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Sociologists urge use of big data to study human interaction … – Stanford University News

The internet dominates our world and each one of us is leaving a larger digital footprint as more time passes. Those footprints are ripe for studying, experts say.

A new paper urges sociologists and social psychologists to focus on developing online research studies with the help of big data to advance theories of social interaction and structure. (Image credit: pixelfit / Getty Images)

In a recently published paper, a group of Stanford sociology experts encourage other sociologists and social psychologists to focus on developing online research studies with the help of big data in order to advance the theories of social interaction and structure.

Companies have long used information they gather about their online customers to get insights into performance of their products, a process called A/B testing. Researchers in other fields, such as computer science, have also been taking advantage of the growing amount of data.

But the standard for many experiments on social interactions remains limited to face-to-face laboratory studies, said Paolo Parigi, a lead author of the study, titled Online Field Experiments: Studying Social Interactions in Context.

Parigi, along with co-authors Karen Cook, a professor of sociology, and Jessica Santana, a graduate student in sociology, are urging more sociology researchers to take advantage of the internet.

What I think is exciting is that we now have data on interactions to a level of precision that was unthinkable 20 years ago, said Parigi, who is also an adjunct professor in the Department of Civil and Environmental Engineering.

In the new study, the researchers make a case for online field experiments that could be embedded within the structure of existing communities on the internet.

The researchers differentiate online field experiments from online lab experiments, which create a controlled online situation instead of using preexisting environments that have engaged participants.

In their new study, sociology Professor Karen Cook and her co-authors make a case for online field experiments that could be embedded within the structure of existing communities on the internet. (Image credit: L.A. Cicero)

The internet is not just another mechanism for recruiting more subjects, Parigi said. There is now space for what we call computational social sciences that lies at the intersection of sociology, psychology, computer science and other technical sciences, through which we can try to understand human behavior as it is shaped and illuminated by online platforms.

As part of this type of experiment, researchers would utilize online platforms to take advantage of big data and predictive algorithms. Recruiting and retaining participants for such field studies is therefore more challenging and time-consuming because of the need for a close partnership with the platforms.

But online field experiments allow researchers to gain an enhanced look at certain human behaviors that cannot be replicated in a laboratory environment, the researchers said.

For example, theories about how and why people trust each other can be better examined in the online environments, the researchers said, because the context of different complex social relationships is recorded. In laboratory experiments, researchers can only isolate the type of trust that occurs between strangers, which is called thin trust.

Most recently, Cook and Parigi have used the field experiment design to research the development of trust in online sharing communities, such as Airbnb, a home and room rental service. The results of the study are scheduled to be published later this year. More information about that experiment is available at stanfordexchange.org.

Its a new social world out there, Cook said, and it keeps expanding.

Using big data does come with a greater need for ethical responsibility. In order for the online studies of social interactions to be as accurate as possible, researchers require access to private information for their participants.

One solution that protects participants privacy is linking their information, such as names or email addresses, to unique identifiers, which could be a set of letters or numbers assigned to each research subject. The administrators of the platform would then provide those identifiers to researchers without compromising privacy.

Its also important to make sure researchers acquire the permission of the online platforms participants. Transparency is key in those situations, Cook said.

The research was funded by the National Science Foundation.

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Sociologists urge use of big data to study human interaction ... - Stanford University News

A psychologist, dog poop and human behavior – Albany Times Union

Dr. Allen Carl walks Nellie, a border collie mix, while his wife, Susan Ross, carries Stanley the Maltese in a sling on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union) less Dr. Allen Carl walks Nellie, a border collie mix, while his wife, Susan Ross, carries Stanley the Maltese in a sling on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times ... more

Dr. Allen Carl holds a roll of dog poop plastic bags on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Dr. Allen Carl holds a roll of dog poop plastic bags on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Dana Graupe poses with Monty, a 3-year-old St. Bernard mix, on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Dana Graupe poses with Monty, a 3-year-old St. Bernard mix, on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Stanley, a Maltese, in her preferred transportation mode, a dog sling carried by Susan Ross, on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Stanley, a Maltese, in her preferred transportation mode, a dog sling carried by Susan Ross, on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Susan Ross with Stanley, a Maltese, in his dog sling, where he falls asleep and snores on walks on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Susan Ross with Stanley, a Maltese, in his dog sling, where he falls asleep and snores on walks on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Susan Ross and her dogs Nellie and Stanley (in sling) meet Dana Graupe and her dog, Monty, on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Susan Ross and her dogs Nellie and Stanley (in sling) meet Dana Graupe and her dog, Monty, on Sunday, April 2, 2017, in Albany's Washington Park. (Paul Grondahl/Special to the Times Union)

