All posts by medical

New way to thwart HIV infection at early stages – News-Medical.net

1.7 million. That's how many people are infected with the human immunodeficiency virus (HIV) each year worldwide. 1.7 million people who are condemned to lifelong antiretroviral therapy (ART) or risk developing fatal AIDS . Out of the 37.9 million people living with HIV (PLWH), 22.3 million have access to ART, allowing them to have an almost normal lifespan. Unfortunately, however, the medications only go so far: they don't reach the cells where the virus lies dormant for years. Moreover, potential long-term adverse effects of these medications remain unknown.

Still, HIV research has been making steady strides to help the large number of PLWH. HIV laboratories around the globe are trying to unlock the "secrets" of the virus and find its weak spots in order to prevent or cure the infection. At the Montreal Clinical Research Institute (IRCM), scientists ric A. Cohen and Tram NQ Pham have recently identified a way to thwart HIV infection at its very early stages. Their discovery is the subject of an article in the scientific journal Cell Reports.

Contrary to popular belief, HIV is not so easily transmitted. We are studying the window of vulnerability of the virus, meaning the moments in the infection process when it could be weakened or attacked. We focused on the very early stages following viral invasion.

ric Cohen, director of the Human Retrovirology Research Unit at the IRCM and a virology professor in the Department of Microbiology, Infectious Diseases and Immunology at Universit de Montral

Once transmitted, HIV does not immediately spread through the body. It initially has to multiply locally, mainly in the genital tissues. It is only after this initial, local expansion that the virus spreads. This localized expansion offers a very brief window of vulnerability before the virus efficiently establishes a systemic infection.

The immune response is like an armed struggle: an enemy infiltrates and the body defends itself. Viruses are the intruders, and white blood cells are soldiers trying to hold down the fort. The white blood cells are equipped with their own "infantry units": lymphocytes, phagocytes, granulocytes and others. The phagocyte group has an even more specialized unit known as 'plasmacytoid dendritic cells' (PDCs). These small, round-shaped cells patrol the body, specializing in both pathogen detection and antiviral response orchestration. In other words, they are the whistleblowers, the ones through which the entire defence process is set into motion. When they detect a threat, they change shape and develop protuberances called dendrites. "Most importantly, they start producing large amounts of interferon, a protein that triggers a state of infection resistance in other cells," Cohen explained.

As its name implies, HIV preferentially targets the immune system: it attacks and weakens the body's own defences, and the infected person becomes susceptible to the slightest infection. As soon as it arrives, HIV gets PDCs out of the way and prevents them from sounding the alarm. "The virus doesn't seem to kill them directly, but it makes them disappear in a way that is still not understood," said Pham, the senior research associate in the Human Retrovirology Research Unit. "The loss of PDCs from both the infection site and throughout the body helps establish the infection."

"Given what HIV does to PDCs, we wondered what would happen if we boosted PDC levels and their function both prior to and during infection," said Cohen. To test this, the scientists used a special protein known as Flt3 receptor ligand to stimulate the production of PDCs from the bone marrow of humanized mice. These rodents are engineered to have a human immune system in place of the mouse's own machinery. Consequently, in an infected humanized mouse, HIV behaves as it otherwise would in a human host.

Administration of this special protein maintained high levels of PDCs in these mice and produced some striking results: 1) the initial number of infected mice was reduced; 2) the time it took for the virus to be detectable in the blood was lengthened; and 3) the amount of virus in the blood, also known as viremia, was significantly reduced. "We observed up to a 100-fold decrease in viremia," Pham noted. "In other words, the initial infection is suppressed by maintaining a high level of PDCs."

This seminal work also showed that the injection of the Flt3 receptor ligand not only increased PDC abundance, but also boosted their ability to detect the virus and produce interferon following its detection.

Of course, HIV infection normally goes unnoticed and by the time the viremia is detectable, it is a little too late. In this context, the discovery by Cohen and Pham is highly important in terms of prevention and a potential cure. "These new findings will be crucial in the design of an HIV vaccine, which is basically aimed at teaching the immune system to defend itself by introducing it to a weakened form of the virus," said Cohen. "We can now focus on PDCs in order to control the seeding and expansion of the virus at the early stage of infection."

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New way to thwart HIV infection at early stages - News-Medical.net

Gossamer Bio Announces Participation in Upcoming Investor Conferences – Yahoo Finance

SAN DIEGO--(BUSINESS WIRE)--

Gossamer Bio, Inc. (GOSS), a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, today announced that members of the management team will participate in the following investor conferences:

A live webcast of the presentations will be available on the Events and Presentations page in the Investors section of the companys website at https://ir.gossamerbio.com. A replay of the webcast will be archived on the companys website for 90 days following the presentation.

