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Following industry trend, Merck offloads mid-stage immunology candidate – The Pharma Letter (registration)

Merck KGaA and London-based Avillion have signed an agreement to collaborate on the development of the

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Following industry trend, Merck offloads mid-stage immunology candidate - The Pharma Letter (registration)

2 alumni to present at Lubbock Christian U’s Scholars Colloquium – LubbockOnline.com

Two Lubbock Christian University alumni, as well as several undergraduate students and faculty, are presenting at the LCU Scholars Colloquium on Thursday and Friday.

The Scholars Colloquium serves as a forum for undergraduate research and scholarly presentations by LCU students.

Matt Joyner, another LCU alumnus and assistant professor of biochemistry at Pepperdine University, teaches biochemistry and investigates the chemical and pharmacological properties of native medicinal plants used by local American Indians. His presentation will be offered in the Baker Conference Center at 10:45 a.m. on Friday.

The colloquium has become a grand tradition of honoring our students and faculty for their research, and a way to show the larger community that the academic quest at LCU is strong and vibrant, said Stacy Patty, director of LCUs Honors Program and a professor of religion.

Crystal Silva-McCormick, a graduate of LCU and a doctoral candidate in Interfaith Relations at the Lutheran School of Theology in Chicago, will be addressing issues of injustice, particularly among those poor and marginalized in society, and how poverty is interrelated to both injustice and economic disadvantages. Her presentation is scheduled for Thursday at 7 p.m., and it will be given in the Collier Auditorium in the Talkington Center for Nursing Education.

In addition to the keynote addresses, there will be more than 90 presentations and posters during the Scholars Colloquium, a combination of seniors doing capstone projects and other students presenting findings from their scholarly research at the undergraduate level. LCU faculty will also make research presentations.

All presentations are free and open to the public. Please see lcu.edu/scholars for the full Scholars Colloquium schedule.

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2 alumni to present at Lubbock Christian U's Scholars Colloquium - LubbockOnline.com

Online Medical Biochemistry: Online Biochemistry Course

Contact Us: (855) 325-0894 | Email our Staff

UNE Academic Calendars| UNE Academic Catalog|Technical Requirements

This is a one-semester online Biochemistry course designed for individuals who need first semester Biochemistry as a prerequisite to apply for admission to a program in the health professions.

Graduate programs that may require a CHEM 1005 Medical Biochemistry class include:

Medical Biochemistry is a four credit hour course designed to lay the foundation for other basic and clinical medical sciences. The goal of this course is to learn the core concepts of biochemistry that apply to human health and disease and to cite specific examples of their application. You will be able to analyze and evaluate the most common biochemistry cited in medical literature. Furthermore, these basics will facilitate further learning in biochemistry and the health sciences.Click here for the online Biochemistry course syllabus.More detailed readings are available on Blackboard.

The typical student will complete this online Biochemistry course in approximately 16 weeks. Many students are nontraditional students who have elected an online course for flexibility. Since the course is self-paced, you may complete the course in fewerthan 16 weeks.

One semester of college level biology, and one year of chemistry that includes one semester of organic chemistry.All prerequisite courses must have been completed successfully within the past seven years.

To learn more about the technical requirements for this and other Post-Baccalaureate courses, click here.

Credits: 4 Tuition: $1320 Registration: $25 Total: $1345

The cost of the materials is not included in this total.

All exams are taken online. Major exams are required to be proctored. For instructions on how to take your exams online, visit Online Learning's ProctorU site.

You may enroll at any time via our self-service registration portal.Please keep in mind that courses start on the 1st and 3rd Wednesdays of the month. Payment is due in full atthe time of registration. Your official start date is the date that the course opens, and you will have 16 weeks from that date to complete your course.

You must be registered for yourclass by 12:00 noon EST on the Mondaybefore the class starts.See the UNEAcademic Calendarfor more details.

If you have any questions or need help with registering for your class, please callan Enrollment Counselorat1-855-325-0894, email prehealth@une.edu, or view the online FlexReg course registration tutorial.

If you intend to useVA Benefits or Military Tuition Assistance, please do not usethe self-registration portal. Please call 1-855-325-0894 to be directed to the appropriate office for assistance.

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Online Medical Biochemistry: Online Biochemistry Course

Anatomy of a SpaceX launch – USA TODAY

By Frank Pompa, Ramon Padilla, Mitchell Thorson USA TODAY

March 30, 2017

SpaceX will attempt to make history Thursday night by reusing a rocket booster. The Falcon 9 rocket will deliver a communications satellite into orbit using a first-stage system that they used nearly a year ago. Heres a look at SpaceXs feat to launch and land the system back on Earth.

