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Human Behavior

Find a hunting pup that is your match – Farm and Dairy

Every hunter dreams of owning the perfect canine companion.

But too often, the dream becomes a nightmare. It happens when the dog and owner arent a good match. Read on.

The right dog with the right owner can make a great team.

Of course, several factors have a place in the equation. Training, conditioning, and planned practice, weigh in but theres one thing that determines the outcome more than anything else.

The hunter and the dog must be a match and that means just any pup wont work. If the dream is to come true, it is important to consider each breed on more than its potential because before Fido can reach his, hunter and canine must bond, a connection that is easy if personalities are similar.

How about a pointer who is bred for the job of finding birds, holding them for a hunter, and fetching downed birds with a soft mouth.

But individuals from many of the pointing breeds, for the most part, come with a built-in desire to hunt big, that is, to cover a lot of real estate in a hurry. Thats perfect for big, open country, but here in the northeast most bird hunters are hunting smaller fields and heavier brush, so maybe a tighter running dog would be a better fit.

But theres more, so much more.

Each breed has potential while each pup within the breed has its own personality, just like hunters. Heres a quick rundown of todays popular hunting breeds for comparison.

The beagle is about as blue-collar as a dog can be. These little guys are the easiest of all breeds to train and hunt. A pup needs only to be exposed to the fields and briars. In time a beagle pup will get a nose full of rabbit and the rest is history.

But he is a hound and the personality of a hound is all about me. Few hounds are great listeners and in a perfect dog world a hound could do well without any human help. A beagle is driven by his nose and thats about all there is to it. It can be taught to sit, come, and do a trick or two but hell perform cuties only if hes not hunting.

The best part about beagles is that they are always happy. Cuss at them if you wish, yell at them if you want, they dont care.

Retrievers are popular with Ohio hunters. For the most part, retrievers, unlike hounds, are people-oriented. Take a Labrador for instance: a dog that wants to be under control, really wants it.

Walk away from a Lab and hell follow. Stop and hell stop. And more, a Lab will constantly look to the boss for instruction. Easy to train, easy to love and as far as personality, a Lab is like a good kid.

Punish a Lab for a misdeed, paddle it, call it names and hell forgive your indiscretion in minutes, maybe seconds. A lab could only be improved if it could walk on two legs and wear a ball cap backward.

Golden retrievers can be a little more reluctant to accept lessons and are a bit more sensitive. Chesapeake Retrievers are outstanding workers, tough as nails and a bit stubborn.

The spaniel breeds are another story. Great hunters, spaniels are compact and quick. They love the hunt and are easy to train. Spaniels like to please, and they can be taught to check in constantly making them a fun hunting companion. Brittanys are pointers and English are flushers. Both tend to be a bit soft and not quick to forgive ill behavior. That is, spaniels can be emotionally damaged by rough treatment and severe reprimands.

German shorthair pointers are right down the middle when it comes to temperament and personality. Theyll run big if encouraged or stay close if instructed. Shorthairs will tolerate about any human behavior and theyll put birds in the basket as well as any dog bred.

But bred-in personality can be toned and groomed by careful training and social interaction. A growing pup will learn from its environment very quickly and once learned, a dogs behavior and imprinted personality is hard to change.

A trainer who is calm and soft-spoken will most often raise a hunting dog that is relaxed and responsive to voice commands. On the other hand, a pup that is surrounded by loud, harsh, and demanding instruction will react accordingly. That pup will grow to be nervous and anxious to be out of earshot. Think about it.

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Find a hunting pup that is your match - Farm and Dairy

Human Behavior

Week in review: How to avoid lateral phishing, what’s the right time to red team? – Help Net Security

Heres an overview of some of last weeks most interesting news and articles:

Your suppliers BEC problem is your BEC problemBEC scammers dont care what business the potential targets are in: all they care is that they have money that can be stolen preferably lots of it and that they have vulnerabilities they can exploit to pull off the heist.

PayPal becomes phishers favorite brand, Office 365 phishing techniques evolvePayPal has overtaken Microsoft to claim the number one ranking for phishers favorites for the first time. Netflix was not far behind as the streaming giant moved up to the third spot with a 14.1 percent QoQ and 73.7 percent YoY growth in unique phishing URLs, according to Vade Secure.

Automated systems: Flag smarter, not everythingCybersecurity professionals are constantly receiving a large number of security alerts from these automated systems most of which are near-to-useless information. As opposed to flagging potential incidents in the network, these systems are flagging alerts every time it encounters anything any anomaly, any intrusion attempt, any suspicious code, any unusual data movement.

