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11 Indefensible Izzie Stevens Moments on ‘Grey’s Anatomy’ (PHOTOS) – Wetpaint

Remember Dr. Isobel Stevens? That Greys Anatomy character who abruptly left the ABC hit seven seasons ago amid a flareup of behind-the-scenes drama?

Izzie did a lot of things right funded the clinic, gave her biological daughter a bright future, made Alex a better person, etc. but whats the fun in covering those?

No, today were talking about all her professional and personal missteps, from frivolous to frightful. Check out the gallery here to see 11 of them, presented chronologically.

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No wonder no one wanted to break bread together. Luckily for her, Burke swooped in to save the day and the roast turkey.

Looks like Santa threw up in here, George remarked.

Forget that transplant patient higher on the donor list, Izzie is in love! So she cut her paramours LVAD wire to put him first in line for a new heart.

Denny ultimately kicked a bucket, and his $8.7 million fortune went to Izzie. She kept the check on the fridge for a long time, and we pulled out our hair for a long time.

The Greys writers couldnt stop trying to make Gizzie happen, so for much of Seasons 3 and 4, we had to watch the characters fumble toward the realization they had zero sexual chemistry.

Denny appeared as a ghost to get Izzie to realize she had cancer but not before convincing Izzie to have sex with him.

Worse yet, she was involved with Alex at the time. (But is ghost sex cheating, technically?)

When Izzie told Cristina about her cancer diagnosis, Cristina pulled a lot of strings to get her a date with the best oncologist in Washington state, an appointment that Izzie brushed off. Why, girl, why?

Finally, to everyones relief, Izzie came around and accepted treatment.

This brings gallows humor to a whole new level. (Secretly, though, we love it.)

We get that Izzie had just had a brush with death, but making a medical error so grave that it costs a kidney transplant patient her spot on the donor list? Thats amateur hour for real.

Richard fired Izzie for that blunder, and she incorrectly assumed Alex was involved and left him. Yes, she left her own husband with nothing but a Dear John letter in his locker.

Izzie came back a couple of times that season but never achieved any semblance of closure with Alex before she vanished for good. Is she in Seattle? Did she get that job in Tacoma?

Well never know, because Katherine Heigl was desperate to leave Greys and Shonda Rhimes has never forgiven her.

Remember Dr. Isobel Stevens? That Greys Anatomy character who abruptly left the ABC hit seven seasons ago amid a flareup of behind-the-scenes drama?

Izzie did a lot of things right funded the clinic, gave her biological daughter a bright future, made Alex a better person, etc. but whats the fun in covering those?

No, today were talking about all her professional and personal missteps, from frivolous to frightful. Check out the gallery here to see 11 of them, presented chronologically.

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11 Indefensible Izzie Stevens Moments on 'Grey's Anatomy' (PHOTOS) - Wetpaint

Deciphering The Immunology Combo Avalanche – Seeking Alpha

As the nearly 800 currently ongoing studies involving anti-PD-(NYSE:L)1 agents combined with other approaches speed towards readout investors will be faced with a tough question: how precisely to interpret the overwhelming amount of data generated.

The issue took centre stage at a panel discussion at today's Sachs Associates Immuno-oncology Forum on the sidelines of the Asco meeting. It will be one of several things the industry will grapple with, though it is by now abundantly clear that there is no stopping the combo study runaway train.

That fact was illustrated in a report just published by EP Vantage, which showed that the absolute number of anti-PD-(L)1 combo trials under way - with numerous mechanistic approaches - had surged nearly fourfold since November 2015 to reach 765 in April.

Dr James Mul, from the Moffitt Cancer Center, told the Sachs conference that it was hard to imagine just how rapidly these trials were being conducted. In terms of subjects enrolled, he cited data showing that there were now over 250,000 patients in active immuno-oncology studies.

"But there will be no clear-cut direction as to where combo studies are heading until about 2019," he said. "There's still a way to go before we can make clear-cut decisions."

John Beadle, chief executive of Psioxus, whose oncolytic virus enadenotucirev is being combined with Bristol-Myers Squibb's (NYSE:BMY) Opdivo, called the expected surge of data an "exponential avalanche of information".

