All posts by medical

Cell Biology

A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion – Nature.com

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A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion - Nature.com

Cell Biology

Yoshihiro Yoneda Appointed President of the International Human Frontier Science Program Organization – PR Newswire

STRASBOURG, France, June 26, 2024 /PRNewswire/ -- The International Human Frontier Science Program Organization (HFSPO) is pleased to announce that acclaimed Japanese cell biologist and international research leader Yoshihiro Yoneda will assume the role of President for the global life science organization.

"We are thrilled to welcome President Yoneda, a pioneer in cellular biology and a science leader, who has made such positive impacts on key research institutions," said Pavel Kabat, HFSPO Secretary General.

Yoneda will serve as the 7th President in HFSPO's 35-year history, successor to President Shigekazu Nagata, who served from 2018 to 2024.

"It is with deep gratitude that we thank President Nagata for his years of service and dedication to HFSPO at all levels," said Kabat. "His wisdom and insight have been invaluable."

Chartered by the G7 in 1987, HFSPO supports pioneering, interdisciplinary research in the life sciences through Research Grants and Fellowships. It is funded by 16 Member countries, plus the European Commission. HFSP research proposals are evaluated through peer review and only the most daring, ground-breaking research all involving international collaboration is supported. HFSP has issued over 4,500 awards involving over 8,500 international scientists. Since the beginning of the Program,29 HFSP awardees have gone on to win the Nobel Prize.

Yoneda was nominated by the Government of Japan; the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Ministry of Economy, Trade and Industry (METI); and unanimously confirmed during the June meeting of the HFSPO Board of Trustees, held this year in Washington, D.C.

He is Professor Emeritus at Osaka University and President of The Research Foundation for Microbial Diseases of Osaka University (BIKEN Foundation). From 2015 to 2022, he led the National Institutes of Biomedical Innovation, Health and Nutrition. He also served as Director of the World Health Organization Collaborating Centre for Nutrition and Physical Activity.

Yoneda has a longstanding connection to HFSPO. He was awarded two HFSP Research Grants in 1998 and 2001 that led to important discoveries in molecular mechanisms of nucleocytoplasmic transport.

"I am honored to be entrusted with this important role for such an impactful, global organization," said Yoneda. "HFSPO is one of the few organizations in the world focused on creating quantum leaps in scientific knowledge. Through such research we have a chance to do great things for humanity."

For more information or to schedule interviews, contact Rachael Bishop, Science Writer and Editor: phone: +33 (0)7 81 87 62 21 or email: [emailprotected]

The International Human Frontier Science Program Organization is headquartered at 12 Quai Saint-Jean, 67000, Strasbourg, France. http://www.hfsp.org | Office phone: +33-(0)3 88 21 51 23 | @HFSP Twitter | Facebook page

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Yoshihiro Yoneda Appointed President of the International Human Frontier Science Program Organization - PR Newswire

Anesthesiology

An Interview with Dr. Anna Bowling Insights from a Dedicated Anesthesiologist and Coach – OCNJ Daily

Dr. Anna Bowling and her career in anesthesiology, marked by her dedication to patient care and her innovative approach to pain management, has also embraced a unique integration of coaching. Raised in North Carolina, Dr. Bowling moved to California in 2014 for her residency in anesthesiology at the University of California, Irvine, where she later completed a fellowship in acute pain management and regional anesthesia. Since 2018, she has been in private practice, working at several ambulatory surgery centers and incorporating her coaching skills to enhance her medical practice.

In this interview, Dr. Anna Bowling shares her journey, professional values, and insights into how coaching has influenced her approach to medicine.

I always looked forward to learning science and wanted to pursue a career in a STEM field. I wanted a life of purpose. Inherent interest, aptitude, and desire for contribution naturally led me to decide at a young age to pursue medicine.