Intel releases updates to plug TPM-FAIL flaws, foil ZombieLoad v2 attacksIntels Patch Tuesday releases are rarely so salient as those pushed out this month: the semiconductor chip manufacturer has patched a slew of high-profile vulnerabilities in their chips and drivers.

Speeding MTTR when a third-party cloud service is attackedWe all know you cant stop every malicious attack. Even more troublesome is when an externally sourced element in the cloud engaged as part of your infrastructure is hit and it impacts customers using your digital service.

Enterprise cybersecurity in the Asia-Pacific regionAlmost one in five business organizations in the Asia-Pacific (APAC) region experienced more than six security breaches in the past two years, a new ESET enterprise cybersecurity survey has revealed.

Whitepaper: Cybersecurity is improving, but is it enough?Digital transformation initiatives are pushing many organizations into unfamiliar territory that they are not equipped to protect.

Attack tools and techniques used by major ransomware familiesRansomware tries to slip unnoticed past security controls by abusing trusted and legitimate processes, and then harnesses internal systems to encrypt the maximum number of files and disable backup and recovery processes before an IT security team catches up, according to a new Sophos report.

GitHub Security Lab aims to make open source software more secureOur team will lead by example, dedicating full-time resources to finding and reporting vulnerabilities in critical open source projects, said Jamie Cool, VP of Product Management, Security at GitHub.

Believe the hype, but control the threat: Reducing the risk of ransomwareRansomware is becoming an epidemic for any collection or repository of data. Each day the attacks seem to be getting larger and more lucrative for cybercriminals. According to Europols annual report, the Internet Organised Crime Threat Assessment (IOCTA), file-encrypting malware attacks could become far more destructive as cybercriminals change their tactics.

When is the right time to red team?Red teaming has become increasingly popular in recent years as firms become more aware of the threats they are facing. However, because it is often thought of as an extension of pen testing, we often find that businesses are keen to jump straight into red teaming before they are ready for it.

Product showcase: SpyCloud Active Directory GuardianSpyCloud Active Directory is a browser-based application that runs locally and easily installs in minutes. It can be custom-configured to scan automatically or on-demand.

The password reuse problem is a ticking time bombPasswords, like email, seem future proof; but they are also the source of many cybersecurity problems. Key drivers of these issues are human behavior and the desire for convenience, which results in password reuse across multiple accounts.

The FBI multi-factor authentication notification that should have never beenWhile reviewing the recent Private Industry Notification from the FBI about using social engineering and technical attacks to circumvent multi-factor authentication, I was floored at how each of these account takeover scenarios seemed completely preventable.

Fraud rates increasing as criminals become more sophisticatedFraud rates have been skyrocketing, with 90 voice channel attacks occurring every minute in the U.S., Pindrop reveals.

Lateral phishing makes for dangerous waters, heres how you can avoid getting caught in the netAs companies and consumers have become more aware of phishing, hackers have refined their techniques and are now launching a more advanced form of attack known as lateral phishing. This technique is highly convincing and, consequently, highly effective.

Attackers continue to leverage greater levels of social engineering and sophisticationDespite a nearly four-month absence, the return of Emotet within the last two weeks of September accounted for nearly 12 percent of all malicious email samples in Q3, delivering millions of messages with malicious URLs or attachments, Proofpoint found.

November 2019 Patch Tuesday: Actively exploited IE zero-day fixedNovember 2019 Patch Tuesday comes with patches for an IE zero-day exploited by attackers in the wild and four Hyper-V escapes.

Download: Internal compliance assessment templatesThe Comprehensive Security Guide provides security executives with a single document that gathers standardized and easy to use templates of all main compliance frameworks: PCI-DSS, HIPAA, NIST Cyber Security Framework and GDPR.

5,183 breaches from the first nine months of 2019 exposed 7.9 billion recordsAccording to Risk Based Securitys Q3 2019 Data Breach QuickView Report, the total number of breaches was up 33.3% compared to Q3 2018, with 5,183 breaches reported in the first nine months of 2019.

New infosec products of the week: November 15, 2019A rundown of infosec products released last week.

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Week in review: How to avoid lateral phishing, what's the right time to red team? - Help Net Security

Human Behavior

Taraji P Henson on how she deals with depression: ‘You just have to find what works for you’ – Channel 24

10:29 15/11/2019 Mahlohonolo Magadla

Cape Town - This year Empire actress Taraji P Henson has been very vocal about her battle with depression and anxiety and now she has shared how she tries to get a handle on it.

