All posts by medical

Spoiler Room: Scoop on Grey’s Anatomy, Supernatural, The Flash and more – EW.com (blog)

Want scoop on your favorite shows? Then come hang out in the Spoiler Room, where I attempt to satiate your need to find out whats coming up on TV. If you want spoilers on a specific show, send Qs to my Twitter: @NatalieAbrams.

What do you have on Greys Anatomy? BriannaYou may have heard that Greys Anatomy is heading into a lighter season, but trust me when I tell you that there will be some shocking news by the end of the two-hour premiere that will really make you question, well, everything.

Whats happening with Hell now that Crowleys dead on Supernatural? MaraIts pretty much what youd imagine. When one leader falls, another must step up. But the question is: Who will earn their spot in Hells throne? (Hint: It might be someone weve never met before.) There is a power vacuum, showrunner Andrew Dabb says of the situation in Hell. Into that power vacuum will step a new player for us. Once Crowley is gone, demon-kind and some of our players some weve met before and some that are new start asking themselves: What is the future of Hell? People come with various different agendas.

Do you have more scoop on The Flashs girls night out? PeachThat episode wont be the only girl power well be seeing this year. Were definitely going to see Iris relationship with Caitlin especially developed this season, which we havent seen before, which will be really nice for fans, Candice Patton tells me. Fans have been wanting to see more female dynamic on the show, and there will definitely be that. Theyre working closely together. Caitlin has been through so much herself in relationships, and I think if anyone can offer advice, it would be her, so shes there quite often to give Iris advice on her relationship with Barry and how to move forward.

What do you know about the Game of Thrones finale? HillaryFor starters, theres the biggest assembly of major GoT characters since the pilot (or Joffreys wedding, depending on how you count major). But the finale is less about big action and more about dramatic moments. Plus: The Arya and Sansa conflict will also come to a head.

Anything on Butchs turn as Solomon Grundy when Gotham returns? KyleWell, he wont appear in the premiere, but when he does resurface, things will be very different for the character formerly known as Butch. Hes been in a vegetative state at Gotham General and so in order to clear up space for more beds, the administrators at the hospital have him dumped in Slaughter Swamp, as one does in Gotham, executive producer John Stephens says. So he emerges reborn out of Slaughter Swamp as the character we know as Solomon Grundy. Bonus scoop? Stephens reveals that the first person Solomon will run into is none other than Ed Nygma, and seeing as how Solomon has no memory of Ed, we begin the story of a very unlikely friendship between these two who are sworn enemies but now, all of a sudden in season 4, are best friends as they move through Gotham.

Would love some SuperCorp scoop for Supergirl. JayHeres some good news and some bad news: Lena and Karas friendship will continue to grow, EP Andrew Kreisberg says. Theres a lot of Lena-Kara adventures early on in this season. The most interesting thing about Lena is that she is so good, and so moral, and believes in second chances, but she comes from this family of truly evil people. As people are going to realize over the course of this season, it doesnt take much to make you bad. People dont just turn evil. They do one small bad thing and then that leads to another, and then to another, and so any time youre watching Lena, youre always wondering, Is this the moment when she does the one small thing?'

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Do you have any scoop on Regina and Henrys relationship on Once Upon a Time? TinaOnce the duo is reunited, it will be heartbreaking for Regina to have missed so many years of Henrys life. You get to see a little bit of that, Lana Parrilla tells me. She basically sees him for the first time, and she is just like, Oh my god. Its jarring for her when she sees him for the first time, but shes also really happy for him because hes turned into this beautiful young man, and shes really quite impressed with him, but shes still getting to know him at this level.

Should we be expecting another MacGyver-Hawaii Five-0 crossover this year? TreyIf its up to Peter Lenkov showrunner on both shows the answer is yes. The best thing about that experience was learning how to do it, Lenkov says. Because a big part of it is the time difference between Hawaii and Atlanta and getting the actors there and getting them to do their scenes and not affect production on both shows. I think well be able to do it in a much bigger way the next time we do it.

Anything on The Blacklist please! AlyThe news that Red is Lizs father is going to quickly put the Task Force in jeopardy. Cooper, first and foremost, is going to be saddled with what to do with that, EP Jon Bokenkamp says. He is now faced with, What do I tell the higher ups and what happens to the Task Force? Cooper is a pretty above-the-board guy, so it is going to be something that all of them are going to have to deal with.

What can we expect from the rest of Halt and Catch Fires final season? CarlyYou know that cataloging project Gordon had Haley working on? Well, that little endeavor helps Gordon realize his introverted daughter shares his and Donnas technological brilliance, and Haley ends up joining her father and Joe as their business tackles the world of search. Over the course of that interaction, Haley has a lot of time with Joe, who, I think, recognizes similarities between the two of them that go beyond what Gordon is maybe immediately able to spot, teases co-creator Christopher C. Rogers.

