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Dartmouth-Hitchcock discontinuing infertility program leaving patients with concerns – NH1 News

LEBANON Dartmouth-Hitchcock Medical Center is discontinuing its Reproductive Endocrinology and Infertility (REI) program at the end of this month, leaving some patients with questions.

The Medical Center has evaluated its REI program over the past few months and determined that they cannot offer the quality of care that the patients need and deserve without appropriate resources, said Rick Adams, Director of External Relations for Dartmouth-Hitchcock.

News of this came as a shock for at least one patient who contacted NH1 News curious as to why the public found out before the patients did. Adams did not answer specifically why the Medical Center did not contact patients first, but did say that they were in the process of notifying patients as of 1 p.m. Tuesday, although he did not say how.

Dartmouth-Hitchcock is working towards transitioning patients to appropriate programs around the region to continue their care, Adams added.

The patient, who asked to remain anonymous, expressed concerns over how the Medical Center will ensure that her embryos, along with other patients, don't die during the transfer process to different facilities. Adams did not go into specifics regarding this question.

"While the infertility program itself will be discontinued, our Embryology and Andrology laboratory will remain available to our patients and to the programs to which they transition, as part of their continuum of care," Adams stated.

The program is coming to an end effective May 31, providing three weeks for patients to find other arrangements. Adams did not specify why the Medical Center selected this date.

Dr. Edward Merrens, Dartmouth-Hitchcock's chief clinical officer, told the Valley News the decision stemmed from difficulty in finding "the right amount of staffing" to support the work, which can involve monitoring patients seven days a week. Merrens added that the program made a profit and that financial considerations did not factor into the decision to close the program.

Adams did not answer why profits from the program were not put towards more staffing to keep the program running.

"We understand the impact this difficult decision has on our infertility patients. In the end, it is clear that we cannot sustain the program, and our belief is that ending our REI program and helping our patients find a program that can support them is in those patients best interest," Adams said.

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Dartmouth-Hitchcock discontinuing infertility program leaving patients with concerns - NH1 News

Growth in Stem Cell Research – Financial Tribune

Iran is expanding investment in stem cell research and its application in various therapies, particularly for hard-to-treat diseases, through the Office of the Vice- Presidency for Science and Technology. As a result of the increase in the number of companies active in the domain of stem cells in the past three years, more than 400 products are processed in the country, indicating a multifold growth compared with the eight-year tenure of previous administration when there were fewer than 50 knowledge-based firms in total.

There are over 40 knowledgebased firms in the field of stem cell and regenerative medicine alone in Iran today, said Amir Ali Hamidiyeh, secretary of the Headquarters for Development of Stem Cell Science and Technology (HDSCST). He made the statement at a press briefing for the second National Festival and International Congress on Stem Cell Sciences and Technologies and Regenerative Medicine to be held July 13- 15 in Tehran, Mehr News Agency reports. According to the conference secretariat, 1,444 people have signed up to attend the event from across the world, including from Iraq, India, Pakistan, Jordan, Russia, Australia, Germany, China, Britain and South Korea. They all are among their countrys respected figures in centers with high academic standing.

The congress is co-sponsored by the Vice-Presidency for Science and Technology and Council on Development of Stem Cell Sciences and Technology. So far, eight stem-cell therapy products for use in hospitals have been produced at the HDSCST laboratories. Manufacturinglicenses have been granted for anadditional number, while others are on thewait list.

Prior to 2014, only 25 knowledgebased companies had applied to operate in this field, of which only one was actively producing quality stem cell products, Hamidiyeh pointed out.

But since then, over 25 workgroups have been formed in cooperation with experts in the specific sciences. Stem cells are cells that have the ability to divide and develop into many different cell types in the body during early life and growth. Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use.

Future of Medicine in Stem

Cells The future of medicine is interrelated with stem cell therapy and the treatment ofrefractory and incurable diseases is in this field of medicine, according to Dr. Ahmad Vosouq Dizaj, the clinical deputy of Royan Institute. Having access to engineering sciences as well as the combination of biology and medicine can play a crucial role in redressing health problems, he said. Stem cells have the ability to replace damaged cells and treat disease. They can also be used to study diseases and provide a resource for testing new medical treatments. The use of stem cells reduces the risk of viral diseases transmission and incidence of Graft Versus Host Disease (GVHD). The ability to perform organ transplants is among the benefits ofumbilical cord blood transfusion.Using stems cells is also one of thebest ways to treat blood diseases sincethe method has a success rate of 70%worldwide.

