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Donald Trump’s fishy behavior on Russia is bigger than possible email collusion – Vox

On June 18, 2013, when he was already well-known in political circles for his birther attacks on then-President Barack Obama, Donald Trump made an exciting announcement.

The Miss Universe Pageant will be broadcast live from MOSCOW, RUSSIA on November 9th, he tweeted. A big deal that will bring our countries together!

Doing business with Russia was in no way illegal at the time (this was before the invasion of Ukraine that triggered the current level of Western sanctions) and wasnt even particularly unusual. The stated aspiration that a tacky pageant would help bring the countries together was somewhat odd, especially given the then-overwhelming consensus in Republican Party circles that the Obama administration was too soft on Russia. But Trump is nothing if not a self-promoter, and pretending that his upcoming television special would have important diplomatic ramifications seems like a bit of harmless puffery.

But the follow-up tweet was genuinely weird.

Do you think Putin will be going to The Miss Universe Pageant in November in Moscow - if so, will he become my new best friend?

By this time, the Putin regime was already infamous for its crackdown on domestic dissent, brutal war in Chechnya, the murders of journalists Anna Politkovskaya and Paul Klebnikov at home and Alexander Litvinenko in London, and the ultimately failed poisoning of former Ukrainian leader Viktor Yushchenko.

That years State Department human rights report documented several reports that the government or its agents committed arbitrary or unlawful killings, while Human Rights Watch concluded that Russias cooperation with international institutions on human rights appears perfunctory.

Theres nothing particularly unusual about the United States enjoying cordial diplomatic or even business ties with authoritarian regimes that are also geopolitical allies. But Russia was not an ally of the United States, and Putin wasnt someone average Americans especially average Republicans tended to like. For Trump to express his desire for a friendly, personal relationship with the brutal and autocratic ruler of a hostile foreign country was odd.

But it proved to be the beginning of whats become, over the years, a signature element of Trumps thinking. Hes attached much more stubbornly than he is to any of his various heterodoxies on domestic policy to the idea of a Russia-friendly foreign policy that almost nobody else (including Republican lawmakers and key members of his own administration) believes in.

Thats the great mystery looming over all of the growing Trump/Russia scandals. Firmly disavowing Putin would be just about the lowest-hanging political fruit imaginable. Why wont Trump pluck it?

Soon after Election Day, it became clear that the question of Russian meddling in the 2016 election was going to be a substantial political problem for Trump. It also became clear that, as president, he was going to have to find a way to work with Republican Russia hawks in Congress and with an American military and intelligence community thats profoundly skeptical of Russia.

But before the election, he was considerably less restrained, and claimed to have a direct line to the Kremlin back in 2013, 2014, and even through much of 2015:

Later, of course, Trumps story changed. The current line from the president and his team is that any talk of him having anything to do with Russia is fake news and that he never met Putin before taking office. And, of course, Trump has lied about many things over the years. Its entirely possible that the year he spent insisting that hed been in contact with Putin and the broader Russian governing elite was just another example of Trump lying.

But its a strange thing to do. Stranger still is Trumps willingness to publicly defend Putins dismal human rights record.

Lots of American businessmen make money in countries with deplorable human rights records, and lots of American politicians are advocates for strategic alliances and commercial ties with countries that have deplorable human rights records.

But while overlooking abuses is common, its fairly unusual to straightforwardly deny them and especially to do so in a situation where there isnt any clear political, business, or strategic rationale for doing so. But Trump spent a good deal of time acting as a Putin spokesperson in the American press:

The eagerness to make excuses for Putins conduct seemed linked, rhetorically, to a somewhat half-baked notion that under Trump the United States and Russia would enjoy warmer relations.

There's nothing I can think of that I'd rather do than have Russia friendly, he said in a July 27, 2016, news conference. As opposed to the way they are right now, so that we can go and knock out ISIS with other people.

Later that day at a campaign rally, Trump said, wouldnt it be a great thing if we could get along with Putin? During the October 9 presidential debate, Trump returned to the theme that I think it would be great if we got along with Russia because we could fight ISIS together, as an example.

Shortly before Inauguration Day, on January 11, 2017, Trump said, If Putin likes Donald Trump, I consider that an asset, not a liability, because we have a horrible relationship with Russia. Russia can help us fight ISIS.

Trumps early personnel and policy moves matched up with this desire.