This week in TV: Im still not over it.

Thats a wrap on this weeks Spoiler Room. Dont forget to tweet your Qs to @NatalieAbrams.

Additional reporting by Chancellor Agard and Samantha Highfill.

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Spoiler Room: Scoop on Grey's Anatomy, Supernatural, The Flash and more - EW.com (blog)

Fast-tracking international surrogacy: reforming the law for parental orders – Lexology (registration)

The legal procedure for obtaining a parental order in England and Wales is complicated. It can be both confusing and expensive for applicants.

In Re Z (Foreign Surrogacy: Allocation of Work: Guidance on Parental Order Reports) [2015] EWFC 90 Russell J said that international surrogacy cases invariably involve some legal complexity. As a result, all proceedings under section 54 of the Human Fertilisation and Embryology Act 2008 (s54 HFEA 2008) where the child was born outside of England and Wales are allocated to a High Court judge.

At the moment, applications for parental orders in international cases involve two hearings. The first is a directions hearing at which the judge timetables the filing of evidence, directs a parental order report and lists a final hearing. The second is the final hearing at which the order is made, usually without complication.

However, as surrogacy has increased in popularity, so has the number of relatively straightforward cases and the need for reform is clear. Not all international cases involve legal complexity, yet the stringent rules and processes continue to apply.

In these cases, it would seem eminently sensible if the two hearings could be condensed to one. This happened in a recent case, run by Penningtons Manches partner Simon Blain, instructing Andrew Powell of 4 Paper Buildings, where only one hearing was required.

There is great potential for these fast track or composite hearings to become the norm. A case may potentially be suitable for the fast track if:

Simon Blain comments: When the court procedure for dealing with international surrogacy cases was first drawn up, these cases were regarded as rare and exotic and stringent procedures were put in place. As increasing numbers of prospective parents choose surrogacy, the process has become normalised. By using a reputable agency in the foreign country, and by consulting expert lawyers in the UK, it is possible to significantly reduce the length, and therefore the cost, of the proceedings. Of course, there will always be less straightforward cases where the full procedure will need to be followed.

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Fast-tracking international surrogacy: reforming the law for parental orders - Lexology (registration)

EvergreenHealth opens neuroscience, spine and orthopedic … – Kirkland Reporter

EvergreenHealth announced the grand opening of its Neuroscience, Spine & Orthopedic Institute on the health systems Kirkland campus.

The Institute spans four levels of EvergreenHealths DeYoung Pavilion and includes two newly constructed floors to house the systems musculoskeletal and orthopedics practices, providing patients with the convenience of complementary services in one location.

The two new floors on levels four and five of the DeYoung Pavilion combine innovative design and technology to enhance patient care, while also accommodating the integration of EvergreenHealths musculoskeletal and orthopedics services.

Now, from a single location, patients receive in-clinic evaluation and diagnostic care, imaging, minimally invasive procedures, surgical consultation and rehabilitation within orthopedics, spine surgery, physiatry, podiatry, neurosurgery and pain management.

The new floors join EvergreenHealths neurological care practices located on the third floor, along with a comprehensive outpatient rehabilitation services center on the second floor.

Offering comprehensive neuroscience, spine and orthopedic services under one roof further helps us to meet the growing needs of our community, said Bob Malte, CEO of EvergreenHealth in a press release. As we continue celebrating 45 years of serving Eastside residents, the opening of these two new floors reinforces our ongoing commitment to advancing the health of all patients through high quality, multidisciplinary care.

The newly built-out floors are part of EvergreenHealths 10-year Master Facility Plan approved by the organizations Board of Commissioners in July 2015 to promote growth that enables EvergreenHealth to meet the communitys evolving health care needs. When the DeYoung Pavilion opened on the Kirkland campus in 2009, it reserved its top two levels as shelled space, allowing the health system to later develop the floors in response to increased demand and community growth.

The two new floors in the Neuroscience, Spine & Orthopedic Institute feature 51 exam rooms, two imaging centers, three procedural rooms and six pre- and post- procedure rooms. The spaces were thoughtfully designed to promote healing while providing ease of access for patients of all abilities, and offers continuity between services. For example, for patients receiving procedures, the overall flow from admission to discharge moves in a forward direction, with no need for backtracking. Tablets allowing for electronic patient self-check-in make the entire process more user-friendly for patients and efficient for staff members.

This new development is the result of many years of thoughtful and innovative planning, as part of our mission to expand EvergreenHealths musculoskeletal service offerings, said Yung Lee, DO, medical director of EvergreenHealths Sport & Spine Care practice in a press release. Our team is proud to continue the journey towards a more integrated model of care that best meets the needs of our patients.

Construction and development of the new unit was made possible by generous donations from Mike and Mary Kay Hallman, The Schultz Family Foundation, and Tom and Connie Walsh.

