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Cell Biology :: Science Publishing Group

Endriyas Kelta Wabalo, Chala Kenenisa Edae

Pages: 33-46Published Online: Jan. 4, 2019

Divine Mensah Sedzro, Sm Faysal Bellah, Hameed Akbar, Sardar Mohammad Saker Billah

Pages: 20-32Published Online: Oct. 29, 2018

Toshikazu Nishimura

Pages: 9-12Published Online: May 5, 2018

Shuhei Soeda, Hideo Taniura

Pages: 13-19Published Online: Aug. 2, 2018

Sheila Maureen Benson, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Mayank Gangwar, Snehasis Jana

Pages: 1-8Published Online: Feb. 9, 2018

Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, William Dean Plikerd, Peter L. Surguy, Robert John Kock, Rolando Baptista Piedad, Russell Phillip Callas, Sakina A. Ansari, Sandra Lee Barrett, Sara Friedman, Steven Lee Christie, Su-Mei Chen Liu, Susan Elizabeth Starling, Susan Jones, Susan Mardis Allen, Susanne Kathrin Wasmus, Terry Ann Benczik, Thomas Charles Slade, Thomas Orban, Victoria L. Vannes, Victoria Margot Schlosser, Yusif Sarkis Yamin Albino, Mayank Gangwar, Snehasis Jana

Pages: 66-75Published Online: Dec. 11, 2017

Abida Sultana, Mohammad Nurul Amin, Muhammed Yusuf Miah, Ashish Kumar Sarker, Md. Mahabub Alam Rasel, Mohammad Tarek Aziz, Farzana Sharmin, Md. Abdul Hakim, Hosneara Shiddika, Shajal Hossain Emon, Tanjina Parvin Tuli, Mst Monira Khanom

Pages: 57-65Published Online: Oct. 10, 2017

Elijah Yanda Shaba, Tsado John Mathew, Amos Ndarubu Tsado, Abdulfatai Aiyede Otori, Emaka Ogbonna

Pages: 53-56Published Online: Mar. 30, 2017

Wedad M. Al-Adiwish, Maryam A. S. Abubakr, Naowara M. Alarafi

Pages: 45-52Published Online: Mar. 1, 2017

Dare Babatunde Joseph, Olayemi Olamide Samuel, Falana Benedict Abiola, Duru Francis I. Ogueri, Osinubi Abraham A. A.

Pages: 38-44Published Online: Jul. 18, 2017

Cell Biology (CB), a journal of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions focusing on cellular dynamics, motility and differentiation, particularly if related to cellular biochemistry, molecular biology, immunology, neurobiology, and developmental biology are encouraged. Manuscripts describing significant technical advances are also welcome. The topics related to this journal include but are not limited to:

Cell adhesion and motility

Cellular communication

Cell cycle and division

Cell growth, survival, and death

Cell structure and dynamics

Cellular disease mechanisms

Cytoskeleton and molecular motors

Gene expression and RNA metabolism

Methods and techniques

Organelle homeostasis

Protein and membrane trafficking

computational cell biology

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Cell Biology :: Science Publishing Group

Tooth | anatomy | Britannica.com

Tooth, plural teeth, any of the hard, resistant structures occurring on the jaws and in or around the mouth and pharynx areas of vertebrates. Teeth are used for catching and masticating food, for defense, and for other specialized purposes.

The teeth of vertebrates represent the modified descendants of bony dermal (skin) plates that armoured ancestral fishes. A tooth consists of a crown and one or more roots. The crown is the functional part that is visible above the gum. The root is the unseen portion that supports and fastens the tooth in the jawbone. The root is attached to the tooth-bearing bonethe alveolar processesof the jaws by a fibrous ligament called the periodontal ligament or membrane. The neck of the root is embraced by the fleshy gum tissue (a specialized area of connective tissue covered with mucous membrane that lines the mouth cavity). The shape of the crown and root vary among different teeth and among different species of animals.