Still, most of these studies are too early to involve randomisation, and many are not designed to answer the simple, head-to-head question of whether A plus B is better than A or B alone. And, while it is clear than many combos will not work, what yardsticks should investors use to determine whether a combination has actually given an incremental benefit?

The panel suggested that one aspect of particular relevance should be to look at whether a study involves subjects who have already failed on a checkpoint inhibitor, or those who have shown resistance to immuno-oncology in general. Signs of efficacy in these patients would clearly be of interest.

IO-IO or back to basics?

Paul Rennert, chief executive of Aleta Biotherapeutics, who was co-chairing the panel with Dr. Mul, drilled down into the changing expectations behind the various checkpoint combination approaches.

He admitted to having been one of the people who two or three years ago had made much of the potential of combining immuno-oncology with immuno-oncology, assuming that novel targets like Ox40, GITR, Tim3, Vista and others were going to raise immune responses strongly and usher in a new wave of post-PD-(L)1 agents.

"We thought we were going to get response rates up. We're not seeing that yet," he admitted. "Perhaps it's too early."

On the other hand, perhaps it is checkpoint inhibitor combinations with more traditional approaches, such as small molecules or even simple chemotherapy, that investors should pay attention to. The surge in chemo combo studies was another key finding of the EP Vantage report.

This issue could feed into other important areas such as pharmacoeconomics: a chemo combo approach would clearly be cheaper than one combining two IO agents.

At a separate Sachs Forum discussion focused on deal-making, Timothy Herpin, head of UK transactions at Astrazeneca (NYSE:AZN), said there would likely be continued interest in non-IO mechanisms, but that these would play out in combination with an IO backbone.

Guillaume Vignin, head of IO licensing at Merck KGaA (OTCPK:MKGAF) (OTCPK:MKGAY) said it was too early to call the non-IO combo approach a trend. "But there are exciting data to be published," he said. "The two will be working together - it will not all be about IO-IO."

If one thing is certain, however, it is that data will come thick and fast, and this will affect the way deals are done. The important thing seems to be just to get deals signed to get the combos into the clinic, and generate data, as quickly as possible, said Mr. Herpin.

"Once you have data we can work through the [deal] complexity," he added.

Editor's Note: This article discusses one or more securities that do not trade on a major U.S. exchange. Please be aware of the risks associated with these stocks.

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Deciphering The Immunology Combo Avalanche - Seeking Alpha

Security Awareness: How to Make Your Weakest Link Part of Your Defense – Security Intelligence (blog)

While the origin of the recent WannaCry exploit is still under investigation, there is no doubt that humans remain the weakest link in the chain of defense against cyberattacks.

According to the IBM X-Force Threat Intelligence Index, human factors play a major role in various types of attacks. While its easy to blame users, many overlook the fact that these individuals can be turned into a valuable asset for an organizations defense capabilities. A well-aligned, orchestrated security awareness program can unlock this potential, but its success depends on practices beyond the typical security domain namely, psychology, communication and culture.

The traditional approach is to define an acceptable use policy and require users to sign it. This may help to transfer some responsibility to the users, but it does not make an organization more secure at the end of the day. Making users part of your defense requires more than a warning finger; its about changing behavior.

While the elements of a security awareness program depend on an organizations structure, business and culture, human behavior change is based on fundamental principles. The first tenet urges security leaders to include users in the mission instead of treating them as a risk. To be part of the mission, individuals need to understand it, recognize risky situations and react in a proper manner.

Furthermore, successful awareness programs involve other such as human resources, legal, marketing and physical security that often have mutual interests. These departments can collaborate to make security awareness efforts mandatory and contribute valuable resources such as funding and distribution tools. Human resources can build security awareness into onboarding and performance management processes, for example.

Human factors contribute in many ways to security risks, from dealing with phishing emails to handling sensitive data and interacting with other company assets. It is simply impossible to address all these issues at once. Instead, security leaders should focus on the most severe behaviors from a risk management perspective.

This approach will help to keep messages clear and prevent users from viewing security as an annoyance. Users are confronted with many daily obligations and simply dont have time to wait for another set of tasks. Therefore, you should split your messages into small portions, assign tasks that take no longer than 15 minutes and distribute the content over a period of time. This approach also makes it easier to keep software up to date.

