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Fake news isn’t the real problem news is: One of the world’s leading internet researchers explains what went wrong – Haaretz

Never in history have we had so much data at our disposal about human culture and behavior, says Lev Manovich, but as far as most artists and academics from the humanities are concerned, this data is capitalism, so its considered bad, because money is bad.

Manovich is one of the most important thinkers and researchers in the realms of the internet and digital culture today. His 2001 book The Language of New Media laid the theoretical foundations for what we now call digital studies, and helped create the terms we use to think and talk about culture in the digital age, first and foremost the concept of new media. A professor of computer science at the City University of New Yorks Graduate Center, Manovich says he sees himself not as an academic per se, but rather as an artist whose medium is academic articles. He also doesnt really get why people are still reading a book he published so long ago, and says, maybe the professors are just too lazy to read something else so they keep citing it and tell their students to read it too.

Manovich, 59, is hard to pin down. A self-proclaimed contrarian, hes critical of the academic world, although he has had an impressive run as both an academic and an artist, with a career that has in many senses shadowed the digital revolution he writes about prolifically. He began his career as a graphic designer in the 1980s, but is today credited with being one of the first to extend critical theory to the examination of software and its impact on society, and his interests range from digital aesthetics to cultural analysis of video games and analog radar systems. Hes also a digital artist with a keen interest in cinema, and was one of the first to teach and analyze digital filmmaking.

In recent years, Manovich has written a number of popular and academic studies of what he terms contemporary visual culture, which he defines very widely. This has included studying Instagram, and more recently, setting up a cultural analytics lab (based jointly at CUNY and at Caltech) that works with corporate giants like Google as well as such artistic institutions as the Museum of Modern Art to try to bring know-how from the world of computer science for example, the use of big data to the world of culture.For example, the lab analyzed almost 7.5 million Instagram photos that were shared in Manhattan and crossed-referenced them with demographics data to gauge how factors like inequality are reflected visually, in terms of what images are shared on the social media network. In another project, the lab created an interactive digital installation of the streets of New York City, based on 30 million images and data points collected from Instagram. Manovichs work at the MoMa is perhaps the most representative of his thought, and employs data-visualization methods to 20,000 photos held in the museums photography collection to try and used big data to yield cultural findings related to art history.

The underlying logic of his 30-year career can be seen as the attempt to reconcile two worlds that are seemingly irreconcilable: that of art and high culture, on the one hand, and that of computers and digital culture. Though one may seem aesthetic and artistic, and the other pragmatic and analytic, for Manovich, the digital revolution has linked them together: Computers have become the mediator of all of our cultural consumption, and software has become our artistic tool kit.

In the past, each art form had its own medium for expressing itself the photographer had his camera and the writer, his typewriter. Today, however, many forms of art and human creativity manifest almost exclusively through computer software. For Marshall McLuhan, the medium was the message because there were fundamental differences between television and books and radio. Today we live in a world in which films and television are consumed through Netflix, and music and podcasts through Spotify, both of which are accessed through a computer be it a smartphone app or an internet browser. For Manovich that means there are no longer different media as much as there is the new medium of software.

No human being writes anymore, Friedrich Kittler, the philosopher of technology, wrote in 1982, observing that, Today, human writing runs through inscriptions burnt into silicon.

Identity and politics

Manovich was born in 1960 in the Soviet Union, and raised in a Jewish household in Moscow: My parents were scientists and they were very secular, he says. He moved to the United States in the 1980s to complete his doctorate, at the University of Rochester, in visual and cultural studies. Therefore, one might assume that like other emigres from the USSR a younger member of that same cohort is Sergey Brin, co-founder of Google, who was born in 1973 Manovich is enamored of American culture. But thats not actually true: With Manovitch, nothing is black or white, and today he has returned to Russia (on sabbatical) to continue his cultural analytics project.

What I find terrifying is that intellectuals in America actually believe what they read in The New York Times, he says, which is to say they treat it as the gospel truth. Russia has many problems, however, Russia is outside of human rationality meanwhile, the U.S. is the most rational place in the world. When I came to America, I felt I was surrounded by robots.

Russia is a very complex country with lots of problems there are many spaces there where people still feel helpless, for example, the court system. But there are also lots of good things. For example, technologically, Moscow is very progressive, it has the best WiFi, Uber works great and Russia is the third-biggest country in terms of Instagram users. So its basically a contemporary country, but its also an authoritarian country so is China, by the way, but China is efficient and Russia is not.

But if you look at The New York Times, they only write about Russia from a negative perspective. So you want to know about the problem with fake news? Its the news is itself that is the problem, because its a very biased view of the world.

To Manovich, journalism is a flawed medium that we shouldnt fetishize. People assume the news is the truth and that fake news corrupted a perfect medium. He says, its not perfect, its flawed because of its business model, which incentivizes negative narratives.

The percentage of negative news is on the rise, he asserts, studies in the 1960s and 70s also found this. Why? Maybe because they need to sell advertisements, but intellectuals and other people think we are living in a time of crisis.

Guys! What crisis? Between 1940 and 1945 there was a crisis there was the Holocaust and the entire world was at war. Now there are only a few local conflicts we live in humanitys best period and every single indicator says so but the media create this sense that thats not true, and so people are depressed.

But nonetheless, the rise of Donald Trump, and Vladimir Putins growing global power create the sense that we are on the brink of a social or political crisis and that technology plays a key role in that.

But that has nothing to do with technology! Technology only reflects and permits cultural and social desires.

What do you mean? How does technology reflect social desires?

People want to feel safe, people want to neutralize uncertainty and increase predictability. And into this space, enters technology. Technology is very good at addressing human desires. For example: Authoritarian countries love technology because they love the idea of total control and total surveillance, and in China and Russia theyve embraced the internet more than anyone else.

The problem with this, according to Manovich, is the expectations we have of technology: Dont ask too much of technology and dont try to blame it for everything. In the 1990s, we lived in this optimistic decade, it was the end of the Cold War, the beginning of globalization, etc., and people projected these feelings onto technology and lots of left-wing thinkers, writers and journalists were writing about the internet as being connected to freedom so the internet was seen as a liberation project that works well with left-wing ideas. Twenty-five years later, we are now told that there is a massive social and political crisis, and people now project those feelings onto technology and blame it for that.

