All posts by medical

Anatomy of the Trump presidency – The Hindu

In an earlier article in this newspaper (Understanding the Trump phenomenon, August 5, 2016), I suggested that it was necessary to take Donald Trumps candidacy and its implications more seriously than many were doing then. Six months into the Trump presidency, the American media remains fascinated with the new reality show that has entered the White House.

As every small skirmish, move and tweet is given inordinate scrutiny and attention, it is easy however to lose sight of the big picture. What have we, in fact, learnt about the United States in the months since November 2016? How is this new information going to be useful in understanding the future path of the U.S., as well as its ongoing relationship with the rest of the world? Here are some suggestions and speculations.

The first point to be taken note of is that, despite the widespread disapproval of Mr. Trump in the media and the political and intellectual classes, he still has an approval rating in excess of 35% with the American public. Given Mr. Trumps rather erratic conduct so far, there seems no reason to believe that this rating will fall much further, no matter what he does. A small part of this can be accounted for by legitimism, that is, the need to support an authority figure. But far more important is the suggestion that over a third of the American public is currently made up of inflexible, hardcore right-wing and populist elements. Racism surely plays a role here too. The presidency can be won for the Republicans by adding roughly 15% of votes to this core constituency. In contrast, the Democratic Party does not have a solid base that measures up to this demographically. For them, to drum up numbers in the high-40% or more is thus a more difficult task. As American demography evolves, this could change, but only by the 2030s.

Second, the American electoral system as such is irrevocably broken, and yet there is no collective desire to fix it. In 2000, George W. Bush lost the popular vote to Al Gore by about 5,40,000 and yet won the election (this was the first time that it had happened since 1888). In 2016, Donald Trump then lost the popular vote to Hillary Clinton by a far larger margin of over three million votes. Still, currently there is no broad move afoot to reform the system, on the part of either major party, or to ensure that this does not happen again. This is in part because of American cultural hubris, which does not allow them to admit that their electoral system is far inferior to, say, that in use in France.

A third point concerns Mr. Trumps domestic agenda. Too much attention has been focused so far on the trench warfare regarding health care. So far, it has proven impossible to replace Obamacare, an ironical fact given that many of those who would have been adversely affected probably voted for Mr. Trump. At the same time, Mr. Trump has already placed one conservative Supreme Court judge, Neil Gorsuch, and may have a chance to effect still more changes. He has significantly turned back the clock on environmental legislation. By 2020, he will have effected many other major domestic policy changes in one or the other fashion. Again, this is an indictment of the American political system, which gives far too much power to the executive, and even to a President who has lost the popular vote.

The fourth point is more crucial still, and concerns the projection of American power abroad. Since the end of the Cold War, and the emergence of the unipolar American-dominated system around 1990, speculation has gone on regarding the nature of potential challenges to it. These could come from other state-systems, such as China, or the European Union, or from unclassifiable systems and forms, such as al-Qaeda or the Islamic State. But few could have predicted that the real challenge would come from within the U.S. itself. Yet, this is what has happened. The Trump administration appears singularly unconcerned with, and inept in dealing with, foreign policy, and after all its core internal constituency is firmly isolationist in its inclinations. The State Department is today in utter disarray. The Secretary of State, Rex Tillerson, is from the petroleum industry and seems out of his depth; so that rumours even surface regularly of his imminent resignation.

Based on the past six months, it seems likely that by 2020, the systematic projection of American power on a global scale would have shrunk considerably.

Whatever the direct reality of Russian interference in the 2016 U.S. elections, there can be no doubt that this outcome suits the Putin regime well. The Russian view appears to be that any political system that is nave enough to be manipulated from the outside deserves what it gets anyway. It could even be argued perhaps that the fresh emergence of a multipolar world is no bad thing. A system largely managed by an inept U.S. diplomatic apparatus is hardly attractive, even to the U.S.s erstwhile allies across the Atlantic.

To sum up, the Trump presidency is the product of a flawed political system that will obstinately not admit its flaws. In spite of this, it will surely have a significant impact over the medium term, both domestically and internationally. On the domestic front, it may be possible to turn some things back, depending of course on the outcome of the 2020 U.S. election. Where the impact is likely to be lasting, and not really reversible, is on the international front.