People consume information in different ways depending on their background, profession and generation. Successful programs incorporate a variety of channels to make the message stick, including newsletters, posters, games, news feeds, blogs, simulated phishing attacks and more. In general, the most participatory efforts appear to have the most success.

If you invest time and money to strengthen your security program, you should be able to report its effectiveness to management and stakeholders. The only way to do this is to collect metrics in advance of awareness efforts. Without this baseline, it is hard to demonstrate success.

Security awareness metrics can include surveys to gauge attitudes and more statistical values such as results from simulated phishing attacks before and after awareness training. It might also be helpful to examine the number of security-related incidents. Measurable improvements, in any aspect of security, will help justify the program and, eventually, obtain additional funding and support.

Watch the On-Demand Webinar: Orchestrate Your Security Defenses

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Security Awareness: How to Make Your Weakest Link Part of Your Defense - Security Intelligence (blog)

What legalization would mean for wages, and the anatomy of a banda. – Monterey County Weekly

Dear Mexican: Im reading the redneck rhetoric in your most recent column, and I feel retarded to continually be surprised by the hate guised as nationalism that so easily flows from mouths of these degenerates. At least we don't have to worry about that nice stereotype like the Canadians.

Isn't it possible that no one wants to make taxpayers out of all of the illegals because this would entitle them to minimum wage? I agree that if you're going to enjoy the benefits of this country, you should maintain your culture, but also become a legal American citizen. But can we afford to actually pay full price for the labor foundation that we currently enjoy at such a discount?

-Dr. W

Dear Gabacho: Interesting punto! Gabachos dont want undocumented Mexicans to become American citizens because theyre Mexicans, and they really feel that once we become the majority, well rip out their hearts, wrap them in bacon, and serve them as a breakfast burrito.

And they also want us to remain perpetual peons, even if making us legal brings more money to the American economy. A 2013 paper by the Center for American Progress found that if undocumented immigrants were granted legal status and the possibility of citizenship that year, the United States' gross domestic product would grow by an additional $1.4 trillion cumulatively over the 10 years between 2013 and 2022.

Not only that, but analysts Robert Lynch and Patrick Oakford forecast the creation of 203,000 jobs per year in that time frame with amnesty. On the other hand, if said undocumenteds only got legal status in 2013 but weren't eligible for citizenship for a decade, the GDP would grow by a relatively modest $832 billion.

Thats more of an economic stimulus package than Trump could ever possibly conjure upbut since gabachos hate truth nowadays, the prospect of amnesty long ago went the way of the Paris climate accords.

I've been to a number of Mexican-sponsored events that include the typical banda, those bands with 40 members and every instrument known to man. My question is, why do those grupos bring such enormous speakers?

For a party taking place in a backyard or a room that fits no more than 50, theyll bring speakers large enough for a stadium. And since were on the subject of bandas, why do they have so many friggin people in them anyway?

-Split Eardrums, but Happy

Dear Gabacho: The more speakers any Mexican band use, the angrier gabachos will get. This isnt rocket science, pendejo.

Why is it that if you call anybody from Latin America thats not from Mexico a Mexican, they get mad? But everybody from Latin America calls any white person a gringo, no matter if they are Canadian, English, German, French, etc. It seems to me that Latin Americans want to be called by their country of origin but don't give a crap about a white person's country of origin. Would this be racism or prejudice?

-Gringo Greg

Dear Gabacho: Because a gringo is technically a white foreigner regardless of country. Besides, spare me: You gabachos call us illegals even if our families have lived in Aztln since your ancestors were dying of the Black Death.

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What legalization would mean for wages, and the anatomy of a banda. - Monterey County Weekly

Anti-affirmations, when needed – Dothan Eagle

Believe it or not, I work really hard at self-regulation. I realize that sometimes I people at less than an optimal level, so I have a list of daily reminders I use to keep it between the ditches of acceptable human behavior.

Each day, I go through a checklist of dozens of behaviors I should not engage in, some learned by trial and error, others by observational guess work. Some of these include:

It is not okay to offer to bat clean-up if a couple who you are friends with tells you about their struggles with infertility.

When you see couples getting wedding photos shot at Wadlington Park or Porter Park, it is not okay to shout things like, Pull them bangs down, youve got a five-head going on, Put a little tongue in that kiss, its classy! or Olympus? Real photogs shoot Canon.