So loss of privacy and surveillance are not really a problem?

That is a misunderstanding and a problem of misplaced expectations: People really need to accept the fact that technology is not black or white, but part of our culture and our society. Every technology can be used in thousands of different ways. Just like you go out into the physical world and you see beauty and ugliness, life and death, love and hate. So for me, its the same with technology and the internet and even Facebook.

What is the biggest misunderstanding the general public has about the internet and technology?

Technology is seen as a mechanism that will allow for safety and predictability. So we put cameras everywhere and allow people to read our emails. But what Im trying to say is that the problem is not surveillance, the problem is that people want surveillance. And in some cases it works crime is down in some places because of these cameras. So its not all bad. For example, the Google Assistant does want to help me and make sure I reach my flight on time and it knows I have a flight because it reads my emails. It is in that sense that technology is very good at answering our desires, but the desire for stability and security through technology is the real problem: No one treats the internet as something to experiment with or something that can liberate anymore. Therefore, people are using it to create this very safe and predictable world that is closed and very conventional and it is very depressing.

The problem that occupies Manovich, is the conservative way people look at technology, and the fact that people from the arts and humanities no longer think about computers in creative ways, and even incite against big data instead of finding a way to wrest if from the hands of corporations for their own use.

The 1990s and early 2000s was a very activist period very idealistic, avant-garde, and people created things like Wikipedia. Today we have high-tech and big data but nobody is creating the next Wikipedia perhaps the best of online projects, which gave millions of people access to knowledge. So why is there no new Wikipedia today? Because society has changed and people realize you can make money from technology, not change the world, and thats what they are doing. I love the world, but I feel sad this is very reactionary, the professor says, adding, Think how great the ideas of the early internet thinkers were. People like Ted Nelson who thought about hypertext as a revolutionary force, or even someone like Vanevar Bush, who thought about organizing knowledge in a completely new way.

Both Nelson and Bush wrote texts about technologies that were never realized but that influenced generations of engineers and entrepreneurs. For example, in a seminal text published in The Atlantic in 1945, Bush, who headed headed the U.S. Office of Scientific Research and Development (OSRD), suggested creating a desktop system for storing and retrieving the wealth of information created by science. His so-called Memex system (a portmanteau of memory index) is considered a precursor to the desktop computer. Nelson, for his part, coined the term hypertext, as well as the idea of copy/paste, and envisaged a system called Xanadu, with interlinked pages, which foreshadowed the world wide web.

But at the end of the day, the digital revolution didnt actually create a revolution in knowledge like Bush and certainly like Nelson wanted. For example, Wikipedia is written by a relatively small group of predominantly male editors and it seems to me to have recreated many of the biases of the past despite promising to do the exact opposite.

What are you talking about! That is just not true. For millions of people, Wikipedia allowed access to knowledge for the first time. In Russia its used for intellectual debate.Listen, there were always utopian ideas; that is not new and that is not unique to our age and certainly not digital culture. All the problems with Wikipedia, for example, are problems that are related to humanity and have always been there. I wrote some articles on Wikipedia and now I feel ownership over it that is a human issue, not a technological [one].But the internet did something amazing and we in the West either forgot [that] or dont want to talk about that anymore.

China is a good counter example [of a digital revolution]: They built a big firewall, but at the same time, they also developed their own IT industry. They are the only country to do that [built their own discrete internet], and it works for them, and the educated middle class there likes the social credit system, for example [which is intended to give and make public scores on both financial credit and behavior for both individuals and businesses]. From a Western point of view that is very terrifying, but they are clearly saying, we want order and we have to give up some privacy and freedom for that order and at some level they are okay with that.

Life in a photoshopped society

I meet Manovich, a well-built and emotive man, at a stylish hotel in central Tel Aviv. Hes in town its his first time in Israel for the PrintScreen festival, and arrived courtesy of the U.S. Embassy in Israel. Which leads me to ask him if he feels Jewish, and if he had ever wanted to visit here before.

Im a Jew, so obviously I wanted to come to Israel, he says. I even have some family here, so its almost strange that I havent been here yet. But Ill also admit Im one of those Jews whos afraid of other Jews, you know? Like if theres too many of us in one place, someone may try to kill us. But its a strange thing, this idea of Jewish continuity.

Did you feel like you grew up with a Jewish identity?

There is no word I hate more than identity. Personally, yes, Im a proud Jew. My mother raised us to be proud of being Jewish and was proud that our family was living in Moscow from the 19th century, which is rare for Jews. On the other hand, I have never done those genetic tests, and they may be a lie. I dont know what I think about them and if there really is such a thing as a Jewish gene.

Obviously, there is no such thing! Do you not see a connection between genetic testing and identity politics? As if DNA can supply a scientific basis for identity?

Please be careful not to project your own ideas on to me when you write up this interview. I am not one of those intellectuals like [Slavoj] Zizek, who can talk about anything. I dont like talking about things that I havent thought about. But forget that. Im here because I want to fall in love with Tel Aviv and my condition for this interview is that you give me a good recommendation for a place to go out tonight. But I dont want to go to some bar with only teenagers where Ill feel old.

You should go to the Teder [entertainment compound]; its classic Tel Aviv and theres tons of places there, but you may feel old. Im 32 and I also feel a bit old there sometime. But Tel Aviv is amazing.

It feels like you guys are still in the 1990s technology and high-tech are still working for you.

Really? When did digital culture become a cultural force? In the 90s?

The big change came in 2005-2006 with social media. If in the 80s we had maybe 40 people in the entire world doing animation with computers, then today Adobe has 20 million users and there are about one billion photographers on Instagram.

In his 2013 book Software Takes Command, Manovich offers a historical and cultural analysis of software as a creative tool. I look at Photoshop filters like an art historian looks at the Mona Lisa, he says proudly today. Indeed, his book gives a detailed analysis of how Photoshops menu, for example, impacts digital photography ideas that today hes using to critique Instagram.

Do you feel digital culture is by definition a visual culture?