Storage of stem cells is a valuable investment. So far, 27 cord blood banks have been launched across the country. There are two types: public and private banks for stem cell storage. The former does not charge a fee for storage. But in the latter, the cost of collection and genetictesting is about $645 and the annualcharge for storage is $33, according toISNA.Iran is a leading country in biomedicalresearch. Researchers and physicians have been successfully performing bone marrow transplants during the past fewyears.Irans stem cell research is centeredat the Royan Institute for ReproductiveBiomedicine, Stem Cell Biology andTechnology, located in northern Tehran.

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Growth in Stem Cell Research - Financial Tribune

Lithium May Protect Nerve Cells After Traumatic Brain Injury – ReliaWire

A drug used to treat bipolar disorder and other forms of depression may help preserve brain function and prevent nerve cells from dying in people with a traumatic brain injury.

Scientists discovered that lithium and rapamycin, a treatment for some forms of cancer, protect nerve cells in the brain and stop the chemical glutamate from sending signals to other cells and creating further brain cell damage.

Many medications now used for those suffering with traumatic brain injury focus on treating the symptoms and stopping the pain instead of protecting any further damage from occurring. We wanted to find a drug that could protect the cells and keep them from dying,

says lead author Bonnie Firestein, professor of cell biology and neuroscience at Rutgers University-New Brunswick.

Traumatic brain injury (TBI) is a major cause of death and disability in the United States with an estimated 1.7 million people sustaining an injury every year, according to the Centers for Disease Control and Prevention. About 30 percent of all deaths due to injury are due, in part, to a TBI.

TBI symptoms can include impaired thinking or memory, personality changes, and depression, as well as vision and hearing problems. The CDC reports that every day 153 people in the US die from injuries that include a TBI, with children and older adults at the highest risk.

When a TBI occurs, a violent blow to the head can result in the release of abnormally high concentrations of glutamate, which under normal circumstances is an important chemical for learning and memory. But an overproduction of glutamate, Firestein says, causes toxicity which leads to cell damage and death.

The research shows that when these two FDA-approved medications were added to damaged cell cultures in the laboratory, the glutamate was not able to send messages between nerve cells which stopped cell damage and death.

Further research needs to be done, in animals and humans, to determine if these drugs could help prevent brain damage and nerve cell death in humans after a traumatic brain injury.

The most common traumatic brain injury that people deal with every day is concussion which affects thousands of children each year, Firestein says. Concussions are often hard to diagnose in children because they are not as vocal, which is why it is critical to find drugs that work to prevent long-term damage.

The New Jersey Commission on Brain Injury Research funded the work.

Image: Dr David Furness, Wellcome Images

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Lithium May Protect Nerve Cells After Traumatic Brain Injury - ReliaWire

North Quincy High instructor named Mass. Teacher of the Year – The Boston Globe

Cara Pekarcik, 2018 Massachusetts Teacher of the Year, stood amid her grateful and applauding students on Tuesday.

QUINCY As students took their seats in the bleachers and the pep band played, it felt like a homecoming rally.

But instead of cheering on the Red Raiders of North Quincy High School, students had gathered to thank their teachers for their hard work and dedication.

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In honor of National Teacher Appreciation Day, the 2018 Massachusetts Teacher of the Year was announced here Tuesday. The winner was kept secret, and speculation was running wild. But when Cara Pekarciks name was called, it didnt come as a surprise.

I apologize to anyone I had to lie to over the past few days, said Pekarcik, a biology teacher. Without a doubt, my biggest thanks goes to students here at North Quincy High. There is kindness, respect, and empathy in this group of students.

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Kennex Lam, 17, said science had always been her weakest subject before she took Pekarciks class. At the start, she found cell biology really confusing. But Pekarcik would stay after school to tutor her, Lam said.

She is never one to deny her students help, Lam said.

Before becoming a teacher, Pekarcik had worked as a biologist, and students praised her ability to make biology seem fun and relevant.

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Everyday she makes the class interesting, she just brings it to life, said Maria Zraizaa, 16. She actually cares about people, and you can tell that she cares about what you do. Shes just so passionate about everything.

Talia Viera, 16, said Pekarcik made her look forward to science class, something she didnt think likely.

