DEAR MAYO CLINIC: Why does it seem that suicide tends to run in families? Does it have anything to do with genetics?

The association between genetics and suicide is complicated. Research has shown that there is a genetic component to suicide. But it is only one of many factors that may raise an individual's risk. And even if someone is at high risk for suicide, that doesn't predict whether or not an individual will actually act on suicidal thoughts.

Genetic research, including studies involving twins, has revealed that many psychiatric conditions, including having suicidal tendencies, are influenced by genetics. While studies demonstrate that specific genes, such as one called the BDNF Met allele, can increase risk for suicide, it's more likely that a range of genes affect connections and pathways within the brain, and impact suicide risk.

Complicating matters further, a process called epigenetics also comes into play when considering the effect of genes on suicide. This process controls when certain genes are turned on or off as a person grows and develops, and it can be influenced by what happens in a person's environment.

For example, if someone goes through a difficult event as a child, that experience could have an impact on how or when a gene is activated within that person's brain. Researchers speculate that negative experiences influencing epigenetics in a person who has a family history of suicide could further compound that person's suicide risk.

In addition, it is known that 90 percent of people who die by suicide have a psychiatric illness at the time of death. Mood disorders, psychotic disorders, certain personality disorders and substance use disorders can increase suicide risk substantially. Each of those disorders has a genetic component, too.

It's important to understand, however, that an increased risk of suicide does not predict who will commit suicide. For some people even those whose genetics may seem to predispose them to a higher suicide risk the thought of suicide doesn't enter their minds. For others, suicide quickly may become a focus of their thoughts.

For those whose thoughts do turn to suicide, the way they arrive at suicidal thoughts may be a well-imprinted and familiar pathway. Psychotherapeutic treatment can help examine the process they go through to get to that point and find ways to interrupt the process.

Genetics, family history and environment all matter when it comes to the risk of suicide. But knowing risk factors is not a substitute for a thorough assessment of an individual's situation and the process he or she takes to arrive at suicidal thoughts.

If you or a loved one is concerned about your risk for suicide, or if you've had suicidal thoughts, talk to a mental health professional. To help you find ways to break the cycle that leads to suicidal thoughts, he or she can work with you to treat any psychiatric illness that may be present and help you understand the process you're going through when you turn to the possibility of suicide.

If you are in a suicide crisis or emotional distress, the National Suicide Prevention Lifeline provides free, confidential emotional support 24/7 at 1-800-273-8255 (toll-free). Brian Palmer, M.D., Psychiatry and Psychology, Mayo Clinic, Rochester.

Mayo Clinic Q & A is an educational resource and doesnt replace regular medical care. Email a question to MayoClinicQ&A@mayo.edu. For more information, visit http://www.mayoclinic.org.

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Association between genetics and suicide is complicated - Post-Bulletin

Recently, Vitaliy Husar received results from a DNA screening that changed his life. It wasn't a gene that suggested a high likelihood of cancer or a shocking revelation about his family tree. It was his diet. It was all wrong.

Illustration: Angelica Alzona/Gizmodo

That was, at least, according to DNA Lifestyle Coach, a startup that offers consumers advice on diet, exercise and other aspects of daily life based on genetics alone. Husar, a 38-year-old telecom salesman, had spent most of his life eating the sort of Eastern European fare typical of his native Ukraine: Lots of meat, potatoes, salt and saturated fats. DNA Lifestyle Coach suggested his body might appreciate a more Mediterranean diet instead.

"They show you which genes are linked to what traits, and link you to the research," Husar told Gizmodo. "There is science behind it."

DNA Lifestyle Coach isn't the only company hoping to turn our genetics into a lifestyle product. In the past decade, DNA sequencing has gotten really, really cheap, positioning genetics to become the next big consumer health craze. The sales pitch a roadmap for life encoded in your very own DNA can be hard to resist. But scientists are sceptical that we've decrypted enough about the human genome to turn strings of As, Ts, Cs and Gs into useful personalised lifestyle advice.

Indeed, that lifestyle advice has a tendency to sound more like it was divined from a health-conscious oracle than from actual science. Take, for instance, DNA Lifestyle Coach's recommendation that one client "drink 750ml of cloudy apple juice everyday to lose body fat".

