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Former MD Anderson researcher objects to retraction of his paper – Retraction Watch (blog)

A cell biology journal has retracted a 2016 paper after an investigation revealed that the corresponding author failed to include two co-authors and acknowledge the funding source.

According to the retraction notice, the Journal of Cellular Physiology retracted the paper after the University of Texas, MD Anderson Cancer Center found that last author Jin Wang had omitted two researchers from the list of authors, and had also failed to acknowledge funding from the U.S. National Institutes of Health (NIH).

But Wang tells a different story.

Wang, who worked at the MD Anderson Cancer Center in Houston until 2015 but now runs his own lab at Fudan University in Shanghai, told us that he wrote the paper by himself and only asked his former mentor at MD Anderson, Subrata Sen, for English language edits. Wang also said that the research was not funded by the NIH and that one researcher mentioned in the notice, Ann Killary, played no role in the work and thus should not have been an author.

Heres the retraction notice for Identification of Novel Biomarkers for Pancreatic Cancer Using Integrated Transcriptomics With Functional Pathways Analysis:

The above article from the Journal of Cellular Physiology, published online on 10 March 2016 in Wiley Online Library as Early View (http://onlinelibrary.wiley.com/enhanced/doi/10.1002/jcp.25353/), has been retracted by agreement between Gary Stein, the journals Editor-in-Chief, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation at the University of Texas, MD Anderson Cancer Center, which confirmed that the article was submitted and approved for publication by Dr. Jin Wang without acknowledgement of NIH funding received or the consent and authorship of Dr. Ann Killary and Dr. Subrata Sen, with whom the manuscript was originally drafted.

The paper has not yet been indexed by Clarivate Analytics Web of Science.

Wang explained that he worked as a postdoc in Sens lab at MD Anderson for almost seven years, and left the lab around May 2015. Before leaving, Wang said he sent Sen a draft of the paper to edit for language, not content. Wang said he also sent the paper to others for English editing and does not think Sens corrections warranted authorship. The paper was received by the journal in February 2016 and published online the following month.

Wang added:

By the way, Dr. Killary had never read this manuscript. We do not understand why and who said she had drafted this manuscript.

The papers acknowledgement section does not acknowledge Sen or Killary. It only calls out grant support received from the Shanghai Science and Technology Commission.

We reached out to both Sen and Killary for a response to Wangs remarks. We also contacted the institutions provost and compliance officer to ask for a copy of the investigation report. A spokesperson from MD Anderson Cancer Center got back to us with a statement:

The University of Texas MD Anderson Cancer Center is committed to the highest standards of scientific integrity and supports the Journal of Cellular Physiology for retracting the article, Identification of Novel Biomarkers for Pancreatic Cancer Using Integrated Transcriptomics with Functional Pathways Analysis.

Between2010 and 2015, Killary and Sen received more than $3.2 million in NIH grants to support their research identifying early biomarkers in pancreatic cancer. Although we do not know for sure whether the funding also covered the research in the Journal of Cellular Physiology paper, the projects focus on similar topics.

Sen was also a middle author on a2004 Journal of Biological Chemistry paper co-authored byHarvards Sam Lee, which wasretracted in 2015 after an investigation at the Roswell Park Cancer Institute uncovered data manipulation.

Conflicts over authorship have led to many problems in the literature. For instance, we recently explored how the International Committee of Medical Journal Editors (ICMJE) authorship guidelines which recommend that any author included on a paper should have made substantial contributions to the conception or design of the work ended a 20-year collaboration.

Hat tip: Kerry Grens

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Former MD Anderson researcher objects to retraction of his paper - Retraction Watch (blog)

COLUMN: Anatomy of a smear – Waynesboro Record Herald

Lee Goodwin

From the time I saw the news, I thought it was a prank. The more I read, I knew it wasn't. The more I read, the more I thought: this is a sick and scripted serial. This is what they want.

The more I thought, the more I now believe that ESPN doesn't care what average Americans think of reassigning an Asian announcer named Robert Lee from a Virginia game in Charlottesville. ESPN is a part of the Fake Reality, a postmodern phenomenon that seeks to undermine not the United States as a country but the American people by any means necessary.