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human digestive system: The teeth

The teeth are hard, white structures found in the mouth. Usually used for mastication, the teeth of different vertebrate species are sometimes specialized. The teeth of snakes, for example, are very thin and sharp and usually curve backward; they function in capturing prey but

All true teeth have the same general structure and consist of three layers. In mammals an outer layer of enamel, which is wholly inorganic and is the hardest tissue in the body, covers part or all of the crown of the tooth. The middle layer of the tooth is composed of dentine, which is less hard than enamel and similar in composition to bone. The dentine forms the main bulk, or core, of each tooth and extends almost the entire length of the tooth, being covered by enamel on the crown portion and by cementum on the roots. Dentine is nourished by the pulp, which is the innermost portion of the tooth. The pulp consists of cells, tiny blood vessels, and a nerve and occupies a cavity located in the centre of the tooth. The pulp canal is long and narrow with an enlargement, called the pulp chamber, in the coronal end. The pulp canal extends almost the whole length of the tooth and communicates with the bodys general nutritional and nervous systems through the apical foramina (holes) at the end of the roots. Below the gumline extends the root of the tooth, which is covered at least partially by cementum. The latter is similar in structure to bone but is less hard than dentine. Cementum affords a thin covering to the root and serves as a medium for attachment of the fibres that hold the tooth to the surrounding tissue (periodontal membrane). Gum is attached to the adjacent alveolar bone and to the cementum of each tooth by fibre bundles.

Like most other mammals, humans have two successive sets of teeth during life. The first set of teeth are called primary, or deciduous, ones, and the second set are called permanent ones. Humans have 20 primary and 32 permanent teeth.

Primary teeth differ from permanent teeth in being smaller, having more pointed cusps, being whiter and more prone to wear, and having relatively large pulp chambers and small, delicate roots. The primary teeth begin to appear about six months after birth, and the primary dentition is complete by age 2 1/2; shedding begins about age 5 or 6 and is finished by age 13. The primary teeth are shed when their roots are resorbed as the permanent teeth push toward the mouth cavity in the course of their growth.

In humans the primary dentition consists of 20 teeth four incisors, two canines, and four molars in each jaw. The primary molars are replaced in the adult dentition by the premolars, or bicuspid teeth. The 12 adult molars of the permanent dentition erupt (emerge from the gums) behind the primary teeth and do not replace any of these, giving a total of 32 teeth in the permanent dentition. The permanent dentition is thus made up of four incisors, two canines, four premolars, and six molars in each jaw.

Incisor teeth are the teeth at the front of the mouth, and they are adapted for plucking, cutting, tearing, and holding. The biting portion of an incisor is wide and thin, making a chisel-shaped cutting edge. The upper incisors have a delicate tactile sense that enables them to be used for identifying objects in the mouth by nibbling. Next to the incisors on each side is a canine, or cuspid tooth. It frequently is pointed and rather peglike in shape and, like the incisors, has the function of cutting and tearing food.

Premolars and molars have a series of elevations, or cusps, that are used for breaking up particles of food. Behind each canine are two premolars, which can both cut and grind food. Each premolar has two cusps (hence the name bicuspid). The molars, by contrast, are used exclusively for crushing and grinding. They are the teeth farthest back in the mouth. Each molar typically has four or five cusps. The third molar in humans tends to be variable in size, number of roots, cusp pattern, and eruption. The number of roots for each type of tooth varies from one for incisors, canines, and premolars to two or three for molars.

The teeth of many vertebrates have been adapted for special uses. Rodents have curved incisors that are set deep in the jaws and which grow continually throughout life; hares and rabbits have similar teeth. The tusks of elephants are enlarged upper incisors. The tusks of the walrus are enlarged canines, as are those of the wild boar. In the pig the lower incisors lie close together and project forward to form a digging instrument. Baboons have enlarged canines for defense and display. Certain snakes have hollow teeth that function as needles to insert venom. The sawfish, the only animal with true teeth outside its mouth, uses the teeth on both sides of its snout to slash its prey. The forms, patterns, and arrangements of teeth in different species of animals are of great importance in determining their phylogenetic (taxonomic) relationships.