EvergreenHealth recently celebrated other expansion efforts across the health system, including the opening of a new urgent care center in Mill Creek, and two new inpatient floors in the Silver tower on the Kirkland campus.

For more information on the Neuroscience, Spine & Orthopedic Institute and to watch a virtual tour of the space, visit https://youtu.be/7-xC_sNOy7U and http://www.northwestsportbackjoint.com.

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EvergreenHealth opens neuroscience, spine and orthopedic ... - Kirkland Reporter

Page Rejoins UK Gluck Center’s Immunology Group – TheHorse.com

Photo: University of Kentucky's College of Agriculture, Food, and Environment

The University of Kentucky (UK) Gluck Equine Research Center recently welcomed back Allen Page, DVM, PhD, as a scientist and veterinarian. Page completed his doctoral degree in the UK Department of Veterinary Science in 2013.

Page said he decided to come back in April after working for the USDA for more than two years because he enjoyed the collaboration with colleagues he previously worked with during his previous five years at the Gluck Center. He particularly enjoyed the challenge of research that the Gluck Center has to offer.

I think that as somebody who has been working with horses my whole life, it is something that interests me as of means of helping the horses and owners from a welfare aspect and performance aspect, he said.

In his multifaceted role at the Gluck Center, Page works as a scientist and veterinarian working with David Horohov, PhD, chair of the Department of Veterinary Science and director of the Gluck Equine Research Center. Page manages the laboratory and is also the departments clinical veterinarian, a role that has him oversee the veterinary care of the departments 300 horses. He also has a small appointment working for the universitys attending veterinarian and serves as an alternate member on the Institutional Animal Care and Use Committee, where he will help review protocols and conduct site inspections for research projects.

Before he left UK, Page was involved in a study examining inflammation in racehorses and picked up the research when he returned. He and others in the laboratory are trying to develop an easy-to-run test that will give veterinarians and researchers an idea whether horses could be at risk for injury. The laboratory has also used the test to look at young horses, primarily 2-year-olds in training, to determine how fit they are and if they are responding appropriately to increased training. This is important to the industry because it could potentially help prevent horses from suffering career- and life-ending injuries.

Page recently completed a preliminary collaborative project with researchers from Lincoln Memorial University (LMU), in Harrogate, Tennessee, where they examined the effect of stabling versus pasture management on horses and the effect the management protocols had on lipids or surfactant (the material that lines the alveoli, or air sacs of the lungs) in their lungs. Future collaborative studies with LMU hope to look at the effects of long-term stabling with horses with asthma. This research is important to the industry because barns are typically dusty, dirty, and can exacerbate asthma in those horses.

He is also currently overseeing a pilot study looking at the longevity and the effect of different equine herpesvirus-1 (EHV-1) vaccines on the immune response in horses. Because it can cause abortions in pregnant mares and potentially deadly neurologic deficits all horses, EHV is a disease of interest to many in the equine industry. Page and colleagues are studying the duration of immunity and how long horses white cells (immune cells) will appropriately respond after being challenged with EHV-1.

Page has a bachelors degree in animal science and veterinary degree from University of California, Davis. He completed a yearlong internship with Hagyard Equine Medical Institute, in Lexington, Kentucky, after he graduated from veterinary school. He then came to UK and completed his doctoral degree and postdoctoral studies where his efforts primarily involved work with Lawsonia intracellularis, a bacterial disease of weanling and yearling horses.

Katie Lampert is a marketing and communications intern at the UK Gluck Equine Research Center.

Want more articles like this? Sign up for the Bluegrass Equine Digest e-Newsletter.

More information on Gluck Equine Research Center and UK Ag Equine Programs.

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Page Rejoins UK Gluck Center's Immunology Group - TheHorse.com

Drilling Down Into Myriad Genetics, Inc. (MYGN) – StockNewsJournal

Myriad Genetics, Inc. (MYGN) is an interesting player in the Services space, with a focus on Research Services. The stock has been active on the tape, currently trading at $29.52, up from yesterdays close by 0.92%. Given the stocks recent action, it seemed like a good time to take a closer look at the companys recent data.

Fundamental Analysis

This company has been competing with others in the Services space and offers its own combination of interesting factors Myriad Genetics, Inc. (MYGN) currently trades with a market capitalization of $2.03 Billion. That value represents a market adjusting for revenues that have been growing by 7.56 % on a quarterly year/year basis as of the companys last quarterly report.

The balance sheet health of any company plays a key role in its ability to meet its obligations and maintain the faith of its investment base. For MYGN, the company currently has $102.4 Million of cash on the books. You can get a sense of how sustainable that is by a levered free cash flow of $100.1 Million over the past twelve months. Generally speaking, earnings are expected to grow in coming quarters. Analysts are forecasting earnings of $0.21 on a per share basis this quarter. Perhaps, that suggests something about why 96.67% of the outstanding share supply is held by institutional investors.