I used to not like science as much, but now its not one of the classes I go to just to get it over with, she said. I go and I actually enjoy being there. She really makes what we learn interesting.

Elizabeth DiMattio, 17, who took Pekarciks class last year, said she often turned to Pekarcik for guidance.

There was one time I was absolutely freaking out about an essay, she just sat me down and was like You need to calm down. She guided me through it, DiMattio said.

After the assembly, Pekarcik said she was thrilled by the honor. She said she often tells her students they can take an interest in science without being an expert.

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North Quincy High instructor named Mass. Teacher of the Year - The Boston Globe

Lithium may save nerve cells after brain injury – Futurity – Futurity: Research News

A drug used to treat bipolar disorder and other forms of depression may help preserve brain function and prevent nerve cells from dying in people with a traumatic brain injury.

Scientists discovered that lithium and rapamycin, a treatment for some forms of cancer, protect nerve cells in the brain and stop the chemical glutamate from sending signals to other cells and creating further brain cell damage.

Many medications now used for those suffering with traumatic brain injury focus on treating the symptoms and stopping the pain instead of protecting any further damage from occurring, says lead author Bonnie Firestein, professor of cell biology and neuroscience at Rutgers University-New Brunswick. We wanted to find a drug that could protect the cells and keep them from dying.

Traumatic brain injury (TBI) is a major cause of death and disability in the United States with an estimated 1.7 million people sustaining an injury every year, according to the Centers for Disease Control and Prevention. About 30 percent of all deaths due to injury are due, in part, to a TBI.

TBI symptoms can include impaired thinking or memory, personality changes, and depression, as well as vision and hearing problems. The CDC reports that every day 153 people in the US die from injuries that include a TBI, with children and older adults at the highest risk.

When a TBI occurs, a violent blow to the head can result in the release of abnormally high concentrations of glutamate, which under normal circumstances is an important chemical for learning and memory. But an overproduction of glutamate, Firestein says, causes toxicity which leads to cell damage and death.

The research, reported in Scientific Reports, shows that when these two FDA-approved medications were added to damaged cell cultures in the laboratory, the glutamate was not able to send messages between nerve cellswhich stopped cell damage and death.

Further research needs to be done, in animals and humans, to determine if these drugs could help prevent brain damage and nerve cell death in humans after a traumatic brain injury.

The most common traumatic brain injury that people deal with every day is concussion which affects thousands of children each year, Firestein says. Concussions are often hard to diagnose in children because they are not as vocal, which is why it is critical to find drugs that work to prevent long-term damage.

The New Jersey Commission on Brain Injury Research funded the work. The commission is funded, in part, by traffic tickets for moving violations like speeding, using a cell phone, or driving without a license, and provides $1 to the fund from every ticket issued.

Source: Rutgers University

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Lithium may save nerve cells after brain injury - Futurity - Futurity: Research News

‘Grey’s Anatomy’ Season 13 Episode 23 Promo: Stephanie Takes a Fatal Fall? – Wetpaint

Credit: Richard Cartwright/ABC 2017 Disney | ABC Television Group. All rights reserved.

Greys Anatomy Season 13 has been writing Stephanie Edwards off the show for ten episodes now, but perhaps the end of her storyline will take a violent turn.

A new promo suggests Steph will be going out not with a whimper but with a splat.

Stephanie has become increasingly disillusioned with surgery, and now shes even suspended from the OR, so a career change could be nigh.

But this promo for Season 13 Episode 23 airing this Thursday, May 11 has us worried this doc will actually fall to her death.

In the teaser, we see Stephanie treating her potential murderer, a patient at Grey Sloan Memorial.

Help me, he beseeches her.

Were guessing hes the dangerous patient mentioned by ABCs synopses for both this episode and the May 18 season finale perhaps hes mentally ill.

In the next shot, the man is throwing Stephanie against a wall and pressing a sharp object to her throat.

Next, we see her hurriedly open a door with a keycard. Then, we see her stagger down a flight of stairs in his grasp, followed by a vertiginous shot looking straight down the stairwell.

Above the tense music, we hear a snippet of dialogue. It sounds like shes saying, I cant.

Then comes the scariest shot: The patient is seemingly pushing Stephanie so that shes leaning far out over the stairway railing.