The Falcon 9 is a two-stage rocket used to transport satellites and the Dragon spacecraft into orbit.

Aluminum-lithium alloy tanks fuel nine Merlin engines with liquid oxygen and rocket-grade kerosene propellant, generating more than 1.7 million pounds of thrust.

The main engines are cutoff as Falcon 9 nears the edge of Earths atmosphere.The total burn time from launch is 162 seconds.

Once beyond Earths atmopshere, the pneumatic stage separation system releases the first stage from the second stage. A single Merlin engine fires, propelling stage two into orbit.

The fairing separates from the second stage,exposing the satellite. Merlin engines ignite on the first stage, setting it on a trajectory for the landing site.

The second stage releases the satellite into a predetermined orbit.

The first stage undergoes a flip maneuver using onboard cold gas thrusters. When complete, it is positioned with engines forward.

The first stage grid fins deploy and engines do a temporary burn to slow it down. The grid fins will steer stage one as it enters Earths atmosphere.

Landing legs deploy and engines light a final time to land the first stage safely on a designated landing platform.

Source: SpaceX

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Anatomy of a SpaceX launch - USA TODAY

An Exoneree Shares His Story Of Wrongful Conviction In ‘Anatomy … – NPR

Jerry Miller says he always held out hope for exoneration. "I made a logical decision to do positive things and to think positive," he says. Courtesy of the Innocence Project hide caption

Jerry Miller says he always held out hope for exoneration. "I made a logical decision to do positive things and to think positive," he says.

Jerry Miller spent more than 25 years behind bars for kidnapping, rape and robbery crimes he didn't commit.

Miller was released from prison in 2006. In 2007, after decades of insisting he was innocent, Miller was finally vindicated: He became the 200th American to be cleared by DNA evidence of a wrongful conviction. Today, that number is closer to 350.

Miller's story is now part of a new book called Anatomy of Innocence. It fleshes out personal accounts of wrongful convictions, with a twist: In each chapter, a mystery or thriller writer tells the story of a real-life exoneree.

Miller was paired with John Mankiewicz, an executive producer of the Netflix show House of Cards. Their chapter goes beyond the years Miller spent behind bars, and describes life after prison but before exoneration, when Miller had to wear an ankle bracelet, keep a 9 p.m. curfew and register as a sex offender. He couldn't attend nieces and nephews' birthday parties because he wasn't allowed to be around children.

Miller shares his memories of the day he was exonerated, and Mankiewicz discusses the challenges of telling Miller's story.

On how Miller managed to stay hopeful after his conviction

Miller: I had a life to live, so I had to choose how I wanted to live it, you know. What comes from a man who is negative and basically is mad at the world because he was wronged? You can't, I can't function I couldn't function like that. And I couldn't draw people to my aid like that. You just have to accept what has happened and grow from it. You know, to just walk around angry, you know, in some cases an angry old man I mean, that's a waste of the rest of your life. I'm more practical than that. I made a logical decision to do positive things and to think positive.

On the day Miller was exonerated

Miller: Even now I kind of get a little shook. ... I was getting ready to get my life back. I knew it was going to happen. It was strange and, you know, my family, we basically had a caravan. We rode out to the [Cook County, Ill.,] court building down at 26th and California. And everybody was dressed sharp and, you know, was happy for me. And I just was real proud that I didn't give up. ...

John Mankiewicz's other TV credits include The Mentalist and House. Courtesy of Laura Caldwell and Liveright Publishing hide caption

John Mankiewicz's other TV credits include The Mentalist and House.

When they called me up before the judge, I passed through people who was waiting to have their cases heard or whatever, and they saw the news media and they was like, "Who is that? Who is that? What's going on?" ... I'm hearing them, but I'm focused. I have to go up here and maintain my cool in front of this judge. And so when it all happened and they saw what was taking place, everybody it was a lot of people, you know, waiting and everybody started clapping.

On how writing Miller's story was different from writing House of Cards

Mankiewicz: I felt a big responsibility to tell the story right. ... I had a very small audience of one [Miller] that I cared about ... thinking that I'd gotten it right. ... So many other people had been telling lies about him over a period of 26 years, you know, what happened to him. And I wanted to get it right for him.

And, by the way, you're writing House of Cards; the worst thing that can happen is it's a bad show. It's TV. I felt the stakes were a little higher here. ...