Roxie, Stella and Grace from the French bulldog-Boston terrier page on AlbanyDogs.net (Photo by Michael Kalin)

Roxie, Stella and Grace from the French bulldog-Boston terrier page on AlbanyDogs.net (Photo by Michael Kalin)

Caroline and Daisy, best companions for 14 years. (Caroline Grondahl)

Caroline and Daisy, best companions for 14 years. (Caroline Grondahl)

Caroline Grondahl on her 4th birthday, when she got Daisy as a surprise birthday present. (Paul Grondahl)

Caroline Grondahl on her 4th birthday, when she got Daisy as a surprise birthday present. (Paul Grondahl)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Daisy, an Australian shepherd mix (Photo couresy of Jake Dillon)

Max, a jumbo-sized Shetland sheepdog (Photo courtesy of Norma Chepaitis Shook)

Max, a jumbo-sized Shetland sheepdog (Photo courtesy of Norma Chepaitis Shook)

Max, a jumbo-sized Shetland sheepdog (Photo courtesy of Norma Chepaitis Shook)

Max, a jumbo-sized Shetland sheepdog (Photo courtesy of Norma Chepaitis Shook)

The best memory with Willow, a service dog at Pine Bush Elementary School (Drawing by Sanjana Stephen)

The best memory with Willow, a service dog at Pine Bush Elementary School (Drawing by Sanjana Stephen)

Micah the yellow Lab (Photo courtesy of Sue Raynis)

Micah the yellow Lab (Photo courtesy of Sue Raynis)

Micah the yellow Lab (Photo courtesy of Sue Raynis)

Micah the yellow Lab (Photo courtesy of Sue Raynis)

Minnie the shepherd mix on the dog bed she hated. (Photo courtesy of Claire Lynch)

Minnie the shepherd mix on the dog bed she hated. (Photo courtesy of Claire Lynch)

Minnie, a shepherd mix, enjoying Washington Park in Albany. (Photo courtesy of Claire Lynch)

Minnie, a shepherd mix, enjoying Washington Park in Albany. (Photo courtesy of Claire Lynch)

Jake the beagle with Kim Kendrick's son Michael. (Photo courtesy of Kim Kendrick)

Jake the beagle with Kim Kendrick's son Michael. (Photo courtesy of Kim Kendrick)

Tucker the cocker spaniel (Drawing by Conner Len)

Tucker the cocker spaniel (Drawing by Conner Len)

Bandit, a dog who thinks he's a cat. (Drawing by Lauren, a 5th grader at Pine Bush Elementary School)

Bandit, a dog who thinks he's a cat. (Drawing by Lauren, a 5th grader at Pine Bush Elementary School)

Gerty, my funny puppy (Drawing by Erika Para)

Gerty, my funny puppy (Drawing by Erika Para)

Gerty the Funny Puppy (Drawing by Erika, a 5th grader at Pine Bush Elementary School)

Gerty the Funny Puppy (Drawing by Erika, a 5th grader at Pine Bush Elementary School)

Precious, a cocker spaniel who lived up to her name. (Photo by Ed DerGurahian)

Precious, a cocker spaniel who lived up to her name. (Photo by Ed DerGurahian)

Precious, a beloved cocker spaniel and faithful companion. (Photo by Ed DerGurahian)

Precious, a beloved cocker spaniel and faithful companion. (Photo by Ed DerGurahian)

Kosmo the Sheltie was named after Cosmo Kramer of Seinfeld show fame (Photo courtesy of Dianne L. Patterson)

Kosmo the Sheltie was named after Cosmo Kramer of Seinfeld show fame (Photo courtesy of Dianne L. Patterson)

Kosmo the Sheltie was named after Cosmo Kramer of Seinfeld show fame (Photo courtesy of Dianne L. Patterson)

Kosmo the Sheltie was named after Cosmo Kramer of Seinfeld show fame (Photo courtesy of Dianne L. Patterson)

Raymond G. Shepherd as a young dog. (Photo courtesy of Dan Doyle)

Raymond G. Shepherd as a young dog. (Photo courtesy of Dan Doyle)

Raymond G. Shepherd at Lake Harris (Photo courtesy of Dan Doyle)

