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Goods Genetics Are Key To Surviving Niche’s Harsh Worlds – Siliconera

By Joel Couture . March 8, 2017 . 2:00pm

Predators, harsh elements, and bad breeding will make quick work of careless players inNiche, a turn-based strategy game about helping animals survive in the wild.

In Niche, players will have to manage animals with a random set of genetic traits, playing to their strengths and dealing with their weaknesses as they try to survive in various environments. To do so, players will need to decide what actions to give each member of their pack on each turn, sending them out for food, digging shelters, having them mate and give birth to offspring, or attack predators.

Each turn counts as a day in the life of each animal, and after a set amount of time, each of these animals will quickly die. Death can be sped up significantly by hunger, sickness, and attacks, so players will have to deal with these issues quickly before they cut through their packs lifespan.

Players can boost their chances of survival through smart breeding. Each genetic trait can be passed on through the use of dominant-recessive genes, letting players put scientific knowledge to use, or learn more about the science of genetics through the game. In doing so, they can get rid of negative traits and boost positive ones using real science.

Niche is available now on Steam Early Access.

Video game stories from other sites on the web. These links leave Siliconera.

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Goods Genetics Are Key To Surviving Niche's Harsh Worlds - Siliconera

Performance Genetics Offering Breeze-Ups Analytics – BloodHorse.com (press release) (registration) (blog)

Performance Genetics LLC, a leading Thoroughbred analytics and performance evaluation company is pleased to announce the launch of its two-year-old in training sale site BreezeUpIQ.com BreezeUpIQ.com uses the latest in machine learning algorithms, specifically XGBoost, to develop a predictive algorithm to select elite horses from two-year-olds in training sales. More than half of the winning solutions in machine learning challenges hosted at data science platform Kaggle adopt XGBoost as their winning algorithm. "This project is the culmination of years of work, gathering data at major two-year-olds in training sales across North America and Europe and using racetrack outcomes to develop a predictive algorithm for two-year-olds in training sales. In all, I have data on just over 6,000 horses that subsequently had 3 or more starts so are valid records to create a prediction algorithm on," said Byron Rogers of Performance Genetics. "The algorithm normalizes a breeze and gallop out for the sex and distance breezed and using other variables such as velocity, decay, stride length and strides per second it is able to capture both linear and non-linear relationships in the data to elite performance making it a unique player in the two-year-olds sales market", Rogers added. In a randomized holdout set of 1,000 two-year-olds with racing outcomes that the algorithm had not seen before, the BreezeUpIQ XGBoost model selected just 6.8% of all horses, with 23.1% of these being subsequent stakes winners. "The model doesn't find every stakes winner, as some stakes winners will for one reason or another generate breeze data that is not different to a lot of average horses, but it delivers an outstanding strike rate for selecting elite runners at two-year-olds in training sales for the relatively small number horses that it does identify as being unique. Importantly it is learning off new data every month to become more and more precise," said Rogers. Current plans will see the algorithm used at the upcoming OBS March 2YO sale and major two-year-olds sales in North America with plans to roll out the service at European two-year-olds sales this year. For further information please contact, Byron Rogers Performance Genetics LLC e: byron@performancegenetics.com m: +1 859 285 0431

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Performance Genetics Offering Breeze-Ups Analytics - BloodHorse.com (press release) (registration) (blog)

Rhine speaks on genetics – The Hillsdale Daily News

By The Hillsdale Daily News

JACKSON Students and community members are invited to learn the latest advances in genetics research when the noted speaker and educator Sam Rhine presents a Genetics Update Conference from 9 a.m. to 12:30 p.m. March 14 in the Harold Sheffer Music Hall, Potter Center.

Over the years, Rhine has spoken to tens of thousands of students and teachers about genetics research. High school and college students who attend Rhines conference are often enrolled in biology or Advanced Placement biology classes, are college bound, in college or in pre-professional tracks like medicine, life sciences or social studies. Every presentation begins with a review of the basics, so less experienced students need not worry about being lost. Students have a unique chance to hear one of the top educators in the country present the most recent genetics information. This years conference will cover Human Embryology Basis of Stem Cell Biology, CRISPR-Cas9 Applications of Genome Editing, and more. In addition to the biologic and medical applications, the conference will also review the ethical issues raised by this work.

