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SFI Approves Funding in Principle for New Trinity Immunology Research Centre – The University Times

Risn PowerNews Editor

Sinad Baker for The University Times

Trinitys new research centre has had their funding application to Science Foundation Ireland (SFI) approved. However, the new centre will have to wait to wait for the government to increase the science and research budget to receive the funding.

It was announced today that the funding application for the INNATE Inflammation and Immunology Research Centre, along with seven other new research facilities across the country, was approved by the state funding group. However only four will receive a collective 72 million now, over the next four years, as SFI seeks a bigger budget from the government to support the other four, including INNATE, over the next six years.

These four facilities have over 100 partnerships with companies that have committed 60 million in funding to the centres. Speaking about the decision in a press statement, Prof Mark Ferguson, Director General of SFI and Chief Scientific Advisor to the Government of Ireland said: We need to be ambitious and invest in areas of real potential to ensure our future economic competitiveness.

Over the coming months we will be working to seek additional funding to support these four SFI Research Centres that have been approved in principle. I am greatly encouraged by the high quality of research and the significant level of industry and international engagement in the proposals, Ferguson continued.

The funding from SFI will fund the setup of the new centre, which will include the refurbishment of a space in Trinity Biomedical Sciences Institute (TBSI), where the centre will be based.

INNATE will set out to research the immune system and inflammation. Inflammation is the reaction our body has in fighting infection, that can also, when misdirected, lead to diseases such as arthritis.

Trinitys other research institutes funded by SFI include the Centre for Future Networks and Communications research (CONNECT), the Centre for Advanced Materials and Bio-Engineering Research (AMBER) and ADAPT, which specialises in digital technology. They collaborate with industry and other researchers across the world.

At a meeting of Trinitys Finance Committee in December, the committee committed to aiding the refurbishment of the space in TBSI as Trinitys contribution to the new facility. However, any additional rental costs for extra space thats needed will come from INNATE.

At the meeting, the committee also noted that INNATE should seek financial support from the Faculty of Health Sciences, should the application be successful. They also said that the Faculty of Health Sciences should make a contribution to the refurbishment of the space in TBSI.

SFI gave Trinity 2.4 million in funding, in February, towards the development of the Colleges infrastructure, and numerous principal investigators. In 2015/16 SFI made up 46 per cent of Trinitys total research income, contributing 44.2 million that year. This was nearly 10 million more than the year previous.

The four new SFI centres announced today, and to be formally launched in September 2017, will specialise in smart and innovative manufacturing, alternatives to fossil fuels and diagnosis and treatment of chronic and rare neurological diseases. Two of the new centres will be in University College Dublin (UCD) and then one in the University of Limerick and the final centre will be in Royal College of Surgeons Ireland (RCSI).

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SFI Approves Funding in Principle for New Trinity Immunology Research Centre - The University Times

Human Behavior and Cognition Expert, Tony J. Selimi, Featured on NBC – MENAFN.COM

(MENAFN Editorial)

Human Behavior and Cognition Expert, Tony J. Selimi, Featured on NBC

Tony J. Selimi, Human Behavior and Cognition Expert, Speaker, Educator and Internationally Published Author, was recently seen on ABC, NBC, CBS and FOX network affiliates around the country as a guest on The Brian Tracy Show

London, England May 2, 2017 Tony J. Selimi, Human Behavior and Cognition Expert, was recently a featured guest on The Brian Tracy Show. The show was hosted by Best-Selling Author and one of the country's leading business minds, Brain Tracy, and features business leaders and experts from around the world. Tony J. Selimi was one of Brian Tracy's recent guests, discussing his five step method to maximize human awareness and awaken people's innate healing faculties, the TJS Evolutionary Method.

Selimi's expertise and specialization in helping people realize their full potential led to an invite to the set of The Brian Tracy Show to tell the revolutionary story on how he went from living homeless on the streets of London to becoming a thought leader. His work has changed the lives of his clients by helping them align their highest values to their daily lives, build iconic ethical businesses, co-loving relationships, achieve work-life balance, and find inner peace and attain ultimate health. His feature has been seen by viewers across the country, and has undoubtedly inspired many.

The Brian Tracy Show, filmed in San Diego, California, is produced by Emmy Award-winning Director and Producer, Nick Nanton, Esq. and Emmy Award winning Producer, JW Dicks, Esq., Co-Founders of America's PremierExperts and The Dicks and Nanton Celebrity Branding Agency. The episode featuring Selimi recently aired on NBC, CBS, ABC and FOX affiliates across the country.

Watch Selimi's appearance on The Brian Tracy Show here: https://www.youtube.com/watch?v=TyeYlGrASdw

About Tony J. Selimi:

Tony Jeton Selimi went from being a teenage victim of war feeling hopeless, impoverished, and abandoned on the streets of London, to graduating with honors from one of London's most prestigious engineering universities UCL. He build a very successful IT career before following his hearts calling to follow the entrepreneurial path that led him to become No.1 Amazon bestselling and award-winning author, key note speaker, co-creator of Living My Illusion Documentary Series and the founder of TJS Cognition, a service educational institution dedicated to unravelling, advancing, and elevating human potential.

