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Harvard Scientist Thinks It’s ‘Ludicrous’ to Compare His Genetics-Based Dating App to Eugenics – Daily Beast

A famed Harvard geneticist is defending his work on a genetics-based dating appand distancing himself from Jeffrey Epstein, the science-obsessed pedophile who fantasized about spreading his DNA by inseminating 20 women at a time at his ranch.

The fact that there are people with completely idiotic ideas about genetics doesnt mean Im one of them, George Church told The Daily Beast in a phone interview.

Just because they hung out with me briefly doesnt mean I bought into their malarkey in any sense, just like geneticists today dont buy into the eugenics of the 1920s.

Church has had to account for his links to Epstein numerous times since the disgraced money manager was indicted for sex-trafficking and then killed himself in jail last August. Most recently, he was grilled about their relationship during a 60 Minutes profile that included Churchs plans for the dating app, which critics have denounced as a modern form of eugenics.

Epstein helped fund Churchs lab at Harvard before being unmasked as a predatorbut Church has admitted maintaining contact with Epstein even after the financier served time and registered as a sex offender.

Now Church has confirmed to The Daily Beast that he was one of several notable scientistsincluding Harvard biology professor Martin Nowak, Harvard astronomy professor Dimitar Sasselov, MIT physics professor Seth Lloyd, and the pioneering biologist Steven Bennerwho attended a 2007 gathering on Epsteins private island Little St. James.

Photos verified by Church show them together on the beach and around a blackboard in discussion with Epstein. The property was nicknamed pedophile island by locals because of the alleged sexual abuse of girls, but Church said he saw nothing untoward at the gathering, which predated Epsteins 2008 guilty plea.

Scientific meetings take place all over the place, and usually youre so wrapped up in the meeting that you dont take advantage of the place youre in. This was one of those cases. We did our science nerd thing and left, he said, noting that the scientists slept on a different island.

Church said the attendees were there to discuss the origins of life and that Nowak later published a paper based on the discussions. We just came there for the meeting and then came back. We looked around the beach a bit. There wasnt much there, frankly. He was building something, some structure, he said.

Church said that Epstein had no influence on his work, which has been focused on allowing humans to live longer with fewer diseases.

To that end, he made an off-handed reference during the 60 Minutes interview to a dating app that would match couples with the goal of eliminating severe hereditary diseases. His brainchild was not well-received. A Fordham associate ethics professor told The Daily Beast the concept sounds like eugenics, likening it to the Nazi ideal of cultivating a master race.

Church said hes been describing the same idea for years now without any furor.

If you know what youre doing is the right thing to help families have healthy children, I dont think you need to worry whether somebody somewhere has been associated with you in a way thats less than ideal.

Church said it was preposterous to compare his work to eugenics.

Its ludicrous to think thats what Im doing, but it makes good clickbait, doesnt it? he said.

The app would prevent people from matching with partners with similar genetic mutations that would induce a congenital disease like Tay-Sachs on the couples children. The geneticist said the technology will likely work alongside established dating sites and apps as a premium service rather than as a standalone, and it wouldnt have access to a users full genome, only whether the person carries specific alleles related to congenital disease.

Eugenics is coercive. Rather than restricting peoples options for their health and their families, were expanding them, he said. Were not going to be forcibly sterilizing people, if thats the business model they think were up to. Thats as far from what we intend to do as can be.

The MIT Technology Review identified the technologys parent company as DigiD8, incorporated in September by Churchs cofounder Barghavi Govindarajan. Its slogan: Science is your wingman. Church said hes funding the app alongside private investors and declined to disclose the amount the fledgling company has raised, calling it adequate. Harvard is not among the investors, he said.

He sees the matchmaking app as a continuation of his work on genetics and part of his duty as a scientist.

I felt like Im providing all these great tools, but theyre very expensive. Gene therapy is a couple million bucks. I feel like its my responsibility to point out alternatives, he said. Its very early stage, though.

One of the questions lingering over the proposed technology is who will decide what genes the software will screen for. Would it further stigma against the chronically ill and disabled? Against trans people, as Vice suggested? Against certain races?

Church said he and his team would leave that question to clinical geneticists, but he described the criteria as genes that result in illnesses that cause very premature deaths, often with pain and a lot of medical costs. He said that the screening would likely rule out only five percent of someones dating pool.

There is no line, just as theres no line with what speed limits should be on the road, but you have to draw one, and medical doctors are very good at drawing practical lines, he said.

Church said hes open to critics, despite what he saw as their overreaction.

If any doubters, after they see whats actually there, make a compelling counterargument, I may change directions, he told The Daily Beast. Im very open to suggestions, and Im very interested to hear what everybody has to say once they see whats really there.

He said he wasnt expecting 60 Minutes to air his comments about the dating app. He published a FAQ Wednesday on his website explaining some details of what the technology would look like.

There are medical tests that perform the same function Churchs dating app would. Couples considering IVF can take genetic compatibility tests for specific conditions, and women undergoing the treatment can screen their embryos and weigh the option of abortion if they test positive. Churchs app would start far earlier in the romantic process, which he views as a positive.