It is not okay to put on a button-down shirt and a pair of khakis, go to a restaurant, and pretend to be the manager, walking from table to table asking guests about their meals and saying Well, thats servers fired! if they complain about anything.

It is not okay to greet your elders at the gym by saying, What up, Centrum Silver? They are all in better shape than you and could break you like fettuccine.

It is not okay to say, Sucker, you could totally get a new cat for $50 when someone tells you about spending hundreds on a vet bill.

When you see old acquaintances posting wedding anniversary photos online, it is not okay to comment, Jeez, if I knew your standards were that low, I would have asked you out.

When the movie theatre plays the turn off your cellphones and devices message before the film, it is not okay to jump to your feet and point to the other audience members and shout, That means you!

When someone compliments you on being a good listener, its not okay to say, Its because Im not really paying attention.

Carelessness is not an acceptable answer if a child asks you where babies come from.

While helpful, it is not socially acceptable to announce Youve got 10 seconds to get out of here, after that I make no promises, upon walking into a stall in the mens room.

Were all a little crazy. Its just how you manage it thats important.

Suggestions for further corrections to Jim Cooks behavior may be relayed to jcook@dothaneagle.com, where they will be given thoughtful consideration.

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Anti-affirmations, when needed - Dothan Eagle

‘Grey’s Anatomy’ Season 14 spoilers: Meredith, Nathan together again? – Blasting News

Fans are hoping to see Meredith and Nathan together again in the upcoming Season 14 of "#Grey's Anatomy." So, what should the fans expect in the new season of the hit ABC drama?

According to new reports, Meredith (Ellen Pompeo) and Nathan (Martin Henderson) might be able to continue their relationship in "Grey's Anatomy" Season 14. Their relationship could finally get through the struggles that fans saw in the ending of GA Season 13.

There is no doubt that "Grey's Anatomy" Season 13 left a lot of cliffhangers in the story. Speculations are making the rounds that Meredith and Nathan might finally rekindle their romance in the upcoming GA Season 14.

Meredith and Nathan's relationship was affected by the return of Megan. In Season 13 of the show, Megan, Owen's sister, and Nathan's fiance were found to be alive after disappearing for several years. People thought she had already died, but the lives and relationship of Nathan and Meredith will change now that she is back. Although Meredith and Nathan's romance was just getting started, it seems like it has already ended now that Megan is back.

During the Season 13 finale of the show, Meredith was the one who broke the news to Nathan. She told hem that Megan is actually alive and urged him to visit her. Meredith even told Nathan that she would have rushed to Derek if she knew he was alive. It seems like Meredith is willing to give up Nathan just to see him happy. However, fans are worried about the future and happiness of Meredith.

It was clear that Meredith was actually ready to introduce Nathan to her kids as her boyfriend. She was even ready to let her friends know that he and she are already dating. However, Megan's return has affected their new relationship.

Rumors are now making the rounds that Megan's traumatic experience might cause her to refuse to go with Nathan. If this happens, then Nathan can finally move on with Meredith. Fans are hoping to see the two continue their relationship in GA Season 14.

Reports claimed that the fans are tired of seeing Meredith unhappy, which is why they are hoping to see her end up with Nathan in GA Season 14. Hopefully, the producers of the show can hear the fans out.

"Grey's Anatomy" Season 14 comes back on small screens in the fall and will air every Thursdays at 8/7c on ABC. #Grey's Anatomy Season 14 #Grey's Anatomy meredith

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'Grey's Anatomy' Season 14 spoilers: Meredith, Nathan together again? - Blasting News

Diagnostic Services – JFK Medical Center

Types of Neurological Disorders

The Neuroscience Institute specializes in the diagnosis and treatment of:

Causes of Neurological Disorders

People of all ages are at risk for neurological problems. Some common causes include:

The NJ Neuroscience Institute offers advanced diagnostic resources to assist physicians in the accurate and timely assessment of neurologic disorders. This includes a comprehensive collection of monitoring devices, which are available on an outpatient, inpatient and intraoperative basis.