He quickly tapped retired Lt. Gen. Michael Flynn, known as an outlier among American military and intelligence professionals for his pro-Russian views, to serve as his national security adviser. And he bypassed the entire range of conventionally qualified candidates to serve as secretary of state in favor of Exxon executive Rex Tillerson, a former recipient of Russias Order of Friendship award. Early in his administration, Trump aimed to relax sanctions on Russia, only to back down in the face of congressional opposition.

In the end, Trumps Russia policy has landed in a more conventional place than these early moves would have suggested. Tillerson toed the standard American foreign policy line during his confirmation hearings, Defense Secretary James Mattis is a very normal Republican Russia hawk, and Flynn got fired and replaced with the much more widely respected Lt. Gen. H.R. McMaster as national security adviser.

But Trump himself has acted in many ways like an outsider to his own administrations Russia policy. But while hes simply detached from the details on many issues, he has pushed back forcefully against both Congress and his own advisers repeatedly on Russian matters.

This oddness begins with simply the way that Trump talks about Putin.

Obama called him a thug. So did Mitt Romney. Paul Ryan called him a devious thug. Marco Rubio called him both a thug and a gangster.

Trump fairly consistently declines to adopt this conventional language among American politicians, and he does so even though he is clearly aware at this point and has been for some time that suspicions about the nature of his relationship with the Russian government are a key point of political vulnerability. It would be the easiest thing on the planet for Trump to have his communications team draw up some standard-issue US-politician Putin-bashing rhetoric hes a thug, he murders journalists, he invades his neighbors and at a minimum assure Republican Party foreign policy elites that hes now down with the program.

After all, Trump used to espouse very unconventional views on things like tax cuts for the rich, Medicaid, and the importance of establishing universal health insurance coverage.

But in order to consolidate his position as leader of the GOP, Trump has dropped those ideologically heterodox views even though the heterodox position was more popular. On Russia, however, he insists on flying in the face of bipartisan consensus.

Watch: Trump is asked if he believes Russia interfered in our election, instead attacks Obama and the media. https://t.co/IrfviRPwru

Hes reluctant to even acknowledge that Russian hacking took place, resorting even to ridiculous lies about G20 conversations to change the subject.

Everyone here is talking about why John Podesta refused to give the DNC server to the FBI and the CIA. Disgraceful!

Perhaps most shockingly, Trumps own team of advisers had to drag him kicking and screaming into affirming Americas commitment to upholding Article V of the North Atlantic Treaty. And he did it only after humiliating those very same advisers by letting them brief the media that an affirmation was coming, only to cut it on the fly from the prepared text of his speech.

It was a bizarre thing to do, it clearly benefitted Russian foreign policy objectives, and it offered nothing but political downside for Trump.

The intersection of politics and law is a funny thing.

Politicized investigations into potential presidential scandals often end up turning on charges of perjury, obstruction of justice, making false statements to investigators, and other fine-grained ways in which people can get legally tripped up when theyre trying to cover embarrassing information. The much-discussed possibility of collusion with Russian election hacking is both vaguely defined, unproven at this point, and even if it happened may not have involved the president personally in any way.

These things end up hinging on small details, and the small details can be crucially important.

But the big picture also matters, and the big picture here is that Trump remains stubbornly unwilling to break with Putin and the Kremlin. The president used to regularly brag about his contacts with the leaders of the Russian government. The president won the election with the helping hand of the Russian government. The president repeatedly expressed his desire to change US foreign policy in a more pro-Russian direction. And though the president has, so far, been largely stymied in his efforts to do this seems to be straining against constraints imposed by the leadership of his own party and his own foreign policy team.

Perhaps Trump was lying about the contacts, ignorant about the campaign proposals, and his current attitudes reflect nothing more than bull-headedness.

Certainly thats what his Republican collaborators on the Hill seem to be telling themselves even as the White House works to get House Republicans to block a Russia sanctions bill that passed the Senate with 97 votes. But the mystery remains. Trump has been willing to reverse himself on other policy issues, gets no political benefit from pursuing such a pro-Russian course in the face of bipartisan opposition, and could score easy points by doing a little formulaic Putin-bashing. The fact that he refuses to tells you a lot about why Trumps presidency remains mired in scandal and why the worst may still be to come.