Sam Rhine has crossed the country for 30-plus years presenting the latest genetic information to students and teachers. Sam has devoted himself to genetics education. He is a gifted speaker with the desire to take biology out of the textbook and see how it works in the real world.

Admission to the Sam Rhine Genetic Update Conference is $20 per person for students, teachers and community guests. Jackson College faculty and students, including dual-enrolled high school students, are free with student ID or class schedule. Please pre-register online at http://www.samrhine.com.

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Rhine speaks on genetics - The Hillsdale Daily News

Researchers Engineer Enforcer Cells That Will Take out Lethal Bacteria – Big Think

Bacteria and antibiotics have been in an arms race since the drugs were invented. But for economic reasons, fewer and fewer of these drugs are being developed today, while the fear of antibiotic-resistant bacteria is ever-growing. This, and the potential threat of a bioterror attack, where say an epidemic-causing bacteria is released into the general population, makes the need for countermeasures obvious. Johns Hopkins researchers have come up with a new way to eliminate dangerous bacteria, using beefed up cells who seek out and destroy dangerous pathogens, all on their own.

Researchers from the John Hopkins Whiting School of Engineering and the School of Medicine teamed up on this four-year project. They received a grant of $5.7 million, awarded by the federal agency DARPA (Defense Advanced Research Projects Agency). The point of the study is to create a biocontrol system that can send out single-cell enforcers to find and eliminate certain pathogens. Researchers will program amoeba cells to do so, each one micron long, about one-tenth the width of a human hair.

These amoeba are independent and travel on their own surfaces--meaning they can get potentially deadly pathogens wherever they may be. In the event they are needed, they would be emitted through a spray. As a first step, scientists hope to program the cells to go after the bacteria which causes Legionnaires disease.

It could also be used to target Pseudomonas aeruginosa, a dangerous, potentially deadly, treatment-resistant strain of pneumonia. In another scenario, specially engineered amoeba cells are unleashed by health officials if an outbreak occurs. There are other uses too. They could sterilize instruments, and studying them may even reap benefits for cancer research.

So whats DARPAs interest? These biochemical warriors may someday help dampen down or even counteract a bioterror attack. They could also be used to render contaminated soil harmless. The innovation here is that each cellular soldier is self-directed. It does not depend on an outside human operator. Principal investigator Pablo A. Iglesias likened it to a self-driving car. Iglesias is a professor of electrical and computer engineering at Johns Hopkins.

Amoebas.By C.G. Ehrenberg (Die Infusionthierchen, 1830) [Public domain], via Wikimedia Commons

Just as cruise control slows down or speeds up a car, Iglesias said, In a similar way, the biocontrol systems were developing must be able to sense where the pathogens are, move their cells toward the bacterial targets, and then engulf them to prevent infections among people who might otherwise be exposed to the harmful microbes.

Iglesias started looking into biocontrol systems 15 years ago. To develop this particular type of synthetic biology, he is teaming up with four colleagues at the school of medicine. Each is a biological chemistry expert. Douglas N. Robinson, a professor of cell biology is on the team. He likened what these amoebas do to bacteria to what humans do when they encounter freshly baked cookies. They seek to gorge themselves unabashedly.

Though the technique has a lot of potential, Iglesias admitted to the Baltimore Sun, that past experiments in the field havent actually gone very well. "People manage to do things but it takes huge amounts of effort and it's more or less random, he said. There has to be a lot of iterations before it works." Other experts say, this teams efforts are heartening, particularly due to the growing menace of antibiotic-resistant bacteria.

Researchers are using amoeba cells called Dictyostelium discoideum in their experiments. This species is commonly studied. It can be found in the damp soil of riverbeds. These microbes surround bacteria and devour them. Turns out the bacteria let off a biochemical scent that the amoeba, using a specific type of receptor, pick up.