Raymond G. Shepherd at Lake Harris (Photo courtesy of Dan Doyle)

Red "The Houndicorn," a bloodhound. (Photo courtesy of Shelby Cady)

Red "The Houndicorn," a bloodhound. (Photo courtesy of Shelby Cady)

Red "The Houndicorn," a bloodhound. (Photo courtesy of Shelby Cady) ORG XMIT: Gf9lqfJtNms_KWVN14GS

Red "The Houndicorn," a bloodhound. (Photo courtesy of Shelby Cady) ORG XMIT: Gf9lqfJtNms_KWVN14GS

John Runfola's dog, Sailor Bob. (Courtesy John Runfola)

John Runfola's dog, Sailor Bob. (Courtesy John Runfola)

John Runfola's dog, Sailor Bob. (Courtesy John Runfola)

John Runfola's dog, Sailor Bob. (Courtesy John Runfola)

Scamp, a Schnoodle -- Schnauzer and poodle cross -- meets some children at Dr. Jonathan Pasternack's Delmar pediatric office. (Photo courtesy of Lois Pasternack)

Scamp, a Schnoodle -- Schnauzer and poodle cross -- meets some children at Dr. Jonathan Pasternack's Delmar pediatric office. (Photo courtesy of Lois Pasternack)

Lois Pasternack with Scamp, her Schnoodle. (Photo courtesy of Lois Pasternack)

Lois Pasternack with Scamp, her Schnoodle. (Photo courtesy of Lois Pasternack)

Maxwell, a black Lab/spaniel mix. (Photo courtesy of Connie Jo Fedorwich)

Maxwell, a black Lab/spaniel mix. (Photo courtesy of Connie Jo Fedorwich)

Maxwell, a black Lab/spaniel mix. (Photo courtesy of Connie Jo Fedorwich)

Maxwell, a black Lab/spaniel mix. (Photo courtesy of Connie Jo Fedorwich)

Simba, a Lab/chow mix (Photo courtesy of Clare Mertz)

Simba, a Lab/chow mix (Photo courtesy of Clare Mertz)

Clockwise from top, Jack Huber, Sunny and Julia Huber, at their home in Delmar in 2008.

Clockwise from top, Jack Huber, Sunny and Julia Huber, at their home in Delmar in 2008.

Jack Huber and Sunny, who can barely keep his eyes open, at their home in Delmar in 2007.

Jack Huber and Sunny, who can barely keep his eyes open, at their home in Delmar in 2007.

Julia Huber and Sunny at their home in Delmar in 2008.

Julia Huber and Sunny at their home in Delmar in 2008.

Syliva the bull terrier (Photo courtesy of Mark Schaming)

Syliva the bull terrier (Photo courtesy of Mark Schaming)

Kaiser Von Buckingham Streeter, the "King of Buckingham," after the Albany neighborhood pond. (Photo courtesy of Elmer Streeter)

Kaiser Von Buckingham Streeter, the "King of Buckingham," after the Albany neighborhood pond. (Photo courtesy of Elmer Streeter)

Rudy the beagle with a Stewart's milk carton (Photo courtesy of Gina Giuliano)

Rudy the beagle with a Stewart's milk carton (Photo courtesy of Gina Giuliano)

Rudy the beagle as a puppy (Photo courtesy of Gina Giuliano)

Rudy the beagle as a puppy (Photo courtesy of Gina Giuliano)

Nellie Bly, a black Lab mix (Photo courtesy of Holly McKenna)

Nellie Bly, a black Lab mix (Photo courtesy of Holly McKenna)

Nellie Bly, a black Lab mix (Photo courtesy of Holly McKenna)

Nellie Bly, a black Lab mix (Photo courtesy of Holly McKenna)

Daisy, Maggie and Kalie the German shorthaired pointers (Photos courtesy of Renee Pizzo-Roy)

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A psychologist, dog poop and human behavior - Albany Times Union

NewLink Genetics Corporation (NLNK) Plunges 14% on April 05 – Equities.com

Market Summary Follow

NewLink Genetics Corporation is a A biopharmaceutical company

NLNK - Market Data & News

NLNK - Stock Valuation Report

NewLink Genetics Corporation (NLNK) had a rough trading day for Wednesday April 05 as shares tumbled 14%, or a loss of $-2.91 per share, to close at $17.88. After opening the day at $20.79, shares of NewLink Genetics Corporation traded as high as $20.79 and as low as $17.84. Volume was 2.26 million shares over 14,772 trades, against an average daily volume of 371,077 shares and a total float of 29.22 million.

