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Talk of the Town | Local News – Barre Montpelier Times Argus

Closing leads to reopening

CALAIS The Calais community was having a double celebration this holiday season, after the successful shareholder buyout of the Maple Corner Store.

From here on, it will be known as Maple Corner Community Store, thanks to the support of hundreds of individual donations to raise the $450,000 needed to keep the store open.

After just five months of fundraising, the closing of the buyout was Dec. 17, and there was a party to celebrate it at the Maple Corner Community Center on Saturday.

In between the closing and the party, shareholders, supporters and newly hired staff were busy stripping out some of the fixtures, repainting and resetting the layout of the interior.

Anne Marie Shea, who has worked at the store for 10 years, is the new general manager, and Caity Kaye and Jamie Moorby will be assistant managers, all responsible for the day-to-day operation of the store, which is open seven days a week.

The store reopened Friday and included a performance in The Whammy Bar music venue to celebrate the successful shareholder buyout.

The closing of the store covered the $375,000 asking price, plus inventory, closing costs and attorney fees.

The community drive followed an unsuccessful two-year effort to sell the store by owners Artie and Nancy Toulis, who bought it in 2007.

Since then, it has remained a popular pit stop and social center for locals. It is where local children board the school bus, people make a quick stop for coffee and a breakfast sandwich or lunch, and a place to find groceries and a selection of wines. Also it offers a range of home-cooking-style foods, including freshly made pizza and sandwiches and pub grub for the bar.

The Whammy Bar opened in October 2012 as a small, intimate pub and live-music venue in the back of the store.

The store generates income as well from a rural post office on site, and there is a second-floor, two-bedroom apartment with loft space and a large deck overlooking a waterfall and stream.

Artie Toulis penned a heartfelt thank you letter to the community on Front Porch Forum this week.

Our time at the store was amazing!!! Getting to know everyone and being at the center of many community events sustained and uplifted us, Toulis wrote. We were here for births, deaths, good times, bad times and everything in between.

Toulis, an accomplished guitarist and serious music lover, said he and his wife were most proud of The Whammy, which had nurtured the careers of many musicians, including their daughter, Halle.

The bonds we formed with all the amazingly talented musicians will certainly continue, Toulis said.

Toulis said he and his wife would remain in the area and continue to provide sound and lighting technical support services for local music and theater productions, and urged the community to support the store in the future.

What the Maple Corner Community Store group just accomplished was nothing short of miraculous! Toulis added. Their efforts ensured the stores long-term survival, and those of you that bought shares are now part of a great effort that is bigger that the store itself.

BARRE A Barre businessman is again spearheading an effort that will open the Barre Municipal Auditorium for a few hours on five successive Saturdays so that children of all ages can play basketball in one of the Vermonts most storied gymnasiums.

While hell look for sponsors to help share in the cost, Burnie Allen, of Allen Lumber, has locked down the Aud from 11 a.m. to 2 p.m. Saturday, and all four Saturdays (Jan. 4, 11, 18 and 25) next month.

Those interested in using the auditorium gym on any (or all) of those Saturdays should remember to use the rear entrance, bring sneakers and some friends for some free fun.

Smorestice celebration 2.0

MIDDLESEX A second attempt to break the Guinness World Record for the largest smore will be held from 4 to 8 p.m. Saturday at Camp Meade in Middlesex.

The second annual Camp Meade Winter Smorestice Celebration hopes to break the Guinness World Record of 267 pounds for the worlds largest smore. Last years attempt was too late to qualify, but organizers hope to make the record book this year.

The event will include music, dancers and bonfires, and the turtle oven created for the Great Vermont Bread Festival and Red Hen Bakings 30th anniversary earlier this year will be fired up to make pizza and soups. Foam Brewers are creating a specially labeled Smorestice beer.

The cracker portion of the smore will be baked on site by the bakers at Red Hen. The organic marshmallows will be provided by Monarch and Milkweed in Burlington, while Rabble Rousers chocolatiers will provide the essential chocolate for the Middlesex world record smore, which will be approximately 4 feet by 8 feet.

The fire-centric focus of the event goes beyond the giant bonfire. There will be warming barrels of fires for hanging around and a large urn of fire for a similar, more communal, experience.

The Middlesex Volunteer Fire Department will be on hand to hose things down, if needed, and on hand to speak to anyone interested in becoming a volunteer firefighter.

BURLINGTON The 11th annual Vermont Brain Bee (VBB) is looking for student and teacher participants in a statewide neuroscience contest.

Designed to encourage and inspire high school students to get interested and involved in the study of neuroscience, the written, practical and oral contest will include a Brain Bee boot camp Jan. 25, and then the VBB competition itself on Feb. 15, both at the University of Vermont.

The guest speaker at the main event will be UVM chairman of pharmacology Mark Nelson, and his talk will be on the Blood Network in the Brain.

Throughout the school year, students from the UVM and Saint Michaels College collaborate with high schools all over Vermont to teach them some of the foundations of neuroscience. Teachers interested in joining the collaboration are also encouraged to sign up for the contest.

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Talk of the Town | Local News - Barre Montpelier Times Argus

Sex, Lies & Brain Scans by Barbara J Sahakian and Julia Gottwald review thinking out of the box – The Guardian

Many people have endured the noisy, and somewhat claustrophobic experience of a conventional MRI scan. Functional magnetic resonance imaging (fMRI) is very similar, except its scans reveal changes in bloodflow. When used to study the brain, it shows when an area becomes more active due to the increased flow of oxygenated blood. Once the only way scientists could study the brain was in a postmortem. Now fMRI is a key tool in neuroscience, offering an unparalleled view of the brain in action, providing insights into our most basic emotions, motivations and behaviours, as well as conditions such as Parkinsons disease.

This book takes us on a whistle-stop tour through some of the most exciting scientific studies. The science and technology are still evolving but researchers have already used fMRI scans, analysed by a computer, to reconstruct a film clip watched by subjects. It was blurry and not very detailed but still remarkable.

Other experiments include attempts to read dreams, and to detect social biases such as racism and sexism; in one study, researchers achieved a 100% success rate in detecting lies. However they also showed that it was relatively easy to trick the technology: even the most accurate computer model can be fooled.

From what fMRI scans tell us about free will, to how neuromarketing reveals what consumers really think about brands, this is a fascinating guide to neuroimaging and the wonders of one of the most complex structures in the universe: our brain.

Sex, Lies & Brain Scans: How fMRI Reveals What Really Goes on in Our Minds by Barbara J Sahakian and Julia Gottwald is published by Oxford (9.99). To order a copy go to guardianbookshop.com. Free UK p&p over 15.

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Sex, Lies & Brain Scans by Barbara J Sahakian and Julia Gottwald review thinking out of the box - The Guardian

Brain tumor organoids may be key to time-sensitive treatments for glioblastomas – Science Codex

PHILADELPHIA --Lab-grown brain organoids developed from a patient's own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it. A new study in Cell from researchers at Penn Medicine showed how glioblastoma organoids could serve as effective models to rapidly test personalized treatment strategies.

Glioblastoma multiforme (GBM) remains the most difficult of all brain cancers to study and treat, largely because of tumor heterogeneity. Treatment approaches, like surgery, radiation and chemotherapy, along with newer personalized cellular therapies, have proven to slow tumor growth and keep patients disease-free for some periods of time; however, a cure remains elusive.

"While we've made important strides in glioblastoma research, preclinical and clinical challenges persist, keeping us from getting closer to more effective treatments," said senior author Hongjun Song, PhD, Perelman Professor of Neuroscience in the Perelman School of Medicine at the University of Pennsylvania. "One hurdle is the ability to recapitulate the tumor to not only better understand its complex characteristics, but also to determine what therapies post-surgery can fight it in a timelier manner."