He specializes in assisting businesses owners from all market sectors and people from all professions find solutions to their personal and business problems, accelerate their learning, and achieve excellence in all of the eight key areas of life: Spiritual, Mental, Emotional, Physical, Business, Money, Relationship and Love.

Like a transparent mirror, Tony is known for his ability to see through people' problems, unconscious behaviors, thought patterns, skewed perceptions, and dis-empowering beliefs that prevent them from creating and delivering astronomical visions and living the lifestyle they dream about. He helps them break free from shame, guilt, expectations, control, fears, trauma, addictions and other mental, emotional, physical, and spiritual blockages by upgrading their 'cognitive operating system and teaching them how to tap into the infinite wisdom of their interstellar existence.

As a business consultant he globally provides answers to questions and practical solutions to life's challenges in talks, workshops, one to one coaching, mastermind groups, retreats, articles, radio and TV interviews as well as through his books and online downloads of Audio Books and the TJS Evolutionary Meditation Solutions.

His clients are entrepreneurs, leaders, and people from all walks of life who seek his help to manifest their highest vision, to be more healthy, wealthy, wise, spiritual and influential. They range from Coaches, #Sports Personalities, Musicians, Celebrities, MPs, Dr's, Scientists, to CEO's and Managers of FTSE 100 companies such as Microsoft, SAP, Bank of America, E & Y, Gayacards, Vandercom and Deutsche Bank.

Tony appeared in various national magazines including Soul and Spirit, Global Women, Science to Sage, Hitched, Migrant Women, Accelerate Your Business, Changing Careers Magazine, Consciousness Magazine, Your Wellness, Time Out, Pink Paper, Gay Star News, Key Person Influence, and Soul Mate Relationship World Summit.

Some of his recent TV appearance include Digging Deep Show for SKY TV, Top Channel, Klan Kosova, AlsatM, Jeta KohaVision, RTM, MTV2, Kanal 21, and Shenja.

Tony's unique wisdom is sought regularly by various radio broadcasters to inspire their listeners including Hay House Radio, Voice of America, Radio Macedonia, Radio Kosova, Beyond 50, Knowledge for Men, Love and Freedom, Empty Closet, Donna Sebo Show, News for the Soul, Channel Radio, Untangled FM, Self-Discovery, and Spirit Radio.

He loves travelling, consulting, researching, teaching, speaking, and coaching clients globally. Tony loves using his creative flair and in partnership with the owners of Vandercom, a leading telecommunication and IT service Provider Company, he is co-creating inspiring films and documentaries that share his clients' real life breakthrough stories that are emotionally engaging, mind illuminating, and heart awakening to move people into action.

He is known for creating amazing transformation and leaving his clients feeling revitalized, energized, and with a sense of inner peace.

If you would like to learn more about Tony J. Selimi and his services, connect with him at: http://TonySelimi.com

###

Contact:

Christine Enberg

Dicks and Nanton Celebrity Branding Agency

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Human Behavior and Cognition Expert, Tony J. Selimi, Featured on NBC - MENAFN.COM

Here’s Why Myriad Genetics Rose as Much as 16% This Morning – Motley Fool

What happened

Shares of genetic-testing pioneer Myriad Genetics (NASDAQ:MYGN) received a much-needed boost today, rising as much as 16%, after the company announced fiscal third-quarter 2017 financial results. The stock has witnessed a 42% decline in the last year, although it is now up roughly 28% year to date, as investors see signs of life for the company's most important revenue machine and are holding out hope for a pipeline of promising growth products.

The strong performance in the most recent quarter prompted management to raise its full-year fiscal 2017 financial guidance for revenue and narrow the range for earnings per share. As of 12:45 p.m. EDT, the stock had settled to a 15.5% gain.

Image source: Getty Images.

There were reasons for optimism and pessimism in the financial update. Consider how the most important products fared compared to last year's fiscal third quarter:

Metric

Fiscal Q3 2017

Fiscal Q3 2016

% Change

Hereditary-diagnostic-testing revenue

$140.8 million

$156.3 million

(10%)

GeneSight testing revenue

$23.9 million

N/A

N/A

Vectra DA testing revenue

$11.2 million

$12.3 million

(9%)

Prolaris testing revenue

$3.4 million

$5.2 million

(35%)

EndoPredict testing revenue

$2.3 million

$1.1 million

109%

Other revenue

$3.6 million

$2.5 million

44%

Data source: Myriad Genetics.

A 10% year-over-year drop in revenue from hereditary diagnostic testing may not seem like much reason to celebrate, but it marks the second consecutive sequential gain for Myriad Genetics after many quarters of decline. It's a silver lining investors aren't willing to overlook.

Of course, the array of promising growth products is turning in more mixed results. Products excluding GeneSight combined for a year-over-year drop in revenue of $1.7 million. In fact, if not for GeneSight, Myriad Genetics' total revenue would have declined. It's a major reason for the updated revenue guidance -- and investors should be happy to have GeneSight growing into a significant contributor to the overall business and performing well against offerings from competitors.