Technical Analysis

Sometimes, we can understand most about a stock by simply looking at how it has been trading. Looking at the stocks movement on the chart, Myriad Genetics, Inc. recorded a 52-week high of $29.52. It is now trading 0% off that level. The stock is trading $25.76 its 50-day moving average by -3.76%. The stock carved out a 52-week low down at $15.15.

In recent action, Myriad Genetics, Inc. (MYGN) has made a move of +25.83% over the past month, which has come on weak relative transaction volume. Over the trailing year, the stock is outperforming the S&P 500 by 27.56, and its gotten there by action that has been less volatile on a day-to-day basis than most other stocks on the exchange. In terms of the mechanics underlying that movement, traders will want to note that the stock is trading on a float of 31.15% with $67.78 Million sitting short, betting on future declines. That suggests something of the likelihood of a short squeeze in shares of MYGN.

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Drilling Down Into Myriad Genetics, Inc. (MYGN) - StockNewsJournal

Magnetothermal Genetics: A Fourth Tool in the Brain-Hacking Toolbox – IEEE Spectrum

A scientist wanting to hack into an animals brain used to have three different tools to choose from: electriccurrent, drugs, and light. Now theres a fourth: magnetic fields. In a paper published last week in the open-access journal eLife, scientists at the University at Buffalo used magneto-thermal genetics to manipulate brain cells in mice, enabling the researchers to control the animals behavior.

Magneto-thermal genetics has been previously shownto activate neurons in anesthetized rodent brains, but this is the first time anyone hasreported using the tool to manipulate animal behavior, says Arnd Pralle, the University at Buffalo biophysicist who led the research.

Brain hacking tools help scientists better understand the wiring of the brainthe arrangement of neural circuits and which onescontrol different movements and behaviors. These tools could someday lead to the development of artificial human eyes and ears, or treatments for paralysis,traumatic brain injury, and diseases such as Parkinsons and depression.

Over the past few years, major funding agencieshave encouraged scientists and bioengineers to focus their work on the bodys internal wiring. The U.S. National Institutes of Health (NIH) and DARPA have been doling out grants for work on both the peripheral and central nervous systems.

Engineers play a key role in the research. The bodys nervous systems communicate, after all, in a language of electrical signals. Researchers must not only map those signals, but also figure out how to interface with them, and override them when they malfunction.

Magnetic fields can do the job (following some complicated, multi-step bioengineering). In Pralles experiments, he and his team injected a virus containing a gene and some helper genetic elementsinto the brains of mice. This genetic material gets incorporated into the DNA of the mouses brain cells, or neurons. The foreign gene makes the neurons heat sensitive. Next, they injected magnetic nanoparticlesinto a specific region of the mouse brain that latch onto the neurons in that region. They then applied alternating magnetic fields, which cause the nanoparticles to heat up a couple of degrees. The rise in temperature triggers the heat-sensitive neurons to open ion channels. Positively-charged ions flow into the neuron, causing it to fire.

Pralle demonstrated proof of the concept in 2010, and others, such as Polina Anikeeva, a professor of materials science and engineering at MIT, have since improved upon it. Those studies confirmed that the technique could indeed activate neurons in the rodent brain.

In the new study, Pralle and his team show how magneto-thermal genetics can manipulate behavior in mice that are awake and freely moving. In their experiments, they activated regions of the brain that made the mice run faster around the perimeter of their cages, spin in circles, and, eerily, freeze the motion of all four paws.

Those same behaviors have been induced in rodents by activating neurons using other brain hacking tools, including optogenetics (in which neurons are genetically sensitized to respond to light), and chemogenetics (in which neurons are genetically sensitized to respond to designer drugs).

Those three toolsmagneto-thermal genetics, optogenetics, and chemogeneticsare new and purely experimental. A fourth toolelectrical stimulationhas been around for decades, with some success in treating Parkinsons, depression, memory loss, paralysis, and epilepsy in humans.

None of the tools has made a dent, relatively speaking, in the range of functions that the brain, spinal cord and peripheral nerves control. Its like owning four different musical instruments and knowing how to play onlya few rudimentary toddler songs on each of them. That untapped potential has inspired scientists to continue to test and develop the tools.

That means overcomingthe shortcomings of each tool. Electrical stimulation of deep brain regions requires, at least for now, an invasive surgical procedure to implant electrodes. That limits the number of patients willing to undergo the surgery. The method is also limited in how specifically it can target small brain regions or cell types.

Optogenetic techniques can target specific neurons, but animals in these experiments usually have to be tethered to an optical fiber or other kind of implant that delivers the light, which can affect their behavior. Study animals undergoing chemogenetic modulation can run free, but their response to the drugs is much slower than to light or electrical stimulation.

