All posts by medical

Emergency shelter is not prison, but there are overlapping human rights concerns – Generocity

Shelter is not prison technically speaking. Yet as I wrote in a previous article, the traditional power structure in emergency shelter closely resembles the power structure in prison.

Individuals residing in these institutions are expected to be obedient, docile, and submissive to staff at all times and in all circumstances. Each institution is also similarly defined by the experience of social rejection, sexual frustration, loss of autonomy, material scarcity, chronic stress, disturbed sleep, and emasculation.

Meanwhile, the prevailing social dynamic in male prisons what sociologists call the convict code is nearly identical to the prevailing social dynamic amongst homeless men the code of the streets.Both are behavioral and cultural norms premised on hyper-masculinity, exploitation of weakness, dominance, and violence.

They are two sides of the same coin.

There is also significant overlap between prison and shelter populations with people experiencing homelessness significantly more likely than the general population to have a criminal record, and nearly 20% of city shelter users entering shelter directly after incarceration according to one study.

This overlap means elements of prison culture regularly find their way into emergency shelters. In fact, in my experience, it is not uncommon to hear shelter guests reflexively and matter-of-factly refer to each other as inmates, refer to staff as guards, refer to the shelter itself as the prison, or refer to the curfew as lock up. When enough of our guests have this kind of prison mentality, we reach a tipping point and the shelter culture virtually becomes a prison culture. Yet even if we dont, it remains the case that for many men residing in shelter in Philadelphia, shelter and prison arent all that different.

In that sense, we can say that shelter and prison are experientially alike, but categorically distinct. After all, there is an explicit and meaningful difference between me saying I work for Bethesda Projects Church Shelter Program as opposed to Bethesda Projects Church Prison Program.

This helps explain why, for example, the United Nations has separate international standards for emergency shelters and for prisons namely, because shelter is not prison. Simply experiencing homelessness having no home or housing is not a crime, just as being a refugee, internally displaced person, or stateless person is not a crime. Nor is the act of residing in a homeless shelter a legal form of punishment in the way that being sentenced to prison is.

Because shelter is not prison, we should reasonably expect that a person residing in shelter experiences more liberty, rights, and privileges than a person residing in prison. This is another way of saying we should reasonably expect shelters to meet and exceed the minimum standards for prisons.

So lets take a closer look at whether or not they do.

The United Nations Standard Minimum Rules for the Treatment of Prisoners were first adopted in 1955 and then revised in 2015, at which point they were renamed the Nelson Mandela Rules (in honor of the former President of South Africa). In total, the United Nations lists 122 rules, although the term rules can be misleading. They are meant to describe general principles of practice for prison operation, rather than mandating a specific prison model.

The rules concern matters that range from personal hygiene and exercise to filing systems and instruments of restraint. Together, they affirm that incarceration does not mean anything goes. When a person is incarcerated, their change in social status does not diminish or negate their humanity. In prison as in shelter people retain their human rights.

Unfortunately, when we look closely at the Nelson Mandela Rules, it appears that the experience of residing in shelter in Philadelphia fails to meet at least three of these baseline standards.

First, Rule 5 of the Nelson Mandela Rules states: The prison regime should seek to minimize any differences between prison life and life at liberty that tend to lessen the responsibility of the prisoners or the respect due to their dignity as human beings. When emergency shelters institute arbitrary rules that confine, monitor, and control the lives of shelter guests, their property, their activities, and their movements, we are not respecting the liberty due to them as human beings.

Instead, we are incarcerating them on our terms and incarceration on our terms is still incarceration. Even if our approach to incarceration is less restrictive than prison, we should be asking ourselves whether it is more restrictive than life outside both prison and shelter. If it is, then we are in violation of Rule 5 and depriving people of their liberty when they have not been convicted of a crime.

Relatedly, in a previous article I described how the United Nations High Commissioner for Refugees Emergency Handbook articulates a standard of self-determination and empowerment for people residing in shelter. This standard reappears in the Nelson Mandela Rules, specifically in Rule 40, which states: No prisoner shall be employed, in the service of the prison, in any disciplinary capacity. This rule shall not, however, impede the proper functioning of systems based on self-government.

This rule serves as an indirect affirmation that self-determination, empowerment, and self-governance are appropriate in prisons. As I see it, if the worlds leading human rights organization has legitimized their use in prisons, then surely we can consider them legitimate in emergency shelters.

The standards articulated in Rules 5 and 40 actually intertwine. For example, the notion of life at liberty means you have freedom of movement and freedom from arbitrary detention, while self-governance means you get to participate in deciding the rules that you have to live by and which may impact your liberty. Taken together, they imply that shelter staff should remove all curfews and restrictions on movement (i.e. Once you enter the shelter, you are not permitted to leave until the next morning) unless the guests themselves decide otherwise.

In that sense, compliance with Rules 5 and 40 in emergency shelters also involves democratizing management procedures. Typically, staff members claim a monopoly over establishing curfews, budgeting, managing cleaning supplies, organizing laundry schedules, resolving disputes, etc. However, these are also things that shelter guests will do when they exit shelter into housing, and things that many of them are capable of doing now. As it turns out, according to the Nelson Mandela Rules, it is reasonable to say that they also have a right to do these things now.