As a result of the decline, NewLink Genetics Corporation now has a market cap of $522.44 million. In the last year, shares of NewLink Genetics Corporation have traded between a range of $25.17 and $9.23, and its 50-day SMA is currently $17.33 and 200-day SMA is $13.09.

For a complete fundamental analysis of NewLink Genetics Corporation, check out Equities.coms Stock Valuation Analysis report for NLNK.

Want to invest with the experts? Subscribe to Equities Premium newsletters today! Visit http://www.equitiespremium.com/ to learn more about Guild Investments Market Commentary and Adam Sarhans Find Leading Stocks today.

NewLink Genetics Corp is a biopharmaceutical company. The Company is focused on discovering, developing and commercializing immunotherapeutic products to improve treatment options for patients with cancer.

NewLink Genetics Corporation is based out of Ames, IA and has some 122 employees. Its CEO is Charles J. Link.

NewLink Genetics Corporation is a component of the Russell 2000. The Russell 2000 is one of the leading indices tracking small-cap companies in the United States. It's maintained by Russell Investments, an industry leader in creating and maintaining indices, and consists of the smallest 2000 stocks from the broader Russell 3000 index.

Russell's indices differ from traditional indices like the Dow Jones Industrial Average (DJIA) or S&P 500, whose members are selected by committee, because they base membership entirely on an objective, rules based methodology. The 3,000 largest companies by market cap make up the Russell 3000, with the 2,000 smaller companies making up the Russell 2000. It's a simple approach that gives a broad, unbiased look at the small-cap market as a whole.

To get more information on NewLink Genetics Corporation and to follow the companys latest updates, you can visit the companys profile page here: NLNKs Profile. For more news on the financial markets and emerging growth companies, be sure to visit Equities.coms Newsdesk. Also, dont forget to sign-up for our daily email newsletter to ensure you dont miss out on any of our best stories.

All data provided by QuoteMedia and was accurate as of 4:30PM ET.

DISCLOSURE: The views and opinions expressed in this article are those of the authors, and do not represent the views of equities.com. Readers should not consider statements made by the author as formal recommendations and should consult their financial advisor before making any investment decisions. To read our full disclosure, please go to: http://www.equities.com/disclaimer

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NewLink Genetics Corporation (NLNK) Plunges 14% on April 05 - Equities.com

BRIEF-Myriad Genetics, Beigene sign agreement – Reuters

April 6 Myriad Genetics Inc:

* Myriad Genetics and Beigene sign agreement to develop companion diagnostics for use with Beigene's novel parp inhibitor, BGB-290

* Myriad Genetics Inc - specific terms of deal were not disclosed.

* Myriad Genetics-under deal Beigene to use co's mychoice HRD, bracanalysis CDX companion diagnostic tests to support clinical development of BGB-290 Source text for Eikon: Further company coverage:

* Says it buys 50 percent stake in Barrick Gold's Veladero gold mine in Argentina for $960 million

* Cardiome's partner steadymed announces successful completion of trevyent clinical validation study

* Ant Financial Services Group says issued letter to Moneygram Community as it relates to Ant Financial's agreement to merge with Moneygram

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BRIEF-Myriad Genetics, Beigene sign agreement - Reuters

What is 4-H? – The Stokes News

Stokes County 4-H presented an Embryology School Enrichment program at King Elementary.

Courtesy photo

4-H is the nations largest positive youth development and youth mentoring organization, empowering six million youth people in the U.S. In partnership with 110 universities, 4-H life changing programs are research-backed and available through 4-H Clubs, camps, after school & school enrichment programs in every county and parish in the U.S.

Youth who participate in their county 4-H program focus on opportunities that involve citizenship, leadership, community service, agriculture, S.T.E.M. and much more.

Stokes County 4-H currently has seven 4-H Clubs offered in the county. Our clubs focus on topics such as agriculture and livestock, dogs, horses, shooting sports, and community awareness. For more information, to become involved please contact Taylor Furr at 336-593-8179.

Stokes County 4-H provides Summer Fun educational classes beginning June 13th until August 11th. Summer Fun activities include: Zip Lining, Horsemanship Camp, Dog Camp, Cake Decorating, Canvas Painting, Popcorn Farm Tour, Robotics, Crime Scene Investigation and many more. Summer sign-ups will be distributed to the schools beginning the week of April 17.