Magneto-thermal genetic toolsare non-invasive, tetherless, and induce a response within seconds of turning on the magnetic fields. But theres controversy over how the tool works.

Pralles team has shown that the magnetic nanoparticles injected into the mouse brains latch onto the membranes of the neurons, thus restricting the heating to those membranes rather than diffusing out to the surrounding liquid. This makes little sense from a physics point of view, and contradicts basic principles of heat transfer, saysMarkus Meister, a bioengineer at the California Institute of Technology in Pasadena.

Meister has also argued that previous experiments in magnetogeneticsa sister tool to magneto-thermal geneticsthat involves a different mechanismcontradict the laws of physics.He laid out his back-of-the-envelope calculations last year ina paper ineLife, whichgarnered a lot of attentionin the field of neuromodulation.

However, Pralles main claim, that he successfully used magnetic heating to control animal behavior, looks well supported, Meister says. Bottom line, the reported effects on behavior look real, but just what the mechanism is behind them remains to be understood.

Pralle says his work clearly demonstrates and measures local heating at the cell membrane, showing that it does indeed occur. Why thats happening, however, is unclear, he says.We cannot completely explain why the increase in heat stays within a few tenths or hundredths of nanometers of the neuronal membrane, Pralle says. The heat should diffuse more quickly into the [surrounding] water solution, so it shouldnt have much of a local heating effect.

Several theorists and experimentalists, including Anikeeva, have formulated and are testingmodels to explain the phenomenon. Similar effects have been seen, measured and correctly predicted for laser heating of gold nanoparticles in water, Pralle says.

Anikeeva says she sees nocontroversy in Pralles latest work. Meisters argument is based on a model that isnot applicable to nanoscale heat transport, she says.

Next, Pralle plans to develop, in collaboration with Anikeeva,a magneto-thermal genetics tool that can modulate multiple areas of the brain simultaneously, allowing the researchers to more fully control behavior, or multiple behaviors at one time. If we dream about it we can overcome the technical hurdles, Pralle says.

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Magnetothermal Genetics: A Fourth Tool in the Brain-Hacking Toolbox - IEEE Spectrum

Studying Human Behavior in Dog Agility – The Bark (blog)

Investigating sex differences in the role of stress and hormones on affiliative behavior by people was the goal of a recent study. For anyone interested in the influence of hormones on behavior, the results are exciting, but its the dog angle thats most noteworthy to me.

The study measured peoples affiliative behavior towards their dogs after victory or defeat in an agility competition. (A qualifying score of 85 or better was considered a victory. Scores below 85 were classified as defeats.) Its gratifying that the researchers recognized the truly competitive nature of canine agility and its usefulness for studying reactions to victory and defeat. The main finding was that men and women exhibit different patterns of affiliative behavior based on whether they experienced success or failure, but they did not show different amounts of affiliative behavior overall.

One specific finding was that after defeat, women were more affiliative towards their dogs, but that men showed the reverse patternmore affiliative behavior after victory. Additionally, the higher their cortisol levels (associated with defeat), the more affiliative behavior the women showed, but men responded to higher cortisol levels with lower levels of affiliative behavior. Their conclusion is that affiliative behavior is a sign of shared celebration for men, but of shared consolation for women. (Its not clear how this impacts peoples relationships with their dogs as that was beyond the scope of this study, but I would LOVE to see further research that explores that question.)

Since the paper is written mainly for scientists concerned with the role of social stressors and hormones on affiliative behavior rather than for people interested in dogs, they had to explain what agility is and make the case that it is truly competitive. They wrote, As a rule, contestants take these competitions very seriously,an obvious understatement.

With their choice to study human affiliative behavior in the context of agility, the authors demonstrated the ever- increasing recognition of the importance of dogs in peoples lives.

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Studying Human Behavior in Dog Agility - The Bark (blog)

New app studies tick disease risks – Block Island Times (press release) (subscription) (blog)

An innovative and new behavioral study is being conducted on Block Island using a free smartphone app to examine how daily activities expose people to the risks of acquiring diseases transmitted by ticks. The all-mobile research study app, called the Tick App,is available to IOS and Android smartphone users.

The app was created by Columbia Universitys tick and Lyme disease research team, led by Dr. Maria Diuk-Wasser, a professor in the Department of Ecology, Evolution and Environmental Biology (E3B). It offers the Block Island community a way to understand what activities and specific locations on the island lead to the highest risk of tick exposure. The pilot study is open, and is seeking residents and visitors on Block Island to participate by utilizing the app through September 2017. Dr. Diuk-Wasser intends to report her findings before next spring.

A summary from the research team noted that the goal of the study is to evaluate the use of ecological momentary assessments as a tool to assess risk factors for Lyme disease. This study will be conducted on Block Island, and data on human behavior will be obtained from a smartphone application using momentary assessments methodology to assess real time behavior and movement.