Sanjay Subrahmanyam is Professor of History at UCLA

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Anatomy of the Trump presidency - The Hindu

Rosewood’s Jaina Lee Ortiz cast as female lead in Grey’s Anatomy spinoff – Flickering Myth (blog)

Back in May it was announced that ABC had placed a straight-to-series order for a new Greys Anatomy spinoff based around a group of heroic firefighters, and now comes word from Deadline that Jaina Lee Ortiz (Rosewood) has been cast as the female lead.

The 10-episode drama is being penned by Greys Anatomy executive producer and co-showrunner Stacy McKee and takes place in a Seattle firehouse, detailing the brave men and women from the captain to the newest recruit who risk their lives and their hearts both in the line of duty and off the clock.

The main characters of the new spinoff are set to be introduced in an episode of the upcoming fourteenth season of Greys Anatomy before the show premiers in midseason. It is the second spinoff from the long-running medical drama series after Private Practice, which ran between 2007 and 2013.

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Rosewood's Jaina Lee Ortiz cast as female lead in Grey's Anatomy spinoff - Flickering Myth (blog)

Anatomy of a Grave-Hunt – Big Think

Where exactly is the grave of Andreas Vesalius? This historical mystery, at the unlikely intersection of anatomy, archeology and cartography, could soon be solved. But not without a final crowdfunding effort.

It's a mystery tinged with irony. Vesalius (1514-1564) popularised autopsies and (unwittingly) kicked off the centuries-long trend of 'resurrectionism': snatching bodies for dissection by medical students. Now it's his own grave that scientists are after, and their search involves a studious postmortem of the landscape where he was buried, with ancient maps as material evidence.

The search started some time before 2014, the 500th anniversary of Vesalius's birth. To celebrate that event, medical artist Pascale Pollier set out to reconstruct the face of Vesalius, from his actual skull a fitting tribute to the father of modern anatomy. But where was that skull? The historical record showed that Vesalius died on the Greek island of Zakynthos. And that's where the trail went cold.

16th-century map of Zakynthos, transposed on a topographically accurate modern map.

It's fair to say that few scientists have been as consequential for the development of modern science in particular medical science as Vesalius. So how could his last resting place have been neglected, forgotten and ultimately lost?

Born in Brussels to a family of apothecaries and physicians, Andries van Wesel later latinised his name to Andreas Vesalius, as was the fashion among Renaissance scholars. He studied anatomy in Paris and Louvain, where he famously robbed a corpse from a gibbet outside the city walls in order to procure a complete skeleton. He obtained his doctorate in Padua in 1537, then immediately received a professorate there, teaching surgery and anatomy.

His seminal work is the seven-volume De humani corporis fabrica ('On the Fabric of the Human Body'), published in Basel in 1543, when Vesalius was just 29 years old.The book is a milestone in the transition from the symbolic approach to medicine to an empirical one. With his insistence on learning via dissection of the human body, Vesalius not only improved upon, but even superseded Galen, whose teachings on medicine had been authoritative for over a millennium, despite the fact that Galen's autopsies on Barbary macaques were as close as he got to human anatomy.

The Fabrica has been called the most beautiful medical book ever published, combining the best science, art and typography that 16th-century Europe had to offer. In 2011, the only completely coloured first-edition copy of the Fabrica known to exist (probably the one presented by Vesalius to Charles V in the autumn of 1543) sold at Christie's for over $1.6 million, more than double the highest estimate of $600,000. Because the colouring was most likely carried out under the supervision of Vesalius himself, the author's portrait provides the only historical basis for our knowledge of Vesalius's complexion and hair colour.

For Vesalius, publication of the book also marked a turning point in his career. He left academia to become the personal physician to Emperor Holy Roman Emperor Charles V and from 1556 to his successor Philip II and their respective entourages, in Spain.

In 1564, Vesalius, a devout Catholic, left Spain for a pilgrimage to Jerusalem. He visited the Holy Places, but never made it back. It was long assumed that he had been shipwrecked on the island of Zakynthos, then a Venetian colony. Scientists now think Vesalius fell ill on the sea voyage home with scurvy, some argue; general fatigue, say others. Recently rediscovered eyewitness reports say he collapsed on the quay of Zakynthos, dying in October 1564.