"Millions of people have had genotyping done, but few people have had their whole genome sequenced," Eric Topol, a geneticist at Scripps in San Diego, told Gizmodo. Most consumer DNA testing companies, like 23andMe, offer genotyping, which examines small snippets of DNA for well-studied variations. Genome sequencing, on the other hand, decodes a person's entire genetic makeup. In many cases, there just isn't enough science concerning the genes in question to accurately predict, say, whether you should steer clear of carbs.

"We need billions of people to get their genome sequenced to be able to give people information like what kind of diet to follow," Topol said.

Husar stumbled upon the Kickstarter page for DNA Lifestyle Coach after getting his DNA tested via 23andMe a few years earlier. He wondered whether there was more information to be gleaned from his results. So six months ago, he downloaded his 23andMe data and uploaded it to DNA Lifestyle Coach. Each test costs between $US60 ($78) and $US70 ($91).

"I'm always looking for some ways to learn about my health, myself, my body," said Husar, who contributed to the company's Kickstarter back in 2015.

The advice he got back was incredibly specific. According to DNA Lifestyle Coach, he needed to start taking supplements of vitamins B12, D and E. He needed more iodine in his diet, and a lot less sodium. DNA Lifestyle Coach recommended that 55 per cent of his fat consumption come from monounsaturated fats like olive oil, rather than the sunflower oil popular in Ukraine. Oh, and he needed to change his workout to focus more on endurance and less on speed and power.

He switched up his workout and his diet, and added vitamin supplements to his daily routine. The results, he found, were hard to dispute: He lost 3kg, and for the first time in memory didn't spend Kiev's long harsh winter stuck with a bad case of the winter blues.

Image: A sample of a DNA Lifestyle Coach customer's fitness recommendations provided by a customer.

For now, DNA Lifestyle Coach's "interpretation engine" only offers consumers advice on diet and exercise, but in the coming months it plans to roll out genetics-based guidance on skin care, dental care and stress management. The company wants to tell you what SPF of sunscreen to use to decrease your risk of cancer, and which beauty products to use to delay the visible effects of ageing. Its founders told Gizmodo that eventually they envision being able to offer their customers recipes for specific meals to whip up for dinner, optimised for their genetic makeup.

DNA Lifestyle Coach joins a growing list of technology companies attempting to spin DNA testing results into a must-have product. The DNA sequencing company Helix plans to launch an "app store for genetics" later this year. One of its partners is Vinome, a wine club that for $US149 ($194) a quarter sends you wine selected based on your DNA. Orig3n offers genetics-based assessments of fitness, mental health, skin, nutrition and even obviously unscientific which superpower you are most likely to have. The CEO of the health-focused Veritas Genetics told Gizmodo that the company hopes to create a "Netflix for genetics", where consumers pay for a subscription to receive updated information on their genome for the rest of their life.

"It's not going to happen overnight, but we believe that DNA will become an integrated part of everyday life," Helix co-founder Justin Kao told Gizmodo. "The same way people use data to determine which movie to see or which restaurant to eat at, people will one day use their own DNA data to help guide everyday experiences."

Few would debate that our capability to decipher information from our genetic code is getting a lot more sophisticated. Just a decade ago, a bargain-basement deal on whole genome sequencing would run you $US300,000 ($391,491). Recently, DNA sequencing company Illumina announced plans do it for just $US100 ($130) within the next decade. Every day, researchers discover new links between our health, our environment and our genetics.

But much of this research is still preliminary, and many of the studies are small. DNA Lifestyle Coach's advice to drink 750ml of cloudy apple juice for fat loss, for instance, stemmed from a study of just 68 non-smoking men. Those results, while promising, still require much larger studies to confirm. Suggesting that the same regiment might work for consumers is a little like reading the leaves at the bottom of a tea cup extracting meaning from patterns that aren't necessarily there.

Not to mention that the information our genes offer up is probabilistic, not deterministic. You may have run into this if you've done an ancestry DNA test and received results indicating that your parents are only "very likely" your parents. More often than not, many genes contribute to a specific trait like taste and how those genes all interact is a complex and poorly understood web. To complicate matters further, the expression of genes is often impacted by our behaviour and the environment. If you have a gene that raises the risk for skin cancer, but live in overcast Seattle and don't ever go outside, your chances of getting cancer are probably slimmer than someone who lives in Sydney and spends every day in the sun without slapping on some sunblock.

