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Journal Highlight: The separation and identification of the residual antigenic fragments in soy protein hydrolysates – Ezine – separationsNOW.com

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The separation and identification of the residual antigenic fragments in soy protein hydrolysates

Journal of Food Biochemistry (Article in Press)Guanhao Bu, Ting Huang, Tanghao Li

Abstract: Soybean is one of the major food allergens. In this study, soy protein isolate was hydrolyzed by Neutrase and Flavourzyme. The hydrolysates were separated by ultrafiltration and ionexchange chromatography. The antigenicity of proteins was determined by indirect competitive ELISA. The molecular weight distribution was characterized by SDSPAGE. The amino acid sequence of chromatography fractions was analyzed by LCMS. The results showed that proteins with >50kDa in hydrolysates had the highest antigenicity and were further separated into F1F5 fragments by ionexchange chromatography. Fragment F4, which was the most antigenic, was analyzed by LCMS. The results of mass spectrometry showed that most of the peptides that contained antigen epitopes in chromatography fraction F4 belonged to glycinin subunits. The antigenicity of soy protein was reduced by enzymatic hydrolysis, but glycinin showed resistance to enzymatic hydrolysis.

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Journal Highlight: The separation and identification of the residual antigenic fragments in soy protein hydrolysates - Ezine - separationsNOW.com

AgeX Therapeutics to Collaborate with University of California, Irvine on Neural Stem Cell Research Program for Huntingtons Disease and Other…

Program will utilize AgeXs proprietary PureStem cell derivation and manufacturing technology platform

Goal of developing cellular therapies for Huntingtons disease and potentially Parkinsons, Alzheimers and other neurological conditions

Builds on Universitys research in neural stem cell transplantation for Huntingtons disease, including safety and efficacy animal data that may support an IND submission as early as 2021

AgeX Therapeutics, Inc. ("AgeX"; NYSE American: AGE), a biotechnology company focused on developing therapeutics for human aging and regeneration, announced a research collaboration with the University of California, Irvine (UCI) using AgeXs PureStem technology to derive neural stem cells, with the goal of developing cellular therapies to treat neurological disorders and diseases for which there are no cures. The collaborations initial R&D work, expected to take approximately one year, will be conducted in the UCI laboratory of Leslie Thompson, PhD, Chancellors Professor of Psychiatry & Human Behavior and Neurobiology & Behavior, a leading researcher in the field of Huntingtons disease and other neurological disorders, under a Sponsored Research Agreement handled by the Industry Sponsored Research team at UCI Beall Applied Innovation. The initial focus will be on Huntingtons disease, while other potential targets may include Parkinsons, Alzheimers, and stroke.

The primary goal of the research will be to develop a robust method of deriving neural stem cells from pluripotent stem cells in sufficient quantity and with sufficient purity and identity for use in cell-based therapy. Professor Thompsons laboratory has already accumulated safety and efficacy animal data that may support an IND submission to the FDA as early as 2021 for the commencement of clinical trials to treat Huntingtons disease.

"We look forward to utilizing AgeXs cell derivation and manufacturing PureStem technology, with its many potential advantages, including industrial scalable manufacturing, lower cost of goods, and clonal cells with high purity and identity. Our goal is to have an improved neural stem cell production method ready within a year to move into clinical development," said Professor Thompson.

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"We are absolutely delighted to start this exciting collaboration with Professor Thompson, who has worked tirelessly over her career to develop a neural stem cell product candidate for Huntingtons disease and who has already generated preclinical animal data that may support the initiation of clinical studies," said Dr. Nafees Malik, Chief Operating Officer of AgeX. "Moreover, we are very excited to be entering the field of neurology, which has huge clinical and commercial potential. Neural stem cells may be very useful in other neurological disorders that are common in aging demographics, such as Parkinsons, Alzheimers and stroke."

"This is an example of the kind of collaboration we will be seeking under our newly-unveiled collaboration and licensing strategy, which is to run parallel to our in-house product development," said Dr. Greg Bailey, Chair of AgeX. "We will be collaborating with a world leader in their field on a research project which is close to the clinic."

The collaboration includes an opportunity for AgeX to organize a company to be jointly owned with Professor Thompson and other researchers to pursue clinical development and commercialization of cell therapies derived using licensed inventions arising from the research program, as well as certain patent pending technology for neural stem cell derivation, and certain technical data, including animal data, to support IND submissions.

About AgeX Therapeutics

AgeX Therapeutics, Inc. (NYSE American: AGE) is focused on developing and commercializing innovative therapeutics for human aging. Its PureStem and UniverCyte manufacturing and immunotolerance technologies are designed to work together to generate highly-defined, universal, allogeneic, off-the-shelf pluripotent stem cell-derived young cells of any type for application in a variety of diseases with a high unmet medical need. AgeX has two preclinical cell therapy programs: AGEX-VASC1 (vascular progenitor cells) for tissue ischemia and AGEX-BAT1 (brown fat cells) for Type II diabetes. AgeXs revolutionary longevity platform induced Tissue Regeneration (iTR) aims to unlock cellular immortality and regenerative capacity to reverse age-related changes within tissues. AGEX-iTR1547 is an iTR-based formulation in preclinical development. HyStem is AgeXs delivery technology to stably engraft PureStem cell therapies in the body. AgeX is developing its core product pipeline for use in the clinic to extend human healthspan and is seeking opportunities to establish licensing and collaboration agreements around its broad IP estate and proprietary technology platforms.

For more information, please visit http://www.agexinc.com or connect with the company on Twitter, LinkedIn, Facebook, and YouTube.

