All posts by medical

The anatomy of a capsize: how did a multi-million dollar America’s Cup boat end up in the drink? – Telegraph.co.uk

'The bear away'

Both teams are now having to make what is known as a 'bear away' in order to cross the start line within the designated boundaries. Because you can't sail a boat directly into the wind, you have to tack or gybe, essentially zig-zagging your way from A to B. As you execute each turn you must bear away from the direction that the wind is coming from, but this can be destabilising if you try to make too sharp or too hasty a turn.

As you can make out from the second freeze-frame, New Zealand have been forced a little wider and are closer to the start line when they begin to bear away. That means the angle on their turn is significantly more acute.

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The anatomy of a capsize: how did a multi-million dollar America's Cup boat end up in the drink? - Telegraph.co.uk

Warren Alpert Foundation Honors Five Pioneers in Cancer Immunology – Harvard Medical School (registration)

The 2017Warren Alpert Foundation Prizehas been awarded to five scientists for transformative discoveries in the field of cancer immunology.

Collectively, their work has elucidated foundational mechanisms in cancers ability to evade immune recognition and, in doing so, has profoundly altered the understanding of disease development and treatment. Their discoveries have led to the development of effective immune therapies for several types of cancer.

The 2017 award recipients are:

The honorees will share a $500,000 prize and will be recognized at a day-long symposium on Oct. 5 at Harvard Medical School.

The Warren Alpert Foundation, in association with Harvard Medical School, honors trailblazing scientists whose work has led to the understanding, prevention, treatment or cure of human disease. The award recognizes seminal discoveries that hold the promise to change our understanding of disease or our ability to treat it.

The discoveries honored by the Warren Alpert Foundation over the years are remarkable in their scope and potential, said George Q. Daley, dean of Harvard Medical School. The work of this years recipients is nothing short of breathtaking in its profoundimpacton medicine. These discoveries have reshaped our understanding of the bodys response to cancer and propelled our ability to treat several forms of this recalcitrant disease.

The Warren Alpert Foundation Prize is given internationally. To date, the foundation has awarded nearly $4 million to 59 scientists. Since the awards inception, eight honorees have also received a Nobel Prize.

Wecommend these five scientists.Allison, Chen, Freeman,Honjoand Sharpe are indisputable standouts in the field ofcancer immunology, said Bevin Kaplan, director of the Warren Alpert Foundation. Collectively,they are helping to turn the tide in the global fight against cancer. We couldn'thonor more worthy recipients for the Warren Alpert Foundation Prize.

The 2017 award: Unraveling the mysterious interplay between cancer and immunity

Understanding how tumor cells sabotage the bodys immune defenses stems from the collective work of many scientists over many years and across multiple institutions.

Each of the five honorees identified key pieces of the puzzle.

The notion that cancer and immunity are closely connected and that a persons immune defenses can be turned against cancer is at least a century old. However, the definitive proof and demonstration of the steps in this process were outlined through findings made by the five 2017 Warren Alpert prize recipients.

Under normal conditions, so-called checkpoint inhibitor molecules rein in the immune system to ensure that it does not attack the bodys own cells, tissues and organs. Building on each others work, the five award recipients demonstrated how this normal self-defense mechanism can be hijacked by tumors as a way to evade immune surveillance and dodge an attack. Subverting this mechanism allows cancer cells to survive and thrive.

A foundational discovery made in the 1980s elucidated the role of a molecule on the surface of T cells, the bodys elite assassins trained to seek, spot and destroy invaders.

A protein called CTLA-4 emerged as a key regulator of T cell behaviorone that signals to T cells the need to retreat from an attack. Experiments in mice lacking CTLA-4 and use of CTLA-4 antibodies demonstrated that absence of CTLA-4 or blocking its activity could lead to T cell activation and tumor destruction.

Subsequent work identified a different protein on the surface of T cellsPD-1as another key regulator of T cell response. Mice lacking this protein developed an autoimmune disease as a result of aberrant T cell activity and over-inflammation.

Later on, scientists identified a molecule, B7-H1, subsequently renamed PD-L1, which binds to PD-1, clicking like a key in a lock. This was followed by the discovery of a second partner for PD-1the molecule PD-L2which also appeared to tame T-cell activity by binding to PD-1.

The identification of these molecules led to a set of studies showing that their presence on human and mouse tumors rendered the tumors resistant to immune eradication.

A series of experiments further elucidated just how tumors exploit the interaction between PD-1 and PD-L1 to survive. Specifically, some tumor cells appeared to express PD-L1, essentially wrapping themselves in it to avoid immune recognition and destruction.

