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Anatomy

Anatomy Of A Love Triangle: Reporter And Church Choir Director Tries To Kill Man To Be With His Wife – Oxygen (blog)

Rob Whedbee woke up to the smell of cigarette smoke. Big problem: nobody in his house smoked. He opened his eyes to see a figure approaching him in his bed, silhouetted by the streetlight outside. The figure was carrying a knife according to Snapped on Oxygen.

He had one foot on the ground and he had one knee on the bed straddling me. You know, preparing to stab me or cut my throat, Rob said. He jumped out of the bed and began fighting the intruder. Robs wife Lisa appeared in the bedroom doorway with a baseball bat. Rob yelled to his wife for help but she just stood there. Then the intruder began yelling at Lisa. Hit him. Youve got to do it and youve got to do it now.

Lisa and Rob met in 1979, when they were both out driving. Rob asked Lisa, then 17, out on a date. She was smitten by the former high school football player turned college freshman. They dated for two years, and friends called them Barbie and Ken.

The seemingly dreamy couple wed in 1982. Rob began working for his familys insurance agency and so did Lisa until she had children. They bought a home and in 1986, they gave birth to their first child Justin. Their relationship was flourishing, even with the new baby. Sometimes Lisa and Rob would even slip off for a romantic weekend alone at their vacation condo in the Smoky Mountains.

The problems began after the birth of the couples daughter Brittany in 1990. The doctor informed the Whedbees that Brittany had been born with Down Syndrome and a heart defect. According to Rob, Lisa took the news very hard. Brittany survived multiple surgeries and, despite her medical problems, grew into a loving little girl. But, Lisa was having a hard time dealing with it. According to Rob, she never quite adjusted to the day-to-day stress of being a stay-at-home mom to a child with special needs.

Something like that sometimes as they say it can make you or break you and I think it broke her, he said.

Friends noticed that Lisa became more withdrawn. The birth of Brittany put a strain on her and Robs relationship. According to Rob, she became distant and in the spring of 1993, she suggested they get a divorce. Rob didnt like that idea.

The two went went to counseling at their church and tried to tough it out. That prompted Lisa to take a more active role at their Trinity Methodist. Lisa even signed up for the church choir, where she met a man named Michael Frazier. He was an organist who directed the church choir. He was also a reporter for the local newspaper. Oh, and he was a big time chain-smoker.

Paul Jones, a friend of Lisas, called Michael odd.

When he played he had that Phantom of the Opera kinda thing going on.

On Mothers Day in 93, Michael wrote a newsstory about the Whedbees, specifically Lisa, about raising Brittany.

I dont think my name was even mentioned in that story, said Rob. It was one of those things that you look at and you say huh thats kind of strange. You know where am I? Im left out and shes mother of the year.

Around this time, Lisa began coming home late on a regular basis. Rob began suspecting that Lisa and Michael were having an affair.

His suspicion was right, and it was a lot deeper than an average affair.

Rob recognized Michael's voice as he was attacking him.

So, I just stood up and picked him up over my head and slammed him into the corner by the nightstand and took off out of the room. And as I went past Lisa I took the baseball bat away from her. I squared off in the middle of the garage. I had the bat; he came out into the light and he had that knife in his hand, rubber gloves on, stocking mask, a black tee shirt.

Not just any tee. It was a 'Phantom of the Opera' shirt. As Rob left the house, Michael went back inside, shut that door and locked it. Enraged about the attempt on his life, Rob circled the house, beating on the gutters with the baseball bat. A neighbor heard the commotion and found Rob covered in blood, walking around in his underwear. The neighbor was stunned by the news that their choir director had just tried to kill Rob. They called 911.

While police were en route, Lisa came out of the house and walked up to Rob, pretending she didnt know what happened and that she didnt know who the attacker was.

Police arrived and interviewed Lisa. They noticed that she didnt seem that concerned about her husband. Placed in the back of a patrol car and read her rights, Lisa still denied being in on the attack, but she did confirm the identity of her husbands attacker. Frazier was also arrested. He confessed to both an affair with Lisa and to being the hit man in Rob's murder plot.

Lisa and Michael were both booked on attempted murder charges. Lisa was also charged with solicitation to commit murder.

Joe Anderson, friend of Rob, said he was very shocked by Lisas taste in the other man.

She could go out, being an attractive girl, and get basically anybody she wanted. Why would she cheat with someone like this?

The unlikely love triangle caught the attention of national news outlets like People, Dateline, CNN and Hard Copy.

Now it was Rob who wanted the divorce. He filed and Lisa, despite her earlier desire to end the marriage, contested. Because of LIsas attempted murder charges, Rob was able to obtain temporary custody of the couples two children. He also obtained a restraining order against Lisa, who was out on $50,000 bond. Awaiting trial, Lisa continued her affair with Michael Frazier, who was also out on $50,000 bond. The former choir director frequently visited Lisas condo, the once romantic getaway for her and Rob, even though Lisa was under specific direction from the judge to not see Michael.

Lisa began claiming the Rob was physically abusive to her. She also said he threatened her life when she tried to divorce him. Rob denied the allegations, arguing that they were all about diverting attention from her pending criminal case.

Michaels trial came first. In their opening statements, prosecutors argued that the attempt on Robs life was the result of meticulous planning on the part of Lisa and Michael. The defense admitted that with the knife in the Whedbees bedroom in their open. But, they argued he had a very legitimate reason to attack Rob: Lisa told Michael that Rob abused and sexually assaulted her. And, soon, the very non-threatening Michael took the stand.

It was important not only what Michael said, but to allow them [the jury] to see this very diminutive, almost kind of dorky and, and, in ways, effeminate person, said Michaels attorney, Greg Isaacs.

I was going to do whatever I had to do to protect Lisa, Michael said to the court.

Prosecutors claimed that Lisas looks made it easy for her to manipulate the choir director.

The jury found Michael Frazier guilty but not of attempted murder. They convicted Frazier of the lesser charge of attempted manslaughter, punishable by a maximum of only four years in prison. The judge sentenced him to all four.