Were excited about the app, said Dr. Diuk-Wasser, who noted that the pilot study was hatched out of collaboration with a colleague. Dr. Diuk-Wassers team began using the app in June, and will share the results with Dr. Peter Krause, a Senior Research Scientist studying vector borne diseases at Yale University. Dr. Krause and his team will test participants at the conclusion of the study at the end of September.

Dr. Diuk-Wasser said subjects will participate using the app for about three weeks during the study. She said the app tracks the participants range of movement daily providing mapping information about dangerous areas on the island. She is hopeful that her research draws a large field of participants.

Dr. Diuk-Wasser has been working on Block Island since 2010, investigating links between the islands environment, animal populations, and human cases of Lyme disease. Other members of her research team are Pilar Fernandez, an Earth Institute post-doctorate fellow, and Pallavi Kache, who will be starting her PhD program at E3B in the fall.

Fernandez, who has been leading the teams communication efforts, said the app provides a way to use new tools and resources to conduct our research.She noted that users can participate using either a username, or their own name if they choose. Were the only ones who will be accessing the data from the study, she said.

According to a press release, The Tick App uses a combination of pop-up survey questions and geolocation technology to collect data. With these functions, Dr. Diuk-Wassers research team will be able to uncover how peoples day-to-day activities and movement around the island play a role in their risk for tick bites and tick-borne diseases. This information can help develop disease-control programs that take the lifestyle of the Block Island community into consideration and help develop educational programs to reduce disease risk.

The Tick App asks participants to:

Answer two multiple-choice questions sent at random times each day about their current activity

Answer two multiple-choice questions at the end of each day about all the activities they did that day

Answer one fill-in-the-blank questionnaire at the end of each day about how many ticks they found on themselves and their pet (if applicable)

Turn on location services so that the participants movement around the island can be detected

The summary states that the aim of the research is to recruit 100 Block Island residents and 100 visitors who have a personal smartphone. Vulnerable populations, such as pregnant women, the elderly, or children, will be excluded. The study will produce highly precise behavioral data about tick exposure which will lead to deepen our understanding on what intervention strategies might be most needed and most effective, pertaining to the fight against tick-borne disease.

The Block Island Times reported on Dr. Diuk-Wassers five-year research study that she presented at the Island Free Library on July 11, 2016. During her presentation she explained the pivotal role that deer and mice play in the spread of tick-borne diseases on Block Island.

To learn more about the app or to schedule an interview, contact: Maria Diuk-Wasser, PhD, Associate Professor, Department of Ecology, Evolution, and Environmental Biology at Columbia University. Phone: 212-854-3355 E-mail: bitickapp@gmail.com, Website: http://www.columbia.edu/~mad2256, Study Website: https://thetickapp.org/ and Twitter: @diukwasserlab. Dr. Diuk-Wasser said she is seeking additional funding to further the evolution of the app and her studies, which she hopes to continue into the near future.

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New app studies tick disease risks - Block Island Times (press release) (subscription) (blog)

A new clue to hair loss: A misbehaving enzyme in follicle stem cells – STAT

T

he roots of hair loss run deep: Its linked to hormonal balance, immune response, stem cell signaling, and now, according to new research from University of California, Los Angeles metabolism.

The study, published inNature Cell Biology, finds that the metabolism in the stem cells embedded in hair follicles is different from surrounding cells. When they tinkered with that metabolic pathway in mice, they could either halt hair growth or make it proliferate. The UCLA researchers are now testing out a duo of drugs to try and prompt that hair to grow.

This is a STAT Plus article and is only available to STAT Plus subscribers.To read the full story, subscribe to STAT Plus or log in to your account.Good news: your first 30 days are on us.

Biotech Correspondent

Meghana covers biotech and writes The Readout newsletter.

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A new clue to hair loss: A misbehaving enzyme in follicle stem cells - STAT

How white supremacists respond when their DNA says they’re not … – PBS NewsHour

A white supremacist wears a shirt with the slogan European Brotherhood at a rally in Charlottesville, Virginia, U.S., August 12, 2017. Photo by Joshua Roberts/Reuters

Whether youre a white supremacist, a white nationalist or a member of the alt-right, much of your ideology centers around a simple principle: being white. The creation of a white ethnostate, populated and controlled by pure descendants of white Europeans, ranks high on your priority list.

Yet, when confronted with genetic evidence suggesting someone isnt pure blood, as white supremacists put it, they do not cast the person out of online communities. They bargain.

A new study from UCLA found when genetic ancestry tests like 23andMe spot mixed ancestry among white supremacists, most respond in three ways to discount the results and keep members with impure genealogy in their clan. Their reactions range from challenging the basic math behind the tests to accusing Jewish conspirators of sabotage.

Some argued their family history was all the proof they needed. Or they looked in the mirror and clung to the notion that race and ethnicity are directly visible, which is false.