Speaking to BET at a Kinder Bueno pop-up in New York recently, the 49-year-old actress opened up about her relationship with fianc Kelvin Hayden, her holiday plans, as well as how she deals with depression.

"When I have moments when I feel the darkness creeping in, that's what I like to call it, I have friends that I can call on that, that'll pull me out of it. Sometimes I'll find it hard to motivate myself to work out. I have a friend I can call that will come make me get up and go work out. I meditate. I am into aroma therapy. Im into sound therapy. So I play Tibetan music singing bowls and that helps a lot," she told the publication.

READ MORE:Taraji P Henson just shared the most incredible snaps of her 49th birthday party

Although the actress says her friends pull her out of the dark place she sometimes finds herself in, she says having a therapist is also important as friends can be biased.

"You just have to find what works for you. You know, you should absolutely seek a therapist. Your friends are not your therapists. They are very biased, and they have stakes involved in you. So sometimes their opinion can be skewed a bit. So that's why it's important to seek a professional, someone who studies human behavior and the human mind, she said.

Speaking to Variety earlier this year, the actress revealed that she visits her therapist regularly but had to keep changing therapists before finding the right one.

"Going and talking to all these different therapists, thats a craft. Youve got to keep going until you find the right one. Its like a relationship. Ive got to feel comfortable because thats the only way Im going to keep coming back to you. To keep dealing with this ugly stuff, I have to feel totally safe," she explained.

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Taraji P Henson on how she deals with depression: 'You just have to find what works for you' - Channel 24

Embryology

I believe that life starts at conception – Palatinate

By Pip Murrison & Natasha Mosheim

Profile speaks to President of Students for Life Durham Jolle Lucas about her newly ratified society and the pro-life movement in Durham. An interview with President of Durham Students for Abortion Access can be found here.

Why are you pro-life?

I grew up in a Christian home. It is kind of assumed in that tradition that you are pro-life because we believe that humans are incredibly valuable, that life is a gift from God. But when I was in high school one of my friends asked me the hard question. She said, Well what would you do if a girl was raped or something? And I hadnt thought about that. I went home and I asked my mum that question. My mum just started crying and she looked at me and said well obviously thats horrendous and thats awful, but we dont kill children for the sins of their fathers. We are actually fighting for two victims, we are fighting for a woman and her baby, who were both hurt by someone who was abusive. I think because I heard that emotional, kind response, I became pro-life, it helped cement that.

Do you think that abortion will be abolished worldwide in our lifetime?

I hope that it will be abolished in our lifetime. I would really like to see women given more options, and the abortion numbers to decrease. When abortion was passed in both the UK and the US, especially in the US, the tagline was safe, legal and rare right. Well over 200,000 abortions in the UK is not rare, especially when upwards of 90% of those abortions are not because of health of the mother, they are not because of rape, because of a deadly problem or the foetus or anything like that, they are simply because of inconvenience.

Is abortion unacceptable in cases of rape?

I believe in embryology that life starts at conception. I believe that every human deserves human rights that includes the child. The woman who was raped, her body was violated by the rapist. When you choose abortion, you are also violating the life of the unborn child right, its a similar kind of crime just in a different way, I think that both are wrong. That doesnt mean that I dont have compassion, I think that rapists should be put behind bars at the very least. But I dont think that having an abortion would fix rape. I have done studies on post-abortion counselling and things like that, and its so important and vital that we understand how many women are suffering from post-abortion trauma. If a woman in a normal situation chooses to have an abortion and she suffers from post-abortion trauma, then you go to the woman who is already suffering from the trauma of rape and then add post-abortion trauma on top of that. Why would we want to add to the problem? I was violated, then I tried to get rid of the problem, so I violated and ended up killing another person. I just dont see abortion even in cases of rape as consistent or ultimately really caring, and nothing is going to undo it. We have to find the way thats going to create the least amount of trauma.

Is it ever okay to have an abortion? Even if mothers life at stake?

Pro-Lifers want to save as many lives as possible, hopefully mother and child but if it is a situation where we have to do something as if you do nothing the woman and the child will die, in that case we chose the operation that will save the most lives.

Many would argue that the right to choose abortion is a human right, how would you respond to that?