Lisa didnt have a trial. She opted for a plea deal instead. She entered an Alford Plea, in which a defendant never admits guilt, but pleads guilt because they believe it to be in their best interest to do so. Lisa served less than a year in jail, followed by three years probation.

Neither one of them got what they deserved. Thats a fact, said Rob.

Lisa has since remarried, and built a new life in another state.

Lisas attorney, David Eldridge, said, Among the saddest of the chapters is the destruction of the relationship that she had, very positive relationship she had with the children and thats a huge price to pay, and shes paid it Im afraid.

Rob raised Justin and Brittany as a single dad.

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Anatomy Of A Love Triangle: Reporter And Church Choir Director Tries To Kill Man To Be With His Wife - Oxygen (blog)

Human Behavior

Self-Driving Cars Will Soon Make Moral Decisions As Well As Humans – IFLScience

In his book The Descent of Man, and Selection in Relation to Sex, Darwin proudly argued that our sense of morality was a uniquely human trait. Even though that claim has been disputed in recent years, its fair to say humans still top the charts when it comes to moral senses.

But it looks like we might soon have some competition, namely in the form of driverless cars.

A new study in the journal Frontiers in Behavioral Neuroscience has looked at human behavior and moral assessments to see how they could be applied to computers.

Just like a human in a car, a driverless car could be faced with split-second moral decisions. Picture this: A child runs into the road. The car has to work out whether it hits them, veers off to hit a wall and potentially kill other passersby, or hit the wall and potentially kill the driver.

It was previously assumed that this kind of human morality could never be described in the language of a computer as it was context dependent.

But we found quite the opposite, Leon Stfeld, first author of the study, said in a statement.

Human behavior in dilemma situations can be modeled by a rather simple value-of-life-based model that is attributed by the participant to every human, animal, or inanimate object."

They worked this out by asking participants to drive a car in a typical suburban neighborhood on a foggy day in an immersive virtual-reality simulation. During the simulation, they were faced with unavoidable crashes with inanimate objects, animals, people, etc. Their task was to decide what object the car crashes into.

The results were then plugged into statistical models leading to rules to work out how and why a human reached a moral decision. Remarkably, patterns emerged.

Now we have worked out the laws and mechanics in the way a computer would understand, it means we could now simply teach machines to share our morality. This will have some huge implications in regards to self-driving cars.

We need to ask whether autonomous systems should adopt moral judgments, if yes, should they imitate moral behavior by imitating human decisions, should they behave along ethical theories and if so, which ones, and critically, if things go wrong who or what is at fault? senior author Professor Gordon Pipa said.

"Now that we know how to implement human ethical decisions into machines we, as a society, are still left with a double dilemma," Professor Peter Knig, another senior author, added. "Firstly, we have to decide whether moral values should be included in guidelines for machine behavior and secondly, if they are, should machines act just like humans."

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Self-Driving Cars Will Soon Make Moral Decisions As Well As Humans - IFLScience

Genetics

BRIEF-Seattle Genetics reports 8.2 percent stake in Immunomedics as of June 29, 2017 – Reuters

UPDATE 1-Tesla April registrations drop in key California market

SAN FRANCISCO, July 6 Registrations of Tesla Inc vehicles in California, by far the largest market of the luxury electric car maker, fell 24 percent in April from a year ago, according to data from IHS Markit.

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BRIEF-Seattle Genetics reports 8.2 percent stake in Immunomedics as of June 29, 2017 - Reuters

Biochemistry

University Of Tulsa Partners With Marshall Brewing Company – News On 6

TULSA, Oklahoma -

When you think of beer, you don't usually associate it with labs, books and lots of studying,but the University of Tulsa is looking to change just that.

The school is partnering with Marshall brewing company.

TU and Marshall Brewing Company are teaming up to offer a beer brewing certificate program all in the name of science.

Jeremy Sabo is an intern at Marshall Brewing.

He received his bachelor's degree in Biochemistry from TU.

He is also helping set up a unique program at TU, a beer brewing certificate program in a partnership with Marshall Brewing.

"We'll have, basically six classes, so three of those are already offered in the chemistry and biochemistry department," Sabo said.

Sabo says his curiosity is what drives his love of science and beer.

He says the changing laws surrounding alcohol in the state got the ball rolling.

The idea was proposed by a TU professor.

"So you'll get the history, you'll get, how beer's brewed and why it's important, and all of the lab techniques that go along with quality control and quality assurance," Sabo said.

Sabo even took us over to a lab at TU, showing us some of the science behind the beer.

"There's calories, proteins, carbohydrates, and all those need to be determined and those are done through scientific instrumentation and someone needs to know how to operate those," Sabo said.

He says the great part about this program is that anyone age 21 and older can take it, giving them hands-on experience, while also creating many opportunities.

"For the breweries that are going to be expanding, to both have students and then for students that want a job, and may don't wanna go work for a big company and go work in beer," Sabo said.

That certificate program is set to begin in the spring of 2018.

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University Of Tulsa Partners With Marshall Brewing Company - News On 6

Biochemistry

Kent State chemistry department and patent-holding professor dies – Kent Wired

Students and faculty of the chemistry and biochemistry department at Kent State are grieving the death of researcher and professor Anatoly Khitrin.

Khitrin, 62, passed away due to cancer and heart related problems earlier this week.

Calling hours for Khitrin begin Sunday from 2 p.m. to 4 p.m., followed by a service until 5 p.m. at Bissler Funeral Home in Kent.

Khitrins coworkers said it was a pleasure to work with him.

I worked with him for 15 years, and he was such a wonderful man, said Erin Michael-McLaughlin, the chemistry department program coordinator. He had a very dry sense of humor and was one of the most intelligent men I have ever met.

Songping Huang, a chemistry and biochemistry professor, said he worked very closely with Khitrin and cherished the relationship they had.