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Harvard Scientist Thinks It's 'Ludicrous' to Compare His Genetics-Based Dating App to Eugenics - Daily Beast

Harvard scientist develops DNA-based dating app to reduce genetic disease that critics call eugenics – The Boston Globe

His idea: to include serious genetic disease as part of the criteria on a dating app by asking users to submit their DNA for whole genome sequencing.

Sound weird?

Plenty thought so after Church, in an interview with CBSs 60 Minutes on Sunday, revealed that he is developing the genetic matchmaking tool that could be embedded in any existing dating app. The point of the DNA tool, he says, is to prevent two carriers of the same gene for a rare genetic disease from even meeting in the first place, by making sure they cant view each others dating profiles. That way, on the off chance two people meet on the app, fall in love, and have children, theyll know the baby wouldnt be at risk of having a hereditary disease.

Church calls it digiD8. And so far, it has freaked out a lot of people.

The word eugenics screamed across headlines this week. Vice called it a horrifying thing that shouldnt exist. Gizmodo said it was a dating app that only a eugenicist could love. And some advocates worried Church was trying to wipe out genetic diversity and people with disabilities altogether. Ever considered that having a disease doesnt mean a life thats tragic or full of suffering? Alice Wong, the founder of the Disability Visibility Project, wrote on Twitter.

So in an interview with The Washington Post this week, Church tried to clarify what hes planning to do and how a dating app encoded with your DNA would work. He stressed his strong opposition to eugenics while insisting his lab values genetic diversity, saying the app would only address a subset of the most severe genetic diseases, such as Tay-Sachs or cystic fibrosis.

There are a lot of diseases which are not so serious which may be beneficial to society inproviding, for example, brain diversity. We wouldnt want to lose that, Church said. But if [a baby] has some very serious genetic disease that causes a lot of pain and suffering, costs millions of dollars to treat and they still die young, thats what were trying to deal with.

Church is heading the dating app project with digiD8s cofounder and CEO, Barghavi Govindarajan, as a self-funded startup with some investors he declined to name, as the MIT Technology Review first reported after the CBS interview. Under Churchs bio on the startups website, theres just a quotation: That is not an outlandish idea.

Hes been known to make that case for a lot of his provocative ideas the timelines of which are not always clear. Church who apologized this year for accepting about $500,000 from multimillionaire sex offender Jeffrey Epstein between 2005 and 2007 has been saying throughout the past decade that a woolly mammoth could be brought back from extinction, or he could reverse the aging process in humans. Both of those projects are still underway at the lab, the latter of which is being tried on dogs, he and Harvard students told CBS.

By contrast, he said all the technology is already available for the dating-app tool. Now its just a matter of finding a matchmaking service that actually wants to do this.

Pushing back on the eugenics comparisons, Church said the foundation of his idea is in genetic counseling, which offers couples preconception or prenatal genetic testing to check whether their baby could be at risk of inheriting a disease.

Embedding that into an app would work like this, he said: First, you would submit a sample of your spit to a lab for whole genome sequencing. Church gave inconsistent numbers of genetic diseases that the test would screen for, at first saying 120 to 3,000 but then settling closer to 120. The results of the test would be encrypted and confidential, and not even you, the user, would get to know your results or the results of others, Church said. The rest would work just like normal online dating you just wouldnt see a small fraction of dating profiles.

About 5percent of children are born with a severe genetic disease, and so that means youre compatible with about 95percent of people, Church said. Were just adding this [tool] to all the other dating criteria.

Several bioethicists The Washington Post spoke with said they would hesitate to compare Churchs project to eugenics, which included state-sponsored forced sterilization, mass killings, or imposed breeding throughout the late 19th century to the 1970s. Eugenics is a strong word, said Barbara Koenig, director of the University of California at San Franciscos Bioethics Program.

Rather, both Koenig and Mildred Cho, a professor at Stanford Universitys Center for Biomedical Ethics, said digiD8 reminded them of the digital version of Dor Yeshorim, an Orthodox Jewish organization based in New York that beat Church to the idea by a few decades. Church has cited the group as an inspiration.

The nonprofit was founded in 1983 as a response to higher rates of Tay-Sachs a fatal genetic disorder that destroys the nervous system that was devastating certain communities, such as Ashkenazic and Sephardic Jews. Before marrying, couples can go to Dor Yeshorim for genetic testing. To avoid stigmatizing people, the organization does not tell couples anything about their genes, just whether they are compatible. This is especially important in societies where theres less reliance on termination [of a pregnancy], Koenig said.

In its earlier days, the group faced virtually all the same questions and uncertainties from critics that digiD8 is encountering now. Even a decade after Dor Yeshorim was founded, The New York Times asked in a 1993 headline: Nightmare or the Dream of a New Era in Genetics?

Cho said she could understand why people reacted so negatively to Churchs idea, fearing a slippery slope or unintended consequences to the genetic technology. For now its a dating app, but how else might others harness genetic technology in a way that could further invade lives? To Churchs critics, digid8 is already over that line.

I dont think those fears are completely unfounded, Cho said. I think what people are reacting to is this sense of kind of genetic determinism, and this idea that somebodys DNA can somehow make them incompatible, as if all their other personality traits and behavior really isnt as important as their DNA.