About Gossamer Bio

Gossamer Bio is a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology. Its goal is to be an industry leader in each of these therapeutic areas and to enhance and extend the lives of patients suffering from such diseases.

View source version on businesswire.com: https://www.businesswire.com/news/home/20191126005147/en/

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Gossamer Bio Announces Participation in Upcoming Investor Conferences - Yahoo Finance

First-Ever Measurement of a Blue Whale’s Heartbeat Reveals Surprising Extremes – ScienceAlert

WASHINGTON (Reuters) - Using a bright orange electrocardiogram machine attached with suction cups to the body of a blue whale, scientists for the first time have measured the heart rate of the world's largest creature and came away with insight about the renowned behemoth's physiology.

The blue whale, which can reach up to 100 feet (30 meters) long and weigh 200 tons, lowers its heart rate to as little as two beats per minute as it lunges under the ocean surface for food, researchers said on Monday.

The maximum heart rate they recorded was 37 beats per minute after the air-breathing marine mammal returned to the surface from a foraging dive.

"The blue whale is the largest animal of all-time and has long fascinated biologists," said Stanford University marine biologist Jeremy Goldbogen, who led the study published in the journal Proceedings of the National Academy of Sciences.

"In particular, new measures of vital rates and physiological rates help us understand how animals work at the upper extreme of body mass," Goldbogen added. "What is life like and what is the pace of life at such a large scale?"

Generally speaking, the larger the animal, the lower the heart rate, minimizing the amount of work the heart does while distributing blood around the body.

The normal human resting heart rate ranges from about 60 to 100 beats per minute and tops out at about 200 during athletic exertion. The smallest mammals, shrews, have heart rates upwards of a thousand beats per minute.

The researchers created a tag device, encased in an orange plastic shell, that contained an electrocardiogram machine to monitor a whale's heart rhythm swimming in the open ocean. The device had four suction cups to enable them to attach it to the whale non-invasively.

The researchers obtained nine hours of data from an adult male whale about 72 feet (22 meters) long encountered in Monterey Bay off California's coast.

"First we have to find a blue whale, which can be very difficult because these animals range across vast swaths of the open ocean. By combining many years of field experience and some luck, we position a small, rigid-hulled, inflatable boat on the whale's left side," Goldbogen said.

"We then have to deploy the tag using a six-meter (20-foot) long carbon-fiber pole. As the whale surfaces to breathe, we tag the whale in a location that we think is closest to the heart: just behind the whale's left flipper," Goldbogen added.

Baleen whales such as blue whales, despite their immense size, feed on tiny prey. As filter-feeders, they take huge amounts of water into their mouths and strain out prey including shrimp-like krill and other zooplankton using baleen plates made of keratin, the same material found in fingernails.

During feeding dives, the whale exhibited extremely low heart rates, typically of four to eight beats per minute and as low as two. After surfacing to breathe following foraging dives, the whale had heart rates of 25 to 37 beats per minute.

(Reporting by Will Dunham; Editing by Sandra Maler)

Reuters

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First-Ever Measurement of a Blue Whale's Heartbeat Reveals Surprising Extremes - ScienceAlert

New Dean of Science at University of Waikato – Scoop.co.nz

Wednesday, 27 November 2019, 9:43 amPress Release: University of Waikato

27 November 2019

Leading Plant PhysiologistProfessor Margaret Barbour welcomed as Dean of Science atUniversity of Waikato

Professor Margaret Barbour commencedher position as Dean of Science at the University of Waikatoon 18 November. She was previously Professor of PlantPhysiology in the School of Life and Environmental Sciencesat the University of Sydney.

Vice-Chancellor, ProfessorNeil Quigley says, We are delighted to welcome ProfessorBarbour back to the University of Waikato where she startedher tertiary education. Professor Barbour is a leadingexpert in her scientific field, and will be an asset inleading the School of Science into the future.

Experimental plant physiology is the focus of ProfessorBarbours research, and she is an internationallyrecognised expert in stable isotope effects duringphotosynthesis, respiration and transpiration of higherplants. She pioneered novel stable isotope techniques tomeasure isofluxes between plants and the atmosphere, as wellas developing an underlying theory to explain variation.

These techniques and theory have allowed newunderstanding of plant regulation of carbon and waterdynamics, with applications in crop production, plantecological physiology and paleoclimatic reconstruction fromtree rings.

Professor Barbour completed her Bachelor andMaster of Science from the University of Waikato, beforeheading overseas to complete her PhD in plant physiologyfrom the Australian National University (ANU).

Followingher PhD, Professor Barbour spent time at Landcare Researchin New Zealand, before moving back over the Tasman to takeup an Australian Research Council Fellowship at theUniversity of Sydney, and then more recently as AssociateDean of Research for the Faculty of Science.

I amdelighted to be back in my personal heartland, and excitedto contribute to the future of the University of Waikato,says Professor Barbour.