When my best friends mom had emergent surgery for a ruptured intracranial aneurysm, I was amazed at what the doctors were able to do. They saved her life and gave the family their loved one back. Medicine became my calling. I wanted to help the sickest patients and be a pillar of strength on someones darkest days. This is what we do as anesthesiologists. We have the enriching and meaningful task of keeping patients safe through their surgeries and returning them to their loved ones.

I am passionate about making surgery as easy as possible for patients. I chose to do a fellowship in regional anesthesia because it helps achieve this aim. Regional anesthesia injects local anesthetic under ultrasound guidance precisely at the site where nerves or nerve bundles are located to achieve numbness of a specific body part, such as the shoulder, arm, or leg. I remember learning to do this procedure in residency and was amazed at how well it worked for shoulder surgery. My patients would awaken cognitively precise and pain-freelike nothing even happened except their arm is asleep. Of course, I must warn them that this medicine will eventually wear off, and they should be prepared. However, with the regional block, they wont sense any pain for 12-24 hours, which is when post-op pain tends to be the worst.

Regional anesthesia is also highly beneficial for elderly or otherwise high-risk patients. For example, if your grandmother falls and breaks her wrist, instead of putting her under general anesthesia, which carries more risk, we can numb her arm and give her sedation to sleep lightly. Im a huge advocate for regional anesthesia as a component of multi-modal, opioid-sparing anesthesia. Being a part of this pivot toward better patient care has reinforced my passion for medicine.

I value hard work, respect, honesty, and having a growth mindset.

Get a coach! My journey into life coaching has taught me more in a couple of years than Id absorbed in a lifetime. Examine your mind. It can be your best friend or your worst enemy.

Im proud of being humble, genuine, and caring. Im proud of staying true to myself no matter what. I have learned to draw strength from from any negative experience.

We focus on whats important and take care of that first. As anesthesiologists in a crisis, we focus on maintaining the patients vital organ functions and intervening where necessary. We can tune out everything that doesnt matter and communicate what is needed. Generally, I take the same approach in life, focusing my energy and time on whats most important.

Time and energy are the currency of your life. Reducing my life to what matters eliminates clutter, which manages stress and helps me feel that I am living my life purposefully. Remembering my purpose and reason for becoming a doctor keeps me balanced even when life gets unbalanced. Measuring our work-life balance like a pie chart is not realistic or helpful. At times, you will need to lean into your career, and at times, you will need to lean into your personal life.

Learning to shift your energy where its needed when its required ultimately leads to greater satisfaction in life. If you consciously maintain a sense of purpose in your work, no matter how difficult, it doesnt become something that must be counterbalanced. For me, the usual complaints of those in healthcare, such as dealing with challenging personalities, unrealistic expectations of others, unrealistic expectations, and high emotions, can all be softened through listening and understanding. Doing so has allowed me to function in a meaningful way that also helps those around me to keep feeling fulfilled and passionate about their work. Healthcare is a team sport; we must look out for each other. We all have the same goal. What we can deliver is fantastic when we work together, support each other, and lean on one another when we have to.

I define success as living a life that is fulfilling. When we spend our time doing something meaningful, we are more effective, learn more, and contribute more.

Whenever I need inspiration, I listen to David Goggins. David Goggins didnt let anything or anyone stop him from achieving his goals. He is the epitome of self-made.

Ive overcome most of the obstacles in my life on my own, but lately, Ive been learning from many great authors. After reading, The Body Keeps the Score, a book about post-traumatic stress disorder, I was awakened to how much possibility I was letting myself miss out on . It helped me understand my own experiences of trauma and break out of the darkness that it had brought. The silver lining of trauma is something called post-traumatic growth. Post-traumatic growth can be profound and more significant than it may otherwise have been. So, in essence, the most influential relationship in my life has been the one I have with myself. Through the words of authors like David Goggins, Bren Brown, Viktor Frankl, and Ryan Holiday, I have learned some of the greatest lessons in life.