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Donald Trump's fishy behavior on Russia is bigger than possible email collusion - Vox

Johnson County students make dean’s list – The Daily Star-Journal

Columbia Johnson County students are named to the College of Agriculture, Food and Natural Resources deans list at the University of Missouri.

Harrison Bron, food science and nutrition, and Jared Yates, biochemistry, both of Knob Noster; and Emma Downing, agricultural economics, and Matthew Lichte, biochemistry, both of Warrensburg, made the list.

Being named to the deans list is an exceptional academic accomplishment,"Bryan Garton, associate dean and director of academic programs, said in a statement. "We are very proud of each student, not only for their academic excellence, but also for the hard work and dedication to their academics and career preparation this past semester.

Students must maintain a term GPA of 3.3, a cumulative GPA of 3.0 and be enrolled in a minimum of 12 credit hours to be named on the CAFNR deans list.

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Johnson County students make dean's list - The Daily Star-Journal

Ursinus gets biochemistry grant from National Science foundation – The Phoenix

COLLEGEVILLE >> U.S. Rep. Ryan Costello, R-6th Dist., visited Ursinus College on July 6 to announce a National Science Foundation grant.

The grant was in the amount of $28,531 for the project, Collaborative Research, which is researching using protein function prediction to promote hypothesis-driven thinking in undergraduate biochemistry education.

Costello, a member of the STEM Caucus, had the opportunity to meet with Rebecca Roberts, an associate professor of biology, and biochemistry and molecular biology at Ursinus College, as well as several students to hear about their research projects.

Im pleased to see students in our community will benefit from a grant that will enable first-hand experiences to encourage them to think like a scientist and, in turn, explore opportunities in STEM education. This grant will also help faculty understand how students learn from these techniques, Costello said in a prepared release.

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I am aiming to provide even greater opportunities for Ursinus students to experience authentic research by bringing research into their courses. As part of a collaboration with faculty from across the country, I have helped develop a project that challenges students to discover functions for proteins of known structure but with currently unknown function. This grant from the National Science Foundation will allow us to continue to engage our students in this project and to evaluate the impact of the experience on their growth as scientists, said Roberts.

Costello recently signed a bipartisan letter to the House Appropriations Committee requesting robust, continued funding for the NSF in the upcoming 2018 Fiscal Year, and has introduced and supported several pieces of legislation to support students who choose STEM fields.

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Ursinus gets biochemistry grant from National Science foundation - The Phoenix

Applying neuroscience to Cannes-winning work: Airbnb’s Until We All Belong – AdNews

'Until We All Belong' marks the most public corporate declaration for marriage equality in Australia to date.

AdNews has partnered with Neuro-Insight to bring an analysis of some of this year's winning Cannes work to understand what it is that made them successful through a neuroscience lens.

Companies have begun taking a serious stance on same-sex marriage. While the Australian government is yet to make a decision, brands are definitely rallying the cause. Following the launch of Airbnb'sUntil We All Belong, which centres on a unfinished ring that symbolises the gap in marriage equality, the analysts and Neuro-Insight wanted to find out what the public think about the initiative.

Airbnb - Until We All Belong

Clemenger BBDO have had a stellar year at Cannes taking out the coveted Agency of the Year award in conjunction with winning a grand total of 56 Lions across a number of different categories. Amongst that silverware, Clemenger picked up a silver lion in the Media category & a bronze lion in Design category for the marriage equality themed campaign they produced for the online booking service, Airbnb. Featuring several different people, firstly describing what appears to be a broken black ring, who then broach the issue of marriage equality, the spot adds a human element to what has, at least in this country, become a highly politicised and divisive public debate. There is no denying that this is a very powerful and emotive piece of storytelling that Clemenger has created, but what measurable impact does this spot leave with the viewer? As part of our exclusive Cannes on the Brain series, now in its sixth year, we analysed the brain activity of typical viewers to understand the impact that Clemengers creativity had on the brain.