I remember he once told me this story as to why he shouldnt quit smoking, and it was very funny, Huang said. It was a spanish man decided when he was 113 to stop smoking because he was getting old, and he died two years later. This is why Anatoly wouldnt quit; He was very optimistic and funny.

Huang and Khitrin also hold two patents that Kent State is recognized for.

He was a very smart scientist, and one day I told him of this realization I had with Prussian blue pigment, Huang said. He and I tested this pigment to be used in MRIs instead of toxic metal Gadolinium, and we proved that it worked. Now we share a patent over this discovery.

Robert Twieg, a chemistry and biochemistry professor, knew Khitrin the entire time he worked for Kent State and said he was a friendly and intelligent man.

Khitrin was an expert on nuclear magnetic resonance spectroscopy, Twieg said. People may argue that he was the smartest man in the chemistry department. He understood the quantum universe better than anyone employed in our department. His intelligence and kindness will be missed.

Holli Phillips is the health and wellness reporter. Contact her at hphill10@kent.edu.

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Kent State chemistry department and patent-holding professor dies - Kent Wired

Cell Biology

‘Liquid scaffolding’: Watery droplets form structures inside cells – Princeton University

A research team led by Princeton engineers has revealed in remarkable new detail how liquid droplets can develop structure amidst the soup of material found inside a living cell. These droplets, known as membraneless organelles, play critical roles in cellular function and diseases.

The team, a mix of biologists and materials scientists, has shown that surprisingly low concentrations of proteins can readily condense into a droplet that has internal structure, yet is very dilute, consisting mostly of empty, watery space. This liquid scaffolding lets molecules only of certain sizes easily diffuse in and out of the structure, enabling them to perform their vital tasks.

The new insights into the molecular organization inside membraneless organelles will help clarify their contributions to health and when that organization breaks down to certain diseases.

In this study, we have measured important aspects of the protein-to-protein interactions that drive the form and function of a membraneless organelle, said Ming-Tzo Wei, a postdoctoral research associate in the Department of Chemical and Biological Engineering and lead author of the study published June 26 in the journal Nature Chemistry.

Were really starting to understand the molecular-level organization within this membraneless class of cellular structures, saidClifford Brangwynne, an assistant professor ofchemical and biological engineering, senior author of the paper and principal investigator of the Soft Living Matter Group.

At left: Membraneless organelles, called P granules, are shown in green around a cell's nucleus in a flatworm embryo. Middle: A zoom-in of the liquid-like organelles. At right: An artist's impression of a tighter zoom into the P granule, revealing its structure that it is permeable to molecules only of certain sizes, shown in red.

Image courtesy of the researchers

The team collaborated with Rohit Pappu, a biomedical engineer at Washington University in St. Louis, and also includedRodney Priestley, associate professor of chemical and biological engineering, andCraig Arnold, director of thePrinceton Institute for the Science and Technology of Materials.

The researchers focused on a protein type, LAF-1, that joins with other proteins and RNA to form a globular, membraneless organelle called a P granule. In a popularly studied roundworm,Caenorhabditis elegans, the P granules keep the worms sex cells in a prepared state for reproduction.

A set of experiments sought to determine the concentration of LAF-1 inside of a P granule versus the levels of the protein otherwise floating freely within the cell. Knowing the difference would tell the researchers what concentration of the protein is needed to form the structure. A novel technique, called ultrafast-scanning fluorescence correlation spectroscopy, proved critical to the task.

Developed in collaboration with paper co-author Arnold, who also is a professor of mechanical and aerospace engineering, the technique uses a special lens to reduce uncertainty about the size of a volume being scanned by a microscope. As a result, the concentration of proteins fitted with fluorescent tags can be accurately determined in a given space, for instance within a P granule.

Wei took a series of such measurements, along with co-first author Shana Elbaum-Garfinkle, also a postdoctoral research associate in the Department of Chemical and Biological Engineering. In addition, the researchers tracked the motions of molecules in the P granule and observed how interactions with RNA reduced the protein concentration, in effect lowering the granules fluid consistency, or viscosity.

For further insight, the researchers turned to the science of polymers, which are substances composed of many similar, smaller units, like those found in consumer plastic products. LAF-1 is a disordered protein, and can be thought of as a flexible polymer chain. The polymeric nature of LAF-1 allows it to form a scaffold-like network within the droplet. However, unlike with plastics, the teams results indicated that the mesh size, or average size of the gaps between units, is relatively large, three to eight nanometers (billionths of a meter). Molecules larger than this span cannot move throughout the droplet. This result places limits on the kinds of material that the membraneless organelle can interact with inside of a cell, shedding light on its function.

The findings were further validated by a series of computer simulations run by computational biophysicist and co-first author Alex Holehouse, a graduate student working closely with his adviser Pappu of Washington University in St. Louis.

We were able to basically swim inside the organelles to determine how much room is actually available," Pappu said in a news story published by Washington University. "While we expected to see a crowded swimming pool, we found one with plenty of room, and water. Were starting to realize that these droplets are not all going to be the same.

Pappu added that the implications for the work are broad. It is essential to be able to understand how one can regulate the functions of these droplets, Pappu said. If we succeed, the impact could be transformative: its not just cancer, its neurodegeneration, about developmental disorders, and even the fundamentals of cell biology.

The advance required the melding of multiple perspectives and expertise, Brangwynne said.

This study represents a unique collaboration between soft matter and polymer physics, mechanical engineering, computational physics and biology, said Brangwynne. Working together in this way has given us all a real sense of triumph in having helped move science forward.

Additional authors on the paper include Carlos Chih-Hsiung Chen, a research specialist in the Department of Chemical and Biological Engineering, and Marina Feric, formerly of Princeton and now a postdoctoral fellow at the National Institutes of Health. The work was supported by the Princeton Center for Complex Materials, the National Science Foundation, the National Institutes of Health and the Eric and Wendy Schmidt Transformative Technology Fund.