Advanced diagnostic techniques rely on a combination of tests and a careful historical understanding of the problem. Tests available at the Institute include:

The specialists at the NJ Neuroscience Institute take a multidisciplinary team approach, relying on open communication, to ensure a unique treatment program for each patient. These disciplines include:

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Diagnostic Services - JFK Medical Center

A Periodic Table of Behavior for Psychology – Psychology Today (blog)

Modern science took off during the Enlightenment and changed the world. Science was differedfrom philosophy in that it did not presuppose how nature must be, as the early philosophers tended to do, but instead scientists got up out of their armchairs and asked questionsand gathered data about howuniverse actually behaved.Observation, measurement and experimentation became the sine qua non of the scientific enterprise, and this has continued into the present day.

Science has been so successful that philosophy has drifted into the background, so much so that some scientists (e.g., E. O. Wilson) have wondered if philosophy is even necessary. This love of empiricism was soaked up by scientific psychologists. In his popular Psych 101 text, David Myers states that the key word in psychologys definition is science and that psychology is less a set of findings than a way of asking and answering questions,meaning that psychologists approach their subject matter through the lens and methods of empirical science.

What is the problem with this?The problemthat emerges is thatthere is no general framework for understanding the concepts and categories under investigation. Consider physics. Prior to Newton, physics was a pre-paradigmatic mess, meaning that the concepts and categories that physicists were using were highly inconsistent. One of the great achievements of Newtonian science was the emergence of a shared definitional system that could be examined empirically. Notice the first part of this sentence. A shared definitional system. That is a key aspect of cumulative science. And it is something physics, chemistry and biology largely have achieved, at least at the core of the discipline. That is, they know generally what matter, energy, electrons, neutrons, genes, cells, evolution and so forth "mean".And is one of the decisive factors that makes themworthy of the name"science".

Psychology completelylacks a shared definitional system. There is NO agreement on terms like behavior, mind, cognition, self, consciousness, and the like. And, with its focus on empiricism, psychology will not achieve such an understanding because observation and experiment alone are not enough to define these terms. What is needed is a holistic map that allows investigators to consider the concepts and categories that are used for understanding.

The concepts and categories that one uses to map reality is ones metaphysical system. The Periodic Table of the Elements is a metaphysical system. It offers a map of the elements, lining them up into different categories. It is a map that is supported by empirical work, but the map itself is metaphysical in nature.

Psychology needs a metaphysical system for understanding as much as it needs empirical research. Without advances in achieving a shared metaphysical system, psychology will continue to exist as a collection of studies that offer interesting glimpses into the human condition, but not deep understanding.

The Tree of Knowledge System offers the field of psychology (and science in general) a metaphysical system from which to operate. Specifically, it offers a clear: (a) cosmology; (b) ontological map of key categories in nature; and (c) epistemological framework for knowledge acquisition.

In terms of cosmology, the ToK System offers a Big History view of the Universe. Consistent with empirical work on the early universe, the ToK System posits that we can understand the universe as an EnergyMatterSpaceTime grid that emerged from a (pure energy) singularity at the Big Bang, approximately 13.8 billion years ago.

In terms of ontology, in the ToK System, Energy is the ultimate substance common denominator. The observable universe is "Energy" in all its different forms (Matter is chunked, frozen energy).The ToK further posits that universe evolves as an unfolding wave of Energy-Information, which, consistent with the Big History formulation, can be placed on the dimensions of time and complexity.

Furthermore, the ToK System posits a general behavioral metaphysics. That is, the ontological essence of the universe can be well-described as change in object-field relationships over time (also characterized as the flow of Energy-Information).

Because the ToK posits the essence of the universe exists as an unfolding wave of Energy-Information, the ToK gives rise to a novel view of primary categories in nature. Specifically, it argues that there are four identifiable dimensions of complexity, which are depicted and labeled Matter, Life, Mind and Culture. These dimensions capture the behavior of 1) objects; 2)organisms; 3)animals and 4)humans. It proposes that these core categories are differentiated because each category behaves in a fundamentally novel way. That is, living objects behave qualitatively differently than inanimate objects. Animal objects behave qualitatively differently than other kinds of organisms. And human objects behave differently than other animals.

According to the ToK, these fundamental divisions exist because of the evolution of different systems of information processing. The storage and processing of information on the DNA molecule gives rise to fundamentally different kinds and levels of self-organization, such that the workings of a cell are qualitatively different than the behavior of organic molecules (and are represented as existing on a separate dimension of self-organization and require a different science, biology, to describe explain and predict).