Yes, very much. Today you buy a phone and you are forced to become a photographer. That has both cultural and aesthetic significance. Because now suddenly everyones a photographer and there is an aesthetic that is a direct result of the technological forces behind these new media.

An example of those technological forces can be found in his book, where Manovich recounts how he traveled to South Korea to find the graphic design studio that did the illustrative shots that come with all of Samsungs phones. For him, this small studio in effect created the aesthetic language for an entire generation of photographers who use Samsung phone as a camera.

When I went to Seoul, I met my wife, who was probably the only person in South Korea who had had plastic surgery. When I was there I understood that this is a society that has been photoshopped an airbrushed society and therefore it makes sense they would create this aesthetic because they have this aesthetic of perfection.

Over the past few months, a number of South Korean K-pop stars have committed suicide, most recently Goo Hara, in her case after it was revealed that she had undergone plastic surgery. Is this the price of this aesthetic of perfection?

Maybe, but airbrushing is not new. Photography has always been airbrushed, technology only increases its precision and scale. For example, you look at the photos in old newspapers and they are so airbrushed that for us it looks almost like painting. Photoshop did not invent airbrushing, it only expanded its scale and increased its precision. The Photoshop revolution preserved this aesthetic quality but also made it more wide-scale and more accurate.

The same thing happened with Instagram and camera phones. Photoshop was used only by professional photographers they are the only ones who understood what I was writing about [in the late 1990s] because they felt the change Photoshop created in their field. Meanwhile, Instagram wanted to be used by the general public. But what actually happened? Five, six years into Instagram, all the photos there look super photoshopped everything is filtered and airbrushed, just now its automatic. But Photoshops influence on Instagram is just so clear, and today the goal of Instagram photos is that they look super professional and perfect even though it was set up as an attempt to democratize Photoshop and Flickr, which were scary and intended only for professional photographers.

Do you think Instagram actually democratized photography?

I dont know. If anything, it democratized beauty. But at the aesthetic level, this is a very dangerous thing, people get used to perfection and perfect images. Every picture you see online not to mention in print has been airbrushed and worked on. In the past 20 years, the desire for an aesthetics of perfection has also undergone a process of mass production. Today this aesthetic is actually preserved and enhanced not just through human behavior but also through algorithms and machine learning. When you swipe, you are sorting for the best picture and the algorithm only wants to [reinforce this by showing] you what you will click on, and that creates this situation.

In your most recent works, you have turned your focus to Instagram, attempting to treat it as an arena that is both artistic and big data. You asked: How can I look at a billion photographs at the same time and try to reach some aesthetic or cultural understanding. Do you think the age of human aesthetics is over and now we only have big data aesthetics?

That is not what I think at all and really dont want you to project your own ideas about this post-subject aesthetic onto me. I will give you an answer that will surprise you, because we are both smart Jews: My next text is not about the attempt to look at a million photographs but rather only at one. I want to write about one single Instagram photo and dedicate 60 pages to it.

Why?

Because I want to write about things that move us and I think that today content matters more than ever. Computers cannot see what makes a photograph beautiful and thats what interests me. Today people seem to think that there are too many photos, too many posts, and that content doesnt matter. I think the opposite. Now content matters more than ever before. The single frame, the single post or even a book the perfection of each of these is more important because the competition is so big. People are looking for a point of orientation to grab onto and a book is just such an orienting point.

If I write a book that is good and people read it then that means that it has succeeded despite there being so many blog posts and articles out there. Look at Yuval Noah Harari I dont know if what he writes is actually good scientifically but people are interested in what he has to say, and that is amazing. People read him all over the world.

And what about digital culture and data? Why arent people more interested in that?

Maybe if Id write about money, like [Thomas] Pikkety, and not about culture, people would be more interested and Id be more successful. But forget about that, its not just software and digital culture its data. Ill give you an example. I gave a lecture to PhD students in art and art history; these are the people who are going to go on to become curators at the MoMa and so on. And I tell them about my research into Instagram and they listen politely but at the end of my talk, they ask me: Why are you wasting your time on Instagram, its not art. So I say: What are you talking about, Im interested in contemporary visual culture and thats where its happening.

Do you understand? There are a billion people using Instagram, but for those students, its capitalism and corporations, so its bad and all these people using Instagram are just living in false consciousness. That the only perspective for examining Instagram is not as art or culture, but as an ideology. For them Instagram is just an instrument of ideology, but I hate that bullshit.

Come on, not all of academia is that Marxist. There are social studies that do focus on digital culture.

Of course, but you need to understand that today there are two types or schools of social sciences: the one done at universities, and the one done by corporations. They both miss something, in some sense. Humanities and social sciences only focus on diversity, inclusion and identity trying to challenge the Western canon which is very important and actually great, but its a really bad way to research Instagram and think about software culture. Why? Because it treats these things as capitalistic. And therefore in some strange way, I find myself on the side of the corporations, because they do analysis of human behavior. But there is a massive difference between what Google and Amazon do and what academia does: First of all, they dont publish their results, but more importantly, they have 5,000 data points about every person but they only ask one question: Will they buy something? They look at this data for purely commercial reasons. So Im stuck in this weird position and feel a certain discomfort.

Do you think the digital revolution skipped over the humanities and social sciences?

When did Western society really start thinking critically about itself? Yes, theres Descartes, but during the 18th and 19th centuries, we have this golden age of thought. From Marx to Weber and Freud and Durkheim. All this intellectual output was devoid of data, and toward the 1990s, you start to have this sense that everything that can be thought of has already been thought of. There is this intellectual exhaustion, almost, in academia and in what I call high culture. No one thinks about social structures anymore, no one even thinks about the structure of text anymore. There are no big ontological or social theories anymore except with some giants like [philosopher of science] Bruno Latour, but even he limits himself to talking only about science.

That is the paradox of our time: We can have all the information in the world about everyone with an internet connection, and in the future we will even be able to see what people are reading and even view their brains thinking or reading in real time so you can look at society at scale and in resolutions that in the past were impossible, but it hasnt led to any new theory or research. We have all this big data but we dont really know what to do with it, and we think about it and use it with 19th-century methods. For example, Excel is amazing but spreadsheets have existed since the 19th century and are [an example of] classic capitalistic cognition. I want to tell people to think about data in artistic and creative ways.