Previously, Vesalius was thought to have been buried at the Franciscan abbey at Kalogerata, near the beach. However, reports from European pilgrims to Jerusalem place the tomb at the local Catholic church of Santa Maria delle Grazie (1).

Ground plan of the church of Santa Maria delle Grazie (1806)

That further complicates matters, as the church was destroyed in the big earthquake of 1953 which levelled most of the buildings on the island. The ruins of the church were bulldozed into the sea, and it was never rebuilt. The city itself rose from its ashes on a slightly different street grid.

So in 2014, with the help of Belgian embassy in Greece, Belgian archeologists conducted Phase One of the Quest for the Lost Grave of Vesalius.Painstakingly matching historical maps of the area to satellite imagery and modern cartographic data, Dr. Sylviane Dderix identified the exact location of the ruins of the Santa Maria delle Grazie church: on the north side of the city, partly under the intersection of Kolyva and Kolokotroni streets, and partly under some adjacent houses built after the quake.

Location of the vanished church on the current street grid.

So far, so good. But now, to enrich the data of the first phase, more applied cartography is necessary, specifically: tracking down cavities, foundations and other subterranean anomalies via ground-penetrating radar (GPR) and electrical-resistivity tomography (ERT). The archeologists have now received permission from the Greek ministry of Culture to perform this non-invasive research. Work could start as soon as September, if the crowdfunding campaign to raise the necessary funds, now tantalisingly close its goal, is successful.

Location of the church on Google Earth.

If Phase Two produces actionable results, Phase Three would consist of targeted, small-scale excavations in areas that could hold the grave. And there is indeed a good chance that Vesalius is still in the ground, says Theo Dirix, of the Vesalius Continuum project: Previous construction work on the spot has already turned up funerary slabs, proving there was a cemetery. Moreover, one of them dates from around the time Vesalius was buried here.

One report suggests Vesalius's tombstone may have been looted in 1571 by the Turks. If bones are found without identifying inscriptions, it is hoped they will yield enough DNA for forensic analysis; the project has already tracked down descendants of Vesalius's mother Elisabeth Crabb for mitochondrial DNA comparison.

Zakynthos street grid pre-earthquake (blue) and post-earthquake (red).

There is however a small chance that bones yielded by the underground on this specific plot of Zakynthos belong to another luminary from centuries past. The church was constructed over a much older cemetery; in the 1540s, about two decades before Vesalius was interred at the church, a grave believed to be that of the famous Roman orator Cicero was discovered in its grounds.

Many thanks to Theo Dirix for the images used here. For more on the search for Vesalius's grave, go to Vesalius Continuum.

Strange Maps #850

Got a strange map? Let me know at strangemaps@gmail.com.

(1) Christoph Furer von Haimendorff, who visited Zakynthos in the year following Vesalius's death, gives the epitaph: ANDREAE VESALII BRUXELLENSIS TUMULUS, QUI OBIIT ANNO DOMINI M. D. LXIV. ID. OCTOBRIS, CUMEX HIEROSOLYMA REDIISSET, Anno Aetatis suae LVIII. Mariae de Gratia (however, Vesalius was 50, not 58 years old when he died)

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Anatomy of a Grave-Hunt - Big Think

Bachelor of Science in Biology: Concentration in Physiology …

The rapid growth of knowledge about the nature and function of biological mechanisms has made physiology a corner-stone of the biological and medical sciences. The Physiology program at San Francisco State University is designed to provide students with a strong background in the basic sciences and an opportunity to obtain either a general overview of the field or to specialize. Emphases in Physiology include the neurosciences, reproductive and endocrine physiology, and comparative and ecological physiology, and aging. Studies at the master's level may include, in addition to the above, emphases in ethology, the neural mechanisms of behavior, and human psychophysiology.

Teaching and research facilities include a modern, fully-equipped eight-story building with a variety of laboratories for behavioral, biochemical, electrophysiological, and anatomical studies. Additional fieldwork may be done in association with the Moss Landing Marine Laboratories, Sierra Nevada Field Campus, the Romberg Tiburon Center for Environmental Studies, the San Francisco Zoo, and Marine World. Research internships are currently being conducted in cooperation with the University of California, San Francisco; Veterans Administration Hospital; and the Pacific Medical Center.