The third area where it can be said emergency shelters fail to meet the United Nations standards for prisons involves disciplinary standards. Rule 39 of the Nelson Mandela Rules states that: Before imposing disciplinary sanctions, prison administrations shall consider whether and how a prisoners mental illness or developmental disability may have contributed to his or her conduct and the commission of the offence or act underlying the disciplinary charge. Prison administrations shall not sanction any conduct of a prisoner that is considered to be the direct result of his or her mental illness or intellectual disability. Although the word sanction can mean both penalize and permit, in the context of disciplinary sanctions (as it is used here) it means penalize.

In my experience, I have encountered no clear or explicit restrictions on my ability as a shelter staff member to sanction or discipline a shelter guest for behavior that is a direct result of his mental illness or intellectual disability. On the contrary, the expectation has always seemed to be that I will sanction or discipline any shelter guest for any behavior that is threatening, violent, or which otherwise seriously disrupts the shelter community regardless of what prompted the behavior.

In Philadelphia, given the high percentage of people experiencing homelessness who also live with serious mental illness or intellectual/developmental disabilities, the suggestion that we not discipline problematic behavior resulting from them almost seems to suggest an anything goes attitude.

But thats not what the United Nations is saying.

Rule 39 specifically prohibits sanctioning and disciplining certain kinds of behavior but it does not prohibit responding to it, resolving it, or transforming it. Nor does it prohibit restoring safety, trust, dignity, and community after harm or wrongdoing has occurred. In that sense, the Nelson Mandela Rules are not prohibiting justice. They are, however, prohibiting punitive responses to incidents where a mental health diagnosis or intellectual disability is a key variable.

What Philadelphia homeless services can learn from Rule 39 is that non-punitive, restorative justice practices in shelter settings arent just innovative theyre actually the standard. With that in mind, I encourage emergency shelters to begin reformulating their disciplinary protocols to align with restorative justice practices, as weve begun to do in Bethesda Projects Church Shelter Program.

This kind of transformation may not be easy, but it is necessary because shelter is not prison, nor should it be. If we take that distinction seriously, and I certainly hope that we do, then emergency shelters have an obligation to meet and exceed the minimum human rights standards for prisons.

See original here:
Emergency shelter is not prison, but there are overlapping human rights concerns - Generocity

God Squad: Readers respond about giving to the panhandlers – Newsday

I got lots of comments on my column supporting giving to beggars. I wrote the column expecting that I might produce only one or two notes of agreement, but my heart was lifted by the number of softhearted readers who, like me, give to beggars. Of course, there were a few like this one, from W:

In this day and age your answer was absolutely wrong! Enabling begging, alcohol and drug addicts exacerbates the problem!

Many of these people will not accept help from shelters because their addiction is more important to them! By funding their habit, you are making their circumstances worse.

Encourage people to give generously to shelters and organizations that assist the homeless. This is the Christian thing to do!

I respect that point of view, but I disagree with it. In our broken world, it is almost always the case that we cannot change the big things but can have an impact on little things. As Mother Teresa wrote, "God does not call us to do great things. God calls us to do small things with great love." Amen.

The following notes lifted my heart and convinced me that many people are doing small things with great love.

From K: I read your piece on giving to the homeless. So many people have the same questions in our church. So now we have prepared snack bags that have a short blessing attached. When we see homeless people, we hand them a bag and they are always appreciative. My husband and I have always felt that any money we give no matter where is given in God's name and no longer belongs to us and we don't question how it's used.

From J in New York:I have worked in NYC for the past 38 years. I, too, had a dilemma about giving to the less fortunate. I finally realized that I was in a better place than those who asked for a handout. I then made sure that I always had a couple of singles in my pocket and would give to anyone who asked. Or I would put a couple of granola bars in my pocket and distribute them. If there was someone I saw on a regular basis, I would ask if there was anything I could get them. Usually they would ask for personal hygiene items. If I ever saw tube socks for sale, I would also give them out. The bottom line is that God, for whatever I did, has granted me and my family a very comfortable life. Thank you very much for this article;if only more people felt this way and [did] not make assumptions, we would be a better society.

From N:I believe that most homeless people fall into two categories people with mental health problems and those who fell into homelessness because of circumstances. I fell into the latter category and without the help of friends and family, I would have been living on the street. I agree with you saying not to judge others, assuming they are druggies or scammers. Most of these people are down on their luck and, as you said, who in their right mind would want to beg just to survive? It must be humiliating. I thank God every day for being here with me through the good and especially the bad things in life.

M from Gainesville, Florida:I thank you for the reply you wrote regarding giving money to beggars. I would like to add one thing: I sometimes see someone who is asking for handouts accompanied by a dog. Rather than just give money, I prefer picking up a small package of dog food to give them. They always accept it with a smile. One even said that he was sure that his friend would share it with him!