DNA Lifestyle Coach, though, wants to offer its customers simple, actionable advice, and so omits all this confusing grey area from its results. Instead, the recommendations are clear and specific, from how much Vitamin A to take to how many cups of coffee a day are most beneficial. It's a bit reminiscent of a long-term weather forecast spitting out predictions for sunshine or rain 30 days in advance yes, such predictions can be made, but most meteorologists will tell you they're borderline useless.

Image: A sample of a DNA Lifestyle Coach customer's diet recommendations provided by a customer.

"We use a series of algorithms which rank studies by reliability of results," the company website explains. "Studies are then analysed for their relation to real-world dietary and nutritional needs, and the user is given straightforward recommendations."

Pressed on the questionable nature of that apple juice study, DNA Lifestyle Coach's founders responded that the "data is not as strong" as the the other studies it pulls from. "But it is a harmless recommendation," the company said.

When asked whether it was possible that DNA Lifestyle Coach's claims might have any validity, Topol laughed.

One day, he said, it's likely we'll have some genomic insight into what types of diets are better suited for certain people. But, he added, it's unlikely that we will ever accurately predict the sort of granular details DNA Lifestyle Coach hopes to, like exactly what SPF of sunscreen you should be using on your skin.

"There are limits," he said.

Image: A sample of a DNA Lifestyle Coach customer's diet recommendations provided by a customer.

DNA Lifestyle Coach was founded by a chemist and a business consultant who met over an interest in the biohacker scene, a subculture focused on ideas like DIY life extension. The company that runs DNA Lifestyle Coach, Titanovo, actually started as a blog. The name is meant to invoke superhumans. "It's like the rise of the titans," said Corey McCarren, the business side of the duo, when Gizmodo met with him at a health "moonshots" conference last month.

Their first foray into genetics was a home telomere length test, which launched in 2015 with help of $US10,000 ($13,050) raised on Indiegogo. Telomeres are little bits of DNA at the end of chromosomes. Each time a cell divides, its telomeres get shorter, and so they provide some insight into our biological age. Titanovo wanted to develop an easy test to tell consumers how long or short their telomeres were. The company initially pitched the test as a way to measure both longevity and health, but eventually was forced to clarify for customers that it is not at present possible to discern biological age from telomeres alone, after receiving emails from customers panicked about their own short telomeres.

Instead, they suggest, the $US150 ($196) telomere testing kit is a way to discern information about health. One finding from their data: Vegetarians and vegans who use the service have, on average, longer telomeres. The company recommends going veg if you find your telomeres are in need of a boost. Even this, however, seems like a stretch: Data on telomere length, like genomics, is not quite ready for public consumption. For every paper that finds a potential cause of telomere shorting, there's one that finds the opposite effect.

Undaunted by the rocky rollout of its telomere testing kit, Titanovo is now pressing forward into genomics. The Kickstarter campaign for DNA Lifestyle Coach wound up raising more than $US30,000 ($39,149). The company says it now has more than 1000 customers who either pay $US215 ($281) for the full DNA testing kit along with one panel, or the $US60 ($78) to $US70 ($91) to run panels with data from services like 23andMe.

While it might seem harmless to take part in a little science-based superstition and find out whether you're more Batman or Superman, such indulgence can have serious side effects. For years, we've been sold on DNA as the answer to almost everything. Decode the human genome, and decode the "mysteries of the human spirit". This gives companies like DNA Lifestyle Coach dangerous authority. If your DNA testing results say you're prone to obesity, why spend time exercising and eating right when your health seems beyond your control?

Joshua Knowles, a Stanford Cardiologist who studies applied genetics, told Gizmodo that he recently had a patient who was unwilling to try a certain class of drug based on their genotyping, even though they had a high risk of heart disease that might be drastically reduced by use of those medications.

"We're doing a poor job of educating patients on risk-benefit analysis," Knowles said. "In some cases, when it comes to genetics, we're placing a lot of weight on some things that have very small overall effects."