But for Koenig and Cho, the other big question, aside from whether this will work, is whether people would even care to use it. Do people even want this in their dating app? Thats a question Church said hes trying to figure out as well.

An app seems silly to me, Koenig said. People dont fall in love and marry and have children based on purely hyper-rational decisions.

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Harvard scientist develops DNA-based dating app to reduce genetic disease that critics call eugenics - The Boston Globe

This genetic variant is underdiagnosed, under-recognized, and deadly | Penn Today – Penn: Office of University Communications

A genetic variant in the gene transthyretin (TTR)which is found in about 3 percent of individuals of African ancestryis a more significant cause of heart failure than previously believed, according to a multi-institution study led by researchers atPenn Medicine. The study also revealed that a disease caused by this genetic variant, called hereditary transthyretin amyloid cardiomyopathy (hATTR-CM), is significantly under-recognized and underdiagnosed.

The findings, which were published inJAMA, are particularly important given the U.S. Food and Drug Administrations approvalof the first therapy (tafamidis) for ATTR-CM in May 2019. Prior to the new therapy, treatment was largely limited to supportive care for heart failure symptoms and, in rare cases, heart transplant.

Our findings suggest that hATTR-CM is a more common cause of heart failure than its perceived to be, and that physicians are not sufficiently considering the diagnosis in certain patients who present with heart failure, says the studys corresponding authorDaniel J. Rader, chair of the Department of Genetics at Penn Medicine. With the recent advances in treatment, its critical to identify patients at risk for the disease and, when appropriate, perform the necessary testing to produce an earlier diagnosis and make the effective therapy available.

Read more at Penn Medicine News.

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This genetic variant is underdiagnosed, under-recognized, and deadly | Penn Today - Penn: Office of University Communications

Harvard Geneticist Making Genetics-Based Dating App Thinks It’s Ridiculous That We’re Comparing It to Eugenics – Jezebel

Photo: Craig Barritt (Getty Images for The New Yorker)

Harvard geneticist George Church thinks its ludicrous to compare his dating app that uses genes to pair adults together to eugenics. Its ludicrous to think thats what Im doing, but it makes good clickbait, doesnt it? Church told The Daily Beast.

Churchs dating app would stop people from matching with potential partners with similar genetic mutations that could result in conditions like Tay-Sachs, according to The Daily Beast. It would be a premium service on already existing dating apps. Eugenics is coercive. Rather than restricting peoples options for their health and their families, were expanding them. Were not going to be forcibly sterilizing people, if thats the business model they think were up to, Church said. Thats as far from what we intend to do as can be.

Hes painting the idea as a way to help people create families. If you know what youre doing is the right thing to help families have healthy children, I dont think you need to worry whether somebody somewhere has been associated with you in a way thats less than ideal, Church told The Daily Beast.

Curious about person associated with it whos less than ideal? Church used the interview to distance his connection to the late Jeffrey Epstein, who at one point proposed inseminating hundreds of women on his New Mexico farm. Just because they hung out with me briefly doesnt mean I bought into their malarkey in any sense, just like geneticists today dont buy into the eugenics of the 1920s, Church told The Daily Beast.

Epstein was one of the funders of Churchs lab at Harvard, and Church maintained contact with the convicted sex offender after Epstein registered as sex offender. In fact, Church went to Epsteins private island, Little St. James, in 2007. But dont worry, the scientists in attendanceslept on a separate island. Scientific meetings take place all over the place, and usually youre so wrapped up in the meeting that you dont take advantage of the place youre in. This was one of those cases. We did our science nerd thing and left, Church said.

Church said doctors will be the people drawing the line about what is acceptable to weed out of offspring, likely genes that produce illnesses that cause very premature deaths, often with pain and a lot of medical costs, he said. There is no line, just as theres no line with what speed limits should be on the road, but you have to draw one, and medical doctors are very good at drawing practical lines.

The only good part of this interview is his assertion that hes open to suggestions! If any doubters, after they see whats actually there, make a compelling counterargument, I may change directions, Church told The Daily Beast. Im very open to suggestions, and Im very interested to hear what everybody has to say once they see whats really there.

My compelling counterargument: Being casual about eugenics has never ended well.

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Harvard Geneticist Making Genetics-Based Dating App Thinks It's Ridiculous That We're Comparing It to Eugenics - Jezebel

Tipperary’s Dovea Genetics and Herdwatch join forces to launch new initiative – TipperaryLive.ie

Software company Herdwatch and AI company Dovea Genetics, two leading Irish companies in the Agri-sector, both headquartered in Tipperary with international operations, have entered a strategic partnership which will see the Herdwatch farm management software solution adopted by potentially thousands of Dovea Genetics customers.

Dovea Genetics was founded in 1952 and has been a leader in bovine artificial insemination (AI) since, while Herdwatch is part of FRS Network (Farm Relief Services), a farmer-owned co-operative established in 1980.

Herdwatch is used on over 11,000 farms in Ireland and the UK, making it the leading farm management software platform in those markets, while Dovea exports to 26 countries.

The two companies hope to bring even more efficiency gains to farmers who need every bit of help they can get in the current climate.