Co-senior authors include Guo-li Ming, MD, PhD, Perelman Professor of Neuroscience, and Donald O'Rourke, MD, the John Templeton, Jr., MD Professor in Neurosurgery, and director of the GBM Translational Center of Excellence at Penn's Abramson Cancer Center.

Lab-grown brain organoids -- derived from human pluripotent stem cells or patient tissues and grown to a size no bigger than a pea -- can recapitulate important genetic composition, brain cell type heterogeneity, and architecture, for example. These models are allowing researchers to recreate key features of patients' diseased brains to help paint a clearer picture of their cancer, and allowing them to explore ways to best attack it.

What makes organoids so attractive in GBM is timing and the ability to maintain cell type and genetic heterogeneity. While existing in vitro models have added to researchers' understanding of the biological mechanisms underlying the cancer, they have limitations. Unlike other models, which need more time to exhibit gene expression and other histological features that more closely represent the tumor, brain tumor organoids developed by the research group grow into use much more rapidly. That's important because current treatment regimens are typically initiated one month following surgery, so having a road map sooner is more advantageous.

In the new study, the researchers removed fresh tumor specimens from 52 patients to "grow" corresponding tumor organoids in the lab. The overall success rate for generating glioblastoma organoids (GBOs) was 91.4 percent, with 66.7 percent of tumors expressing the IDH1 mutation, and 75 percent for recurrent tumors, within two weeks. These tumor glioblastoma organoids can also be biobanked and recovered later for analyses.

Genetic, histological, molecular analyses were also performed in 12 patients to establish that these new GBOs had largely retained features from the primary tumor in the patient.

Eight GBO samples were then successfully transplanted into adult mouse brains, which displayed rapid and aggressive infiltration of cancer cells and maintained key mutation expression up to three months later. Importantly, a major hallmark of GBM -- the infiltration of tumor cells into the surrounding brain tissue -- was observed in the mouse models.

To mimic post-surgery treatments, the researchers subjected GBOs to standard-of-care and targeted therapies, including drugs from clinical trials and chimeric antigen receptor T (CAR-T) cell immunotherapy. For each treatment, researchers showed that the organoid responses are different and effectiveness is correlated to their genetic mutations in patient tumors. This model opens the possibility for future clinical trials for personized treatment based on individual patient tumor responses to various different drugs.

Notably, the researchers observed a benefit in the organoids treated with CAR T therapies, which have been used in ongoing clinical trials to target the EGFRvIII mutation, a driver of the disease. In six GBOs, the researchers showed specific effect to patient GBOs with the EGFRvIII mutation with an expansion of CAR T cells and reduction in EGFRvIII expressing cells.

"These results highlight the potential for testing and treating glioblastomas with a personalized approach. The ultimate goal is to work towards a future where we can study a patient's organoid and test which CAR T cell is going to be the best against their tumor, in real time." O'Rourke said. "A shorter-term goal, given the heterogeneity of glioblastomas, is that in vitro testing of various therapeutic options may also help refine patient enrollment in clinical trials, by more accurately defining mutations and selecting the appropriate, available targeted therapies for each."

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Brain tumor organoids may be key to time-sensitive treatments for glioblastomas - Science Codex

Mourinho: Festive schedule against every rule of physiology, biology, biochemistry – The World Game

Spurs were involved in the early kick-off on Boxing Day, rallying from a half-time deficit at home to record a hard-fought 2-1 triumph over Brighton and Hove Albion.

However, the victory came at a cost, with Harry Winks andMoussa Sissoko both picking up yellow cards that mean the duo will be suspended forSunday's (AEDT) game at Norwich City.

Son Heung-min is also banned following his red card against Chelsea, leaving Mourinho with a lack of options -as well aslittle preparation time -for the trip to Carrow Road.

However, before his focus switched to the next game, the Portuguese took aim at the schedule.

"I cannot imagine these boys, not just my boys, but the [Graham] Potter boys, how they can play in 48 hours," Mourinho told the media.

"If you go to control the distances they run, the intensity, the breaks, if you are going to control that and if we are going to tell anyone who understands physiology, it is a crime that they are going to play football again on the 28th.

"It is against every rule of physiology, biology, biochemistry, every rule. But that is the way it is, even with three guys suspended.

"I think from the three, two of them are unfair, Sonny unfair, Winks unfair, I can only say Sissoko had a reason for the fifth yellow card. We have to go."

Tanguy Ndombele may provide a solution to the absences inmidfield after the Frenchman was not involved against Brighton.

Mourinho clarified that while the record signing from Lyon was not injured, the player had raised concerns over his physical condition prior to the game.

"I cannot say he is injured, in five minutes we start a training session and you can go to the stands and watch it, he is going to be training normally so I cannot say he is injured," Mourinho said.

"I can say that yesterday he told me he was not feeling in condition to play the game. Not based on injuries, based on fears of previous injuries that he has had since the beginning of the season.

"Feeling not ready to start the game, but I cannot say he is injured, I can say he is not in condition to start the game, which is different."

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Mourinho: Festive schedule against every rule of physiology, biology, biochemistry - The World Game

Why Exercise is the Real Miracle Drug – Discover Magazine

Exercise is good for you. Thats hardly news: People who exercise tend to have longer, healthier lives. But until recently, researchers have tallied its benefits only in narrow slices: Exercise lowers your cholesterol and blood pressure; it keeps you from getting fat. Now its becoming clear that those known slices dont add up to the full pie.

When people totaled up those effects, they only account for about half the benefit, says Michael Joyner, an exercise physiologist at the Mayo Clinic in Rochester, Minnesota. So whats contributing to the biomedical dark matter?"

To solve that mystery, researchers are now digging deeper into the mechanisms that underlie the benefits of physical activity. They are finding that exercise is both powerful and wide-reaching, affecting not just muscles and the cardiovascular system, but almost every part of the body, from the immune system to the brain to the energy systems within individual cells. And as scientists understand more precisely which levers exercise pulls to improve our health, clinicians are on the verge of being able to change their practice. The goal is to think of exercise as a medicine a therapy that they can prescribe in specific doses for specific needs.

Its like your own personal regenerative medicine, says Joyner.

Scientists have long known that some of the benefits of exercise are a simple matter of plumbing. Exercise makes blood vessels bigger and keeps them functioning smoothly, which makes them less likely to plug up and cause a heart attack or stroke. There have been hints that this may also mean more blood flow to the brain, which could help prevent cognitive decline. For example, studies have linked exercise to a reduced risk of Alzheimers.

Now researchers are making a more explicit connection between exercise and brain health. They are discovering that the full benefit of exercise comes not from mere physical movement but from actual physical fitness, the bodys cardiovascular health. A long-term study of Norwegian military recruits, for example, found that theiraerobic fitness at age 18 was highly predictive of their risk of dementiain old age. And Swedish women who were highly fit in middle age had aneight times lower risk of dementiaover the next 44 years than women of only moderate fitness, researchers reported in 2018 inNeurology.

Another recent study, led by K. Sreekumaran Nair, an endocrinologist at the Mayo Clinic, found that after just 12 weeks of a high-intensity exercise regimen, participants brains showedincreased glucose uptake and higher metabolic activity, particularly in regions that usually show decline in Alzheimers disease.High-intensity exercise was found to have a similar effecton the parts of the brain most affected by Parkinsons disease, in research led by Marcas Bamman, an exercise physiologist at the University of Alabama at Birmingham.

Exercise doesnt just build bigger blood vessels; it also builds bigger muscles. That benefits health in a number of ways, from minimizing the risk of diabetes to enhancing the bodys immune response to ills such as cancer.

Muscle is the largest consumer of all the glucose that floods into the bloodstream after a meal. More muscle means quicker removal of this glucose surge, says Bamman and therefore, less exposure to the harm caused by elevated blood sugar, a serious health issue for people prone to diabetes.