The emergence of a nervous system in general and brain in particular gave rise to another information processing system that resulted in animal behavior and experiential consciousness, which are qualitatively different behavior patterns than are seen at the level of the cell or molecule. The Mind, Brain, and Behavior sciences (behavioral neuroscience, computational/cognitive neuroscience, comparative psychology, ethology, etc) describe this specificdimension of behavior. The ToK System characterizes these class of sciences basic psychology, although it should be acknowledged that, given the fields institutional history, perhaps this cluster should perhaps just be labeled thesciences ofMind, Brain, and Behavior.

Last, the emergence of language connected human minds together in novel way, giving rise to human culture and societal group organizations that are fundamentally different than is seen in the rest of the animal kingdom.

The general behavioral metaphysics of ToK System gives rise to a Period Table of Behavior, depicted here. A novel feature of the ToK categorization system of these concepts is that it positsthat nature must be divided into both levels (part, whole, group) AND dimensions of complexity (Matter/Objects, Life/Organisms, Mind/Animals, and Culture/Humans).

In terms of epistemology, the ToK System is both empirical and metaphysical, meaning that it emphasizes knowledge acquired through the senses and experiment and emphasizes the need to place such datainto a coherent conceptual framework. It is the union of empirical data with coherent conceptual mapping that provides the most justified knowledge. This can be referred to as a Metaphysical Empirical epistemological position.

The ToK System is consistent with modern physics, chemistry, and biology. It is particularly useful at the level of psychology because it provides a new way to define behavior in general. Behavior is the unfolding wave of Energy-Information. Thus, Matter and Life behave. Psychologists have been horribly confused about this point. The ToK makes the common sense pointthat psychologists are interested in a particular kind of behavior, specifically mental behaviors, which are represented by the third dimension of complexity on the ToK System.Mental behaviorsare the behaviors of the animal as a whole, mediated by the nervous system.In such a formulation, the mind refers to the functional information stored and processed by the nervous system. It is largely synonymous with the broad definition of cognition. Here is a map of the information processing architecture of the human mind.

In the ToK System, experiential consciousness is conceptualized as an embodied whole brain activity that gives rise to experiential awareness, and is well defined and studied empirically by frameworks such as global neuronal workspace theory.

Humans exhibit mental behavior like other animals, but there is an added dimension of complexity. Human language connected human minds, much like the internet connects individual computers (and much like the nervous system connected organ systems in a centralized control center). This results in a qualitative jump in behavioral complexity. Language, along with other technological developments like agriculture, historically set the stage for massive societal/cultural evolutionary changes. As society became more and more complex, large scale belief/justification systems emerged, such as religion, law, and science. Such systems are denoted as Culture with a capital C.

Human self-consciousness is a second order form of consciousness in which the experiential conscious system is reflected upon and narrated, either to ones self (private self-consciousness) or to others (public self-consciousness). The human self-consciousness system functions to build justification systems for ones actions in society. Thus, there are three key domains to human consciousness. An experiential theater of first person awareness, an I-Me second order private self-consciousness system and an I-Thou public self-consciousness system. Here is a map of human consciousness.

Psychologistsstronglyaspire fortheir discipline to be a "real" science. However, to accomplish this dream, psychologists need to realize that empiricism per se is not sufficient. If each researcher continues to operationalize the mind, behavior, cognition, consciousness, or whatever phenomena of interest they are investigating via their own (metaphysical) system of understanding, then, despite the best experiments, all we will have is conceptual mush because there will be no way to relate the findings systematically. The ultimate goal of the field is not to just conduct experiments. It is to build a system of cumulative knowledge about human mental behavior. This is why we need something akin to a Periodic Table of the Elements. The ToK offers the field a Periodic Table of Behavior.

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A Periodic Table of Behavior for Psychology - Psychology Today (blog)

Ancient Mummies Finally Give Up Their Genetic Secrets – Smithsonian

The sarcophagus of Tadja, one of the mummies from Abusir el Meleq that had its DNA analyzed in a new study.