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'Liquid scaffolding': Watery droplets form structures inside cells - Princeton University

Cell Biology

Is sense of smell linked to being fatter or thinner? – CBS News

Would you be willing to give up the smell of fresh-baked chocolate chip cookies or a pizza right out of the oven if it meant slimming down?

A new study showed that mice that lost their sense of smell didn't gain weight even when they ate the same high-fat diet as mice that could smell and did gain weight.

The mice that retained their sense of smell packed on twice their normal weightwhile the smell-deficient mice didn't gain at all, scientists from the University of California, Berkeley, reported in the journal Cell Metabolism.

A group of mice whose olfactory neurons had been genetically altered to take away their sense of smell were also compared with another group of mice whose sense of smell had been enhanced. The "super-smellers" gained even more weight.

Two mice on the same high-fat diet are shown in the photo. The mouse on the top grew plump but the mouse on the bottom, whose sense of smell was blocked by UC Berkeley researchers, stayed a normal weight.

Andrew Dillin and Celine Riera, UC Berkeley

"This paper is one of the first studies that really shows if we manipulate olfactory inputs, we can actually alter how the brain perceives energy balance, and how the brain regulates energy balance," said study author Cline Riera.

The findings raise questions about whether or not the same would hold true for humans, Riera, a former UC Berkeley postdoctoral fellow now an assistant professor at Cedars-Sinai Medical Center in Los Angeles, told CBS News.

"The cool thing about olfactory nerves is that they are totally unique. They're not in brain, they're in the nose. Maybe in future, we can non-invasively block them in humans. Maybe if you can remove olfaction in the patients for several months, it may help them lose weight," she said.

In an article in Berkeley News, senior study author Andrew Dillin said, "Sensory systems play a role in metabolism. Weight gain isn't purely a measure of the calories taken in; it's also related to how those calories are perceived."

The researchers hope future work in this area could someday benefit patients who are morbidly obese or overweight people with health problems like diabetes.

Dillin, a professor of molecular and cell biology and Howard Hughes Medical Institute investigator, said that if the discovery proves true in humans as well as mice, it could offer new treatment options for obese patients thinking about stomach stapling or bariatric surgery. "For that small group of people, you could wipe out their smell for maybe six months and then let the olfactory neurons grow back, after they've got their metabolic program rewired," he suggested.

Those with food addictions, such as binge-eating disorders, might be helped, too.

Riera said, "We hope to eventually find a way to do that in humans as well, and help them control their addictive behaviors and switch their metabolism to fat burning instead of fat storage."

2017 CBS Interactive Inc. All Rights Reserved.

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Is sense of smell linked to being fatter or thinner? - CBS News

Genetics

Molecular Genetics – Genetics Conferences

Sessions/Tracks

Track 1:Molecular Biology

Molecular biologyis the study of molecular underpinnings of the processes ofreplication,transcription,translation, and cell function. Molecular biology concerns themolecularbasis ofbiologicalactivity between thebiomoleculesin various systems of acell,gene sequencingand this includes the interactions between theDNA,RNAand proteinsand theirbiosynthesis. Inmolecular biologythe researchers use specific techniques native to molecular biology, increasingly combine these techniques and ideas from thegeneticsandbiochemistry.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, Canada; 9th International Conference onGenomicsandPharmacogenomics, June 15-16, 2017 London, Uk; 6th International Conference and Exhibition onCellandGene Therapy, Mar 27-28, 2017 Madrid, Spain; Gordon Research Conference,Viruses&Cells, 14 - 19 May 2017, Lucca, Italy;Human Genome Meeting(HGM 2017), February 5-7 2017, Barcelona, Spain; Embl Conference:Mammalian GeneticsAndGenomics:From Molecular Mechanisms To Translational Applications, Heidelberg, Germany, October 24, 2017;GeneticandPhysiological Impacts of Transposable Elements, October 10, 2017, Heidelberg, Germany.

American Society for Cell Biology;The Society for Molecular Biology & Evolution;American Society for Biochemistry and Molecular Biology;The Nigerian Society of Biochemistry and Molecular Biology;Molecular Biology Association Search Form - CGAP.

Track 2:Gene Therapy and Genetic Engineering

Thegenetic engineeringis also called asgenetic modification. It is the direct manipulation of an organism'sofgenomeby usingbiotechnology. It is a set of technologies used to change the genetic makeup of the cell and including the transfer of genes across species boundaries to produce improved novelorganisms. Genesmay be removed, or "knocked out", using anuclease.Gene is targetinga different technique that useshomologousrecombinationto change anendogenous gene, and this can be used to delete a gene, removeexons, add a gene, or to introducegenetic mutations. There is an dna replacement therapy, Genetic engineering does not normally include traditional animal and plant breeding, gene sequencing, in vitro fertilization, induction of polyploidy,mutagenesisand cell fusion techniques that do not use recombinant nucleic acids or a genetically modified organism in the process,diseases treated with gene therapywas initially meant to introduce genes straight into human cells, focusing on diseases caused by single-gene defects, such as cystic fibrosis, hemophilia, muscular dystrophy and sickle cell anemia

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

8thWorld Congress onMolecular Pathology, June 26-27, 2017 San Diego, USA; 11thInternational Conference onSurgical Pathology& Practice, March 27-28, 2017, MADRID, SPAIN; 13th EuropeanPathologyCongress, Aug 02-03, 2017, MILAN, ITALY; 28th Annual Meeting, Austrian Society ForHuman GeneticsAnd The Swiss Society OfMedical GeneticsCombined Meeting 2017 march 29, 2017 - March 31, 2017, bochum , Germany.

Association for Clinical Genetic Science;Genetics Society of America | GSA;Association of Genetic Technologists;Molecular Genetics - Human Genetics Society of Australasia;Genetic Engineering - Ecological Farming Association.