In this age of publicquestioning of scientific evidence, it is important that wescientists find new ways to connect our understanding withthat from other disciplines, with policy makers, and withthe public. I look forward to helping build theseconnections.

ENDS

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Illuminating the Nobels | UDaily – UDaily

From the cells in our bodies and the cell phones in our pockets, to the structure of the entire universe, the research honored by this years Nobel Prizes covers a lot of ground.

But, as is always the case at the University of Delawares annual Nobel Symposium, faculty members were able to use their own expertise to share insights into the prize-winning work with an audience of UD and community members.

As a bonus, the audience at this years event also learned about two scandals involving the prize for literature.

The symposium on Tuesday, Nov. 19, hosted by the College of Arts and Sciences in Harker Lab, featured seven short talks about this years laureates and their work, as well as a special tribute to novelist Toni Morrison, who won the Nobel Prize in Literature in 1993 and died in August.

The following are the prizes highlighted at the symposium.

Physiology or Medicine

Just as a candle needs oxygen to burn cleanly, cells need oxygen, to convert food into energy, Ramona Neunuebel, assistant professor of biological sciences, said at the symposium. But too much oxygen is deadly, and too little is deadly.

Neunuebel explained the Nobel Prize in Physiology or Medicine, which was awarded to William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza for discovering how cells are able to sense and then adjust their oxygen levels. Oxygen levels can vary, depending on elevation or injury, for example, and scientists have long been puzzled by how cells are able to adapt.

The three laureates put the puzzle together by looking at different aspects of the molecular process that regulates the activity of genes. Together, they found the pathway, Neunuebel said.

She noted that, based on these discoveries, drugs are being developed to target anemia, kidney disease, cancer and other serious conditions.

Economics

Jim Berry, associate professor of economics, began his talk by pointing out that, despite billions of dollars spent each year on aid to developing countries, the question, Does this aid actually work? has been complex and difficult to answer.

But, he said, thanks to the work by this years winners of the Nobel Prize in economic sciences, a much more reliable, experimental approach has been developed. The laureates Abhijit Banerjee, Esther Duflo and Michael Kremer are all relatively young, and Duflo is only the second woman to win the economics prize, Berry said.

Their approach, which Berry termed, Start small, then go big, breaks down the factors involved in each aspect of aid. In seeking to improve education, for example, a researcher might start with the question of whether providing more textbooks to an impoverished school would make a difference in the students achievements and then randomly assign schools in the area being studied to receive or not receive more books.

(The answer? Using teaching methods that are responsive to students needs, not the quantity of textbooks, is what makes a real difference.)

This is an approach thats similar to a medical trial, Berry said. By doing more and larger randomized experiments of this type, researchers can much more accurately identify strategies that are effective, and donors can then target aid to those initiatives.

The research conducted by this years laureates has considerably improved our ability to fight global poverty, the Nobel Prize organization said in announcing the award.

Physics

Sarah Dodson-Robinson, associate professor of physics and astronomy, discussed this years Nobel Prize in Physics, awarded to three scientists, one whose work led to a new understanding of the universes history and two who discovered the first exoplanet orbiting a solar-type star.

This is all about looking for other worlds and understanding the universe, Dodson-Robinson told the audience.

James Peebles won his share of the prize for 50 years of work that is now the basis for our understanding of the universe, the Nobel organization said. His work moved cosmology [the study of the origin of the universe] from pencil and paper to science, Dodson-Robinson said.

The other recipients, Michel Mayor and Didier Queloz, made the first discovery of an exoplanet, a planet outside our Solar System, that is orbiting a solar-type star. They made the discovery in 1995, and since then, Dodson-Robinson said, Weve gone from one planet to thousands. Its been a real revolution in astronomy.

Peace

When Ethiopian Prime Minister Abiy Ahmed Ali was awarded the 2019 Nobel Peace Prize, the announcement also specifically recognized all the stakeholders working for peace and reconciliation in Ethiopia and in the East and Northeast African regions.

At UDs Nobel Symposium, Wunyabari Maloba, professor and department chair of Africana studies and professor of history, noted that the Peace Prize is intended to honor the recipient but also to encourage other leaders to undertake reforms.

Abiy took office in April 2018 and worked with Eritrean President Isaias Afwerki to resume peace talks between the two nations in their long-running border conflict. The two leaders worked out the principles of an agreement, warfare ended and the border between the two countries was reopened.

Although there have been setbacks since then, the prize should be seen as an encouragement for the reforms Abiy has implemented, Maloba said. Something to celebrate here is that half of his cabinet is composed of women, Maloba added.

The hope, he said, is that the Peace Prize will inspire other leaders to demonstrate the courage and daring to bring about peace and stability.