Lee, who is Asian, was assigned to announce the Cavaliers Sept. 2 opener against William & Mary. However, due to the recent controversial rally and ensuing counter protest that occurred in Charlottesville on Aug. 13 and 14, ESPN decided to reassign Lee to the Youngstown State/Pittsburgh game instead.

Lee, the voice of Siena College men's basketball team who lives in Albany, New York, works part time for ESPN, and announces about a "dozen football games a year for ESPN (according to heavy.com). He started as an ESPN announcer in 2016, working college football and college basketball games.

Here's ESPN's full statement:

"We collectively made the decision with Robert to switch the games as the tragic events in Charlottesville were unfolding, simply because of the coincidence of his name. In that moment it felt right to all parties. It's a shame that this is even a topic of conversation and we regret that who calls play-by-play for a football game has become an issue."

I bet. I guess it was just a freak coincidence that Lee was assigned to cover a game less than a month after the violence in Charlottesville, when they could have easily picked any other announcer who wouldn't have such a coincidental name.

FoxNews reported, "ESPN notes that assignments are switched all the time."

That might be so. But why the added coverage and raging responses? This is what they want.

Here's more:

New York magazine reporter Yasha Ali received an email Wednesday morning from an ESPN executive (no attribution) that stated, "This wasn't about offending anyone. It was about the reasonable possibility that because of his name he would be subjected to memes and jokes and who knows what else. Think about it. Robert Lee comes to town to do a game in Charlottesville. The reaction to our switching a young, anonymous play by play guy for a streamed ACC game is off the charts reasonable proof that the meme/joke possibility was real."

Sounds like predictive news to me. Not to mention, even if there was no rally in Charlottesville, given the history of the Confederacy and General Robert E. Lee a Virginian what in the name of Jefferson Davis is ESPN doing assigning Robert Lee to a UVA football game in Charlottesville?

I have a strong gut feeling the network knew exactly what it was doing, and it wasn't doing alone. It's possible they had help from other sources. These types of decisions are probably done in meetings. Lee could have done any number of lower-rated games. He could have worked the Central Connecticut at Syracuse game Friday, Sept. 1.

The really offensive part of the email refers to memes and jokes targeted at Lee. This smacks of someone projecting prejudice at a third party and assumes that spectators will undoubtedly slander Lee. If ESPN wanted to make a statement, it should have not broadcast the game. Period.

The unnamed executive goes on to state, "So, when the protests in Charlottesville were happening, we raised with him the notion of switching games. Somethine we do all the time. We didn't make him. We asked him. Eventually we mutually agreed to switch. . . No bigger until someone leaked it to embarrass us and him. They got their way. That's what happened. No politically correct efforts. No race issues. Just trying to be supportive of a young guy who felt it best to avoid the potential zoo."

Okay, Mr. Executive, but the fact remains: why did ESPN assign Lee the game to begin with? Not only was it presumptous at the least, it was even more pretentious and rudely patronizing to suggest that, for his own safety, he switch games.

As for Lee, he isn't talking about it, and I can't blame him. He deserves to be left alone, but ESPN, they've been in business for nearly 40 years and should no better.

And as for the "leak" the executive speaks of, isn't that poetic justice? The media love leaks; they make for great breaking news.

I don't know why this story became what it did. But it did, because it was supposed to. Nothing happens by chance, at least nothing of this caliber.

I'm sure the execs at ESPN are rubbing their hands together and planning the next "leak" as we speak.

Contact Lee Goodwin at 717-762-2151, lgoodwin@therecordherald.com or on Twitter: @LeeG_RH

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COLUMN: Anatomy of a smear - Waynesboro Record Herald

EXCLUSIVE: Owen Hilariously Asks Arizona for Babysitting Tips in ‘Grey’s Anatomy’ Deleted Scene – Entertainment Tonight

Things suddenly seem to click for Owen, who finds some renewed hope in solving the crying baby mystery, but the hilarity doesnt end there. Arizona suggests that he jump up and down -- not like youre a piston, youre like a wave -- at first, to calm the baby down, but then for her own amusement. Watch the deleted scene in the exclusive video above.