The rest of this promo hypes another major plot twist. At home, Owen answers a knock at the door, and an offscreen male voice asks, Owen Hunt?

Cut to: a shot of Owen sobbing, with Amelia comforting him.

Could we finally be seeing the return of Megan Hunt, Owens sister and Nathans ex? Megan has been missing since their days serving as Army docs together she disappeared on a helicopter trip through unprotected airspace.

If youll recall, Megan discovered Nathan was cheating on her, and Owen encouraged her to board that ill-fated chopper just to get away from Nathan.

Fans have speculated that Megan is due for a reappearance, especially now that Nathan is getting cozy with Meredith. Your new boyfriend finding his ex-girlfriend after years of her being MIA? Thats peak Shondaland, if you ask us.

And we havent even mentioned the first clip of this promo, in which Bailey announces a code orange situation, which often means hazardous materials are at play.

If thehottest Season 13 finale spoilers are any indication, those hazardous materials are of the flammable persuasion

And that would mean Steph and Owen arent the only docs rocked by drama as Season 13 concludes!

Greys Anatomy Season 13 Episode 23 True Colors airs Thursday, May 11 at 8 p.m. ET on ABC.

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'Grey's Anatomy' Season 13 Episode 23 Promo: Stephanie Takes a Fatal Fall? - Wetpaint

‘Grey’s Anatomy’ Finale Has ‘Amazing Cliffhanger’ Before ‘Spectacular’ Season 14 – Moviefone

The "Grey's Anatomy" Season 13 finale will be "very on fire." Literally? We'll see.

Episode 24, "Ring of Fire" (hint, hint?) airs Thursday, May 18 with this synopsis: "The doctors' lives are at risk after a dangerous patient escapes the hospital room. Alex must make a hard choice in his relationship with Jo while Meredith has some big news for Nathan that brings things to a turning point."

Executive producer Debbie Allen (Catherine Avery) directed the finale, and she told Entertainment Weekly, "There's actually two events going on at the same time that are pretty big that affect the entire hospital community. You should be worried. There's cause for worry. There's an amazing cliffhanger that will have everybody thinking, 'Wow, where is this going?!'" She added that they'll "plant more seeds that fuel the fire for what is going to happen next season."

Allen added, in a separate EW interview, "I think Season 14 is going to be spectacular. We're planting some seeds that you won't see coming, but you will be waiting to see how it's all going to play out." Show creator Shonda Rhimes is the one who teased, to EW, "Debbie Allen and I like to say that the episode is on fire. That's the only way we're going to describe it. It's a pretty exciting episode that's very on fire."

Kelly McCreary (Maggie Pierce) previously teased the "event" of the finale, telling EW, "It's a great big event that will keep everyone on the edge of their seats. It really is shocking. There were so many gasps of horror and surprise at the table read. It was delicious. It was just so much fun." A while back, Kevin McKidd (Owen Hunt) told TVLine the finale would be "pretty dramatic and pretty intense. It's pretty dark and very good."

We're excited to see the cliffhangers, and what they mean for Season 14, but it's the relationship stuff with Mer, Riggs, and Jolex that really has us curious.

Before we get to the finale, we have one more episode to get through, "True Colors," which airs May 11 with this synopsis: "The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news that pushes Amelia to step up to support him, and Alex attends a medical conference after making a shocking discovery."

Jo's hubby, comin' in hot? Hmm..."Grey's Anatomy" airs Thursdays at 8 p.m. on ABC.

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'Grey's Anatomy' Finale Has 'Amazing Cliffhanger' Before 'Spectacular' Season 14 - Moviefone

Stanford biologist Robert Sapolsky takes on human behavior, free will – Stanford University News

Robert Sapolsky (Image credit: L.A. Cicero)

Robert Sapolsky is a lot of things: a MacArthur Fellow who spent years studying a troop of baboons in Kenya, a neuroendocrinologist who changed the way we think about stress and the brain, an accomplished columnist and writer of popular science books. He is also a professor of biology at Stanford who has long been interested in what animals can tell us about our own behavior.

Most recently, Sapolsky has been reflecting on the origins of human behavior, starting deep in the brain moments before we act and working his way millions of years back to the evolutionary pressures on our prehistoric ancestors decisions, with stops along the way to consider how hormones, brain development and social structures shape our behavior. He also has been thinking about free will and comes to the conclusion, based on the biological and psychological evidence, that we do not have it.