If you think about every exoneree, every single one who's actually innocent, no one has believed them and no one has been interested in hearing what the real story was until they're exonerated. You know, they're just another man or woman in jail saying, "I'm innocent. I didn't do it. How am I going to prove it?" ... While we were doing this, writing the story, which I over reported by a factor of 10 because I was so nervous ... I wanted to get it right.

On what Miller hopes the book will accomplish

Miller: I've heard stories even worse than mine, but the interesting stories in there are about reality. You know, it's not a fantasy, it's nothing made-up; these are real people who suffered real pain, who [have] to find their way back to being a productive citizen. And they need support.

For people not to hear this story, I mean, they would be missing out on the triumphs of human beings and how they're able to struggle hard enough to regain their life back and, you know, clear their family's name. They're important stories that need to be told. ... People don't know ... what it takes to accomplish what exonerees do. They're like the phoenix: They're redone, resurrected.

Editor Jessica Deahl, producer Sam Gringlas and digital producer Nicole Cohen contributed to this report.

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An Exoneree Shares His Story Of Wrongful Conviction In 'Anatomy ... - NPR

Grey’s Anatomy stars tease emotional Ellen Pompeo-directed hour – EW.com (blog)

Ellen Pompeo will make her directorial debut during what might be the most emotional hour of Greys Anatomy this season. The heavy episode zeroes in on Maggies (Kelly McCreary) plight in the wake of learning that her mother Diane (LaTanya Richardson Jackson) has cancer and her health is quickly deteriorating.

Shes dealing with mountains of emotion, McCreary tells EW. Not only is she dealing with the news that her mom has cancer, but that the initial attempt to tackle it was not successful. Its even more complicated than the already really frightening diagnoses of IBC. Shes dealing with that, shes dealing with having the truth withheld from her from both Jackson [Jesse Williams] and her mother, and shes dealing with a sense of deep regret that she behaved in the way she did because of the misunderstanding between her and her mother.

But Maggie wont let her mother go down without a fight, pushing beyond both Dianes limits and the hospitals in a bid to save her mom. Maggie is such an optimist, and shes such a hard worker, McCreary notes. She feels really empowered by that, so after the initial shock, shes going to get to work and do her best to help. Shes determined to be solution-oriented, and find a way to make her mother well no matter what. Shes a brilliant doctor, she has all the resources, and she believes that this is a problem she can solve.

RELATED: Greys Anatomy cast offers hope for couples of Grey Sloan

The episode proved to be pretty intense material for Pompeos first time directing. The [potential] death of a mother is so quintessentially Greys Anatomy, Pompeo says. I was really excited to get that episode. Meg Marinis wrote it, and I couldnt have had a better partner with me and Meg together we get along so well, Im such a fan of her work. Its a beautiful episode, wonderfully acted by Kelly McCreary and LaTanya Richardson Jackson. Were just dealing with this one story, but I think its beautiful.

Pompeo and McCrearysought to make Maggies experience as relatable as possible. I had a moment one day of being on set and realizing that everyone in the room with me has probably dealt with the fear of losing someone, McCreary says. What that gave me, and that Ellen really teased out with her direction, was remembering how universal this experience is and how everyone goes through it in a different way. What I felt most strongly about was stripping away to the absolute truth of Maggies circumstances, the particulars of her mothers illness, that our audience could relate to in watching the story.

Greys Anatomy airs Thursdays at 8 p.m. ET on ABC.

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Grey's Anatomy stars tease emotional Ellen Pompeo-directed hour - EW.com (blog)

Another neuroscience breakthrough from Brown, VA BrainGate partnership – The Providence Journal

Man paralyzed in accident from shoulders down can now feed himself, drink water -- even scratch his nose

PROVIDENCE, R.I. In another dramatic breakthrough for BrainGate, the neuroscience consortium that includes Brown University and the Providence VA Medical Center, new technology has allowed a man paralyzed from the shoulders down to move his arm and hand again. He can now feed himself, drink water from a mug -- and even scratch his nose.

For somebody whos been injured eight years and couldnt move, being able to move just that little bit is awesome to me, said the man, Bill Kochevar, 56, who suffered a severe spinal cord injury in a bicycling accident. Its better than I thought it would be.

Kochevar achieved these abilities with the use of BrainGates investigational brain-computer interface in combination with a the consortiums so-called functional electronic stimulation system, which was implanted in the Cleveland mans arm.

The advance is deemed so significant that it is featured this week on the online edition of The Lancet, one of the worlds leading medical journals, published since 1823.