Just getting the minimum recommended amount of exercise (7.5 metabolic equivalent (MET) hours per week) reduces mortality risk by 20 percent compared with no exercise at all. Exercising a little more than that minimum continues to reduce the risk, but such benefits taper off after about three times the recommended minimum. (MET is the ratio of a person's working metabolic rate relative to their resting metabolic rate, 1 MET is the rate of energy expenditure while at rest, walking at 3 to 4 miles-per-hour is considered to require 4 METs.)

The muscle-building aspects of exercise also help reverse a key change associated with aging: a decline in the function of mitochondria, our cells energy generators. This decline, often seen in sedentary individuals, can leave the mitochondria unable to completely burn the cellular fuel and that can lead cells to generate more oxidants, the oxygen-rich, reactive molecules that damage proteins and DNA.

Muscles are chock-full of mitochondria and exercise can help avoid this oxidative damage. Nairs studies show that aerobic exercise, alone or in combination with strength training,improves peoples mitochondrial function, reduces the production of oxidants and forestalls oxidative damage. High-intensity aerobic exercise alsoencourages mitochondria to produce more of the proteinsthey use to burn fuel.

Muscle has another important role: Its abundant proteins serve as reservoirs of amino acids for the rest of the body. Usually, when other organ systems need amino acids, says Bamman, those are drawn from muscle. Thats especially important when someone is sick because the immune system needs lots of amino acids to make antibodies that fight infection.

Read more:

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The biggest benefit from building muscle, though, may come from the signaling molecules it pumps into the blood. Bente Klarlund Pedersen, an exercise physiologist at the University of Copenhagen, identified the most-studied of these signaling molecules back in 2000, and later coined a term for them: myokines. Since then, she and other researchers have found hundreds more, many of which are activated by exercise. These molecules, which are released in response to muscular exertion, help regulate muscle growth, nutrient metabolism, inflammation and a host of other processes. I think for most people its difficult to understand why muscle work can influence my liver or be good for my brain or bones, she says. Myokines serve as the link between muscle activity and these other organs.

One of the most important myokines in this crosstalk is interleukin-6. Released in response to muscular exertion, IL-6 has several effects, includingsuppressing hungerandenhancing the immune systems response to cancer. Another signaling molecule, cathepsin B, triggersbeneficial changes in the brain, including the production of new brain cells. Other signaling molecules can help moderate depression.

Exercise, of course, also helps keep you thinner and especially, it forestalls the accumulation of abdominal fat, a particularly harmful sort. One reason abdominal fat is so bad for you is its partnership with inflammation. If we take out visceral fat and study it in the lab, we see that visceral fat is more inflamed than subcutaneous fat, says Pedersen. This inflammation will spill over into the blood, causing chronic systemic inflammation.

Chronic inflammation, Pedersen suggests in the 2019Annual Review of Physiology, may be the underlying reasonwhy inactivity contributes to so many different diseases. We know that being physically inactive increases the risk of approximately 35 different diseases or disorders, she says. And if you have one of these diseases lets say you have type 2 diabetes you have increased risk of others, like cancer or heart disease. If we tie it all together, one feature of all these diseases is physical inactivity, and the other is chronic inflammation.

Even a few weeks of inactivity can cause fat to accumulate in the abdomen, which spurs chronic inflammation throughout the body. This inflammation contributes to a range of ailments, including type 2 diabetes, cardiovascular disease and Alzheimers disease.

About a decade ago, Pedersen conducted an experiment in which she had healthy young men reduce their daily step count from about 10,000 steps per day to just 1,500. Within two weeks, the men showed a7 percent increase in abdominal fat mass. Along with this change, the men showed hints of reduced insulin sensitivity, a change also seen in type 2 diabetes.

Interleukin-6 appears to be at the heart of exercises effect on visceral fat and inflammation. In a recent experiment, Pedersen and her colleagues put 27 potbellied volunteers on a 12-week exercise-bike program, while 26 other volunteers remained inactive. Half the participants in each group also received a drug that blocks the action of IL-6. At the end of the 12 weeks, the exercisers had lost abdominal fat, as expected butonly if they had not received the IL-6 blocker. (Oddly, IL-6 is generally thought of as a pro-inflammatory molecule, because it is more abundant in obese people with systemic inflammation. But Pedersen has some evidence that in these people, elevated IL-6 is an effect, not a cause, of the inflammation.)

As researchers tease out more of the details about how physical activity benefits health, the moment is fast approaching when exercise becomes not merely a good thing to do, but a medicine in its own right, just like pharmaceutical drugs. Several studies already point in this direction. For example, more than half of 64 adults with type 2 diabetes were able tostop taking medication to lower their blood sugarwithin a year of beginning a regular exercise program, Pedersen and her team found. And a survey of more than 300 randomized controlled trials found thatexercise was just as effective as drugsfor people at risk of heart disease and diabetes, and was more effective than drugs for rehab after a stroke.

But if exercise is to truly become a medicine like any other, clinicians will need to learn how much to prescribe to maximize its benefits. Just saying be physically active is like telling people eat better it doesnt tell us what we should be doing, says Kirk Erickson, an exercise psychologist at the University of Pittsburgh. But developing more precise dosing recommendations is difficult, because there are so many ways to exercise, which vary in duration, intensity, frequency and kind. (Tailoring to individual disease risks telling one person to doX because theyre at risk of diabetes, and another person to doY because of a family history of dementia is an even more distant goal.)

Researchers are still working out what matters in this complex arena. Exercises that involve more muscle groups generate more IL-6, so full-body exercises like running have a greater anti-inflammatory effect than exercises that target just a few muscle groups, says Pedersen. And the benefits go away within a couple of days, suggesting that exercising frequently is important. If its been 48 hours since you exercised, its time to do it again, says Jill Barnes, an exercise physiologist at the University of WisconsinMadison.

A series of upcoming randomized trials may soon bring more certainty to the dosing question. One of the largest, which Bamman is involved with at the University of Alabama, will have nearly 2,000 volunteers undertaking either 12 weeks of endurance exercise, 12 weeks of weight training or no exercise program. Researchers will measure gene activity, molecular signaling and other changes within the body, which could allow them topin down exactly how these two modes of exercise differin effect. Because the study is so large, researchers should also be able to explore why some people respond more strongly than others to the same dose of exercise.

Another large study that Bamman is participating in, funded by the US Department of Defense, aims to comparegenes activated by moderate exercise to those activated by high-intensity exercisein young, healthy volunteers.

Erickson is trying to parse the specifics with a study that will assess theeffect of exercise volume on brain aging. Researchers will measure inflammation, signaling molecules, body composition and other markers, as well as mental acuity, on more than 600 volunteers ages 65 to 80, both before and after a year of exercise. Some of the volunteers will do 150 minutes per week of supervised moderate exercise, others will do 225 minutes per week, while a third group will do light stretching instead.

Of course, even after the results of these and other forthcoming trials are in, the right amount of exercise for a particular person is likely to depend on their individual circumstances. For someone with diabetes who wants to improve blood-sugar control, even 10 minutes is probably great, says Barnes. But for cardiovascular risk or brain health, that may be different.

Bamman agrees. Theres not a single organ system in the body that isnt affected by exercise, he says. Part of the reason the effect of exercise is so consistent and so robust is that there isnt a single molecular pathway its going to be a combination of all these things. So at the end of all these trials, were going to look back and list off not just one or two mechanisms, but a number of them. Its going to be a complicated answer in the end.

If exercise is good medicine, how do researchers in the field dose themselves?Knowableasked the experts about their own exercise regimens.

K. Sreekumaran Nair, Mayo Clinic:For many of my diabetic patients, I recommend three days per week of high-intensity aerobic exercise and two days of weight training, with the other two days to do walking. But myself, I do 5 days of high-intensity interval training. And every day I do one kind of resistance exercise: leg press, chest press

Michael Joyner, Mayo Clinic:Forty-five to 60 minutes every morning. I do alternate days biking with intervals one day and a strength circuit the next day. I ride my bike to work 100 to 150 days per year. We just moved near a small lake and I have been swimming across it and back (about a mile) three to four times per week. That will stop when it gets cold.