How we did it

Neuro-Insight measured brain activity to see how 50 females and 50 males respond to the ad. The specific technology used by Neuro-Insight is founded in work originally developed for academic and neuroscience research, and has been used to analyse the effectiveness of Cannes award winners for over four years. The technology allows us to simultaneously record viewers second-by-second changes in approach (like)/withdraw (dislike), emotional intensity, engagement and memory whilst watching advertisements. The measure Neuro-Insight predominantly focusses on, is based on its strong and highly researched link in influencing consumer behaviours is long-term memory encoding. This measure reveals what the brain is storing (or encoding) into conscious and unconscious long-term memory. Neuro-Insights Memory Encoding graph reveals how elements of the ad are stored in long-term memory. The higher the graph, the more strongly that moment in the ad is stored in memory and the more likely it will influence consumer behaviour

Time Series

Below are the times series graphs for both male and female viewers responses to the Airbnb commercial. The red trace reflects memory encoding from the left hemisphere, which is primarily responsible for the encoding of the detail in experiences, such as text or dialogue. In contrast, the right hemisphere which is reflected by the blue line is concerned with the storing of global features, such as soundtracks, scenery, facial expressions as well as the emotional underpinnings of a particular experience.

Long term memory encoding for Female Viewers

Long term memory encoding for Male Viewers

The creative starts by featuring several different people who attempt to describe the symbolism of a broken ring. As the narrative flows from one talent to the next, we start to see differences emerge between male and female viewers, the most notable of which occurs the average level of memory encoding itself. During this narrative sequence, the level of memory encoding in female viewers is much higher than that of male viewers and closely tracks each new talent and their personal description of what a broken ring symbolises. In contrast, the response of male viewers is reduced, sitting largely within the moderate range of brain activity and does not show any initial preference for talent or message. It is not until the narrative links the missing gap in the ring as missing acceptance that we see a sharp retrigger in memory encoding for male viewers, which results in following visuals of the couple and their message of a disconnect being very strongly encoded.

The second half of the advertisement also follows a similar trend, with female viewers continuing to elicit generally higher levels of memory encoding to each new talent and their personal stories. However, our data does reveal that both genders responded strongly to key message of the gap needing to be closed. In females, this is met with an exceptionally high memory encoding response, whereas in male viewers, although not as strongly encoded, the response did retrigger and drive an increase in memory encoding. As the narrative transitions into the personal pledges and notwithstanding the lower memory encoding response in male viewers, the levels of engagement and emotional intensity increased, indicating that the narrative was eliciting a strong emotional impact in both groups. This contrasted with the first half of the advertisement, where the levels of engagement and emotion experienced by both groups was lower.

In the lead up to final branding, we see a brief interval of Conceptual Closure that effects the Until we all belong tagline screen in both genders. Conceptual Closure occurs when the brain perceives an event boundary, such as a narrative sequence has coming to an end and takes a brief period to process and store the previous experience. In this case, it is the combination of shortened pledges and fading soundtrack which is likely to have driven this effect. Importantly, the introduction of a voiceover call to action was powerful enough to retrigger and sustain memory encoding through to final branding in both genders.

In summary, Clemengers advertisement is a powerful piece of creative storytelling, that elicits different responses in male and female viewers alike. Female viewers stay with the entire piece, strongly encoding the personal journeys and brand message. In contrast, male viewers tend to encode the most pertinent message points rather than the general narrative. Therefore, if any cut-downs were produced, it would be recommended to consider using the specific talent and messaging that spoke to missing acceptance and closing the gap as these two scenes were either very strongly encoded or triggered a strong memory encoding response in both genders. In all, the main contention of the advertisement is well encoded within the URL call to action and final branding frame, which we feel, also makes this a very effective piece of advertising.

Have something to say on this? Share your views in the comments section below. Or if you have a news story or tip-off, drop us a line at adnews@yaffa.com.au

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Applying neuroscience to Cannes-winning work: Airbnb's Until We All Belong - AdNews

Neuroscience Is a Modern Tradition at Amherst College – Collegenews.org

AMHERST, Mass., Nov.13, 2006(AScribe Newswire) The number of undergraduate college students taking up neuroscience is large and growing, according to the Association of Neuroscience Departments and Programs (ANDP), which estimates that 5,000 people now graduate every year with a major in this academically demanding and intellectually exciting field. The first recorded use of the word neuroscience to mean comprising the sciences of brain and behavior was in Nature in 1970, the same year the Society for Neuroscience was founded. With extraordinary speed, Amherst College became the first institution in the United States to offer an undergraduate major in the new science, in 1973, at a time when miracles such as targeted medication for clinical depression or brain implants to alleviate human blindness were the stuff of science fiction.