Robinson said that their experiments must adhere to the strictest operating protocols, lest such amoeba escape into the environment and wreak havoc. If this project bears fruit, researchers believe theyll have a new tool to fight infection in hospitals, and protect society against bioterror and ecological disasters. So far, scientists are targeting only pathogens lurking outside the human body. In this contract, we are not targeting bacteria in human blood, Iglesias said. But the hope is that the techniques we develop would ultimately be useful for that.

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Researchers Engineer Enforcer Cells That Will Take out Lethal Bacteria - Big Think

In-cell NMR: A new application – Phys.Org

March 8, 2017 (a) Proteins (green) can be endogenously expressed and isotopically labelled in bacteria (b) Exogenous proteins (blue) can be delivered to X. Credit: Enrico Luchinat and Lucia Banci

The structure of biological macromolecules is critical to understanding their function, mode of interaction and relationship with their neighbours, and how physiological processes are altered by mutations or changes in the molecular environment.

Ideally, classical structural biology research should interface more with cellular biology, as it is crucial for the structural data obtained in vitro to be validated within the cellular or tissue context. A true cellular structural biology approach should allow macromolecules to be characterised directly in their native environment. Such an approach would guarantee the high significance of data obtained in vivo or in the cell with the high resolution of a structural technique.

In the Past decade, NMR spectroscopy has been applied to obtain structural and functional information on biological macromolecules inside intact, living cells. The approach, termed "in-cell NMR", utilises the improved resolution and sensitivity of modern high-field NMR spectrometers and exploits selective enrichment of the molecule(s) of interest with NMR-active isotopes.

Since its inception, in-cell NMR has gradually emerged as a possible link between structural and cellular approaches. Being especially suited to investigate the structure and dynamics of macromolecules at atomic resolution, in-cell NMR can fill a critical gap between in vitro-oriented structural techniques such as NMR spectroscopy, X-ray crystallography and single-particle cryo-EM techniques and ultrahigh-resolution cellular imaging techniques, such as cryo-electron tomography.

In a topical review IUCrJ (2017), 4, 108-118 Lucia Banci and her co-worker Enrico Luchinat , both based at the University of Florence, summarise the major advances of in-cell NMR and report the recent developments in the field, with particular focus on its application for studying proteins in eukaryotic and mammalian cells and on the development of cellular solid-state NMR.

Explore further: Catching a glimpse at enzymes on the job

More information: Enrico Luchinat et al, In-cell NMR: a topical review, IUCrJ (2017). DOI: 10.1107/S2052252516020625

AAA+ ATPases are a large family of ubiquitous enzymes with multiple tasks, including the remodelling of the cellular proteome, i.e. the ensemble of proteins in a biological cell. A subfamily, so-called unfoldases, recognize, ...

A team of scientists from MIPT, Research Center Jlich (Germany), and Institut de Biologie Structurale (France) has developed a new approach to membrane protein crystallization. For the first time, the scientists have showed ...

Currently, biologists who study the function of protein nanomachines isolate these complexes outside the cell in test tubes, and then apply in vitro techniques that allow them to observe their structure down to the atomic ...

Using 3-D electron microscopy, structural biologists from the University of Zurich succeeded in elucidating the architecture of the lamina of the cell nucleus at molecular resolution for the first time. This scaffold stabilizes ...

The first three-dimensional (3-D) structure of a human protein complex within intact mammalian cells has been obtained directly by A*STAR scientists. It could provide new opportunities in structural biology, in developing ...

A new study shows that it is possible to use an imaging technique called cryo-electron microscopy (cryo-EM) to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells. The cryo-EM ...

The International Potato Center (CIP) launched a series of experiments to discover if potatoes can grow under Mars atmospheric conditions and thereby prove they are also able to grow in extreme climates on Earth. This Phase ...

EPFL scientists have carried out a genomic and evolutionary study of a large and enigmatic family of human proteins, to demonstrate that it is responsible for harnessing the millions of transposable elements in the human ...

An international research team has discovered a biochemical pathway that is responsible for the development of moss cuticles. These waxy coverings of epidermal cells are the outer layer of plants and protect them from water ...