And my favorite response that came from B:I read your column often and often feel lifted up and given water by a greater soul than mine. I have traveled a lot and far these past six-plus decades. I have seen the beggars, the homeless, the needy, the liars, the helpless, the drug addicts, the lost, the hopeless, the lonely, the predators, the starving, the thieves, the spiritually bereft, the seekers, the musicians, the broken. This I avow to you:That every one of those descriptions of human behavior I have been and done! I give to anyone broken. I give that lousy dollar. Not to feel better about me. THEY are me! Greater souls than mine have pointed out that divinity is in the shadows of human action. My last gasp is a quote from you: "Great changes come from small change." I thank you with fondness and am looking forward.

SEND QUESTIONS AND COMMENTS to The God Squad at godsquadquestion@aol.com or Rabbi Marc Gellman, Temple Beth Torah, 35 Bagatelle Rd., Melville, NY 11747.

See more here:
God Squad: Readers respond about giving to the panhandlers - Newsday

Severity of autism symptoms varies greatly among identical twins – National Institutes of Health

Media Advisory

Friday, December 27, 2019

Findings from NIH-funded study could inform treatment strategies.

Identical twins with autism spectrum disorder (ASD) often experience large differences in symptom severity even though they share the same DNA, according to an analysis funded by the National Institutes of Health. The findings suggest that identifying the causes of this variability may inform the treatment of ASD-related symptoms. The study was conducted by John Constantino, M.D., of Washington University School of Medicine in St. Louis, and colleagues. Funding was provided by NIHs Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The study appears in Behavior Genetics.

ASD is a developmental disorder that affects how a person behaves, interacts with others and learns. Previous studies have found that when one identical twin has ASD, chances are extremely likely that the other twin has it, too.

The authors analyzed data from three previous studies comprising a total of 366 identical twin pairs with and without ASD. The severity of autism traits and symptoms in the twins was measured by a clinicians assessment or by parents ratings on a standardized questionnaire. Some cases were diagnosed by both methods. The researchers determined a 96% chance that if one twin has ASD, the other has it, too. However, symptom scores varied greatly between twins diagnosed with ASD. The researchers estimated that genetic factors contributed to only 9% of the cause of trait variation among these twins. In contrast, among pairs of identical twins without ASD, the scores for traits were very similar.

The study authors do not know the reasons for differences in symptom severity, but they rule out genetic and most environmental causes because the twins share the same DNA and were raised in the same environment. Additional studies are needed to determine the cause.

Alice Kau, Ph.D., NICHD Intellectual and Developmental Disabilities Branch, is available for comment.

Castelbaum, L. On the nature of monozygotic twin concordance for autistic trait severity: A quantitative analysis. Behavior Genetics.2019.

About theEunice Kennedy ShriverNational Institute of Child Health and Human Development (NICHD): NICHD conducts and supports research in the United States andthroughout the world on fetal, infant and child development; maternal, child and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visitNICHDs website.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

###

Read more:
Severity of autism symptoms varies greatly among identical twins - National Institutes of Health

Resolving for a healthy 2020? Talking to your family is a great way to start – Mountain Grove News Journal

(BPT) - An estimated 130 million Americans make resolutions for 2020 with more than half of them focused on health. However, most resolutions are broken by February.

Marjan Champine, a board-certified and licensed genetic counselor at Ancestry, the global leader in family history and consumer genomics, shares tips for thinking about your health in 2020:

1. Small choices matter for a healthier you in the New Year.

Day in and day out, the small choices we make can end up making a big difference in how we feel and our overall health. The journey to better health can be as simple as to:

2. Talking to your family can unlock valuable insights into your health.

Understanding your familys health history and screening for common genetic conditions can provide information about some potential health risks. Armed with this information, there are powerful choices and actions you can take to improve your health, and your familys health, now and in the future.

You dont need to be alone in trying to make sense out of all of this. Genetic counselors can help you connect the dots of your family health history and the results of genetic health screening tests. Services like those offered by Ancestry, which recently launched AncestryHealth, can also empower you with genetic insights to put you on the path to a better, healthier you. When you and your health care provider know more about your risks for certain conditions, thats the start on the path toward better health.

3. Your genes dont need to be your destiny.

While genetics plays an important role in our health, the daily choices we make about our activity, sleep, nutrition and how we handle stress can also play a role in our quest for better health.

Because families share genetics as well as other health-related risk factors such as diet, lifestyle and environment family history is again important in this regard. Most people understand the health benefits of a good diet and exercise. But whats often overlooked is the importance of knowing your familys health history. By sharing your family health history in addition to any genetic health test results with your health care provider, you can work together to create a personalized plan of action to treat, manage and, in some cases, even prevent certain diseases.

4. Specific, achievable, actionable and enjoyable.

I am always looking for fun ways to improve my health. As part of that goal, my resolution this year is to spend more quality time with my family, share stories about our history and keep a record of our health history all in one place using AncestryHealths family health history tool.

If you havent made a New Years health resolution yet, think of a goal thats specific, actionable and achievable. Also think of goals that can be achieved in ways you enjoy.