There will be several new faces joining Greys in the upcoming 14th season. In addition to welcoming Kim Raver back as Teddy, ABCs long-running medical drama will introduce DeLucas sister, Carina, who will be played byStefania Spampinato, and will bring on Timeless star Abigail Spencer in a recasting as Owens sister, Megan.

Greys Anatomy kicks off season 14 with a two-hour premiere on Thursday, Sept. 28 at 8 p.m. ET/PT on ABC.

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EXCLUSIVE: Owen Hilariously Asks Arizona for Babysitting Tips in 'Grey's Anatomy' Deleted Scene - Entertainment Tonight

Out of 89 majors, Economics and Biology are two of the most popular. – The Daily Pennsylvanian

Photo: Julio Sosa

While Penn offers nearly 90 majors at the undergraduate level, some are more attractive than others at least on paper.

According to education site College Factual, some of the most popular majors at Penn are finance, business administration and management, economics, nursing and biology.

Wharton sophomore Victoria Sacchetti, who intends to concentrate in finance, was attracted to the program due to her interest in quantitative data.

I love being able to analyze stocks and see how the market is impacted by different things such as politics, she said.

She added that she thought the applicability of her field and the skill of finance professors in the Wharton School served to draw other students to the major.

College sophomore Julia Hines first became interested in economics during high school. Since arriving at Penn she said that she has grown to appreciate the versatility of the major.

I think many people are attracted to econ because it is such a marketable and applicable major, and econ graduates have a wide range of career options, she said.

Anne Duchene, an economics lecturer, also emphasized the marketability of an economics degree.

[Economics] teaches how to analyze, understand and think critically. Employers know that, she said. And that's why they express so much interest in economics majors so students know that the job opportunities are everywhere, not only in bank and consulting, but also in non for profit, government, etc.

Nursing, which may seem more like a degree, is in fact a major in Penn's School of Nursing, and one of the most popular ones. Other majors offered by the School of Nursing include nutrition, which is hosted in partnership with the College of Arts and Sciences, and Nursing and Health Care Management, which is offered as part of a dual-degree program with Wharton.

For Nursing sophomore Jessica Korducki, one of the most appealing aspects of the Nursing School is the accelerated style of the program. While many nursing programs in other schools require students to take foundational classes before applying to major in nursing, Penn allows you to take nursing courses even during freshman year.

Welcome back to school! Read our other stories on NSO including a map on where to hit the books once NSO is over and an investigation into what actually happens when students skip mandatory NSO events.

Wharton sophomore Rachel Trenne's said she intends to pursue a management concentration in Wharton because she appreciates the big picture aspect of businesses.

Being able to learn about all the different elements of business and how they impact overall decisions and strategy is really interesting to me, she said, adding that she thinks the management concentration is particularly appealing to qualitative thinkers.

For students in the College, biology is the most popular choice.

College sophomore Olivia Crocker said the biology major is particularly important for those, like herself, who are interested in scientific research. She works part time at a laboratory during the academic year and worked there full-time over the summer.

Biology professor Linda Robinson identified several other factors that contribute to the popularity of the major. These include a widespread general interest and aptitude in science and math, fascination with the natural world [and] cool new discoveries," as well as "the perception that there may be a good job market for those trained in Biology, including the medical field," she said.

Crocker said the major is also particularly popular among pre-med students, though she's personally not interested in hat path.

Im interested in cell biology because it is more related to the small-scale molecular interactions that form the basis of life, rather than more large scale, anatomical basis of life that I feel is more emphasized in the medical field," she said.

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Out of 89 majors, Economics and Biology are two of the most popular. - The Daily Pennsylvanian

EvergreenHealth unveils Neuroscience, Spine & Orthopedic Institute: 5 things to know – Becker’s Orthopedic & Spine

Kirkland, Wash.-based EvergreenHealth opened its Neuroscience, Spine & Orthopedic Institute on the main campus, according to Kirkland Reporter.