Stokes County 4-H just wrapped up a round of the 4-H Embryology School Enrichment program at King Elementary and London Elementary. We had seven classes at King Elementary participate and two classes at London Elementary participate. Another round of this program will begin after Spring Break, April 19th, in the schools of Germanton Elementary, Pine Hall Elementary, and King Elementary. 4-H Embryology provides great exposure to the students and teachers of the life cycle of chickens. The classes house eggs for three weeks in incubators and on the 21st day on incubation, they watch the eggs hatch into baby chicks.

For more information on the Stokes County 4-H Program, please contact Taylor Furr at [emailprotected] or 336-593-8179.

Stokes County 4-H presented an Embryology School Enrichment program at King Elementary.

http://thestokesnews.com/wp-content/uploads/2017/04/web1_-H.jpgStokes County 4-H presented an Embryology School Enrichment program at King Elementary. Courtesy photo

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What is 4-H? - The Stokes News

Evidence For Evolution (RJS) – Patheos (blog)

At the Christ and Creation conference last Friday morning Dennis Venema and Scot McKnight gave back to back talks based on their new book Adam and the Genome. The major points in 25 minutes each. Both excellent talks followed by a joint (but brief) Q&A time. Both talks were excellent and inspired many in attendance to buy the book. (Baker ran out of the supply on hand well before the afternoon sessions were over.) I am slowly working through the book, starting with the evidence for evolution in general and human evolution in particular. Whatever you think of the pathways for integrating the evidence with Christian faith, it is important to take the evidence seriously. If you are not a biologist and wonder why biologists and most other scientists find the evidence compelling, buy this book and read Denniss overview. This is an excellent introduction to a complex topic.

Analogy to Language. In Chapter 2 of the book Dennis uses several different illustrations to help the lay person understand the basic principles of evolutionary biology. None of the analogies are perfect, as Dennis makes clear, but each is helpful. We can understand elements of the evolutionary process better if we step back and consider the case of language. Consider six English versions of John 14:6:

Over the course of 1000 years there was a clear change in alphabet, spelling, and word choice. We can consider the translations above akin to fossils. They provide snapshots of various states of language. Dennis takes this example and uses it to illustrate the process of evolution.

As we know, these various translations are not instantaneous changes from one to the next. Rather, they are samples drawn at intervals from a continuous process. All along the way they remained the same language in the sense that each generation could easily understand their parents and their offspring. Over time, however, changes accumulated that gradually shifted the language. Word spellings, grammar, and pronunciations changed. Given enough time, it becomes more and more of a stretch to say the languages are the same such as Anglo-Saxon and Modern English. Despite the striking differences we see now, the process that produced them was gradual. Additionally, there is no convenient point where we can say Anglo-Saxon became Modern English; the process was a continuum.

In the same way, average characteristics of a species can shift over time. (p. 21)

No individual living in any of these times, from 990 to 1982, felt that language was evolving and yet it was. No creature observes its species evolving, yet it does.

When communities are separated, by a large body of water, a mountain range, a difficult to cross river, or mere distance, one language can gradually morph into two or three or more. In isolation, the changes are distinct. Each will retain evidence of the common ancestry, even if clearly different. But again, there is no one time when it can clearly be claimed the languages are now different. At every step in the gradual process each generation could understand both parents and children and would claim they all spoke the same language. Nonetheless, after enough time, the incremental changes add up, making the languages distinct.

This is how evolution works. Each generation is the same as its parents and as its offspring. Most effective mutations are mild, and changes accumulate gradually over many generations. Red in tooth and claw is a flawed image. Transitional forms are abundant but we only recognize them when we consider a well defined starting and ending point. Like Anglo-Saxon and Modern English. Yes, mutations that afford an advantage will accumulate, but many changes are neutral. They accumulate by chance. The pattern of accumulated changes allow us to draw conclusions regarding the evolutionary bush that led to the current diversity of life on our planet. There are fossils in our genome and the genome of other animals that point to an interconnected past.

New features develop out of old features. One of the things evolution predicts is that seldom will any feature in an evolutionary lineage be truly new. (p. 37) It is the accumulation of minor changes that lead to new features. The gradual migration of a nasal opening to the top of the head over generations produced the whales blowhole. In this case each minor variation produced an advantage for the aquatic mammal and the changes accumulated. Function can change as well, a reptilian jaw bone gradually becomes a key structure in the mammalian ear.