At that time Stephen George, now the Manwell Family Professor in Life Sciences (Biology and Neuroscience), was brought to Amherst as an assistant professor of biology to work in the neuroscience program. To understand the nervous system, he said then, you have to understand its function on all levels. Thirty years later, hes still asking these questions: How does the mind work? How can we explain the behavior of animals and people? What goes wrong when someone is mentally ill or emotionally disturbed? Neuroscience is the modern attempt to answer these questions through the study of the brain-and in 2006 we enjoy a vastly greater physical understanding of the brain.

James Olds, a 1978 graduate of Amherst, and the director of the Krasnow Institute for Advanced Study and Krasnow University Professor of Computational Neuroscience at George Mason University, describes the changes in neuroscience. Our animal model in 1973 was the rat, he says of laboratory research into the human brain. In 2006, its the college sophomore.

Neuroscience at Amherst grew out of the biophysics major of the 50s and 60s, which produced some distinguished neuroscientists, in a field that had not yet been named. In 1970 the Alfred P. Sloan Foundation decided to support the new field of neuroscience at all levels. A proposal for an undergraduate program in neuroscience from Amherst received $400,000. The program first offered a neuroscience major in 1973. Undergraduate neuroscience programs are now quite common, as shown by the active Faculty for Undergraduate Neuroscience group associated with the Society for Neuroscience. Stephen George was among the founders of this organization, and Sarah M. Turgeon, an associate professor of psychology at Amherst, has served on its executive council.

The ANDP notes in its most recent annual report that the existence of undergraduate programs in neuroscience is a relatively recent phenomenon. The ANDP counts 33 undergraduate program members, but only two programs were founded before 1980, six programs between 1980 and 1989 and the rest only after 1989.

Perhaps because of its origin in biophysics, neuroscience at Amherst College is a demanding discipline. One student guide noted wryly that neuro is the major to avoid if you want to take the country-club approach to college. Yet many choose it. Almost from the beginning the neuroscience department has attracted a dozen or more majors in every class. Mirroring the national trend, the numbers are growing.

Several fields of science, including biology, chemistry, psychology, mathematics, computer science and physics, are important in studying the nervous system, and Amherst students who major in neuroscience take courses in all of these fields. The courses include laboratory work emphasizing modern techniques, such as recording electrical activity from single nerve cells, measuring behavioral effects of drugs and working with proteins and nucleic acids. The neuroscience major consists of 14 courses, more courses than required for any other major at Amherst. Neuroscience majors also take part in the Neuroscience Seminar, in which Amherst students and faculty discuss current research and through which guest neuroscientists visit to lecture on their work. This fall, the seminar heard a 1980 Amherst graduate, Neal Swerdlow of the UCSD Medical School, discuss Neuropsychiatric Disorders of Impaired Central Inhibition: Things Weve Learned in the Blink of an Eye.

Neuroscience at Amherst offers senior students opportunities for honors thesis research projects. Usually based in the research areas of the neuroscience faculty, these projects have delved into the neurophysiology of the visual system, control of neural excitability, developmental psychobiology, animal models of schizophrenia and the neural basis of feeding behavior.

Amherst students have frequently been able to present the results of their research at the national meetings of the Society for Neuroscience or the Biophysical Society. For example, Tiffany Lin, a 2006 graduate, recently received a competitive Travel Award from the Faculty for Undergraduate Neuroscience, which took her to Atlanta for the annual meeting of the Society for Neuroscience. Lins presentation, Repeated exposure to PCP alters stress-induced behavior and striatal c-Fos, described the results of her research as an undergraduate working with Turgeon in the psychology department.

Lin is now at the behavioral genetics laboratory at the Mailman Research Institute at McLean Hospital in Boston, where shes working on the mechanisms of neurogenesis. Most Amherst neuroscience majors enter graduate or professional programs, either right after graduation or after working or traveling for a time. Their careers may involve medicine, research, teaching or a combination of these. They are doing research in laboratories at the National Institutes of Health, teaching high school in Boston, practicing medicine around the country or working in the business world in a biomedical field. They all maintain their keen fascination with how the brain works, sharpened by the rigors of neuroscience at Amherst College.