On the occasion of his latest book, Behave: The Biology of Humans at Our Best and Worst, Stanford News Service interviewed Sapolsky about science, the need to be behavioral biologists and what to do about justice if, as Sapolsky argues, we do not have free will.

Youve advanced the idea that we cant understand human behavior by studying it at just one level that, for example, we cant understand politics without studying neurons, brain chemistry without studying psychology, or perhaps even humans without studying apes. Does that mean that weve been studying behavior the wrong way? Are university departments too compartmentalized to see the forest for the trees?

Well, theres nothing particularly special about the idea scientists thinking about the bases of behavior know that you have to be multidisciplinary. There are entire journals that enshrine that concept, for example, Psychoneuroimmunology or Brain, Behavior and Evolution, and every university of note is overflowing with interdisciplinary programs.

Where the contrast comes in is with individual scientists research. Of necessity, a scientist typically studies one incredibly tiny sliver of some biological system, totally ensconced within one discipline, because even figuring out how one sliver works is really hard. There are not many scientists who would argue that their sliver is the only thing that should be studied just that its the most important, which sure makes sense, if they just spent their last seven decades obsessing over that sliver.

Is that a problem?

Its not a problem if all they do is talk and think about sliver X. But potentially a definite problem if they think larger and their sliver X-centric view of the universe is distorted.

All roads in human behavior seem to lead to its complicated. Out of the mess of things that combine to create our best and worst and typical behavior, what do you think is most important for ordinary people to know? What about policymakers or other scientists?

I think its the same for both groups, which is that were all behavioral biologists when we serve on juries, when we vote for whether government funds should be spent to try to correct some societal ill, when we deal with an intimate with a mental illness, we are tacitly deciding how and how much our behavior is constrained by biology. So we might as well be informed behavioral biologists. And one thing that involves is being profoundly cautious and humble when it comes to deciding you understand the causes of a behavior, especially one that we judge harshly.

What does that suggest about judicial sentencing rules or the death penalty, for example?

Basically, that the criminal justice system is staggeringly out of date in incorporating neuroscience into its thinking. As one flagrant example, the gold standard for determining whether someone is so organically impaired that they cant be held responsible for their criminal actions the MNaghten rule concerning an inability to tell the difference between right and wrong is based on the case of a man by that name, almost certainly a paranoid schizophrenic, from the 1840s. The 1840s!

What are the most important questions that remain?

For me, the single most important question is how to construct a society that is just, safe, peaceful all those good things when people finally accept that there is no free will.

Thats a tall order, given that philosophers let alone politicians and activists have trouble deciding what justice and free will mean.

A tall order, indeed, because words like justice, punishment, accountability become completely irrelevant as irrelevant as if a car that has damaged brakes and is dangerous to drive is thought to be accountable for being dangerous, and that justice is served when the car is punished by locking it up in a garage and not driven.

And its equally important and challenging to realize that free will is also irrelevant to our best as well as our worst behaviors. And thus where praising seems as irrelevant as praising a car for having a strong work ethic and admirable gratification postponement when it makes it up the top of a steep road. Or if you give a car preferential treatment if it was manufactured with a really attractive hood ornament.

Yes, a very tall order, and Im not sure if it is achievable.

Sapolsky is also the John A. and Cynthia Fry Gunn Professor, a professor of neurology and neurological sciences and of neurosurgery, and a member of Stanford Bio-X and the Stanford Neurosciences Institute.

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Stanford biologist Robert Sapolsky takes on human behavior, free will - Stanford University News

Global genetics – The Northern Daily Leader

8 May 2017, 9:40 a.m.

Glenisa Angus Studs 2017 catalogue boasts 44 young black bulls that are the sons of 11 individual sires sourced from Australia and overseas

Top line-up: Aaron and Ced Wise, Glenisa Angus Stud, Glen Aplin with a group of youngsters destined for the annual Glenisa Angus Sale, on May 12. Photo: Kent Ward

Glenisa Angus Studs 2017 catalogue boasts 44 young black bulls that are the sons of 11 individual sires sourcedfrom Australia and overseas.

Eleven international, colonial and homebred sires feature in the annual sale, held at 1pm on May 12 at Glenisa,Glen Aplin, Queensland.

Vendors, Ced and Rowena Wise and family have been buoyed by client feedback and increaseddemand for their physical product due to the change of date at the 2016 sale.