Metric

Fiscal Q3 2017

Fiscal Q3 2016

% Change

Total revenue

$196.9 million

$190.5 million

3%

Operating expenses

$139.7 million

$107.7 million

30%

Net income

$4.2 million

$34.5 million

(88%)

Data source: Myriad Genetics.

Efforts to rapidly scale new products and services have resulted in a large increase in operating expenses in recent quarters, eating away at net income. Last quarter was no different, but the increase in operating expenses is a necessary evil for investors looking for the company to turn the page long-term.

The company now expects full-year fiscal 2017 revenue to fall between $763 million and $765 million, compared to $754 million in fiscal 2016. Meanwhile, diluted earnings per share are expected to fall between $0.23 and $0.25, compared to $1.71 in fiscal 2016.

Investors are aware that Myriad Genetics is a company in transition, turning away from proprietary testing products (driven by price) and toward cheaper, larger-scale, and more flexible services such as GeneSight (driven by volume) that are in high demand from patients and clinicians. Viewed through that lens, there were no major surprises in the most recent quarter. The company continues to work toward its long-term goals.

Maxx Chatsko has no position in any stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

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Here's Why Myriad Genetics Rose as Much as 16% This Morning - Motley Fool

Harvard Medical School, Sanford Research to Engage Classrooms and Communities Through Genetics – Newswise (press release)

Newswise The Harvard Medical School-based Personal Genetics Education Project (pgEd.org) and the Sanford Program for the Midwest Initiative in Science Exploration (PROMISE) at Sanford Research have teamed to bring the latest developments in genetics into classrooms and communities in Massachusetts and South Dakota.

The Building Awareness, Respect and Confidence through Genetics project, or ARC, is part of pgEds broader initiative to engage high school students and the general public in conversations about the benefits and implications of advances in personal genetics. The Sanford PROMISE will contribute experience and expertise in biomedical science education programming in the northern Plains and extend the project into rural America.

The ARC project, which is supported by a five-year Science Education Partnership Award from the National Institutes of Health, includes creating curriculum and rolling out new and existing curriculum to teachers.

Given where genetic technologies are heading, its now more important than ever to be discussing the possibilities for improving our health and wrestling with the implications of knowing more about our genetic make-up, said Marnie Gelbart, ARC principal investigator and director of programs at pgEd. ARC is a project that sees opportunities for talking about genetics in many settings and relies on the expertise of and collaboration with teachers to bring these conversations into classrooms, schools, and communities.

The curriculum is transdisciplinary and focuses on genetics, identity and diversity through topics such as gender, race, behavior and genome editing. The first module on genome editing was released in February. Additional modules will be released as the grant progresses.

These topics are making their way into workshops for educators, particularly those teaching in middle schools, high schools, colleges and universities.

ARC hopes to empower teachers across all disciplines to stimulate dialogue about personal genetics, said David Pearce, executive vice president of Sanford Research. It has become increasingly important that we all, regardless of status or education background, better understand the benefits and implications the human genome has and will have in their everyday lives.

In the first year of the program, pgEd held a three-day workshop titled Genetics and Social Justice at Harvard Medical School that attracted nearly 50 educators from across the nation. This group included teachers from Brockton High School in Brockton, Mass., (Jonathan Shapiro, science chair, and David Mangus, science) and Harrisburg High School in Harrisburg, S.D. (Lisa Cardillo, science, and Colby Peterson, social studies).

Working with these four lead teachers, pgEd and The Sanford PROMISE are paving the way for future workshops and community events. In April, the pgEd team visited Harrisburg High School for a community experience, and the team will host professional development workshops in Brockton, Mass., in June 2017 and Sioux Falls, S.D., in summer 2018. This summer, two rural high school educators from South Dakota will travel to Brockton with The Sanford PROMISE and work together with the Harrisburg teachers to help bring awareness of genetics to other South Dakota educators.

About Sanford Health Sanford Health is an integrated health system headquartered in the Dakotas. It is one of the largest health systems in the nation with 45 hospitals and nearly 300 clinics in nine states and four countries. Sanford Healths 28,000 employees, including more than 1,300 physicians, make it the largest employer in the Dakotas. Nearly $1 billion in gifts from philanthropist Denny Sanford have allowed for several initiatives, including global children's clinics, genomic medicine and specialized centers researching cures for type 1 diabetes, breast cancer and other diseases. For more information, visit sanfordhealth.org.

About pgEd

The mission of the Personal Genetics Education Project (pgEd.org) is to raise awareness and spark conversation about the benefits as well as the ethical, legal, and social implications of genetic information. We aim to be inclusive of all voices in these discussions,regardless of socioeconomic or educational background, cultural or religious affiliation, and ethnic or personal identity. Founded in 2006, pgEds efforts include providing online curricula, organizing workshops for professionals, holding congressional briefings in Washington, D.C, engaging producers and writers of film and television, convening conferences, supporting an online learning tool (Map-Ed.org), collaborating with museums and libraries, and partnering with communities of faith.