Its so inspiring to watch Mr. Kochevar move his own arm and hand just by thinking about it, said Dr. Leigh Hochberg, a study co-author and director of the BrainGate2 pilot clinical trial. As an extraordinary participant in this research, hes teaching us how to design a new generation of neurotechnologies that we all hope will one day restore mobility and independence for people with paralysis.

The technology works by detecting neural signals acquired from electrodes implanted in the surface of the motor cortex of the brain," according to Brown.Those signals are translated by the collaborations algorithms into movement commands for assistive devices. In the new research, the movement commands were relayed to a functional electronic stimulation system that electrically stimulated Kochevars muscles, allowing him to bypass his injury and once again deliver his brains motion plan to his arm.

The BrainGate consortium also includes Case Western Reserve University, which led the latest research, Stanford University and Massachusetts General Hospital.

In February, the team announced another ground-breaking development: technology that allowed three people with paralysis to type using only brain control.

As with the development reported in February in the journal eLife, Hochberg said more work remains before the technology that benefitted Kochevar could be available to more people.

While todays exciting report was made possible by incredible team science and vital federal funding for fundamental, translational and clinical research, these are still just the first steps, he said. Watching him move his hand again reminds me of the enormous potential for research to provide the new insights and technologies that will reduce the burden of neurologic disease and restore function.

WATCH a video of Kochevar using his arm and hand and talking about the accident that left him a quadriplegic.

gwmiller@providencejournal.com

(401) 277-7380

@GWayneMiller

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Another neuroscience breakthrough from Brown, VA BrainGate partnership - The Providence Journal

Two Postdoctoral Fellows Researching Immunology and Cancer … – SelectScience

ACEA Biosciences, a privately owned biotechnology company that develops cutting edge instrumentation for cell-based assays, disperses a quarterly travel award to noteworthy scientists who will be presenting research using ACEA Biosciences technology at scientific conferences. Today the company announced that its new round of awards are being given to two postdoctoral fellows studying pathogen capture by neutrophils, and the impact of epigenetics on chemotherapy efficacy.

Dr. Calum Robb (pictured left), a postdoctoral fellow in the laboratory of Dr. Adriano Rossi at the University of Edinburgh Medical School, was selected for his poster entitled Flow cytometric assessment, quantification and regulation of human neutrophil extracellular traps which he will present at the CYTO 2017 Conference being held June 10-14 in Boston, MA. Beyond their well characterized role as phagocytes, granulocytic neutrophils are also able to ensnare and neutralize pathogens using a secreted extracellular fibril matrix consisting of DNA, histones, and a variety of anti-bacterial proteins. Though the employment of these neutrophil extracellular traps (NETs) is thought to be an evolutionarily ancient defense strategy, the mechanisms regulating this process are not yet fully understood. With the goal of elucidating these mechanisms, Robb developed a NovoCyte flow cytometer-based assay that enabled him to track changes in NET formation when key proteins or pathways were pharmacologically modulated. Using this approach, Robb probed the roles of superoxide anion, intracellular calcium pools, and the phospholipase C pathway in NET formation. The efficiency and versatility of Robbs assay are expected to accelerate the rate of progress in this relatively new field.

Dr. Rentian Wu(pictured right), a postdoc in the lab of Dr. Robert Diasio at the Mayo Clinic, was selected for his poster entitled Trimethylation and acetylation of histone H3K27 modulates 5-fluorouracil response by regulating DPYD expression which he will present at the 2017 American Association for Cancer Research meeting taking place April 1-5 in Washington D.C. Though it is one of the most widely used chemotherapy drugs, the antimetabolite 5-fluorouracil (5-FU) displays substantial variability in its efficacy and toxicity among patients. This variability is due, at least in part, to differences in the activity of DPD, the enzyme which initiates the catabolic degradation of 5-FU to inactive metabolites. Though mutations in the DPD gene can affect 5-FU metabolism, these variants are rare and cannot by themselves explain the variation in DPD activity that is observed among patients. In search for the cause of variable DPD activity, Wu used the xCELLigence Real-Time Cell Analyzer in combination with both chemical inhibitors and genetic approaches to demonstrate that the DPD gene is epigenetically regulated by histone modification at promoter and enhancer regions. This new layer of information has the potential to help clinicians predict more accurately how a patient will respond to 5-FU treatment.

To learn more about ACEAs Travel Award, see profiles of past winners, or download the application form for future funding cycles, click here.

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Two Postdoctoral Fellows Researching Immunology and Cancer ... - SelectScience

People who think about this stuff don’t think bad online behavior will get better any time soon – Nieman Journalism Lab at Harvard

The quality of public discourse online is not going to get better and may actually get worse over the next decade, according to a survey released Wednesday by the Pew Research Center that invited 8,000 technology experts, scholars, corporate practitioners and government leaders to respond.