Caries, or tooth decay, is the most common disease of the teeth among humans. Apart from the common cold, it is perhaps the most frequent disease in contemporary society. Tooth decay originates in the buildup of a yellowish film called plaque on teeth, which tends to harbour bacteria. The bacteria that live on plaque ferment the sugar and starchy-food debris found there into acids that destroy the tooths enamel and dentine by removing the calcium and other minerals from them. Caries usually commences on surface enamel, especially in pits and fissures and between adjacent teeth. From the enamel the process of decay spreads to the underlying dentine, and may finally involve the tooth pulp. Aside from keeping the teeth clean through regular brushing and flossing, tooth decay can be greatly reduced by the addition of fluorides to drinking water. Caries is treated by removing decayed dental tissue and replacing it with inert filling substances.

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primate: Teeth

A dentition with different kinds of teeth (heterodonty)incisors, canines, and cheek teethis characteristic of all primates and indeed of mammals generally. Heterodonty is a primitive characteristic, and primates have evolved less far from the original pattern than most mammals. The principal changes are a

The teeth may be subject to certain irregularities in their alignment, such as an abnormality in the relationship between the teeth in opposing jaws (malocclusion). In a less-severe irregularity, one or more teeth may be out of alignment. Both types of problems are best treated early in life through the use of special fixed or removable appliances (i.e., braces).

Another common dental disorder is inflammation of the gum, or gingivitis. It usually commences at or close to the gum margin, often between adjacent teeth. Pockets form between the gum and the adjacent teeth, sometimes penetrating deeply into the tissues. This leads to further infection, with inflammation and bleeding from the infected gums. A principal cause of gingivitis is the buildup of plaque on teeth, which causes irritation of the gums and thus leads to their inflammation and infection.

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Tooth | anatomy | Britannica.com

Cell – Definition, Functions, Types and Examples | Biology …

Cell Definition

Cells are the basic unit of life. In the modern world, they are the smallest known world that performs all of lifes functions. All living organisms are either single cells, or are multicellular organisms composed of many cells working together.

Cells are the smallest known unit that can accomplish all of these functions. Defining characteristics that allow a cell to perform these functions include:

Below we will discuss the functions that cells must fulfill in order to facilitate life, and how they fulfill these functions.

Scientists define seven functions that must be fulfilled by a living organism. These are:

It is the biology of cells which enables living things to perform all of these functions. Below, we discuss how they make the functions of life possible.

In order to accomplish them, they must have:

The different cell types we will discuss below have different ways of accomplishing these functions.

Because of the millions of diverse species of life on Earth, which grow and change gradually over time, there are countless differences between the countless extant types of cells.

However, here we will look at the two major types of cells, and two important sub-categories of each.

Prokaryotes are the simpler and older of the two major types of cells. Prokaryotes are single-celled organisms. Bacteria and archaebacteria are examples of prokaryotic cells.

Prokaryotic cells have a cell membrane, and one or more layers of additional protection from the outside environment. Many prokaryotes have a cell membrane made of phospholipids, enclosed by a cell wall made of a rigid sugar. The cell wall may be enclosed by another thick capsule made of sugars.

Many prokaryotic cells also have cilia, tails, or other ways in which the cell can control its movement.

Prokaryote cell

These characteristics, as well as the cell wall and capsule, reflect the fact that prokaryotic cells are going it alone in the environment. They are not part of a multicellular organism, which might have whole layers of cells devoted to protecting other cells from the environment, or to creating motion.