This projectissupported by the National Institutes of Health under grant number R25OD021895. The content is solely the responsibility of the authors anddoes not necessarily represent the official views of the National Institutes of Health.

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Harvard Medical School, Sanford Research to Engage Classrooms and Communities Through Genetics - Newswise (press release)

Ice Age climate change played a bigger role in skunk genetics than … – Phys.Org

May 3, 2017 Western spotted skunk. Credit: Robby Heischman.

Climate plays a key role in determining what animals can live where. And while human-induced climate change has been causing major problems for wildlife as of late, changes in the Earth's climate have impacted evolution for millions of yearsoffering tantalizing clues into how to protect animals facing climate change today. In a new paper in Ecology and Evolution, scientists have delved into the effects of Ice Age climate change upon the evolution of tiny, hand-standing skunks.

"By analyzing western spotted skunk DNA, we learned that Ice Age climate change played a crucial role in their evolution," says lead author Adam Ferguson, Collections Manager of Mammals at The Field Museum in Chicago and affiliate of Texas Tech University. "Over the past million years, changing climates isolated groups of spotted skunks in regions with suitable abiotic conditions, giving rise to genetic sub-divisions that we still see today."

Western spotted skunks are really stinkin' cute at two pounds, they're smaller than the striped Pepe Le Pew variety, their coats are an almost maze-like pattern of black and white swirls, and when they spray, they often do a hand-stand, hind legs and fluffy tail in the air as they unleash smelly chemicals to ward off predators. They're found throughout the Western US and Mexico, in a wide variety of climates they thrive everywhere from Oregon's temperate rainforests to the Sonoran, the hottest desert in Mexico.

There are three genetic sub-groups, called clades, of western spotted skunks. Often, clades develop when a species is split up by geography. If a species is separated by, say, a mountain range, the groups on either side of the mountain may wind up splitting off from each other genetically. However, the division of the skunks into three clades doesn't seem to have been driven solely by geographical barriers populations separated by mountains are more or less genetically identical. Instead, the skunks vary genetically from one historic climate region to another, due to Ice Age climate change.

"Western spotted skunks have been around for a million years, since the Pleistocene Ice Age," explains Ferguson. "During the Ice Age, western North America was mostly covered by glaciers, and there were patches of suitable climates for the skunks separated by patches of unsuitable climates. These regions are called climate refugia. When we analyzed the DNA of spotted skunks living today, we found three groups that correspond to three different climate refugia."

"That means that for spotted skunk evolution, climate change appears to have been a more important factor than geographical barriers," says Ferguson.

In the study, scientists used DNA samples from 97 skunks from a variety of regions and climates in the American Southwest. Upon sequencing the DNA, the scientists were surprised to see that the skunks split into three clades based on pockets of suitable climate present during the Pleistocene.

"Small carnivores like skunks haven't been well-studied when it comes to historical climate change," says Ferguson. "We know how small mammals like rodents respond to changing climates, and we know how bigger carnivores like wolves respond, but this study helps bridge the gap between them."

Ferguson also notes that skunks don't deserve the bad rap they get. "Skunks are a really interesting family of North American carnivores they're well-known, but not well-studied. And studying them comes with a cost they stink, even their tissues stink, and you run the risk of getting sprayed. But they're important to their ecosystems for example, they eat insects and rodents that damage our crops," he says.

Moreover, Ferguson says, the study can illuminate the bigger picture of biodiversity in the face of climate change an issue that grows increasingly relevant as human-driven climate change affects more and more of the world's animals.

"What we know about the past can inform what we expect to see in the future," says Ferguson. "Understanding these genetic subdivisions that happened as a result of changing climatic conditions can help us conserve skunks and other animals in the future."

Before working at The Field Museum, Adam Ferguson was affiliated with Texas Tech University and completed this research there. Ferguson's co-authors are affiliated with Angelo State University, the National Museum of Natural History, the National Zoological Park, the US Fish and Wildlife Service, and the University of New Mexico.

Explore further: Study finds climate, landscape changes may lead to more rabid skunks

Journal reference: Ecology and Evolution

Provided by: Field Museum

While striped skunks already have a nose-worthy reputation for being avoided, new research at the Kansas State University College of Veterinary Medicine finds they carry a serious health threat for humans and animals: rabies.

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Ice Age climate change played a bigger role in skunk genetics than ... - Phys.Org

23andMe and German Pain Specialist Grnenthal Explore the … – PR Newswire (press release)

"This collaboration demonstrates our continued commitment to pain supporting our ambition to deliver four to five new products to patients in diseases with high unmet needs by 2022, as it is Grnenthal's first step into generating Big Data which plays an increasingly important role in drug development and is essential to drive innovation. One perspective in the context of precision medicine is to use human DNA as guidance for which drugs work best in which patients. We aim to use the outcome of the study to identify starting points for the development of innovative, highly effective medicines," emphasizes Gabriel Baertschi, CEO of the Grnenthal Group.