Jill Barnes, University of WisconsinMadison:Six days a week, movement in the morning (usually yoga, 10 to 60 minutes). Five days a week, cardio in the evening (cycling, running, paddling, hiking at a moderate pace) 25 to 80 minutes. One to two days a week, strength training in the evening, 10 to 25 minutes."

Marcas Bamman, University of Alabama, Birmingham:I exercise five days per week, and sometimes six. I exercise at a pretty high intensity and combine resistance and endurance training.

Kirk Erickson, University of Pittsburgh:I run regularly, usually four to five times per week, and also do some strength training exercises. I have also played squash for many years.

10.1146/knowable-121919-1

Bob Holmesis a science writer based in Edmonton, Canada.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews.

Read more:
Why Exercise is the Real Miracle Drug - Discover Magazine

What 2019 Was Like for the First Space Nation – Asgardia Space News

It has been an extremely productive year for Asgardia: major accomplishments were made, new goals set, amazing historic event held. Lets take a look at these 10 great steps the First Space Nation took this year, and see the progress weve made so far

Asgardias First Space Science and Investment Congress Oct 14, 19 - Oct 16, 19 (Oph 07, 03 - Oph 09, 03)

The historic FirstAsgardia Space Science and Investment Congress, held in Darmstadt, Germany, gathered scientists, experts, entrepreneurs, students, investors, media representatives and Asgardians to pave the road to living in space! This fascinating event lasted for 3 days, new promising approaches were suggested, problems associated with long term space missions were discussed in unprecedented detail, economical aspects of space travel were studied. Among the speakers were such extraordinary and well-known aerospace industry specialists as Laurence Young, the Apollo Program Professor in MITs Department of Aeronautics and Astronautics,Satoshi Iwase, Professor of the Department of Physiology at Aichi Medical University (Japan), Jeffrey Manber, CEO of Nanoracks,Frank De Winne, Belgian astronaut, Dr. Mark Shelhamer, Former Chief Scientist of the NASA Human Research Program. The congress was a unique event that brought people from all around the world united by one dream together under the umbrella of Asgardia.

Asgardia Presented in Davos Jan 22, 19 (Aquarius 22, 03)

The population of Asgardia as of today exceeds 1 million Earthlings who reside in more than 200 countries all over the globe. Asgardias motto is: One humanity one unity.

Asgardias main mission is the birth of the first human in space, said the special representative of the Head of Nation of AsgardiaRuslan Ashurbeyli. Leon Shpilsky, the Minister of Finance of Asgardia,delivered conceptual model of Asgardian economic system proposed by theHead of Nation.Asgardia is the only Nation focused on networking cooperation and digital economy. It is a digital society connecting people who either already currently, or plan to in the near future, conduct their economic affairs both in the digital and non-digital formats, saidMinister of Finance. Shpilskypresented the mainEconomic Principles of the First Space Nation to international officials and businessmen at Caspian Week.

Second Asgardian Executives Congress starts in Tallinn Nov 24, 19 (Sag 20, 03)

The Congress held in Tallinn, Estonia brought together membersof theAsgardian Parliament, the Ministers, the Mayors and, of course, theHead of Nation. Dr Igor Ashurbeylilaid out a plan for expanding Asgardias representative offices and emphasized the importance of attracting new residents to the space nation: 'We can achieve a population of 1.5 million Asgardians by 2020, saidDr Ashurbeyli. Reaching out to new Asgardians and evolving the lawmaking process these challenges were the most important ones that Executives face. During the Congress everyone was deeply involved in the process of legislation, Asgardiaseconomy was another main topic of discussion.

Head of Nation addressed the government and parliamentary officials at the First Asgardia Executive Congress Apr 12, 2019 (Tau 18, 03)

Head of Nationgave an inspiring speech about Asgardias main goals and the achievements of the First Space Nation at the Executive Congress in Vienna, Austria. Head of Nation announced Asgardias key mission the birth of the first human in space, once accomplished, it will allow humanity to become independent of its home planet. Spaceflight is very similar to seafaring, and its time for mankind to prepare to leave its native harbor and venture out to unknown shores the Head of Nation said in his inspiring speech. Dr Ashurbeyli then discussed Asgardia's population, political structure and economic development. The concluding phase of Asgardias political construction must be full UN membership, saidHead of Nation. Asgardia has already become a reality, said Dr Ashurbeyliin conclusion I dont know what awaits Asgardia down the road, but today, by the very fact that we are all here earthlings from 10 different countries, MPs from 42 countries, and Asgardians from 200 countries we are living proof that Asgardia is a reality. I thank all of you for believing in Asgardia. Now, lets make sure that the spark of hope for mankinds continued existence and procreation in the endless Universe burns bright, and never goes out.

Asgardian Government gets assembled Apr 12, 19 (Tau 18, 03)

With the fully assembled government, all the Ministers and Committee Chairswere confirmed at theAsgardia Executives' Congress.Using the ceremonial Constitution, the Head of Nationconducted the swear in ceremony. Dr. Ashurbeyliread the oath together with the Parliament Chair Lembit Opik, Prime Minister Ana Mercedes Diaz, and Supreme Justice Yun Zhao: We, the highest officials of Asgardia, solemnly swear to be loyal to the Space Kingdom of Asgardia, to perfectly comply with its Constitution and laws. To be devoted to our high mission, to direct all our activities for the benefit of the State and the people of Asgardia. To perform our duties responsibly, with due dedication and professionalism.' 'Yes, I swear, Parliamentary Committee Chairs and Government Ministers repeated three times.

National Award received by three laureates Oct 15, 19 (Oph 08, 03)

Three people were honored with theGold Medal for Achievements in Space Exploration for the first time in history: Dr. Mark Belakovsky from Russia, Dr. Michael Gillonfrom Belgium and Dr. Robert Thirsk fromCanada. The laureates received the awards from the hands of Head of Nation on the second day of the Asgardias First Space Science and Investment Congress in Darmstadt, Germany. TheGold Medal of Asgardia is a national award established to recognize extraordinary contributions to the advancement of human civilization into space.

Fourth Sitting of the Supreme Space Council of Asgardia Held in Moscow Nov 28, 19 (Sag 24, 03)

The sitting of the Supreme Space Council was attended by the Head of Nation Igor Ashurbeyli, the Chairman of Parliament Lembit pik, the Prime Minister Ana Mercedes Diaz, the Supreme Justice of Asgardia Yun Zhaoand Executive Secretary of the sitting Dmitry Gulko. That day, a new concept of building Asgardia'spopulation was revealed by Dr. Ashurbeyli, and next, the methodological guidelines for this work will be developed. The work of eachMinisterand Chairman of the Parliamentary Committee was evaluated, further steps in establishment of a judicial system were taken: a unanimous decision to create a working group in order to prepare a draft law on the judicial system ofAsgardiawas made during the meeting. The draft will be presented for the first reading during the February Sitting of Parliament. Relations with other countries were brought up by the Head of Nation. Dr Ashurbeyliproposed to start immediately implementing actions to establish bilateral relations with earthly countries.

Asgardia Lectorium opened in Moscow Aug 6, 19 (Vir 22, 03)

Asgardian Mayor Aksana Prutskovalaunched a new educational initiative in Moscow, a lectorium,with the help and support of Asgardias local team. We will talk about technology, design, creativity everything that takes the human mind beyond the ordinary. Our goal is to unite enthusiastic people from all walks of life, help them feel theyre kindred spirits, part of something big, and allow them to exchange ideas, because genius is born where differences meet. Frankly, this is what Asgardia was built for, said the lectorium organizer.