Forward-Looking Statements

Certain statements contained in this release are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not historical fact including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates" should also be considered forward-looking statements. Forward-looking statements involve risks and uncertainties. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the business of AgeX Therapeutics, Inc. and its subsidiaries particularly those mentioned in the cautionary statements found in more detail in the "Risk Factors" section of AgeXs Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commissions (copies of which may be obtained at http://www.sec.gov). Further, in the case of AgeXs new neural stem cell program there can be no assurance that: (i) any new cell derivation methods will be invented in the sponsored research program, (ii) any derivation methods that may be developed will be sufficient to derive neural stem cells in quantities and of purity suitable for clinical use and commercialization, (iii) that any new inventions or existing technology will be licensed on commercially favorable terms, (iv) that any neural stem cells derived for therapeutic use will be shown to be safe and effective in clinical trials, and (v) that any neural stem cells derived for therapeutic use will be successfully commercialized even if clinical trials are successful. Subsequent events and developments may cause these forward-looking statements to change. AgeX specifically disclaims any obligation or intention to update or revise these forward-looking statements as a result of changed events or circumstances that occur after the date of this release, except as required by applicable law.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200203005261/en/

Contacts

Media Contact for AgeX: Bill Douglass Gotham Communications, LLC bill@gothamcomm.com (646) 504-0890

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AgeX Therapeutics to Collaborate with University of California, Irvine on Neural Stem Cell Research Program for Huntingtons Disease and Other...

Valve is looking to hire a psychologist to help shape gameplay – VG247

Valve is on the lookout for economists, statisticians, and a psychologist to help shape gameplay.

The games company is currently advertising for a number of academic positions, in particular a research psychologist with experience in experimental psychology. According to the job listing, Valve hopes to know more about human behavior and about the motivations and influences underlying how and why people do what they do.

We believe that all game designers are, in a sense, experimental psychologists. That is why were looking for an experimental psychologist with superior research skills to apply knowledge and methodologies from psychology to game design and all aspects of Valves operations. We want to leverage your experience with experimental design, research methods, statistics, and human behavior to help craft even more compelling gameplay experiences for future Valve titles. Wed also expect you to research and weigh in on any and all topics that are relevant to improving the experiences of our customers, partners, and employees.

The role requires someone with a graduate degree in psychology and a minimum of four years experience in experimental design and research methods to provide relevant insight into human behavior in order to shape gameplay and customer experience. The listing also mentions researching new hardware technology.

During GDC last year, Valves Principal Experimental Psychologist Mike Ambinder spoke about speculative technologies like brain-computer interfaces in his session Brain-Computer Interfaces: One Possible Future for How We Play.

[W]hile current interaction patterns are restricted to interpretations of mouse, keyboard, gamepad, and gestural controls, future generations of interfaces may include the ability to interpret neurological signals in ways that promise quicker and more sensitive actions, much wider arrays of possible inputs, real-time adaptation of game state to a players internal state, and qualitatively different kinds of gameplay experiences, reads the talks description.

Valve is also on the lookout for a statistician to mine through data and create statistical models to explain past behavior and to predict future behavior across all Valve products. Similarly, the role for an economist seeks someone to develop economic models to identify what leads to fun and rewards experiences in games and on Steam.

Valve is hiring for a total of 14 positions, including a software engineer with esports experience and two writing positions. You can check those out on the official Valve Software website.

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Valve is looking to hire a psychologist to help shape gameplay - VG247

Where are you most likely to be in a crash in the Triangle? – WRAL.com

By Cullen Browder, WRAL anchor/reporter, & Randall Kerr, WRAL Investigates producer

Raleigh, N.C. As the Triangle continues to grow, so does the number of crashes on area roads. But crashes are rising at a disproportionate rate.

Over the past 10 years, Wake Countys population has grown by 26 percent. During that same time, vehicle crashes in the county soared a whopping 45 percent.

WRAL Investigates went through North Carolina Department of Transportations raw data on crashes along state-owned roads and highlighted the areas where defensive driving should be top priority.

The most recent DOT data, reflecting crash numbers from 2014 to 2018, shows dozens interchanges and intersections in Raleigh that experienced at least 100 crashes during that period. High-volume roads like Capital Boulevard, Wake Forest Road and Western Boulevard inside the Interstate 440 Beltline are littered with high-crash-rate spots.

But it was highway interchanges that grabbed the top five spots where the crash frequency was high. No. 1 on the list was the Capital Boulevard interchange with I-440 in north Raleigh, with 484 crashes. The nearby I-440 interchange at Wake Forest Road was a close second, with 470 crashes. Interstate 40 at South Saunders Street in south Raleigh was third, followed by the I-440 interchange with New Bern Avenue in east Raleigh and the I-440 interchange with Glenwood Avenue, near Crabtree Valley Mall.

"All crashes are not created equal," said Jed Niffenegger, Raleigh's traffic engineer.

While the DOT data provides raw numbers on crashes, his unit ranks intersections based on the severity of the crashes, injuries and traffic volume.

"You would expect high-volume intersections to have a lot of crashes," Niffenegger said. "We try to find locations where the crashes are severe."

The intersection at Corporation Parkway and New Hope Road in east Raleigh is tops on the citys most dangerous list, followed by Dawson Street at South Street downtown and Falls of Neuse Road at Common Oaks Drive in north Raleigh.

When those intersections are identified, the city will look at all of the options to make it safer for drivers, Niffenegger said.

"We'll go out, do field investigations, do crash diagrams to look for patterns, look for issues that might be causing it because, a lot of times, its human behavior," he said.

Raleigh crash mitigation efforts include more visible stop lights, restricting turn lanes and, when it comes to areas with a high number of T-bone crashes, red light cameras have a huge impact.