"Pain is a complex disease. As a worldwide leader in pain, we are continuously striving to expand the body of knowledge to offer solutions for those patients who don't have a treatment option today," said Klaus-Dieter Langner, Ph.D., CSO of the Grnenthal Group. "We are very much looking forward to working with our expert collaborators at 23andMe to learn about the causal relationship between genetic patterns and different aspects to pain. Ultimately, our goal is to research and develop innovative, highly effective medicines for patients in need," Langner concludes.

"The goal of this study is to understand genetic factors associated with the experience of pain and response to medications designed to alleviate pain," said Emily Drabant Conley, Ph.D., vice president of business development, 23andMe. "Pain is often a unique experience for each individual, and therefore complex to understand and treat. By leveraging large amounts of genetic and phenotypic data this study may help develop a more personalized approach to pain management."

The new 23andMe and Grnenthal study could shed more light on why individuals experience pain differently by understanding genetic factors associated with pain sensitivity, progression, severity, and response to treatments.

About 23andMe23andMe, Inc. is the leading personal genetics company. Founded in 2006, the mission of the company is to help people access, understand and benefit from the human genome. 23andMe has more than two million customers worldwide, with over 80 percent consented to participate in research. 23andMe, Inc. is located in Mountain View, CA. More information is available at http://www.23andMe.com

About Grnenthal The Grnenthal Group is an entrepreneurial, science-based pharmaceutical company specialized in pain, gout and inflammation. Our ambition is to deliver four to five new products to patients in diseases with high unmet medical need by 2022 and become a 2 billion company. We are a fully integrated research & development company with a long track record of bringing innovative pain treatments and state-of-the-art technologies to patients. By sustainably investing in our R&D above the industrial average, we are strongly committed to innovation.

Grnenthal is an independent, family-owned company headquartered in Aachen, Germany. We are present in 32 countries with affiliates in Europe, Latin America and the US. Our products are sold in more than 155 countries and approx. 5,500 employees are working for the Grnenthal Group worldwide. In 2016, Grnenthal achieved revenues of approx. 1.4 bn. More information: http://www.grunenthal.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/23andme-and-german-pain-specialist-grunenthal-explore-the-genetics-of-pain-to-help-identify-new-treatments-for-patients-300450454.html

SOURCE 23andMe, Inc.

https://www.23andme.com

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23andMe and German Pain Specialist Grnenthal Explore the ... - PR Newswire (press release)

Mitochondria use ‘toolkit’ when free radicals attack – Futurity: Research News

New research shows how mitochondriathe energy generators within cellscan withstand attacks on their DNA from rogue molecules.

The findings could pave the way for new treatments to tackle neurodegenerative diseases and cancer. The research could also have important implications for clinical advances in mitochondrial donationsometimes called a three-parent babyused to correct defects in faulty mitochondria.

The five-year study, published in Science Advances, reveals how the enzyme TDP1already known to have a role in repairing damaged DNA in the cells nucleusis also responsible for repairing damage to mitochondrial DNA (mtDNA).

During the process of energy production and making proteins, a large amount of rogue reactive oxygen species are produced which constantly attack the DNA in the mitochondria. These attacks break their DNA, however the new findings show mitochondria have their very own repair toolkits that are constantly active to maintain their own DNA integrity.

Each mitochondria repair toolkit has unique componentsenzymeswhich can cut, hammer, and seal the breaks. The presence of these enzymes is important for energy production, says lead author Sherif El-Khamisy, professor and chair of molecular medicine at the University of Sheffield.

Defects in repairing DNA breaks in the mitochondria affect vital organs that rely heavily on energy such as the brain. It also has implications on mitochondria replacement therapies recently approved in the UK and known as three parent babies.'

Although much research has focused on how free radicals damage the DNA in the cells nucleus, their effect on mitochondrial DNA is less well understood despite this damage to mtDNA being responsible for many different types of disease such as neurological disorders.

Having healthy mitochondria is also essential for tissue regeneration, making it particularly important for successful organ transplants.

The team further identified a mechanism through which mtDNA can be damaged and then fixed, via a protein called TOP1, which is responsible for untangling coils of mtDNA. When the long strands become tangled, TOP1 breaks and quickly repairs the strands to unravel the knots. If free radicals are also attacking the mitochondrial DNA, then TOP1 proteins can become trapped on the mitochondrial DNA strands, making repair even more difficult.

El-Khamisy believes the findings could pave the way for the development of new therapies for mitochondrial disease that boost their DNA repair capacity, or for cancer treatments which could use TDP1 inhibitors to prevent mtDNA repair selectively in cancer cells.

Cancer relies on cells dividing very quickly. That means they need a lot of energy, so will have really healthy mitochondria, says El-Khamisy.

If we can find a way to selectively damage the mitochondria in the cancer cells, by preventing or slowing its repair mechanism, this could be really promising.

The findings could also be important for new clinical advances such as the decision by the Human Fertilisation and Embryology Authority (HFEA) to allow mitochondrial donation, in which mtDNA from a female donor is introduced to an embryo to correct mitochondrial defects.