The highly competent faculty, all with Ph.D. degrees, have research interests in comparative biochemistry, endocrinology, reproductive physiology, human sexuality, ecological physiology, environmental enrichment and behavior of captive wild animals, population biology and physiology of marine mammals, neurophysiology, and sensory electrophysiology.

Lower-Division Requirements (38 - 39 units)

Units

BIOL 230

Introductory Biology I

5

BIOL 240

Introductory Biology II

5

CHEM 115

General Chemistry I

5

CHEM 130

General Organic Chemistry

3

CHEM 215/216

General Chemistry II and Laboratory (3/2)

5

MATH 226

Calculus I

4

One course selected from the following:

3 - 4

MATH 124

Elementary Statistics

3

MATH 227

Calculus II

4

BIOL 458*

Biometry

4

One set of the following:

8

PHYS 111/112

General Physics I Laboratory (3/1) and

PHYS 121/122

General Physics II and Laboratory (3/1) OR

PHYS 220/222

General Physics with Calculus I and Laboratory (3/1) and

PHYS 230/232

General Physics with Calculus II and Laboratory (3/1)

Total lower-division requirements

38 - 39

Upper-Division Requirements (29-33 units)

BIOL 350

Cell Biology

3

BIOL 355

Genetics

3

CHEM 340 OR CHEM 349

Biochemistry I OR General Biochemistry

3

Physiology core courses selected from the following (one lecture must be Biol 612 or Biol 630)

9

BIOL 525

Plant Physiology (3)

BIOL 612

Human Physiology (3)

BIOL 616

Cardiorespiratory Physiology (3)

BIOL 617

Environmental Physiology (3)

BIOL 620

Endocrinology (3)

BIOL 621

Reproductive Physiology (3)

BIOL 622

Hormones and Behavior (3)

BIOL 630

Animal Physiology (3)

BIOL 640

Cellular Neurosciences (3)

BIOL 642

Neural Systems Physiology (3)

One Physiology Lab selected from the following:

2-4

BIOL 526

Plant Physiology Lab (2)

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Bachelor of Science in Biology: Concentration in Physiology ...

Anatomy & Physiology – a learning initiative

Lever Systems: Bone-Muscle Relationships

How do our bones and muscles work? What makes movement possible? These are just a few questions you may find yourself thinking about now and again, and although these questions cant be answered in a single article, we can tackle the idea of leverage and bone-muscle relationships. In this article well discuss mechanical advantage, mechanical disadvantage, the idea of a lever, fulcrum, effort, and load, classes of levers, and lever systems within the human body.

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How do muscles work? Picture a hand-woven quilt full of strong fibers that have different shapes, sizes, and elasticities. The fibers may converge toward a single point, or run parallel with other muscles. Maybe theyre circular (like the muscle fibers around your mouth and eyes), and attach obliquely. In short, the arrangement of a muscles fiber bundles (fascicles) determines its range of motion and power. In this article well discuss fiber arrangements and muscle mechanics.

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The human skeleton contains 206 known bones and because of its sheer scope, a classification system had to be invented. Typically, bones are classified into four categories by shape: long, short, flat, and irregular. The skeleton is again classified into smaller and more specific groups which well discuss in future publications. The seven functions of bone: support, protection, movement, mineral storage, cell formation, fat storage, and hormone production are briefly discussed as well.

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Anatomy & Physiology - a learning initiative

Pascoe to explore male physiology in second Faber book | The … – The Bookseller

Published July 25, 2017 by Natasha Onwuemezi

Faber is to publish Sex Power Money, the follow up to comedian Sara Pascoe's feminist exploration of the female body Animal....

Faber is to publish Sex Power Money, the follow up to comedian Sara Pascoe's feminist exploration of the female body Animal.

Laura Hassan, editorial director at Faber & Faber, acquired world all language and audio rights to the title from Dawn Sedgwick at Dawn Sedgwick Management. Faber will publish Pascoes second book in August 2018.