When it comes to simple crash frequency, however, the intersection of Blue Ridge Road and Glenwood Avenue at Crabtree Valley Mall had more crashes than every other non-interstate interchange 330 between 2014 and 2018.

Drivers said theyre not surprised. Prentice Herring said she experienced a close call there a couple of weeks ago.

"I turned right there at that intersection, and there was a dangerous move by a driver that could have been an accident," Herring said. "[He] cut across traffic without any warning.

The most crash-prone intersection in Durham was I-40 at Fayetteville Road, followed by I-40 at N.C. Highway 55 and Interstate 85 and Guess Road.

In Fayetteville, U.S. Highway 401 at Morganton Road grabbed the top spot, followed by the intersection of Skibo and Raeford roads and South Reilly and Cliffdale roads.

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Where are you most likely to be in a crash in the Triangle? - WRAL.com

Union County Means Business Networking Breakfast to Showcase Renowned Leadership Coach Tony Chatman – TAPinto.net

Union County, NJ -- The Union County Board of Chosen Freeholders is pleased to welcome internationally known leadership coach Tony Chatman as keynote speaker for the fourth annual Union County Means Business Networking Breakfast.

The event will be held on Wednesday, February 19 at 8:30 a.m. at the Kean University STEM Building, 1075 Morris Avenue in Union Township and is open to all Union County business owners, managers and entrepreneurs. Breakfast is included and preregistration is required online atucnj.org/ucmb.

Mr. Chatman is well known for his ability to connect people with practical, usable knowledge that helps them achieve their goals in business and in life. His focus on diversity and inclusion is especially relevant to our business community, and his background in science and human behavior provides him with unique insights into relationships between people, said Freeholder Chairman Alexander Mirabella.

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Tony Chatmanhas worked with hundreds of corporations and government agencies including the U.S. Secret Service, Chase Bank, Estee Lauder, NOAA and NASA. As a keynote speaker he is known for his passion, stage presence and intensity.

Tony was only the second African American to receive a bachelors degree from Western Michigan Universitys prestigious Paper Science and Technology School. While working as a chemical engineer for a Fortune 500 company, he had a life changing interaction with an at-risk youth that inspired him to embrace a new career in the non-profit sector. His work in counseling led him to study human behavior with the intent to understand what makes people tick, excel, and change.

Mr. Chatman delivered his first TEDx talk in 2018 and recently completed his first book,The Force Multiplier: How to Lead Teams Where Everyone Wins.

Union County Means Business is an initiative of the Union County Board of Chosen Freeholders, designed to connect the local business community with hands-on guidance and resources for growth. It began as an initiative of Chairman Mirabella in 2012, and has grown since then to include additional programs.

For more information about the Networking Breakfast and other Union County Means Business programs, visitucnj.org/ucmbor contact Deana Mesaros by phone at 908-659-7412 or by email atdmesaros@ucnj.org.

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Union County Means Business Networking Breakfast to Showcase Renowned Leadership Coach Tony Chatman - TAPinto.net

Pair bonding may be the foundation of human and primate societies – ZME Science

New research into primate social structures offers insight into how human social life is organized.

Primates can develop quite complex social structures just look at ours, were primates too. But exactly what made this family of species move towards a group rather than individual lifestyle? Thats what Luca Pozzi from the University of Texas at San Antonio (UTSA) Department of Anthropology, in collaboration with Peter Kappeler at the German Primate Center-Leibniz Institute for Primate Research, set out to understand.

The duo identified pair bonding as a key transition system between solitary and community lifestyles.

The evolution of complex social systems in mammals, and more specifically in primates, is a challenging and exciting area of research. Our study shows that pair livingalthough raremight have played a critical role in it, says Pozzi.

Living as a pair represents an evolutionary puzzle in the evolution of mammalian social systems because males could achieve higher rates of reproduction if they did not bond to a single female.

Pozzi explains that social systems can work as an adaptive tool. Species need to adapt to their environmental conditions, he says, which is the same process that drives biological evolution. However, a modification of social behavior can accomplish the same goal at a much faster pace than natural selection. Among half of all primate species live in groups, he adds, while a third only form pairs; the rest (roughly one third) enjoy solitary lifestyles.

In order to understand what drives this behavioral adaptation process, which factors shape it, and how many times it occurred in the past, the team analyzed genetic data and behavioral observations of 362 primate species. The team found that the transition from a solitary way of life towards living in groups most often occurred through pair bonding. Thus, the propensity to form long-term pairs can be seen as the first step towards complex social structures, they explain.

There are two current hypotheses on the development of pair bonding, the team explains: the female spacing hypothesis and the paternal care hypothesis. The first hypothesis holds that females pursue reproductive strategies that are not limited by the number of mates but by access to resources, and that under certain conditions (such as high competition for food) females may spread out, limiting males ability to monopolize access to multiple females. The second one basically boils down to the idea that males may choose to focus on a single female because she either needs his help in raising the offspring (for protection, care, or provision) or to reduce the risk of strange males committing infanticide. Either way, the male in question enjoys greater net reproductive success even if he limits his mating opportunities. Evidence is mixed for both hypotheses, the team adds.

Up to now, the assumption was that these two hypotheses were mutually exclusive. But the team found that they were actually complimentary.

An initial ecological change led the females of a species to separate in space. Solitary males, which previously had several females living in their territory, were now only able to gain access to one female and started to invest more in their offspring to increase their chances of survival thus reinforcing pair living. A further transition to group living was made possible through an improvement of the ecological situation, which allowed related females to live in close proximity once again, and they could then be joined by one or more males.

However, the pair bond typical for humans within larger social units cannot be explained with our results, since none of our recent ancestors lived solitarily. Nevertheless, the advantages of paternal care also may have led to a consolidation of pair living in humans, said Kappeler.