Additional work demonstrated that using antibodies to block this interaction disarmed the tumors, rendering them vulnerable to immune destruction.

Collectively, the five scientists findings laid the foundation for antibody-based therapies that modulate the function of these molecules as a way to unleash the immune system against cancer cells.

Antibody therapy that targets CTLA-4 is currently approved by the FDA for the treatment of melanoma. PD-1/PD-L1 inhibitors have already shown efficacy in a broad range of cancers and have been approved by the FDA for the treatment of melanoma; kidney; lung; head and neck cancer; bladder cancer; some forms of colorectal cancer; Hodgkin lymphoma and Merkel cell carcinoma.

In their own words

"I am humbled to be included among the illustrious scientists who have been honored by the Warren Alpert Foundation for their contributions to the treatment and cure of human disease in its 30+ year history.It is also recognition of the many investigators who have labored for decades to realize the promise of the immune system in treating cancer. -James Allison

The award is a great honor and a wonderful recognition of our work. -LiepingChen

I am thrilled to have made a difference in the lives of cancer patients and to be recognized by fellow scientists for my part in the discovery of the PD-1/PD-L1 and PD-L2 pathway and its role in tumor immune evasion. I am deeply honored to be a recipient of the Alpert Award and to be recognized for my part in the work that has led to effective cancer immunotherapy. The success of immunotherapy has unleashed the energies of a multitude of scientists to further advance this novel strategy. -Gordon Freeman

Iam extremely honored to receive the Warren Alpert Foundation Prize.I am very happy that our discovery of PD-1 in 1992 and subsequent 10-year basic research on PD-1 led to its clinical application as a novel cancer immunotherapy. I hope this development will encourage many scientists working in the basic biomedical field. -TasukuHonjo

I am truly honored to be a recipient of the Alpert Award. It is especially meaningful to be recognized by my colleagues for discoveries that helped define the biology of the CTLA-4 and PD-1 pathways. The clinical translation of our fundamental understanding of these pathways illustrates the value of basic science research, and I hope this inspires other scientists. -Arlene Sharpe

Previous winners

Last years awardwent to five scientists who were instrumental in the discovery and development of the CRISPR bacterial defense mechanism as a tool for gene editing. They wereRodolpheBarrangouof North Carolina State University,Philippe Horvathof DuPont inDang-Saint-Romain, France,JenniferDoudnaof the University of California, Berkeley,EmmanuelleCharpentierof the Max Planck Institute for Infection Biology in Berlin andUmeUniversity in Sweden, andVirginijusSiksnysof the Institute of Biotechnology at Vilnius University in Lithuania.

Other past recipients include:

The Warren Alpert Foundation

Each year theWarren Alpert Foundationreceives between 30 and 50 nominations from scientific leaders worldwide. Prize recipients are selected by the foundations scientific advisory board, which is composed of distinguished biomedical scientists and chaired by the dean of Harvard Medical School.

Warren Alpert (1920-2007), a native of Chelsea, Mass., established the prize in 1987 after reading about the development of a vaccine for hepatitis B. Alpert decided on the spot that he would like to reward such breakthroughs, so he picked up the phone and told the vaccines creator, Kenneth Murray of the University of Edinburgh, that he had won a prize. Alpert then set about creating the foundation.

To award subsequent prizes, Alpert asked DanielTosteson(1925-2009), then dean of Harvard Medical School, to convene a panel of experts to identify scientists from around the world whose research has had a direct impact on the treatment of disease.

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Warren Alpert Foundation Honors Five Pioneers in Cancer Immunology - Harvard Medical School (registration)

‘Shakespeare in the Really Disturbing, Chaotic Park’ – VICE

This story originally appeared in GARAGE Magazine No. 11. GARAGE's life-changing, mind-altering launch is coming soon. Until then, we're publishing some of our old favorites, plus a few original stories, essays, videos, and more to give you a taste of what's to come.

Ian Cheng was born in 1984 in Los Angeles. Now based in New York City, he creates virtual ecosystems he calls "simulations." The simulations are unscripted: they function like video games that play themselves, and Cheng doesn't know exactly how they will turn out. Each is an examination of the dynamics of human behavior, an interrogation of narrative, and an exploration of rationality and motive.