Last year, bulls soldto areas of the tablelands between Glen Innes and Stanthorpe, all parts of the northern rivers ofNSWand as far north as central Queensland.

Sires represented include new global introductions in the form of Sydgen Black Pearl 2006, SChisum 6175, Sitz Upward 307R, Jindra Double Vision and Remitall H Rachis 21R.

Thesebulls are joined by outsourced introductions like DSK GDK Good Go G133, RaffDynamite G156, DSK RR Feel Good F36 (AI,ET) and Booroomooka Hyperno H605 (AI) alongwith the homebred retaineeS, Glenisa Felix F017 (AI, ET) and Frederick F009 (AI, ET).

All on offer have been vaccinated with three day, blooded with three germ, five in one and vibrio.The entire team has been semen tested and soundness evaluated and tested Pestivirus negative.

The bulls preparation is one of a silage diet for nearly three months. Theyhave current Angus Group Breedplan figures, scan data including live weight, scrotalmeasurements.

Run and grown out on local harder country, the bullsgut has been fully protectedwith a growing out period and they have been educated and handled and worked with dogs,horses and bikes.

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Global genetics - The Northern Daily Leader

Genetics and Inheritance of Moebius Syndrome – News-Medical.net

Most cases of Moebius syndrome are spontaneous, with no family history and no known genetic cause. In certain rare cases, the disorder has been associated with defects in chromosomes 3, 10, and 13. The Online Mendelian Inheritance in Man (OMIM) database lists the gene map locus 13q12.2-q13 as having significance for Moebius syndrome.

Mutations of the genes PLXND1 and REV3L have also been pinpointed as being associated with Moebius syndrome, based on animal studies showing nerve deficits typical of the syndrome when mutations of those genes are introduced in animals.

The significance of the genes PLXND1 and REV3L is as yet unknown, and their involvement sheds little light on the origins of the disease, since they regulate different pathways. PLXND1 is connected to neural migration during hindbrain development and REV3L plays a role in DNA translesion synthesis, a process which repairs damaged DNA.

PLXND1 has been mapped to chromosome 3q22.1. A novel mutation of PLXND1 was found in a patient diagnosed with Moebius syndrome in 2015. Sequencing in 103 patients with Moebius syndrome identified one additional patient with a mutation of PLXND1.

Conflicting studies have mapped REV3L to 1p33-32 and chromosome 6q21. A variant of REV3L leading to decreased levels of the normal REV3L transcript was found in a patient diagnosed with Moebius syndrome in 2015. That same variant was found in sequencing studies in 6 other unrelated patients with Moebius syndrome. In another study 103 patients with Moebius syndrome were sequenced and 2 were identified with a new variant of the REV3L gene.

In rare cases where Moebius syndrome shows a familial inheritance pattern, it is inherited as an autosomal dominant trait. That means a single copy of the abnormal gene results in the manifestation of the disease and there is a 50% chance of passing it on to the offspring.

In one family, six people in two generations had palsy of cranial nerves VI and/or VII with skeletal or digital malformations. Nine others had digital anomalies without the cranial nerve involvement. Another family had three members with features of Moebius syndrome with mental retardation. However, these cases of inheritance are very rare.

Defects of chromosomes 1p34 and 13q13 were found in one family which had facial diplegia and flexion finger contractures in 7 members across 3 generations. In another case, a two-year-old girl with Moebius syndrome had a deletion of 13q12.2. These cases suggest that chromosome 13q12.2-q13 is of significance.

One boy with symptoms of Moebius syndrome had a reciprocal translocation on chromosomes 1 and 2. The locus a 1p22 was switched with 2q21.1.

In another case, Moebius syndrome with cleft palate, dextrocardia, mandibular hypoplasia, brain volume loss, and Poland syndrome was associated with another translocation involving 1p22. In that case, it was switched with 11p13. These cases may implicate 1p22 as a genetic cause of Moebius syndrome.

Thus genetic mutation, or a combination of one or more mutations and environmental factors, may cause a developmental defect of the hindbrain. This may occur through mechanisms such as disruption of blood flow to the brain during fetal development, leading to the manifestation of Moebius syndrome at birth.

Reviewed by Liji Thomas, MD

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Genetics and Inheritance of Moebius Syndrome - News-Medical.net