5. The time is now.

Now is the perfect time to jump in and begin tackling your 2020 New Years health resolutions. Your family health history and genetic screening results could unlock important information that will allow you to manage your health.

The more you know about your genetic risk factors, including your family health history, the more you can take proactive steps, in collaboration with your health care provider. Taking this information and sharing it with your health care provider is important so that, together, you can create a personalized plan of action for a healthier 2020.

Marjan Champine is a board-certified and licensed genetic counselor at Ancestry with a passion for family, health and helping others.

See original here:
Resolving for a healthy 2020? Talking to your family is a great way to start - Mountain Grove News Journal

2 Things That Will Propel Seattle Genetics Stock Even Higher in 2020 – Motley Fool

Seattle Genetics' (NASDAQ:SGEN) shares soaredas much as 6% after the U.S. Food and Drug Administration approved its bladder cancer drug this month, and the stock now is heading for a total gain of more than 86% for 2019. The biotech company, which has a pipeline of candidate treatments for various cancers, now has a new product on the market and is optimistic about an investigational treatment that recently earned the FDA's "breakthrough" label.

IMAGE SOURCE: GETTY IMAGES.

Let's have a closer look at the two elements that could lift the shares in 2020, even after this year's spectacular performance.

Seattle Genetics announced the accelerated approvalof Padcev (generic name: enfortumab vedotin-ejfv) on Dec. 18 for the treatment of patients with locally advanced or metastatic urothelial cancer. It's the most common kind of bladdercancer, and develops in the cells lining the inside of the bladder. The approval is specifically for adult patients who have previously been treated with platinum-based chemotherapy and a PD-1 or PD-L1 inhibitor. PD-1 and PD-L1 are proteins in the body, and in some cases, they help cancer cells hide from an immune system attack. Inhibitors prevent this from happening. As for Padcev, it targetsthe Nectin-4 protein and leads to the destruction of cancer cells.

A key point in this approval news is that Padcev is the only FDA-approveddrug for this patient set, meaning that it will be an obvious choice and welcome option for many. Seattle Genetics has said about 2,000 to 4,000 new patients per year may be candidates for Padcev, but CEO Clay Siegall said it's difficult to forecast an exact patient population. However, according to GrandView Research, the global urothelial cancer drug market will reach $3.6 billion by 2023, with a compound annual growth rate of 23%. In the U.S., about80,000 new cases of bladder cancer are diagnosed per year, and about 90% of cases are of the urothelial type. So a foothold in this market is a definite growth opportunity for Seattle Genetics.

Seattle Genetics aims to submit tucatinib, its investigational treatment for HER2-positive breast cancer, to the FDA in the first quarter. That's a positive development, but even better is the fact that the FDA already grantedtucatinib breakthrough status based on data from a phase 3 clinical trial. Tucatinib was administered along with Roche'sHerceptin and another drug, and riskof death declined by 34%. The study also showed a 46% decline in risk of disease progression. HER2stands for a protein -- human epidermal growth factor receptor 2. In HER2-positive breast cancer, high levels of this protein within tumors lead to the spread of cancer cells. Tucatinib inhibits enzymes that activate this type of protein.

Breakthrough status is meant to expedite review and approval for treatments that address life-threatening illnesses, so if all goes well, Seattle Genetics could have a third drug on the market sooner rather than later. (The company also sells Adcetrisfor Hodgkin lymphoma.) The market for HER2-positive breast cancer is expected to increase by 54% from its 2015 level to $9.89 billion in 2025, according to GlobalData.

Padcev and tucatinib both address conditions where the need for new treatments is obvious. Though Seattle Genetics' earningshistory hasn't been great -- it missed its EPS forecasts in the past two quarters -- its recent product news offers investors reasons for optimism about revenue streams to come. A new drug on the market and high hopes for another approval are catalysts that should help its share price make healthy gains in the new year.

View original post here:
2 Things That Will Propel Seattle Genetics Stock Even Higher in 2020 - Motley Fool

Can Johnson & Johnson Break Out In 2020? – The Motley Fool

Johnson & Johnson(NYSE:JNJ) enjoyed an excellent run from 2010 to 2017, climbing from $63 to $140 before entering a more volatile period over the past two years. Since then, the stock has bounced between $120 and $147, and it sits closer to the top of that range as 2019 comes to an end. Investors who rode that wave have probably felt frustrated with the ups and downs in recent years, and they're hoping the stock will fare better next year.

The branded company's pharmaceutical segment generates 53% of total company revenue and 67% of its operating profit. This portion of the business currently markets dozens of drugs, but Stelara, Remicade, Imbruvica, Zytiga, Invega, and Darzalex are the current best sellers. Potential regulatory changes and competitionthreatenthe segment, and heavy investments in research and development or acquisitions are required to maintain arobust pipelineto replace drugs with expiring patents. Previous top-seller Remicade is experiencing declining sales due to competition, and pipeline products fromAbbVie(NYSE:ABBV) could threaten Johnson & Johnson's immunology group with pending U.S. Food and Drug Administration approvals.