In Sex Power Money, Pascoe once again looks to evolution to explain why modern humans are "struggling to be better". The book will be part comedy, part anthropological investigation of the human condition with a focus on male physiology, psychology and hormones. Pascoe will ask questions about masculinity, the contradictory messages bombarding men and how maleness is constructed by our culture. "Much like Pascoes Animal: The Autobiography of a Female Body, this book will be funny, enlightening and open-minded all at the same time", the publisher said.

Pascoe said that during research for Animal, she kept finding that many of the issues affecting human beings were split "not along gender lines but financial".

"There is a direct correlation between vulnerability and poverty and I wanted to explore issues such as sex work and domestic violence not only as purely feminist issues. I also wanted to balance my exploration of the female body with my new fascination for the male - which is equally mysterious, surprising, and occasionally shocking. Our prehistoric ape behaviours have to be at the front of our minds if we want to improve as a species: we have to understand where we came from."

Hassan praised Pascoe's "generous spirit of investigation" in both her book and comedy writing. "She takes on the big knotty stuff of life and makes sense of it all," Hassan said. "This will be an essential and enlightening read."

Pascoe is a comedian, actor and writer. She has appeared on "Live At The Apollo", "Have I Got News For You?" and "The Thick Of It". She is also a columnist for the Guardian and has adapted Pride and Prejudice by Jane Austen for the Nottingham Playhouse and York Theatre Royal.

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Pascoe to explore male physiology in second Faber book | The ... - The Bookseller

UCI researchers use stem cells as cancer-seeking missiles – 89.3 KPCC

A close-up of cell mutations that cause cancer. Steve Gschmeissner/Science Source

Chemotherapy is brutal a medicinal atomic bomb that destroys large swaths of cells, both cancerous and normal. And as a result, patients are often left physically devastated.

In a new study published in Science Translational Medicine, scientists at UC Irvine say they've come up with a way to use stem cells to help ameliorate those side effects. Think of it as a surgical strike with cancer-seeking missiles.

Professor Weian Zhao and his colleagues from UC Irvine modified stem cells so that they'd be attracted to enzymes released by breast cancer tumors. So, when injected into the body, the stem cells seek out the cells and bond with them.

The enzymes the scientists identified cause tissue to clump up into bundles of collagen and protein to create stiff tumors. The tumors become lumps that a patient can sometimes feel, and they act as a protective home for the cancerous cells.

The stem cells release an enzyme of their own, in turn, activating a type of chemotherapy that's been injected into the patient, which is inert until in comes in contact with the enzyme. The idea being that the chemotherapy only causes toxicity to a localized area, instead of destroying everything in its path.

"We can use a stem cells to specifically localize and produce the drugs only at the tumor site, so that we can spare the healthy tissue," said Zhao. "So, we can make the treatment more effective and less toxic to the patient."

"I think this is pretty unique in a way that it can target specific metastatic tissues with reduced toxicity overall," said Min Yu, assistant professor at the department of Stem Cell Biology and Regenerative Medicine at USC. "So, in that sense, I think it's very novel and very unique approach."

Yu, who was not involved in the research, complimented the UCI team's methods and results, especially how effective the treatment was on the particular cancer cell that they focused on. However, she said, from patient to patient and cancer to cancer, there are a myriad of different cells responsible, making treatment notoriously difficult to generalize. The therapy isn't a sure thing.

Zhao acknowledged that his team has a while to go before it can prove that the treatment is effective in people. So far, it's only been tested in mice. As a result, FDA approval and human trials could be years away.

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UCI researchers use stem cells as cancer-seeking missiles - 89.3 KPCC

What the WARC 100 can learn from neuroscience – Warc

LONDON: The worlds most effective campaigns highlighted in the WARC 100 are doing many things right, but there is plenty of room for improvement, according to an industry figure.

Writing in the current issue of Admap, Heather Andrew, CEO of Neuro-Insight, outlines the extent to which previously identified key creative factors associated with long-term memory encoding are evident among campaigns in the 2017 WARC 100 where television advertising played a key role.

We found that, while almost all the winning campaigns consistently exploit some of these [six] key creative drivers, there are others that represent potential missed opportunities; and one factor to which even the strongest campaigns can be vulnerable, she reports.