Chemistry

Lithium-ion batteries play a role in every part of our lives, including the battery thats in your pocket right now powering your mobile phone, said Eric Bloch, assistant professor of chemistry and biochemistry.

He explained this years Nobel Prize in Chemistry, which recognized the research conducted by John Goodenough, M. Stanley Whittingham and Akira Yoshino. The three worked separately on different aspects of building a better battery, with the result being the lightweight, rechargeable and powerful lithium-ion battery thats now used in phones, laptops and electric vehicles.

Calling the recognition overdue, Bloch said the battery will continue to play a key role in the future, especially as a means to store energy generated by wind and solar power.

If were going to transition away from fossil fuel lithium-ion batteries are how were going to do it, Bloch said. And we have these three [laureates] to thank.

Literature (2018 and 2019)

No prize was awarded last year in the literature category, after a sexual assault and financial scandal disrupted the Swedish Academys awards committee. The organization regrouped after several resignations and this year awarded two prizes.

Viet Dinh, assistant professor of English, discussed both writers who were honored Olga Tokarczuk, a Polish author who won the delayed 2018 prize, and Peter Handke of Austria, who was awarded the 2019 Nobel. The two authors, Dinh said, provide interesting counterpoints to each other, with different styles and bodies of work.

Not all of Tokarczuks books have been translated into English, and Dinh focused on those that have. He described her 2007 work, Flights, as a fascinating book composed of 116 vignettes. The extremely short stories, he said, mix fiction and fact, jump forward and back in time and can each stand alone, but together they form a constellation of themes focused on the concept of travel.

Dinh also spoke about Tokarczuks Drive Your Plow Over the Bones of the Dead, which he said has a narrower focus than the expansive Flights. The author takes a story that could be a classic whodunit mystery and transforms it into a kind of fable, he said.

While Tokarczuks body of work is smaller and has an outward focus, Handkes is much larger and more diverse, Dinh said. Hes written novels, essays, dramatic works and screenplays over more than 50 years, including The Goalkeepers Anxiety at the Penalty Kick, Offending the Audience and Wings of Desire.

The Nobel organization called him one of the most influential writers in Europe since World War II, but his controversial selection for this years prize has created another scandal. His 1996 book A Journey to the Rivers: Justice for Serbia, depicted Serbia as the victim of the 1990s Yugoslav conflict, and in 2006 he spoke at the funeral of Serbian nationalist leader Slobodan Milosevic, who died while on trial for war crimes.

The dilemma, Dinh said, is, How do you approach a work of art when the artist is known to hold [offensive or controversial] views? He suggested that, instead of ignoring the views or refusing to engage with the artists work, readers should consider also reading works by other writers that offer context and different points of view.

Special presentation honoring Toni Morrison

A. Timothy Spaulding, associate professor of English and of Africana studies, gave a tribute to 1993 laureate Toni Morrison, who is the only black woman to have won the Nobel Prize in Literature.

Calling her prose luminous and poetic, Spaulding said, It is impossible to read a Toni Morrison novel without deep feeling or contemplation.

He praised the vitality of Morrisons language and the way in which her work speaks so clearly and unflinchingly about the horrors of slavery and the legacy of racism. Even while writing about such topics, Spaulding said, Morrisons beautiful and eloquent use of language creates compelling contradictions and paradoxes.

Her work, he said, is intensely rooted in the black experience but also has a broad reach that speaks to all readers.

Morrison published her first novel, The Bluest Eye, in 1970, and went on to publish 10 other acclaimed works of fiction, including Sula, Song of Solomon and Beloved, which won the 1988 Pulitzer Prize.

This article includes information from the Nobel Prize organization.

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Illuminating the Nobels | UDaily - UDaily

Prestigious NY Cancer Center Will Spend $3.7M To Study Bogus Cancer Treatment – Forbes

Reportage in a Chinese medicine practice in Lyon, France Acupuncture session. (Photo by: ... [+] BSIP/Universal Images Group via Getty Images)

Sometimes I'm not sure whether the best response to pseudoscience is to ignore it, or to patiently try to explain why it's wrong, or to get mad.

This week I'm mad.

My anger and frustration was triggered bya tweetfrom Memorial Sloan-Kettering's Integrative Medicine account, shown here:

Image captured by the author

For those who don't know,Memorial Sloan-Kettering Cancer Centeris one of the world's leading cancer centers, both for treatment and research. If you are diagnosed with cancer, MSK is one of the best places to go.

But not everything at MSK is world class. Unfortunately, they have an"integrative medicine"center that offers a mixture of therapies ranging from helpful to benign to useless. One of their biggest activities is acupuncture, which they claim offers a wide range of benefits to cancer patients.

The MSK tweet shown here was boasting abouta new, $3.7 million studyfunded by NIH to study the effect of acupuncture on pain that cancer patients experience from chemotherapy and bone-marrow transplants.