Some would argue its their human right. I would think that its not consistent and not correct because then youre disregarding the human right of the child. The child inside your body is not your body. Thats a separate human. No woman has two heads or two hearts. Its a separate body. And no person should be able to decide who is valuable and not. These children are just as valuable. But the only difference is somebody decided that they were valuable or not. I think we get into really really sticky territory as humans, when we start deciding that because someone is smaller than us, less capable than us, less able than us, maybe looks a little different than us, that we have the right to decide that they are not human. Because thats how we get the holocaust, thats how we get slavery, thats how we get things like racism and ableism and whatever else you want to call it. If we say that every person is valuable, then we have to include the unborn in that.

Donald Trump says he is Pro-Life but with caveats i.e. abortion is acceptable in cases of rape and incest. Obviously, you dont agree with the caveats, but do you support Trump, based on his Pro-Life stance?

Ive been really surprised with how pro-life President Trump has been, because I was concerned, and thought maybe hes just saying that to get the Republican vote, who knows. Im not one of those people that will say we have to agree on every single point in order for you to get my vote but Pro-Life was the main one and I think anything we can do to protect women and reduce abortion I think is a good thing.

Why do pro-life activists struggle to make their voices heard over the pro-choice campaign?

I think it is because its swept in with other things in Conservatism. Not because Im ashamed, but because I would be scared. Oftentimes there is that silent majority where you have one small group of people yelling really really loudly and everyone else is like I have my voice but I dont need to shout. That can be the case with people that are pro-life. If you say you are pro-life in the wrong crowd, youll get hate, youll get bullied, people will make fun of you and they will make assumptions about you and before you even have a chance to say anything about I care for women or that I spend a lot of time wanting to champion for women and things like that, theyll say you racist, bigoted, women hater, anti-feminist, Nazi. And youre just like, well youve already decided who I am, what more is there to say? So I think that that causes a lot of people to want to be silent.

You talk a lot about how being pro-life for you is tied up with female empowerment. Would you describe yourself as a feminist?

I generally dont use the term feminist because of what the feminist lobby stands for today, I dont agree with them on a lot of things. I dont agree with third wave feminism. I would agree with first and probably second wave feminism. Actually the first feminists were all pro-life. They were huge champions for women. A lot of what feminism is doing today is really just trying to turn women into men. I just dont understand that. What the original feminists were trying to do were to say we can be women, we can love being women and have jobs and vote and we dont have to become men to do that. That, to me, is what being feminist is and what I would like feminism to return to. To say we dont have to be men to be valuable people.

Do you think that the scare factor of having an unplanned pregnancy whilst at university drives students towards abortion? How would you advise someone who has an unplanned pregnancy?

I would say absolutely. Not every woman is the same, for some women it would not matter what the options were, they would just want the abortion. But for the majority of women I have spoken to, when I have said if were to get rid of everything that would be impeding you having this baby, be it funds or a house or a jobs or a boyfriend or whatever, they most often would say yes I would want this baby. I see a massive problem there, that if they had the support they would want their baby and our response is too bad, we will just give you an abortion any way. So I would encourage them to think 10, 30, 40 years down the road, and you look back and can say I made the right choice, the best and most loving choice for me and for this baby. I think all to often we think abortion is the undo button. What we dont talk about is how emotionally difficult it is to end the life of a child, to live with that, we live in a culture that tells women if you chose an abortion you should not feel bad about it, you should feel empowered and you should get over it.

Disclaimer: All views and research cited above are those of the interviewee and are not necessarily reflective of Palatinate.

Image by Jolle Lucas

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I believe that life starts at conception - Palatinate

Cell Biology

Bayer and Dewpoint Therapeutics Ink $100 Million Research Partnership – BioSpace

Germany-based Bayer and Dewpoint Therapeutics, located in Boston, announced a research deal that could hit $100 million. The research pact will leverage Dewpoints biomolecular condensates technology platform and Bayers small molecule compound library to identify and develop new therapies for cardiovascular and gynecological diseases.

Biomolecular condensates are droplet-like membrane-less organelles that form in a dynamic fashion with many proteins in order to function within cells. About 80% of proteins in humans are considered unreachable with small molecule drugs. The companies believe that with Dewpoints platform, they will broaden the reach of small molecule therapeutics, identifying new drug targets.

As we continue to broaden our capabilities in Research & Development, the collaboration with Dewpoint gives us access to breakthrough innovation potential, said Joerg Moeller, member of Bayers executive committees Pharmaceuticals Division and head of Research and Development. New analytic tools and a growing understanding of biomolecular condensates could provide new insights into cellular functions that previously have not been considered by scientists in drug development, enabling us to identify novel pharmacological targets for future therapies.

Under the terms of the deal, Bayer picks up an option to exclusively license a specific number of novel therapeutics that come out of the research. In addition to access to Bayers small molecule compound library, it brings R&D capabilities including high throughput screening and medicinal chemistry. No other financial details were disclosed. Nor was the length of the pact.