Track 3:Cell & Gene Therapy

Cell therapy is also calledcellular therapyorCyto therapy, in which cellular material is injected into patient this generally means intact, living cells. The first category iscell therapyin mainstream medicine. This is the subject of intense research and the basis of potential therapeutic benefit. Such research can be controversial when it involves human embryonic material. The second category is in alternative medicine, and perpetuates the practice of injecting animal materials in an attempt to cure disease.Gene therapyis the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy is a way to fix agenetic problemat its source. The polymers are either translated into proteins, interfere with targetgene expression, or possibly correct genetic mutations. The most common form uses DNA that encodes a functional,therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a "vector", which carries the molecule inside cells. Vectors used in gene therapy, the vector incorporates genes intochromosomes. The expressed nucleases then knock out and replace genes in the chromosome. The Center forCell and Gene Therapyconducts research into numerous diseases, including but not limited to PediatricCancer, HIV gliomaandCardiovascular disease.

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2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, 27 Canada ; 7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand ; American Society ofGeneandCell Therapy(ASGCT) 20th Annual Meeting, 10 - 13 May 2017, Washington, DC;Genomic Medicine for Clinicians(course), January 25-27, 2017, Hinxton , Cambridge, UK; Embo Conference:ChromatinandEpigenetics, Heidelberg, Germany, May 3, 2017; 14th International Symposium on Variants in theGenomeSantiago de Compostela, Galicia, Spain, June 5 - 8, 2017;

Genetics and Molecular Medicine - American Medical Association;Genetics Society of America / Gsa;British Society for Genetic Medicine;British Society for Gene and Cell Therapy; Australasian Gene Therapy Society.

Track 4:Cell Cancer Immunotherapy

Immunologydeals with the biological and biochemical basis for the body's defense against germs such as bacteria, virus and mycosis (fungal infections) as well as foreign agents such asbiological toxinsand environmental pollutants, and failures and malfunctions of these defense mechanisms. Cancer immunotherapy is the use of the immune system to treat cancer. Immunotherapies can be categorized as active, passive or hybrid (active and passive). Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. The immune system normally uses them to fight pathogens. A type of biological therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection, and other diseases. Some types of immunotherapy only target certain cells of the immune system. Others affect the immune system in a general way. Types of immunotherapy include cytokines, vaccines, bacillus Calmette-Guerin (BCG), and some monoclonal antibodies.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

9thAnnual Meeting onImmunologyandImmunologist, July 03-05, 2017 Kuala Lumpur, Malaysia; 8th MolecularImmunology&ImmunogeneticsCongress, March 20-21, 2017 Rome, Italy; 8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; July 03-05, 2017; B Cells and T Follicular Helper Cells Controlling Long-Lived Immunity (D2), April 2017, 2327, Whistler, British Columbia, Canada; Mononuclear Phagocytes in Health,Immune Defense and Disease, 304 May, Austin, Texas, USA;Modeling Viral Infections and ImmunityMAY 2017, 14, Estes Park, Colorado, USA; IntegratingMetabolism and Immunity(E4)292 June, Dublin, Ireland.

The American Association of Immunologists;Clinical Immunology Society ; Indian Immunology Society;IUIS - International Union of Immunological Societies;American Society for Histocompatibility and Immunogenetics.

Track 5:Clinical Genetics

Clinical geneticsis the practice of clinical medicine with particular attention tothe hereditary disorders. Referrals are made togenetics clinicsfor the variety of reasons, includingbirth defects,developmental delay,autism,epilepsy, and many others. In the United States, physicians who practice clinical genetics are accredited by theAmerican Board of Medical Genetics and Genomics(ABMGG).In order to become a board-certified practitioner of a Clinical Genetics, a physician must complete minimum of 24 months of his training in a program accredited by the ABMGG. Individual seeking acceptance intoclinical geneticstraining programs and should hold an M.D. or D.O. degree (or their equivalent)and he/she have completed a minimum of 24 months of their training in ACGME-accredited residency program internal medicine, pediatrics and gynecology or other medical specialty.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

Belgian Society OfHuman GeneticsMeeting 2017 february 17, 2017, Belgium; American College Of Medical Genetics 2017 AnnualClinical GeneticsMeeting march 21-25 2017, phoenix , United States; German Society Of Human Genetics 28th Annual Meeting, Austrian Society ForHuman GeneticsAnd The Swiss Society OfMedical GeneticsCombined Meeting 2017 march 29, 2017 - March 31, 2017, bochum , Germany; Spanish Society OfHuman GeneticsCongress 2017april 25, 2017 - April 28, 2017 madrid , Spain;

Clinical Genetics Associates;Clinical Genetics Society(CGS);The genetic associate;International Conference on Clinical and Medical Genetics;Association for Clinical Genetic Science;The American Society of Human Genetics.

Track 6:Pharmacogenetics

Pharmacogeneticsis the study of inherited genetic differences in drug metabolic pathways which can affect individual responses towards the drugs, both in their terms of therapeutic effect as well as adverse effects. In oncology, Pharmacogenetics historically is the study ofgerm line mutations(e.g., single-nucleotide polymorphisms affecting genes coding forliver enzymesresponsible for drug deposition and pharmacokinetics), whereaspharmacogenomicsrefers tosomatic mutationsin tumoral DNA leading to alteration in drug response.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

Spanish Society OfHuman GeneticsCongress 2017april 25, 2017 - April 28, 2017, madrid , Spain; 8th World Congress onPharmacology, August 07-09, 2017 Paris, France; World Congress onBio therapeutics, May 22-23, 2017, Mexico City, Mexico; 8th World Congress OnPharmacologyAndToxicology, July 24-26, 2017, Melbourne, Australia; German Society Of Human Genetics 28th Annual Meeting, Austrian Society ForHuman GeneticsAnd The Swiss Society OfMedical GeneticsCombined Meeting 2017march 29, 2017 - March 31, 2017 bochum , Germany.

Pharmacogenomics - American Medical Association;Associate Principal Scientist Clinical Pharmacogenetics;European Society of Pharmacogenomics and Personalised Therapy;Genome-wide association studies in pharmacogenomics.