But the real takeaway centers on a new, nuanced pattern within white supremacist groups to redefine and solidify their ranks through genetic ancestry testing, said Aaron Panofsky, a UCLA sociologist who co-led the study presented Monday at the American Sociological Associations 112th annual meeting in Montreal.

Once they start to see that a lot of members of their community are not going to fit the all-white criteria, they start to say, Well, do we have to think about what percentage [of white European genealogy] could define membership? said Aaron Panofsky, a UCLA sociologist who co-led the study presented Monday at the American Sociological Associations 112th annual meeting in Montreal.

And this co-opting of science raises an important reminder: The best way to counter white supremacists may not be to fight their alternative facts with logical ones, according to people who rehabilitate far-right extremists.

To catalog white supremacists reactions to genetic ancestry results, this study logged onto the website Stormfront. Launched in 1995, Stormfront was an original forum of white supremacy views on the internet. The website resembles a Reddit-style social network, filled with chat forums and users posting under anonymous nicknames. By housing nearly one million archived threads and over twelve million posts by 325,000 or more members, Stormfront serves as a living history of the white nationalist movement.

Over the course of two years, Panofsky and fellow UCLA sociologist Joan Donovan combed through this online community and found 153 posts where users volunteered the results of genetic ancestry tests. They then read through the subsequent discussion threads 2,341 posts wherein the community faced their collective identities.

No surprise, but white supremacists celebrate the test results that suggest full European ancestry. One example:

67% British isles18% Balkan15% Scandinavian100% white! HURRAY!

On the flip side, Panofsky and Donovan found that bad news was rarely met with expulsion from the group.

So sometimes, someone says, Yeah, this makes you not white. Go kill yourself,' Panofsky said. Much more of the responses are what we call repair responses where theyre saying, OK, this is bad news. Lets think about how you should interpret this news to make it to make it right.'

These repair responses fell into two categories.

Reject! One coping mechanism involved the outright rejection of genetic tests validity. Some argued their family history was all the proof they needed. Or they looked in the mirror and clung to the notion that race and ethnicity are directly visible, which is false, University of Chicago population geneticist John Novembre told NewsHour.

Genetically, the idea of white European as a single homogenous group does not hold up.

Though the genetics of whiteness are not completely understood, the gene variants known to influence skin color are more diluted across the globe than any random spot in the human genome. That is to say, humans appear, based on our skin pigmentation, to be much more different from each other than we actually are on a genomic level, Novembre said.

Others accused the ancestry companies of being run and manipulated by Jews, in an attempt to thwart white nationalism, but even other Stormfront users pointed out the inaccuracy of this idea.

Reinterpret:The biggest proportion of responses 1,260 posts tried to rationalize the result by offering an educational or scientific explanation for the genetic ancestry results. Many in the online community played a numbers game. If a genetic ancestry test stated someone was 95 percent white European, they would merely count the remaining 5 percent as a statistical error.

Many adapted this line of thinking to make exceptions for those with mixed ancestry. Nearly 500 posts made appeals by misapplying theories of genetics or by saying whiteness is a culture, not just biology an apparent contradiction to the mission of forming a pure ethnostate. This trend led some white supremacists to debate the boundaries of their ethnostate, Panofsky said.

They start to think about the genetic signs and markers of white nationalism that might be useful for our community, Panofsky said. [They say] maybe there are going to be lots of different white nations, each with slightly different rules for nationalism? Or an overlapping set of nations, that are genetically defined in their own ways?

But these arguments are moot, because these genetic ancestry boundaries are inherently built on shaky ground.

If it seems white supremacists are making arbitrary decisions about their ancestry tests, its hard to blame them. Direct-to-consumer ancestry testing is a slippery, secretive industry, built largely upon arbitrary scientific definitions.

Its black box because its corporate, said Jonathan Marks, biological anthropologist at the University of North Carolina at Charlotte. The way these answers are generated depends strongly on the sampling, the laboratory work that you do and the algorithm that you use to analyze the information. All of this stuff is intellectual property. We cant really evaluate it.

White nationalists carry torches on the grounds of the University of Virginia, on the eve of a planned Unite The Right rally in Charlottesville, Virginia, U.S. August 11, 2017. Picture taken August 11, 2017. Photo by Alejandro Alvarez/News2Share via REUTERS

Genetic ancestry companies assess a persons geographic heritage by analyzing DNA markers in their autosomal DNA (for individual variation), mitochondrial DNA (for maternal history) or their Y chromosome (for paternal history). The latter two sources of DNA remain unchanged from parent to child to grandchild, aside from a relatively small number of mutations that occur naturally during life. These mutations can serve as branch points in the trees of human ancestry, Panofsky and Donovan wrote, and as DNA markers specific to different regions around the world.