Dr. Anna Bowling and her journey through medicine and coaching underscores the importance of dedication, continuous learning, and personal growth. Her insights into patient care, stress management, and work-life balance reflect a deeply thoughtful approach to her profession and personal life. Dr. Bowlings story is an inspiring example of how embracing challenges and seeking personal development can lead to a fulfilling and impactful career.

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An Interview with Dr. Anna Bowling Insights from a Dedicated Anesthesiologist and Coach - OCNJ Daily

Anesthesiology

Mitchell Named Fellow of American Association of Nurse Anesthesiology – The Elm – The Elm

Mitchell Named Fellow of American Association of Nurse Anesthesiology June 21, 2024 Mary Therese Phelan

As a newly selected fellow of the American Association of Nurse Anesthesiology, Jacqueline Mitchell is recognized as one of the most accomplished leaders in the nurse anesthesia profession.

Retired Col. Jacqueline C. Mitchell, MS 07, CRNA, FAANA, director of clinical education in the University of Maryland School of Nursing (UMSON) Doctor of Nursing Practice Nurse Anesthesia specialty, has been selected for induction as a 2024 fellow of the American Association of Nurse Anesthesiology (AANA). She will be inducted during AANAs Annual Congress in San Diego on Aug. 3.

As a fellow of the AANA, she is recognized as one of the most accomplished leaders in the nurse anesthesia profession. Earning the FAANA designation is a major career achievement that opens doors for certified registered nurse anesthetists as practitioners, educators, researchers, and advocates for the profession. The FAANA designation communicates a commitment to excellence, and acceptance criteria include contributions that have made a sustainable impact in the areas of clinical practice, education, research, and professional advocacy.

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Mitchell Named Fellow of American Association of Nurse Anesthesiology - The Elm - The Elm

Anesthesiology

Department of Anesthesiology announces newly promoted faculty | Newsroom – University of Nebraska Medical Center

Several UNMC Department of Anesthesiology faculty members have a reason to celebrate following promotion announcements last month. Each is a distinguished professional in their field who is committed to upholding the mission clinical excellence, outstanding education and innovative research.

Promotion marks a major milestone in the academic lives of UNMC faculty, said Mohanad Shukry, MD, PhD, interim chair of the department. It demonstrates that they not only have met the high standards of their specialties but made significant contributions in their areas of responsibility and to the success of the department, as well.

Promoted to Professor

Promoted to Associate Professor

Promoted to Assistant Professor

We are truly fortunate to have such incredibly talented and dedicated faculty in the department, Dr. Shukry said. I invite the entire department of anesthesiology to join me in congratulating your colleagues.

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Department of Anesthesiology announces newly promoted faculty | Newsroom - University of Nebraska Medical Center

Anesthesiology

Mitchell Named Fellow of American Association of Nurse Anesthesiology – University of Maryland School of Nursing

Baltimore, Md. Retired COL. Jacqueline C. Mitchell, MS 07, CRNA, FAANA, director of clinical education in the University of Maryland School of Nursing (UMSON) Doctor of Nursing Practice Nurse Anesthesia specialty, has been selected for induction as a 2024 Fellow of the American Association of Nurse Anesthesiology (AANA). She will be inducted during AANAs Annual Congress in San Diego on Aug. 3.

As a Fellow of the AANA, she is recognized as one of the most accomplished leaders in the nurse anesthesia profession. Earning the FAANA designation is a major career achievement that opens doors for certified registered nurse anesthetists as practitioners, educators, researchers, and advocates for the profession. The FAANA designation communicates a commitment to excellence, and acceptance criteria include contributions that have made a sustainable impact in the areas of clinical practice, education, research, and professional advocacy.

Being recognized is exciting and a humbling experience. It is a gift of inspiration to keep moving the profession forward, Mitchell said.

Mitchell joined the UMSON faculty as a clinical instructor in 2009. In her present role, she has oversight responsibility for 25 clinical rotation sites. Additionally, she lectures in several anesthesia practicum courses and works with students in simulation lab activities, workshop exercises, and competency sessions.