Here are five things to know:

1. The new institute encompasses four levels of the health system's DeYoung Pavilion.

2. To construct the institute, the health system also built two new floors, which will hold the musculoskeletal and orthopedic practices. The construction was a part of EvergreenHealth's 10-year Master Facility Plan.

3. The new floors house 51 exam rooms, two imaging centers, three procedural rooms and six pre- and postoperation rooms.

4. The Neuroscience, Spine & Orthopedic Institute offers orthopedics, spine surgery, physiatry, podiatry, neurosurgery and pain management.

5. Patients will now have access to in-clinic evaluation and diagnostic care, imaging, minimally invasive procedures, surgical consultations and rehabilitation in one location.

More articles on practice management:Menorah Medical Center acquires 3 physicians to form orthopedic clinic: 5 things to know Washington University School of Medicine new spinal cord injury clinical trial site: 7 takeawaysStudy: Obesity alone shouldn't determine TJR candidates

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EvergreenHealth unveils Neuroscience, Spine & Orthopedic Institute: 5 things to know - Becker's Orthopedic & Spine

Mayweather will beat McGregor, neuroscience predicts – Phys.Org

In Las Vegas, on August 26, the unbeaten American boxer Floyd Mayweather Jr and the immensely popular Irishman Conor McGregor will face off in a boxing ring, where only striking with hands while standing is allowed. It would be just another boxing match, albeit a huge one, except that McGregor is not even a boxer. Instead, he holds the lightweight and welterweight titles in mixed martial arts (MMA), an emerging combat sport where striking and grappling with both hands and legs is allowed, both while standing and on the ground.

It is an unprecedented match-up and some people believe that McGregor, with his speed, athleticism and youth (he is 11 years younger than Mayweather) has a shot at doing something that 49 professional boxers before him have not been able to accomplish. But scientific evidence from the neuroscience of expertise, an emerging field investigating the brain functioning of experts, warns against betting on an MMA fighter even one as skilled as McGregor upsetting a boxer in a boxing match.

The neuroscience of expertise

The performances of experts often leave us speechless, wondering how it is humanly possible to pull off such feats. This is particularly the case in sports. Consider the serve in tennis. Once the ball is in the air, the brain needs time to process the ball's trajectory and prepare an appropriate course of action, but by the time the body actually executes the required movements in response to these mental processes, the racket will do no more than slice the air, as the ball will have already passed by.

This is the paradox of fast reaction sports such as tennis or boxing: it is only when the ball or the punch is in the air that we can tell with certainty what is going to happen, but by then it is far too late to react in time, even for the quickest humans. The expert brain adapts to this problem by "reading" the intention of the opponent. The positioning and movements of feet, knees, shoulders and the serving hand in tennis give away clues about the direction and power of a tennis serve.

Similarly, the positioning of feet, hips and shoulders provide enough information for the boxing brain to anticipate a punch well in advance. This anticipation power of experts is the reason why the very best practitioners can look like characters from The Matrix, giving the impression of having all the time in the world in an environment where split-second responses decide who wins and who loses.

Being fast and having good reflexes in general is certainly helpful in rapidly changing environments like sports. But no speed in this world will be enough if the brain hasn't experienced and stored tens of thousands of movement patterns, which can then be reactivated and used for reading the situation at hand.

Muhammad Ali vs Jim Brown

This is illustrated by another unofficial cross-discipline event that occurred 50 years ago between the legendary Muhammad Ali and Jim Brown, National Football League (NFL) legend. Jim Brown was a force of nature. He was incredibly quick, immensely powerful, and his extraordinary coordination and reflexes made him one of the greatest NFL players. In the mid 1960s, aged 30, Jim Brown was bored with the NFL and was pondering other ways of making a living. One of them was boxing, a sport where his immense quickness and sheer power would seem to be especially useful.

He persuaded his manager to organise a meeting with Muhammad Ali, at that time at the peak of his powers, who happened to be in London, where Jim Brown was shooting a film at that time. They met in Hyde Park, where Ali used to work out while preparing for the next bout. Ali tried to persuade Brown to give up on his dream of being a boxer. Brown maintained that he was as quick and as powerful as Ali, if not more so, and if boxing suited Ali, it should suit him too.