In 2008, an European Journal of Human Geneticsarticle argued for better regulatory control of direct-to-consumer genetic testing, asking whether in the end, tests ran the risk of being little better than horoscopes that told people information they were already predisposed to believe.

It was these kinds of concerns that moved the US Food and Drug Administration to crack down on 23andMe in 2013, ordering the company to cease providing analyses of people's risk factors for disease until the tests' accuracy could be validated. The company now provides assessments on a small fraction of 254 diseases and conditions it once scanned for it still processes the same information, but is restricted in what it can tell consumers. Where it once reported "health risks" alongside specific tips and guidance on how to reduce them, it now reports on your "carrier status", framing the results in terms of whether you might pass down a specific genetic variant to your offspring rather that whether you might develop the condition yourself.

Companies like DNA Lifestyle Coach have moved in to offer the sort of tips 23andMe no longer can.

"We have much too many companies doing nutrigenomics and other unproven things like that," said Topol. "That can give consumer genomics a really bad name. That's unfortunate."

Kao, of Helix, said that educating consumers on what these results really mean alongside actionable information will be the industry's greatest challenge and what distinguishes it from just another pseudoscientific health fad.

"It's typically been very hard to interpret DNA information," Kao said. "DNA is most valuable with context, rather than as the only piece of the puzzle."

The industry, he argues, is young, but will get more accurate the more consumers use DNA-testing products. "Just as Netflix improves the more you rate shows you watch, so would many DNA-based products," he said.

Husar told Gizmodo that he got blood work done to confirm what he could about his DNA Lifestyle Coach results. The tests indeed confirmed that he was low on vitamins B12, D and E, as DNA Lifestyle Coach had suggested. Of course, Hussar still can't be sure his genes are responsible. It could be that he's simply not eating enough meat or cheese. Still, the blood work was enough to convince Husar that DNA Lifestyle Coach's analysis was worth taking seriously. And, for the most part, the results felt right it made sense that a boost of vitamin B12 might counteract the emotional toll of winter, and that cutting out potatoes and saturated fats might be beneficial.

The tests's fitness results though, he did find a tad shocking.

"I was really surprised to learn that I'm not fast or powerful, but I have a high endurance," he said. "I can do Iron Man. This is what my genetics say. I'm trying to change my workout to see if that's true."

Husar may never be sure whether the advice divined from his genetics was really helpful. He can only hope it doesn't hurt.

Originally published on Gizmodo Australia.

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The Next Pseudoscience Health Craze Is All About Genetics - Lifehacker Australia

As analysts monitor volatile markets in recent weeks they have updated their price targets on shares of Seattle Genetics, Inc. (NASDAQ:SGEN). Based on the latest notes released to investors, 2 analysts have issued a rating of buy, 4 analysts outperform, 10 analysts hold, 1 analysts underperform and 0 analysts sell.

Latest broker research notes issued:

03/15/2017 Oppenheimer began new coverage on Seattle Genetics, Inc. giving the company a perform rating.

02/13/2017 Seattle Genetics, Inc. had its neutral rating reiterated by analysts at Credit Suisse. They now have a USD 66 price target on the stock.

02/10/2017 Seattle Genetics, Inc. was downgraded to underperform by analysts at Bank of America Merrill Lynch.

12/29/2016 Seattle Genetics, Inc. had its neutral rating reiterated by analysts at Cantor Fitzgerald. They now have a USD 43 price target on the stock.

12/27/2016 Seattle Genetics, Inc. had its buy rating reiterated by analysts at Needham & Company. They now have a USD 72 price target on the stock.

11/29/2016 Seattle Genetics, Inc. was downgraded to equal-weight by analysts at Barclays. They now have a USD 70 price target on the stock.

10/21/2016 Seattle Genetics, Inc. had its outperform rating reiterated by analysts at Leerink Swann. They now have a USD 62 price target on the stock.

10/10/2016 Seattle Genetics, Inc. had its outperform rating reiterated by analysts at RBC Capital. They now have a USD 62 price target on the stock.

09/15/2016 Seattle Genetics, Inc. was upgraded to neutral by analysts at Goldman Sachs. They now have a USD 47 price target on the stock.