Image Source: Johnson & Johnson

Medical devices are roughly 30% of total sales and 21% of operating profits. This segment is driven by numerous products for orthopedic, surgical, vision, and interventional applications. The acquisition ofAuris Healthcould hasten Johnson & Johson's entry to the robotic surgery market, which it was already targeting through a partnership withAlphabet. This part of the company has struggled to produce sales growth, with the top line declining nearly 4% year-to-date.

Finally, Johnson & Johnson has a consumer health products segment that contributes 17% of revenue and 12% of total company operating profit. These products include well-known brands such as Neutrogena, Tylenol, Aveeno, Motrin, Zyrtec, Benadryl, Visine, Nicorette, Listerine, and Band-Aid. Johnson & Johnson's consumer division will grow through acquiring and developing promising brands moving forward, but this segment is best characterized as a mature, stable, and slow-moving cash flow generator.

Johnson & Johnson's valuation is somewhat complicated by its combination of businesses because no other health stock offers a direct comparison. Conducting a sum-of-parts analysis and backing into weighted average metrics can be illuminating.

Johnson & Johnson trades at 15.6 times forward earnings, which is somewhat lower than the 18.7 weighted average of major drugmakers, consumer staples companies, and medical device makers. This figure is somewhat less exciting when adjusting for the growth outlook, which results in a relatively high 2.6 PEG ratio. The stock trades at a similar discount based on its 19.6 price-to-free-cash-flow, though the above growth rate caveat is relevant here as well. Finally, Johnson & Johnson's 16.4 EV/EBITDA is roughly in-line with the weighted average, indicating that the company's relatively high financial leverage is partially driving the apparent discount.

For income investors, the stock pays a mediocre 2.6% dividend yield. This number is fine, but there are much higher alternatives elsewhere, and Johnson & Johnson has shown dedication to a buyback program that returns value in the form of anti-dilution to stimulate appreciation rather than income.

Analysts are forecasting below 3% growth for 2020, so the investment community does not seem to recognize massive drivers in the future. Expansion into robotic surgery could help bolster growth in the device segment. Tremfya and Spravato are two drugs that could turn into blockbusters to buoy growth in the medium term. However, Johnson & Johnson is simplyso large and diversifiedthat these positive items are likely only sufficient to maintain a moderately positive growth rate.

Major regulatory changes or issues stemming from its role in theopioid crisiscould certainly send shares tumbling, but there's very little about the current growth prospects or valuation metrics to suggest Johnson & Johnson has a substantial room to the upside. It is likely more prudent to buy this stock when it trades closer to the bottom of its recent range.

View post:
Can Johnson & Johnson Break Out In 2020? - The Motley Fool

Infants, Immunity, Infections and Immunization – Duke Today

This is the fourth of several posts written by students at the North Carolina School of Science and Math as part of an elective about science communication with Dean Amy Sheck.

Dr. Giny Foudas research focuses oninfant immune responses to infection and vaccination.

Her curiosity about immunology arose during her fourth year of medical school in Camaroon, when she randomly picked up a book on cancer immunotherapy and was captivated. Until then, she conducted research on malaria and connected it to her interest in pediatrics by studying the effects of the parasitic disease on the placentas of mothers.

As a postdoctoral fellow at Duke, shethen linked pediatrics and immunology to begin examining mother to childtransmission of disease and immunity.

Today she is an M.D. and a Ph.D. and amember of the Duke Human Vaccine Institute. Shes an assistant professor inpediatrics and an assistant research professor in the Department of Molecular Geneticsand Microbiology at Duke University School of Medicine.

Based on the recent finding that children of HIV-positive mothers are more susceptible to inheriting the disease, Fouda believes that it is important to understand how to intervene in passive immunity transmissions in order to limit them. Children and adults recover from diseases differently and uncovering these differences is important for vaccine development.

This area of research is personally important to her, because she learned from her service in health campaigns in Central Africa that it is much easier to prevent disease than to treat.

However, she believes that it is important to recognize that research is a collaborative experience with a team of scientists. Each discovery is not that of an individual, but can be accredited to everyones contribution, especially those whose roles may seem small but are vital to the everyday operations of the lab.

At the Duke Human Vaccine Institute, Fouda enjoys collaborating as a team and contributing her time as a mentor and trainer of young scientists in the next generation.

Outside of the lab, Fouda likes to spend time reading books with her daughter, traveling, decorating and gardening. If there was one factor that improve how science in immunology is conducted, she would stress that preventing disease is significantly cheaper than treating those that become infected by it.

Dr. Fouda has made some remarkable progress in the field of disease treatment with her hard working and optimistic personality, and I know that she will continue to excel in her objectives for years to come.

Post by Vandanaa Jayaprakash NCSSM 2020

Read more:
Infants, Immunity, Infections and Immunization - Duke Today

Companion to Aging: The U.S. should fund CBD research – Foster’s Daily Democrat

This installment is the last of the Marijuana/Hemp CBD series of columns and focuses on the mechanism through which CBD (Cannabidiol Hemp Oil, remember?) works to cure or reduce the magnitude of various ailments.