After shows at the Migros Museum in Zrich, the Smithsonian's Hirschhorn in Washington, D.C., Pilar Corrias in London, and an installation in the Whitney Museum's recent exhibition Dreamlands: Immersive Cinema and Art, 1905-2016, Cheng currently has on view his first U.S. museum solo presentation at MoMA PS1, entitled Emissaries, through September 25.

Exclusively for GARAGE, Cheng and Haley Mellin discuss the connection between mind and body, the effects of software on culture, and the tension between deterministic narrative and abysmal base reality.

(This introduction was revised to update the artist's exhibition history.)

Haley Mellin: I just played the digital commission you did for the Serpentine and loved it. What brought you to cognitive science? Ian Cheng: It was a gut feeling. I've always been interested in how human behavior is shaped. What is Mom thinking? What is Dad thinking? What is the cat thinking? What is their misunderstanding? What is my role between them? Things an only child thinks about. Cognitive science seemed to offer a tool set. At the time, at UC Berkeley, that was a combination of neuroscience, linguistics, computer science, and psychology, with an aim of developing a general understanding of cognition that could inform approaches to artificial intelligence.

HM: What was happening with artificial intelligence in the mid-2000s? IC: At the time, artificial intelligence was in the dark ages. Most research was based on a kind of objectivity fallacythe perspective that to make a computer intelligent you had to feed it a million factslike creating a Jeopardy champion. You soon realize that a computer with a million facts quickly exhausts itself. You ask it a question like, "What do you see?" It has no idea. The current paradigm of artificial intelligence is closer to nature. It begins from a position of subjective stupidityyou endow a computer with the ability to sense and develop patterns from its senses. Humans act as its trainer. Like the way a small child or dog learns. Once an AI can learn, regardless of what it learns, it can develop a subjective understanding of the world from the bottom up, rather than from the top down. It can have agency.

HM: What was it that brought you into working with moving digital images? IC: After Berkeley, I worked at Industrial Light & Magic, George Lucas's postproduction visual-effects studio. It was exciting, though, over time, I started to feel like one cog in a very, very big machine. There were hundreds of artisans and technicians working on Optimus Prime punching a skyscraper.

HM: The visual effects in those films are a fascinating force of collaboration. What happened after? IC: I then went to grad school at Columbia's MFA program. My peers were very talented and prolific. But I felt lost. I couldn't bring myself to do anything. I felt art isn't worth doing unless I can find some kind of leverage, some technology that could render the familiar into something alien. When you use a technology that has not been over-exhausted by other people, you have a stake in defining the language, the compositional principles, and a perspective toward that technology. I felt that I needed to do that, in order to feel like I wasn't just polishing territory that many other artists have explored already. I have a constant curiosity for technologies in the loosest sense, whether an actual tool or a soft thing, like a perspective. This leveraging has been an operating principle I have had as an artist since the beginning.

HM: I saw your work first in 2012, at West Street, the apartment gallery that Alex Gartenfeld and Matt Moravec created in New York. The piece was an animation on an iPhone, which I think was placed near a window, with the Hudson River beyond it. The figure in the video was stripped of detailjust essentialswhich came across to me as both primitive and advanced. IC: The video you're talking about is called This Papaya Tastes Perfect. It looks like an animation and it is animated, in fact, but it was done using motion capturea process in which you place markers on a real performer's body, so their movements can be translated onto a digital avatar. Three-dimensional animation has a reputation for being smooth, frictionless, plastic. But I wanted to see if something as artificial as 3D animation could capture human behavior that had the friction, or visceralness, that we find in life itself. This desire to get closer to nature and aliveness led to making what I call "simulations"I think of them as video games that play themselves. They are open-ended software systems that simulate an ecology. It's a form that can contain an ever-evolving relationship between agents and environment.

HM: Your earlier simulations were like chaotic systems. But the recent ones have an element of narrative in them. IC: I found myself thinking about how you and I are creatures of narrative. We eat and breathe narrative. I wanted to use narrativewhich I see as a deterministic, scripted forceto counterbalance the entropy and chaos in the simulations. I begin with open-ended ecosystems, which contain various agents with A.I.s that are very reactive to the environment. Then I introduce one agent who has a very different intelligence a set of narrative goals that it doggedly tries to achieve. It's like giving an actor a script and telling her she has to get through her lines no matter what obstacles get in her way. It's like Shakespeare in the Park, but it's a really disturbing, chaotic park, where everything's going wrong, but the agent still tries.