09/07/2016 Morgan Stanley began new coverage on Seattle Genetics, Inc. giving the company a overweight rating. They now have a USD 60 price target on the stock.

07/27/2016 Seattle Genetics, Inc. had its neutral rating reiterated by analysts at SunTrust. They now have a USD 38 price target on the stock.

02/10/2016 Seattle Genetics, Inc. had its neutral rating reiterated by analysts at JP Morgan. They now have a USD 43 price target on the stock.

02/10/2016 Seattle Genetics, Inc. had its neutral rating reiterated by analysts at Piper Jaffray. They now have a USD 33 price target on the stock.

08/25/2015 Seattle Genetics, Inc. had its buy rating reiterated by analysts at William Blair.

08/03/2015 Seattle Genetics, Inc. had its market perform rating reiterated by analysts at Cowen. They now have a USD 40.5 price target on the stock.

The share price of Seattle Genetics, Inc. (NASDAQ:SGEN) was down -0.03% during the last trading session, with a day high of 67.30. 1028309 shares were traded on Seattle Genetics, Inc.s last session.

The stocks 50 day moving average is 64.32 and its 200 day moving average is 59.50. The stocks market capitalization is 9.51B. Seattle Genetics, Inc. has a 52-week low of 32.40 and a 52-week high of 75.36.

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Seattle Genetics, Inc. (NASDAQ:SGEN) Valuation According To Analysts - UK Market News

Husband and wife team, Brian James and Lorna Sixsmith, have a 130-cow spring-calving Holstein Friesian herd.

Based in Garrendenny, Crettyard, Co. Carlow, the couples herd increased from 115 cows in 2016. And in recent times, their milking platform has moved from about 49ha to 69ha.

The pair have farmed since 2002, after taking over from Lornas father, and farming has been a second career for them both.

The herd has an EBI of 149 and is currently ranked 28th on the latest EBI herd ranking (February 2017), with a fertility sub-index of 81, a production sub-index of 36 and +0.08% protein.

The herd is delivering 480kg of milk solids, while maintaining a 365-day calving interval and a 6% empty rate.

The cows normally get out to grass by day in February and are out full-time by March. The herd is housed by night in late October and ishoused full-time during the first week of December.

However, the farm is fairly heavy in places and getting out to grass has been delayed for the last two seasons. But the cows have been able to graze more in the back-end of both years.

This delayed access to spring-grass led to more meal being fed last year than would normally be the target of about 800kg/cow.

That said, Brian does like a happy cow and a contented cow and when push comes to shove he wouldnt begrudge them extra meal feeding.

The couple arrived back toGarrendenny 15years ago to a largely British Friesian type herd and used some Rotbunt genetics initially.

Solids production then became the major focus and they selected high-protein Holstein Friesian sires. Since then milks solids production has been steadily rising.

Milk protein has climbed from 3.3% to 3.7%, while fat improved from 3.7% to 4.3%.

Brian says this means solids sold have gone from 300kg to nearly 500kg (milk solids). The national average is still 372kg.

The herds fertility is top class with a 365-day calving interval and an average of 285 days in milk, but a few April and May calvers drag that latter figure down. When these cows are excluded, the average days in milk rises to 294.

Virtually all cows were served last year within six weeks and there was a 5.5% involuntary culling rate.

In 2016, the herd delivered 480kg of milk solids to the creamery and that was after a late turnout and a reduced grazing season, as highlighted above.

The couples ideal cow weighs 500kg, produces 500kg of milk solids and calves every 365 days.

Brian said his ideal cow is one that calves down every year, gives a reasonable volume and doesnt give me any hassle with mastitis or whatever.

The herd also uses the AI Service to reduce labour and for convenience. When asked about this Brian simply says: We have enough to do.

When he began using Progressive Genetics AI Service, he didnt like moving away from twice-a-day AI. Now he says its the best thing I ever did.

It works out well; Im happy with it, he said, and it leads to less stress on the cows and a conception rate to the first service of over 60%.

Bulls that feature amongst the milking cows are by GMZ, CFF, VML, BHZ, LLK, LHZ, HMY, TSK, PBM, AAC and ABO, amongst others.

The heifers coming into the parlour this year are predominantly sired by YGB, PBM, PSZ and PKR.