CONTACTS: Stephen George, Amherst College, 413-542-2477

James Olds 78, George Mason University, 703-993-4378

Tiffany Lin 06, McLean Hospital, 617-855-2009

Sarah Turgeon, Amherst College, 413-542-2625

Paul Statt, Amherst College Media Relations, 413-542-8417

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Neuroscience Is a Modern Tradition at Amherst College - Collegenews.org

India lags in clinical research field: Dr Mishra – Times of India

Nagpur: Even as the health care system has seen rapid advancements over the years, the country has witnessed minuscule progress in the field of research in physiology. This is evident from the fact that in the year 2014-15, total 43,689 publications came out from all 421 medical colleges of the country, including eight premier institutions. The contribution of the department of physiology was, however, just 0.82%.

Revealing these figures, chancellor of Krishna Institute of Medical Sciences Deemed University, Dr Ved Prakash Mishra, rued the fact that the field of physiology hasn't grown much in the country.

Mishra also talked about the poor research work being carried out in private clinics. "If we talk about our country's private clinical set-ups, the conversion of their clinical work into research material is mere 4.2%, while in a small country like Poland their utilization is 92%. In the US, their utilization rate is 72%, while even China manages it to an extent of 52%."

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India lags in clinical research field: Dr Mishra - Times of India

Nanoscale forces measured in aortic smooth muscle cells tell story … – Phys.Org

July 10, 2017 Nanonet Force Microscropy (NFM) can measure the contractile inside-out forces of a single cell attached to multiple fibers. Shown here are f-actin (red), paxillin (green), and the nucleus (blue). Scale bar = 20 micron. Credit: Abinash Padhi, STEP Lab, Virginia Tech

Researchers from Virginia Tech and the University of Pittsburgh have collaborated to employ a novel nanoscale fibrous system that can measure the tiny forces exerted by and upon individual cells with extreme precision. The team hopes that this platform, which investigators call nanonet force microscopy (NFM), will provide new knowledge about smooth muscle cell biology that could have implications for treating cardiovascular disease, which is still a leading cause of death in the United States.

The results of investigations on cells using this platform appear in the "Forces" issue of the journal Molecular Biology of the Cell, in the article "Nanonet Force Microscopy for Measuring Forces in Single Smooth Muscle Cells of Human Aorta," published July 7, 2017.

The main goal of this current study, said Julie Phillippi, assistant professor at the University of Pittsburgh Department of Cardiothoracic Surgery whose laboratory provided healthy human patient smooth muscle cells for the study, was to quantify forces that healthy cells experience in various conditions of stress. The fibrous nanonet itself was designed in the mechanical engineering laboratory of Amrinder Nain, associate professor at Virginia Tech and member of the American Society for Cell Biology. Forces measured using NFM, Nain said, include forces exerted by the cells themselves and forces exerted by the environment on the cells. "Everything in nature exerts and experiences a physical force," said Nain. "This platform measures both simultaneously."

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Phillippi said that previous work tested the mechanical strength of whole aortic tissue and understanding the single cell biomechanics is vitally important. Single-cell studies provide insight into the proteins involved in the fleeting so-called focal adhesions that most cells make as they move around their microenvironment. The NFM assembly aims to mimic, in as physiologically relevant a way as possible, what cells endure within the collagen fibers of the extracellular matrix (ECM)the matrix that supports cell growth in living things. Tweaking the artificial matrix by changing fiber diameter, density, and spacing in a controlled and repeatable manner, as well as using cells from diseased patients at different disease severities, will allow Phillippi and Nain to simulate the conditions experienced by cells in many realistic situations.

"We have looked very closely at how the collagen and elastin fibers in the ECM are arranged and the micro-architecture and everything points to these microstructural defects in the ECM contributing to the weakening of the aortic walls and the ballooning of the vessel," said Phillippi. "What we don't know is, are these ECM proteins arranged that way from birth or is it something that happens over time? Or is it both? What role do the cells play? This engineered platform will allow us to answer some of those questions." Furthermore, Nain said, NFM could reveal the heterogeneity of cells taken from the same patient or from different patients with the same disease state down to the single-cell resolution.

Next steps for Phillippi and Nain include testing cells from the Pittsburgh team's large repository of aortic specimens from patients, collected in collaboration with Thomas Gleason, Chief of the Division of Cardiac Surgery, University of Pittsburgh, to establish a database of baseline forces for many types of cells that researchers and clinicians can use to diagnose and treat disease. "The platform gives us the ability to create in vitro disease models with multiple layers of sophistication," said Phillippi.

In a broader context, the ability to achieve precise control on fiber diameter, spacing, and orientation to mimic native fibrous environments, will allow NFM to interrogate the push and pulls in a cell's journey in developmental, disease, and repair biology.