The three factors that brands in the WARC 100 consistently exploited revolved around aspects of storytelling, including showcasing rather than overtly selling, making the brand intrinsic to the storyline, and having strong levels of interaction between characters all of which help drive memory encoding.

But Andrew identifies two areas that brands could better exploit: music and rhythm.

The highest levels of brain response are elicited by music that is perceived to drive the action, she notes, but many WARC 100 campaigns used a recessive soundtrack one that is present but which doesnt produce a higher response or which may even be a distraction that can have a negative effect on overall brand impact.

Effective use of breaks and pauses to direct the brain to key parts of the narrative elicit 20% higher memory response at key branding moments, but Andrew finds that many WARC 100 ads had an even rhythm with little contrast not necessarily a problem but potentially a missed opportunity.

More seriously, she warns that many run the risk of being damaged by conceptual closure when the brain pauses for a moment to process an aha! moment and for a second or so is unreceptive to new information.

Examples included taglines that sum up a story just prior to end branding, or executional details that act as a cue that the story is over before it actually is over.

The road to the WARC 100 is almost certainly littered with ads where great creative has failed to make a real-world impact as a result of conceptual closure, resulting in an ad that people love without ever being able to remember what brand was being advertised, Andrew says.

Data sourced from Admap

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What the WARC 100 can learn from neuroscience - Warc

Conde Nast uses neuroscience to prove its sponsor posts work – Digiday

Cond Nast is on a mission to prove itssponsored postsare resonating, using the backingof neuroscience.

In an attempt to demonstratethe efficacy of its branded videos on YouTube and Facebook, the media conglomerate teamed with market research firm Neuro-Insight to measurethe impact of its posts on memory encoding and emotional intensity. Using a method called steady state topography that monitors brainwave activity, Cond Nast tracked how 200 consumers interacted with its sponsored fashion, finance, beauty and auto posts.

The findings showed high levels of resonance forCond Nast posts across both platforms specifically, its videos were 60 percent more effective at memory encoding than traditional YouTube pre-roll advertising and 17 percent more engaging than general Facebook content, including user-generated posts from friends.

Josh Stinchcomb, chief experiences officer at Cond Nast, said ultimatelythe study served to affirm and legitimize the companysexisting digital efforts, butwill also help inform ways for the company to evolve across its brands.

Increasingly our social feeds and our YouTube channels are becoming major distribution points for all content we create, editorial and otherwise, he said. So much of advertising impact is subconscious. We really wanted to delve into how people were responding to advertising within the brain and get a more nuanced and holistic read.

Part of Cond Nasts higher resonance rates can be attributed to targeted advertising techniques that have made it easier to tailor content to a particular type of consumer or reader. For example, its now easier than ever to tailor fashion-centric Cond Nast videos to consumers using YouTube to seek outstyle tutorials. According to a recent study by social advertising consultancyStrike Social, fashion has the second highest ad viewership rate on YouTube across industries after education content at 13.4 percent higher viewership than the industry average, at 31.9 percent versus 27.7 percent.

Fashion has done very well at producing video content, said Jason Nesbitt, vp of media and agency operations at Strike Social. They have engaging creative and often have content that includes a popular celebrity, model of a good looking person. That always does well as far as viewership.

Enter today to join past winners like Ogilvy, Under Armour and Casper

Stephanie Fried, evp of research, analytics and business development at Cond Nast, said the studyprovides an important look at thesubconscious proclivities of its readers that helpsemphasize the impact of the companysads.

Opinions are subjective and relative to peoples individual perceptions while neuroscience is more objective and consistent across subjects,Fried said. There are some things people dont want to say but neuroscience still picks those things up. Its like a lie detector on the brain.

Nesbitt added that the benefit ofsponsored content in the digital age isbrands and publishers like Cond Nast can receiveinstantaneous analysisthat allows themto test campaigns.

Its not like traditional media where you choose a TVor radio station that might index higher due to a particular demographic, where you might not get the results till later and its harder to measure, he said. The luxury is having this data in real time and having these insights from the sheer mass data that you get.

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Conde Nast uses neuroscience to prove its sponsor posts work - Digiday