Mitchell retired as Colonel from the U.S. Army Nurse Corps in 2021. She served in the military for 30 years in a variety of clinical and command leadership assignments and deployments, including four years of active duty and 26 years of Reserve time.

Mitchell most recently served at the U.S. Army Medical Command in Texas as a nurse methods analyst, Drilling Individual Mobilization Augmentee. In this role, she was responsible for developing, analyzing, revising, and staffing organizational policies, standards, and practices related to health care delivery for medical specialties and nursing specialties across all Army components, including Reserve Component clinical issues.

Mitchell earned her Master of Science in Nurse Anesthesia and Certificate in Teaching in Nursing and Health Professions from UMSON, a Master of Science in Exercise Fitness and Health Promotion from George Mason University, and a Bachelor of Science in Nursing from the City College of New York. She is working toward a PhD in Nursing at UMSON, anticipating completion this December.

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The University of Maryland School of Nursing, founded in 1889, is one of the oldest and largest nursing schools in the nation and is ranked among the top nursing schools nationwide. Enrolling nearly 2,000 students in its baccalaureate, masters, and doctoral programs, the School develops leaders who shape the profession of nursing and impact the health care environment.

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Mitchell Named Fellow of American Association of Nurse Anesthesiology - University of Maryland School of Nursing

Anesthesiology

Medical Student Education | Anesthesiology & Critical Care Medicine | UNM School of Medicine | School of Medicine – The University of New Mexico

All third year UNM medical students complete a one-week rotation in anesthesia. This rotation is conducted through the Department of Anesthesiology and Critical Care.

As a medical student in this phasetworotation, you will learn basic concepts in applied pharmacology, pharmacokinetics, IV placement and airway management. These skills are crucial not only for those becoming anesthesiologists, but for physicians in other specialties such as family practice.

Build on your current medical and pharmacology knowledge.Examples of concepts you will learn include:

You will also participate in an interactive teaching sessionusingsimulated patientsto practice general anesthesia scenarios.

Several sessions of your rotation involve using passive mannequins to learn proper placement of IV lines and the essentials of advanced airway management. Master these skills on a mannequin and then spend two days in the operating room using these interventions on patients.

All students are expected to demonstrate insertion of a laryngeal mask airway, use an effective bag-mask ventilation on an anesthetized patient and start two IVs. You will be encouraged to perform endotracheal intubation, if possible.

Timewill be spent in the high-fidelity human simulator lab. Gain experience in applied pharmacology as well as additional experience in airway management in the context of patient scenarios.

At the end of rotation, the students will have experience in didacticsincluding practical experiencein IV and airway, hands on experience in the operating room and simulation environments. For more information, contact PramodPanikkath, MD,AssociateProfessor, atPPanikkath@salud.unm.edu.

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Medical Student Education | Anesthesiology & Critical Care Medicine | UNM School of Medicine | School of Medicine - The University of New Mexico

Anesthesiology

How we help 100000 surgical patients have positive experiences – Fraser Health Authority

Did you know that we perform more than 100,000 surgeries every year? This episode explores how we prepare patients for surgeries, how we support their recoveries, and everything that happens in between to help them have positive experiences.

Join host Dr. Victoria Lee for a fascinating conversation with Dr. Dave Konkin and Dr. Feisal Mohamedali, our regional medical directors and department heads for Surgery and Anesthesiology, respectively.

And be sure to subscribe to The Heart of It in your favourite podcast player app so you dont miss a beat.

Or listen to this episode in your favourite podcast player app.

Listen on Apple Podcasts Listen on Spotify Listen on Overcast Listen on Amazon Music Listen on Podcast Addict Listen on Castbox Listen on iHeartRadio Listen on Pocket Casts RSS Feed

Dr. Dave Konkin is Fraser Healths regional medical director and department head for Surgery. His expertise lies in performing various major abdominal operations, including gastrointestinal, colorectal, gallbladder, trauma and hernia surgeries.