HM: I like that your content is unpretentious and direct. You're working with sculpting the soft material of human behavior. IC: I feel that having a narrative script, or having a life script, is an incredibly useful tool for orienting oneself, especially in times of uncertainty. It allows you at least to give yourself a direction, and a sense of place within the timeline of the imagined script. It is a self-made fiction, but it gives you courage. In two recent simulations, Emissary in the Squat of Gods and Emissary Forks at Perfection, I've started to program a character that has an orienting script in spite of all the chaos around him or her. What you see as a viewer is a battle between an open-ended ecological system that is amoralthere is no good or bad, things just happen as they do in natureand a highly scripted character who is trying to negotiate this world with a sense of purpose, with a sense of morality. The two forces sculpt each other.

HM: Are the digital materials you're using refined enough to communicate what you're intending, or is there work you want to make that you cannot? IC: I never fully arrive. I keep moving the goalposts. At the moment, I'm trying to figure out a model of intelligence that is located in the relationship between thingsthe idea of intelligence not located entirely in an organism's head, but instead distributed between the organism and the other objects in its environment. Like how the intelligence required to ride a bike is cued by the presence of the bike, but fades away when there is no bike available.

HM: To me, you are a documentarian of what is ahead. Your artwork gives me a feeling of being in a new body. IC: I've realized, in making these simulations, that having a body really matters. More and more, I can't imagine artificial intelligence without some kind of prosthetic body to ground itself in. The A.I. of a self-driving car needs the Umwelt of a car. I've had to find a level of representation that not only we as viewers can relate to, but that the simulated creatures need to achieve agency. That is something I am working on nowhow does the body morphology of a virtual creature influence the intelligence of the creature?

HM: It would be something if you could collaborate with an artificial-intelligence machine and have the artificial intelligence make the body of your character. It would be inventing something that it doesn't know, but inherently must be wired into. IC: I want to make art for children. I want to make work that is engaging to a five-year-old, and to do that, the work has to be alive. Children are the toughest critics.

HM: I played video games, such as Pong, Super Mario Bros., and World of Warcraft as a kid. Did you? IC: Yes. But now I play games to learn from them. In some ways I still feel like a child. Being an artist is like being the most adult-adult and being the most child-child. The reason we're talking now, at 11am, is because I need 7am to 10:59am to be a child. That's when my child brain is on and ideas flow like a tap. It's the opposite of that adult voice of doubt"This is an awful idea. You should be more worried. You haven't answered your email in 10 days." For me, that authority voice is completely absent in the morning, and I can dwell in a childlike state. I talk to myself without embarrassment. By noon, the other side of being an artist kicks in. I have to be more adult than someone with steady employment, because there's no boss. There's no scaffolding, no safety net. Nobody else has the burden of decision-making. It's a total head-trip, because no one tells you in art school that you have to become schizophrenic.

HM: I agree. We've talked about that before. I get emails from you at certain times of the day, not at all hours. I became patient for them. IC: I often want to give the authority to someone else, so they can make the decisions for me in moments of stress. Directors have producers. Start-ups have cofounders. But for artists and writers, no one cares about your work as much as you do. I work with a producer now, which has been a game changer for me.

HM: Sometimes I step back, time goes by, and it allows me to connect in a new way. Hesitation can be a tool. This brings me to think of the team working on the Microsoft HoloLens. It has taken them a long time to develop the technology, they have worked slowly, one foot in front of the other. It will combine digital holograms and reality into a new landscape. It will be like a more advanced state of what we play with Pokmon Go. IC: The best story I heard so far was that this fabulous pink Pokmon was sited inside the Westboro Baptist Church headquarters, and all these kids were rushing in, totally agnostic to the meaning of that place. Just eagerly trying to find the Pokmon inside. It's beautiful. It's a mainstream breakthrough of the idea that the social realities you live in are not strictly rooted in the physical world. A physical place is simply an address to hold multiple social realities, which are often mutually exclusive. It's a refactoring of the familiar by software. Pokmon Go is effectively a work of software in the same way that Uber is a work of software. It fundamentally re-factors the way in which material things are organized, their meaning, status, and value.

HM: Software has changed many of our basic actions. Look at Uber. IC: You couldn't trust getting in a stranger's car five years ago.

HM: Uber shows how an app can reprogram our motion. IC: I don't think a child would go into the Westboro Baptist Church if not for the overriding motivation of getting that amazing Pokmon. It transforms what's meaningful and what's meaningless. We get a clear feeling of the relativity of meaning through this compression of what's valuable and what's sacred versus what's vulgar and what's profane. We see now that software has this collapsing effect.