The paper Evolutionary transitions towards pair living in non-human primates as stepping stones towards more complex societies, has been published in the journal Science Advances.

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Pair bonding may be the foundation of human and primate societies - ZME Science

Industry insiders share their Super Bowl ad picks – Campaign US

Jeep? Google? Facebook? Many spots aired during last nights Super Bowl, but they werent all winners.

Campaign US asked a variety of industry executives to give their hot takes on the best commercials of the big game. See their answers below.

Mountain Dews "As Good as the Original." Classic Super Bowl theatre with suspense, plot twist and iconic characters. Strong idea that pays off product proposition. And it has just the right level of insanity to make it stand out on the big stage

Hyundai Sonata - Being from Boston I loved the use of our famous accent.

Google - Reminded us that AI can make our memories richer and more accurate

Facebook - Started ADCOLOR as a Facebook group. I found my tribe of fellow diversity champions.

Rocket Mortgage - Made me laugh out loud. Really hit the message of finding your home in every sense of the word.

Jeeps "Groundhog Day"

I thought it was a terrific use of culture on many levels and yet it was a product demonstration. The production value was great, every joke landed. Everyone has gotten this brief to do something for Groundhog Day and they did it brilliantly

If I have to pick one spot that felt big, contextual, strategic, creative and had "game day" entertainment value it would have to be Jeeps Groundhog Day.

It checked all of the boxes a SB spot should check.

It didnt take itself too seriously nor did it try and save the world.

It wasnt trying to mask itself as a sequel, or something that was bigger than it is, it simply played right into our love for nostalgia and all things Bill Murray.

It didnt overpromise and under deliver, nor did it try and co-opt any sort of culture that Jeep had no business co-opting.That is why I give it my nod as the best spot from this years Super Bowl.

McDonalds Famous Orders ad was one of my favorites out of the gate. It was smart, insightful and edited flawlessly. The best creative has a universal human truth; Famous Orders is based on a global human truth that no matter if you love or love to hate McDonalds, you have a favorite order."

Cheetos was a fun play on a product truth that everyone can relate to.

The Alexa spot What do you think people did before Alexa? was so smart, and it fits well with Ellen DeGeneres humor and curious comedic reflection. The idea makes Alexa more human.

Google was my favorite. Id explain why but I have to stop crying first.

All four of these spots have one thing in common: they all are clever creative solutions that put their products right in the middle of the story. The story and the product are intertwined. Well done!

It's challenging to create a multi-scene spot while keeping it simple, lovable and memorable. 'Groundhog Day' did just that. And it used the actual characters from the movie to commemorate not the Super Bowl, but Groundhog Day 2020. There's a planner somewhere who earned their Jeep Gladiator bonus - complete with groundhog option.

We saw celebrities leading brands, instead of brands leading the charge. Sure, weve seen a few really good ideasNew York life, for example; but a lot of the big brands have been an assessment of who they signed. That can work when there is great alignment between the brand and the person, but too often it seems like we are letting celebs outshine ideas. Tomorrow people will talk about that Brady ad instead of that Hulu spot.

The positive is that this is advertisings biggest stagedespite the ad avoiding, subscribing, distracted audience we covet. And tonight we have everyones attention. As an industry, its awesome that we can all celebrate the stage and that the conversation is bigger than just the ads. Diversity, empathy and change are front-and-center in our industry and in the advertising conversation, and thats a good thing.

The real issue behind killing off Mr. Peanut is that the creatives who hoped to produce a buzz-worthy moment forgot that the concept of death, can actually be quite unfunny. The death of NBA star Kobe Bryant left us all feeling a momentary glimpse of the excruciating pain of losing someone in an untimely way - and how simple things like a trip to the grocery store, folding the laundry or even a silly TV commercial can disrupt and interrupt the healing process. Always test your jokes out on the people you are most worried about offending before moving ahead with them.

The Olay ad felt like it was written by a man. I love a female empowerment theme as much as the next woman, but this felt forced for face cream. It is like someone in the room yelled, "female lead characters tend to score higher" and someone jotted up a random list of favorites onto a spare napkin. I didnt connect to the brand or product and it felt disjointed. Bigger props to a brand that launched a spot that feels more strategically sound; SodaStream returns to the Super Bowl with an entertaining space quest that puts their fresh water front and center while shining a spotlight on environmental issues. A trip to space I WILL remember.

Groundhog Day is an obvious pick, but I also loved the unexpected simplicity of the "Hulu has Live Sports" ad with Tom Brady. Earlier in the week, Brady released a cryptic image on Instagram of himself in a dark stadium tunnel. Many speculated that it was a prelude to him announcing that he was leaving the Patriots or retiring. It fueled fan debate but also served as the perfect set up. If youre a big football fan, it got your attention immediately. More so than most of the ads, it was relevant to the game and one of the most memorable. Most ads try to do too much. Hulu kept it simple and used the sports biggest star in a super creative and effective way.

Favorite ad: "Groundhog Day" by Jeep.

Every creative has presented 50 ideas starring Bill Murray -- he must have been drawn by storyboard artists five million times and lives in 50,000 keynote decks. No one can ever get him. But they did. Hats off!

Favorite ad: Quicken Loans Rocket Mortgage: "Comfortable." The Super Bowl is a place where muscle-y people enjoy talking to you about what it takes to be strong and confident, so watching a ridiculously beautiful Jason Momoa walk into his rich person home with a self-satisfied smile on his handsome face perfectly lolls you into a sense of security, before systematically removing it from you in the course of the 60-second ad, leaving you with the weird kind of uncomfortable feeling that only the best ads give you. If you watched the ad with your eyes closed, you wouldnt have known there was a joke at all. Jason Momoa doesnt say anything funny at all. This self-discipline and focus on a single-joke is almost impossible to achieve, especially in the context of a Super Bowl ad where everybody wants the comedy to come at you from all angles.