A new study involving biologists from Monash University Australia has found that despite their very different ancestors, dolphins and crocodiles evolved similarly-shaped skulls to feed on similar prey.

A new study by G. William Arends Professor of Microbiology at the University of Illinois Bill Metcalf with postdoctoral Fellow Dipti Nayak has documented the use of CRISPR-Cas9 mediated genome editing in the third domain ...

Proteins, those basic components of cells and tissues, carry out many biological functions by working with partners in networks. The dynamic nature of these networks - where proteins interact with different partners at different ...

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McGill third-best in the world for anatomy, sixth for mining – McGill Reporter

Browse > Home / Headline News / McGill third-best in the world for anatomy, sixth for mining

Posted on Tuesday, March 7, 2017

By McGill Reporter Staff

McGill just keeps getting better. Thats the conclusion to be drawn from the latest QS World University Rankings by Subject released on March 8, 2017.

From a stunning third-place ranking for the Universitys program in anatomy and physiology (only Oxford and Cambridge were better) to a sixth-place rank for Mining and Metals Engineering, McGill had 32 subjects ranked in the Top 50 in the world and posted 23 improvements since last year, against only 12 declines and 10 subjects where the ranking didnt change.

The seventh edition of Quacquarelli Symondss analysis of subject-specific university performance lists the worlds best universities for the study of 46 different subjects. Anatomy & Physiology is one of four new subject categories introduced in this years listing.

We are extremely pleased to rank among the worlds top three universities in the study of anatomy and physiology, said David Eidelman, Vice-Principal of Health Affairs and Dean of Medicine at McGill. This is a direct outcome of the quality of our academics and staff in these departments, who I congratulate for their stellar and hard work on behalf of our students. I am also gratified to see McGills rankings rise this year in the medicine and pharmacology categories.

Dean of Engineering Jim Nicell was equally delighted with the results in Mining and Metals. We are very proud to be ranked so highly along with our counterparts in other Canadian institutions, he said. The mining industry is an essential part of the economy of Canada, so we must always do our best to stay at the forefront in our teaching and research in support of this sector.

McGills ranking in the Medicine subject category rose from 27th in 2016 to 22nd in the latest edition. In Pharmacology, McGill moved up to the 31st spot from 37th a year ago.

McGill was ranked in five subject areas and placed in the Top 50 in four of them Medicine (28), Arts & Humanities (43), Natural Sciences (46) and Social Sciences & Management (49). McGill ranked 63rd in Engineering.

QS evaluated 4,438 universities,qualified 3,098 and ranked 1,117 institutions in total. More than 127 million citations attributions were analyzed and the British firm verified the provision of more than 18,900 programs. This years QS rankings by subject feature a record 46 subjects, four more than the previous year.

McGill University now features amongst the worlds elite institutions in 40 of the 46 subjects and all five subject areas featured in this yearsQS World University Rankings by Subject, said Ben Sowter, Head of Division for the QS Intelligence Unit.

The University is currently ranked 30th globally by QS, among the almost 1,000 universities surveyed for the annual report of world university rankings. McGill has been ranked as the top Canadian university for 11 of the 13 years that the QS/THE rankings have been published, apart from 2013 and 2014.

The full QS World University Rankings by Subject tables can be foundonline. The full methodology can be foundhere.

Category: Headline News

Tag: QS World University Rankings by Subject, Quacquarelli Symonds

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McGill third-best in the world for anatomy, sixth for mining - McGill Reporter

Greys Anatomy New Episode 15 Spoilers Meredith Back – Refinery29 – Refinery29

Whether you're feeling Meredith Grey (Ellen Pompeo) and Nathan Riggs (Martin Henderson) or not I mean, will we ever really get over Meredith and Derek's (Patrick Dempsey) ultimate love story? there's no way Meredith can deny that she's into the doc. He may not be McDreamy, but he's certainly, well, dreamy and always down to push Mer's buttons. Not that Meredith is any sort of pushover: the doctor was suspended from Grey Sloan Memorial Hospital when she refused to let Eliza Mennick (Marika Dominczyk) into her operating room. Meredith's insubordination may have gotten her booted from her own OR, but now she's back at the request of Dr. Richard Webber (James Pickens Jr.). And Nathan has something to say about it.