We are very pleased to team up with Herdwatch, as we share a common ethos and are both passionate about supporting our customers in making the best decisions for their farm business, said Dovea general manager Dr Ger Ryan.

He said that the Herdwatch solution had a full breeding life cycle module, integrated with ICBF, where farmers can track and manage serves, scans and get automatic reminders on due dates through-out their season which are all very important for our farmers.

Herdwatch has made a name for itself over the past six years by helping farmers save hours on paperwork every week, and make better decisions via an easy-to-use app on mobile, tablet or laptop.

The Roscrea-based software company is set to deliver even more innovation as it launches a completely new version of their software this week.

This new app, called Herdwatch NG (Next Generation) is leaner, meaner and faster than ever, according to the company.

FRS are very excited to be associated with the Herdwatch success story in Tipperary and right across the country, said Peter Byrne, FRS Network CEO and Herdwatch director.

This Next Generation app had taken significant investment and as a farmer-owned co-op FRS was delighted it will make such a difference for farmers, he said.

The new app is being launched at the Winter Fair in Belfast by rugby legend Rory Best, who uses Herdwatch on his suckler farm in County Down.

The Next Generation Herdwatch app will be a great benefit to me as I transition from professional rugby back to looking after our herd at home along with a few other projects. Like in Rugby, you have to make things which are complicated appear simple, and Herdwatch, which was already easy to use, will be faster and easier than ever before, said Rory.

The Herdwatch Next Generation app is available to download for free on the Apple App Store and Android Play Store. A free plan is available for all farmers, with yearly PRO memberships starting at 79, plus VAT.

For more information about Herdwatch, visit http://www.herdwatch.com or call 0505-34400.

For more information about Dovea Genetics, visit http://www.doveagenetics.ie or call 0504-21755.

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Tipperary's Dovea Genetics and Herdwatch join forces to launch new initiative - TipperaryLive.ie

Sanofi Says Its $2.5 Billion Biotech Takeover Is Just the Beginning – The Motley Fool

As the year comes to a close, Sanofi (NASDAQ:SNY) has a holiday gift for investors in the form of a new strategy. The French drugmaker announced a $2.5 billion biotech takeover in the growing immuno-oncology field earlier this week, then a day later said it is dropping research in the diabetes and cardiovascular fields. This is big news because Sanofi's top-selling drug is diabetes drug Lantus. The problem is that with pricing pressure from competitors, Lantus' sales have been sliding -- and fast.

IMAGE SOURCE: GETTY IMAGES.

Lantus brought in more than $1.2 billion in the third quarter of 2017, and by the same period last year, the figure dropped to less than $1 billion. Sanofi reported a 17.5% decline in Lantus sales to $837 million in the third quarter of this year. To make matters worse, the rest of the diabetes and cardiovascular business has followed, weighing down earnings, while areas including oncology and immunology grew.

That's why the stock market applauded new Chief Executive Officer Paul Hudson's plan to refocus the business. Sanofi shares gained 6.2% on Tuesday after Hudson's comments.

Hudson, in his quest to focus on products and areas that are growing, targets $11 billion in sales for eczema treatment Dupixent. Sales of the drug soared 142% in the third quarter to reach $635 million. The company also will prioritize the development of six innovative investigational products in the areas of hemophilia, lysosomal storage disorders, respiratory syncytial virus, breast cancer, and multiple sclerosis.

Halting research in diabetes and cardiovascular, along with other efforts, is meant to help Sanofi reach $2.2 billion in savings by 2022. In other financial news, the company plans on expanding its business operating income margin to 30% by that year and to 32% by 2025. Business operating income is a non-GAAP measure of financial performance in which Sanofi eliminates elements such as acquisition-related effects and adds items like share of profits or losses from certain investments. The company also aims to increase annual free cash flow 50% by 2022.

Sanofi is reorganizing its operations into three business units: specialty care, vaccines, and general medicine. Consumer healthcare, which includes products like over-the-counter painkillers, will be a stand-alone business with its own R&D and manufacturing processes. Reutersreported that Sanofi might sell the unit or look for a joint venture. Consumer healthcare generated $5.2 billion in sales for Sanofi in 2018, a 3% increase from the previous year. That was about half of the figure generated by the specialty care unit, which grew 29% year over year.

Sanofi said cash from its businesses will be spent on further investment internally, acquisitions, and -- good news here, investors -- increasing the annual dividend. The last payment, in May, was $3.42, increasing for the 25th straight year.

Considering all of the good news, Sanofi isn't looking expensive. According to Zacks research, it trades at 14.16 times earnings, slightly cheaper than the large-cap pharmaceutical industry average of 14.85. The stock has gained 17% so far this year to about $49, but Wall Street predicts at least a bit more upside, with the average analyst price target at $52. Investors should also bear in mind that analysts might adjust their estimates and outlooks in the wake of Hudson's presentation.

With total net sales down 1.1% in the third quarter and the former big businesses of diabetes and cardiovascular slowing, Sanofi didn't present the best investment case a few weeks ago. This week's news, however, changed the landscape. The company is acquiring immuno-oncology company Synthorx (NASDAQ:THOR) to boost a part of its own business that is growing. It is halting the spending on struggling units and reallocating resources to stronger ones. And it continues to think of investors with the goal of boosting dividends.