This research suggests that clinicians should assess the function of TDP1 and mitochondrial TOP1 before mitochondrial donation takes place, to ensure the success of this procedure, adds El-Khamisy.

Even if the new embryo has healthy mitochondrial DNA from the donor, it could still have defective TDP1 or mitochondrial TOP1 from the recipient, since they are both produced by the DNA in the cells nucleus, so mitochondrial DNA damage could still take place over time, and cause disease.

A Wellcome Trust Investigator Award and a Lister Institute of Preventative Medicine Fellowship supported the work. The University of Sheffield led the study in collaboration with the University of Newcastle, the University of Sussex, RAFT, Zewail City of Science and Technology in Egypt, and St Jude Childrens Research Hospital in the US.

Source: University of Sheffield

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Mitochondria use 'toolkit' when free radicals attack - Futurity: Research News

Magdalena Abakanowicz, obituary: The Polish sculptor’s work – The Independent

Magdalena Abakanowicz, who has died at the age of 86, was a sculptor whose work spoke of freedom and repression. Her looming, headless figures and haunting, monumental textile configurations explored the human condition and the relationship between man and nature.

In Chicagos Grant Park is Agora, 106 headless standing bodies, each nearly nine feet high. Its genesis, she said, lay in her experiences of the Second World War and the decades of communist rule she endured in her native Poland: I lived in times which were extraordinary by their various forms of collective hate and collective adulation, she said. Marches and parades worshipped leaders, great and good, who soon turned out to be mass murderers. I was obsessed by the image of the crowd.

Another series, Backs, was just that: pieces of sackcloth sewn together in representations of the human torso seen from behind, bent over in prayer, supplication or submission. The face can lie, she said. The back cannot. I was asked by the public, Is it about the concentration camps in Poland? Is it a ceremony in old Peru? Is it a ritual in Bali? To all these questions, I could answer yes because my work is about the general problems of mankind.

She was born Marta Abakanowicz in 1930 into an aristocratic family in Poland her father, the son of a Czarist general, claimed to be descended from Genghis Khan, while her mother came from Polish nobility and she was raised on her grandfathers estate 125 miles from Warsaw.

Her privileged upbringing came to an abrupt end when the Second World War broke out: drunken German soldiers broke into their house and shot her mother, Helena, in the arm, severing it. The family survived, but fled to Warsaw when Soviet troops began their westward advance on Berlin, and Marta worked as a nurses assistant treating the wounded during the failed Warsaw Uprising.

At wars end, as the Communists took over, the family, fearing class war, fled from the capital and established themselves near Gdansk, where Marta who changed her name to Magdalena to break with her past studied art. Pretending to be a clerks daughter, she then enrolled at the Warsaw Academy of Fine Arts, but by then the state-enforced socialist realism was in full swing, and she was turned down for the sculpture course, and concentrated instead on watercolours and gouache works daubed on bedsheets: It was almost forbidden to talk about mystery, she recalled. I did.

In 1965 she married an engineer, Jan Kosmowski (who survives her). Unsurprisingly, she encountered much resistance to her work from the Polish authorities. In 1960 one of her shows was banned from opening after an official, displaying spectacular and presumably wilful wrong-headedness, condemned it as formalist concerned purely with form. But she established an international reputation and began working increasingly abroad. In 1972 she wrapped Edinburgh Cathedral in coils of rope to resemble, she said, a petrified organism.

In Britain her work can currently be seen at the Tate Modern in London. Embryology is an example of what she called her Abakans, woven pieces made from sisal taken from ships ropes, hemp and cotton gauze, pieces she described as monumental, soft and erotic. In Embryology, the pieces are like boulders strewn across the gallery in mounds. I turn sculpture from an object to look at into a space to experience, she said. Every sculpture can be turned into decoration. But if you have 100, you are confronted by them and must think and imagine and question yourself. This is what I want.

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Magdalena Abakanowicz, obituary: The Polish sculptor's work - The Independent

Navigating the moral maze of driverless vehicles: Safety, risks and regulation – Lexology (registration)

Driverless vehicles continue to raise difficult legal and moral questions around safety. What are the regulatory implications for this fast-paced industry?

Autonomous vehicles (AV) that require no input from human occupants are currently being tested on public roads. Experimental prototypes, still closely supervised by people, are already mixing with ordinary traffic in parts of the US, Canada, UK, Sweden, Germany and Japan.

Technology giant Google alone has clocked up more than 2.2 million miles of autonomous testing[1] since it began developing its technology in 2009. It has now launched a new company, Waymo, to commercialise the technology. Other participants - including manufacturers like Volvo, parts suppliers such as Bosch and service providers like Uber - are pursuing their own ambitious development projects.

The arrival of autonomous vehicles as either purchasable products or hireable services now seems inevitable. However, in addition to the obvious technological challenges, driverless vehicles also raise a host of legal and moral questions. Our roads, our laws and our expectations have all been shaped by more than a century of vehicles controlled by human beings, with all their foibles and failings. Adding robotic cars, buses and trucks to the mix is not going to be trivial.