Here's why I'm mad: cancer patients are extremely vulnerable, often suffering the most frightening and difficult experience of their lives. They are completely dependent on medical experts to help them. When a place like MSK suggests a treatment, patients take it very seriouslyas they should. But they really have no choice: a cancer patient cannot easily look for a second opinion, or switch hospitals or doctors. Even if they have the money (and cancer treatment is extremely expensive), switching hospitals might involve a long interruption with no treatment, during which they could die, and it might also involve traveling far from their home.

Offering these patients ineffective treatments based on pseudoscienceand make no mistake, that's what acupuncture isis immoral. Now, I strongly suspect that the MSK's "integrative medicine" doctors sincerely believe that acupuncture works. Their director, Jun Mao, is clearly a true believer, as explained inthis profile of himon the MSK website. But that doesn't make it okay.

I've written about acupuncture many times before (here,here,here, andhere, for example), but let me explain afresh why it is nonsense.

Acupuncture is based on a pre-scientific notion, invented long before humans understood physiology, chemistry, neurology, or even basic physics, which posits that a mysterious life force, called "qi," flows through the body on energy lines called meridians. As explainedin this article by MSK's Jun Mao:

"According to traditional Chinese medicine ... interruption or obstruction of qi was believed to make one vulnerable to illness. The insertion of needles at specific meridian acupoints was thought to regulate the flow of qi, thus producing therapeutic benefit."

Today we know that none of this exists. There is no qi, and there are no meridians. In that same article, Jun Mao continued by admitting that

"the ideas of qi and meridians are inconsistent with the modern understanding of human anatomy and physiology."

And yet this is what they offer to patients at MSK.

Just to be certain, I readone of the latest studies from MSK, published early this year, which claims to show that acupuncture relieves nausea, drowsiness, and lack of appetite in multiple myeloma patients who were going through stem cell transplants.

It's a mess: totally unconvincing, and a textbook case of p-hacking (ordata dredging). The paper describes a very small study, with just 60 patients total, in which they measured literally dozens of possible outcomes: overall symptom score at 3 different time points, a different score at 3 time points, each of 13 symptoms individually, and more. I counted 24 different p-values, most of them not even close to significant, but they fixated on the 3 that reached statistical significance. The two groups of 30 patients weren't properly balanced: the sham acupuncture group started out with more severe symptoms according to their own scoring metric, andFigure 2in the paper makes it pretty clear that there was no genuine difference in the effects of real versus sham acupuncture.

But they got it published (in a mediocre journal), so now they point to it as "proof" that acupuncture works for cancer patients. This study, bad as it is, appears to be the basis of the $3.7 million NIH grant that they're now going to use, they say, in "a larger study in 300 patients to confirm these previous findings."

And there you go: the goal of the new study,according to the scientists themselves, is not to see if the treatment works, but to confirm their pre-existing belief that acupuncture works. Or, asone scientist remarked on Twitter, "they already have a result in mind, the whole wording of this suggests that they EXPECT a positive outcome. How did this get funded exactly?"

Good question.

So I'm mad. I'm mad that NIH is spending millions of dollars on yet another study of a quack treatment (acupuncture) that should have been abandoned decades ago, but that persists because people make money off it. (And, as others have explained in detail, acupuncture is actually a huge scam that former Chinese dictator Mao Zedong foisted on his own people, because he couldn't afford to offer them real medicine. For a good expos of Chairman Mao's scam,see this 2013 Slate piece.)

But I'm even more upset that doctors at one of the world's leading cancer centers are telling desperately ill patients, who trust them with their lives, that sticking needles into their bodies at bogus "acupuncture points" will relieve the pain and nausea of chemotherapy, or help them with other symptoms of cancer. I'm willing to bet that most MSK doctors don't believe any of this, but they don't want to invest the time or energy to try to stop it.

(I am somewhat reassured by the fact that MSK'sTwitter accounthas nearly 75,000 followers, while it's integrative medicine Twitter account has just 110.)

Or perhaps they are "shruggies": doctors who don't believe in nonsense, but figure it's probably harmless so they don't really object. To them I suggest this:read Dr. Val Jones's accountof how she too was a shruggie, until she realized that pseudoscience causes real harm.

And finally, let me point tothis study inJAMA Oncologyfrom last year,by doctors from Yale, which looked at the use of so-called complementary therapies among cancer patients. They found that

"Patients who received complementary medicine were more likely to refuse other conventional cancer treatment, and had a higher risk of death than no complementary medicine."

And also seethis 2017 studyfrom the Journal of the National Cancer Institute, which found that patients who used alternative medicine were 2.5 times more likely to die than patients who stuck to modern medical treatments.

That's right,Memorial Sloan-Kettering: patients who use non-traditional therapies are twice as likely to die. Thats why Im mad. This is not okay.