For those looking to add to pharmaceutical holdings, Sanofi looks like a promising candidate going into 2020 and beyond.

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Sanofi Says Its $2.5 Billion Biotech Takeover Is Just the Beginning - The Motley Fool

Why is it that boy scouts will, but girl scouts try? Change the Promise, please. | Opinion – NJ.com

By Debbie Haine Vijayvergiya

Words matter just ask Girl Scout Troop 20923.

The troop, comprised of sixth-graders from Maplewood and South Orange, has spent the past year cultivating a grass-roots advocacy effort, #IWILL.

They are asking that Girl Scouts of the USA (GSUSA) modify the Girl Scout Promise and Law to be more empowering for girls everywhere.

#IWILL was born out of a Womens Leadership conference troop co-leader Jaime Barnes attended where she heard Dr. Cindy Wahler, psychologist and expert in human behavior, speak about female communication style.

Dr. Wahler shared that women, juxtaposed to men, often resist self-promotion and use communication tags, or indirect language, when offering insights or contributions to discussions. By doing this, women inadvertently and often unconsciously diminish the strength of their message and their brand.

She went on to use the Girl Scout Promise and Law vs the Boy Scout Oath and Law as an example of how ingrained this is in our language and our culture.

The Boy Scout Oath states, I will and the Girl Scout Promise says, I will try; The Boy Scout Law states, A Scout is and the Girl Scout Law says, I will do my best to be.

Her talk was eye opening for Ms. Barnes, her co-leader, Catherine DOrazio, and their troop. Before coming to any conclusions, the troop did their own research to understand what Dr. Wahler was referring to.

They began by observing the behaviors of their classmates, both girls and boys. The results were astounding. They noticed that boys were quicker to answer questions and stated their responses with confidence. In contrast, girls in their classrooms tended to hang back, hesitate when called on, and had a hard time expressing their thoughts in a concise manner.

The troop also researched women in leadership positions across business, entertainment and politics and were dismayed to learn that women still hold a minority of these important roles across all sectors of our society.

In the end, Troop 20923 recognized Dr. Wahlers point and unanimously agreed that things had to change! Originally, the troop leaders were only going to modify the promise and law for their troop. But the Troop felt a sense of responsibility to the Girl Scout community and decided to raise awareness for all Girl Scouts.

Troop 20923 observing the behaviors of their classmates, noticing that boys were quicker to answer questions and stated their responses with confidence. In contrast, girls tended to hesitate when called on, and had a hard time expressing their thoughts in a concise manner.

Their request is simple - that GSUSA revise the Girl Scout Law and Promise by eliminating the words try and do my best to be more inspiring and confidence-instilling. Even though the edits are minor, Troop 20923 is confident that the impact on the Girl Scout community will be major.

As the troop leaders explained, 'try is just three letters, but it has serious implications to how girls value themselves and what we, as a society, expect of them. An organization with a mission to develop "girls of courage, confidence, and character should not continue using language that inadvertently and potentially unconsciously, diminishes girls strength and confidence.

When Juliette Gordon Low founded GSUSA in 1912, she envisioned an organization to prepare girls to meet their world with courage, confidence, and character." Girls Scouts is one of the most prominent leadership development organizations for girls today. With over 2 million members, GSUSA has an obligation to shape this next generation of girls and women so that they can have the success and achievement they desire and deserve.

No, more than ever, its important that we send the right messages to girls, so that our future leaders have the confidence to express themselves with authority and assurance.

Speaking for myself, I sincerely hope that Troop 20923 gets the opportunity to be heard. Theyve written letters to GSUSA and submitted a formal request through Girl Scouts Heart of New Jersey for inclusion in the G.I.R.L. 2020 Convention. A change like this can only be achieved through a vote at the tri-annual convention. They are now working on getting the word out and building support for #IWILL. The troop is doing their part, so please do yours.

Dr. Cindy Wahler said it best, These girls are our role models for both our current and future generations! They have courage and are bold. Please show them having a voice matters. Empower them to make a difference by signing their petition.

Debbie Haine Vijayvergiya is a stillbirth parent advocate. She lives in Maplewood with her husband and two kids.

The Star-Ledger/NJ.com encourages submissions of opinion. Bookmark NJ.com/Opinion. Follow us on Twitter @NJ_Opinion and on Facebook at NJ.com Opinion. Get the latest news updates right in your inbox. Subscribe to NJ.coms newsletters.

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Why is it that boy scouts will, but girl scouts try? Change the Promise, please. | Opinion - NJ.com

Communication Issues to Solve? Try This – Thrive Global

Communication issues are at the top of the list of challenges 21st-Century leaders are facing. Leaders who learn to communicate best win. Lets dig into a simple approach that may help you successfully navigate one communication issue internal conflict.

I sat down with a Millennial leader yesterday to discuss how to deal with conflict in his organization. The issues he face are not unique. Leaders across the country are dealing with conflict either with or between their employees. We ended up discussing a theory that could be very valuable tool for leaders.