The ailments that CBD seems to help are arthritis, chronic pain, heart and lung malfunctioning coordinating with the central nervous system. Furthermore, although much more research is needed, it is tentatively concluded that CBD would help reduce autoimmune and inflammatory responses that trigger HIV, cancer and sclerosis.

In terms of dermatological field, CBD is effective in three powerful areas: acne breakouts and redness, preventing excessive oil production and aging over time. Concerning ailments in other animals, such as dogs, cats, horses and birds, we are unaware that their ailments can be reduced or cured by CBD for certain. I have not encountered authoritative literatures on CBD being used to treat animals. However, that is due to my lack of proper literature search. I am convinced there are some solid research literatures available in the field, especially from the research facilities and universities of Israel.

Now we move onto the most important subject of "Why and what does CBD do to cure all that ailments?" Readers, if you are educated through a science class at a college level, you can at least feel that a plant derived chemical would cure or reduce so many wide varieties of ailments as mentioned above can't be real. There has to be some either mistake, misjudgment or worse, a salesman's super hype. Yes, that would be a natural instinct if you had gotten a proper science education in your youth. (Maybe though, you might have slept through it, ha!) So, did I. I said to myself that a chemical extracted from the plant called Hemp, which is available basically everywhere in the world if you look hard, would be so widely effective in treating diseases that seem so remotely connected to each other.

So, I gave myself a mission to dig into this myth. I wanted to find out any credible scientific papers that focus on that question, and that question alone. So, I have gotten some 20 papers of various titles and subjects on CBD. My journey was to find out the very question of why CBD could be so effective for so wide a variety of ailments. My reading these papers started a week ago, and I was nearing the end with no clear conclusion. To read 20 papers in one week is a task I do not want to do again. Finally, I reached the last one, yes, 20th, when my brain got a shot of adrenalin and literally woke up from just a bureaucratic reading to sharply focused excitement. The article title is "Can CBD Really Do All That?" by Moises Velasquez-Manoff, and this paper appeared in New York Time. Due to the limited space and time, I have summarized his description of CBD effect on human body in brief statements.

First, primitive living creatures such as prehistoric fish started to migrate out of the ocean about 460 million years ago. Living on the land gave many advantages to small living creatures than the size-ranked ocean living. One could see farther, and there is less fear of becoming larger foes' lunch. The primitive small living creatures began their journey of evolution to adopt their ability to fit the environment. Today we humans rank as the top dweller of that vast pyramid.

Secondly, in the meanwhile, hemp appeared on the land about 38 million years ago. What hemp brought out into the animal kingdom, including us humans, was a a very effective weapon in immunology. Simply put, hemp produces CBD, which, upon entering human body, produces a material named CB1 Receptor and CB2 Receptors. C 1 ends up in brain, kidney, lungs and liver, while CB2 Receptor ends up in white blood cells of immune system, the gut and the spleen. See Fig 344-1. Without going through a complex and specialized scientific statement, my understanding is that these receptors would then manipulate and guide the human immunological system to better health. As you can see, CB 1 and CB2 combined would cover all the sickness and chronic pain ailments described above. -I would still say that I am amazed that a plant, now called hemp, which showed up on the dry land on the earth 422 million years later than the first primitive animal moved from the ocean to the dry land would know how to fight diseases in the human body and brought forth the very chemical and physiological weapon to do it. Is it just a spectacular coincidence, or God's will and creation?

Nevertheless, we do have this potent weapon called hemp, the most powerful and widely applicable-to-diseases plant on the earth. The plant has been, however, badly mistreated by this nation. In 1937, marijuana was banned nationwide by our country. It does smell of racial prejudice against Mexicans who were entering through the border at that time. I feel that the history may be repeating now. However, I strongly feel that we Americans should positively open up the aggressive research projects on what CBD does for the human health NOW. Israel has been at it, and I am assuming their results would be good. Why are we standing idol and watching the world go by? Hemp produces CBD, which is very widely applicable to many human ailments, and CBD is proven to be positively efficacious with little negative side effects. Let's fund our own research. We have nothing to lose, only much to gain.

This Companion to Aging column appears each week in the Seacoast Sunday features section. You can read earlier installments at http://www.seacoastonline.com. Please send your thoughts about aging to Sasano@umelink.com, Sam Asano, P.O. Box 26, New Castle, NH 03854 or (cell) 781-389-2356 or email Sam at sasano@umelink.com.

Sent from my iPhone

Visit link:
Companion to Aging: The U.S. should fund CBD research - Foster's Daily Democrat

Heartbreaking News, Then Tumor Find Leads to Genetic Testing – Medscape

When Anne Weber became pregnant with her first child at age 28, little did she suspect that, rather than bringing home a bundle of joy, she would have to contend with a cancer diagnosis that would change the course of her life.

At her first ultrasound, not only did she find out that she had miscarried but also that she had a large cyst on one of her ovaries. That cyst turned out to be cancer.

"Because I didn't have a strong family history of cancer, everyone assumed it would be benign," she recalled in an interview with Medscape Medical News. "We were all very surprised when the pathology report came back with ovarian cancer."

