Identifying a genetic link can help early recognition of individuals at higher risk and could warrant application of prevention strategies for this specific population.

To assess if there could be a genetic or familial predisposition to rotator cuff disease, Dabija along with Chan Gao, MD, PhD; Todd L. Edwards, MS, PhD; John Kuhn, MD, MS; and Nitin B. Jain, MD, MSPH, also from Vanderbilt University Medical Center looked through two databases (PubMed and EMBASE) that hold thousands of medical research studies to identify those using the term "rotator cuff." They searched all studies in the databases through March 2016 and narrowed down 251 citations to seven studies that were relevant to their literature review.

"Different studies on similar topics may produce different results depending on the specific methods and populations looked at," explains Dabija. "Our literature review compiles all of these studies to look at the data on a larger scale, and this allows us to identify macro trends as well as research gaps that need to be filled."

Four of the seven studies reviewed by Dabija's team assess whether there is a familial predisposition to rotator cuff disease. One of these found if an individual has a sibling with a rotator cuff tear, he or she is twice as likely to also have a tear and nearly five times more likely to have associated pain and loss of function. This is in comparison to if that individual did not have a sibling with a tear.

Another study reviewed by Dabija's team showed that a significantly higher number of individuals with tears (32.3 percent) had family members with a history of tears or surgery on their rotator cuffs than those without tears (18.3 percent).

A third study found if an individual is diagnosed with a rotator cuff tear before the age of 40, there is a higher likelihood that any of his or her family members immediate or extended will also have a tear. In contrast, if an individual is diagnosed with a rotator cuff tear after the age of 40, only close family members parents, siblings, grandparents, aunts/uncles have a higher likelihood of having a tear. This difference may also be attributed to environmental factors.

The other three studies investigated whether there is a genetic predisposition to rotator cuff disease, and these noted certain patterns of genes were found more often in people with rotator cuff disease when compared to those without rotator cuff disease.

"Although there was a small number of studies in this literature review pointing to a need for more studies on this topic the consensus among all seven studies is rotator cuff disease is a heritable trait," says Dabija. "More large-scale studies need to be performed, and these results can assist in identifying individuals at higher risk of developing a tear and then help them before they have pain."

Go here to see the original:
Studies reveal link between rotator cuff disease and genetics - News-Medical.net

Seattle Genetics, Inc. (NASDAQ:SGEN) earnings reaction history – The Independent Republic

Seattle Genetics, Inc. (NASDAQ:SGEN) is projected to declare fiscal fourth quarter financial results right after the stock markets official close on February 09, 2017. The stock added about 22.4 percent in price since last results when it was at $49.93 a share. Based on the most relevant past-periods data, there is an 60.71 percent probability for this firms share price to go down following next quarterly results. Earnings reaction history tells us that the equity price moved down 17 times out of last 28 reported quarters. It has beaten earnings-per-share estimates 66% of the time in its last 12 earnings reports. It fell short of earnings estimates on 4 occasions, and it has met expectations 0 time.

Heres how traders responded to SGEN earnings announcements over the past few quarters.

Seattle Genetics, Inc. (SGEN) Earnings Surprises & Reaction

Given its history, the average earnings announcement surprise was 2.19 percent over the past four quarters. Back on October 27, 2016, it posted earnings per-share earnings at $-0.23 which beat the consensus $-0.29 projection (positive surprise of20.69%. For the quarter, revenue came in at 106.32M versus consensus estimate of 101.74M. The stock gained 1.84 percent the session following the earnings reports were released, and on 7th day price change was 14.16 percent.

On July 26, 2016, it reported earnings at $-0.23 a share compared with the consensus estimate of $-0.33 per share (positive surprise of 30.3%). Revenue of 95.4M for that quarter was above the $94.13M analysts had expected. The stock climbed 9.62% the day following the earnings announcement, and on 7th day price change was 10.85%.

On April 28, 2016, it recorded $-0.15 a share in earnings which missed the consensus estimate of $-0.11 (negative surprise of -36.36%). Revenue for the quarter was $111.15M while analysts called for revenues to be $116.04M. The stock dropped -4.85% the day following the earnings data was made public, and on 7th day price change was -10.91%.

On February 9, 2016, it announced earnings per share at $-0.18 versus the consensus estimate of $-0.17 per share (negative surprise of -5.88%). That came on revenues of $93.48M for that period. Analysts had expected $88.28M in revenue.

Seattle Genetics, Inc. Earnings Estimates

As Q4 earnings announcement date approaches, Wall Street is expecting earnings per share of $-0.31. The analysts present consensus range is $-0.42-$-0.25 for EPS. The market consensus range for revenue is between $91.86M and $117.07M, with an average of $106.17M.