A "sparring session" ensued, where Ali asked Brown to hit him as hard as possible. The problem was that Ali was never to be found at the spot where he had been standing a moment earlier. According to the legendary promoter Bob Arum, after about 30 seconds of swinging and missing by Brown, Ali pulled off one of his lightning quick one-two combinations and stopped Brown momentarily in his tracks. At that moment, Brown, visibly winded, clocked the situation and simply said: "OK, I get the point."

Don't expect McGregor to be so totally embarrassed, as Brown was. After all, MMA includes aspects of boxing and McGregor has had experience with the sport, unlike Brown. Still, that experience is limited because boxing is just a part of the MMA skill set (not to mention embedded in a context where one needs to employ leg strikes and takedowns). One can be certain that McGregor's brain has stored vastly fewer kinematic boxing patterns than the brain of a person who has boxed all their life, such as Mayweather Jr.

Mayweather Jr may be 40, he may have ring rust after being absent from the ring for almost two years, and McGregor is not only 11 years his junior but also possibly faster and stronger; but everything we know about the way experts' brains work tells us that the smart money is on Mayweather Jr recording a convincing win.

Explore further: How to stop boxing deaths and brain injury with a simple rule

This article was originally published on The Conversation. Read the original article.

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Mayweather will beat McGregor, neuroscience predicts - Phys.Org

Review: The physiology of pleasure – Honi Soit

Its not every day you can stumble into a tent on Eastern Avenue and learn how to improve your sex life. Luckily for us, sex therapist and media personality, Tanya Koens, laid bare the juicy deets on what makes sex fun, freeing and fulfilling last week. Tanya kicked off the University of Sydney Unions Radical Sex and Consent Week with a bang (pun certainly intended).

Ive never seen a room of USyd students more attentive than during Tanyas overview of the different male and female erogenous zones. Let me tell you, the list aint short. In fact, there are 40 parts on a female body that can cause orgasm. 40! I thought mastering one was challenging enough

What I found most striking from Tanyas talk was that it takes men and women the same amount of time to orgasm when masturbating in fact, just like the title of Justin Timberlake and Madonnas delectable 2008 pop collaboration, it only takes four minutes. I dont think they were talking about masturbating, but its a coincidence I just cant ignore.

However, despite the mutual four minutes it takes to climax while doin it solo, in partnered sex its a very different story. To reach orgasm with someone else, it typically takes males five and a half minutes compared to the 17 minutes for females.

Im no Einstein, but thats a pretty notable gap. So if women are physiologically capable of reaching orgasm as quickly as men, why is it that it takes us ladies so much longer to climax when were with a partner? According to Tanya, there a multitude of reasons.

For women, desire and arousal are wholly controlled by the brain, which controls the rest of our body. When women are with a partner, it can take more time to relax and trigger arousal in the brain, and thus blood flow in the vagina and other erogenous zones. Although this can be impacted by things like stress, nervousness, self-esteem issues, past experiences, and physical impairment (to name a few), it still takes women a little more time to become fully aroused in the absence of these factors.

As our personal sexpert suggested, whats important is that we take things nice and slow. Take time to touch each others entire bodies before going straight for the bullseye. After all, why rush to dessert when you can have a multi-course degustation?

Of equal importance, Tanya re-iterated what youve probably already heard several times before: communication is key. Making an effort to talk to your partner and find out what they like can go a long way. Before getting physical, connect with each other mentally first by using your words, she says. Who knew it was that simple?

On top of this gender imbalance in the time it takes to orgasm, when it comes to hook-up sex, the stats are even more divided. On average, a mere 4 per cent of women orgasm compared to a whopping 85 per cent of men. The rate of orgasm increases with the number of hook-ups between the pair, presumably because both parties get to know each other better. Clearly, communication and comfort have a lot to do with reaching the big O.