Heartfelt and Human: The brands that stood out this year were tuned into the psyche of humankind. The past 12 months have been a deluge of concerning news spanning politics, health and human behavior. This wears on us all, and sometimes we need a pick me up and a positive reminder of what life could be like. These brands nailed that.

Budweisers "Typical American" spot is so damn good. Its an ad focused on what each of us can bring to society and achieve when our best selves are presented, whether it is in our job, a competition, a reunion, standing up for what we believe in or helping a stranger.

Kias ad with NFL rookie Josh Jacobs talking to his younger self is a beautiful reflection of what we can overcome and accomplish in our lives if we give it everything.

Googles spot has us all wanting to know Loretta. She seemed to have a beautiful life and partner and the spot serves as a reminder of what truly matters. Also, it highlights that perhaps technology can help improve our lives as well, if and when we use it in a purposeful and meaningful way.

All the celebrity laden ads started to blend together, so when the Google Loretta film appeared, it really stood out. It also never hurts to have :90 to tell a story.

I felt that too many brands leaned too far into celebrity and not enough into human and emotional connections. With that said, I felt that Loretta, Googles Super Bowl Commercial, took us on an emotional journey sharing a story that connected a human experience through product and technology.

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Industry insiders share their Super Bowl ad picks - Campaign US

Predictive Analytics Software Market What Opportunity Industry is Leveraging – GuruFocus.com

Advance Market Analytics released the research report of Global Predictive Analytics Software Market, offers a detailed overview of the factors influencing the global business scope. Global Predictive Analytics Software Market research report shows the latest market insights with upcoming trends and breakdown of the products and services. The report provides key statistics on the market status, size, share, growth factors of the Global Predictive Analytics Software.

This Report covers the emerging players data, including: competitive situation, sales, revenue and global market share of top manufacturers are Anodot [Israel], Sisense [United States], The MathWorks [United States], MicroStrategy [united States], Alteryx [United States], Radius [United States], Maroon.ai [United States], SAS Institute [United States], GMDH [United States] and Alpha7 [Singapore].Definition: Predictive analytics software utilities big data, machine learning and statistical algorithm in tandem to predict the future scope based on historical data and statistics. The software offers unique platform for enterprises to identify future trends and act accordingly. This data mining software helps to determine customer purchasing behavior thus, an opportunity to help retain their profitable customers.

Free Sample Report + All Related Graphs and Charts @ : https://www.advancemarketanalytics.com/sample-report/11119-global-predictive-analytics-software-market

Market Drivers

Growing Adoption of Predictive Analytics in Order to Forecast Future Market Trends

Rising Big Data and Related Technologies

Market Trend

Integration of Services with Cloud

Growing Use of Texts in Predictive Models

Restraints

Issue Related with Accuracy of Data

Varying Data Protection Rule in Different Countrie

Opportunities

Emergence of Machine Learning and AI

Advancement in Analytics Tools Leads to Rise in Adoption

Challenges

Security and Privacy Related Concern

Inability to Understand Human Behavior

The Global Predictive Analytics Software Market segments and Market Data Break Down are illuminated below:Application (Small and Medium Enterprises (SMEs), Large Enterprises), Industry Vertical (Retail and eCommerce, Manufacturing, Government and Defense, Healthcare and Life Sciences, Energy and Utilities, Telecommunication and IT, Transportation and Logistics, BFSI, Others (Media and Entertainment, Travel and Hospitality, and Education)), Deployment Model (On-premises, Cloud)Region Included are: North America, Europe, Asia Pacific, Oceania, South America, Middle East and Africa

Country Level Break-Up: United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/11119-global-predictive-analytics-software-market

Strategic Points Covered in Table of Content of Global Predictive Analytics Software Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the Global Predictive Analytics Software market

Chapter 2: Exclusive Summary the basic information of the Global Predictive Analytics Software Market.

Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges of the Global Predictive Analytics Software

Chapter 4: Presenting the Global Predictive Analytics Software Market Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.

Chapter 5: Displaying the by Type, End User and Region 2013-2018

Chapter 6: Evaluating the leading manufacturers of the Global Predictive Analytics Software market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix and Company Profile

Chapter 7: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions.

Chapter 8 and 9: Displaying the Appendix, Methodology and Data SourceFinally, Global Predictive Analytics Software Market is a valuable source of guidance for individuals and companies.Data Sources and MethodologyThe primary sources involves the industry experts from the Global Predictive Analytics Software Market including the management organizations, processing organizations, analytics service providers of the industrys value chain. All primary sources were interviewed to gather and authenticate qualitative and quantitative information and determine the future prospects. In the extensive primary research process undertaken for this study, the primary sources Postal Surveys, telephone, Online and Face-to-Face Survey were considered to obtain and verify both qualitative and quantitative aspects of this research study. When it comes to secondary sources Companys Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were given primary weight-age.Get More Information: https://www.advancemarketanalytics.com/reports/11119-global-predictive-analytics-software-market What benefits does AMA research studies provides?

Supporting company financial and cash flow planning

Open up New Markets

To Seize powerful market opportunities

Key decision in planning and to further expand market share

Identify Key Business Segments, Market proposition and Gap Analysis

Assisting in allocating marketing investments

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.About Author:

Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.

Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends and dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources, our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enable clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to MandAs. Contact Us:

Craig Francis (PR and Marketing Manager) AMA Research and Media LLPUnit No. 429, Parsonage Road Edison, NJ New Jersey USA 08837 Phone: +1 (206) 317 1218 [emailprotected] Connect with us athttps://www.linkedin.com/company/advance-market-analyticshttps://www.facebook.com/AMA-Research-Media-LLP-344722399585916https://twitter.com/amareport

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Predictive Analytics Software Market What Opportunity Industry is Leveraging - GuruFocus.com

Four Pillars Of Smart Investing: Game-Changing Tools That Prevent Stupid Mistakes – Seeking Alpha

Stupid is as stupid does. Forrest Gump

Everyone is stupid. Only on different subjects. Will Rogers

The critical step in smart investing is realizing what matters most. By focusing on this most important aspect, smart investors spend their time, energy and money wisely, and avoid distractions that take their eyes off the prize of reaching goals. Saving enough is the most important action an investor can take. The second most important action is investing it wisely, but this is a distant second. Save and protect is a smart mantra.

If youve saved enough, it may be best to simply be safe, and protect it. Importantly, there comes a time in most lives when whatever youve saved must be enough because its all youll ever have. For those who dont have a defined benefit pension, that time is when you leave the workforce and begin retirement.

Saving enough is not an investment decision, its a behavioral goal. In the following we provide guidance on wisely investing whatever you have saved, with the perspective that it will have to be enough by necessity when you enter retirement.

Asset allocation is the most important investment decision. It explains 100% of investment performance - yes, all of it. Getting asset allocation right is the smartest investment thing you can do. Its much more important than security selection. Stock picking might be more fun, but picking the very best securities doesnt matter nearly as much as your asset allocation. We discuss smart asset allocation in this article.

The following periodic chart demonstrates the importance of asset allocation. In 2018 everything lost and in 2019 everything won. The average spread between the best and worst performing asset classes is 32% each year. Importantly for investor memory and behavior, everything except commodities won over the past decade.

Focusing on the past decade in the next graph, asset allocation has been important, and it will likely be even more important in the next decade. Portfolios with high allocations to US stocks and real estate performed far better in the past decade than those that held commodities. Since most US investors hold US stocks and real estate, they can view themselves as smart in the past decade, but the next decade is going to be much more challenging for reasons we discuss in this article. For some, the recent good times are all they have experienced, but it will not go on forever.

Fortunately there are tools for intelligent investing that develop smart asset allocation. The best tools are easy to use and, most importantly, manage risk in the Risk Zone that spans the five years before and after retirement when savings are at their peak, making losses most damaging. Investors can use these tools in their 401(K)s, their Individual Retirement Accounts (IRAs), and their personal accounts.

There are 78 million Baby Boomers in the Risk Zone who would be dumb to not use these game-changing tools. Most Boomers are making a stupid mistake by not protecting themselves in the Risk Zone. They are on average 60% in equities and 40% in long term bonds, an allocation that lost 30% in 2008.

As discussed in the next section, smart asset allocation is challenging, but can be accomplished with the right tools.

Asset allocation is the first pillar of smart investing. Its designed to achieve objectives with an acceptable likelihood. Allocations are adjusted in response to successes and failures in this achievement. Plus goals change through time. This financial navigation is dynamic and challenging.

Asset allocation decisions are risk decisions. You need to take a certain amount of investment risk in order to earn the return you need to achieve your objectives. Dr. Frank Sortino, father of Post-modern Portfolio Theory, calls this target return the Minimal Acceptable Return. This risk decision is called risk preference or risk necessity. It should not be confused with market timing, another separate motivation for modifying risk. The risk preference pillar needs to be conditioned on three more pillars:

There are circumstances when you simply should not take the risk it requires to achieve your objectives because you dont have the risk capacity. In particular, theres a time in everyones life when risk capacity is very low because the stakes are as high as they will ever be. You cannot afford to lose your lifetime savings at this critical juncture in your life, warranting its title as the Risk Zone that spans the 5-10 years before and after retirement.

Losses in the Risk Zone can devastate retirement lifestyle and reduce the length of time that savings last, even if markets subsequently recover. Sequence of Return Risk is the source of this Risk of Ruin. Even the wealthy should protect themselves in the Risk Zone because they too have plans that can be ruined, and heirs who could inherit less. The rich can be devastated too. After all, they have a lot to lose. In the U.S. there are 78 million baby boomers in the Risk Zone, most of whom are taking way too much risk.

Smart asset allocation is tailored to achieve your goals, unless you cannot tolerate the required risk, especially in the Risk Zone. If you use an investment advisor, you are most likely invested in a model portfolio, but most models fail to recognize age and the Risk Zone, recklessly striving for an MAR regardless of risk capacity. Fortunately, there are better models. Recognizing your capacity is the second guidepost.

As for the third pillar, the smartest way to take risk when youre young is to be as diversified as possible: Global stocks and bonds, real estate, commodities, etc. Then as you enter the Risk Zone, the smartest way to control risk is with safe assets, like Treasury Bills. Dr. William F. Sharpe won a Nobel Prize for his revolutionary discovery called the Capital Market Line. The smartest way to control risk is not to add more bonds, its to blend a broadly-diversified world basket of risky assets with safe assets. Diversification and smart risk control provide the best returns for the risk taken over time.

And the fourth pillar - being cost conscience - is simply common sense. Costs reduce returns. Interestingly, the desire to diversify and to keep costs low has recently driven investors to passive index investing, especially in Exchange-Traded Funds. Investors are getting it.

The smartest asset allocation integrates risk willingness with risk capacity, primarily age. Ignoring risk capacity is stupid because it exposes investors to catastrophic risk at precisely the wrong time. Retirements are not ruined by investment losses. Theyre ruined by big investment losses at the wrong time, namely during the transition from working life to retirement. This is not market timing, although current economic conditions reinforce the need to defend now in the Risk Zone. We are likely to suffer a major market correction sometime in the next decade, and those in the Risk Zone will be impacted the most.