Forty-two percent of the 1,537 participants said they anticipate no major change in levels of online trolling and other harmful behavior that is found online. Another 39 percent said the next decade will be more shaped by these types of online behaviors.

While respondents expressed a range of opinions from deep concern to disappointment to resignation to optimism, most agreed that people at their best and their worst are empowered by networked communication technologies, the studys authors wrote. Some said the flame wars and strategic manipulation of the zeitgeist might just be getting started if technological and human solutions are not put in place to bolster diverse civil discourse.

Pew and Elon Universitys Imagining the Internet Center conducted the survey between July 1 and August 12, 2016, before the height of the divisive U.S. election.

The report categorizes responses into four primary themes that outline what the future of online discourse might hold:

Many respondents think things will just get worse as humans continue to evolve to a relatively new medium.

I would very much love to believe that discourse will improve over the next decade, but I fear the forces making it worse havent played out at all yet, technology consultant Jerry Michalski said. After all, it took us almost 70 years to mandate seatbelts. And were not uniformly wise about how to conduct dependable online conversations, never mind debates on difficult subjects. In that long arc of history that bends toward justice, particularly given our accelerated times, I do think we figure this out. But not within the decade.

We see a dark current of people who equate free speech with the right to say anything, even hate speech, even speech that does not sync with respected research findings, an anonymous MIT professor said. They find in unmediated technology a place where their opinions can have a multiplier effect, where they become the elites.

The social media ecosystem is attention-driven; the platforms themselves make money from advertising and, as a result, want to continue to drive participation. And because the platforms are so crowded, its often the loudest voices that get the most attention, which carries over into our larger political debates.

Distrust and trolling is happening at the highest levels of political debate, and the lowest, said researcher Kate Crawford. The Overton Window has been widened considerably by the 2016 U.S. presidential campaign, and not in a good way. We have heard presidential candidates speak of banning Muslims from entering the country, asking foreign powers to hack former White House officials, retweeting neo-Nazis. Trolling is a mainstream form of political discourse.

And as social medias influence has grown, traditional media outlets have seen their influence wane. Heres how Steven Waldman, the founder and CEO of LifePosts, explained it:

It certainly sounds noble to say the internet has democratized public opinion. But its now clear: It has given voice to those who had been voiceless because they were oppressed minorities and to those who were voiceless because they are crackpots. It may not necessarily be bad actors i.e., racists, misogynists, etc. who win the day, but I do fear it will be the more strident.

Some respondents were more optimistic that the levels of online discourse would improve over the next decade. Artificial intelligence and other technological improvements will help improve dialogue, some said.

I expect we will develop more social bots and algorithmic filters that would weed out the some of the trolls and hateful speech, Marina Gorbis, executive director of the Institute for the Future, said. I expect we will create bots that would promote beneficial connections and potentially insert context-specific data/facts/stories that would benefit more positive discourse. Of course, any filters and algorithms will create issues around what is being filtered out and what values are embedded in algorithms.

Additionally, as platforms become more influenced by algorithms, respondents expect to see continued fragmentation of the online ecosystem.

There will still be some places where you can find those with whom to argue, but they will be more concentrated into only a few locations than they are now, senior design researcher Lindsay Kenzig said.

Respondents also expressed concern that increased regulation of online spaces could result in surveillance and censorship. They also worried that people would begin to change their positive online behaviors as surveillance increase.

Rebecca MacKinnon, director of the Ranking Digital Rights project at the New America foundation, said shes worried about the state of free speech online:

The demands for governments and companies to censor and monitor internet users are coming from an increasingly diverse set of actors with very legitimate concerns about safety and security, as well as concerns about whether civil discourse is becoming so poisoned as to make rational governance based on actual facts impossible. Im increasingly inclined to think that the solutions, if they ever come about, will be human/social/political/cultural and not technical.

Queensland University of Technology professor Marcus Foth warned that the increased regulation of online speech could result in polarization and filter bubbles:

With less anonymity and less diversity, the two biggest problems of the Web 1.0 era have been solved from a commercial perspective: fewer trolls who can hide behind anonymity. Yet what are we losing in the process? Algorithmic culture creates filter bubbles, which risk an opinion polarization inside echo chambers.

The full report, in which you are certain to find at least one opinion you agree with, s available here.

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People who think about this stuff don't think bad online behavior will get better any time soon - Nieman Journalism Lab at Harvard