Mayors Met in Tallinn to Discuss Plans for Asgardias Community Nov 25, 19 (Sag 21, 03)

During the Second Asgardian Executives' Congress,9 Mayors from around the globe met their Government for the first time in person. Later, Mayors held their own official meeting communicating with the ones who couldnt attend via conference call. Mayors are the active Asgardians who build up the Space Nation, making it extremely important they have proper communication, so they can share their experiences in the development of local communities.

Exhibit In Cosmic Unity: Time and Space held in Moscow Jul 16, 19 (Vir 1, 03)

Moscow hosted an exhibit In Cosmic Unity: Time and Space dedicated to the creation of Asgardia and the Inauguration anniversary of the Head of Nation.

The exhibition brought together talented sculptors, bold artists, Asgardians, cosmonauts and film directors. Many guests joined Asgardia, and have since then supported the mission of the First Space Nation.

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What 2019 Was Like for the First Space Nation - Asgardia Space News

The Amazing Monkey Island In Puerto Rico Where Humans Are The Ones In Cages – Forbes

Rhesus macaque monkeys walks on Cayo Santiago

I was in a small boat cruising past a tiny island one mile off the eastern coast of Puerto Rico when I first noticed the islands odd inhabitants. The island of Cayo Santiago is completely inhabited and controlled by over 2,000 rhesus macaque monkeys. I was excited to have the opportunity of visiting the exclusive land of monkeys, but tourists are not allowed to set foot on the island. Humans are not allowed to stay on the island and researchers are limited to their time on the island, so my experience was from a distance.

On this secluded Monkey Island, the Rhesus macaques colony first began when hundreds of them were delivered in 1938 for research projects, and it became the ultimate destination for primatologists. With the support of Columbia University and the School of Tropical Medicine of the University of Puerto Rico, psychologist Dr. Clearance Carpenter created a 38-acre island as the site for the project.

Monkey Island pre-hurricane damage

The monkeys were captured from 12 different districts of India, crated and transported by boat passing through NY up to San Juan. The goal was to establish a disease-free breeding colony of monkeys in order to provide animals for research on tropical diseases.

CayoSantiagobecame well known for its research on population management practices and its extensive genetic and demographic databases. Still, everything changed in an instant in 2017 when Hurricane Maria destroyed the island with most of its vegetation lost.

Rhesus Macaque monkeys on the island

I spoke at length with Angelina Ruiz-Lambides, Scientific Director Cayo Santiago Biological Field StationCaribbean Primate Research Center, about the after-effects of the hurricane and how life on the island ultimately flourished.

We observed post-hurricane how social networks were altered in the wake of an environmental disaster, in a collaboration project with Roehampton University, UPENN, Univ. of Exeter, and the UPR, she said. Primates are expected to socially adjust in response to dynamic environments. We found proximity networks were significantly altered post-hurricane, suggesting individuals became more tolerant in the more challenging post-hurricane days given the lack of water and food. I personally observed similar behavior amongst the people of PR. You could observe people being more tolerant; a good example of this was how well traffic was managed even though there was no power.

Rhesus Macaque monkeys on the island

Post-hurricane, the CSFS scientific staff continues their commitment servicing the local community after the devastation caused by the hurricane. We have received the assistance of AmeriCorps volunteers, and other volunteers affiliated to Project Monkey Island (a group made up of scientist and other great people from the USA) that have joined us in rebuilding homes in the community and also removing tons of debris from Cayo Santiago as well as in our reforestation efforts. she continued. After the devastation caused by Hurricane, the lack of vegetation represents a challenge of food availability and shade from the intense sun for the colony of rhesus macaques.

Rhesus Macaque monkeys on the island post hurricane

Following the hurricane, the research had to be put on hold, and it took almost two years to finally be able to capture the younger individuals to collect a blood sample and to tattoo for identification. The researchers also collect behavior during the year, to find out more about the physiology of those individuals studying aging or stress; they need to collect these blood samples for genotyping or hormone analysis.

It is still a mystery of how the majority of the monkeys survived the hurricane. Angelina thinks they simply huddle in little family groups against the base of the trees, or they move around the hills according to how the wind or the rain hits. It's very impressive that they survive these two hundred mile force winds. Before the hurricane, we had around sixteen hundred. And now we have over two thousand monkeys on the island.

Monkey Island in Puerto Rico

They have completed several collaborations with the University of Puerto Rico and the University of Pennsylvania and Exeter, where they saw how social networks were altered right in the wake of an environmental disaster such as Hurricane Maria. Research with the California State University, Long Beach and Richmond Universitydiscovered that female reduced-price fertility was like a buffer strategy during hurricane years and that females might skip having a baby the following year in order to focus on their health before getting pregnant.

And I wondered what daily life was like for researchers on the island. Every day we take a boat, from 7am to 3 p.m. where we spend the day collecting behavioral data and collecting poop samples, she explains. It's dangerous. The monkeys are aggressive. They are habituated, but they're still wild animals, so we have very minimal interaction with them and kind of like pretend that we're ghosts. We don't interact. Themonkeys also carry herpes B, a version of the virus that can be deadly to humans upon contact.

Cages keep the monkeys out and the humans in

And forget communal dining with the monkeys, humans are the ones in cages on this island. Years ago, we would not have any cages to eat our food since the monkeys would be aggressive and steal our food. Now we have cages where we can take a break and not be bothered by the monkeys and to try and minimize the disruption, she says.

A new law was recently passed by the government, and people will no longer be able to trespass on the island. Visitors can only be approved through the University. For now its all about research and less about selfies.

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The Amazing Monkey Island In Puerto Rico Where Humans Are The Ones In Cages - Forbes

The Odyssey it in the family – INDONEWYORK

Carmen retired at 62 years old. She is a professor of Physiology and ceased to teach at the Faculty of Medicine of the Autonomous University of Madrid and Cdiz after four decades. Five years ago he enrolled in Classical Philology. Went from the living organs to the dead languages. After learning classical Greek found in the original text of the Odyssey parts that had disappeared or had been given attention in the translations. What has come are the adventures of Odysseus and however, women have a very important role that has been lost in the way. Called attention because the society mycenaean was very misogynistic and this is a book that today we would call feminist, says Carmen Estrada, that with this premise forced his son to illustrate the journey of all those characters.

And to the son, the cartoonist Miguel Brieva (Seville, 45 years) had no other choice but to stop for a few months the lashes, the anti-capitalists of their bullets, and devote himself to the mythology. A mother you can't say no, he says ironically. We have not made an Odyssey to Hollywood. The rest happens in the culture mycenaean, pre-classical, and we have observed that aesthetic, in which everything seems more amateurish, like grass. We have done archaeology to be very faithful to that reality, says Brieva.

In The Odyssey: Illustrated (Malpaso) there are no winks to the present, and the characters don't even speak. The beings of Brieva are convicted of a verb, but here we do not say or mu. I don't consider myself a good illustrator, I have other urgent matters that count. Although the image I work a lot, for me it is subordinate to the message. But here it is upside down and the message is the book. That has been my odyssey. It is something similar to what was done by Robert Crumb with The Genesis, says the cartoonist.

that, To me, humanity is the humility with which Odysseus faces hardship

Miguel Brieva, illustrator

despite that, he sees in Odysseus a reflection of the migrants, who travel and play life for years, they live about incredible and they have the absence of rancor. That, to me, is the humanity, the humility with which Odysseus faces hardship. And that he was protected by some gods, he adds.

Brieva coincides with his mother in that the story's original shows how Odysseus is surrounded by women who excel in intelligence on the men. Athena, Circe, Calypso, Penelope, Euriclea, Nausica... The guys are more than screwing up and angering the gods, he says. For the authors of this epic poem illustrated by focusing on women, the work varies and the protagonist also. In their transit through multiple identities, it is women who help Odysseus to perform the mutations. They have to carry their narrative. Then, who is the protagonist? They are essential, says Estrada.