HM: So what if the battery on your phone dies and there's no amazing Pokmon? IC: You crash like Neo. Or like an Amish person visiting Times Square. You crash back into the shitty base reality that preceded your worldview.

HM: It makes me think of the Philip K. Dick quote you mentioned last year, "Reality is that which, when you stop believing in it, doesn't go away." I love that. It makes things clear and simple. If I stop believing in something, but it remains, then maybe it is real. Is the Pokmon digital character actually there? IC: It's there as much as, if you're a Christian, God is there. It's there in the sense that it organizes your life and is operative in how you act within the world. Whether it's physically real or not is irrelevant. Most of us, except for perhaps enlightened Buddhas, cannot withstand living in direct relationship to raw reality. Raw reality is meaningless and disorienting and almost impossible for any human to accept on a full-time basis. We need games to overlay onto raw reality to orient our lives, whether it's the game of Pokmon or the game of being a Christian or the game of college. Those games crash all the time, creating moments of social unrest and existential angst.

HM: Those are healthy moments, too, and we evolve into yet another game. IC: I've been reading a lot about Buddhism and Hinduism recently. Achieving enlightenment is actually very difficult, because when you're enlightened you're not in a more comfortable place. It's not like you get enlightened and then you're at peace because everything makes sense. Apparently, when you're enlightenedif you can ever be thatyou're actually in a much more abysmal, uncertain, and ambiguous place, but you're simply okay with that. You accept that abyss. This is radical. I think most humans can't withstand this. We're evolved to see faces in clouds. Find meaning. Make up a busy thing to do. There's a reason why monks and enlightened people are secluded in difficult-to-reach low-sensory places, high in the mountains, without too much complex human or ecological drama. It's a zone of minimum viable abyss.

HM: When the underlying structure of how you live and why and what you do breaks apart, finding a new orchestration can be slow, since you are building from the ground up. IC: It's often seen in our culture as a shameful process, like you fell off the wagon.

HM: Or a mental breakdown. IC: When someone falls off the script, there's a lot of shame attached to it, because everyone else in one's local ecology likes to feel secure in the script that's working for them. You can psychologically die in those momentsthat's when you become really depressedbut that's also where there's the most potential for clarity about where you are, and the most potential for reinvention.

HM: Oftentimes, things have to end for a new structure to begin, to start living from a new philosophy. When the system fails you, you create your own system. Often you've invested a lot of energy in a direction that you've taken seriously, and you can see how quickly the structures you relied on unravel. I learned recently how breaking things up is a kind of restructuring. IC: Yes. It forces a restructuring.

HM: There's a difference between what we conserve and what we change. I spend half my time working to preserve wilderness. IC: What parts of the world?

HM: Currently I'm working on an animal-migration corridor joining two national parks in Namibia. I have a different mind space when I'm in stretches of wildernessit's an area that has never had any sort of static structure or use imposed upon it. The body feels that it's not a national park, with all sorts of rules and boundaries. Animals are both very primitive and very advanced. They don't need all the objects and tools we use to live. IC: Yes.

HM: It's healthy for anyone who works in a creative capacity to spend time outside. My brain takes on an ease and rapidity of thought, because there is a lack of social structure. Things become black and whiteanything I am on the fence about becomes clear. IC: We've spoken about transforming things, and I think the things that need to be transformed are modelsculture, ingrained habits, our stories. On the flip side, the things that need to be preserved are the things that have no culture in them. Stretches of wilderness, where nature has built up so much embedded complexity and intelligence, even if it's inherently meaningless to us now. Later, we'll have all that richness and biologic history to learn from.

HM: I want to preserve a space without culture. Those spaces help us to understand what culture is. IC: It's an exercise in being in base reality.

HM: Now we're going in a different direction. IC: That's a good way to end, actually.

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'Shakespeare in the Really Disturbing, Chaotic Park' - VICE

Ethology and veterinary practice: Animal behavior and human perception – MultiBriefs Exclusive (blog)

In previous articles, I've mentioned that we can say nothing about what an animal's behavior means unless we know the context in which is occurs. In the case of companion animals, a key contextual element is the owners' and others' emotional perception of those animals.

However, when it comes to behaviors displayed by companion animals, it's not uncommon for human perceptions of the context to vary even within the same household. The same display from the family dog that one person considers loving, her partner may perceive as obnoxious, while their kids think it's funny. Meanwhile, their visiting relatives hate the dog because "she looks weird."