Seattle Genetics, Inc. (NASDAQ:SGEN) last ended at $61.11, sending the companys market cap near $8.65B. The consensus 12-month price target from analysts covering the stock is $58.79. The share price has declined -18.91% from its top level in 52 weeks and dropped 15.8% this year. It recently traded in a range of $59.57-$61.16 at a volume of 444485 shares. The recent trading ended with the price nearly 4.48 higher for the last 5 trading days, rebounding 134.86% from its 52-week low.

See the original post:
Seattle Genetics, Inc. (NASDAQ:SGEN) earnings reaction history - The Independent Republic

The embryologist entrepreneur – BQ Live

Tell us about your businesses, Caroline.

I run two businesses. Alba SEO services provides digital marketing services to Scottish based SMEs whilst Fertility Clinics Abroad is an online portal which provides impartial information and advice to people seeking fertility treatment outside of the UK.

And how did you get from working as an embryologist to running your own business?

After completing my PhD from Edinburgh University in Mammalian Embryology followed by a two year research project, I began working as an embryologist at the London Fertility Centre Harley Street and then as a senior clinical embryologist at the IVF Unit at the Chelsea and Westminster Hospital. In 1996, I decided to move back home to Edinburgh and took up another two year research post.

The research was successful, but the project was moving to Western Australia with my research leader and I wasnt keen to move, so I began thinking about a change of career. I was looking for a more stable job with set hours lab work is great but the hours can be inconsistent.

I went back to university again and attained an MSc Diploma in Information Technology from Napier University which was a springboard to a graduate entry with the IT services department at the Royal Bank of Scotland. I had always had an interest in IT, so this was my chance to gain some experience in a new field. I got the job and ended up working at the Bank for 12 years.

I was part of a team that processed the money that went through the ATM machines, before moving to the service improvement department. Working part-time suited me as I had a young family and it fitted in with my work-life balance.

In 2011 I was made redundant and so an opportunity was opened up for me. I had been thinking about starting a business that utilised my skills in IT and my knowledge and experience in embryology and Fertility Clinics Abroad seemed like the perfect fit.

My work as a senior embryologist made me realise how little information was available to people looking into fertility options outside of the UK there was a real gap in the market for a one stop shop service where you could access all the required information from one place. When the opportunity arose to set something like this up, I felt compelled to go for it.

Once Fertility Clinics Abroad was up and running, the idea to set up a separate digital marketing company came pretty quickly. FCA is a web based platform, so I knew that I needed to improve my website ranking to attract more people to the site. I started reading and buying books about Search Engine Optimisation. I spent about a year on my own site and achieved a page one Google ranking - I thought to myself, if I can do that on my site, why can't I apply what I know to others?

So that's exactly what I did. I created another business called Alba SEO Services, built a website and proceeded to get it to the top of Google too. By doing that, I got noticed and businesses started to come to me for help. At that point Alba was officially born! Now I run FCA and Alba in conjunction with each other. In fact, FCA could be considered a client of Alba.

Was there a desire to run your own business generally?

The desire has definitely always been there. I have always craved the flexibility and freedom that comes with running your own business. There is something refreshing about managing a small business I am used to the bureaucracy of large corporations that that can be slow and cumbersome in comparison to SMEs. When you have your own business, you can introduce and test news ideas, bring in new revenue streams, experiment without any proverbial hoops to jump through. You are the master of your own destiny, if you will.

How did you learn all of the skills you need to be successful marketing, bookkeeping etc?

Most of the SEO skills I needed to set up Alba were self-taught and came about from running Fertility Clinics Abroad. I read books, did a lot of online research and learnt by testing things on my own site.

You could say my first company was the training ground for the second business I set up. Of course I also learnt a lot while working at RBS bookkeeping, processing records, team building, people management where all part of my role at the bank and put me in good steads for setting up my own company.

However I think any business owner would admit that no-one goes into business knowing everything there is an element of learning on the job. Its ok to make mistakes as long as you adapt and learn from them.

Why is there a need for your business?

Everything is online these days and most people use Google to find a business, or to buy a product or service. If your business is hidden on page two of Google, you won't get found.

So all businesses need to step up their marketing and make their websites as search friendly as possible. We are seeing demand from companies of all sizes soar everyone wants a website and everyone wants their website to be sitting at the top of Google searches.

Of course, increasing competition makes achieving this goal harder to come by, which is why companies that provide specialist SEO and digital marketing services are in big demand.

What does the future hold for your businesses?

We are hoping to grow Alba over the next few years. This time last year there were two of us, now there are four, so we are moving in the right direction. In the future, Id like to be more hands off so I can manage the business rather than implementing campaigns and getting involved with the day to day work. Id say working on the business rather than working in the business.

Im potentially looking to take someone on to take on more of the account management role to allow me to step back a little.

Regarding FCA were looking to become the number one place to go for impartial, high quality information about fertility treatment abroad key to this is having a critical mass of clinics listed so that I can give a truly representative view of the industry across Europe.

However, Im not really looking to grow in the sense of employing people or generating new revenue streams. Its more about improving the quality and quantity of information we provide

Read more:
The embryologist entrepreneur - BQ Live