In January 2019, Bayer participated in Dewpoints $60 million Series A financing via the Leaps by Bayer investment unit.

Dewpoint has locations in Boston and Dresden, Germany. Part of the agreement is to expand Dewpoints presence in Germany outside of Dresden.

This partnership is an exciting opportunity to advance treatments for diseases that have long evaded the industry, said Amir Nashat, Dewpoints chief executive officer. We look forward to combining Bayers expertise in chemistry and drug development and Dewpoints novel platform and insights into the role of biomolecular condensates in disease. We also look forward to working closely with Bayer to expand our capabilities in Germany and put the local biotech ecosystem at the forefront of this important and emerging area.

Dewpoint was founded by Anthony Hyman of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, and Richard Young of the Whitehead Institute in Cambridge, Massachusetts. At the Series A, additional investors besides Bayer included founding investor Polaris Partners, Samsara BioCapital, 6 Dimensions Capital, EcoR1 Capital, and Alexandria Venture Investments.

Although the research partnership between Dewpoint and Bayer will focus on cardiovascular and gynecologic diseases, numerous other diseases are affected by condensates including cancer, neurodegenerative disorders, immunology and virology.

At the time of the launch, Hyman said, Insights into biomolecular condensates could provide answers to fundamental mysteries in biology, and we are eager to begin using these to discover new therapeutic approaches to diseases.

The companys scientific advisors include Simon Alberti, professor and chair of Cellular Biochemistry at the Technical University Dresden; Arup Chakraborty, Robert T. Haslam Professor of Chemical Engineering and Professor of Physics and Chemistry at MIT; Bradley Hyman, John B. Penny, Jr. Professor of Neurology at Harvard Medical School and Director of the Alzheimers unit at Mass General Institute for Neurological Disease; Rudolf Jaenisch, Whitehead Institute Founding Member and Professor of Biology at MIT; Robert Langer, David H. Koch Institute Professor at MIT; Timothy Mitchison, Hasib Sabbagh Professor of Systems Biology at Harvard Medical School and Director of the Harvard Therapeutics Innovation Hub; and Rohit Pappu, Edwin H. Murty Professor of Engineering in the Department of Biomedical Engineering and Director of the Center for the Science & Engineering of Living Systems at Washington University in St. Louis.

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Bayer and Dewpoint Therapeutics Ink $100 Million Research Partnership - BioSpace

Cell Biology

Scientists Discover How the Molecule-sorting Station in Our Cells is Formed and Maintained – Nature World News

Nov 16, 2019 08:55 AM EST

The cells in our body are workshops that continuously operate to produce and process substances to keep us going. When a substance enters a cell for processing, it is surrounded by a portion of the cell's outer membrane to form a sac. The sac then buds off into the cell and becomes a vesicle containing the substance. This ingestion of substances by the cell is called endocytosis. The vesicle is then quickly merged with an endosome, an organelle also frequently referred to as a 'sorting station'. From the endosome, the substance is either recycled back to the cell membrane (for exiting the cell) or forwarded to a lysosome--a cell organelle containing enzymes for the breakdown of substances--for degradation. The substances entering a cell--and thereby an endosome--could be nutrients or signal molecules for processing, or even pathogenic viruses which can cause disease. It is therefore extremely important to fully understand the molecular basis of how endosomes are formed and maintained.

It is generally accepted by scholars in the field that these endosomes are formed and maintained by a mechanism in which vesicles travelling from the cell membrane constantly fuse into them. But in a recent study published inCommunications Biology, a group of scientists from Japan and Austria, led by Prof Jiro Toshima from the Tokyo University of Science, claims that vesicles transported out of the Golgi--another crucial cell organelle--and not those from the cell membrane are more important for the formation and maintenance of endosomes. "We used our research to show that endocytic vesicle internalization is not essential, but that vesicle transport from the trans-Golgi network [TGN; the Golgi] is crucial," the team of scientists--comprising Makoto Nagano (Tokyo University of Science), Junko Y. Toshima (Tokyo University of Technology), Daria Elisabeth Siekhaus (Institute of Science and Technology, Austria) and Jiro Toshima--says.

They base their claim on the results of a series of experiments, involving the introduction of mutations or drugs (two drugs called Brefeldin A and Monensin) into yeast cells, to clarify the mechanism of endosome formation. As part of the experiments, they first used mutant yeast strains, which harbor mutations that cause defects in the endocytosis process; that is, they caused the ingestion of substances at the cell membrane to be hampered. Upon observation of the mutated cells, they found that the protein that mediates the formation of endosomes, Rab5, localized at the endosomes as per usual, leading to normal endosome formation.