Those different human responses, in turn, may affect the animal's subsequent behavior in general or only with those specific individuals. Although multiple factors contribute to this mixed perceptual bag within the companion animal household, this month I'd like to consider one factor that practitioners also may experience directly or indirectly.

In a research paper entitled "Tail Docking and Ear Cropping Dogs: Public Awareness and Perception" published in PLOS ONE, Katelyn E. Mills, Jesse Robbins and Marina von Keyserlingk wanted to fill a gap in the literature regarding how surgical alteration of canine body parts affected human perception. Although previous studies explored the perceptions of veterinarians and breeders relative to these surgeries when performed for strictly cosmetic reasons, no one had addressed those of the public.

To provide insight into this segment of the population, the researchers conducted three experiments using American residents as subjects. Data for each experiment included the number of participants, mean age and range, sex and percentage of the total who functioned as the primary canine caregiver in the household.

In the first experiment, researchers showed each participant one professional photo of a dog belonging to one of four breeds in which tail docking and ear cropping commonly occurs: Doberman pinscher, miniature schnauzer, boxer or Brussels griffon. Participants then rated the dog using a list of 10 traits they considered of genetic or environmental origin using seven-point scale.

During the second part of this experiment, the participants received two photographs of the same breed of dog, one with surgically modified ears and tail and one without. The history accompanying these photos stated that the dogs were purebred siblings. Participants then had to choose one of three options to describe what the dogs' different appearances meant:

Although this may come as a surprise to some veterinarians, 42 percent of the 810 participants believed that the short ears and tail were of genetic origin in these breeds.

In the second experiment, the researchers explored if and how the appearance of natural and modified dogs influenced people's perception of the dog's temperament. To determine this, they had a professional artist restore the ears and tails on the photographs of the surgically modified dogs.

When completed, the researchers had two photos of each of the original four dogs: the original photo of the dog with cropped ears and docked tail, and one of the same dog with his or her natural ears and tail restored by the artist. They then asked participants to rate a collection of either all surgically modified or all (artificially restored) natural dog pictures using a canine personality questionnaire.

In general, participants perceived the modified dogs as more human- and canine-aggressive as well as "dominant." Those who received the natural dog photos perceived those animals as more playful and attractive.

Keep in mind that the experiment wasn't designed to determine whether any of these dogs truly possessed those qualities. It was designed to determine if and how cropped ears and docked tails could influence people's perception of dogs so modified.

The third experiment examined how others' perception of the people with these dogs changed depending on the absence of presence of canine ears or tails. In this case, identical full-body pictures of the same man or woman were paired with images of the surgically modified or natural Doberman.

Each participant received images of one man and a modified or natural dog and a second set of a woman paired with either a modified or natural dog. Subjects then had to answer questions regarding their perceptions of the supposed owner as well as the dog.

Given the differences in participants' perception of the modified and natural dogs, again it probably comes as little surprise that the participants' perceptions of the dogs' respective owners also differed. Traits assigned to the presumed owners of modified dogs included more aggressive, more narcissistic, less playful, less talkative and warm than the owners of natural dogs.

Additionally, participants perceived the female owner the of modified dog as more dominant, aggressive and competent than the female owner of the natural dog. Interestingly, the participants perceived the male owner of the modified dog as more narcissistic, less warm and less competent than that same man when paired with the natural version of the same dog.

But if these results will surprise few clinicians, why bother writing about them at all? Like all studies, this one has its flaws.

However, it does further support the notion that some people will make snap judgments of a dog's temperament and the person with the dog based solely on the dog's looks. And because dogs and their people routinely may congregate in veterinary practice waiting rooms, this may directly or indirectly affect how other clients interact with those animals and their people. And that, in turn, may affect the dog's behavior in the examination room as well as the waiting room.

Hopefully and regardless of their personal views, practitioners and their staff members know that cringing in response to every cropped-eared, docked-tailed dog that enters the veterinary clinic won't enhance the dog's behavior. And although it superficially might appear that more positive responses to naturally eared and tailed canines and their owners would be a win-win for everyone, that approach also can backfire.

Just as modified dogs and their owners may dwell anywhere on the spectrum of temperaments and personalities, so may natural dog-owner pairs. And some of these may be nicer and better behaved than others.

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Ethology and veterinary practice: Animal behavior and human perception - MultiBriefs Exclusive (blog)

Oxford Genetics gets 500000 from Mercia Technologies – Tech City News

BioTech firm Oxford Genetics has raised 500,000 from Mercia Technologies.

The news comes after the company, which specialises in synthetic biology and DNA design, raised 1m from Mercia, which has a direct equity stake of 47.9% in the firm in October last year.