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Prestigious NY Cancer Center Will Spend $3.7M To Study Bogus Cancer Treatment - Forbes

Breathe to Perform: Improve Your Breathing To Unlock Hidden Athletic Potential – BOXROX

If youre anything like me, the memory of your very first CrossFit WOD is burned into your lungs.

From the moment that the clock started running until the very last rep of the workout, you likely sucked wind harder than at any previous point in your life. As you fell to the ground afterwards in a heap of exhaustion, a love/hate relationship with the sport of fitness developed right on the chalk stained and sweat soaked spot.

What many of us were experiencing was an introduction to metabolic conditioning. This newly coined term describes a high intensity training model designed to, in the words of CrossFit founder Greg Glassman, increase the storage and delivery of energy for any activity.

In a 2003 Crossfit Journal article, Glassman shared his position on the importance of metabolic conditioning to avoid specificity of adaptation allowing for first wave cardiovascular and respiratory adaptations.

Its been 16 years since that original journal article was written.

16 years of thrusters, wall-balls and those ever elusive airdyne calories. 16 years of sweat, grit, commitment, and community. A lot of memories and training milestones can be packed into a 16 year time frame.

There are a lot of cardiovascular and respiratory adaptations that can be made as well. One of the greatest physiological adaptations that an athlete can make, however, remains largely untapped in the sports training community.This leaves the door to progress wide open, despite how seasoned and experienced a CrossFit athlete you may be. It is the adaptation that determines how the process of delivering energy for any activity that Glassman spoke about 16 years ago actually occurs.

Its our ability to utilise oxygen more efficiently and more effectively.

Understanding how oxygen is directly related to energy production may mark the next major paradigm shift in human health, fitness and sports performance.

When CrossFit first began, anaerobic output was a glaring weak link in the athletic chain for many athletes. The sport has evolved to the point where this statement might not be true anymore.

Past Games events have demonstrated the effectiveness of CrossFits ability to increase work capacity over short duration. High intensity workouts showcase a collective need to perform more aerobic capacity training.

But, what is aerobic capacity? Does it mean just putting in more LSD (long, slow distance) efforts or is it changing the way that our body utilises oxygen to fuel the release of ATP to power muscular activity.

It is possible to put in hours of focused endurance work each week while never making the critical adaptation which allows this process of more effective energy delivery to take place: that process is an increased tolerance to carbon dioxide and must be trained specifically in order to be improved.

Take the following test from the book The Oxygen Advantage by Patrick McKeown to determine whether your breathing is a buried weakness or a hidden strength.

Note: This is not a test of willpower or a test of how long you can hold your breath. Once you get the first urge to breathe stop the timer and you will have the information that you need to assess your C02 tolerance.

Was it 10 seconds? 20 seconds? 40 seconds or more?

If you were in a large room filled with athletes performing this test you would find that C02 scores would run the gamut from less than 10 seconds to more than 40 seconds.

What does your score mean, and how does it affect your athletic performance?

A score below 20 seconds indicates a comparatively high level of sensitivity to carbon dioxide which will require you to rely on a higher volume of oxygen during training while needing to offload more C02.

This is an athletic disadvantage when compared to an athlete who can work at higher intensities with an increased ability to utilise C02 for more efficient oxygen transport, instead of ridding the body of C02 prematurely and suffering the cost of gassing out as a result.

For every 5 second increase in your C02 tolerance score you can expect to feel more energy, increased stamina, and less fatigue in your aerobic training.

When you exhale and pinch your nose, carbon dioxide levels begin to rise. Your sensitivity to rising carbon dioxide will determine how you will need to breathe during a difficult workout which, in turn, determines your ability to use available oxygen to power those hard working muscles when you need it most.

I strongly believe that the ability to extract and utilisethese basic physiological principles will separate the pack in the seasons to come.

Although variance is a key tenet to the CrossFit training methodology, the WOD is written clearly on the board prior to each training session or competition along with the implicit energy system demands and estimated workout duration for all competitors to study.

A rudimentary understanding of energy consumption and energy demands allows each competitor to make basic decisions about pace prior to the workout beginning. Unlike a sport such as mixed martial arts where the energy demands may be directly dependant on the tactics and approach of your opponent, or a team sport such as basketball where a dynamic interplay between players dictates the pace of the game, CrossFit offers a strategic opportunity that is akin to understanding the basics of accounting.

Oxygen Is Currency. Movement is Expensive.

If you have a $1,000 budget for a 5 day vacation, you would be unlikely to spend $900 of it on the first day. Equally, if you saw a 21 minute workout on the whiteboard you would be unlikely to approach it as if it were a 400m sprint.

Understanding the aerobic and anaerobic demands of each workout beforehand allows you to approach each effort with a heightened level of athletic intelligence.