Denis provides a number of examples, looking at specific regions of mammalian genomes for similarities and differences, whale evolution from land dwelling tetrapod to ocean dwelling mammal, and the genes and gene remnants for the production of egg yolk.

Converging lines of evidence point to the same overall pattern paleontology, embryology, and the genome. Evolution is not a theory in trouble. It continues to be refined and developed, but the overall framework has been secure for more than a century. The genetic evidence has refined and corrected some details of the bush of life proposed on the basis of embryology or paleontology, but by and large it has confirmed prior conclusions and advanced our understanding of the evolutionary process.

Given the abundant lines of DNA evidence that support the hypothesis that humans are the product of evolution, it is no exaggeration to say that (the very, very few) trained biologists who reject common ancestry do so because of prior religious commitments, not for scientific reasons.

So where do Adam and Eve fit into this picture? In the next post on the book, we will look at the evidence for human evolution and the emergence of our species Homo sapiens.

If you wish to contact me directly, you may do so at rjs4mail[at]att.net

If interested you can subscribe to a full text feed of my posts at Musings on Science and Theology.

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Evidence For Evolution (RJS) - Patheos (blog)

Chemistry – Final PhD Seminar – Mariana Phillips – Seton Hall University News & Events

Thursday, April 6, 2017

By Nicholas Snow

The Rose Mercadante Chemistry Seminar series is pleased to present the final PhD seminar of Mariana Phillips, entitled "B7H6 Derived Peptides Trigger TNF- Dependent Immunostimulatory Activity of Lymphocytic NK92-MI Cells."

The seminar will be held at 5:45 p.m. on Tuesday April 11, 2017 in the Helen Lerner Amphitheater, McNulty Hall, Science and Technology Center, Seton Hall University. The University Community is invited.

Mariana Phillips was born in Mexico City, Mexico where she received her BSc in Food Chemistry from Universidad LaSalle, Mexico, in 1998. Phillips's academic career began as a science teacher of Physics and Chemistry, focusing particularly on developing a stimulating scientific learning environment for middle school students. Phillips relocated to the United States in 2005 with her family to pursue new scientific career goals. In 2012, she joined the Department of Chemistry and Biochemistry at Seton Hall University, to work on her PhD under the supervision of Profs. David Sabatino and Constantine Bitsaktsis. During her PhD studies, Phillips has developed methods in chemical biology for the production of novel immunstimulatory peptides. Phillips has also gained expertise in working with protein biologics, including antibody mimics for cancer-targeting immunotherapy applications. In 2015, Phillips received her MS degree in Biochemistry following her successful matriculation into the PhD program. In 2016-17, Phillips initiated a productive research collaboration with Dr. Robert Korngold at Hackensack UMC to investigate the biological properties of immunstimualtory constructs in vitro and in vivo. Taken together, Phillips accomplishments during her PhD studies have led to the generation of two publications, a book chapter currently in press, a research grant approved for funding, a travel grant award for attending the American Peptide Symposium in 2015 and more than five presentations and proceedings at local and national conferences. Phillips expects to receive her PhD in Biochemsitry in May 2017.

B7H6 has been identified as a cellular membrane protein expressed exclusively on tumor cells. Interestingly, B7H6 was found to bind selectively to NKp30, an activating receptor expressed on NK cells. B7H6:NKp30 binding stimulates NK cells' antitumor immune responses through the release of cytotoxic cytokines and chemokines, leading to tumor cell death. However, lower levels or the absence of cell surface B7H6 have correlated with the evolution of tumor resistance towards NK cells' immunosurveillance. Therefore, new B7H6 derived ligands that can bind and activate NK cells are expected to improve NK-dependent killing of resilient tumors. Towards this goal, this thesis work describes the rational design of a novel class of immunostimulatory peptides (IPs) derived from the binding site interface of B7H6:NKp30. The IPs were synthesized by conventional Fmoc solid phase peptide synthesis which also facilitated the incorporation of N-terminal fluorescein isothiocyanate (FITC) for structure-activity relationship studies. The secondary structures of the peptides were examined by CD spectroscopy which revealed versatile peptide structures which transitioned from random coil to -helical and turn-type conformations. Their biological properties were evaluated by flow cytometry, enzyme-linked immunosorbent assays (ELISAs) and cell death assays. The immunostimulatory effects of the IPs on the human NK92-MI cells were assessed by the production of TNF- alone as IFN- was undetectable. In a cell death assay, the IPs were found to be non-toxic, without any observable evidence of early or late stage apoptosis within the NK92-MI cells. Therefore, B7H6 derived peptides encompass an interesting class of ligands for activating NK cells' immune activities. The latter is a current focus of our on-going research program in cancer immunotherapy applications.