You also have a revolutionary project it seems. Do you also want to change the world?

Maybe you are right. My goal is to get people to think about technology differently, to think about digital culture in a less rigid way, and get people to think less in stereotypes. I want to make them see the world in a more complex way because thats the way I see the world. In this sense, I do have a left-wing project but its not connected to changing the world, but rather to a desire to make people more open. In that sense, Im actually more of a contrarian.

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Fake news isn't the real problem news is: One of the world's leading internet researchers explains what went wrong - Haaretz

Advances in Bispecific Antibody Development are Leading to an Evolution in Anti-cancer Drugs – OncoZine

The concept of using bispecific antibodies for tumor therapy has been developed more than 30 years ago with many initial struggles. However, new developments such as sophisticated molecular design and genetic engineering have helped tremendously in solving many technical challenges and created the next generation bispecific antibodies with high efficacy and safety profiles.

With many successes recently, the zoo of bispecific antibodies now consists of more than 100 different formats, and about 80 bispecific antibodies are currently in clinical trials.

KEYNOTE PRESENTATION: Current Landscape and Outlook of Bispecific Antibody

Roland Kontermann, PhD, Professor, Biomedical Engineering, Institute of Cell Biology and Immunology, University of Stuttgart

Bispecific antibodies have experienced a dramatic interest and growth for therapeutic applications, with more than 80 molecules in clinical development; e.g., in oncology, immuno-oncology, but also for non-oncology applications. An overview will be given on the making of bispecific antibodies and the various therapeutic concepts and applications, e.g., for dual targeting strategies, retargeting of immune effector cells, and substitution therapy by mimicking the function of natural proteins.

Functional Screening Unlocks the Therapeutic Potential of Bispecific Antibodies

Mark Throsby, PhD, CSO, Merus NV

Case studies of clinical assets will be discussed that highlight the role of empirical functional screening. Examples will include both I-O and targeted therapies demonstrating that diverse functional readouts can be incorporated into bispecific antibodies screens.

Selection-Based Development of a Heavy Chain-Light Chain Pairing Technology

Paul Widboom, PhD, Associate Director, Antibody Discovery, Adimab LLC

A significant challenge in the development of multivalent bispecific antibodies involves solving the heavy chain-light chain pairing problem. While most heavy chain-light chain pairs possess a preference for their cognate partner, noncognate mispairing occurs. Avoiding these undesired mispairs is a relevant challenge in the field of bispecific antibody manufacturing. Here we present a solution to the heavy chain-light chain problem derived from a novel selection system. This system finds mutations that improve cognate heavy chain-light chain pairing while maintaining antigen binding affinity.

A Novel Class of Fully Human Co-Stimulatory Bispecific Antibodies for Cancer Immunotherapy

Dimitris Skokos, PhD, Director, Immunity & Inflammation, Regeneron Pharmaceuticals

T-cell activation is initiated upon binding of the T-cell receptor (TCR)/CD3 complex to peptide-MHC complexes (signal 1); activation is then enhanced by engagement of a second co-stimulatory receptor, such as the CD28 receptor on T cells binding to its cognate ligand(s) on the target cell (signal 2). Recently described CD3-based bispecific antibodies act by replacing conventional signal 1, linking T cells to tumor cells by binding a tumor-specific antigen (TSA) with one arm of the bispecific, and bridging to TCR/CD3 with the other.

Next-Generation Bispecifics for Cancer Immunotherapy

Michelle Morrow, PhD, Vice President, Preclinical Translational Pharmacology, F-star

The use of bispecific antibodies can potentially modulate anti-tumour immune responses. Bispecific antibodies: an attractive alternative to cancer treatment combinations. F-stars approach to create bispecific mAb. In vitro and in vivo efficacy of F-star bispecific antibodies targeting oncology pathways observed in preclinical studies.

Bispecific Gamma Delta T Cell Engagers for Cancer Immunotherapy

Hans van der Vliet, MD, PhD, CSO, LAVA Therapeutics; Medical Oncologist, Amsterdam UMC

V9V2 T cells constitute the largest T cell subset in human peripheral blood and are powerful anti-tumor immune effector cells that can be identified in many different tumor types. This presentation will discuss bispecific antibodies designed to engage V9V2 T cells and their use for cancer immunotherapy.

Combinatorial Approaches to Enhance Bispecific Anti-Tumor Efficacy

Eric Smith, PhD, Senior Director, Bispecific Antibodies, Regeneron Pharmaceuticals

This presentation will describe Regenerons bispecific platform and present preclinical data on REGN4018, a clinical stage T cell engaging bispecific targeting Muc16 for solid tumor indications. In addition, status updates on Regenerons other clinical stage bispecific antibodies (REGN1979, REGN5458, REGN5678) will be presented as well as a discussion of new combinatorial approaches being taken to enhance bispecific anti-tumor efficacy.

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Advances in Bispecific Antibody Development are Leading to an Evolution in Anti-cancer Drugs - OncoZine

Global Immunofluorescence Laser Capture Microdissection Equipment Market Forecast to 2024 Thermo Fisher Scientific, Inc. (US) – Market Reports…

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Bates biochemist and physicist receive $373,000 for Lyme research – Bates News

Two Bates College scientists have received nearly $373,000 from the National Institutes of Health for first-of-its-kind research into the genetic functioning of bacteria that cause Lyme disease.

The project draws on new capabilities in high-resolution microscopy that make it possible to observe spatial arrangements of RNA in Borrelia burgdorferi, one of four Borrelia species that cause Lyme disease. This study of variations in RNA location and shape could eventually suggest new medical responses to Lyme, which strikes up to 300,000 people in the U.S. annually.

Receiving the $372,639 grant for the two-year project are physicist Travis Gould, an expert in the field of fluorescence nanoscopy, and biochemist Paula Schlax, who researches gene expression in spiral-shaped bacteria, also known as spirochetes, such as Lyme bacteria.