They then introduced the two drugs into yeast cells to inhibit the transport of specific protein-containing vesicles from the Golgi. By doing so, they expected to find out whether these vesicles are required for the formation and maintenance of endosomes. They saw that smaller amounts of Rab5 localized on the endosomes, hampering endosome formation.

With further similar experiments, Prof Toshima and group saw that certain proteins, which are either resident in the Golgi or recruited to it, are transported from the Golgi to the endosomes where they activate Rab5 and spark the formation of endosomes. Deleting or deactivating the genes crucial to the transport of these proteins from the Golgi ultimately affects endosome formation.

Thus, considering all of these results together, it appears that endocytosis is not necessary for endosome formation and maintenance, but vesicle transport form the Golgi is. "Our results provide a different view of endosome formation and identify the TGN as a critical location for optimal maintenance and functioning of endosomes," Prof Toshima says.

Given that endosomes are essential to the functioning of the cell and, by extension, the organism, understanding the mechanism of its upkeep is important. The results of this compelling study reveal but a fraction of this mechanism and much remains to be discovered. Even so, this advancement in the knowledge of one of the core pathways by which cells process substances in the body can lead to enhanced comprehension of the molecular basis of diseases that involve defective endosomes, thereby leading to better treatments for such diseases.

2018 NatureWorldNews.com All rights reserved. Do not reproduce without permission.

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Scientists Discover How the Molecule-sorting Station in Our Cells is Formed and Maintained - Nature World News

Cell Biology

Taking Their Time Together – Harvard Medical School

Husband and wife Hemsley and Lunadel Matthews will retire on November 22 after a combined 61 years of service in the Harvard Medical School Department of Cell Biology.

Hemsley started working at HMS in 1986 as a lab assistant and has been a lab technician group leader since 2012, cleaning and sterilizing the hundreds of tubes, beakers, flasks and other glassware the cell biology labs rely on each day. Lunadel joined Hemsley at HMS in 1992 as a lab aide, and for the past 20 years she has worked as a lab technician, preparing petri dishes, culture media and other materials for experiments.

Get more HMS news here

Lunadel starts her workday at 5:30 in the morning. Its a habit she developed when their children were young. Lunadel would arrive before the sun was up and would begin prepping that days materials for the labs while Hemsley got the children ready for school. Then Lunadel could leave in the afternoon to be home when their children got out of school while Hemsley worked into the evening.

Over their 45 years of marriage and almost 30 years working together at HMS, the couple have made sure to keep their professional and personal lives separate.

We leave Harvard here, said Lunadel. When you go home, you have the children, you have grandkids, you have to give them the best of you. If youre bringing your problems from here home, its not good.

In their retirement, they plan to spend half the year in Boston, where their five adult children and 10 grandchildren live, and half the year in their native Jamaica. When they return to Jamaica, it will be to a life very different from the one they left behind more than four decades ago.

The couple owns two houses in Jamaica, one in Kingston and one in the country, where they keep a small farm with goats, cows and pigs. Asked if they plan to get more animals now that theyll be spending more time in Jamaica, Lunadel shook her head no. Im trying to tone him down, she said, referring to her husband.

Im from the city, so I dont know much about farming, said Hemsley. But when Im out in the air, I just get excited.

After so many years working in cell biology, the Matthews'absence will be felt in the department.

Lunadel and Hemsley are great to work with, said Janelle Frederick, administrative coordinator in cell biology. Theyre conscientious, friendly and easy-going. They take pride in their work each and every day, and thats hard to replicate.

Julie Huang, the departments director of research administration, agreed.

Very few in our department can recall a time that Lunadel and Hemsley werent here. Theyve been wonderful members of our community, and well miss them both, she said.

The couple say they will miss the work and their Harvard colleagues, but theyre excited for this new chapter in their life. In addition to spending more time in Jamaica, they plan to travel, first to Africa, then perhaps Paris, London and anywhere else that strikes their fancy.

Im working from 12 years old, said Hemsley. When I left Jamaica at 23, I said, When I come to America, Im not staying until Im 70.

He will turn70 in January.

So, Ill be 70 in Jamaica, he said.

Its time, echoed Lunadel. Its time for us to do something for ourselves now.