Historically, the idea of extracting DNA from an Egyptian mummy has been a bit like trying to suck dinosaur DNA out an insect trapped in amber: a tantalizing prospect, but still more myth than science. "This has been around for a long time as a hot topic," says Johannes Krause, a geneticist at Germany's Max Planck Institute for Evolutionary Anthropology. But unlike the dino scenario, it turns out analyzing mummy DNA is actually scientifically possible.

Krause has spent his career teasing information out of very old DNA. His work has led to the discovery of a new subspecies of human, which he helped identify from a bone fragment in a European cave; he also definitively identified the disease behind the infamous Black Death by examining dug-up plague victims. Now he can add another ancient jewel to his list: mummies. His team has managed to extract the first intact DNA from thousands-year-old Egyptian mummies, allowing them to unravel the secrets of their genetic heritage.

The discovery comes out of a relatively new field known as archaeogenetics. It was founded by a Swedish biologist named Svante Pbo who claimed to have extracted the DNA of 23 ancient Egyptian mummies as a young researcher in the 1980s. However, Pbo's work fell under heavy criticism from other scientists when it became clear that his DNA samples could be contaminated with modern DNA, Krause says. By the 2000s, some experts had begun to question whether it was even possible to extract usable DNA from mummies that had been weathered for so long by the hot, dry Egyptian climate.

Advances in DNA sequencing technology in the past eight years, particularly "high-throughput" sequencing technologythat can sequence millions of DNA base pairs quickly, cheaply and accurately, have reopened the possibility that Egyptian mummies could give up their genetic secrets, Krause says. Last year, he and his colleagues aimed to learn more about the genetic makeup of ancient Egyptian peopleand particularly, how their population had been influenced by a particularly turbulent, thousand-year chapter of history.

Starting in the 8th century BCE, waves of migration and conquest from Rome and farther south in Africa shook the region. If they were indeed able to extract mummy DNA, Krause expected to find the effects of this period of invasionand, presumably, intermixingwritten in the genetics.

Drawing on two mummy collections from German universities, the team analyzed more than 150 mummies recovered from an ancient area of middle Egypt called Abusir el-Meleq, a thriving city along the Nile River where many Egyptians were buried starting in 1500 BCE. The mummies ranged in age from 2,000 to 3,000 years old. These were not pharaohs or wealthy Egyptians buried in elaborate stone sarcophagi, Krause says, but rather ordinary, "middle-class" people buried in simple painted wood coffins. "At the time, they mummified almost everything," Krause says, including pets and wild animals.

Using these new techniques, Krause was able to find complete mitochondrial genomes in the tissues of 90 of those mummies, according to a study published yesterday in the journal Nature Communications. While previous studies of ancient mummy DNA tended to focus on sampling from the remaining soft tissues of the bodies (i.e. muscle, skin and organs), Krause says his team found that actually the bones and teeth of the mummies best preserved the people's DNA, because these structures were less exposed to the heat and humidity that can degrade genetic material.

To rule out the contamination that sank previous studies, Krause relied on work of geneticists in the last decade who have learned how to track the damage that occurs to the structure of DNA as it degrades over hundreds or thousands of years. Newer, undamaged DNA that had contaminated a sample would now stand out in an analysis of older, pockmarked DNA. "With these DNA damage patterns, we're really able to authenticate ancient DNA," Krause says.

So how did the genetic makeup of the people living Abusir el-Meleq change in these turbulent centuries?

"Nothing really happened. It was very boring," Krause says with a laugh. Apparently, all that conquering didnt significantly change the genetics of this Egyptian populationwhich, in itself, was unexpected. That was actually a bit of a surprise to us, Krause says.

Next, Krause wanted to compare what he found in the ancient DNA to the genetics of modern Egyptians, drawing on a genetic survey in 2015 that looked at human migration out of Africa. Predominantly, the modern people sampled appeared to share the most genetic ties with people today living in the Arabic countries of the Middle East. This contrasts with modern Egyptians, Krause says, who now appear to have more genetic origins from sub-Saharan Africa.

This suggests that the invading peoples from Nubia and Rome didnt significantly intermix with the ancient Egyptians during the centuries before the year 0 ADbut that sometime since, a mass influx of African genes entered the Egyptian population.

American University in Cairo egyptologist Salima Ikram found Krause's work overall to be "well-balanced, well-researched, and well thought-out." However, Ikram, who was not involved in the study, is skeptical about how definitive Krause's comparison to modern Egyptians really is. The genetic survey of modern Egyptians cited by Krause does not specify where the people sampled were from, Ikram says, a data gap that could have big implications on the conclusion.