Biochemist Paula Schlax and physicist Travis Gould pose with Goulds STED super-resolution microscope in Carnegie Science Hall. (Phyllis Graber Jensen/Bates College)

RNA is an intermediate in the process of cells making proteins, says Schlax, a professor of chemistry and biochemistry at Bates. Were trying to understand generally how production of proteins gets turned on and off when the bacteria move from ticks to mammals and from mammals back to ticks changes in the bacterias environment that change the shape and location of RNA.

We know from other bacteria that RNAs location inside the cell seems to affect how long that RNA lasts whether its near the edges of the cell, or the ends of the cell, or spread out evenly inside. Our hypothesis is that how fast RNA gets broken down, or doesnt get broken down, probably helps the cell decide which proteins to make when conditions change, such as when the bacteria moves from the tick to a mammal or vice versa.

Variations in protein production could cause variations in the bacterias disease-causing capability. The more we understand that process, Schlax says, the easier it is to think about new targets for drugs and new therapeutics.

Until quite recently, the physical limitations of microscope technology curtailed its usefulness in testing such a hypothesis. The bacteria have a characteristic shape, says Gould: very skinny in relation to length. The length is typically around 20 microns, or millionths of a meter, but the bacterias internal diameter is vastly smaller, at about 200 nanometers, or billionths of a meter. (A piece of paper is about 100,000 nanometers thick.)

That 200 nanometers is, in the best-case scenario, at the limit of a conventional microscopes resolution, Gould says. So a conventional microscope cant answer these questions about where RNA is within that 200-nanometer cylinder.

But Gould, an associate professor of physics, is an innovator in imaging technologies that use lasers, fluorescing molecules, and other means to attain much higher resolution. For the NIH-funded research, he has adapted an existing Bates microscope that he built and that uses a process called stimulated emission depletion, or STED, to capture images of the B. burgdorferi RNA.

Going from older microscopy technologies to Goulds newly updated STED is like putting on glasses for the first time.

Specifically, he added another laser to the instrument that expands its imaging capability from two to three dimensions. Going from older technologies to this latest iteration, says Schlax, is like putting on glasses for the first time.

Complementary to the STED technology, the researchers and their students will use a technique called fluorescence in situ hybridization (FISH) that deploys fluorescent probes to specific parts of the transcripts that the microbes DNA imparts to its RNA.

The research will be the first to identify patterns of transcript localization within B. burgdorferi, and, notably, the first research to use STED microscopy for this sort of localization within any spirochete.

This is significant given the range and impact of diseases caused by such bacteria, including syphilis, yaws, periodontal disease, and leptospirosis, whose effects include kidney failure.

Joining Schlax and Gould in the project are Bates students and research associate Anna Bowsher, whose position is funded by the NIH grant. The work entails growing B. burgdorferi microbes in the lab, affixing individual cells to slides, and introducing DNA molecules, complete with fluorescent tags, that are tailored to activate a specific RNA response.

Then the slides will be examined with Goulds STED microscope, and the results compiled into a spatial-distribution analysis of different types of RNAs. The team hopes that they will have results to report by summer 2020.

The project will involve both thesis students advised by Gould and Schlax and students doing summer research. These kinds of projects really are great for students to see how science is done, says Schlax, and hopefully get their names on some papers and keep them interested in science.

With the use of fluorescing molecules now standard practice in high-resolution microscopy, STED imaging achieves enhanced resolution through a technique of selectively switching off such molecules. STED is one of a number of so-called super-resolution techniques developed to bypass the diffraction limit, a limit on the resolution of conventional microscopy imposed by the length of light waves.

Gould estimates that all told, there are likely two dozen or so labs equipped with commercially available STED microscopes, and another handful that use custom-built instruments like his.

Excerpt from:
Bates biochemist and physicist receive $373,000 for Lyme research - Bates News

Assistant Professor for the Department of Biochemistry, Faculty of Science, Masaryk University job with MASARYK UNIVERSITY | 190218 – Times Higher…

Department Department of BiochemistryFaculty of Science

Deadline 20 Jan 2020

Start date 20.02.2020 (upon agreement)

O P E N P OSI T IO N

Assistant professor for the Department of Biochemistry, Faculty of Science, Masaryk University

Dean of the Faculty of Science, Masaryk University opens the selection procedure for the position ofAssistant professor for the Department of Biochemistry.

Deadline: 20.01.2020Starting date: 20.02.2020 (upon agreement)

Requirements:

Application form with attached motivation letter, curriculum vitae, scanned certificates of education and overview of professional activities should be send till20.01.2020to the Personnel Office, Faculty of Science, Masaryk University, Kotlsk 2,61137 Brno using the electronic application form.

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Assistant Professor for the Department of Biochemistry, Faculty of Science, Masaryk University job with MASARYK UNIVERSITY | 190218 - Times Higher...

Wiped Film Evaporators (WFE) Market growth in technological innovation, Competitive landscape mapping the trends and outlook for next 5 years LCI…

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Metabolic dysregulation: origins of neurodegenerative disease – Health Europa

A new study, published in the journal Neuron, implicates metabolic dysregulation in neurodegenerative diseases leading to altered calcium homeostasis in neurons as the underlying cause of cerebellar ataxias.

This study not only tells us about how SCA7 begins at a basic mechanistic level, but it also provides a variety of therapeutic opportunities to treat SCA7 and other ataxias, said Al La Spada, MD, PhD, professor of Neurology, Neurobiology, and Cell Biology, at the Duke School of Medicine, and the studys senior author.

SCA7 is an inherited neurodegenerative disorder that causes progressive problems with vision, movement, and balance. Individuals with SCA7 have CAG-polyglutamine repeat expansions in one of their genes; these expansions lead to progressive neuronal death in the cerebellum. SCA7 has no cure or disease-modifying therapies.

La Spada and colleagues performed transcriptome analysis on mice living with SCA7. These mice displayed down-regulation of genes that controlled calcium flux and abnormal calcium-dependent membrane excitability in neurons in their cerebellum.

La Spadas team also linked dysfunction of the protein Sirtuin 1 (Sirt1) in the development of cerebellar ataxia. Sirt1 is a master regulator protein associated both with improved neuronal health and with reduced overall neurodegenerative effects associated with aging.La Spadas team observed reduced activity of Sirt1 in SCA7 mice; this reduced activity was associated with depletion of NAD+, a molecule important for metabolic functions and for catalysing the activity of numerous enzymes, including Sirt1.