When genetic anthropologists examine the full scope of humans, they find that historical patterns in DNA markers make the case that everyone in the world came from a common ancestor who was born in East Africa within the last 100,000 to 200,000 years. Plus, groups intermingled so much over the course of history that genetic diversity is a continuum both within American and Europe, through to Asia and Africa, Novembre of the University of Chicago said.

WATCH: Years after transatlantic slavery, DNA tests give clarity

Genetically, the idea of white European as a single homogenous group does not hold up. The classic geographic boundaries of the Mediterranean, Caucasus, and Urals that have shaped human movement and contact are all permeable barriers, said Novembre. Most of the genetic variants you or I carry, we share with other people all across the globeIf you are in some ethnic group, there are not single genetic variants that you definitely have and everyone outside the group does not.

Commercial ancestry companies know these truths, but bend them to draw arbitrary conclusions about peoples ancestry, researchers say. They compare DNA from a customer to the genomes of people or reference groups whose ancestries they claim to already know.

23andMe, for instance, uses reference dataset that include genomes from 10,418 people who were carefully chosen to reflect populations that existed before transcontinental travel and migration were common (at least 500 years ago). To build these geographic groups, they select individuals who say all four of their grandparents were born in the same country, and then remove outliers whose DNA markers do not match well within the group.

These choices willfully bias the genetic definitions for both geography and time. They claim that a relatively small group of modern people can reveal the past makeup of Europe, Africa and Asia and the ancestral histories for millions of customers. But their reference groups skew toward the present and overpromise on the details of where people came from.

While 23andMe denounces the use of their services to justify hateful ideologies, they do not actively ban known white supremacists from their DNA testing.

A study by 23andMe reported that with their definition of European ancestry, there is an average of 98.6 percent European ancestry among self-reported European-Americans. But given all Ive said, we should digest this with caution, Novembre said. An individual with 100 percent European ancestry tests is simply someone who looks very much like the European reference samples being used.

Though ancestry companies cite research that claims genetic tests can pinpoint someone within 100 miles of their European ancestral home, thats not always the case. Marks offered the recent example of three blond triplets who took an ancestry test for the TV show The Doctors. The test said the triplets were 99 percent European. But one sister had more English and Irish ancestry, while another had more French and German. Did we mention they are identical triplets?

That shows you just how much slop there is in these kinds of of ancestry estimates, Marks said.

Marks described commercial ancestry testing as recreational science because its proprietary nature lacks public, academic oversight, but uses scientific practices to validate stereotypical notions of race and ethnicity.

While 23andMe denounces the use of their services to justify hateful ideologies, they do not actively ban known white supremacists from their DNA testing, BuzzFeed reported.

But white supremacists arent the only ones to buy into these wayward notions when genetic ancestry tests support their self-prescribed identities or reject the science when things dont pan out as expected. African-Americans do it too, as Columbia University sociologist Alondra Nelson found in 2008.

Consumers have what I call genealogical aspiration, Nelson told NewsHour. They often make choices among dozens of companies based on the kind of information theyre seeking. If youre interested in finding whether or not youre a member of the small group that has, for example, some trace of Neanderthal DNA, then youre going to go to a company that focuses on that.

She said Panofsky and Donovans study shows that white nationalists will engage in a process of psychic and symbolic negotiation when genetic ancestry results fail to satisfy their impossible idea for racial purity.

But Panofsky, who doesnt support or sympathize with white nationalists, believes these negotiations are not a reason to dismiss white nationalists as ignorant and stupid.

I think that is actually a dangerous view, Panofsky said. Our study reveals that these white nationalists are often engaging with genetic information in extraordinarily sophisticated ways.

Many white supremacists are dealing with toxic shame, a perpetual subconscious belief system where their sense of identity is negative.

White supremacists are trying to deal with the issue of identity as an intellectual problem, said Tony McAleer, the co-founder and board chair of Life After Hate, a counseling organization that rehabs white supremacists. But he said the rehab of white nationalist views doesnt start with challenging their mental gymnastics with data.

We need to deal with the emotional drivers first, McAleer said. University of Maryland did a study of violent extremists and what they found was the number one correlated factor with someone joining a violent extremist group was childhood trauma.

But McAleer continued that the emotional trauma fueling white supremacy extends past physical and sexual abuse. Many white supremacists are dealing with toxic shame, a perpetual subconscious belief system where their sense of identity is negative.

The person feels at a subconscious level theyre not good enough, McAleer said. One way to react to that is to perpetually spend all of your efforts to prove to the world that you are a winner.

So, Life After Hates antidote to this shame is compassion and empathy, he said. Rather than toss statistics about how Muslims arent flooding the country and do not lead to spikes in crime, they will take a white supremacist to an Islamic center and have them sit down and spend time there.

A personal connection is a much more powerful way to change the dynamics within a person, than it is to re-educate the dataset thats in their head, McAleer said.

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