Explore further: Cancer cells 'talk' to their environment, and it talks back

More information: Alexander Hall et al. Nanonet force microscopy for measuring forces in single smooth muscle cells of the human aorta, Molecular Biology of the Cell (2017). DOI: 10.1091/mbc.E17-01-0053

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Nanoscale forces measured in aortic smooth muscle cells tell story ... - Phys.Org

Memphis Researchers Planning Big Upgrades to Online Genetics Database – Memphis Daily News

VOL. 132 | NO. 135 | Monday, July 10, 2017

A pair of scientists in Memphis is using almost $2 million in grant money to make improvements to an online database and open-source software system called GeneNetwork, used by researchers to study genetic differences and evaluate disease risk.

Drs. Robert Williams and Saunak Sen, both part of the faculty at the University of Tennessee Health Science Center, won a grant from the National Institutes of Health for the project. GeneNetwork was launched in 2001 as part of a NIH Human Brain Project grant to UTHSC and was one of the first websites designed for gene mapping.

Williams, who chairs the Department of Genetics, Genomics and Informatics at UTHSC, said the grant money will be used to support major upgrades for the software infrastructure for gene mapping and analysis for the system. One of the systems main uses, he said, is being able to predict more accurate health outcomes from genetic and environmental data.

The system itself is like a combination of Microsofts popular Excel spreadsheet software paired with large amounts of financial data. Except in this case, its biological rather than financial data, combined with a sophisticated spreadsheet that allows users to perform their analyses.

Those users include undergraduate, graduate and postdoctoral students. The biggest slice of users is scientists, Williams said, who are interested in understanding the relationship between genetic differences and health status.

The grant has four major aims that will be stretched out over four years, Williams said. The first is to make this more useful to a larger community of users. Getting data in and out of GeneNetwork is quite a bit of work, so were going to be building some software that allows easier data entry into GeneNetwork.

The team at UTHSC which is where the GeneNetwork hub exists also wants to make some statistical improvements to the system. Theyll also be developing new analytical methods as well as tools so that the system is accessible not only to students and scientists but also professional statisticians, computer scientists and users at big pharmaceutical companies who Williams said need a different type of interface than what exists now.

The team supporting GeneNetwork actually extends beyond Memphis, spanning the globe, in fact. Other key members include Dr. Pjotr Prins, a computer programmer based in the Netherlands whos responsible for the software architecture. Dr. Karl Broman, a statistical geneticist from the University of Wisconsin-Madison, is also contributing to the project. And at UTHSC, Dr. Yan Cui, a computational biologist in the Department of Microbiology, Immunology and Biochemistry, is also working on the project.

According to Dr. Sen, GeneNetwork will facilitate reproducible research because of the way it gives researchers open access to both the data and the software code used to process it. Reproducibility, he said, is essential to the scientific method, and were proud to be part of the open science movement.

The second generation of the service, called GeneNetwork 2, can be accessed at http://gn2.genenetwork.org/.

There are exponentially growing databases on humans and mice and rats and plants, Williams said. And its really difficult to handle all those huge data sets. So what we need are online tools for analyzing and integrating those data sets, and GeneNetwork is a tool for doing just that.

It provides access to a lot of data sets and the genotypes of subjects, and it allows you to analyze what the relationship is between genetic differences and outcome measurements. Like, how much do you weigh, are you likely to have diabetes, how long will you live, things like that.

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BRIEF-Newlink Genetics receives notice of allowance from USPTO … – Reuters

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Genetics: The Study of Heredity – Live Science

A chart shows the dominant and recessive traits inherited in successive generations of guinea pigs.

Genetics is the study of how heritable traits are transmitted from parents to offspring. Humans have long observed that traits tend to be similar in families. It wasnt until the mid-nineteenth century that larger implications of genetic inheritance began to be studied scientifically.

Natural selection

This is one of the last photographs taken of Charles Darwin, who developed the theory of evolution whereby changes in species are driven, over time, by natural and sexual selection.

In 1858, Charles Darwin and Alfred Russell Wallace jointly announced their theory of natural selection. According to Darwins observations, in nearly all populations individuals tend to produce far more offspring than are needed to replace the parents. If every individual born were to live and reproduce still more offspring, the population would collapse. Overpopulation leads to competition for resources.