In the 1960s, psychiatrist Eric Berne developed the theory ofTransactional Analysisto explain human behavior. The real value I see in this theory is that it is easily understandable for most anyone. A person does not have to be a psychiatrist or some sort of genius to understand the basics. Once a person understands this theory, its easy to see the root issue and the starting point for solving communication issues. Lets dig in!

In order for managers and supervisors to be successful in todays multi-generation workforce, they must take a very individualistic approach to leading employees. The Transactional Analysis theory is a great tool to help leaders do that.

The foundation of the theory is based on what Berne callsego state. Putting this into my own words as I understand it, Id say the ego state is where a personshead is atin the moment when it comes to the situation.

For leaders, understanding that people approach situations with different perspectives and thought processes is key to correctly breaking down the conflict and moving forward in a positive direction. Bernes theory states that there are 3 ego states: Parent, Child and Adult. Everyone can experience each state. Lets dig into what you need to know.

The theory explains the Parent ego state is created with the experiences a person has in the first five years of life. During this time, kids are hearing lots of Do this and Dont do this statements.

In the workplace, employees in the Parent ego state will likely be the ones telling others what to do or how it is most of the time. You might say they have a my way or the highway approach.

The Child ego state is different than the Parent ego state in that the Parents mindset is around control, where as the Child ego state is more focused around feelings. The theory says that this ego state, just like the Parent ego state, is created with the experiences a person has in the first five years of their life. However, instead of processing commands from authority figures as Do this or that, the Child ego state processes things less on what is being said to them and more how it made them feel.

In the workplace, employees acting in the Child ego state may be operating more on feelings than facts.

The theory says that the Adult ego state starts becoming present as early as one year old. In really simple terms, the Adult ego state allows a person to be able to see things as they really are, not just as they have been told or felt. Those operating in the Adult ego state are able to separate feelings from fact.

In the workplace, your goal as a leader should be to get your people to consistently operate from the Adult ego state. Through the Adult ego state, people are able to make sound decisions for themselves and for the business.

It does a leader no good to learn something new and never put it into practice. So, with the Transactional Analysis theory weve just discussed, take action! Start simply solving communication issues among your team today.

Figure out your own current ego state. Next, take the time to figure out the ego state of your people. Then, educate and empower your people with this theory.

My favorite thing about this theory is that most every employee no matter their level of education or sophistication can understand the foundational difference between the words Parent, Adult, and Child. Once briefly explained, its very clear that everyones goal should be to approach everything as an adult.

If you are dealing with conflict, explaining this theory to everyone involved may help them correctly identify their current ego state and potentially shift their approach accordingly. This may help you as a leader open your employees eyes to root communication issues. When everyone has a clear understanding of the problem, you can work moire successfully towards a solution.

Ultimately, we are all adults working together but we dont always act and think like it. Its your responsibility as a leader to get people to where they need to be. My hope is that when you are working to solve communication issues, this theory will be a valuable tool in your pocket to help you do just that!

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Communication Issues to Solve? Try This - Thrive Global

HKU scientists develop a deep learning approach to predict disease-associated mutations of the metal-binding sites – India Education Diary

During the past years, artificial intelligence (AI) the capability of a machine to mimic human behavior has become a key player in high-techs like drug development projects. AI tools help scientists to uncover the secret behind the big biological data using optimized computational algorithms. AI methods such as deep neural network improves decision making in biological and chemical applications i.e., prediction of disease-associated proteins, discovery of novel biomarkers and de novo design of small molecule drug leads. These state-of-the-art approaches help scientists to develop a potential drug more efficiently and economically.

A research team led by Professor Hongzhe Sun from the Department of Chemistry at the University of Hong Kong (HKU), in collaboration with Professor Junwen Wang from Mayo Clinic, Arizona in the United States (a former HKU colleague), implemented a robust deep learning approach to predict disease-associated mutations of the metal-binding sites in a protein. This is the first deep learning approach for the prediction of disease-associated metal-relevant site mutations in metalloproteins, providing a new platform to tackle human diseases. The research findings were recently published in a top scientific journal Nature Machine Intelligence.

Metal ions play pivotal roles either structurally or functionally in the (patho)physiology of human biological systems. Metals such as zinc, iron and copper are essential for all lives and their concentration in cells must be strictly regulated. A deficiency or an excess of these physiological metal ions can cause severe disease in humans. It was discovered that a mutation in human genome are strongly associated with different diseases. If these mutations happen in the coding region of DNA, it might disrupt metal-binding sites of the proteins and consequently initiate severe diseases in humans. Understanding of disease-associated mutations at the metal-binding sites of proteins will facilitate discovery of new drugs.

The team first integrated omics data from different databases to build a comprehensive training dataset. By looking at the statistics from the collected data, the team found that different metals have different disease associations. A mutation in zinc-binding sites has a major role in breast, liver, kidney, immune system and prostate diseases. By contrast, the mutations in calcium- and magnesium-binding sites are associated with muscular and immune system diseases, respectively. For iron-binding sites, mutations are more associated with metabolic diseases. Furthermore, mutations of manganese- and copper-binding sites are associated with cardiovascular diseases with the latter being associated with nervous system disease as well. They used a novel approach to extract spatial features from the metal binding sites using an energy-based affinity grid map. These spatial features have been merged with physicochemical sequential features to train the model. The final results show using the spatial features enhanced the performance of the prediction with an area under the curve (AUC) of 0.90 and an accuracy of 0.82. Given the limited advanced techniques and platforms in the field of metallomics and metalloproteins, the proposed deep learning approach offers a method to integrate the experimental data with bioinformatics analysis. The approach will help scientist to predict DNA mutations which are associated with disease like cancer, cardiovascular diseases and genetic disorders.