They have to carry the narrative of Odysseus. Then, who is the protagonist? They are essential

Carmen Estrada, philologist

Until Polyphemus is another. It was not just that giant, monstrous and merciless. The interpreter of the classic work sees it and describes it as a very methodical and orderly, with their routines of giant, which dealt with a lot of affection for his sheep. It is one more proof of the original aspects that had been lost over the centuries, and the reinterpretations. That is why Estrada is convinced of the findings of the traits that had gone unnoticed until now, as the reading of gender that has made the classic among the classics. It is a book that has infinite readings, because it is a reflection of those who read it. Now we can do this reading, because we women have been overlooked for many years. Margaret Atwood wrote an epic of Penelope in the first person. In fact, why do we think that has not been written by a woman the Odyssey? I see it as a possibility, responds Estrada.

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The Odyssey it in the family - INDONEWYORK

BUZZ-U.S. STOCKS ON THE MOVE-NewLink Genetics, Verisign, WESCO International, Microbot Medical – Nasdaq

Eikon search string for individual stock moves: STXBZ

The Day Ahead newsletter: http://tmsnrt.rs/2ggOmBi

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U.S. stock index futures hovered near record-highs on Tuesday, buoyed by optimism about the global economy in the wake of improving trade relations between Washington and Beijing. .N

At 8:16 ET, Dow e-minis 1YMc1 were up 0.09% at 28,575. S&P 500 e-minis ESc1 were up 0.05% at 3,229, while Nasdaq 100 e-minis NQc1 were up 0.05% at 8,730.75. The top three NYSE percentage gainers premarket .PRPG.NQ: ** WESCO International Inc , up 8.0% ** Ocwen Financial Corp , up 4.9% ** TETRA Technologies Inc , up 3.9% The top three NYSE percentage losers premarket .PRPL.NQ: ** NGL Energy Partners LP , down 6% ** Frontline Ltd , down 3.5% ** Ooma Inc , down 3.4% The top two Nasdaq percentage gainers premarket .PRPG.O: ** Microbot Medical Inc , up 21.7% ** Proteostasis Therapeutics Inc , up 15.4% The top three Nasdaq percentage losers premarket .PRPL.O: ** Verisign Inc , down 22% ** Ferroglobe Plc , down 17.4% ** Cpi Card Group Inc , down 10.8% ** Advanced Micro Devices AMD.O: up 0.9% premarket BUZZ- Rises for fourth day as RBC sets Street high price target ** Cel-Sci Corp CVM.A: down 5.2% premarket BUZZ- Drops on discounted stock offering ** NewLink Genetics NLNK.O: up 12.3% premarket BUZZ- Rises on licensing deal for its cancer treatment

(Compiled by Trisha Roy in Bengaluru)

((Trisha.Roy@thomsonreuters.com; within U.S. +1 646 223 8780, outside U.S. +91 80 6749 7786;))

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

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BUZZ-U.S. STOCKS ON THE MOVE-NewLink Genetics, Verisign, WESCO International, Microbot Medical - Nasdaq

Anatomy of a Suicide: Stress and the Human Condition – James Moore

I remember saying to my therapist that I must be doing something wrong. Life felt so hard. Why was I struggling so much? I would have given anything to fit in with the favored crowd the commendable, worthwhile, socially entitled, who wear success like a loose garment, bedecked with grace and ease. Why couldnt I just follow my dreams and the latest instructions from Oprah, Dr. Phil or Martha Stewart Living and pull prosperity casually, effortlessly out of my trendy, warm, chunky, soft-stretch, cable-knit beanie? (Like they presumably did.)

Wasnt that the point of popular media, celebrity talk shows, and mainstream self-help?

For everyone in the know, this kind of flow is regarded as manifest destiny. For the rest of us, there are coping skills. Either way, respectable people do not lose their shit, not for a moment and certainly not for years or decades at a time.

A hard lesson for me to get in my suicidal journey was that my body was having none of this. I kept pointing to the beautiful tri-fold brochure that the culture said my life was supposed to look like. It was such a great message:

Bountiful living is free for the taking. Personalities, careers, and relationships can all look fabulous. All they need is a bit of shaping, conditioning, and polishing. My existence can be as readily manicured as cuticles and nails.

But my body kept pointing out my real experience. Incontrovertibly, the two didnt match.

I did everything I could to get myself on board. I tried drugs, self-talk, journaling, yoga, mindfulness, all kinds of therapy and a zillion self-help strategies. Try as I might, my body refused to cooperate. The more I tried to convince her what was good for us, the more she dug in her heels. I would use the most esteemed positive self-talk. She would fart, burp, and break out in impetigo.

So I tried to up my ante. I prodded her, cajoled, manipulated, offered or withheld praise and treats, resorted to shame, blame and outright cruelty. Nothing worked.

In fact, it backfired. At some point, my body just got too upset. She started doing her own thing, whenever, wherever and however she felt like. No matter that my career, housing or finances would be ruined. Some imperceptible line had been crossed, and she slipped out of my reach. On those rare occasions that I could get a rise out of her, she refused to focus or calm down. Try as I might, I couldnt bring her back.

That was my state three years ago, when I thought I would toss in the towel. It wasnt my first visit to this realm, but it was probably the scariest and darkest.

Weve come a long way since then, my body and me. Its taken considerable study, reflection, and experience to give my body some credit. I now believe my body was a lot wiser than I suspected. I wish I had listened and started taking what she was trying to tell me seriously a lot sooner. I might not have had to sink so deep or stoop so low in so many areas of my life if only I had.

My body doesnt speak English. She speaks feelings. When shes upset with me or my life, the language she speaks is stress.

1. Stress is a natural response to threat and overwhelm

The human body has a surprisingly similar set of responses to a broad array of stressors. (Sapolsky, 2004, p. 8.) The same basic templates appear to be hard-wired in all of us a sort of instinctive pre-programming for when life gets too threatening or overwhelming. Thus, when certain thresholds are reached, corresponding survival defenses (mediated by the stress response) predictably emerge.

2. The stress response tells me what I care about

Like most modern humans, its not just physical survival that Im concerned with. I want to survive socially, emotionally, and economically too (among other things). As a result, I dont just activate the stress response when Im being chased by a tiger. The range of concerns is much broader than that. According to Robert Sapolsky (2004), professor of biology and neurology at Stanford University and world-renowned stress researcher:

We activate the stress-response in anticipation of challenges, and typically those challenges are the purely psychological and social tumult that would make no sense to a zebra. (p. 9)

Stress is how my body tells me something matters. It may be tangible or intangible, physical or psychological, material or spiritual, cognitive or behavioral, personal or social, passive or active Any or all of this (and more) can activate the stress response and its corresponding mental and physical impacts. Again heres Sapolsky (2004) describing the stress response:

There is now an extraordinary amount of physiological, biochemical, and molecular information available as to how all sorts of intangibles in our lives can affect very real bodily events. These intangibles can include emotional turmoil, psychological characteristics, our position in society, and how our society treats people of that position. And they can influence medical issues such as whether cholesterol gums up our blood vessels or is safely cleared from the circulation, whether our fat cells stop listening to insulin and plunge us into diabetes, whether neurons in our brain will survive five minutes without oxygen during a cardiac arrest. (p. 5)

Thus, the stress response is every bit as complex and multi-dimensional as I am.

4. Stress is about protecting my future

Something does not have to be happening now to stress me out. As a survival strategy, the stress response is always trying to get a head start on trouble. Thus, my stress response thoughtfully alerts me whenever Im afraidsomethingcouldhappen:

[T]he stress-response can be mobilized not only in response to physical or psychological insults, but also in expectation of them. It is this generality of the stress-response that is the most surprisinga physiological system activated not only by all sorts of physical disasters but by just thinking about them as well. (p. 7)

In other words, I dont just stress about things that threaten my present survival. Continual uncertainty about future survival will do me in too.