Track 7:Molecular Genetic Pathology

Molecular genetic pathologyis an emerging discipline withinthe pathologywhich is focused in the study and diagnosis of disease through examination of molecules within the organs, tissues or body fluids. A key consideration is more accurate diagnosis is possible when the diagnosis is based on both morphologic changes in tissuestraditional anatomic pathologyand onmolecular testing. Molecular Genetic Pathology is commonly used in diagnosis of cancer and infectious diseases. Integration of "molecular pathology" and "epidemiology" led tointerdisciplinaryfield, termed "molecular pathological epidemiology" (MPE),which representsintegrative molecular biologicand population health science.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

8th World Congress OnMolecular Pathology, June 26-27, 2017 San Diego, USA; 11th International Conference OnSurgical Pathology& Practice, March 27-28, 2017, Madrid, Spain; 13th EuropeanPathologyCongress, Aug 02-03, 2017, Milan, Italy; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; Embo|Embl Symposium: TheMobile Genome: Genetic And Physiological Impacts Of Transposable Elements, Heidelberg, Germany, October 10, 2017.

Clinical Pathology Associates Molecular Pathology; Association mapping Wikipedia;Association for Molecular Pathology(AMP);Molecular Pathology - Association of Clinical Pathologists;SELECTBIO - Molecular Pathology Association of India.

Track 8:Gene Mapping

Genomemappingis to place a collection of molecular markers onto their respective positions ongenome.Molecular markerscome in all forms. Genes can be viewed as one special type of genetic markers in construction ofgenome maps, and the map is mapped the same way as any other markers. The quality ofgenetic mapsis largely dependent upon the two factors, the number of genetic markers on the map and the size of themapping population. The two factors are interlinked, and as larger mapping population could increase the "resolution" of the maps and prevent the map being "saturated". Researchers begin a genetic map by collecting samples of blood or tissue from family members that carry a prominent disease or trait and family members that don't. Scientists then isolate DNA from the samples and closely examine it, looking for unique patterns in the DNA of the family members who do carry the disease that the DNA of those who don't carry the disease don't have. These unique molecular patterns in the DNA are referred to as polymorphisms, or markers.

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3rd WorldBio Summit&Expo, Abu Dhabi, UAE, June 19-21, 2017; 9th International Conference onGenomicsandPharmacogenomicsJune 15-16, 2017 London, Uk; Keystone Symposium: Mononuclear Phagocytes in Health,Immune DefenseandDisease, 304 May 2017, Austin, Texas, USA;Molecular Neurodegeneration(course) Hinxton, Cambridge, UK, January 9-14, 2017;

Association for Clinical Genetic Science;Genome-wide association study Wikipedia;Gene mapping by linkage and association analysis NCBI;Gene mapping by linkage and association analysis | Springer Link.

Track 9:ComputationalGenomics

Computational genomics refers to the use of computational and statistical analysis to decipherbiologyfromgenome sequencesand related data, including DNA and RNA sequence as well as other "post-genomic" data. This computational genomics is also known asComputational Genetics. These, in combination with computational and statistical approaches to understanding the function of the genes and statistical association analysis, this field is also often referred to as Computational and Statistical Genetics/genomics. As such, computational genomics may be regarded as a subset of bioinformatics and computational biology, but with a focus on using whole genomes rather than individual genes to understand the principles of how the DNA of a species controls its biology at the molecular level and beyond. With the current abundance of massive biological datasets, computational studies have become one of the most important means to biological discovery.The field is defined and includes foundations in thecomputer sciences,applied mathematics, animation, biochemistry, chemistry, biophysics,molecular genetics,neuroscienceandvisualization. Computational biology is different from biological computation, which is a subfield of computer engineering using bioengineering and biology to build computers, but is similar tobioinformatics.

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Modeling Viral Infections and Immunity,10. MAY 2017, 14, Estes Park, Colorado, USA;Integrating Metabolism and Immunity(E4)292 June, Dublin, Ireland; EMBL Conference:Mammalian GeneticsandGenomics, Heidelberg, Germany, October 24, 2017; EMBO|EMBL Symposium: The Mobile Genome:GeneticandPhysiological Impacts of Transposable Elements, Heidelberg, Germany, October 10, 2017;

American Association of Bio analysts - Molecular/Genetic Testing;ISCB - International Society for Computational Biology;International Society for Computational Biology Wikipedia;Bioinformatics societies OMICtools;Towards an Australian Bioinformatics Society.

Track 10:Molecular Biotechnology

Molecular Biotechnologyis the use of living systems and organisms to develop or to make products, or "any technological application that uses the biological systems, living organisms or derivatives, to make or modify products or processes for specific use. Molecular biotechnology results from the convergence of many areas of research, such as molecular biology, microbiology, biochemistry, immunology, genetics and cell biology. It is an exciting field fueled by the ability to transfer genetic information between organisms with the goal of understanding important biological processes or creating a useful product. The completion of the human genome project has opened a myriad of opportunities to create new medicines and treatments, as well as approaches to improve existing medicines. Molecular biotechnology is a rapidly changing and dynamic field. As the pace of advances accelerates, its influence will increase. The importance and impact of molecular biotechnology is being felt across the nation. Depending on the tools and applications, it often overlaps with the related fields of bioengineering,biomedical engineering, bio manufacturing andmolecular engineering.Biotechnologyalso writes on the pure biological sciences animalcell culture, biochemistry,cell biology, embryology, genetics, microbiology, andmolecular biology.

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8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; World Congress onBio therapeutics, May 22-23, 2017, Mexico City, Mexico;Human Genome Meeting(HGM 2017), February 5-7 2017, Barcelona, Spain;Integrating MetabolismandImmunity (E4), 292 June, Dublin, Ireland.

Biotech Associations - Stanford University;Indian Society of Genetics, Biotechnology Research & Development;Genetics and Molecular Medicine - American Medical Association;Genetics Society of America | GSA, British Society for Genetic Medicine;Heritability in the Era of Molecular Genetics - Association for Psychological science.