An understanding of how breathing impacts aerobic and anaerobic performance and that you can not only control your breathing but significantly improve it allows you to gain a competitive advantage in your next WOD despite the specific time demands of the workout.

Simple Breathing Techniques to Improve your Crossfit Performances

The process of cellular respiration is a complex one. Fortunately, even the most basic understanding of how oxygen fuels muscular activity can provide a distinct advantage in terms of pacing yourself during workouts as well as in the development of stronger breathing muscles and an increased tolerance to carbon dioxide: the secret ingredient when it comes to utilising oxygen effectively and efficiently.

The next time you find yourself bent over with hands-on-knees after a tough set of thrusters, struggling to get air into your lungs, keep the following in mind:

There is no shortage of available oxygen in the atmosphere.

It is your internal environment that has changed due to the intensity of the workout. More specifically, your ability to get oxygen from your bloodstream and into muscles has been diminished.

Thats because the key to unlocking oxygen from the bloodstream is C02 and big breaths taken while exhaling through your mouth are offloading C02 from the body at too high a rate to make efficient oxygen utilisation possible.

Heres an easy way to remember this next time that you train:

The amount of Co2 that you lose is the amount of oxygen that you cant use.

The knowledge of this basic physiological process becomes a competitive advantage for any athlete willing to train the following respiratory adaptations in order to master their breathing and improve their aerobic capacity:

You happen to have access to the most powerful and effective breathing machine ever created: the human nose.

The nose is designed for the purpose of up-taking oxygen, removing harmful particles from the atmosphere, warming air prior to entering the body and creating a highly pressurised flow of oxygen directly into the lungs and diaphragm. It also induces the release of nitric oxide, a potent vasodilator that widens the walls of your blood vessels creating a more effective pathway for oxygen rich blood to make it to muscles.

It may be smaller than the mouth, but thats the athletic advantage. If getting more oxygen into our bodies were the solution to avoid gassing out in workouts we would simply take bigger breaths. However, oxygen is in no short supply.

The ability to use available oxygen i.e, extract it from the hemoglobin in the bloodstream, which is the job of carbon dioxide, is the challenge that we face when training.

Nasal breathing allows us to increase our oxygen utilisation while decreasing the amount of C02 that we offload while training.

Keep in mind that C02 is not simply a waste gas, it is like oxygens teammate in a partner WOD. They work together and if one bales out, the others performance suffers.

Breathing through the nose can initially be difficult for many athletes. Therein lies the advantage for those willing to train the adaptation.

After a few weeks of consistent training, many athletes can perform at upwards of 90% max heart rate with nasal-only breathing. They uptake oxygen faster and more effectively and delay premature transitions into anaerobic respiration which come at the cost of increased metabolic waste to buffer.

They also remain fresh so that, if they do decide to shift to mouth breathing near the end of a workout in order to sprint to the finish, they are positioned for a powerful finish.

Use an assault bike, rower or ski erg and try the following 4 minute warm-up.

EMOM for 4 minutes:

Nasal breathing only. Put out as much wattage as the prescribed breathing cadence allows.

Before long you will be able to increase the wattage while sticking to the prescribed warm-up breathing pattern.

This is akin to doing pull-ups and push-ups for your breathing muscles while making the physiological adaptations to carbon dioxide that help separate you from the pack and break through those PR plateaus that weve all experienced.

Additional Training Tips

How you breathe post-workout will affect how quickly your heart rate returns to baseline levels as well as how effective your post-workout mobility session will be (you cant relax a body that is still in a high-stress state).

Your ability to recover more effectively sets you up for success in your next training session. This simple post-workout breathing exercise can help you optimise your recovery and get the most from your hard work:

As a CrossFit athlete, you train your body and you push it hard. Youve most likely already made nutritional changes to support your training and youve worked to prioritise sleep to support your recovery. Youve looked at the various pieces that make up the training puzzle and youve worked hard to put each one in place.

It just so happens that one of the most important puzzle pieces may have been right underneath our noses the whole time

Training comes down to getting oxygen to the body when it needs it most. No amount of willpower or dedication can outweigh the most basic and essential demands of our physiology. The more effective we become at using oxygen to fuel our athleticism, the higher we can raise the ceiling of our own performances potential.

David Bidler is a writer, speaker, and performance-breathing coach living in Portland, Maine. David owns The Distance Project: Strength and Conditioning. Follow him @the_distance_project on Instagram.

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Breathe to Perform: Improve Your Breathing To Unlock Hidden Athletic Potential - BOXROX

Biochemistry Analyzers Market Projected to Have a Stable Growth for the Next Few Years – The Denton Chronicle

Biochemistry analyzers are machines designed for analyzing blood, cerebral spinal fluid, urine, and other biological samples. These machines are equipped with electrochemical and optical technologies for measuring characteristics of the sample. Most of these analyzers use optical technologies for performing the measurements such as colorimetric, spectrometric, absorption, and fluoroscopic detection methods. These machines can also measure chemicals such as antigens, proteins, and molecules in body fluids. These analyzers offer several benefits such as fast measurement ability, accuracy, and high sensitivity when detecting even minuscule amount of chemicals.