Beyond the Risk Zone, retirees are best served by re-risking in order to extend the life of investments. This is contrary to the old rule of thumb that advocates 100 minus your age in equities. Groundbreaking research by Dr. Wade Pfau and Michael Kitces has revolutionized optimal investing in retirement.

The good news is that today there's financial engineering designed to not lose money and to provide the highest returns for the risk that is taken. Better investing through science.

We can expect certain things to happen in the next decade. FOMO (Fear Of Missing Out) has been a primary driver of recent stock market gains, but that will eventually morph into FOBO (Fear Of Bad Outcomes). Baby Boomers born between 1946 and 1964 will be passing through the Risk Zone for the next 15 years, during which the odds are not good for dodging a market setback. The only question is how bad the next correction will be.

Weve just completed one of the best decades in history, and are currently enjoying the longest stock market recovery. This has led to sky-high prices, which means the US stock market is extraordinarily expensive. At the same time, the world is facing a debt crisis and socioeconomic pressures are threatening the world, especially with China, Iran and North Korea. Its a scary time.

According to Capital Market Consultants, the US economic outlook at the end of 2019 is precarious:

No one has an accurate crystal ball, but we do have a formula that always works for forecasting returns. Its currently forecasting a 46% loss if P/E ratios fall from their current lofty 30 down to their historical 15 level. The following table shows the ranges of possible returns in 2020. As you can see, P/E is the primary driver of returns - its primary determinant is human behavior. If P/Es remain at their current 30 level, the return in 2020 will be 8%, but that would require prices to remain extraordinarily high.

Exacerbating lofty stock market prices, per capita world debt has surged to over $200,000, due in large part to quantitative easing that has simply put off the inevitable global recession. The US is in even worse shape than you think. The world economy is running on the fumes of delusory borrowed money, playing an outlandish game that will not end well. We owe each other money that wont be paid in todays dollars. Thats why crypto currencies were invented. Fiat money only works if we all agree to honor it. Otherwise its just pieces of paper. US currencies were debased in 1971 when they were taken off of the gold standard and replaced by In God We Trust. Now debasing means printing money, or monetizing the debt. Lenders lose when borrowers control payment values.

The World Debt Crisis manifests itself in a variety of problematic ways, as shown in the following:

In his outlook for 2020 Lawrence Fuller, publisher of the Portfolio Architect, says:

My greatest concern for the year ahead is that the Fed has fueled a surge in financial markets that is now so far divorced from economic fundamentals that an inevitable reversion to the mean will reverse this wealth effect. The subsequent collapse in confidence will come at a time when our debt-laden economy is barely growing. The Fed will have minimal firepower to address the next downturn with monetary stimulus. The federal government will be equally impotent considering it just implemented a massive tax cut and faces $1 trillion deficits.

Similarly, industry expert Lance Roberts, Managing Partner of RIA Pro, warns:

With debt levels rising globally, economic growth on the long end of the cycle, earnings growth weak, valuations high, and potential risk of a recession, the uncertainty of retirement plans has risen markedly. This lends itself to the problem of individuals having to spend a bulk of their "retirement" continuing to work

Yes, not only should you worry about bear markets, you should worry about them a lot.

Individual investors can learn from institutions with their substantial resources and research. According to FS Investments, institutional investors have performed far better than individuals in the past two decades:

Target date funds (TDFs), at $2 trillion and growing, are the biggest deal in institutional investing. Individuals can benefit by following the disciplines incorporated in TDFs. Smart investing begins with an assessment of your financial well being, like taking this self-assessment quiz, with its guidelines on what to do next. From there, you can make your own investment decisions, or it might be best to hire an advisor. Either way, smart investors will use game-changing asset allocation tools that follow TDF glidepaths.

Investors can use free asset allocation models available on several websites, but you get what you pay for: These tools do not use TDF disciplines. There are better models that manage risk in the Risk Zone and follow the patented Safe Landing Glide Path that has been used successfully for more than a decade in the SMART Target Date Fund Index. Its primary objective is to not lose money, especially in the Risk Zone. Heres how SMART performed in the past three tests of its primary objective.

Calendar Year

Fund Year

SMART Return

TDF Industry Return

2008

2010

-4

-24

2011

2010

8

0

2018

2020

-1

-4

Importantly, SMART has won by not losing, earning returns comparable to the industry, but with less risk.

Dont Stop Thinking About Tomorrow by Fleetwood Mac is a song we should all be singing at this precarious time. The tectonic plates of investing are shifting and we need to be prepared. One group in particular is in serious danger, namely baby boomers.

The smartest investors spend their time, energy and money on what matters most, namely asset allocation. Getting this critical decision right is not easy. Attempts to improve performance results beyond policy returns typically fail, undermining achievement of your goals. Stock selection and market timing are unproductive at best and typically counterproductive. You can win the performance game but fail to achieve your goals.

Smart asset allocation integrates risk willingness with risk capacity, and is broadly diversified and low cost. The good news is that there are tools to be smart, and they are easy to use and inexpensive. These tools bring the wisdom and disciplines of target date funds (TDFs) to the masses. 401(K) plans have invested more than $2 trillion in TDFs, and growing. According to a recent study by the Wharton School the adoption of low-cost target-date funds may enhance retirement wealth by as much as 50% over a 30-year horizon.

Stupidity in the next decade could be very costly, especially to Baby Boomers who should not be gambling their lifetime savings. You may want to work with an investment advisor during this critical time in your life, but you should verify his/her competence by using these tools. Unfortunately the 60/40 stock/bond Rule is alive and well, and stupid. Trust but verify.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

Additional disclosure: I help investors who want to do it themselves as well as those who want the help of an advisor. I am creator of the Age Sage Robo (please Google) that provides leading edge LifePath asset allocations for advisors and DIY individual investors. I am also CEO of GlidePath Wealth Management that manages personalized target date portfolios.