When the team crossed mouse models of SCA7 with Sirt1 transgenic mice, they found improvements in cerebellar degeneration, calcium flux defects, and membrane excitability. They also found that NAD+ repletion rescued SCA7 disease phenotypes in both mouse models and human stem cell-derived neurons from patients.

These findings elucidate Sirt1s role in neuroprotection by promoting calcium regulation and describe changes in NAD+ metabolism that reduce the activity of Sirt1 in neurodegenerative disease.

Colleen Stoyas, PhD, first author of the study, and a postdoctoral fellow at the Genomics Institute of the Novartis Research Foundation in San Diego, said: Sirt1 has been known to be neuroprotective, but its a little unclear as to why.

Tying NAD+ metabolism and Sirt1 activity to a crucial neuronal functional pathway offers a handful of ways to intervene that could be potentially useful and practical to patients.

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Metabolic dysregulation: origins of neurodegenerative disease - Health Europa

What is ‘dopamine fasting’? How some are trying to change their brains – TODAY

As interest in intermittent fasting keeps growing, a completely different type of fasting trend is coming out of Silicon Valley. Followers of "dopamine fasting" believe that if they deprive themselves from anything stimulating devices, movies, TV, light or even other people they can alter the levels of dopamine in their bodies and reset their brains.

On the surface, it's a life hack that sounds like a good idea: try to modify the dopamine chemical known as one of the "happy hormones" in the body simply by unplugging from devices and stepping away from activity.

"Dopamine fasting is like, 'I'm getting off my devices so I can feel more,'" Dr. Zach Freyberg, an assistant professor of psychiatry and cell biology at the University of Pittsburgh, told TODAY. "It's doing things that are that are meant to keep you sensitized to the world around you."

To fast, followers say they avoid things they enjoy, which can include mobile devices, sex, social media, entertainment, shopping, gambling, exercise, food and alcohol, for a set period of time. Some might even avoid eye contact or chats during that time.

The goal avoiding stimulation in the present, in order to be happier later. For example, love online shopping? During a fast, you'd skip it.

In a way, it's like meditation where people spend time without outside excitement. But this type of fasting is tailored to what specifically causes your dopamine to spike, whether it's red wine, Snapchat or Christmas movies.

Sounds simple, right? Not really.

Your brain is always working. Your neurotransmitters, like dopamine, are always working, Madelyn Fernstrom, a neuroscientist and NBC News health and nutrition editor, told TODAY.

While dopamine fasting focuses on the molecule's role as a neurotransmitter in the brain, dopamine does a lot of heavy lifting throughout the body.

Dopamine is something that's inside of our bodies that our bodies make, Freyberg said. In the brain, dopamine is responsible for lots of important brain functions. You need it to help control mood, you need that to feel a sense of satisfaction and reward.

Trending stories,celebrity news and all the best of TODAY.

People often think of it as the hormone of excitement and novelty seeking, said Dr. Amit Sood, executive director of the Resilient Option, and former professor of medicine at Mayo Clinic.

This means people experience a surge of it when they try something new or anticipate something. Some of what Silicon Valley sells causes dopamine spikes.

A lot of social media is driven by dopamine, he said. Youre just chasing it.

But dopamines role is much more complex. It also helps the brain control movement and exists in other parts of the body, regulating insulin, aiding digestion, managing kidney function and maintaining blood pressure.

Its kind of like an air traffic coordinator. It controls and coordinates the functions of a lot of different organs, a lot of different parts of the body, to make sure they work harmoniously, Fryberg explained.

Not having enough dopamine causes real problems. Parkinsons disease, for example, is a disorder of dopamine, Fryberg said.

The body absolutely needs to make that dopamine because it needs to control the life support systems, he said.

In some ways, eating and exercising can influence dopamine production, but not in the way that dopamine fasting fans think.

When you eat, the amount of dopamine in your blood stream temporarily goes up because that helps control insulin, Fryberg said. There's more and more evidence that exercise can help in Parkinson's patients preserve the amount of dopamine in the brain.

Beyond that that's all we know, he said.

The experts agree that even if the name is an oversimplification of how brain chemistry works, the concept behind dopamine fasting is positive. What "fasters" are truly proposing is taking a break from stimulation and being mindful both healthy practices.

There is no downside, unless you believe you are having an immediate impact on your brain chemistry, Fernstrom, a nutrition scientist, said. It is mistake to think that a short-term behavior of any kind is going to be having an impact on your brain.

Whats more, unplugging and spending time without stimulation might have an opposite effect than anticipated.

Meditation has been shown to increase dopamine in the brain reward activity center, Sood said.

While meditation and avoiding devices is beneficial, Sood encourages people to think of it as adding something to life not subtracting.

It is very difficult to empty your life of something, he said. I tried emptying my mind and it doesnt work. It is not about emptying it. Its about filling it with the right things.

That's why he suggests that people think of something positive while stepping away from devices and overactivity.

If you meditate on gratitude or compassion or kindness it will be more effective, Sood said.

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What is 'dopamine fasting'? How some are trying to change their brains - TODAY

The Science News that Shaped 2019 – The Scientist

Discovery of a new T cell

With all the extensive investigations scientists have conducted of the human immune system over the past century, it is astonishing that there are still new cell types to be found. Yet in May, researchers described a hybrid of B and T cells, which they named dual expresser (DE) cells, in people with type 1 diabetes. We think [the DE cell peptide may play] a very major role during the initial phase of the disease, Abdel Hamad, an immunologist at Johns Hopkins University School of Medicine and the senior author of the study, told The Scientist at the time.

That same month, scientists also reported that humans natural killer cells, thought to form the innate immune response, can also keep memories of past encounters with offending antigens, much like the adaptive immune response does. The discovery challenges the basic dogma of how these cells functionanother reminder there is still so much unknown even in our own blood.