Darwin observed that it is very rare for any two individuals to be exactly alike. He reasoned that these natural variations among individuals lead to natural selection. Individuals born with variations that confer an advantage in obtaining resources or mates have greater chances of reproducing offspring who would inherit the favorable variations. Individuals with different variations might be less likely to reproduce.

Darwin was convinced that natural selection explained how natural variations could lead to new traits in a population, or even new species. While he had observed the variations existent in every population, he was unable to explain how those variations came about. Darwin was unaware of the work being done by a quiet monk named Gregor Mendel.

Inheritance of traits

In 1866, Gregor Mendel published the results of years of experimentation in breeding pea plants. He showed that both parents must pass discrete physical factors which transmit information about their traits to their offspring at conception. An individual inherits one such unit for a trait from each parent. Mendel's principle of dominance explained that most traits are not a blend of the fathers traits and those of the mother as was commonly thought. Instead, when an offspring inherits a factor for opposing forms of the same trait, the dominant form of that trait will be apparent in that individual. The factor for the recessive trait, while not apparent, is still part of the individuals genetic makeup and may be passed to offspring.

Mendels experiments demonstrated that when sex cells are formed, the factors for each trait that an individual inherits from its parents are separated into different sex cells. When the sex cells unite at conception the resulting offspring will have at least two factors (alleles) for each trait. One inherited factor from the mother and one from the father. Mendel used the laws of probability to demonstrate that when the sex cells are formed, it is a matter of chance as to which factor for a given trait is incorporated into a particular sperm or egg.

We now know that simple dominance does not explain all traits. In cases of co-dominance, both forms of the trait are equally expressed. Incomplete dominance results in a blending of traits. In cases of multiple alleles, there are more than just two possible ways a given gene can be expressed. We also now know that most expressed traits, such as the many variations in human skin color, are influenced by many genes all acting on the same apparent trait. In addition, each gene that acts on the trait may have multiple alleles. Environmental factors can also interact with genetic information to supply even more variation. Thus sexual reproduction is the biggest contributor to genetic variation among individuals of a species.

Twentieth-century scientists came to understand that combining the ideas of genetics and natural selection could lead to enormous strides in understanding the variety of organisms that inhabit our earth.

Mutation

Historically, scientists have defined living creatures by the presence of DNA, but how living creatures process information may be a better hallmark of life, a new study argues

Scientists realized that the molecular makeup of genes must include a way for genetic information to be copied efficiently. Each cell of a living organism requires instructions on how and when to build the proteins that are the basic building blocks of body structures and the workhorses responsible for every chemical reaction necessary for life. In 1958, when James Watson and Francis Crick described the structure of the DNA molecule, this chemical structure explained how cells use the information from the DNA stored in the cells nucleus to build proteins. Each time cells divide to form new cells, this vast chemical library must be copied so that the daughter cells have the information required to function. Inevitably, each time the DNA is copied, there are minute changes. Most such changes are caught and repaired immediately. However, if the alteration is not repaired the change may result in an altered protein. Altered proteins may not function normally. Genetic disorders are conditions that result when malfunctioning proteins adversely affect the organism. [Gallery: Images of DNA Structures]

In very rare cases the altered protein may function better than the original or result in a trait that confers a survival advantage. Such beneficial mutations are one source of genetic variation.

Gene flow

Another source of genetic variation is gene flow, the introduction of new alleles to a population. Commonly, this is due to simple migration. New individuals of the same species enter a population. Environmental conditions in their previous home may have favored different forms of traits, for example, lighter colored fur. Alleles for these traits would be different from the alleles present in the host population. When the newcomers interbreed with the host population, they introduce new forms of the genes responsible for traits. Favorable alleles may spread through the population. [Countdown: Genetics by the Numbers 10 Tantalizing Tales]

Genetic drift

Genetic drift is a change in allele frequency that is random rather than being driven by selection pressures. Remember from Mendel that alleles are sorted randomly into sex cells. It could just happen that both parents contribute the same allele for a given trait to all of their offspring. When the offspring reproduce they can only transmit the one form of the trait that they inherited from their parents. Genetic drift can cause large changes in a population in only a few generations especially if the population is very small. Genetic drift tends to reduce genetic variation in a population. In a population without genetic diversity there is a greater chance that environmental change may decimate the population or drive it to extinction.

Mary Bagley, LiveScience Contributor

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Genetics: The Study of Heredity - Live Science