Thats the normal human body.

Im not saying anything new or radical here. Im just stating the facts of life about the body I was born with. No chemical imbalance, pre-existing trauma, or genetic defects required. Just my human body, as engineered by evolution, operated according to the instructions encoded in normal human DNA.

In my own experience, wanting to die is a logical consequence of mounting physical and mental distress. The more overwhelmed I become, the less I am able to function and, as a result, the physical, emotional, and practical fallout progressively rises. Ultimately, this reaches intolerable, seemingly hopeless levels that lead me to want to end my life. Heres a diagram from the first piece in this series (The Sisyphus Cycle: How everyday stress leads to suicide), if you want a quick review:

Thats all good and well, but no sane person is going to give up something as precious as their life for something trivial. So obviously a stress model of suicide requires a lot of stress. Where does all that stress come from?

The question was particularly troubling for me, given that for most of my life Ive had it easy. My father was a pediatrician. My mother was a kindergarten teacher and stay-at-home mom. They both wanted kids and loved us dearly. They were hard-working, responsible, active in schools and community service. They attended all my athletic events, exposed me to culture, planned interesting and enriching family vacations. They paid for my college education and a significant chunk of graduate school. Time and again, they sacrificed their own needs to make sure my brother, sister and I had every advantage they could afford. In short, they were amazing role models as well as devoted, conscientious parents.

So why was I breaking down?

In my first couple decades of mental health treatment (late teens, twenties, early thirties), the providers I saw honed in on my family of origin. We spent countless sessions examining every possible way they could have been insensitive, overly sensitive, under-protective, over-protective. Obviously something had to have gone wrong.

During that time, I did a lot of blaming and shaming of anyone who affected my path. In retrospect, it is painful to see how desperate I was to find some excuse for the mess I had become and was making of my life.

Finally, in my late thirties, I gave in and accepted the mental illness diagnosis. Over the next decade, there were various and sundry incarnations, twelve DSM labels in all, for which I tried over 20 different drugs and many flavors of therapy.

Sadly, but not uncommonly, my downward progression was continual. By my late forties, I was ready to give myself up for lost and accept my chronic fate. I left practice as a therapist and owned my status as a peer. My decline continued from there, quite possibly because I finally had permission to act as lousy as I felt.

Somewhere along the way, however, the nickel started to drop. Peer status allowed me to have a lot of honest conversations (with both myself and others) that frankly I never could have had as a therapist. As a practicing professional, there simply was too much at stake on both sides of the couch (mandatory reporting, keeping up appearances, boundaries).

In the peer community, however, I discovered two important things:

Since most of us were getting little relief from the mental health system, I started wondering what happened to bodies in chronic stress. This led me to study the stress response, where I started making connections. Eventually, with a bit of popular science reading on stress physiology and some rudimentary self-observation, I began to make sense of my own mind and body, and how I was responding in the modern world.

The long and the short of it is that I no longer see myself as mentally ill. I also no longer need to jump out of my skin from chronic discomfort, regret for my past and fear for my future. What I think Im up against is the human condition. The stress response is part of that. Like all things human, the stress response is mixed. In the right circumstances, it is a life-saving, life-enriching gift. In the wrong ones, it is a curse that can make my life a living hell.

My hope here is to shed light on how the latter happens and why, for me, it took a suicidal turn. In doing do, Ill focus on two purely human common denominators:

Ill explain how, for me, these two entirely normal factors can interact and feed on each other. Ill share how I believe this turned my essentially normal human body into an instrument of torture to the point where it seemed like ending my life was the only reasonable way out. No mental illness, extreme childhood trauma, bad chemistry or genes required. Just the garden variety human condition that all of us are up against every single day.

Before I go further here, however, I need to deal with a sensitive issue. In the process of writing this piece, I became acutely aware of an unpleasant social fact. In reality, all stress isnt equal. Moreover, some stressors arent normal. Painfully, there are social misuses and abuses of power that create life-threatening levels of trauma for far too many of us in the modern world. The next piece in this series will address these unnatural stressors. Discussed there will be the devastating kinds of social dynamics where someone puts their thumb on the scale in massively predatory ways. It is there, perhaps above all else, that absent active intervention by others of conscience, the rational instinct to suicide becomes abundantly, tragically clear.

But that is then, and this is now. So up next:

In my own experience, there is a lot going on, outside my control, that has to be reckoned with physically and mentally in this human endeavor of life on earth. Evolution itself tells me how precious, vulnerable, and precarious my existence on this planet actually is.

To be born in the first place, nature ordained a nine-month, specially-designed, comfort-padded, form-fitted, super-insulated, dynamically-adjusted, around-the-clock vigilantly-guarded period of incubation. Highly recommended, after leaving this refuge, are several more years of intensive care, nurturing, and schooling. Most commonly, this is offered by experienced intimates (called parents) who have already survived to maturity in my relevant environment.

In modern society, such mentoring is not only physical but also economic, emotional, intellectual, social, cultural, and spiritual. A logical implication of the need for such extensive care is that the human maturation process is complicated and labor-intensive for all concerned. A lot can and does go wrong.

But even if it all goes remarkably well, from the moment I am born there are a couple of grim realities:

This is the human condition.

Here is just a sampling of the kind of thing Im talking about:

In addition to the inherent conditions of existence, there is a boatload of expected stuff that no one else can do for me. Included in this are developmental mile markers, established for the culture I live in, as indicators of good and responsible living. Achieving these mile markers invariably requires some level of mastery on my part both internal and environmental.

No matter how much others want to help me, in the end, it is up to me. I have to figure out, on my own, how to get the mind and body I was born with to comport with some accepted variant of the cultural ideal. If I fall short, then I fail to meet the cultural standard for full membership and perhaps even for full humanity. Even if I can hide my shortcomings, that doesnt protect me from the pain. Everyone knows the standards, including me. I still know Im failing even if you dont.

On some level, Im aware that my most basic survival needs cant really be protected. Disaster happens, both environmentally and socially. Its the stuff that newspapers and bestsellers are full of. This awareness is hanging over me all the time. Even if I dont experience this kind of tragedy directly, social learning ensures that I register what happens to others when tragedy strikes them.

Im not saying everything is bad out there. But its clearly not all good either. Below are just a few examples of stuff thats on my radar. Some of it I live with daily, other things affect people I know and love. Still other things I watch from a comfortable distance grateful, for now, that it isnt happening to anyone I know

On top of all this, here comes the real kicker: No one actually has the answers.

Yeah, there are a lot of theories and philosophies. There is a lot of practical, social, and spiritual wisdom. Clearly, some approaches hold more promise than others. At the same time, on a concrete, measurable, scientific level, no one really knows. As a whole, for the human race, we still have more questions than answers about the stuff that really matters.

When I think about it, thats quite a list. And this is just the normal stress that everyone has to deal with. No childhood trauma, natural disasters, freak accidents, or untimely misfortunes.

The point is, theres a lot to figure out. I am born into a world with few if any certainties. There is a lot going on mentally, physically, socially, environmentally, existentially that I have to reckon with. There are a lot of ways to get lost or trip up.

As a result, the probability is high that at some point I am going to get stuck. Somehow, some way, I am going to meet my match in life. A particular challenge is going to lodge itself squarely into the heart of my vulnerability and stop me cold. I will fail to achieve something important to me, or I will lose something or someone I feel like I cant live without. The more I care, the more vulnerable I am. But, in the end, its more likely a matter of when, not if.