Measles, Ebola, and polio flared up in 2019. Cases of measles in the US were the highest since the virus was declared eradicated in America in 2000, and they have been soaring in Europe and elsewhere. Public health officials say insufficient immunization, fueled by anti-vaccine sentiment, is to blame. All the while, scientists continued to learn about the virusand just how dangerous it is. In October, researchers reported that infection with the virus that causes measles appears to leave the immune system vulnerable to infections by other pathogens.

Thousands of people died of measles this year in Democratic Republic of Congo, where an outbreak of Ebola has also been ongoing since the 2018. Violence in the region has hampered efforts to get the Ebola epidemic under control, but newly developed drugs and vaccines administered this year may help slow Ebolas spread.

Polio will soon have another vaccine to contend with as researchers have developed one to designed to counteract the failure of an older vaccine that allowed the virus to continue to circulate and eventually revert to virulence. Such vaccine-derived polio cases have now become more common than those caused by the wild virus, but the new vaccine, which is genetically engineered to avoid such reversion, is set to be deployed in 2020.

The long-term price we pay for having a chilly research environment far exceeds that of the few ideas stolen from us.

Alice Huang, CaltechFears of espionage

Federal science agencies have been cracking down on researchers who violate the rules for relationships with foreign governments, in an effort to prevent other countries from stealing US intellectual property. An eye doctor at the University of California, San Diego, cancer researchers at MD Anderson Cancer Center, geneticists at Emory University, and the leaders of Moffitt Cancer Center in Florida are among those have lost their jobs because of their ties to China.

As the US government moves to strengthen defenses against espionage, researchers have voiced concerns of racial profiling, specifically, that Chinese and Chinese-American scientists will be unfairly scrutinized. Writing to The Scientist in March, Caltech biologist Alice Huang says, The long-term price we pay for having a chilly research environment far exceeds that of the few ideas stolen from us.

To avoid legal issues, researchers from Spain and the US developed the first human-monkey chimeras in China, a Spanish newspaper reported in July. The embryos development was stalled after a few weeks, but the scientists would like to grow animals whose organs could be harvested for human transplant, a goal at least one expert finds impractical. I always made the case that it doesnt make sense to use a primate for that. Typically they are very small, and they take too long to develop, Pablo Ross, a veterinary researcher at the University of California, Davis, told MIT Technology Review.

While still illegal to pursue in the US using federal research funds, human-animal chimera projects got the regulatory green light in Japan last spring. Its good that they now allow people to do human-animal [chimera embryos] with species like pigs and sheep, Sean Wu, a developmental biologist at Stanford University, told The Scientist in April. But human-primate chimeras are a different, um, animal. Theres just too many things we dont know about when you try to chimerize two species that are so close to each other, like humans with nonhuman primates.

Teeth of the newly named hominin Homo luzonensis

CALLAO CAVE ARCHAEOLOGY PROJECT

Speaking of new humans, scientists described an entirely new species of Homo, H. luzonensis, this year. The first bone of our newly named cousin was originally dug up in Callao Cave in the Philippines in 2007, but back then it wasnt clear who exactly it belonged to. The discovery of more bones and teeth led scientists to conclude that the individuals were a distinct species. Its fantastic news. Its not every day you get to name a new species within the human family tree, Michael Petraglia, a professor of human evolution and prehistory at the Max Planck Institute for the Science of Human History who wasnt involved in the study, told The Scientist at the time.

The friendships that convicted sex offender Jeffrey Epstein had forged with scientists, and the money he gave them for research, caused an uproar this year. Scholars quit their jobs at MIT in protest while some universities pledged to redirect the money to charitable causes.

At the same time, the Sackler family (of oxycontin-maker Purdue Pharma) came under heightened scrutiny for their role in the opioid epidemic. The Sacklers have been big donors to biomedical research over the years, and Tufts University recently decided to strip the Sackler name from its campus buildings.

Thanks to the work of survivors and activists, #metoos momentum carried through in 2019. Scientific conference organizers were forced to reflect on their policies for protecting attendees, especially in the archaeology field after a known harasserbanned from his own campus where he had been a professor for decadesshowed up at the Society for Archaeology meeting in Albuquerque this year. Victims of David Yesner were present at the meeting and alerted staff, but the societys response was inadequate, causing a prompt backlash on social media and a longer-term reckoning that has since resulted in a more-solidified policy. Members of the SAA voted to allow board members to ban convicted harassers from attending meetings.

The glycan (upper left) and RNA (lower right) are connected by an unknown intermediary in this possible structure of glycoRNA.

RYAN FLYNN

Although still in preprint form, results published this fall introduced a new aspect to cell biology: glycoRNAs, or noncoding RNA strung with complex sugars called glycans. Glycans are normally sequestered in the endoplasmic reticulum and Golgi bodies, away from RNA in the cytoplasm and nucleus. There really is no framework in biology as we know it today that would explain how RNA and glycans could ever be in the same place at the same time, much less be connected to each other, senior author Carolyn Bertozzi, a chemical biologist at Stanford University, told The Scientist in October. Whatever it is, its a completely unknown biology. Expect to see more insight into this mysterious new cellular entityits function, its structure, and its prevalence.

A wave of pulmonary illnesses and deaths related to vaping swept across the US this year. It wasnt clear to clinicians at first why these cases were appearing, but months of sleuthing led investigators to conclude that vitamin E acetate added to products, especially counterfeit liquids containing THC, was a possible culprit. The Centers for Disease Control and Prevention is continuing to investigate, as more ingredients may be to blame.

Researchers doubled DNAs alphabet this year with the development of two new synthetic nucleotides, adding to two created previously, leading to what they call a hachimoji DNA molecule composed of four synthetic and four natural bases. The DNA successfully transcribed hachimoji RNA using a bacteriophage RNA polymerase. This is really an exciting paper . . . a true engineering feat, Northwestern Universitys Michael Jewett, who was not involved with the research, wrote in an email to The Scientist in February.

Kerry Grens is a senior editor and the news director of The Scientist. Email her at kgrens@the-scientist.com.

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The Science News that Shaped 2019 - The Scientist

Vaping May Increase the Risk of Chronic Respiratory Disease – Scientific American

A recent outbreak of deadly lung illnesses linked to vaping has put the practice in health professionals and regulators crosshairs. Now the first longitudinal population-based study of e-cigarette use in a representative sample of U.S. adults suggests it increases the risk of many chronic lung illnesses, tooespecially when combined with smoking combustible tobacco.