Prokaryotic cells have a single chromosome which contains all of the cells essential hereditary material and operating instructions. This single chromosome is usually round. There is no nucleus, or any other internal membranes or organelles. The chromosome just floats in the cells cytoplasm.

Additional genetic traits and information might be contained in other gene units within the cytoplasm, called plasmids, but these are usually genes that are passed back and forth by prokaryotes though the process of horizontal gene transfer, which is when one cell gives genetic material to another. Plasmids contain non-essential DNA that the cell can live without, and which is not necessarily passed on to offspring.

When a prokaryotic cell is ready to reproduce, it makes a copy of its single chromosome. Then the cell splits in half, apportioning one copy of its chromosome and a random assortment of plasmids to each daughter cell.

There are two major types of prokaryotes known to scientists to date: archaebacteria, which are a very old lineage of life with some biochemical differences from bacteria and eukaryotes, and bacteria, sometimes called eubacteria, or true bacteria to differentiate them from archaebacteria.

Bacteria are thought to be more modern descendants of archaebacteria.

Both families have bacteria in the name because the differences between them were not understood prior to the invention of modern biochemical and genetic analysis techniques.

When scientists began to examine the biochemistry and genetics of prokaryotes in detail, they discovered these two very different groups, who probably have different relationships to eukaryotes and different evolutionary histories!

Some scientists think that eukaryotes like humans are more closely related to bacteria, since eukaryotes have similar cell membrane chemistry to bacteria. Others think that archaebacteria are more closely related to us eukaryotes, since they use similar proteins to reproduce their chromosomes.

Still others think that we might be descended from both that eukaryotic cells might have come into existence when archaebacteria started living inside of a bacterial cell, or vice versa! This would explain how we have important genetic and chemical attributes of both, and why we have multiple internal compartments such as the nucleus, chloroplasts, and mitochondria!

Eukaryotic cells are thought to be the most modern major cell type. All multicellular organisms, including you, your cat, and your houseplants, are eukaryotes. Eukaryotic cells seem to have learned to work together to create multicellular organisms, while prokaryotes seem unable to do this.

Eukaryotic cells usually have more than one chromosome, which contains large amounts of genetic information. Within the body of a multicellular organism, different genes within these chromosomes may be switched on and off, allowing for cells that have different traits and perform different functions within the same organism.

Eukaryotic cells also have one or more internal membranes, which has led scientists to the conclusion that eukaryotic cells likely evolved when one or more types of prokaryote began living in symbiotic relationships inside of other cells.

Organelles with interior membranes found in eukaryotic cells typically include:

As mentioned above, archaebacteria are a very old form of prokaryotic cells. Biologists actually put them in their own domain of life, separate from other bacteria.

Key ways in which archaebacteria differ from other bacteria include:

Archaebacterias unique chemical attributes allow them to live in extreme environments, such as superheated water, extremely salty water, and some environments which are toxic to all other life forms.

Scientists became very excited in recent years at the discovery of Lokiarchaeota a type of archaebacteria which shares many genes with eukaryotes that had never before been found in prokaryotic cells!

It is now thought that Lokiarchaeota may be our closest living relative in the prokaryotic world.

You are most likely familiar with the type of bacteria that can make you sick. Indeed, common pathogens like Streptococcus and Staphylococcus are prokaryotic bacterial cells.

But there are also many types of helpful bacteria including those that break down dead waste to turn useless materials into fertile soil, and bacteria that live in our own digestive tract and help us digest food.

Bacterial cells can commonly be found living in symbiotic relationships with multicellular organisms like ourselves, in the soil, and anywhere else thats not too extreme for them to live!

Plant cells are eukaryotic cells that are part of multicellular, photosynthetic organisms.

Plants cells have chloroplast organelles, which contain pigments that absorb photons of light and harvest the energy of those photons.

Chloroplasts have the remarkable ability to turn light energy into cellular fuel, and use this energy to take carbon dioxide from the air and turn it into sugars that can be used by living things as fuel or building material.