Professor Sun said: Machine learning and AI play important roles in the current biological and chemical science. In my group we worked on metals in biology and medicine using integrative omics approach including metallomics and metalloproteomics, and we already produced a large amount of valuable data using in vivo/vitro experiments. We now develop an artificial intelligence approach based on deep learning to turn these raw data to valuable knowledge, leading to uncover secrets behind the diseases and to fight with them. I believe this novel deep learning approach can be used in other projects, which is undergoing in our laboratory.

This project was supported by the Research Grants Council (RGC) of Hong Kong and The University of Hong Kong (Norman and Cecilia Yip Professorship in Bioinorganic Chemistry).

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HKU scientists develop a deep learning approach to predict disease-associated mutations of the metal-binding sites - India Education Diary

Charlie Sheen invented never logging off – The Outline

To this day Im not sure how I created such chaos and wound up in that headspace, Charlie Sheen said in an interview this past April, reflecting on his infamous 2011 meltdown. Its as though there were some alien or demonic possession going on, he continued, evoking a kind of eldritch, body-invading nemesis in remembrance of his old months-long televised bender.

While surely figurative, Sheens contemporary rhetoric about his past is appropriate given the contrast of his recent form to that of eight years ago. Now he is so much more still and measured. He is not shaking, twitching, hyperbolizing, and arching his eyebrows disturbingly whenever he speaks. He is not, as he once was, proclaiming that he is winning while he clearly suffers.

He is calmer, now, because he is no longer on a ton of drugs and lying about it, and he is no longer the gleeful antihero in an absurd saga, about the lowering of standards for broadcasted human behavior. Sheens spectacular, protracted breakdown was similar to that of Howard Beales in Network, not in message (Im mad as hell, and Im not going to take it anymore) but in how thoroughly it exposed the lack of ethical foundation in media how little of a push the industry needed to turn into an unfettered clown show, a carousel of unwell men being pushed into worse and worse shape so that the public would never look away.

Charlie Sheen doing some good old-fashioned drugs in order to revel in his most manic and egotistical self after his dismissal from Two and a Half Men was not, in either a traditional or a for-the-public-good sense, a newsworthy event. Celebrity implosions had been manically covered for years, but Sheens breakdown came at an inflection point for media, showing how Wow, This Guy Is Actually Nuts would become a defining narrative structure in the years ahead, and how a collapsing protagonist could actively shape the way they were covered. In a few scant years, the rules had changed entirely: Imagine if Britney Spears, who suffered through an indefinitely cruel newscycle following a public breakdown in 2007, had the same media ecosystem, and could have told her story more her own way.

Whether or not it was Sheen who was somewhat randomly chosen by the meeting of technology and time, though, someone would soon be the face of this shift. The internets promise of utopian sprawl was beginning to wear off, as it narrowed into a limited collection of hegemonic data networks masked as community spaces. Much of the omni-directional energy that people brought online was being consolidated into the arenas of just a handful of tech giants, suddenly working on a scale large enough to disrupt traditional media and drastically change the way journalism works.

Sheen, too obviously fucked up to wittingly do much of anything, stepped into the eye of this hurricane, caused by the rising friction between a growing internet and old-school media institutions. This is when he again, not intentionally, because he was entirely too drunk and coked out to be calculating in this way began writing the blueprint for a new kind of fame, a pioneering form of burning out that has since taken regular boundless flight on Twitter. His 2011 bluster has, ever since, been endemic to the platform, embedded in its personality.

In 2011, social media was firmly on its path to cultural dominance but its presence was also still just a fraction of what it is today Twitters total userbase was less than a fifth of its current figure. The larger internets impact on what kind of stories would be reported was already real, however, and very presently becoming much realer. After he insulted showrunner Chuck Lorre in multiple interviews, in March CBS fired Sheen, then their highest-paid sitcom star at nearly $2 million per episode. They would quickly learn that they couldnt just make him go away. Sheen started a Twitter account during his breakdown, literally setting records for follower growth when he did, before even publishing a single tweet. Rivals NBC and ABC would soon air unhinged interview segments with Sheen, but only after demand for wacky-ass Sheen antics not just his posts, but his actual behavior was further created when he first broke his silence by talking to one of the very worst men to ever find success on the internet: Alex Jones.

On Jones InfoWars, an internet-first radio show centered around an angry and conspiratorial worldview that was gaining in FM syndication, Sheen talked of liv[ing] inside of a moment between a moment You either love, or you hate, and you must do so violently, he said. You have to hate everybody thats not in your family, because theyre there to destroy your family, and they will come at you in all forms and shapes. And therefore theres nothing in the middle. I dont live in the middle anymore, because thats where you get slaughtered, thats where you get embarrassed in front of the prom queen, and thats just not an option.