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Greys Anatomy New Episode 15 Spoilers Meredith Back - Refinery29 - Refinery29

Anatomy of a record-setting Top Fuel run – Motor Authority

Unless you've ridden on top of 11,000 horsepower, Leah Pritchett has more stones than anyone one of us. She's a Top Fuel dragster driver and she holds the record for the fastest pass in NHRA history with a 3.658 run over the 1,000-foot distance at the NHRA Arizona Nationals. She set that record on February 24 at Wild Horse Pass Motorsports Park in Chandler, Arizona.

Ken Block's Hoonigan crew happened to be on hand at the event to capture the action and produce the video above.

The video goes through all of the stages of prep: From suiting up, to climbing on board, to buckling in, to connecting the communications equipment, to reaction time practice.

That reaction time practice session apparently shows a slight that is quickly dealt with during a system check.

ALSO SEE: Why can't production cars reach 300 mph?

Next, it's time to pre-stage the car, wet down the tires in preparation for a burnout, prime that monster engine to start it, then fire it up.

Now the fun stuff begins. Leah nails the throttle and does a burnout through the starting line. She backs it up, her crew scrubs the pebbles off the tires, and she gets ready for the run.

That means checking the fuel, releasing the clutch pack, staging it, watching the tree, releasing the brake, and, BOOM, going like a bat out of hell.

The video shows plenty of countersteer on the tiny steering wheel and not a ton of visibility out of the fuselage-like cockpit.

In the end, we see a heck of a pass, but it may not be the 3.658 at 329.34 mph that set the record. It sounds like one of her crew says 67-7, which would indicate a 3.677 run, just off the pace from that record run.

No matter how fast she went, this video gives us a good idea of what the Top Fuel experience is like. Of course, video can't convey the emotional and crazy physical elements of this type of racing. The sound is louder than anything you've ever heard, and the feeling of the g forces hitting your body, well, maybe an astronaut could relate but few others could.

Still, this video is worth a watch, if nothing else to see how much cooler Leah Pritchett is than the rest of us.

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Anatomy of a record-setting Top Fuel run - Motor Authority

Genetics may influence outcome of efforts to promote maternal attachment – PLOS Research News

Secure attachment between mother and infant boosts childrens social, emotional and physical development. Many studies have investigated ways to strengthen maternal-infant attachment and how to implement these strategies for maximum effect, particularly in low- and middle-income countries. But few have asked whether genetics can explain why some children are more likely to benefit than others.

In a new study, Barak Morgan at the University of Cape Town in South Africa and colleagues tested whether a genetic polymorphism of the serotonin transporter gene affects maternal-infant attachment. They reanalyzed data from a previous study that showed that home visits from a parenting program called Thula Sana promoted secure maternal-infant attachment in a low-income community in South Africa. Morgans team used the genetic data collected from approximately half of those who participated in the original trial when they were 13 years of age to compare attachment rates for participants with different polymorphisms of the serotonin transporter gene.

The scientists found that the short allele of the serotonin transporter gene may indeed explain why some infants were more likely than others to form strong attachments with their mothers after the home visits. The probability of forming a secure attachment depended on each childs specific versions, or alleles, of the serotonin transporter gene.

For children whose DNA carried one or two copies of the short allele of the serotonin transporter gene, Thula Sana proved highly effective at improving rates of secure infant attachment. Eighty four percent of children with the short allele formed secure attachment after the program, versus just 58 percent of children with the short allele who did not receive home visits.

Children with two copies of the long allele of the serotonin transporter gene, showed no measurable benefit from the home visits. For these children, the probability of secure maternal-infant attachment was 71 percent if the family received home visits and 70 percent if they did not receive the intervention.

The authors note that past research has operated under the belief that maternal attachment programs such as Thula Sana as well as other strategies to improve early childhood development benefit all children equally. The results of this study challenge this assumption, and indicate that the success of such strategies can vary from child to child and is influenced in part by the genetic polymorphism of the serotonin transporter gene.