In addition to having chloroplasts, plant cells also typically have a cell wall made of a rigid sugars, to enable plant tissues to maintain their upright structures such as leaves, stems, and tree trunks.

Plant cells also have the usual eukaryotic organelles including a nucleus, endoplasmic reticulum, and Golgi apparatus.

For this exercise, lets look at a type of animal cell that is of great importance to you: your own liver cell.

Like all animal cells, it has mitochondria which perform cellular respiration, turning oxygen and sugar into large amounts of ATP to power cellular functions.

It also has the same organelles as most animal cells: a nucleus, endoplasmic reticulum, Golgi apparatus, etc..

But as part of a multicellular organism, your liver cell also expresses unique genes, which give it unique traits and abilities.

Liver cells in particular contain enzymes that break down many toxins, which is what allows the liver to purify your blood and break down dangerous bodily waste.

The liver cell is an excellent example of how multicellular organisms can be more efficient by having different cell types work together.

Your body could not survive without liver cells to break down certain toxins and waste products, but the liver cell itself could not survive without nerve and muscle cells that help you find food, and a digestive tract to break down that food into easily digestible sugars.

And all of these cell types contain the information to make all the other cell types! Its simply a matter of which genes are switched on or off during development.

1. Which of the following is NOT an essential function that all living things must perform?A. A living thing must reproduce.B. A living thing must be able to maintain its internal environment, regardless of external changes.C. A living thing must respond to changes in its environment.D. None of the above.

Answer to Question #1

D is correct. All of the above are essential functions of life!

2. Which of the following is NOT a type of prokaryotic cell?A. ArchaebacteriaB. Staphylococcus bacteriaC. Streptococcus bacteriaD. Liver cell

Answer to Question #2

D is correct. Liver cells are eukaryotic cells, like all cells from multicellular organisms!

3. Which of the following is NOT a eukaryotic cell organelle?A. PlasmidB. NucleusC. MitochondriaD. Chloroplast

Answer to Question #3

B is correct. Plasmids are pieces of DNA that are passed between prokaryotic cells. They are not organelles.

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Cell - Definition, Functions, Types and Examples | Biology ...

Cell Biology & Physiology Home

Faculty RecruitmentTenure-Track Positions

Candidates interested in applying for a position with the Cell Biology and Physiology department at Washington University should view current openings and follow application instructions noted for each group of positions.Staff and Postdoctoral Positions

Congratulations to Laura Westergard and Heather True! Westergard, L. and True, H.L. (2014) Extracellular envionment modulatesLearn more

Congratulations to Laura and Heather on their newest publication in Molecular Microbiology! Westergard, L, and True, HL. (2014) Learn more

Alspach, E, Flanagan, KC, Luo, X, Ruhland, MK, Huang, H, Pazolli, E, Donlin, MJ, Marsh, T, Piwnica-Worms, D,Learn more

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Explore Cell Biology | Cellular Biology | Biology Explorer

Cells are often described as the basic unit of life. Cell biology is a sub-discipline of biological studies that deals with the study of cells in all aspects. From cell anatomy, cell death, cell respiration to the processes of cell divisions like mitosis and meiosis, cell biology covers all topics.

This subject is closely related to other important branches of science like genetics, biochemistry and molecular biology. Also known as cytology, cell biology is closely associated with immunology and developmental biology.

Originally derived from the Greek word kytos meaning contain, this area of biology strictly deals with the physiological properties of the cell, the organelles that present in these, cell structure, the pattern of interaction between cells and cell pathways.

The study of cells focuses on both single-celled organisms like bacteria and protozoa to complex, multi-cellular organisms like plants, animals and human bodies. Tracking down the nature of these cells, their functions and similarities and dissimilarities of cells in living organisms are all a part of the course.