On the basis of modality, the biochemistry analyzers market has been divided into bench top, and floor standing. Bench top analyzers are comparatively small in size and can be used with significant level of flexibility. In addition, in small laboratory settings, benchtop analyzes are preferred over space consuming floor standing analyzers. Considering the convenience benefits offered, growth rate of demand for bench top analyzers is expected to surpass the demand for floor standing analyzers during the forecast period.

On the basis of both value and volume, North America dominated the market in 2017. High penetration of these analyzers in countries such as U.S. and Canada are attributed to its strong base of pharmaceutical and healthcare sector. From supply side, many of the producers of biochemistry analyzers are located in this region and they have strong distribution channel penetration across hospitals, diagnostics centers, pharmaceutical and biotechnology companies, and academic research institutes.

Growth of the biochemistry analyzers market is hindered by factors such as its complex system integration is complex and high upfront cost. High upfront cost has dented its attractiveness among price sensitive customers in countries from Asia-Pacific.

Some of the major players operating in the global biochemistry analyzers market are Abbott, Siemens AG, Thermo Fisher Scientific, HORIBA, Ltd., F. Hoffmann-La Roche Ltd, Beckman Coulter Inc., Hologic, Inc., Danaher Corporation, Meril Life Sciences Pvt. Ltd., and Randox Laboratories Ltd.

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Biochemistry Analyzers Market Projected to Have a Stable Growth for the Next Few Years - The Denton Chronicle

Global Bench-top Veterinary Biochemistry Analyzers Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 – Breakaway Trends

The Bench-top Veterinary Biochemistry Analyzers Market report gives a purposeful depiction of the area by the practice for research, amalgamation, and review of data taken from various sources. The market analysts have displayed the different sidelines of the area with a point on recognizing the top players (Abaxis Europe, AMS Alliance, Biochemical Systems International, BPC BioSed, Carolina Liquid Chemistries Corp, Crony Instruments, DiaSys Diagnostic Systems GmbH, Gesan Production, Heska, Idexx Laboratories, LITEON IT Corporation, Medicalsystem Biotechnology Co., Ltd, Paramedical srl, Randox Laboratories, Scil Animal Care, URIT Medical Electronic) of the industry. The Bench-top Veterinary Biochemistry Analyzers market report correspondingly joins a predefined business market from a SWOT investigation of the real players. Thus, the data summarized out is, no matter how you look at it is, reliable and the result of expansive research.

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Global Bench-top Veterinary Biochemistry Analyzers Market report provides a valuable source of insightful data for business strategists. It provides the industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data (as applicable). The research analysts provide an elaborate description of the value chain and its distributor analysis. The report also looks at the influential factors that are affecting the development of the Global Automotive Bumpers Market. This statistical report also offers various internal and external driving as well as restraining factors for this research report.

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The scope of the report extends from market eventualities to a comparative rating between major players, price, and profit of the required market regions. This makes available the holistic view on competitive analysis of the market. Some of the top players involved in the market are profiled completely in a systematic manner.

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Global Bench-top Veterinary Biochemistry Analyzers Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 - Breakaway Trends

Global Biochemistry Analyzer Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 – PR Industry News

A profound analysis of the industry based on the "Biochemistry Analyzer Market" all over the world is named as Global Biochemistry Analyzer Market Report. The research report assesses the current as well as the upcoming performance of the Biochemistry Analyzer market, in addition to with newest trends in the market. The major player of the Biochemistry Analyzer market (URIT Medical Electronic, ELITechGroup, EKF Diagnostics, Spinreact, Mindray, Danaher, Roche Diagnostics)are also included in the market report. The report forecasts the future of the Biochemistry Analyzer market on the basis of this evaluation.

The research analysis for Biochemistry Analyzer market comprises each and every feature of the market all over the world, which starts from the Biochemistry Analyzer market description and ends on the Biochemistry Analyzer market segmentation (Semi-Automatic Biochemical Analyzers, Fully Automated Biochemistry Analyzers). In addition to this, each section of the Biochemistry Analyzer market is categorized and evaluated on the basis of goods, the end-user clients of the Biochemistry Analyzer market, and the employment of the products. The geographical categorization of the Biochemistry Analyzer market (Academic Research Institutes, Biotechnology Companies, Contract Research Organizations, Diagnostic Centres, Hospitals, Pharmaceutical Companies, Others) has also been evaluated thoroughly in the report.

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Global Biochemistry Analyzer Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 - PR Industry News