Most of the media coverage of vaping has focused on the short-term, or acute, health impacts. More than 2,500 cases of e-cigarette, or vaping, product useassociated lung injury (EVALI) have been reported across all 50 states and the District of Columbia, as well as in Puerto Rico and the U.S. Virgin Islands; 54 deaths have been confirmed to date. Black market productscontaining THC (the primary psychoactive ingredient in marijuana were the mostly commonly reported by EVALI patients, buthealth authorities have not ruled out risks of lung injury from other vape products.*

The new research suggests that e-cigarettes may also cause long-term health problems. The study, published this week in the American Journal of Preventive Medicine, found that people who reported using the devices were more likely to develop lung illnesses such as chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema or asthma. E-cigarettes have been touted as a harm-reduction method for helping smokers quit, and the new findings could challenge that.

One of the problems that we've had with the whole e-cigarette debate is its asking this abstract question: Are e-cigarettes less dangerous than cigarettes? The answer to that is: if youre a never smoker who never vaped, the e-cigarettes arent as bad as the cigarettes, says study co-author Stanton Glantz, a professor of medicine at the University of California, San Francisco. But in the real world, most adult e-cigarette users are dual [e-cigarette and combustible tobacco] usersand thats worse than [just] smoking.

Like conventional cigarettes, e-cigarettes contain nicotine and various toxic substances that have been shown to disrupt lung function. But e-cigarettes also contain material such as propylene glycol, flavorings such as diacetyl (for a butter taste) and cinnamaldehyde (for cinnamon), as well as heavy metals. Previous studies in animals have shown that exposure to e-cigarette vapor is linked to lung inflammation and depressed immune activity, and repeated exposure appears to cause lung damage that resembles COPD. Most of the studies in humans have been observational, but they have found an association between e-cigarette use and respiratory disease. And a longitudinal study of people with COPD found that smoking e-cigarettes was linked to exacerbations of the disease and a faster decline.

In the new study, Glantz and his U.C.S.F. colleague Dharma Bhatta analyzed data from the Population Assessment of Tobacco and Health (PATH) Study, a longitudinal study of adult tobacco use and health in the U.S. They used data collected from three consecutive time points, or waves, between 2013 and 2016. Respondents were asked whether they currently or previously used e-cigarettes or combustible tobacco (including cigarettes, cigars or cigarillos), or both, as well as whether they had ever been diagnosed with COPD, chronic bronchitis, emphysema or asthma.

Glantz and Bhatta found that people who reported being current or former e-cigarette users at Wave 1 of the study had about a 30 percent higher risk of developing a respiratory disease at Waves 2 and 3, compared with people who had never used the devices. This danger was not as dire as that of current tobacco smokers at Wave 1, who had about a two-and-half-times higher chance of respiratory illness in later waves. But people who used both e-cigarettes and combustible tobacco had the greatest riskthey were 3.3 times as likely to develop a respiratory disease as someone who had never smoked or used e-cigarettes. The findings suggest e-cigarette use is a risk factor for respiratory disease independent of conventional smoking.

Robert Tarran, a professor of cell biology and physiology at the University of North Carolina at Chapel Hill, who was not involved with the paper, says the findings were not all that surprisingbut the fact that this was a longitudinal study strengthens what previous observational ones have found. It basically confirms what people in the field were thinking, which is that vaping isnt good for you, Tarran says. He and his colleagues published a study earlier this year that found that vapers had elevated levels of proteases (proteins that cut up other proteins) in their lungs. Such elevated levelssimilar to those seen in smokerscan lead to emphysema. And just as it can take a long time for the effects of smoking to cause serious disease, we're kind of concerned that with vapers, youre going to see a similar thing, where kids who start vaping now40 to 50 years from now, there's going to be a big epidemic of COPD and lung cancer, Tarran says.

Glantz says he was somewhat surprised that he and Bhatta could detect the increased disease risk in just two yearsthe length of time over which people were tracked in the PATH Study. They also calculated whether switching completely from conventional smoking to e-cigarettes lowered the risk of disease and found that it did. Almost none of the people who used e-cigarettes at Waves 2 and 3 of the study had stopped smoking combustible tobacco, however. Instead smoking both e-cigarettes and combustible tobaccoso-called dual usewas much more common.

Last week, a group of public health researchers published an opinion piece in Science arguing that policies seeking to restrict or ban vaping may be counterproductive, because many adult smokers rely on e-cigarettes to help them quit smoking. But the new findings could undermine this view. The concept that smokers would transition from using cigarettes to e-cigarettes and substantially reduce their health risks is not a crazy idea, says Glantz, who is also a nonsmokers rights activist. But if you look at actual use behaviors, they multiply. And since most people are dual users, youre getting increased harms. In addition, there is the fact that millions of young people who are not regular smokers are getting addicted to e-cigarettes, he adds. (Scientific American reached out to e-cigarette company JUUL Labs and the Vapor Technology Association, a vaping industry trade organization, for comment but did not receive a response.)

The mechanism of lung damage with chronic e-cigarette use is probably different from that behind EVALI, Glantz notes. About 80 percent of those hospitalized in the EVALI outbreak reported vaping THC, and the lung damage in those patients resembled that caused by chemical burns. The U.S. Centers for Disease Control and Prevention has identified vitamin E acetatea type of oil used as a thickening agent in some THC vaping productsas a possible chemical of concern, although the agency is exploring other possible mechanisms.

The PATH Study was focused mainly on tobacco use and did not distinguish between use of nicotine and marijuana e-cigarettes, Glantz says, adding, If had to do it over again, Id include marijuana in the model.

Regardless of whether vaping involves THC or nicotine, though, neither are probably good for the lungs, according to Glantz, adding, As my pulmonologist friends say, lungs are designed to inhale air.

*Editors Note (12/20/19):This article was updated to clarify that most of the products associated with the EVALI outbreak were black-market products.

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Vaping May Increase the Risk of Chronic Respiratory Disease - Scientific American