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Four Pillars Of Smart Investing: Game-Changing Tools That Prevent Stupid Mistakes - Seeking Alpha

Injured Yellowstone coyote killed after biting cross-country skier; crazy details of earlier attacks – Sports and Weather Right Now

An injured coyote bit a 43-year-old woman cross-country skiing near the Grand Canyon of Yellowstone on Tuesday morning, according to a Yellowstone National Park press release.

Park staff temporarily closed the road in the Canyon Village area where the incident occurred before identifying and killing the coyote, which is being tested for rabies.

Encounters like these are rare, but they can happen, said wildlife biologist Doug Smith in the press release. We suspect this coyote may have been starving due to having porcupine quills in its lower jaw and inside its mouth. Its young age likely led to its poor condition and irregular behavior.

The woman, who is a winter resident of the park, was cross-country skiing on the Grand Loop Road near the South Rim Drive when the coyote came up from behind and bit her on the arm, according to Linda Veress, park spokeswoman. Park dispatch received a call about the incident on Jan. 28 at about 9:50 a.m.

Witnesses took the injured woman to the Canyon Visitor Education Center, where rangers provided initial treatment for puncture wounds and lacerations to her head and arm. Rangers then transported her to Mammoth Hot Springs. From there she continued on to a hospital. The victims name was not released.

Snowcoach drivers in the area had seen a coyote acting aggressively, according to Jeff Henry, a Yellowstone winterkeeper. About 20 people live and work in the Canyon area in the winter, he said.

Yellowstones interior is accessible in winter only via over-the-snow vehicles such as snowmobiles, snowcats or such vans equipped with large tires or tracks.

The incident prompted park officials to remind visitors that wildlife in Yellowstone National Park can be unpredictable. Tourists are urged to be aware of their surroundings and never to feed wildlife. Animals that associate humans with food may become aggressive.

What it did was abnormal behavior for a coyote because humans are not prey to coyotes, Veress said. They normally eat small mammals like rodents and rabbits and a variety of smaller items, but humans are not their prey. Therefore, this is unnatural behavior and a human safety threat, and why it was killed.

Some unusual coyote attacks on humans have occurred in Yellowstone in the past, although the park has no exact number because of inconsistent record keeping.

In January 1990, a 27-year-old Illinois man and park employee was cross-country skiing in Biscuit Basin when a coyote lying along the trail leapt up and bit him on the face. He suffered cuts and puncture wounds on his head, face, neck and hands, but managed to deter the coyotes attack by beating it with one of his skis. Three coyotes were later killed by park officials.

Perhaps the most frightening coyote attack in Yellowstone occurred in November 1960 at Mammoth Hot Springs, when a 1 1/2-year-old baby who had been left in a stroller on a porch in the headquarters compound was attacked by a coyote.

A neighbor saw the assault and swatted at the coyote with a broom. The child received 21 stitches to her face and had bruises on her back and arms, but was otherwise protected by a heavy snowsuit.

For strange coyote incidents in Yellowstone, a German tourist being bitten in October 1992 stands out. The 65-year-old man pulled his car over along Sylvan Pass after the coyote was seen biting at his cars tires, according to a news report of the incident. When the man stepped out of the auto, the coyote jumped in and began eating food on the car seat. The tourist was bitten as he shoved the coyote out of the vehicle.

A study of coyote attacks on humans published in 2009 documented 142 incidents resulting in 159 victims between 1960 and 2006 in the United States and Canada. Most attacks occurred within the western portion of the United States, with 49% of attacks occurring in California and 13% in Arizona, according to the study.

Overall, there were a slightly higher number of coyote attacks on children than adults. In attacks classified as predatory, however, the majority of victims were children. Most of the incidents occurred near the victims residence, with about one-quarter occurring in parks.

Almost half of the victims were engaged in some type of recreational activity, which could make the people look like fleeing prey. That would also explain why the majority of the children victims were attacked while playing in their yard. The next most common type of activity of victims prior to attack was resting or sleeping outside (19%). In 1996, one Yellowstone tourist was reportedly bitten on the foot while napping outdoors with his boots off.

The studys authors pointed to the fact many of the attacks occurred in the daytime, not typically when coyotes would be out hunting, suggesting they had become used to humans and human food sources:

A study of human-coyote conflicts in U.S. national parks also found that aggressive behavior by coyotes was exhibited more often in areas where park visitors were feeding coyotes than in areas where wildlife feeding occurred less frequently.

Earlier this month, two coyote attacks were reported in downtown Chicago, one on a 6-year-old boy. Adaptable and intelligent animals, coyotes have become more common in cities across the United States.

In the wild, coyotes typically eat small mammals like mice and voles. In Yellowstone they are sometimes seen scavenging carcasses killed by larger predators, like wolves and bears. Although mistaken for wolves, coyotes are much smaller, weighing about 25 to 35 pounds and standing only 16 to 20 inches high at the shoulder.

Though coyotes once thrived in Yellowstone, their population declined dramatically with the reintroduction of wolves in the 1990s as a result of attacks by wolves, competition for food and loss of territory, according to park information.

In the wake of the Tuesday assault, park officials are reminding visitors all food, garbage or other smelly items should be packed away when not in use. Visitors are required to stay 25 yards away from all large animals bison, elk, bighorn sheep, deer, moose and coyotes and at least 100 yards away from bears and wolves.

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Injured Yellowstone coyote killed after biting cross-country skier; crazy details of earlier attacks - Sports and Weather Right Now