Although the incidental finding may have been heartbreaking, it may also have been lifesaving. Because it was caught early, her ovarian cancer was of stage I. She underwent surgery and is now telling her story, 10 years later.

Weber is now a patient advocate at FORCE (Facing Our Risk of Cancer Empowered), a national nonprofit organization dedicated to individuals affected by hereditary breast, ovarian, and related cancers, andpreviously worked for a while at genetic testing company Myriad Genetics.

How Weber developed ovarian cancer at such a young age was initially a mystery. Without a family history and without symptoms or personal risk factors for it, her physician did not suspect a hereditary cancer even though at the time, National Comprehensive Cancer Network (NCCN) guidelines recommended that physicians consider genetic testing for anyone younger than 50 who are found to have ovarian cancer. However, her physician didn't offer genetic testing, or even counsel her about it.

Weber was left with nagging questions. She wanted to know why she'd gotten ovarian cancer and how she could prevent a recurrence. So she started sleuthing around on the Internet.

"When I was diagnosed, I knew nothing about this. Literally, I didn't know what terms to type into the search engine," she said.

When she stumbled onto an online forum that linked her to the NCCN guidelines, the pieces of the puzzle began fitting together.

This was 2009, and she was living in Atlanta at the time. She asked her physician about genetic testing, and her doctor referred her to the only genetic counselor in the city, who was at Emory University. At that time, the wait time for genetic testing was 6 months.

"Six months when you're dealing with something like cancer can be pretty dire," Anne said.

Genetic testing for breast and ovarian cancer has not always been straightforward, and fast-moving research means that genetic testing is becoming more and more complex all the time.

The NCCN may have recently provided a step in the right direction. On December 4, the NCCN released updated clinical practice guidelines on genetic/familial high-risk assessment for breast and ovarian cancer.

The guidelines represent a fairly radical shift from previous recommendations, which focused on BRCA genes, according to Robert Pilarski, MS, LGC, MSW, LSW, a genetics counselor and professor of clinical internal medicine at Ohio State University's Comprehensive Cancer Center. He was also vice chair of the NCCN guidelines panel that updated the guidelines.

The NCCN recommendations remain anchored in strong, unbiased evidence and reflect a conservative approach regarding genes for which there is lack of evidence, he said. But the guidelines also acknowledge a shift toward panel testing and include a table of 17 moderate- and high-penetrance genes that should be considered in addition to BRCA genes. They also provide management recommendations for people who carry these genes.

"Most people now are doing panel testing where the panel involves multiple genes besides BRCA," Pilarski said, "This guideline update is the closest that we've got to a consensus [regarding breast, ovarian, and pancreatic cancer] because it now specifies a set of genes that are reasonable to include in at least a basic panel."

The use of multigene panels is controversial, as previously reported by Medscape Medical News. A study published in early 2019 in the Journal of Clinical Oncology suggested that roughly half of breast cancer patients who carry a pathogenic or likely pathogenic mutation are missed by current genetic testing guidelines. That study used an 80-gene panel, and the authors recommended expanded panel testing for all patients with breast cancer.

Critics shot back, arguing that universal testing is not warranted and that large, multigene panels may create undue anxiety among patients as well as confusion among physicians. Research is in its infancy for many of these genes, and physicians don't know how or even whether to act on results for some of them. That's especially true for variants of unknown significance, which have not been confirmed to increase risk for disease.

Perhaps in response to this controversy, the NCCN guidelines do not recommend universal testing for breast or ovarian cancer. Instead, they provide clinical scenarios in which genetic testing is clinically indicated, may be considered, or has low probability of clinical utility. The NCCN authors hedge their bets by not endorsing for or against multigene panel testing.

"I think we held back from becoming too definitive because there may be times when other genes are appropriate," Pilarski explained. "We didn't want to lock patients out of insurance coverage, and we didn't want to lock ourselves into a set of genes that could change next week with changing evidence."

This "wishy-washiness" over multigene panels creates a problem for Mehmet Copur, MD, FACP, an oncologist who wrote a critical response to the study published earlier this year. He is affiliated with the Morrison Cancer Center in Hastings, Nebraska, and is an adjunct professor at the University of Nebraska Medical Center in Omaha.

"I believe they have tried to please both parties, and they have been too nice," he said. "My personal opinion is that I would go for high-penetrance genes in clinically suspicious settings. I would ignore that disclaimer note and say, 'I'm going to do this 17-gene panel.' "

Going one step further, he suggested the creation of commercially available gene panels based on the NCCN recommendations for these 17 genes.

"There are a wide variety of panels available with different genes on different panels. There is a lack of consensus among experts regarding which genes should be tested in different clinical scenarios. If possible, it would be helpful to create commercially available gene panels based on the updated NCCN recommendations," he said.

In another major change, the guidelines now include pancreatic cancer for the first time. But in contrast to breast and ovarian cancer, the NCCN recommends that all patients with newly diagnosed pancreatic cancer receive genetic testing.