Think about it what if you were never able to get an ailment traced? Today, you are aware of diseases and their symptoms. There are millions of health professionals at service trying you treat patients from the adversities and lethal impacts of malicious diseases like the Big C, Alzheimers disease, cystic fibrosis, meningitis or even malaria. These problems spring in at molecular levels. Therefore, by understanding how cells work and function, cell biologists are able to make new discoveries in the field of medicine.

After analyzing all forms of living organisms like plants, animals and human beings, cell scientists carefully discover a series of advanced drugs, vaccines and sedative to ensure proper cure to a serious ailment.

Why just diseases, cell biology has contributed towards the human fertility program. Even forensic teams put cell biology into practice to execute successful solutions like DNA fingerprinting to solve a murder or other complex criminal activities.

Cell biologists analyze plants and define their genetic behavior. These work wonders in encouraging the production of better and modified crops.

Various career paths open up once you have successfully accomplished a course on cell biology. Some of them are:

Here are the web resources on cell biology:

Cell and Molecular Biology OnlineAn Informational Resource for Cell and Molecular Biologists. Features resources for biology research and education, including protocols, lab home pages, journals, grants, professional societies, conferences, career information, online courses and biological images. Link

Cell Biology Division of the WWW VL BiosciencesA comprehensive listing of cell biology links divided into the major divisions. Link

Cell Biology InformationThis site contains addresses and hints for the active cell biologist and shall help you to get more information for your scientific work. Link

Cell IntelligenceTwo professors of cell biology argue that cells are intelligent. Read their hypothesis, methods, and bibliography. Link

FRIZ Biochem: new DNA chips using electrical read out technologiesFRIZ is dedicated to expanding the potential applications of microarrays for genomic screening using new DNA chip technologies. We develop new DNA arrays and produce reliable user-friendly biochips. Link

Jeremias AlleyCollection of free Cell Biology resources, organized by subject. Covers a new topic every week! Links to good sites, with descriptions and ranking. The page to visit if you are interested in Cell Biology but dont have a penny! The already published coverages include Mitochondria, ATP Synthase, Proteasomal and Ubiquitin-related Protein Degradation and Crytochromes. Link

Microarray StationLearn about microarrays, tissue microarrays, dna protein peptide and antibody microarrays. Protocols and vendors for gene chips. Also contains links to software and bioinformatics for microarray data analysis and statistics. Link

Molecular and Cellular Biology Resource SiteA graduate student resource site listing links for molecular, cellular, developmental and cytoskeletal biology. Link

The Cell web siteVery nice graphical tutorial for cell biology and microbiology. Link

The Kinesin HomepageA resouce site for information regarding the kinesin motor proteins. Link

Worthington Tissue Dissociation Guidecell isolation introduction, theory, techniques, and use-tested systems PLUS annotated references searchable by multiple criteria. Link

Cell Biology

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Explore Cell Biology | Cellular Biology | Biology Explorer

The Division of Biology & Biomedical Sciences

Immunology is the discipline of biology that examines the mechanisms of host defense against pathogenic agents. The study of the immune system offers a unique opportunity to analyze a complex multicomponent system consisting of molecules and cells that have documented physiologic relevance. Immunology has a strong foundation in biochemistry, molecular biology and cell biology.

Washington University School of Medicine has a large community of investigators who make immunology their primary focus. The research within our program spans a broad spectrum, ranging from studies at the basic structural and molecular levels of host defense all the way to clinical applications directed at significant health problems, such as cancer immunotherapy. The Program in Immunology has grown to include more than 50 research laboratories and the number continues to increase. This unusual concentration of immunologists was the stimulus that led to the formation of a separate Graduate Program in Immunology in 1986.

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The Division of Biology & Biomedical Sciences

Department of Molecular & Cell Biology

Congratulations to MCB Assistant Professor Stephan Lammel, recipient of the 2019 C.J. Herrick Award in Neuroanatomy! This award from theAmerican Association of Anatomists honors an early-career investigator who has made important contributions to biomedical science and the field of neuroanatomy.