Oxford Genetics has so far raised 5.8m through a combination of grants and external investments and says it will use this latest round to expand its reach in the US market and further its growth.

Oxfords AI firm Oxbotica gets 8.6m to lead driverless car consortium

Dr Ryan Cawood, CEO of Oxford Genetics, commented on the raise: Mercias continued support has been instrumental in helping us to achieve the significant progress to date.

Our turnover has doubled in the last year and with this additional capital, we will be able to further expand the team, giving us the ability to build the most innovative technologies in the DNA and protein design market.

Dr Mark Payton, CEO of Mercia Technologies PLC, spoke about the companys trajectory over the past year.

Oxford Genetics has clearly demonstrated its ability to create market leading technologies and has been bolstered by an industry leading research and development team.

Payton went on to note that life sciences and bio-sciences continued to be a key sector for Mercia and one which they believe would deliver significant shareholder value over the medium term.

Follow Yessi Bello Perez on Twitter @yessibelloperez

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Oxford Genetics gets 500000 from Mercia Technologies - Tech City News

New CEO for tilapia genetics firm – Fish Update

GENOMAR Genetics, which specialises in the tilapia industry, has appointed Alejandro Tola Alvarez as its CEO.

Alvarez (pictured), who took up his new role on June 1, will be responsible for innovation, operations and business development within the company, which is part of the EW Group.

He hasbeen part of the Genomar group since 2006, based in South-East Asia as chief operational officer and in Norway as chief technical officer.

We were very pleased to find a highly qualified internal candidate for the CEO position, said chairman Odd Magne Rdseth.

Alejandro has played a major role in both R&D and commercial development of the most reputable and professional genetic brands in global tilapia aquaculture.

He comes with a deep understanding of the tilapia operating environments and the opportunities of modern breeding technologies, such as genomics, to improve economic and environmental performance of the industry.

Alvarez is a qualified vet and has masters degrees in aquaculture and business administration.

GenoMar Genetics, based in Oslo with its main operation in Luzon, Philippines, has developed the Genomar Supreme Tilapia strain (GST) through more than 25 years of selective breeding.

The company was part of the Norway Fresh Group until March 2017 when EW Group concluded an agreement to acquire 100 per cent of GenoMar Genetics shares.

EW Group, based in Visbek, Germany, is a family owned holding company with more than 120 subsidiaries in over 30 countries.

The core business of the group, which has 9,000 employees worldwide, is animal breeding, animal nutrition and animal health.

Over the past 10 years, the group has expanded into the aquaculture sector and includes companies such as AquaGen, Aquabel, GenoMar Genetics and Vaxxinova.

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New CEO for tilapia genetics firm - Fish Update

Poplar Healthcare Acquires Genetics of Memphis – 360Dx (subscription)

NEW YORK (360Dx) Laboratory services firm Poplar Healthcare today announced it has completed its acquisition of cytogenetics reference lab Genetics of Memphis.

Financial and other terms of the deal were not disclosed.

As part of the deal, Genetics' cytogenetics training facility one of five accredited cytogenetics training facilities in the US will be transferred to Poplar.

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Poplar Healthcare Acquires Genetics of Memphis - 360Dx (subscription)

Researchers identify a key controller of biological machinery in cell’s … – Phys.Org

June 6, 2017 First author Angela Arensdorf, Ph.D., and corresponding author Stacey Ogden, Ph.D., an associate member of the St. Jude Department of Cell and Molecular Biology. Credit: Peter Barta / St. Jude Children's Research Hospital

St. Jude Children's Research Hospital molecular biologists have identified an enzyme that activates and "supercharges" cellular machinery that controls how cells become specialized cells in the body.

Malfunction of that machinery, dubbed the Sonic Hedgehog pathway, causes a variety of developmental disorders and cancers, including childhood medulloblastoma and basal cell carcinoma. Researchers believe their basic discovery opens a new research pathway that could lead to drugs to treat such disorders.

Led by Stacey Ogden, Ph.D., an associate member of the St. Jude Department of Cell and Molecular Biology, the research was published June 6 in the journal Cell Reports.

The scientific puzzle the researchers sought to understand was how a major activator of the Sonic Hedgehog pathway, called Smoothened, manages to make its way into an antenna-like cell structure called a "primary cilium," where it communicates with its downstream signaling partners.