"There are certain areas of the law that are well equipped to deal with new technology, such as the patent system," notes Daniel Cole, an intellectual property partner at Gowling WLG. "But the archaic language of traffic laws that talk about a vehicle being under a person's control - that's all going to have to be completely revamped. And if you've ever watched anything move through a legislature, you'll know that's not happening in a month. That's years and years of work."

Setting the legal framework

Legal questions run from relatively minor issues, such as who pays for speeding fines, to deep moral questions about putting one life ahead of another in an accident.

One potentially tricky area is how to deal with rules that sometimes need to be broken. "Imagine an AV sitting at a red traffic light while an ambulance is trying to get through, refusing to move because it's been told it can't run through a red light. Meanwhile a patient is dying," says Cole. "There has to be a way to say it's OK to have that technical violation in these circumstances. But that's tricky because there are endless possibilities."

Liability when things go wrong is another area that is expected to create challenges. "There's going to be a shift in liability from the driver to the manufacturer or the people who market these products," observes Andr Rivest, Gowling WLG partner and head of its automotive group in Canada. Especially in the early days of adoption, when AVs and human drivers interact, it may be difficult to establish exactly who is liable for what, he cautions.

Putting members of the public in driverless vehicles will also require crossing a Rubicon that manufacturers - and their lawyers and insurers - may find unnerving. "If you look at today's features, like lane departure warning, they all come with disclaimers warning that they don't replace the driver's responsibility," notes Cole. "At some point we're going to flip that on its head and say that manufacturers are in control of the car. That's a huge mind-shift."

Rivest agrees. "The transition from lower level autonomy to full autonomy is where it's really delicate, and that's what we are beginning to address," he notes. "How should an AV react if a small child runs out after a ball and the car can't stop in time, but if it veers to the side it will run down an elderly couple? Who will make these decisions?"

Redefining risk

People are fallible and human error accounts for an estimated 94% of crashes, according to figures published in the US. To limit the danger, we expect drivers to exercise good judgement and behave as responsibly as possible. Highway patrols, traffic cameras, fines and the threat of imprisonment back up that requirement, but we also acknowledge that human skill is variable. We simply live with the risk that some drivers will make fatal mistakes behind the wheel.

Yet we tend to be less willing to accept risks, even of a much lesser scale, when they are posed by machines. We expect dangers in equipment to be spotted and removed, preferably before anyone is hurt.

Similarly, the knowledge that computerised systems can react more quickly than human drivers in an emergency has led to hopes that AVs might dramatically reduce the overall frequency of accidents. But this potential has also fuelled speculation that driverless vehicles will need to include a "moral algorithm" to determine how they should react when human life is at stake. After all, an AV may need to decide whether to protect occupants at the expense of bystanders, for example.

"When cars crash today, people act instinctively - they don't make conscious decisions," points out Stuart Young, head of automotive at Gowling WLG in the UK. "But when you program a car, you are sitting at a computer writing the code, and you have every opportunity to make a calculated decision about what the car should do in given circumstances. I think there will be a moral judgement on someone who's been able to contemplate and come to a conclusion."

'Intelligent' software systems

However, the situation may not be so clear cut. It is likely that autonomous vehicles will rely on complex software techniques, such as neural networks or genetic algorithms, which can acquire expertise without human reasoning. For example, a software system might "learn" the capability to recognise a cyclist by being provided with many thousands of example images, rather than any formal definition composed by a programmer. Internally, the software will build up a complex mathematical model allowing it to successfully recognise new images of cyclists. However, there will be no step-by-step reasoning in the software that can be unravelled and understood.

Similar machine learning techniques are likely to be employed extensively within AV development, ultimately dictating how the vehicle will react to unfolding circumstances. A software model will be built up over millions of miles of testing, helping the AV to interpret any consciously coded set of rules.

What results is a mire of moral questions that include not just which decisions ought to be made but how they might be reached. Some types of programming might be subject to debate.

"Regulation needs to get on top of this," says Young. "It needs to get ahead of it. Because at the moment there's nothing giving a clear steer as to who's going to take responsibility for what, or whether all decisions are going to be left to manufacturers."

That path, as Cole notes, means waiting for things to go wrong to establish legal precedents that might provide a measure of clarity.

International regulation models

Gowling WLG is calling for an alternative approach that recognises the need for affirmative action by governments around the world. Pre-emptive regulation of autonomous vehicles need not hold back their development, argues Young. Instead, clarity over expectations and responsibilities would likely resolve some hard-to-quantify business risks that might otherwise stand as stumbling blocks.

"What we've been looking at is asking government to set up an independent agency to regulate the technology," says Young. "In the UK, we have the HFEA (Human Fertilisation and Embryology Authority), which may seem like an odd analogy, but it has been successful. There's a lot of ethics involved in embryology and development, but it was set up as an independent government agency with the right representation. It's broadly seen as having done a very good job of allowing development whilst tracking and reflecting ethical concerns in society. And that's what we need for the moral aspects of the algorithms that are going to be developed."