Lammel will be honored at theAAA Closing Awards Ceremony Reception & Dinner in Orlando, Florida, in April 2019.

View all the 2019 AAA award recipients here.

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Department of Molecular & Cell Biology

Bleb (cell biology) – Wikipedia

In cell biology, a bleb is a bulge or protrusion of the plasma membrane of a cell, human bioparticulate or abscess with an internal environment similar to that of a simple cell, characterized by a spherical, bulky morphology.[2] It is characterized by the decoupling of the cytoskeleton from the plasma membrane, degrading the internal structure of the cell, allowing the flexibility required to allow the cell to separate into individual bulges or pockets of the intercellular matrix.[2] Most commonly, blebs are seen in apoptosis (programmed cell death) but are also seen in other non-apoptotic functions. Blebbing, or zeiosis, is the formation of blebs.

Bleb growth is driven by intracellular pressure generated in the cytoplasm when the actin cortex undergoes actomyosin contractions.[3] The disruption of the membrane-actin cortex interactions[2] are dependent on the activity of myosin-ATPase[4]

Bleb formation can be initiated in two ways: 1) through local rupture of the cortex or 2) through local detachment of the cortex from the plasma membrane.[5] This generates a weak spot through which the cytoplasm flows, leading to the expansion of the bulge of membrane by increasing the surface area through tearing of the membrane from the cortex, during which time, actin levels decrease.[3] The cytoplasmic flow is driven by hydrostatic pressure inside the cell.[6][7]

Blebbing is one of the defined features of apoptosis.[4] During apoptosis (programmed cell death), the cell's cytoskeleton breaks up and causes the membrane to bulge outward.[8] These bulges may separate from the cell, taking a portion of cytoplasm with them, to become known as apoptotic blebs.[9]Phagocytic cells eventually consume these fragments and the components are recycled.

Two types of blebs are recognized in apoptosis. Initially, small surface blebs are formed. During later stages, larger so-called dynamic blebs may appear, which may carry larger organelle fragments such as larger parts of the fragmented apoptotic cell nucleus.[10]

Blebbing also has important functions in other cellular processes, including cell locomotion, cell division, and physical or chemical stresses. Blebs have been seen in cultured cells in certain stages of the cell cycle. These blebs are used for cell locomotion in embryogenesis.[11] The types of blebs vary greatly, including variations in bleb growth rates, size, contents, and actin content. It also plays an important role in all five varieties of necrosis, a generally detrimental process. However, cell organelles do not spread into necrotic blebs.

In 2004, a chemical known as blebbistatin was shown to inhibit the formation of blebs. This agent was discovered in a screen for small molecule inhibitors of nonmuscle myosin IIA and was shown to lower the affinity of myosin with actin,[12][13][14] thus altering the contractile forces that impinge on the cytoskeleton-membrane interface.

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Bleb (cell biology) - Wikipedia

Clinical Cancer Research | Cancer Clinical Research …

Cancer research not only advances the state-of-the-art in cancer treatment, it also provides a source of hope and help to patients for whom other treatments have failed. As a member of the Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center is involved in the discovery of new forms of prevention, diagnosis and treatment. UH Seidman Cancer Center research efforts are focused on "developmental therapeutics" quickly translating scientific findings into the highest quality patient care. Thus, UH Seidman Cancer Center patients are among the first in the nation to benefit from the newest investigative cancer treatmentsmany of which are not available outside a research setting.

Clinical trials are research studies that are used to find better ways to diagnose and treat individuals with cancer. UH Seidman Cancer Center offers more than 300 clinical trialsin most cancer diagnoses and stages of disease.

The Cancer Genetics Programat University Hospitals brings together experts from the Center for Human Genetics and University Hospitals Seidman Cancer Center to help families with a history of breast, colon or pediatric cancers.

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Clinical Cancer Research | Cancer Clinical Research ...