Every cell in the body sprouts a primary cilium, which harbors a whole factory of cellular machinery that the cell uses to translate external stimuli into cell responses. Such stimuli include mechanical movement and chemical signals such as hormones. Normally, Smoothened is barred from the primary cilium, keeping the Sonic Hedgehog pathway safely controlled.

In their experiments with cell cultures, the researchers discovered that an enzyme called Phospholipase A2 triggers a mechanism that opens the way for Smoothened movement into the cilium. What's more, the phospholipase triggers an amplification that "supercharges" Smoothened signaling.

"We've basically revealed a new layer of regulation of Smoothened trafficking," Ogden said. "This is a very hot area of research now, because Smoothened trafficking appears to be a very crucial control point for signaling activity. So, if you can change Smoothened trafficking, you can very easily adjust the amplitude of Sonic Hedgehog signaling."

The basic finding has potential clinical importance, Ogden said, because reduced activity in the Sonic Hedgehog pathway is commonly found in genetic disorders of primary cilia function. These disorders include Joubert syndrome, Bardet-Biedl syndrome, Ellis van Creveld syndrome and polycystic kidney diseaseone of the most common genetic diseases in the U.S., affecting more than 600,000 people. Better understanding of the control machinery for the Sonic Hedgehog pathway could lead to more effective therapies for the disorders, Ogden said.

Conversely, hyperactivity of the Sonic Hedgehog pathway is the cause of about 30 percent of childhood medulloblastomas. Medulloblastoma is the most common malignant brain tumor of childhood, accounting for about 20 percent of all childhood brain tumors. Current treatments using surgery, radiation and chemotherapy cause severe side effects, so more precise drug treatments are urgently needed.

"One of the drugs now being used to treat medulloblastoma is a Smoothened inhibitor," Ogden said. "But tumor cells frequently become resistant to this drug and begin to grow again because of mutations in Smoothened that enable it to overcome the drug's inhibition. We want to determine whether drugs to inhibit Phospholipase A2 could reduce Sonic Hedgehog activity in cases where Smoothened becomes insensitive to targeted inhibition."

In adults, Hedgehog pathway hyperactivation also causes basal cell carcinoma, the most common skin cancer and one of the most common cancers. Hedgehog pathway activation also may accelerate other types of tumors by affecting the tissue surrounding the tumor, called the stroma, to create an environment more conducive to growth, Ogden said.

"So Hedgehog pathway inhibitors may be useful in combination therapies with other traditional chemotherapies for other types of solid tumors," she said.

In further research, Ogden and her colleagues are continuing to examine Smoothened regulation and exploring drugs that affect its activity.

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The number of conferences on epigenetics has been increasing in the past decade, underscoring the impact of the field on a variety of areas in biology and medicine. However, the mechanistic role of the epigenome in adaptation and inheritance, and how the environment may impinge on epigenetic control, are topics of growing debate. Those themes were the focus of the inaugural international King Abdullah University of Science and Technology (KAUST) Research Conference on Environmental Epigenetics in Saudi Arabia, where more than 100 participants from 19 countries enjoyed vibrant scientific discussions and a pleasant February breeze from the Red Sea.

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New med school will have expanded gross anatomy lab – Buffalo News

Gross anatomy classes often are a rite of passage for medical school students, and so it soon will be at theUniversity at Buffalo's new medical school.

The Jacobs School of Medicine and Biomedical Sciences will showcase a cutting-edge gross anatomy lab on its seventh floor that is centralized and has 30 tables in its main area. In all, there will be 50 tables for gross anatomy and continuing medical education purposes.

"This will be a pretty innovative gross anatomy lab," said Dr. Michael E. Cain, dean of the medical school.As students dissect, they will have images directly in front of them, through CT scans and MRI scans.

Gross anatomy is taught every year to every medical student. The course is taught in the fall, so it will be taught this September on South Campus because the new medical school will not be open for classes until early next year.

The lab also will feature side labs designed for use by peopleand community groups not involved in primary anatomy instruction. These side labs are a new addition, allowing for enhanced use by other departments in the medical school and also by outside groups for continuing education. Students from other colleges and even some high schools, emergency medical doctors and dental oral surgeons will use the lab for practice. Paramedics could also use the lab regularly to train for intubation. Those training sessions currently have to be scheduled when classes are not in session.

In addition to gross anatomy being taught in the new building, it also will continueto be taught on South Campus for dental students and undergraduates.

Reporter Karen Robinson covers the Buffalo NiagaraMedicalCampus.Follow her on twitter at@krobinsonBNor reach her by email atkrobinson@buffnews.com.

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