Some of the sires Brian used last year were: FR2007, FR2030, FR2032, FR2040, FR2041, FR2275, KAZ and LWR. The focus is very much on protein, fertility and a hardy, compact cow.

The herd genetic level is +0.08% protein, producing 3.70% protein.

An average herd could achieve this level using bulls +0.15% protein in their EBI, which is easily achievable from todays top bulls.

LLK daughter Garrendenny Llk Skye 1794 recently calved for the fourth time as she had an LWR bull calf on the 16th February.

The latest calving gives the cow a 363 day calving interval and over her three lactations to date she has produced 1,576kg of milk solids.

In her last lactation, she averaged 4.19% fat and 3.75% protein or a milk solids production of 643kg.

This cow has never had a high SCC, with her three lactations to date averaging 45,000, plus her genomically tested EBI is 156.

The couple uses the DIY Milk Recording Service, which is found to be reliable and convenient, but is primarily a very useful tool for improving milk quality and therefore increasing milk price.

The herds SCC ranged from 86,000 to 181,000 in 2016.

Milk recording helped achieve this, as after every recording problem cows are highlighted in the Mastitis Incidence Problem Cow Report and the Cell-check Farm Summary helps identify areas the herd can improve on.

Milk Recording regularly provides information on which Brian ranks cows and makes breeding decisions. It enables him to highlight top cows, identify weak areas with other cows, allowing the couple to cull unprofitable cows with persistently high SCC counts.

For more information on the services provided by Progressive GeneticsClick Here

Sponsored by Progressive Genetics

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Delivering nearly 500kg of milk solids with Holstein Friesian genetics - Agriland

Your genetic profile can reveal whether you have a disease or a predisposition to problems like cancer. So there is concern over a bill that would let companies request genetic testing, and effectively charge employees more for health insurance if they refuse.

The bill aims to clarify rules for workplace wellness programs. Employers would be able to offer discounts of up to 30 percent to those who participate. For the average family of four, that could be a difference of more than $1,500 a year.

But critics of this new bill say theres no telling how companies could use that information in the future. To them, its a choice between losing privacy or losing what could be thousands of dollars in savings.

Joselin Linder told correspondent Tony Dokoupil that, most of the time, she doesnt mind discussing the genetic illness that runs through her family attacking a vein in the liver.

So my grandmother passed it to two sons and watched two sons die of this gene, she said.

But she wouldnt want a boss to know the details of her family tree.

Dokoupila sked, How do you think you would feel if an employer said, We want to see your genetic test or were going to charge you 30% more for health insurance?

I think it would feel like a penalty, she replied.

What Linder calls a penalty, North Carolina Congresswoman Virginia Foxx sees as motivation. She introduced a bill that would allow companies to offer insurance premium discounts to workers who undergo genetic testing as part of a workplace wellness program.

If they dont participate in the wellness program, their premium is going to be the same as everyone else, Foxx said.

With the exception of the people who participate in the program, said Dokoupil.

Well, its an incentive to participate in the program, Foxx replied.

Nancy Cox, president of the American Society of Human Genetics, countered, Its hard to imagine a good reason for wanting this information.

In a letter to Congress, her organization (and dozens of others) said the bill would impose draconian penalties on employees.

Federal law bans companies from using genetic information to hire, fire or discriminate. But critics say a simple blood or saliva test could eventually reveal so much about a persons health and abilities that the urge to peek might be irresistible.

There are possibilities for misusing genetic information that make it very important for this information to be private, Cox said.

When asked about the opposition to her bill, Rep. Foxx said, We are totally surprised.

She points to the benefits of companies engaging in workers health: It will save people money, and it also will help them achieve a better quality of life.

Most large companies offers wellness programs, which are supposed to encourage healthy living, prevent disease, and lower health costs.

But Joselin Linder doesnt think shed ever join one if it meant handing over her genetic information. I think all of us deserve our privacy, Linder said, and I think all of us deserve healthcare.

The Kaiser Family Foundation reports theres little evidence so far that wellness programs actually improve workers health.

Foxxs bill passed a House committee this month, and she is is optimistic about its chances of becoming law.

But with opposition mounting, it could be a tough sell in the Senate.

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Should companies be allowed to demand your genetic test results? - CBS News