Dr. Feisal Mohamedali is Fraser Healths regional medical director and department head for Anesthesiology. His team specializes in caring for seriously injured patients resulting from car accidents, gunshots and stabbings.

Every episode, Dr. Victoria Lee, president and CEO of Fraser Health, take listeners to the heart of health care, where passion, dedication and innovation drive individual, community and planetary health.

Listen to and watch more episodes of The Heart of It here.

This episode of The Heart of It was recorded on the traditional, ancestral and unceded shared territories of the xmkym (Musqueam), Skwxw7mesh (Squamish) and slilwta (Tsleil-Waututh) Nations, and home to the Vancouver Sea to Sky Mtis Association.

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How we help 100000 surgical patients have positive experiences - Fraser Health Authority

Anesthesiology

Doctors perform kidney transplant on awake patient, who is out of hospital in 1 day – KERO 23 ABC News Bakersfield

Doctors at Northwestern Memorial Hospital in Chicago have performed a kidney transplant on a patient who was awake the whole time.

They say the technique used updated anesthesia methods which may now be used for more patients who would be considered too risky to go fully under, which is the standard now.

The patient, 28-year-old kidney disease patient John Nicholas, paves the way for more patients who are older and have more risks.

"There are a lot of people that have heart and lung disease that also need a kidney transplant, and that just increases the risk of general anesthesia even more," Dr. Satish Nadig, Comprehensive Transplant Center director and chief of abdominal transplant surgery at Northwestern Memorial Hospital in Chicago told Scripps News.

"There's a lot of people out there [and] they're very high risks for intubation, meaning getting a tube put into their throat to help them breathe. Very high risk for being on a ventilator. A lot of older people that need kidney transplants get cognitive or neurologic issues after general anesthesia," said Dr. Nadig.

Right now, kidney transplants are usually done with a patient fully unconscious under general anesthesia. In Nicholas' case, doctors used a spinal shot, also used in abdominal and pelvic surgeries like cesarean sections to deliver babies.

Relateds story: Researchers testing new bionic kidney for kidney disease patients

"Doing anesthesia for the awake kidney transplant was easier than many C-sections," Dr. Vicente Garcia Tomas, chief of regional anesthesiology and acute pain medicine at Northwestern Memorial Hospital said in a press release. "For John's case, we placed a spinal anesthesia shot in the operating room with a little bit of sedation for comfort. It was incredibly simple and uneventful, but allowed John to be awake for the procedure.

Being awake meant no invasive ventilator, and Nicholas used his own lungs. He could breathe, talk and interact with doctors. Other benefits include a shorter procedure and a faster and smoother recovery.

"He required zero opioid or narcotic pain medication. He was asking to eat, even during the surgery. That was a question he asked me while we were sewing the kidney in: 'When can I eat?'" Nadig said.

Nicholas went home after just one night in the hospital following his transplant, which is much shorter than the typical several days to a week post-kidney transplant.

That lowers the chance for complications. Research shows infection, bed sores, and bad drug reaction risk goes up the longer someone stays in the hospital.

Next, Nadig says they've identified five more patients for awake kidney transplants, opening the door to those considered too risky for general anesthesia.

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Doctors perform kidney transplant on awake patient, who is out of hospital in 1 day - KERO 23 ABC News Bakersfield

Biology

Meta alum launches AI biology model that simulates 500 million years of evolution – VentureBeat

Dont miss OpenAI, Chevron, Nvidia, Kaiser Permanente, and Capital One leaders only at VentureBeat Transform 2024. Gain essential insights about GenAI and expand your network at this exclusive three day event. Learn More

As the world continues to explore the potential of GPT-4o beating Claude 3.5 Sonnet, EvolutionaryScale, an AI research lab founded by former Meta engineers, who ran the companys now-disbanded protein-folding team, is moving in a completely different domain: making biology programmable.