The Department of Chemistry and Biochemistry offers BS, MS and PhD degrees with specializations in all areas of chemistry. Our unique research environment, including traditional full-time students and part-time students is designed to foster collaborations with industry and colleagues in other disciplines. The Rose Mercadante Seminar Series is named for Rose Mercadante, the departmental secretary for over 40 years, in honor of our alumni, her "boys and girls".

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Chemistry - Final PhD Seminar - Mariana Phillips - Seton Hall University News & Events

Culture, Science & Faith Anatomy of a Smear Piece – Patriot Post

Thomas Gallatin Apr. 5, 2017

The Washington Post recently ran a story with the provocative headline, GOP lawmaker: The Bible says the unemployed shall not eat. The article referenced comments made during a House Agriculture Committee hearing over the Supplemental Nutrition Assistance Program (SNAP) a.k.a. food stamps. The original version of the article at least acknowledged that Rep. Jodey Arrington (R-TX) cited 2 Thessalonians 3:10 in a rebuttal to an expert witness a representative from the Jewish anti-hunger group MAZON, who made reference to a passage in Leviticus about feeding the hungry.

Yet the Washington Post didnt actually quote Arrington in its rush to indict and label him and Republicans as uncaring and out of touch with the needs of the poor at least not until later revisions were made. The article states, House Republicans have historically cited the verse if a man will not work, he shall not eat as justification for cutting some adults' SNAP benefits. Arrington referenced the verse in a discussion about increasing the work requirements for unemployed adults on the food stamp program. But critics say that advances a pernicious myth about the unemployed who receive SNAP.

The truth is it was the Washington Post that was actively attempting to advance a pernicious myth regarding both the intent and reasoning of Republicans and Rep. Arrington specifically. And they were exposed for it.

Shortly after the articles release, The Federalists Sean Davis called out the Beltway rag over its sloppy and biased reporting. Davis pointed out that the Post failed to quote Arrington and failed to properly apply the Biblical context of both Scripture references.

The Washington Post, evidently catching wind of criticism for its lackluster piece, responded by heavily editing the original article, including changing the headline to GOP lawmaker: The Bible says if a man will not work, he shall not eat, as well as adding Arringtons exact words.

Arrington said, I did hear, Mr. Protas [the MAZON representative], your opening remarks where you quoted Leviticus, I believe and I think thats a great reflection on the character of God and the compassion of Gods heart and how we ought to reflect that compassion in our lives. But theres also, you know, in the Scripture, tells us in 2 Thessalonians 3:10 he says, For even when we were with you we gave you this rule: If a man will not work, he shall not eat. And then he goes on to say, We hear that some among you are idle. I think that every American, Republican or Democrat, wants to help the neediest among us. And I think its a reasonable expectation that we have work requirements. I think that gives more credibility, quite frankly, to SNAP. Tell me, what is a reasonable and responsible work requirement as part of the SNAP program?

The Post truncates his last few sentences, but upon reading the updated and edited article, the papers dubious characterization of both Arrington and the Republicans loses credibility, showing more glaringly the articles original bias as being primarily an anti-Republican propaganda piece. So much for the Posts Democracy Dies in Darkness tripe.

This episode proves to highlight a couple of important points. First, the Post is as agenda-driven as ever. The leftist commitment of the paper is beyond question. There simply is no reasonable attempt at balanced reporting in the entire piece, even after the edits it was shamed into making.

Second, and far more important, the article exposed the fundamental disagreement between leftists and conservatives when it comes to understanding the role of government.

The U.S. has a long history arguing over the extent government should play in contributing to welfare. Historically, conservatives have long championed a limited government that allows taxpayers to keep more of their money so as to assist their needy family, friends and neighbors as they are able and see fit. Conservatives have correctly argued that massive government income redistribution programs create greater dependency and less individual responsibility. Often these welfare programs, no matter how well intentioned, prove to rob individuals of the needed motivation to work as they lose the initiative for self-reliance, one of the foundational keys to pursuing happiness.