As alarming as this orgasm gap is, fear not! Tanya reminded us that reaching orgasm isnt the be all and end all of good sex. Dont make sex outcome focussed, she advised. Sex is about the journey, not the destination. That goes for everyone: so long as youre having fun, thats all that really matters in the end!

Content note: Some Rad Sex coverage uses language that reinforces the gender binary to reflect the content of reviewed events.Honiunderstands that this does not represent the identities of all our readers.

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Review: The physiology of pleasure - Honi Soit

New light cast on sea level, climate threats – Brunswick News

If it seemed like coastal flooding associated with king tides has been getting particularly worse in recent years, that is because it has, according to a new study by University of Florida scientists.

Essentially, a combination of weather factors and shifting atmospheric pressure pushed water up along the Atlantic coast south of Cape Hatteras, N.C., in what the authors call a sea-level rise hot spot.

King tides already cause regular incursions of seawater into many coastal communities, where continued (sea-level rise) is increasing the frequency of this so-called nuisance flooding, which may be further amplified by short-lived (sea-level rise) hot spots, the authors conclude in journal Geophysical Research Letters. We have demonstrated that (sea-level rise) hot spot anomalies are a recurring feature along the U.S. eastern seaboard related to the combined cumulative effects of (El Nio-Southern Oscillation) and (North Atlantic Oscillation) forcing.

The authors revealed they believe the cause of this sort of sea-level rise was similarly responsible for accelerated sea-level rise detected along the coast running from Massachusetts to North Carolina, something previously attributed to a slowing of a major Atlantic Ocean current.

This distinction is critical to the projection of (sea-level rise) along this heavily populated coastline and defines a new benchmark for ocean dynamic models to capture such a pattern of regional (sea-level rise) variability, the authors noted.

Meanwhile, a major federal climate change report receiving greater attention in recent weeks illustrates more clearly what researchers believe to be the factors driving long-term sea-level rise, along with other results from the effects of human behavior on the planet.

The last few years have also seen record-breaking, climate-related weather extremes, the three warmest years on record for the globe and continued decline in arctic sea ice, according to the Climate Science Special Report, a collaboration of 53 people across 13 agencies. These trends are expected to continue in the future over climate (multidecadal) timescales. Significant advances have also been made in our understanding of extreme weather events and how they relate to increasing global temperatures and associated climate changes.

Since 1980, the cost of extreme events for the United States has exceeded $1.1 trillion, therefore better understanding of the frequency and severity of these events in the context of a changing climate is warranted.

The report is part of the National Climate Assessment, something meant to take place every four years, but the NCA has only published three times in the 27 years since Congress passed the law creating it. And instructions on how to interpret the data into policy implementation will be a little more difficult, as Sunday the Trump administration disbanded the advisory committee tasked with that job.

Further, last week President Donald Trump signed an executive order reversing an Obama administration requirement that construction projects in coastal floodplains that receive federal dollars have to take into account sea-level rise and resulting flooding projections.

As predictions both get clearer and more dire from climate scientists, work is beginning to go into what might happen by the centurys end. Using a sea-level rise estimate of nearly six feet, Mathew Hauer leader of the University of Georgia Institute of Governments Applied Demography Program published a piece in the journal Nature Climate Change in April in which he estimates 13.1 million people in the United States could have to permanently move further inland.

Relationships between environmental stressors and migration are highly complex as press and pulse events trigger migration responses that range from short-distance temporary migration to permanent long-distance migration; some will move and others will not, Hauer wrote. (Sea-level rise) is unique among environmental stressors as the conversion of habitable land to uninhabitable water is expected to lead to widespread human migration without the deployment of costly protective infrastructure.

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New light cast on sea level, climate threats - Brunswick News

Researchers propose p-value change from 0.05 to 0.005 – University of Virginia The Cavalier Daily

In a forthcoming research paper from Nature Human Behavior, a group of scientists including University Psychology Prof. Brian Nosek propose to change the p-value threshold for statistical significance from 0.05 to 0.005 in order to enhance the reproducibility of data.