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Taking Their Time Together - Harvard Medical School

Cell Biology

New Questions About Basic Cell Biology Pdf Answered and Why You Must Read Every Word of This Report – Streetsblog Texas

Essential cell biology pdf is just one of the well-known and best-selling book of Cell Biology. In this time the total amount of DNA doubles per cell. In this time the total amount of DNA per cell doubles.

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Appendages Bacteria could have these appendages. They are capable of synthesizing new proteins, which are essential for the modulation and maintenance of cellular activities. Mitochondrial cells divide using their very own circular strand of DNA and because of this there may be several mitochondria in 1 cell.

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New Questions About Basic Cell Biology Pdf Answered and Why You Must Read Every Word of This Report - Streetsblog Texas

Cell Biology

A Community Day on the Opioid Addiction Crisis – Touro College News

An International Crisis and Local Crisis and Epidemic in Our Community: New Models of Prevention, Treatment, and Recovery

COMMUNITY DAY PROGRAM AGENDA

Steven Huberman, PhDDean, Touro College Graduate School of Social Work

Alan Kadish, MDPresident, Touro College and University System

Arlene Gonzalez-Sanchez, MS, LMSWNew York State Commissioner, Office of Addiction Services and Support (OASAS)Combating the Opioid Crisis in New York State: A Community Effort.

Daniel Rosa, MDBoard Certified Internist, Addiction Medicine Specialist, and Senior Medical Director, Acacia NetworkThe Neurobiology of Addiction.

James Hollywood, LCSWVice President of Residential Treatment, Samaritan Daytop VillageEvidence Based Treatment and Harm Reduction / What Social Workers Need to Know.

Q&A session and kosher dinner will follow keynote addresses

New York State Commissioner Arlene Gonzalez-Sanchez, MS, LMSW Office of Addiction Services and Support

Commissioner Arlene Gonzalez-Sanchez, MS, LMSW, was appointed New York State Commissioner of the Office of Addiction Services and Support (NYS OASAS) by Governor Andrew M. Cuomo on Jan. 3, 2011.

Commissioner Gonzalez-Sanchez has more than 30 years of experience in the fields of behavioral health services administration, health policy development, and medical research. Under the Commissioners leadership, OASAS works to realize her vision for transforming the current system of care for individuals with substance use disorders into a comprehensive, patient-centered and family-focused system. Commissioner Gonzalez-Sanchez serves on the Governors Medicaid Redesign Team (MRT) Behavioral Health Subcommittee. She is co-chair of the States Behavioral Health Services Advisory Council and a co-chair of the Responsible Play Partnership which addresses problem gambling in New York State.

On a national level, Commissioner Gonzalez-Sanchez serves as the First Vice President of the National Association of State Alcohol and Drug Abuse Directors (NASADAD) Board.

Commissioner Gonzalez-Sanchez holds a Master of Social Work degree in Administration and Community Organization from the Hunter College School of Social Work; and a Masters of Science degree in Cell Biology and a Bachelor of Science degree in Biology; both from Fordham University. She is a Licensed Master Social Worker.

Daniel Rosa, MDBoard Certified Internist, Addiction Medicine Specialist, and Senior Medical Director, Acacia Network

Dr. Daniel Rosa is an internal medicine specialist in the Bronx, New York where he was born and raised. He currently serves as the Senior Medical Director of Acacia Network (Clay Avenue Division), having previously been the Acting Chief Medical Officer. He also practices Emergency Medicine at Penn (Philadelphia VA Medical Center) on the weekends. He is a product of the public school system of NYC (Bronx) and furthered his education by graduating from Fordham University and then was accepted to the Harvard Medical School where after graduating he completed his residency in NYC. He has over 34 years of diverse experience in Internal Medicine, Addiction Medicine, HIV Medicine, and has been a member of the American College of Emergency Physicians (ACEP) for over 20 years. He also teaches the Advance Traumatic Life Support Course three times a year at the Westchester Medical Center and serves as facilitator for the review course for the California Society of Addiction Medicine (CSAM). Dr. Rosa also cooperates with other doctors and physicians in medical groups, including the Puerto Rican Organization To Motivate Enlighten And Serve Addicts Inc.