Its hard not to quote the entirety of the interview, a frankly beautiful burst of hubristic gibberish, a remarkable outpouring of the id of a famous person operating outside of their usually tightly controlled context. Youve got to work through your resentments, he said in an intentionally stupid voice, mocking the possibility of going to therapy. Yeah, no, he responded rudely to his own impression. Im going to hang onto them, and theyre going to fuel my attack. Theyre going to fuel the battle cry of my deadly and dangerous, secret and silent soldiers You thought you were just messing with one dude sorry: Winning, he exclaimed, birthing a catchphrase.

With Jones encouragement, Sheen went on to claim that Alcoholics Anonymous was a bootleg cult and that he quickly cured his alcohol and drug addiction with my brain. Then he called Thomas Jefferson a pussy. Next was TMZ, who sent a large man wearing a track jacket and a lot of hair gel to Sheens house for a 42-minute video interview in lawn chairs. During the interview, Sheen claimed he was 100 percent sober, but also took a whiff from a cup he was drinking out of and said you can smell the vodka.

It is, again, difficult not to share every word Sheen says through all of this, because every phrase from his mouth is a unique car crash of demented dude mantra; he was a warlock with tiger blood, he was a rock star from Mars, he was surrounded by goddesses (porn stars who lived with him, and who he suggests he paid to live with him), he was post-death, he had a different head and a different heart than anyone else, capable of enduring monstrous volumes of narcotics; he was a Vatican assassin; he was, himself, a drug that, if ingested, would cause children to weep over your corpse. He frantically leaned to and fro as he said these things about himself, twirling his fingers nervously, repeatedly leaving conversations with journalists to perform entire dialogues all by himself.

Saint Mary's Gaels fans hold up signs before the team's game against the Gonzaga Bulldogs in the championship game of the Zappos.com West Coast Conference Basketball tournament at the Orleans Arena March 7, 2011 in Las Vegas, Nevada. Photo by Ethan Miller/Getty Images

In the years that have followed, the Sheen-made tragicomedy has been streamlined, if not perfected. Twitter, in particular, has evolved into the quintessential podium on which to shuck all embarrassment and shame to say shiningly stupid things, to fast-growing audiences. It is the number one place where, if you happen to strike all the right chords of cognitive and cultural dissonance, you can make yourself into a soaring, eye-catching comet of bullshit.

Sometimes this tradition is intentional, knowing, ironic: dril, arguably the poet laureate of the medium, curates a feed that can often be described as a series of satirically cocksure micro-poems, delivered in the voice of a man who is falling but insists that hes rising. Other times, and more importantly, the sensation is actual, and can touch every end of the class spectrum. In recent times, weve seen an angry Long Island loser living in his van become a summer celebrity on Twitter, after going on a powerfully misogynistic rant in a bagel store, and NFL star Antonio Brown captivate the platform with some performative, empty chest-puffing against his team, all of which ultimately looked like a distraction from his soon-to-be-discovered abuse of women (something Sheen and Brown have in common). And of course, in the post-Sheen years, we have seen Donald Trump use the platform to rant Sheen-like as he grew a gnarly, racist political power on the platform that helped him become the president. The list gets longer: Kanye West, Roseane Barr, Azealia Banks, Jose Canseco, Heidi Montag, Ted Nugent, Alec Baldwin, Courtney Love, and many, many more have all used the platform to express an anger and lack of mental wellness thats reshaped our understanding of Celebrity.

A few of them, like Roseanne, actually experienced material professional consequences for publicly exploring the range of their inner noise. But mostly not: Like Sheen, these people were rewarded for their terrible, graceless behavior with a larger following. For the most part, famous people going off like this has increased attention for them in a way that can be monetized. The past decade of social media has made a weighty truth more true with each moment: no press is bad press. The fences between audiences and public figures (whether they already are a public figure, or about to become one with the right amount of online ballast) have collapsed mightily.

This, of course, is not precisely a bad thing the positive community gains of the internet, and the potential for more, are unspeakably large and worth plenty of optimism. But increased connective capacity has no intrinsic moral charge, in any direction, and requires cooperative, systemic stewardship. Without better institutional standards for passable online behavior, we will keep seeing wind advance the sails of bad people.

Alex Jones, a highly watchable person, kinetic and passionate and always unfathomable in his loud delusions, is an online character thoroughly in the vein of Sheen, expanding his internet presence immensely by losing his mind in an entertaining way. He also spreads lies to a hateful, radicalized audience, posing real public danger. His 2018 dismissal from all the major social media platforms gives us an example of how the webs overlords might deal differently with his form of internet-climbing a more advanced, pernicious form of the Sheen strain, to be sure over the course of the coming decade.

And we could probably all, as individuals, do less to enable Sheens upon Sheens, collectively leaning in to watch proudly performed pathologies, creating a culture that asks for more and more of them. Charlie Sheen was the seminal carrier of a cultural infection that has clearly spread, and a healthier future for the internet increasingly a synonym for the world depends in part on if we ever properly contain it.

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Charlie Sheen invented never logging off - The Outline