The authors call for additional research investigating the interactions between genetics and psychosocial strategies that promote early childhood development. Such research could inform global health policy, which is focused intently on strengthening early childhood development to mitigate the harmful effects of poverty.

Research Article: Morgan B, Kumsta R, Fearon P, Moser D, Skeen S, Cooper P, et al. (2017) Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial. PLoS Med 14(2): e1002237. doi:10.1371/journal.pmed.1002237

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Genetics may influence outcome of efforts to promote maternal attachment - PLOS Research News

Tennessee bird flu shares name, not genetics, of feared China strain: USDA – Reuters

By Tom Polansek | CHICAGO

CHICAGO The strain of bird flu that infected a chicken farm in Tennessee in recent days shares the same name as a form of the virus that has killed humans in China, but is genetically distinct from it, U.S. authorities said on Tuesday.

The U.S. Department of Agriculture identified the strain in Tennessee as H7N9, following a full genome sequencing of samples from the farm. It said all eight gene segments of the virus had North American wild bird lineage.

On Sunday, the USDA confirmed the farm in Tennessee was infected with highly pathogenic bird flu, making it the first case in a commercial U.S. operation in more than a year.

In China, at least 112 people have died from H7N9 bird flu this winter, Xinhua news agency said on Friday.

However, that virus has Eurasian lineage, U.S. flu experts said.

"Even though the numbers and the letters are the same, if you look at the genetic fingerprint of that virus, it is different," said Dan Jernigan, director of the influenza division at the National Center for Immunization and Respiratory Diseases at U.S. Centers for Disease Control and Prevention.

Jernigan said the risk to humans from the virus found in Tennessee is low. Genome sequencing shows the H7N9 virus did not have genetic features present in the virus in China that make it easier for humans to become infected, he said.

The virus found in Tennessee likely mutated to become highly pathogenic from a less dangerous, low pathogenic form, he said.

Disease experts fear a deadly strain of bird flu could mutate into a form that could be passed easily between people and become a pandemic.

Multiple outbreaks of the virus have been reported in poultry farms and wild flocks across Europe, Africa and Asia in the past six months. Most involved strains that were low risks for human health, but the sheer number of different types, and their simultaneous presence in so many parts of the world, has increased the risk of viruses mixing and mutating - and possibly jumping to people, according to disease experts.

China's Center for Disease Control and Prevention has said the majority of people infected by H7N9 in China reported exposure to poultry, especially at live markets.

Identifying the viruses in Tennessee and China both as H7N9 is similar to having two cars from different states with the same license plate number, said Carol Cardona, avian flu expert at the University of Minnesota.

The strain in Tennessee "is NOT the same as the China H7N9 virus that has impacted poultry and infected humans in Asia," the USDA emphasized in a statement.

"While the subtype is the same as the China H7N9 lineage that emerged in 2013, this is a different virus and is genetically distinct from the China H7N9 lineage," the USDA added.

U.S. officials are working to determine how the Tennessee farm, which was a supplier to Tyson Foods Inc, became infected. All 73,500 birds there were killed by the disease or suffocated with foam to prevent its spread.

Tyson, the world's biggest chicken company, is "hopeful this is an isolated incident," spokesman Worth Sparkman said.

Authorities have not identified the name of the farm or the town in Lincoln County, Tennessee, where it is located.

(Editing by Matthew Lewis and Bernard Orr)

WASHINGTON Health and Human Services Secretary Tom Price said on Tuesday that President Donald Trump supports the Republican bill to replace Obamacare.

SEOUL South Korea has culled some 50,000 farm birds as two cases of bird flu were confirmed on Wednesday, bringing the country's cull this winter to nearly 35 million - more than a fifth of all South Korean poultry - since a first bird flu case was found late last year.

(Reuters Health) - Genetic changes in the cells lining the inside of the nose might someday help doctors diagnose lung cancer, a recent study suggests.

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Tennessee bird flu shares name, not genetics, of feared China strain: USDA - Reuters