James Hollywood, LCSWVice President of Residential Treatment, Samaritan Daytop Village / Adjunct Professor Touro College

James Hollywood, LCSW, is Vice President of Residential Treatment and oversees the organizations 12 residential substance use disorder treatment programs, with over 950 beds and serving 3,000 clients each year. Over the course of his tenure in Samaritan Daytop Village, Mr. Hollywood led efforts to implement and sustain evidence based treatments to address addiction and co-occurring disorders that includes the use of psychometrically valid assessment tools and specific interventions to address the needs of those in residential treatment. Mr. Hollywood led the development and implementation of new residential clinical and administrative practices needed to create the new model of residential treatment, which include stabilization, rehabilitation and reintegration element of care. In addition to Residential Services, Mr. Hollywood manages two Criminal Justice programs: NYC DOC SMART Program, and Jails to Jobs. Mr. Hollywood brings more than 30 years of experience working in the fields of substance use, mental health and homeless services. Mr. Hollywood holds a BA in Sociology from St. John's University and graduated with an MSW from Hunter College School of Social Work.

Read the rest here:
A Community Day on the Opioid Addiction Crisis - Touro College News

Cell Biology

Study uncovers how the molecule-sorting station in our cells is formed and maintained – News-Medical.net

The cells in our body are workshops that continuously operate to produce and process substances to keep us going. When a substance enters a cell for processing, it is surrounded by a portion of the cell's outer membrane to form a sac. The sac then buds off into the cell and becomes a vesicle containing the substance. This ingestion of substances by the cell is called endocytosis. The vesicle is then quickly merged with an endosome, an organelle also frequently referred to as a 'sorting station'. From the endosome, the substance is either recycled back to the cell membrane (for exiting the cell) or forwarded to a lysosome--a cell organelle containing enzymes for the breakdown of substances--for degradation. The substances entering a cell--and thereby an endosome--could be nutrients or signal molecules for processing, or even pathogenic viruses which can cause disease. It is therefore extremely important to fully understand the molecular basis of how endosomes are formed and maintained.

It is generally accepted by scholars in the field that these endosomes are formed and maintained by a mechanism in which vesicles traveling from the cell membrane constantly fuse into them. But in a recent study published in Communications Biology, a group of scientists from Japan and Austria, led by Prof Jiro Toshima from the Tokyo University of Science, claims that vesicles transported out of the Golgi--another crucial cell organelle--and not those from the cell membrane are more important for the formation and maintenance of endosomes. "We used our research to show that endocytic vesicle internalization is not essential, but that vesicle transport from the trans-Golgi network [TGN; the Golgi] is crucial," the team of scientists--comprising Makoto Nagano (Tokyo University of Science), Junko Y. Toshima (Tokyo University of Technology), Daria Elisabeth Siekhaus (Institute of Science and Technology, Austria) and Jiro Toshima--says.

They base their claim on the results of a series of experiments, involving the introduction of mutations or drugs (two drugs called Brefeldin A and Monensin) into yeast cells, to clarify the mechanism of endosome formation. As part of the experiments, they first used mutant yeast strains, which harbor mutations that cause defects in the endocytosis process; that is, they caused the ingestion of substances at the cell membrane to be hampered. Upon observation of the mutated cells, they found that the protein that mediates the formation of endosomes, Rab5, localized at the endosomes as per usual, leading to normal endosome formation.

They then introduced the two drugs into yeast cells to inhibit the transport of specific protein-containing vesicles from the Golgi. By doing so, they expected to find out whether these vesicles are required for the formation and maintenance of endosomes. They saw that smaller amounts of Rab5 localized on the endosomes, hampering endosome formation.

With further similar experiments, Prof Toshima and group saw that certain proteins, which are either resident in the Golgi or recruited to it, are transported from the Golgi to the endosomes where they activate Rab5 and spark the formation of endosomes. Deleting or deactivating the genes crucial to the transport of these proteins from the Golgi ultimately affects endosome formation.

Thus, considering all of these results together, it appears that endocytosis is not necessary for endosome formation and maintenance, but vesicle transport form the Golgi is.

Our results provide a different view of endosome formation and identify the TGN as a critical location for optimal maintenance and functioning of endosomes."

Prof Jiro Toshima, Tokyo University of Science

Given that endosomes are essential to the functioning of the cell and, by extension, the organism, understanding the mechanism of its upkeep is important. The results of this compelling study reveal but a fraction of this mechanism and much remains to be discovered. Even so, this advancement in the knowledge of one of the core pathways by which cells process substances in the body can lead to enhanced comprehension of the molecular basis of diseases that involve defective endosomes, thereby leading to better treatments for such diseases.

Source:

Journal reference:

Nagano, M., et al. (2019) Rab5-mediated endosome formation is regulated at the trans-Golgi network. Communications Biology. doi.org/10.1038/s42003-019-0670-5.

Link:
Study uncovers how the molecule-sorting station in our cells is formed and maintained - News-Medical.net