According to an article written by UCLA Biostatistics Prof. Frederick Dorey and published in the journal Clinical Orthopaedics and Related Research, a p-value is a calculated probability that tests a null hypothesis, a statement that expresses the opposite of the hypothesis being investigated in a scientific experiment.

This value is often required to be calculated in publishable research papers that compare quantitative data between two or more experimental groups, Chemistry Asst. Prof. Rebecca Pompano said.

A p-value allows scientists to determine statistical significance the notion that an experimental result is likely attributable to a specific cause rather than mere chance of their results. Smaller p-values suggesting strong evidence against the null hypothesis likely correlate with more precise data, indicating potential reproducibility and thereby credibility of a scientific experiment.

Presently, the accepted p-value for statistical significance rests at 0.05. As such, a p-values less than 0.05 represents statistical significance. This cutoff was arbitrarily determined by British statistician and geneticist Sir Ronald Fisher in the early 1900s.

Sir Ronald Fisher proposed it in one of his articles or books, Statistics Prof. and Chair of Statistics Karen Kafadar said in an email to The Cavalier Daily. As I recall, he tossed it off as If the probability of observing our data under our hypothesis is less than 0.05, we might consider that to be statistically significant. And that 0.05 seems to have stayed with us ever since.

A recent paper by a group of researchers from numerous academic institutions including the University of Southern California, Duke University, University of Amsterdam, University of Pennsylvania, Harvard University, Stanford University and the University of Virginia however, challenges the longstanding p-value of 0.05.

The lack of reproducibility of scientific studies has caused growing concern over the credibility of claims of new discoveries based on statistically significant findings, the paper, released as a preprint article on PsyArXiv last month, said. For fields where the threshold for defining significance for new discoveries is P < 0.05, we propose a change to P < 0.005. This simple step would immediately improve the reproducibility of scientific research in many fields.

This proposal seeks to encourage strength of evidence by calling probability values less than 0.005 significant and those between 0.05 and 0.005 suggestive, Nosek said in an email to The Cavalier Daily.

Current scientific literature varies in reliability between fields and research journals the primary sources of study publications. Commonly, lower-quality journals publish untrustworthy papers, as do some high-end elite journals, in which data presented may be cherry-picked by the investigator to present a case as more scientifically elegant than reality. These circumstances may be caused by a scientists lack of knowledge and proficiency in their field, or driven by an individuals desire for vocational success and economic incentive often furthered by larger numbers of publications, Biology Prof. Paul Adler said.

According to Pompano, the benefits of a stricter significance cutoff could include less false data in scientific literature. A lowered threshold could also reduce p-hacking, Asst. Biology Prof. Alan Bergland said.

In p-hacking, people can use websites or programs to find correlations between variables in their experiments, and this allows them to contort their results to fit their desired narrative, Bergland said. You can plot different variables against each other and come across correlations that are completely nonsense, but related. P-hacking would still be possible even if the threshold was lowered to 0.005, but certainly harder.

While the change in p-value may, by some extent, increase the reproducibility of data, researchers worry it could also inhibit scientific progress. A p-value of 0.005 is difficult to obtain when working with smaller sample sizes, which is often the case in pilot studies, human clinical trials and for ethical reasons when experimenting with live mammalian specimen, Pompano said. Ultimately, according to Adler, lowering the p-value would increase expenses, time needed to conduct experiments and false negatives results that incorrectly demonstrate absence of a particular condition within data.

Additionally, although a p-value can determine statistical significance, it is unable to predict the applicability of experimental data to human life.

It cannot tell you if the model for your data is right, or if your sample is representative of the population, or the probability that your hypothesis is true, Kafadar said. It can only tell you how consistent are your data with your hypothesis, assuming both that the sample is representative of the population and the model you are using is correct. If neither of those assumptions is true, the p-value may be misleading.

Due to such limits of the p-value, Adler and Pompano believe errors in experimental design the setup of a procedure undertaken to test a hypothesis are a more immediate source of defects in scientific validity. Both professors said a p-value change is unnecessary.