The task sounds complicated, but the year-old company is already making waves. Today, it announced the launch of ESM3, a natively multimodal and generative language model that can follow prompts and design novel proteins. In tests, the model was able to generate a novel green fluorescent protein (esmGFP), which would have taken hundreds of millions of years to evolve naturally.

esmGFPhas a sequence that is only 58% similar to the closest known fluorescent protein. From the rate of diversification of GFPs found in nature, we estimate that this generation of a new fluorescent protein is equivalent to simulating over 500 million years of evolution, the company wrote in a pre-print paper posted on its website on Tuesday.

In addition to the new model, which comes in three sizes, the startup announced it has raised $142 million in a seed round of funding, led by Nat Friedman, Daniel Gross and Lux Capital. Amazon and Nvidias venture capital arm also participated in the round. The smallest model has also been open-sourced to accelerate research with the new models.

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However, building the model is just the start and it remains to be seen how impactful it will be in the real world.

While generative AI models have evolved a lot, especially in understanding and reasoning with human language, many have wondered if we can train these models to decipher the core language of life and then use them to develop novel molecules. The core molecules of life RNA, proteins and DNA evolved over the last 3.5 billion years through natural chemical reactions. So, having a way to program biology and design new molecules could pave the way to solve some of the biggest challenges faced by humanity, including climate change, plastic pollution and conditions like cancer.

Multiple organizations, including Google Deepmind and Isomorphic Labs, are already in this space, and the latest one to join the fray is EvolutionaryScale. The company, founded in 2023, developed a few protein language models over the last few months, but its latest offering, ESM3, is the largest of all and natively multimodal and generative.

Described as a frontier generative model for biology, ESM3 was trained with 1 trillion teraflops of computing power on 2.78 billion natural proteins sampled from various organisms and biomes and 771 billion unique tokens. It can jointly reason across three fundamental biological properties of proteins: sequence, structure and function. These three data modalities are represented as tracks of discrete tokens at the input and output of ESM3. As a result, the user can present the model with a combination of partial inputs across the tracks, and the model will provide output predictions for all the tracks, generating novel proteins.

ESM3s multimodal reasoning power enables scientists to generate new proteins with an unprecedented degree of control. For example, the model can be prompted to combine structure, sequence and function to propose a potential scaffold for the active site of PETase, an enzyme that degrades polyethylene terephthalate (PET), a target of interest to protein engineers for breaking down plastic waste, the company explained.

In one case, the company was able to use the model with chain-of-thought prompting to design a novel version of green fluorescent protein, a rare protein that can attach to and mark another protein with its fluorescence, enabling scientists to see the presence of the particular protein in a cell. EvolutionaryScale found that the generated version of this protein has brightness characteristics as natural fluorescent proteins. It would have taken nature 500 million years to evolve this generation of protein.

The team also noted that ESM3 can self-improve, providing feedback on the quality of its generations. Feedback from lab experiments or existing experimental data can also be applied to align its generations with goals.

As of now, ESM3 is available in three sizes, small, medium and large. The smallest one, with 1.4B parameters, has been open-sourced with weights and code on GitHub under a non-commercial license. Meanwhile, the medium and large versions going up to 98B params are available for commercial use by companies through EvolutionaryScales API and platforms from partners Nvidia and AWS.

EvolutionaryScale hopes researchers will be able to use the technology to solve some of the biggest problems of the world and benefit human health and society. However, its broader applications by companies remain to be seen. The biggest possible beneficiary of the technology could be pharmaceutical companies that could lead the development of novel medicines targeting life-threatening conditions.

Previous models from the company were used in use cases such as improving therapeutically relevant characteristics of antibodies as well as detecting COVID-19 variants to could pose a major risk to public health.

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Meta alum launches AI biology model that simulates 500 million years of evolution - VentureBeat