Track 11:Genetic Transformation

Genetic Transformationis the genetic alteration of cell resulting from the direct uptake and incorporation ofexogenous genetic materialfrom its surroundings through thecell membrane. Transformation is one of three processes for horizontal gene transfer, in which exogenous genetic material passes from bacterium to another, the other two being conjugation transfer of genetic material between two bacterial cells in direct contact andTransductioninjection offoreign DNAby a bacteriophage virus into thehost bacterium. And about 80 species of bacteria were known to be capable of transformation, in 2014, about evenly divided betweenGram-positiveandGram-negative Transformation" may also be used to describe the insertion of new genetic material into non-bacterial cells, including animal and plant cells.

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13th EuropeanPathologyCongress, Milan, Italy; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; Embo|Embl Symposium: TheMobile Genome: Genetic And Physiological Impacts Of Transposable Elements, Heidelberg, Germany, October 10, 2017; 2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, Canada; 9th International Conference onGenomicsandPharmacogenomics, June 15-16, 2017 London, Uk;

American Society of Gene & Cell Therapy: ASGCT;Gene Therapy Societies and Patient Organizations - Gene Therapy Net;European Society of Gene and Cell Therapy (ESGCT);British Society for Gene and Cell Therapy;Gene Therapy - American Medical Association.

Track 12:Genetic Screening

Genetic screenis an experimental technique used to identify and select the individuals who possess a phenotype of interest inmutagenized population. A genetic screen is a type ofphenotypic screen. Genetic screen can provide important information on gene function as well as the molecular events that underlie a biological process or pathway. While thegenome projectshave identified an extensive inventory of genes in many different organisms, genetic screens can provide valuable insight as to how thosegenes function.

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13th EuropeanPathologyCongress, Aug 02-03, 2017, Milan, Italy; 2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, 27 Canada; 7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; Embo|Embl Symposium: TheMobile Genome: Genetic And Physiological Impacts Of Transposable Elements, Heidelberg, Germany, October 10, 2017, 10 - 13 May 2017, American Society ofGeneandCell Therapy(ASGCT) 20th Annual Meeting, Washington, DC;

Association for Clinical Genetic Science; Association for Molecular Pathology (AMP);Mapping heritability and molecular genetic associations with cortical;Genetics and Molecular Medicine - American Medical Association.

Track 13:Regulation of Gene Expression

Regulation of Gene expressionincludes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA), and is informally termed gene regulation. Sophisticated programs of gene expression are widely observed in biology, Virtually any step of gene expression can be modulated, fromtranscriptional initiation,RNA processing, and post-translational modificationof a protein. Often, one gene regulator controls another in a gene regulatory network. Any step of gene expression may be modulated, from theDNA-RNA transcriptionstep to post-translational modification of a protein.

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7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand; EMBO|EMBL Symposium: The Mobile Genome:GeneticandPhysiological Impacts of Transposable Elements, Heidelberg, Germany, October 10, 2017; 10. MAY 2017, 14, Estes Park, Colorado, USA,Modeling Viral Infections and Immunity; 292 June, Dublin, Ireland,Integrating Metabolism and Immunity(E4); MAY 2017, 14, Estes Park, Colorado, USA,Modeling Viral InfectionsandImmunity; 8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; 9th International Conference onGenomicsandPharmacogenomics, June 15-16, 2017 London, Uk;

Gene Therapy Societies and Patient Organizations - Gene Therapy Net;European Society of Gene and Cell Therapy (ESGCT);British Society for Gene and Cell Therapy;Gene Therapy - American Medical Association

Track 14: Cancer Gene Therapy

Cancer is an abnormal growth of cells the proximate cause of which is an imbalance in cell proliferation and death breaking-through the normal physiological checks and balances system and the ultimate cause of which are one or more of a variety of gene alterations. These alterations can be structural, e.g., mutations, insertions, deletions, amplifications, fusions and translocations, or functional (heritable changes without changes in nucleotide sequence). No single genomic change is found in all cancers and multiple changes (heterogeneity) are commonly found in each cancer generally independent of histology. In healthy adults, the immune system may recognize and kill the cancer cells or allow non-detrimental host-cancer equilibrium; unfortunately, cancer cells can sometimes escape the immune system resulting in expansion and spread of these cancer cells leading to serious life threatening disease. Approaches to cancer gene therapy include three main strategies: the insertion of a normal gene into cancer cells to replace a mutated (or otherwise altered) gene, genetic modification to silence a mutated gene, and genetic approaches to directly kill the cancer cells. Pathway C represents immunotherapy using altered immune cells. Another unique immunotherapy strategy facilitated by gene therapy is to directly alter the patient's immune system in order to sensitize it to the cancer cells. One approach uses mononuclear circulating blood cells or bone marrow gathered from the patient.

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8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; World Congress onBio therapeutics, May 22-23, 2017, Mexico City, Mexico;Human Genome Meeting(HGM 2017), February 5-7 2017, Barcelona, Spain;Integrating MetabolismandImmunity (E4), 292 June, Dublin, Ireland.

Biotech Associations - Stanford University;Indian Society of Genetics, Biotechnology Research & Development;Genetics and Molecular Medicine - American Medical Association;Genetics Society of America | GSA, British Society for Genetic Medicine;Heritability in the Era of Molecular Genetics - Association for Psychological science.

Track 15:Genetic Transplantation

Transplantation genetics is the field of biology and medicine relating to the genes that govern the acceptance or rejection of a transplant. The most important genes deciding the fate of a transplanted cell, tissue, or organ belong to what is termed the MHC (the major histocompatibility complex). Genetic Transplantation is the moving of an organ from one body to another or from a donor site to another location on the person's own body, to replace the recipient's damaged or absent organ. Organs and/or tissues that aretransplantedwithin the same person's body are calledauto grafts. Transplants that are recently performed between two subjects of the same species are calledallografts. Allografts can either be from a living or cadaveric source Organs that can be transplanted are the heart, kidneys, liver, lungs, pancreas, intestine, and thymus. The kidneys are the most commonlytransplanted organs, followed by the liver and then the heart. The main function of the MHC antigens is peptide presentation to the immune system to help distinguish self from non-self. These antigens are called HLA (human leukocyte antigens). They consists of three regions: class I (HLA-A,B,Cw), class II (HLA-DR,DQ,DP) and class III (no HLA genes)

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8th World Congress onPharmacology, August 07-09, 2017 Paris, France; International Conference onClinicalandMolecular Genetics, Las Vegas, USA, April 24-26, 2017; Aug 02-03, 2017, 13th EuropeanPathologyCongress, Milan, Italy; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; 7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand.