Essentially, you cant just look at a p-value and decide if the results are reproducible. You have to look at the question being asked and if the experimental design that was being performed actually allows you to answer that question at all, Pompano said. And then, does the data support the answer that the author has concluded? I think the p-value alone is one small piece of assessing the conclusion of the experiment.

In other fields examining non-binary hypotheses, such as experimental physics, a p-value is rarely utilized and therefore unrelated to reproducibility errors. Rather, systematic uncertainties like varying machinery usage and ill-defined experimental design play larger roles in empirical blunders.

According to Physics Prof. Blaine Norum, reproducibility errors often encountered in physics are due to differing equipment types and apparatus setup from lab to lab.

The question is not a statistical question, but a question of systematic uncertainties that is, machinery or experimental design which are not addressed by a p-value, Norum said. How equipment is set up, how one configures it to get measurements varies between people, leading to reproducibility errors from lab to lab. A p-value is a statistically derived quantity, and it doesnt address those issues.

Researchers have expressed that inconsistencies within published scientific data stem from flaws within the career structures of science, more specifically defined as an unstable job market and the immensely difficult nature of discovery, rather than statistical analyses.

In the structure of science, at least American science, a lot of the research is done by graduate students and post-doctoral fellows, so the only way for a faculty member to be successful and keep getting papers and grants is to have lots of people working for them theres a selective advantage to that, Adler said. But that only fuels the oversupply of scientists, meaning you have too many people chasing too few grant awards and people publishing less reliable data just for the sake of publishing a paper. And these problems are much more serious than the p-value.

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Researchers propose p-value change from 0.05 to 0.005 - University of Virginia The Cavalier Daily

Clouds, rain can’t wash fascination with solar eclipse from eyes in Missouri – Topeka Capital Journal

AMAZONIA, Mo. Texans Lorin and Chris Matthews traveled from the Brazos River to a gravel road splitting corn and soybean fields adjacent to the Missouri River to lay eyes on the moon eclipsing the sun.

The roadside crew included their four children Allyriane and Sterling, 12; Zayn, 10; and Lachlan, 8 as well as Lorins sister, Liskin Kruse, and Kruses daughter, Meredith. The contingent tried out an array of flimsy disposable protective glasses Monday as the moon started nibbling away.

Its very bright, yellow and glowing, Zayn said in describing the cosmic spectacle.

What do you expect? said Sterling, with attitude blending solar analysis and sibling sarcasm. Its the sun.

Lorin Matthews, a physics professor at Baylor University in Waco, and Liskin Kruse, a biochemistry professor at the University of Kansas Medical Center, were drawn to Amazonia, purported population 318, for the sake of family and science. Kruse confessed to being a space wanna-be, while Matthews was bedazzled by the ability of researchers to predict the path of an eclipse with sufficient clarity to let everyone take part.

Its amazing we can predict with such accuracy the location of the sun, the earth and the moon, she said.

If only Mother Natures calibration of thick clouds and rainfall could be anticipated with surgical precision. About the same time the moon was to block out 99 percent of the sun, gray clouds descended on the hamlet of Amazonia and began spitting rain.

Among the dozen or so people parked in this speck of the eclipses hot zone, a few were lucky enough to catch a break in the clouds for split-second glimpses of the most poignant moments of totality, when only the corona of light around the sun can be visible. In this darkness, celebrants in the neighborhood shot off fireworks and firearms.

Allen and Valerie Cassavaugh, of Hopkins, Mo., were two of the visitors in Amazonia to witness the day dying and being reborn after a couple of minutes.

They plunked down lawn chairs next to their vehicle and worked on ham-and-cheese sandwiches and potato chips until the action started in a flat landscape with few trees on outskirts of St. Joseph, Mo.

The sky darkened as promised at totality, and the bizarre colors of sunset could be witnessed in several directions. Still, those clouds wouldnt cooperate.

It was worth the risk, Valerie said, since the next eclipse wont throw this much shade on the central United States until 2024.

Were 60 years old, Allen Cassavaugh said. Were not sure if well be around for the next one.

Originally posted here:
Clouds, rain can't wash fascination with solar eclipse from eyes in Missouri - Topeka Capital Journal