"Approximately 1 in 20 patients with pancreatic cancer will have an inherited susceptibility gene. Most people with pancreatic cancer who carry these mutations do not have a family history of pancreatic cancer, so you can't rely on family history to guide you about who should get genetic testing," Michael Goggins, MD, MBBCH, who was also involved in updating the NCCN guidelines, told Medscape Medical News. Goggins is director of the Pancreatic Cancer Early Detection Laboratory at Johns Hopkins University School of Medicine, Baltimore, Maryland.

Advantages of genetic testing for pancreatic cancer include guidance regarding choice of chemotherapy and the possibility of cascade testing for prevention or earlier detection of pancreatic cancer in family members.

Other additions to the guidelines include new recommendations for genetic testing for individuals with Ashkenazi Jewish ancestry, as well as new or updated recommendations for Li-Fraumeni syndrome and Cowden/PTEN hamartoma tumor syndrome.

The guidelines also offer an expanded section on genetics risk assessment and genetic counseling. Genetic testing has become increasingly complex, and the NCCN emphasizes the importance of genetic counseling throughout the testing process.

It has been 10 years since Anne Weber was diagnosed with ovarian cancer. Because she was diagnosed at a young age (28 years) and her other ovary was unaffected, she opted for surgery to remove only the ovary with the tumor.

After her own Internet research and at her own request, Weber underwent genetic testing. She found out that she is a carrier of the BRCA2 mutation, which carries high risk for breast, ovarian, and pancreatic cancer.

Current recommendations are that people with BRCA2 mutations start breast cancer screening at age 25, so Weber was screened immediately.

Her first breast MRI revealed a mass that was found to be stage I breast cancer. At that point, she chose to have her other ovary removed, as well as both fallopian tubes and both breasts, which significantly reduces her risk for recurrence.

"I'm so incredibly grateful that I found the information. All the guidelines say that I shouldn't even have had my first mammogram at my current age of 39. So there is low likelihood that I would have been diagnosed by now, and it certainly would not have been stage I," she said.

Since her diagnosis, she and her husband have adopted a child.

"Genetic testing isn't right for everyone. People aren't going to make the same decisions I did," she said. "The biggest thing is to understand that being positive doesn't mean that you're going to get cancer. It just allows you to have that circle of care to try to prevent cancer, or at least catch it earlier, when it's more treatable."

NCCN. Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic Version 1.2020. Full text

Follow Medscape on Facebook, Twitter, Instagram, and YouTube.

Link:
Heartbreaking News, Then Tumor Find Leads to Genetic Testing - Medscape

Why The Pentagon Is Warning US Military Not To Use Recreational Genetic Test Kits – Forbes

US Pentagon in Washington DC.

For years, many of us in the genetics community have strongly suggested thatconsumers think long and hard beforeordering recreational genetic test kits for Christmas or any other occasion. But when thePentagon sends a stern warningto its military members, even Santa needs to listen.

Military Mission at dusk

Why would the Pentagon be worried about our military using at-home DNA kits?A memo issued to service membersfrom the Office of the Secretary of Defensestates that recreational genetic kits could give military personnel inaccurate information about their health. These inaccurate results couldhave negative professional consequences,particularly because military members, who are required to report medical problems, are not covered bytheGenetic Information Nondiscrimination Act (GINA),which prohibits genetic discrimination by employers and health insurers.

It is already well known that thesekits should not be usedto answer serious medical questions based on a personal or family history of disease. Anyone with such a history shouldconsult a certified genetic counselorto ensure that an accurate test is ordered and interpreted correctly.The Pentagon concurs, saying they dont advise against genetic testing altogether, but recommend that service members get genetic information from a licensed professional rather than a recreational kit.

But are there other reasons the Pentagon may be warning against recreational genetic test kits? Couldthis genetic information lead to genetic surveillance, tracking, and grave privacy concerns for military personnel and others who use these kits?

China has already demonstratedthat genetic technology and research findings, intended to help people, can instead be used to harm. It is believed that the Chinese government has collected DNA samples from its citizens throughmandatory physicals to create a large databasethats being used to weed out up to one million Uighurs to be sent toconcentration camps. Although U.S. citizens, thankfully, enjoy greater protections than those in China, this example illustrates that our DNA can give insight into ancestry and ethnic origins that can be used for grave harm.

In fact, genetic data can reportedly be usedto determine how gay a person is, and if you are a 23andMe user who shared your data for research, you may have contributed to this study. Could DNA data be used to determine if military personnel may be gay? And if so, could that information beused against them?

And, of course, none of these companies can guarantee that their databases wont be hacked,as has happened in the past. Recently, GEDmatch, the genealogy company used to track down the Golden State Killer, wasacquired by a company created to work with crime labs. Other testing companies have chosen toshare their user data with the FBI.How will all of this consumer data be used, for good or evil? The truth is, we dont know.

finger print with DNA code at background

What we do know is thatundercover military agentscould likely be identified using a small sample of blood or saliva and large DNA databases. This may be true whether or not they personally have undergone recreational genetic testing,since one of their relatives probably has. For our military working undercover, this means that anonymity is likely a thing of the past.

Read the original post:
Why The Pentagon Is Warning US Military Not To Use Recreational Genetic Test Kits - Forbes