To appreciate what happens next, it helps a lot to understand the Defense Cascade. I wrote about this extensively in a piece called Traumatic Immobility: Depression as a Stress Response. For the purposes of todays discussion, the essentials are this:

The Defense Cascade is a survival framework that evolutionary researchers are exploring as an explanation for extreme states that many people experience. It outlines the progression of defensive strategies that human beings in distress tend to draw on as levels of threat and overwhelm increase (Shauer & Elbert, 2010). Most people have heard about these defenses and think of them in terms of Fight/ Flight/Freeze. But trauma researchers are now developing a more sophisticated model, called the Defense Cascade (graphic below).

To explain how these above defenses map onto suicide, Im going to make my own chart:

There are three basic levels:

A simple way to understand how stress affects me is like a car. Like putting my foot on the Gas Pedal, stress triggers the sympathetic system (Action Central), which responds by rapidly delivering power to the movement centers of my body (muscles, arms, legs). This allows me to amp up quickly, cover a lot of territory, and exert control over my environment in ways that I think will serve my interests.

This is what happens in Level 1. Essentially, Im surprised, afraid, or excited, and the Gas turns on. After a brief pause to assess options (Attend/ Freeze), the active defenses (Fight/ Flight) kick into gear. At manageable levels of stress, the active defenses are largely adaptive. I notice an issue, examine my options, dodge what I can, face what I have to. Eventually, I escape or win.

HA!! Problem solved. Another notch in the belt.

But what if Im in over my head? Ive run my fastest, fought my hardest, but still cant escape. Im out of ideas, energy, and options. Nothing I know how to do is working. I have no idea how I got here and not a clue how to fix it.

If the active defenses fail me, I proceed to Level 2 (Fright). This is a transitional stage that can go either way.

In these desperate circumstances, my body resorts to a desperate ploy. It slams on the Brake while the Gas is still blaring. This drops my heart rate and blood pressure to the floor and freezes me in my tracks. This Fright response buys me time when Ive already played my best hand, and I dont know what to do next.

The cost to me mentally and physically, however, is enormous. Because Im scared, the Gas Pedal keeps revving my muscles full bore. But because of the Brake, I feel totally stuck. No matter how much I want to, I cant get myself going. Every little movement takes tremendous effort.

The effect is torturous. I literally want to jump out of my skin. But Im trapped in discomfort, fully aware, unable to movewith nothing to do but watch myself burn myself out working against myself.

However counter-productive this seems, it serves an important survival function. The Brake helps me stay put for safety purposes, even when Im raring to go. To pick up on my car analogy, the Brake is what keeps me from blowing through a stoplight that I urgently wish wasnt red.

If I were a rabbit in the wild, Fright might save my life. Its basically the play-dead response that convinces the fox to put me down and go get a drink of water before making a meal of me. The moment the fox is out of sight, the Brake lifts. I Gas it out of there full bore back to my hole.

If I live in a socially responsive, community-oriented world, Fright has major advantages too. Instead of running around wreaking havoc in a terrified, agitated state, Fright basically holds me harmless when Im out of my league. My people find me, notice something is wrong, go to get help. They care about me enough to listen to what is wrong. Its hard to communicate at first and comes out pretty jumbled. But they stay with me and eventually we make sense of the threat together. We all learn something as a community about scary stuff we could be up against. Then everyone puts their heads together. We have the best of our collective knowledge at our disposal. We all learn from this and from each other. This raises everyones understanding and awareness and helps me to find a way out too.

In the process, we all get the lovely hormonal benefits of the Tend and Befriend response. Dopamine boosts our motivation and sense of purpose as we work together toward a shared goal. Oxytocin builds our sense of connection and belonging. It strengthens the bonds between us as we walk each other to safety.

Sadly, these days, that is probably not what happens. More likely, I am siloed off to treatment, where I am given antidepressant drugs and a class on coping skillsand then sent back to fight the same old battle I was losing before.

If that happens, theres a good chance I get worse instead of better. That only stands to reason since my real problem (troubling real-life circumstances/ stress) is not being addressed. Plus, energy and resources are being siphoned off to deal with a new problem (mental illness) that I dont actually have.

This explains why for me, all too often, seeking mental health treatment is counterproductive. I come away with fewer resources, not more, to deal with the real-life issues that I went (or was sent) to get professional help with. Tragically, if Im already at Level 2 when this happens, I dont have any energy or resources to spare. The added weight of treatment pulls me under instead of pulling me out.

So I proceed to Level 3.

At Level 3 (Flag/Faint), its really clear Im going to lose. Im out of energy and options. Theres nothing left to do but give up. In Flag, Im still aware enough to make a conscious surrender. Its like sitting in my car with the engine running, waiting for the traffic cop to decide my fate. Faint is the literal loss of consciousness. Either I ran out of Gas or someone switched off the ignition.

The lesson from Flag and Faint is that the stress response is tremendously powerful. At extreme levels of stress, people can literally lose consciousness because their brains cant get enough energy to function.

Chronic stress adds insult to injury. The experience, for me, is like a giant sucking sound. It actually feels like my life energy is hemorrhaging as if theres a hole in my being that is being extracted by some nefarious cosmic force.

It took me a long time to realize how close to true this actually is. Stress puts me in a continual high idle and makes it hard to turn that off. From a survival standpoint, theres a good reason for this. If Im in the wild or at war with the Huns, I dont want to let down my guard until I know the danger has passed.

The problem with the Gas Pedal system, however, is that it is only optimal for life-and-death physical challenges that can be expected to be over in about 30 to 60 minutes. After that, my body starts to break down (Sapolsky, 2004, pp. 83-86). You can begin to imagine the toll this takes when a major life problem has no fast or clear resolution.

To really drive this point home, I need to paint the picture in full relief. My Gas Pedal system basically runs on borrowed energy. Like an evil banker, it withdraws massive amounts of energy from the shared pool that benefits my whole body and selectively diverts it to a privileged few. Effectively, it shuts down appetite and digestion, detoxification, immune functioning, and my basic capacity to rest, repair, and replenish myself. It revs up my muscles, putting them on continual hair-trigger alert, making me edgy, tense, and constitutionally incapable of feeling comfortable in my own skin. It rivets my attention on the stuff thats scaring me, rendering me unable to focus on anything else. It leaves the part of my brain (pre-frontal cortex) that is capable of rational, creative, collaborative thinking totally under-resourced. That puts me at the mercy of habitual patterns (like addiction) and impulsive reactions (like hiding, running, or fighting). The game it plays thanks to the effects of hormones like adrenalin is all about power and control. Zero-sum, all-none. Winners, losers. My neck or yours.

Its the perfect storm, really. With higher-order thinking almost totally offline, Im pushed relentlessly for resolution. Somewhere deep inside me, the message is unmistakably clear:

Something is urgently wrong. Someone or something is going to go down. Quite possibly it will be me. Go, go, go, go.

This raises a really important question. If digestion is off (among other things), how does the Gas Pedal system keep going for years on end? Where does the energy come from?

Basically, two places:

In other words, the Gas Pedal system is a cannibal. The reason I feel like Im being stalked and preyed upon is because I am.

The Gas Pedal system is sucking the life out of me in order to fuel itself.

It is literally eating me alive from the inside out.

As you might imagine, the physical, mental, and moral depletion that results from trying to operate this way long-term can make it all but impossible to function. I miss things, lose time, or sleep 18 hours at a stretch. I start to boil water, forget about it, come back to a pot in flames. It is nearly impossible to concentrate or track reality, so I basically give up trying. There are months on end of just sitting around, praying that God will fix or kill me.

If nothing changes, nothing changes. Absent active, effective intervention targeted to reversing stress, I tend to get stuck here. Under the influence of the Gas Pedal system, my physical and mental functioning progressively deteriorate. Bodily maintenance, repairs, and higher-order thinking stay mostly offline. As time goes on, mistakes are made, opportunities are missed, and resources diminish accordingly.

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Anatomy of a Suicide: Stress and the Human Condition - James Moore