American society of Transplantation;American Society of Transplant Surgeons: ASTS; Patient associations. Donation and transplantation;American Society of Gene & Cell Therapy ASGCT;Gene Therapy Societies and Patient Organizations - Gene Therapy Net.

Track 16:Cytogenetics

Cytogeneticsis a branch ofgeneticsthat is concerned withstudy of the structure and function of the cell, especially thechromosomes. It includes routine analysis of G-banded chromosomes, othercytogenetic banding techniques, as well as molecular Cytogenetics such as fluorescent in suitable hybridization FISH and comparativegenomic hybridization.

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9thAnnual Meeting onImmunologyandImmunologist, July 03-05, 2017 Kuala Lumpur, Malaysia; 8th MolecularImmunology&ImmunogeneticsCongress, March 20-21, 2017 Rome, Italy; 8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; July 03-05, 2017; B Cells and T Follicular Helper Cells Controlling Long-Lived Immunity (D2), April 2017, 2327, Whistler, British Columbia, Canada.

European Cytogeneticists Association;Association of Genetic Technologists;Association for Clinical Genetic Science;Cytogenetics - Human Genetics Society of Australasia;European Cytogeneticists Association

Molecular Biology 2016

Molecular Biology 2016 Report

2ndWorld Bio Summit & Molecular Biology Expowas organized during October 10-12, 2016 at Dubai, UAE. The conference was marked with the attendance ofEditorial Board Members of supporting journals, Scientists, young and brilliant researchers, business delegates and talented student communities representing more than 25 countries, who made this conference fruitful and productive.

This conference was based on the theme Recent advances in Bio Science which included the following scientific tracks:

Molecular Biology

Microbiology

Analytical Molecular Biology

Bioinformatics

Biochemistry and Molecular Biology

Molecular Biology and Biotechnology

Cancer Molecular Biology

Computational Biology

Molecular Biology of the Cell

Molecular biology of the cardiovascular system

Molecular Biology in Cellular Pathology

Molecular Biology of Diabetes

Molecular Biology and Genetic Engineering

Enzymology and Molecular Biology

Molecular Biology of the Gene

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Molecular Genetics - Genetics Conferences

Genetics

Genetics of Canine Personality Traits – The Bark (blog)

The influence of genes on personality and behavior is of great interest to people who love dogs as well as to scientists studying the genetics of animal behavior. Since dogs personalities play a major role in their ability to function as our companions as well as to carry out a variety of tasks as working dogs, its important to understand the contribution of genetics on behavior. It is well established that genetics plays a large role, as evidenced by behavioral differences between breeds. Even substantial differences in behavior within breeds can be accounted for by genetic variation.

One of the challenges to studying behavioral genetics is that large sample sizes are required because there are so many factors that influence behavior (e.g. early environment, training methods, various lifestyle factors). To achieve adequately large sample sizes in research is both expensive and time consuming, sometimes prohibitively so. A recent study called Genetic Characterization of Dog Personality Traits took a creative approach to meet this challenge.

The scientists were interested in genetic contributions to personality, defined as individual consistency in behavioral responsiveness to stimuli and situations. Researchers took advantage of the substantial knowledge people have about their own dogs personalities to explore genetic contributions to personality traits. Their work shows that it is possible to detect genetic variation in dog personality traits by using questionnaires to collect large quantities of useful data.

In this recent study, researchers used the C-BARQ (Canine Behavioral Assessment Research and Questionnaire) as well as a separate questionnaire about demographics to study 1975 UK Kennel Club-registered Labrador Retrievers. The C-BARQ allowed each dog to be scored for the following personality traitsAgitated When Ignored, Attention-Seeking, Barking Tendency, Excitability, Fetching, Fear of Humans and Objects, Fear of Noises, Non-Owner Directed Aggression, Owner-Directed Aggression, Separation Anxiety, Trainability and Unusual Behavior.

The additional questionnaire collected data about the dogs age, coat color, sex, neuter status, housing, health status, exercise, daily exercise and the role of the dog. (The various roles were gun dog, show dog and pet dog.) To gather genetic information, the study took advantage of the dogs pedigrees, which involved 29 generations and 28,943 dogs. Further genetic data on the dogs were obtained as part of a different study using standard genomic methods and genetic markers, with 885 dogs from that study also participating in the C-BARQ portion of the research. In the analysis, the researchers estimated heritability of personality traits based on both the pedigree and on the genomic data.

The researchers found that fetching has a higher heritability rating than any other personality trait. Interestingly, some previous studies have lumped trainability with fetching ability, which results in lower heritability scores for both of them. This study also revealed a considerable genetic component to the fear of noises. Aggression directed towards owners showed no genetic component at all, while aggression towards strangers had a moderate genetic component.

Many behavioral traits are polygenic (influenced by a large number of genes, with each one often having a small effect) and also have significant environmental influences, which means that it is difficult to determine genomic associations. Estimates of heritability are likely to increase with technological advances in genetic work.

The importance of this study is that it shows that genetic variance can be detected and studied with the use of questionnaires filled out by owners. It also reveals that grouping responses into behavioral factors may make it harder to detect the genetic influence on various traits.

Read more here:
Genetics of Canine Personality Traits - The Bark (blog)

Genetics

Genetics causing arthritis possibly helped humans survive Ice – Kasmir Monitor

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Genetics causing arthritis possibly helped humans survive Ice - Kasmir Monitor