"Despite mobility, [there] are [still] pockets of ethnic groupings," Ikram says. Samples from southern Egypt or slave-trade centers could therefore show much more sub-Saharan African influence than samples from northern port cities that could have more European influence from the Crusades.

In future studies, Krause hopes to collect more mummy DNA from around Egypt to pinpoint when and why ancient Egyptians began to change geneticallyand to find out exactly how their ancestors migrated to the fertile crescent in the first place. "What we're most interested is extending the data back in time," he says.

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Why ‘Grey’s Anatomy’ Jaggie Is the Worst Idea Ever – BuddyTV (blog)

The Grey's Anatomy Season 13 finale introduced us to the world of Jaggie. Apparently this had been teased for a while, but honestly I never saw it. For those who aren't quite sure about shipper names, Jaggie is Jackson and Maggie, who are step-siblings through their parents' (Catherine and Richard) marriage. It's been two weeks since the Grey's Anatomy season finale and fans are still discussing the idea, with the majority agreeing that this is the worst relationship Shonda Rhimes and her writers have ever come up with. I, for one, fully agree with these fans. Jaggie is the worst idea ever for Grey's. The Relationship Came out of Nowhere

I know a lot of fans discussed the idea of Jaggie happening weeks before the season finale. I remember soon after Maggie's mom died and fans said there were hints that they were getting together in those moments of the two together.

Now, fans do have a habit of seeing things that aren't always there. This is the beauty of TV. It's possible to pick up on sly looks or the way someone says a line but have completely different opinions about what the characters actually meant. That scene of Jackson sharing the photos he'd found of Diane with Maggie never looked like a hint of a relationship to me. It looked like a hint of friendship, something that both characters have needed for a very long time.

When April told Maggie that Jackson liked her in the season finale, it felt rushed and unnecessary. The whole idea of Jaggie came out of the blue -- even Maggie didn't realize Jackson had feelings for her.

Jackson and April Had Just Reconnected

Grey's Anatomy fans had been waiting for Japril to happen again for a long time. There have been hints for months that they would find their way back to each other, and then in Montana it finally happened. Jackson and April fans danced around with glee at the idea of this couple finally rekindling their romance.

It's clear that April still has feelings for her ex-husband and vice versa. April is still living with Jackson as they raise their baby together. Bringing Maggie into the mix just complicates matters.

Sure, this can mimic real life, but this just doesn't sit right. There was a big thing about April and Jackson rekindling their relationship and then the idea was just abandoned. April is brushed to one side, as if she never even meant anything to Jackson at all. There Are Too Many Characters to Develop This Relationship

Grey's Anatomy took a lot on in season 13. We saw the relationship between Meredith and Riggs develop (with the problem of Maggie liking Riggs.) Fans had to deal with the Minnick/Webber drama, while trying to support the idea of Arizona finding love with the unlikeable Minnick. On top of that we had the Alex court case problem, mixed with Stephanie being written out of the show.

There is something about Grey's Anatomyseason 13 that just didn't work. There were far too many storylines over the space of 24 episodes, leaving some unfulfilling moments, abandoned/forgotten storylines and difficult-to-follow moments.

Bringing in another couple just doesn't work. Season 14 is already going to have multiple storylines to run. Megan is back, causing all types of drama for Owen and Riggs. Amelia and Owen are still getting through their rough patch, and Bailey needs to reverse the mess she caused by hiring Minnick. There just isn't room for a new (out of the blue) relationship to be introduced.

To top this off, fans just don't want it. They want to see Jackson and April together. Fans want to see the two raise their daughter together.

Do you think Grey's Anatomy's Jaggie will work? What were your thoughts in the first moment you found out Jackson really does have feelings for Maggie? Share your thoughts in the comments below.

Grey's Anatomyseason 14 returns in the fall on Thursdays at 8/7c on ABC. Don't forget to like our Grey's AnatomyFacebook page to get the latest updates and articles straight to your newsfeed.

(Image courtesy of ABC)

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Why 'Grey's Anatomy' Jaggie Is the Worst Idea Ever - BuddyTV (blog)