It is also vital to recognise that the vehicle industry is a global one, where international agreements make more sense than local regulations. Given that vehicles can drive across national borders, useful models for regulation may also be found in the air transport industry, where international pacts govern corporate behaviour and limit liability for carriers.

Vehicles are already more heavily regulated than other consumer products, with type approval to ensure compliance with national and international regulations, and compulsory safety recalls to correct serious errors, so any move to regulate the programming of AVs would not be without precedent.

Today, most countries with a significant automotive manufacturing base have started to grapple with the issues raised by AVs, with varying levels of ambition. In the UK, for example, the Department for Transport recently carried out a consultation[2] to examine what changes might be needed to insurance, type approval regulations and the national Highway Code.

"The most comprehensive exercise I've seen is in the US," says Young. "The National Highway Traffic Safety Administration (NHTSA) has done a pretty thorough job with the Federal Automated Vehicles Policy[3], issued in September. It's a root and branch review of what needs to be done to create the right legal framework in the US (including a model state-by-state code), what should be retained at a federal level, and what needs to be set down in terms of vehicle safety. Of course, there have been critics of the policy, particularly around the data sharing aspects, and with the new Trump administration there is some doubt over whether it will get any further Federal support."

As technology advances, society is likely to recognise that AVs - even those without a verifiable moral algorithm - can save lives simply by reacting more swiftly, more decisively and more accurately to sudden unforeseen danger. The question that then arises is: how much safer than human drivers do AVs need to become before we are morally obliged to adopt them?

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Navigating the moral maze of driverless vehicles: Safety, risks and regulation - Lexology (registration)

Cheshunt fertility clinic under investigation for ‘paying poor women … – Hertfordshire Mercury

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A fertility clinic in Cheshunt is under investigation after it found itself at the centre of a sting by a national tabloid newspaper.

The Daily Mail alleged that the Herts and Essex Fertility Centre was one of three to offer financial incentives to poor women to donate their eggs - a practice which can be illegal.

The Human Fertilisation and Embryology Authority (HFEA), which regulates clinics, has contacted the facility and will be conducting an investigation.

Undercover reporters from the paper posed as couples seeking IVF treatment at the Cheshunt clinic, which lies a stone's throw from the Broxbourne Borough Council offices in Churchgate.

They claim they were offered cheap, or free, treatment in exchange for the donation of half the eggs the female partner would produce. Those eggs would then be used to provide IVF for other couples.

READ MORE: Brave Cheshunt boy comes through life-changing 75k operation

Clinics are restricted by law from offering financial incentives for donations, and one doctor at a clinic in Darlington told the reporter she should refrain from putting money on the consent form.

The chairwoman of the HFEA Sally Cheshire said: "We are very concerned by the allegations made in this investigation. At the HFEA our priority is the best possible treatment and care for patients and donors.

"If any patients at these clinics have worries about their care, they should contact us while we investigate further. We have already contacted the clinics involved and our inspectors will investigate each allegation. If we find poor practice in a clinic, we will take regulatory action."

READ MORE: Watch Stavros Flatley lose seven inches from his waist with new treatment

Despite the HFEA confirming to the Mercury it has contacted the Herts and Essex Fertility Centre, the clinic's marketing manager Sally Day denied this is the case.

Consultant gynaecologist David Ogutu said the facility complies with all regulations and the scheme it offers is legal.

He added: "It is important to stress that egg share cycles involve treatment of only one recipient and one egg donor. Half the eggs received from an egg share donor are used to treat only one other patient, the recipient.

"The payment received from the recipient covers the donor's costs. At Herts & Essex Fertility Centre we are immensely proud to help hundreds of couples to have babies, who cannot afford fertility treatment and who through no fault of theirs, are not eligible for NHS funded treatment.

"Only through egg sharing can some couples hope to have a loving family and we have nothing to be ashamed of."

Health Secretary Jeremy Hunt said he would be watching the HFEA investigation very closely. He added: "I will be paying close attention to the findings and in the meantime urge anyone with concerns to contact the HFEA without delay.

"The Mail's findings are both serious and worrying and they are right to have brought them to public attention."

According to the Daily Mail report, a poster in the waiting room at the Herts and Essex clinic advertises the scheme to prospective parents who cannot get NHS funding.

IVF can cost couples tens of thousands of pounds so the scheme is likely to be a significant draw for the less well-off.

A nurse in Cheshunt allegedly told the reporters egg donation was "just like giving blood" and reassured them that "an egg isn't a baby".

Potential donors at the clinic are reportedly given one hour of counselling about the experience of another couple raising their genetic children.

Mr Ogutu said: "Research has clearly shown that egg sharing women have similar success rates to that of comparable non-egg sharing women undergoing IVF treatment.

"So those women are not compromising their chances of success and on top of that, are getting their treatment free.

"As far as the mandatory independent free counselling is concerned, we do not dictate how many sessions egg sharing couples have.

"It is purely between the counsellors and the couples to decide if they require more sessions as we have no limit as to the number of sessions."

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Cheshunt fertility clinic under investigation for 'paying poor women ... - Hertfordshire Mercury