Leftists, on the other hand, dont trust individuals to make wise enough decisions and see the federal governments role as primary in determining what is in the best interests of its citizens. Therefore, regarding problems like poverty, leftists see only a need for greater federal involvement, which of course translates into greater spending as well as loss of freedom. For leftists, statism is the only solution.

Arringtons statement and quotation of Scripture voiced a legitimate concern over the abuse of a system that provides food stamps designed as a safety net, not a free-for-all. The Bible does indeed place a high value on looking out for the needs of others, but it also spends a great amount of text on rebuking laziness, as well as condemning theft and deceit. Due to the propensity of mankind to act selfishly, individuals are often motivated by these base evil desires and take advantage of the generosity of others, be it the government or other individuals.

Essentially, the Washington Post condemns without offering any genuinely honest or thoughtful commentary over the realistic concerns voiced by conservatives regarding both the appropriate role of government and the attendant budgetary concerns. Nor does the Post even attempt to accurately portray the various Biblical statements.

Its quite evident that the Post is content to misconstrue and grossly misinterpret Christian teaching in an effort to shame all Republicans for not supporting excessive government welfare programs.

At the Washington Post, it is truth, not democracy, that is dying in darkness.

Excerpt from:
Culture, Science & Faith Anatomy of a Smear Piece - Patriot Post

‘Grey’s Anatomy’ Sneak Peek: Maggie Is Paralyzed [Video] – Yahoo – Yahoo TV (blog)

Maggie Pierce is not having a good week.

The Greys Anatomy doctor just lost her mother to breast cancer last episode in a heartbreaking hour. After finally learning abouther moms condition, Maggie (Kelly McCreary) set out in her usual type-A fashion to fix her from risky surgery to a cutting-edge clinical trial treatment. Sadly, nothing could save Maggies mom, and she passed away.

Maggie may not have been able to fix her mother, but she can fix somebody. So in this weeks episode, she takes on a big case even though her fellow doctors arent sure she should.

Perhaps theyre right, because in this exclusive clip, asMaggie and Arizona (Jessica Capshaw) perform surgery, the patient starts to lose vitals.

Dr. Pierce, whats your move here? Arizona asks. Maggie remains still and silent. Is she freezing up? Is she unable to continue out of grief?

Greys Anatomy airs Thursdays at 8 p.m. on ABC. Watch recent episodes of Greys Anatomy for free on Yahoo View.

Read more from Yahoo TV: Prison Break Recap: Michael Scofield is Resurrected, With a Twist Brockmire Preview: Star Hank Azaria Talks Creating One of TVs Funniest New Characters Spring TV Preview 2017: Get the Scoop on New and Returning Shows

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'Grey's Anatomy' Sneak Peek: Maggie Is Paralyzed [Video] - Yahoo - Yahoo TV (blog)

Street Fighter: the anatomy guide Capcom uses for its games – Den of Geek UK

Have you ever wondered why it is that Street Fighter characters all seem to be based on the same basic build? You haven't? Oh. Well...off you go.

For the rest of you, it turns out that the classic Street Fighter look has nothing to do with a lack of creativity on the part of the designers, but rather a basic anatomy template that Capcom has been using for years.

As part of a Gamasutra article, Toshiyuki Kamei spoke about a guide Capcom uses which outlines the basic anatomy structure they adhere to for some of their characters. The guide was partially created by former Capcom artist Akira Yasuda and goes into pretty in-depth detail regarding the basic design and movement of certain Capcom charactermodels.

The guide seems to largely focus on Capcom fighting games - particularly Street Fighter - and Kamei admits that it hasn't really been formally updated over the years. That means that most of the technical design references it mentions actually relate to the sprite era of gaming graphics.

Even so, the guide is treated as the foundation of fighting game character design to this day. It's not hard to see why. The sketches within the book detail everything from shoulder muscle movement to the proper design of abdominals (Spoilers: the proper design is "ripped") and giveyou a good idea of what kind of detail character artists have to think in if they want to create semi-believable characters.

Actually, the outdated nature of the guide makes many of the sketches featured within it that much more impressive. At a time when technology barely allowed for anything more advanced than a pixel, artists were already imagining details and designs that wouldn't even be possible until decades later. The fact that any of this information is still relevant - much less valid - is pretty shocking.

The drawings are pretty stunning, and well worth looking over carefully if you've an interest in game design or comic book art: we love that Yasuda's even gone to the effort of showing cross-sections of the character's limbs.

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Street Fighter: the anatomy guide Capcom uses for its games - Den of Geek UK